{"text_format":"1","workbook":"xlsx","n_sheets":4,"sheets":["Overview_VMP","Detail_VMP","Overview_NR","Detail_NR"],"not_rendered":{"charts":0,"images":0,"macros":1,"external_links":0,"defined_names":5,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900"}

{"sheet":"Overview_VMP","index":0,"n_rows":110,"n_cols":25,"rows_kept":110,"cut":false,"hidden":false,"merged":[]}
["VMP Overview",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Type"]
[]
["MeSHName",null,null,null,"Antigens, CD40","Chemokine CCL2","Chemokine CXCL10","Chemokine CXCL9","Collagen Type III","E-Selectin","Macrophage Colony-Stimulating Factor","Matrix Metalloproteinase 1","Matrix Metalloproteinase 9","NF-E2-Related Factor 2","Plasminogen Activator Inhibitor 1","Receptor, Epidermal Growth Factor","Receptors, LDL","Receptors, Thromboxane A2, Prostaglandin H2","Receptors, Urokinase Plasminogen Activator","Serum Amyloid A Protein","Thrombomodulin","Tissue Inhibitor of Metalloproteinase-1","Transforming Growth Factor beta1","Vascular Cell Adhesion Molecule-1","MeSHName"]
["MeSHName","M281","M63","Gene Score",{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & E3,E3)","v":"Antigens, CD40"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & F3,F3)","v":"Chemokine CCL2"},"Chemokine CXCL10","Chemokine CXCL9","Collagen Type III","E-Selectin","Macrophage Colony-Stimulating Factor","Matrix Metalloproteinase 1","Matrix Metalloproteinase 9","NF-E2-Related Factor 2","Plasminogen Activator Inhibitor 1","Receptor, Epidermal Growth Factor","Receptors, LDL","Receptors, Thromboxane A2, Prostaglandin H2","Receptors, Urokinase Plasminogen Activator","Serum Amyloid A Protein","Thrombomodulin","Tissue Inhibitor of Metalloproteinase-1","Transforming Growth Factor beta1","Vascular Cell Adhesion Molecule-1","MeSHName"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y5,Y5)","v":"1,6-hexamethylene diisocyanate"},0,0,1,0,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"1,6-hexamethylene diisocyanate"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y6,Y6)","v":"4-Butyrolactone"},0,0,1,0,1,0,0,1,0,0,0,4,6,0,1,0,0,0,0,0,0,0,0,"4-Butyrolactone"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y7,Y7)","v":"4-vinyl-1-cyclohexene dioxide"},0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,"4-vinyl-1-cyclohexene dioxide"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y8,Y8)","v":"Allethrin"},0,0,1,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,"Allethrin"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y9,Y9)","v":"alpha-cyclodextrin"},0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,2,0,0,0,0,0,0,0,"alpha-cyclodextrin"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y10,Y10)","v":"Busulfan"},0,0,1,2,1,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,1,0,"Busulfan"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y11,Y11)","v":"Caffeine"},0,0,1,0,0,0,0,0,0,0,0,2,2,0,3,2,0,0,0,0,0,2,1,"Caffeine"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y12,Y12)","v":"Caprolactam"},0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,"Caprolactam"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y13,Y13)","v":"Carbamazepine"},0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,"Carbamazepine"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y14,Y14)","v":"celecoxib"},0,0,1,0,5,0,0,1,0,3,1,13,1,1,19,0,0,0,1,1,2,4,6,"celecoxib"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y15,Y15)","v":"Chlorpyrifos"},0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,"Chlorpyrifos"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y16,Y16)","v":"Corticosterone"},0,0,1,0,6,0,0,1,0,0,0,2,0,0,0,5,0,0,4,0,0,1,0,"Corticosterone"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y17,Y17)","v":"Dapsone"},0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,"Dapsone"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y18,Y18)","v":"DDT"},0,0,1,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,"DDT"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y19,Y19)","v":"decamethrin"},0,0,1,0,0,0,0,0,0,1,0,0,6,0,0,0,0,0,0,0,0,0,0,"decamethrin"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y20,Y20)","v":"Diclofenac"},0,0,1,0,2,0,0,1,1,0,1,1,0,0,0,0,2,0,1,0,1,1,1,"Diclofenac"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y21,Y21)","v":"Dimethylnitrosamine"},0,0,1,0,1,0,0,0,0,0,0,0,3,1,0,0,0,0,0,0,6,10,0,"Dimethylnitrosamine"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y22,Y22)","v":"Ethanolamine"},0,0,1,0,0,0,0,0,0,0,0,0,0,0,2,0,0,0,0,0,0,0,0,"Ethanolamine"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y23,Y23)","v":"Ethoxyquin"},0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,"Ethoxyquin"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y24,Y24)","v":"Ethylene Chlorohydrin"},0,0,1,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,1,0,0,"Ethylene Chlorohydrin"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y25,Y25)","v":"Ethylenethiourea"},0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Ethylenethiourea"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y26,Y26)","v":"Fenofibrate"},0,0,1,5,11,1,0,1,2,1,0,7,1,19,1,6,0,0,3,2,3,4,10,"Fenofibrate"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y27,Y27)","v":"Genistein"},0,0,1,0,4,0,0,1,2,2,1,17,7,6,50,2,0,2,0,0,7,9,7,"Genistein"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y28,Y28)","v":"Gentian Violet"},0,0,1,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Gentian Violet"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y29,Y29)","v":"Glycerol"},0,0,1,0,1,0,0,0,1,0,0,1,0,0,1,1,0,0,0,0,0,0,0,"Glycerol"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y30,Y30)","v":"Hydrochlorothiazide"},0,0,1,0,1,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,3,"Hydrochlorothiazide"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y31,Y31)","v":"hydroquinone"},0,0,1,0,3,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,1,"hydroquinone"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y32,Y32)","v":"Isoproterenol"},0,0,1,0,1,0,0,1,0,0,0,5,1,1,8,2,0,0,1,0,2,2,0,"Isoproterenol"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y33,Y33)","v":"limonene"},0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,"limonene"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y34,Y34)","v":"Lindane"},0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,"Lindane"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y35,Y35)","v":"Lovastatin"},0,0,1,4,6,0,0,1,6,2,2,4,0,7,6,65,0,0,1,1,1,3,4,"Lovastatin"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y36,Y36)","v":"Maneb"},0,0,1,0,0,0,0,0,0,0,0,0,2,0,0,0,0,0,0,0,0,0,0,"Maneb"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y37,Y37)","v":"Methotrexate"},0,0,1,0,2,1,0,4,6,2,3,7,1,0,6,1,0,0,3,0,3,1,7,"Methotrexate"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y38,Y38)","v":"Methoxychlor"},0,0,1,0,0,0,0,0,0,1,0,0,0,0,1,0,0,0,0,0,0,0,0,"Methoxychlor"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y39,Y39)","v":"Mifepristone"},0,0,1,0,1,0,0,0,0,0,1,3,2,3,2,0,0,0,0,0,2,3,1,"Mifepristone"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y40,Y40)","v":"naphthalene"},0,0,1,0,0,0,0,0,0,0,0,0,0,0,2,0,0,0,0,0,0,0,0,"naphthalene"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y41,Y41)","v":"Nicotine"},0,0,1,3,9,0,0,1,5,2,4,17,3,4,12,2,0,2,0,0,0,15,13,"Nicotine"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y42,Y42)","v":"Oxytetracycline"},0,0,1,0,0,0,0,0,0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,"Oxytetracycline"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y43,Y43)","v":"perfluorooctane sulfonic acid"},0,0,1,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,"perfluorooctane sulfonic acid"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y44,Y44)","v":"Phenol"},0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,"Phenol"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y45,Y45)","v":"Phenytoin"},0,0,1,0,1,0,0,1,0,0,2,1,0,0,3,0,0,0,0,0,2,1,0,"Phenytoin"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y46,Y46)","v":"Pyrimethamine"},0,0,1,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,"Pyrimethamine"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y47,Y47)","v":"Quercetin"},0,0,1,0,14,2,0,3,3,0,7,16,20,2,15,3,0,1,0,1,6,7,7,"Quercetin"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y48,Y48)","v":"Raloxifene"},0,0,1,1,5,0,0,3,4,2,3,5,0,4,2,0,0,1,0,1,0,4,1,"Raloxifene"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y49,Y49)","v":"Rotenone"},0,0,1,0,0,0,0,0,0,0,0,1,1,0,2,0,0,0,0,0,0,1,0,"Rotenone"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y50,Y50)","v":"Spironolactone"},0,0,1,1,12,0,0,9,0,0,1,3,0,12,2,1,0,0,0,0,4,17,1,"Spironolactone"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y51,Y51)","v":"Tamoxifen"},0,0,1,0,2,0,0,1,0,1,0,9,1,4,96,1,0,2,0,1,4,16,0,"Tamoxifen"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y52,Y52)","v":"Theobromine"},0,0,1,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,"Theobromine"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y53,Y53)","v":"Theophylline"},0,0,1,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,2,2,"Theophylline"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y54,Y54)","v":"Triamcinolone"},0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,"Triamcinolone"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y55,Y55)","v":"acetonitrile"},0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,"acetonitrile"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y56,Y56)","v":"arsenic acid"},0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,"arsenic acid"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y57,Y57)","v":"bis(tri-n-butyltin)oxide"},0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,"bis(tri-n-butyltin)oxide"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y58,Y58)","v":"cyanuric acid"},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,0,"cyanuric acid"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y59,Y59)","v":"Diquat"},0,0,0,0,0,0,0,0,0,0,0,0,3,0,0,0,0,0,0,0,0,0,0,"Diquat"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y60,Y60)","v":"Ethylene Oxide"},0,0,0,0,0,0,0,0,0,0,0,1,0,0,1,0,0,0,0,0,0,0,0,"Ethylene Oxide"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y61,Y61)","v":"Iodine"},0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,1,0,0,0,0,3,1,"Iodine"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y62,Y62)","v":"methyl bromide"},0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,"methyl bromide"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y63,Y63)","v":"nonylphenol"},0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,"nonylphenol"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y64,Y64)","v":"Permethrin"},0,0,0,0,0,0,0,0,0,0,0,0,2,0,0,0,0,0,0,0,0,0,0,"Permethrin"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y65,Y65)","v":"Phenobarbital"},0,0,0,0,0,0,0,0,0,0,0,1,0,0,16,0,0,0,0,0,0,0,0,"Phenobarbital"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y66,Y66)","v":"suplatast tosilate"},0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,"suplatast tosilate"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y67,Y67)","v":"Tannins"},0,0,0,0,1,0,0,0,0,0,0,5,0,0,2,1,0,0,0,0,0,0,0,"Tannins"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y68,Y68)","v":"Triamcinolone Acetonide"},0,0,0,0,3,1,0,0,2,0,1,3,0,1,3,0,0,0,0,0,2,1,2,"Triamcinolone Acetonide"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y69,Y69)","v":"Zalcitabine"},0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Zalcitabine"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y70,Y70)","v":"Acetaminophen"},1,0,1,0,9,1,1,0,0,0,0,1,17,1,0,1,0,0,0,1,0,2,1,"Acetaminophen"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y71,Y71)","v":"Acrylamide"},1,0,1,0,0,0,0,1,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,"Acrylamide"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y72,Y72)","v":"Aspirin"},1,0,1,2,6,0,0,1,7,3,4,16,3,16,5,8,11,1,2,4,4,9,13,"Aspirin"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y73,Y73)","v":"bifenthrin"},1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,"bifenthrin"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y74,Y74)","v":"citral"},1,0,1,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,"citral"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y75,Y75)","v":"cypermethrin"},1,0,1,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,"cypermethrin"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y76,Y76)","v":"Dibutyl Phthalate"},1,0,1,0,0,0,0,0,0,0,0,2,1,1,0,0,0,1,0,0,0,0,0,"Dibutyl Phthalate"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y77,Y77)","v":"Diethylhexyl Phthalate"},1,0,1,0,0,0,0,0,2,0,0,2,0,0,2,0,0,0,0,0,0,6,2,"Diethylhexyl Phthalate"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y78,Y78)","v":"Dimethylformamide"},1,0,1,0,0,0,0,0,0,0,0,0,0,0,5,0,0,1,0,0,0,0,0,"Dimethylformamide"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y79,Y79)","v":"Diphenylamine"},1,0,1,0,0,0,0,0,0,0,0,0,0,0,2,0,0,0,0,0,0,0,0,"Diphenylamine"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y80,Y80)","v":"Endosulfan"},1,0,1,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,"Endosulfan"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y81,Y81)","v":"Estradiol"},1,0,1,12,39,3,0,8,21,10,8,54,6,36,119,23,1,3,1,2,18,41,36,"Estradiol"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y82,Y82)","v":"Ethinyl Estradiol"},1,0,1,0,0,0,0,0,1,1,0,1,0,7,6,24,0,0,1,2,1,1,3,"Ethinyl Estradiol"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y83,Y83)","v":"Glutaral"},1,0,1,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,"Glutaral"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y84,Y84)","v":"Mercuric Chloride"},1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,"Mercuric Chloride"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y85,Y85)","v":"n-butoxyethanol"},1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,"n-butoxyethanol"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y86,Y86)","v":"perfluorooctanoic acid"},1,0,1,0,0,0,0,0,0,0,0,2,3,0,0,0,0,0,0,0,0,0,0,"perfluorooctanoic acid"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y87,Y87)","v":"Sodium Nitrite"},1,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,"Sodium Nitrite"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y88,Y88)","v":"Sulfasalazine"},1,0,1,0,2,0,0,0,3,0,0,1,1,0,0,0,0,0,2,0,0,0,4,"Sulfasalazine"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y89,Y89)","v":"Testosterone Propionate"},1,0,1,0,0,0,0,0,0,0,0,0,1,0,0,1,0,0,0,0,0,0,0,"Testosterone Propionate"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y90,Y90)","v":"Tretinoin"},1,0,1,6,20,2,0,1,6,8,16,35,2,16,86,3,0,5,1,17,16,47,10,"Tretinoin"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y91,Y91)","v":"triadimefon"},1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,"triadimefon"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y92,Y92)","v":"Trichloroacetic Acid"},1,0,1,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,1,0,"Trichloroacetic Acid"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y93,Y93)","v":"vinclozolin"},1,0,1,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,1,0,"vinclozolin"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y94,Y94)","v":"4-octylphenol"},1,1,1,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"4-octylphenol"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y95,Y95)","v":"Atrazine"},1,1,1,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,"Atrazine"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y96,Y96)","v":"bisphenol A"},1,1,1,0,1,0,0,0,0,0,1,2,1,0,3,0,0,0,0,0,0,0,0,"bisphenol A"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y97,Y97)","v":"Chlorpromazine"},1,1,1,0,0,0,0,0,0,0,0,0,0,0,2,0,0,0,1,0,0,0,0,"Chlorpromazine"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y98,Y98)","v":"Diethylstilbestrol"},1,1,1,0,0,0,0,0,0,1,0,1,0,0,7,0,0,0,0,0,0,1,0,"Diethylstilbestrol"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y99,Y99)","v":"Dimethoate"},1,1,1,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,"Dimethoate"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y100,Y100)","v":"Flutamide"},1,1,1,0,1,0,0,0,0,0,0,0,0,0,3,0,2,0,0,0,0,1,0,"Flutamide"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y101,Y101)","v":"Pentachlorophenol"},1,1,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,"Pentachlorophenol"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y102,Y102)","v":"Propylthiouracil"},1,1,1,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,"Propylthiouracil"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y103,Y103)","v":"triadimefon"},1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,"triadimefon"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y104,Y104)","v":"Cacodylic Acid"},1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,"Cacodylic Acid"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y105,Y105)","v":"glyphosate"},1,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"glyphosate"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y106,Y106)","v":"Paraquat"},1,0,0,0,0,1,0,3,0,0,0,3,15,1,0,0,0,0,0,1,3,12,0,"Paraquat"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y107,Y107)","v":"Sodium Fluoride"},1,0,0,0,0,0,0,0,0,1,0,2,0,0,1,0,0,0,1,0,0,1,0,"Sodium Fluoride"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y108,Y108)","v":"Butylated Hydroxyanisole"},1,1,0,0,0,0,0,0,0,0,0,0,7,0,0,0,0,0,0,0,0,0,0,"Butylated Hydroxyanisole"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y109,Y109)","v":"monomethylarsonic acid"},1,1,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,"monomethylarsonic acid"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & Y110,Y110)","v":"Zidovudine"},1,1,0,0,0,0,0,0,0,2,0,0,0,0,0,1,0,0,0,0,0,0,0,"Zidovudine"]

{"sheet":"Detail_VMP","index":1,"n_rows":2223,"n_cols":13,"rows_kept":2223,"cut":false,"hidden":false,"merged":[]}
["Detail VMP",null,"Note: only articles in which the chemical is the main topic are selected."]
["MeSHName","GeneName","M281","M63","Gene Score","Tox","Symbol","PMID","Pub Yr","Title","LinkPMID","MeSHName","GeneName"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L3,L3)","v":"1,6-hexamethylene diisocyanate"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M3,M3)","v":"Chemokine CCL2"},0,0,1,0,"CCL2",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K3,K3)","v":"18498542"},2008,"Human innate immune responses to hexamethylene diisocyanate (HDI) and HDI-albumin conjugates.","18498542","1,6-hexamethylene diisocyanate","Chemokine CCL2"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L4,L4)","v":"1,6-hexamethylene diisocyanate"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M4,M4)","v":"Chemokine CCL2"},0,0,1,0,"CCL2",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K4,K4)","v":"9723671"},1998,"Diisocyanate antigen-enhanced production of monocyte chemoattractant protein-1, IL-8, and tumor necrosis factor-alpha by peripheral mononuclear cells of workers with occupational asthma.","9723671","1,6-hexamethylene diisocyanate","Chemokine CCL2"]
["4-Butyrolactone","Chemokine CCL2",0,0,1,1,"CCL2","14500500",2003,"The Pseudomonas aeruginosa autoinducer N-3-oxododecanoyl homoserine lactone accelerates apoptosis in macrophages and neutrophils.","14500500","4-Butyrolactone","Chemokine CCL2"]
["4-Butyrolactone","Collagen Type III",0,0,1,0,"COL3A1","14967907",2003,"Expression analyses of sex steroid-regulated genes in neonatal rat hypothalamus.","14967907","4-Butyrolactone","Collagen Type III"]
["4-Butyrolactone","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","17786307",2007,"Pharmacological blockade of fatty acid synthase (FASN) reverses acquired autoresistance to trastuzumab (Herceptin by transcriptionally inhibiting 'HER2 super-expression' occurring in high-dose trastuzumab-conditioned SKBR3/Tzb100 breast cancer cells.","17786307","4-Butyrolactone","Receptor, Epidermal Growth Factor"]
["4-Butyrolactone","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","21080941",2010,"Fatty acid synthase phosphorylation: a novel therapeutic target in HER2-overexpressing breast cancer cells.","21080941","4-Butyrolactone","Matrix Metalloproteinase 9"]
["4-Butyrolactone","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","19269818",2009,"Inhibition of NF-kB and metalloproteinase-9 expression and secretion by parthenolide derivatives.","19269818","4-Butyrolactone","Matrix Metalloproteinase 9"]
["4-Butyrolactone","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","15217903",2004,"Inhibition of ICAM-1 gene expression, monocyte adhesion and cancer cell invasion by targeting IKK complex: molecular and functional study of novel alpha-methylene-gamma-butyrolactone derivatives.","15217903","4-Butyrolactone","Matrix Metalloproteinase 9"]
["4-Butyrolactone","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","18457947",2008,"Enterodiol and enterolactone, two major diet-derived polyphenol metabolites have different impact on ERalpha transcriptional activation in human breast cancer cells.","18457947","4-Butyrolactone","Matrix Metalloproteinase 9"]
["4-Butyrolactone","NF-E2-Related Factor 2",0,0,1,0,"NFE2L2","23640758",2013,"Effects of natural phytochemicals in Angelica sinensis (Danggui) on Nrf2-mediated gene expression of phase II drug metabolizing enzymes and anti-inflammation.","23640758","4-Butyrolactone","NF-E2-Related Factor 2"]
["4-Butyrolactone","NF-E2-Related Factor 2",0,0,1,0,"NFE2L2","23688544",2013,"Z-ligustilide activates the Nrf2/HO-1 pathway and protects against cerebral ischemia-reperfusion injury in vivo and in vitro.","23688544","4-Butyrolactone","NF-E2-Related Factor 2"]
["4-Butyrolactone","NF-E2-Related Factor 2",0,0,1,0,"NFE2L2","17391667",2007,"The alpha-methylene-gamma-butyrolactone moiety in dehydrocostus lactone is responsible for cytoprotective heme oxygenase-1 expression through activation of the nuclear factor E2-related factor 2 in HepG2 cells.","17391667","4-Butyrolactone","NF-E2-Related Factor 2"]
["4-Butyrolactone","NF-E2-Related Factor 2",0,0,1,0,"NFE2L2","22146407",2012,"Potential roles of PI3K/Akt and Nrf2-Keap1 pathways in regulating hormesis of Z-ligustilide in PC12 cells against oxygen and glucose deprivation.","22146407","4-Butyrolactone","NF-E2-Related Factor 2"]
["4-Butyrolactone","NF-E2-Related Factor 2",0,0,1,0,"NFE2L2","23441843",2013,"Epigenetic reactivation of Nrf2 in murine prostate cancer TRAMP C1 cells by natural phytochemicals Z-ligustilide and Radix angelica sinensis via promoter CpG demethylation.","23441843","4-Butyrolactone","NF-E2-Related Factor 2"]
["4-Butyrolactone","NF-E2-Related Factor 2",0,0,1,0,"NFE2L2","18567745",2008,"Enterolactone induces heme oxygenase-1 expression through nuclear factor-E2-related factor 2 activation in endothelial cells.","18567745","4-Butyrolactone","NF-E2-Related Factor 2"]
["4-octylphenol","Chemokine CXCL10",1,1,1,0,"CXCL10","19756997",2010,"Suppressive effect on MDC and IP-10 expression in monocytes by endocrine disruptor chemicals.","19756997","4-octylphenol","Chemokine CXCL10"]
["4-vinyl-1-cyclohexene dioxide","NF-E2-Related Factor 2",0,0,1,1,"NFE2L2","16428448",2006,"Accelerated ovarian failure induced by 4-vinyl cyclohexene diepoxide in Nrf2 null mice.","16428448","4-vinyl-1-cyclohexene dioxide","NF-E2-Related Factor 2"]
["Acetaminophen","Chemokine CCL2",1,0,1,1,"CCL2","16081117",2006,"Distinct roles of NF-kappaB p50 in the regulation of acetaminophen-induced inflammatory mediator production and hepatotoxicity.","16081117","Acetaminophen","Chemokine CCL2"]
["Acetaminophen","Chemokine CCL2",1,0,1,1,"CCL2","22334567",2012,"Source and characterization of hepatic macrophages in acetaminophen-induced acute liver failure in humans.","22334567","Acetaminophen","Chemokine CCL2"]
["Acetaminophen","Chemokine CCL2",1,0,1,1,"CCL2","21513726",2011,"Macrophage activation by factors released from acetaminophen-injured hepatocytes: potential role of HMGB1.","21513726","Acetaminophen","Chemokine CCL2"]
["Acetaminophen","Chemokine CCL2",1,0,1,1,"CCL2","15200281",2004,"Correlation of MCP1 with toxicity in acetaminophen overdose.","15200281","Acetaminophen","Chemokine CCL2"]
["Acetaminophen","Chemokine CCL2",1,0,1,1,"CCL2","11981759",2002,"Role of CCR2 in macrophage migration into the liver during acetaminophen-induced hepatotoxicity in the mouse.","11981759","Acetaminophen","Chemokine CCL2"]
["Acetaminophen","Chemokine CCL2",1,0,1,1,"CCL2","20100502",2010,"Potential role of caveolin-1 in acetaminophen-induced hepatotoxicity.","20100502","Acetaminophen","Chemokine CCL2"]
["Acetaminophen","Chemokine CCL2",1,0,1,1,"CCL2","19799668",2009,"Protective effects from carnosine and histidine on acetaminophen-induced liver injury.","19799668","Acetaminophen","Chemokine CCL2"]
["Acetaminophen","Chemokine CCL2",1,0,1,1,"CCL2","16172181",2005,"Cytokines and toxicity in acetaminophen overdose.","16172181","Acetaminophen","Chemokine CCL2"]
["Acetaminophen","Chemokine CCL2",1,0,1,1,"CCL2","10751350",2000,"Exaggerated hepatic injury due to acetaminophen challenge in mice lacking C-C chemokine receptor 2.","10751350","Acetaminophen","Chemokine CCL2"]
["Acetaminophen","Chemokine CXCL10",1,0,1,1,"CXCL10","22868447",2012,"Spred-2 deficiency exacerbates acetaminophen-induced hepatotoxicity in mice.","22868447","Acetaminophen","Chemokine CXCL10"]
["Acetaminophen","Chemokine CXCL9",1,0,1,1,"CXCL9","22868447",2012,"Spred-2 deficiency exacerbates acetaminophen-induced hepatotoxicity in mice.","22868447","Acetaminophen","Chemokine CXCL9"]
["Acetaminophen","Receptors, LDL",1,0,1,1,"LDLR","1289234",1992,"Effect of picroliv on low density lipoprotein receptor binding of rat hepatocytes in hepatic damage induced by paracetamol.","1289234","Acetaminophen","Receptors, LDL"]
["Acetaminophen","Matrix Metalloproteinase 9",1,0,1,1,"MMP9","12392966",2002,"Reduced hepatotoxicity of acetaminophen in mice lacking inducible nitric oxide synthase: potential role of tumor necrosis factor-alpha and interleukin-10.","12392966","Acetaminophen","Matrix Metalloproteinase 9"]
["Acetaminophen","NF-E2-Related Factor 2",1,0,1,1,"NFE2L2","22107450",2012,"Endogenous interleukin-4 regulates glutathione synthesis following acetaminophen-induced liver injury in mice.","22107450","Acetaminophen","NF-E2-Related Factor 2"]
["Acetaminophen","NF-E2-Related Factor 2",1,0,1,1,"NFE2L2","17935745",2008,"Induction of Mrp3 and Mrp4 transporters during acetaminophen hepatotoxicity is dependent on Nrf2.","17935745","Acetaminophen","NF-E2-Related Factor 2"]
["Acetaminophen","NF-E2-Related Factor 2",1,0,1,1,"NFE2L2","16293230",2006,"Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity.","16293230","Acetaminophen","NF-E2-Related Factor 2"]
["Acetaminophen","NF-E2-Related Factor 2",1,0,1,1,"NFE2L2","23863315",2014,"The effect of aging on acetaminophen pharmacokinetics, toxicity and Nrf2 in Fischer 344 rats.","23863315","Acetaminophen","NF-E2-Related Factor 2"]
["Acetaminophen","NF-E2-Related Factor 2",1,0,1,0,"NFE2L2","19246624",2009,"Altered disposition of acetaminophen in Nrf2-null and Keap1-knockdown mice.","19246624","Acetaminophen","NF-E2-Related Factor 2"]
["Acetaminophen","NF-E2-Related Factor 2",1,0,1,1,"NFE2L2","21051083",2010,"Prenatal and infant acetaminophen exposure, antioxidant gene polymorphisms, and childhood asthma.","21051083","Acetaminophen","NF-E2-Related Factor 2"]
["Acetaminophen","NF-E2-Related Factor 2",1,0,1,1,"NFE2L2","24590984",2014,"Fibroblast growth factor 21 protects against acetaminophen-induced hepatotoxicity by potentiating peroxisome proliferator-activated receptor coactivator protein-1?-mediated antioxidant capacity in mice.","24590984","Acetaminophen","NF-E2-Related Factor 2"]
["Acetaminophen","NF-E2-Related Factor 2",1,0,1,0,"NFE2L2","18785192",2008,"The hepatotoxic metabolite of acetaminophen directly activates the Keap1-Nrf2 cell defense system.","18785192","Acetaminophen","NF-E2-Related Factor 2"]
["Acetaminophen","NF-E2-Related Factor 2",1,0,1,0,"NFE2L2","23749887",2013,"Acetaminophen enhances cisplatin- and paclitaxel-mediated cytotoxicity to SKOV3 human ovarian carcinoma.","23749887","Acetaminophen","NF-E2-Related Factor 2"]
["Acetaminophen","NF-E2-Related Factor 2",1,0,1,1,"NFE2L2","11134556",2001,"High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes.","11134556","Acetaminophen","NF-E2-Related Factor 2"]
["Acetaminophen","NF-E2-Related Factor 2",1,0,1,0,"NFE2L2","22491424",2012,"Liver-specific loss of Atg5 causes persistent activation of Nrf2 and protects against acetaminophen-induced liver injury.","22491424","Acetaminophen","NF-E2-Related Factor 2"]
["Acetaminophen","NF-E2-Related Factor 2",1,0,1,1,"NFE2L2","24288682",2013,"5-lipoxygenase deficiency reduces acetaminophen-induced hepatotoxicity and lethality.","24288682","Acetaminophen","NF-E2-Related Factor 2"]
["Acetaminophen","NF-E2-Related Factor 2",1,0,1,0,"NFE2L2","15122755",2004,"Activation of hepatic Nrf2 in vivo by acetaminophen in CD-1 mice.","15122755","Acetaminophen","NF-E2-Related Factor 2"]
["Acetaminophen","NF-E2-Related Factor 2",1,0,1,1,"NFE2L2","23661004",2013,"Protein tyrosine phosphatase 1B modulates GSK3?/Nrf2 and IGFIR signaling pathways in acetaminophen-induced hepatotoxicity.","23661004","Acetaminophen","NF-E2-Related Factor 2"]
["Acetaminophen","NF-E2-Related Factor 2",1,0,1,1,"NFE2L2","21039417",2011,"Nrf2-mediated liver protection by sauchinone, an antioxidant lignan, from acetaminophen toxicity through the PKC?-GSK3? pathway.","21039417","Acetaminophen","NF-E2-Related Factor 2"]
["Acetaminophen","NF-E2-Related Factor 2",1,0,1,0,"NFE2L2","11287661",2001,"An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen.","11287661","Acetaminophen","NF-E2-Related Factor 2"]
["Acetaminophen","NF-E2-Related Factor 2",1,0,1,1,"NFE2L2","23622008",2013,"Effect of paracetamol use on the modification of the development of asthma by reactive oxygen species genes.","23622008","Acetaminophen","NF-E2-Related Factor 2"]
["Acetaminophen","Plasminogen Activator Inhibitor 1",1,0,1,1,"SERPINE1","22319198",2012,"Complement activation in acetaminophen-induced liver injury in mice.","22319198","Acetaminophen","Plasminogen Activator Inhibitor 1"]
["Acetaminophen","Transforming Growth Factor beta1",1,0,1,1,"TGFB1","22334567",2012,"Source and characterization of hepatic macrophages in acetaminophen-induced acute liver failure in humans.","22334567","Acetaminophen","Transforming Growth Factor beta1"]
["Acetaminophen","Transforming Growth Factor beta1",1,0,1,1,"TGFB1","21649732",2012,"Susceptibility of rat non-alcoholic fatty liver to the acute toxic effect of acetaminophen.","21649732","Acetaminophen","Transforming Growth Factor beta1"]
["Acetaminophen","Thrombomodulin",1,0,1,1,"THBD","12654133",2003,"Hyaluronic acid and endothelial damage due to paracetamol-induced hepatotoxicity.","12654133","Acetaminophen","Thrombomodulin"]
["Acetaminophen","Vascular Cell Adhesion Molecule-1",1,0,1,1,"VCAM1","20123118",2010,"Exacerbation of acetaminophen-induced disturbances of liver sinusoidal endothelial cells in the absence of Kupffer cells in mice.","20123118","Acetaminophen","Vascular Cell Adhesion Molecule-1"]
["acetonitrile","NF-E2-Related Factor 2",0,0,0,1,"NFE2L2","23628792",2013,"Differential response to acrylonitrile toxicity in rat primary astrocytes and microglia.","23628792","acetonitrile","NF-E2-Related Factor 2"]
["Acrylamide","Collagen Type III",1,0,1,1,"COL3A1","24622835",2014,"Acrylamide-induced prenatal programming of intestine structure in guinea pig.","24622835","Acrylamide","Collagen Type III"]
["Acrylamide","NF-E2-Related Factor 2",1,0,1,1,"NFE2L2","21540084",2011,"Role of the Nrf2-ARE pathway in acrylamide neurotoxicity.","21540084","Acrylamide","NF-E2-Related Factor 2"]
["Allethrin","Matrix Metalloproteinase 9",0,0,1,1,"MMP9","24055895",2013,"Allethrin toxicity on human corneal epithelial cells involves mitochondrial pathway mediated apoptosis.","24055895","Allethrin","Matrix Metalloproteinase 9"]
["alpha-cyclodextrin","Receptors, LDL",0,0,1,0,"LDLR","18640380",2008,"Dietary alpha-cyclodextrin lowers low-density lipoprotein cholesterol and alters plasma fatty acid profile in low-density lipoprotein receptor knockout mice on a high-fat diet.","18640380","alpha-cyclodextrin","Receptors, LDL"]
["alpha-cyclodextrin","Receptors, LDL",0,0,1,0,"LDLR","2823279",1987,"Prostaglandin E1 suppresses low density lipoprotein receptor activity and cholesterol synthesis in human mononuclear leukocytes.","2823279","alpha-cyclodextrin","Receptors, LDL"]
["arsenic acid","Receptor, Epidermal Growth Factor",0,0,0,0,"EGFR","14674888",2003,"Arsenite and arsenate activate extracellular signal-regulated kinases 1/2 by an epidermal growth factor receptor-mediated pathway in normal human keratinocytes.","14674888","arsenic acid","Receptor, Epidermal Growth Factor"]
["Aspirin","Chemokine CCL2",1,0,1,0,"CCL2","21378140",2011,"Interaction with damaged vessel wall in vivo in humans induces platelets to express CD40L resulting in endothelial activation with no effect of aspirin intake.","21378140","Aspirin","Chemokine CCL2"]
["Aspirin","Chemokine CCL2",1,0,1,0,"CCL2","22217881",2012,"Aspirin inhibits the production of reactive oxygen species by downregulating Nox4 and inducible nitric oxide synthase in human endothelial cells exposed to oxidized low-density lipoprotein.","22217881","Aspirin","Chemokine CCL2"]
["Aspirin","Chemokine CCL2",1,0,1,0,"CCL2","17080224",2006,"No difference in the effects of clopidogrel and aspirin on inflammatory markers in patients with coronary heart disease.","17080224","Aspirin","Chemokine CCL2"]
["Aspirin","Chemokine CCL2",1,0,1,0,"CCL2","15136050",2004,"Aspirin inhibits monocyte chemoattractant protein-1 and interleukin-8 expression in TNF-alpha stimulated human umbilical vein endothelial cells.","15136050","Aspirin","Chemokine CCL2"]
["Aspirin","Chemokine CCL2",1,0,1,0,"CCL2","16600694",2006,"Aspirin and PPAR-alpha activators inhibit monocyte chemoattractant protein-1 expression induced by high glucose concentration in human endothelial cells.","16600694","Aspirin","Chemokine CCL2"]
["Aspirin","Chemokine CCL2",1,0,1,0,"CCL2","17296320",2007,"Platelet monocyte aggregates and monocyte chemoattractant protein-1 are not inhibited by aspirin in critical limb ischaemia.","17296320","Aspirin","Chemokine CCL2"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L68,L68)","v":"Aspirin"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M68,M68)","v":"Antigens, CD40"},1,0,1,0,"CD40",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K68,K68)","v":"21645153"},2011,"Two novel aspirin analogues show selective cytotoxicity in primary chronic lymphocytic leukaemia cells that is associated with dual inhibition of Rel A and COX-2.","21645153","Aspirin","Antigens, CD40"]
["Aspirin","Antigens, CD40",1,0,1,0,"CD40","15140583",2004,"Lack of uniform platelet activation in patients after ischemic stroke and choice of antiplatelet therapy.","15140583","Aspirin","Antigens, CD40"]
["Aspirin","Collagen Type III",1,0,1,0,"COL3A1","14597584",2003,"Anticoagulants (thrombin inhibitors) and aspirin synergize with P2Y12 receptor antagonism in thrombosis.","14597584","Aspirin","Collagen Type III"]
["Aspirin","Macrophage Colony-Stimulating Factor",1,0,1,0,"CSF1","10458713",1999,"Increased proinflammatory cytokines in patients with chronic stable angina and their reduction by aspirin.","10458713","Aspirin","Macrophage Colony-Stimulating Factor"]
["Aspirin","Macrophage Colony-Stimulating Factor",1,0,1,0,"CSF1","15020512",2004,"Reduction of daily life ischaemia by aspirin in patients with angina: underlying link between thromboxane A2 and macrophage colony stimulating factor.","15020512","Aspirin","Macrophage Colony-Stimulating Factor"]
["Aspirin","Macrophage Colony-Stimulating Factor",1,0,1,0,"CSF1","15894964",2005,"Cigarette smoking is associated with increased circulating proinflammatory and procoagulant markers in patients with chronic coronary artery disease: effects of aspirin treatment.","15894964","Aspirin","Macrophage Colony-Stimulating Factor"]
["Aspirin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","22159558",2012,"SNX3-dependent regulation of epidermal growth factor receptor (EGFR) trafficking and degradation by aspirin in epidermoid carcinoma (A-431) cells.","22159558","Aspirin","Receptor, Epidermal Growth Factor"]
["Aspirin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","18196976",2008,"NCX-4016, a nitro-derivative of aspirin, inhibits EGFR and STAT3 signaling and modulates Bcl-2 proteins in cisplatin-resistant human ovarian cancer cells and xenografts.","18196976","Aspirin","Receptor, Epidermal Growth Factor"]
["Aspirin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","16865277",2006,"Acetylsalicylic acid enhances antiproliferative effects of the EGFR inhibitor gefitinib in the absence of activating mutations in gastric cancer.","16865277","Aspirin","Receptor, Epidermal Growth Factor"]
["Aspirin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","24575839",2014,"Phospho-aspirin (MDC-22) inhibits breast cancer in preclinical animal models: an effect mediated by EGFR inhibition, p53 acetylation and oxidative stress.","24575839","Aspirin","Receptor, Epidermal Growth Factor"]
["Aspirin","Receptor, Epidermal Growth Factor",1,0,1,1,"EGFR","8658032",1996,"Gastric adaptation to aspirin and stress enhances gastric mucosal resistance against the damage by strong irritants.","8658032","Aspirin","Receptor, Epidermal Growth Factor"]
["Aspirin","Receptors, LDL",1,0,1,0,"LDLR","3036591",1987,"Aspirin induces alterations in low-density lipoprotein and decreases its catabolism by cultured human fibroblasts.","3036591","Aspirin","Receptors, LDL"]
["Aspirin","Receptors, LDL",1,0,1,0,"LDLR","15485683",2004,"Aspirin inhibits ox-LDL-mediated LOX-1 expression and metalloproteinase-1 in human coronary endothelial cells.","15485683","Aspirin","Receptors, LDL"]
["Aspirin","Receptors, LDL",1,0,1,0,"LDLR","11226331",2001,"Effects of nitric oxide-releasing aspirin versus aspirin on restenosis in hypercholesterolemic mice.","11226331","Aspirin","Receptors, LDL"]
["Aspirin","Receptors, LDL",1,0,1,0,"LDLR","15485676",2004,"Direct vasoprotection by aspirin: a significant bonus to antiplatelet activity?","15485676","Aspirin","Receptors, LDL"]
["Aspirin","Receptors, LDL",1,0,1,0,"LDLR","12209007",2002,"Chronic treatment with nitric oxide-releasing aspirin reduces plasma low-density lipoprotein oxidation and oxidative stress, arterial oxidation-specific epitopes, and atherogenesis in hypercholesterolemic mice.","12209007","Aspirin","Receptors, LDL"]
["Aspirin","Receptors, LDL",1,0,1,0,"LDLR","12208806",2002,"Effect of low-dose aspirin on vascular inflammation, plaque stability, and atherogenesis in low-density lipoprotein receptor-deficient mice.","12208806","Aspirin","Receptors, LDL"]
["Aspirin","Receptors, LDL",1,0,1,0,"LDLR","16326168",2006,"Stabilization of advanced atherosclerosis in low-density lipoprotein receptor-deficient mice by aspirin.","16326168","Aspirin","Receptors, LDL"]
["Aspirin","Receptors, LDL",1,0,1,0,"LDLR","20530721",2010,"Aspirin resistance with genetic dyslipidemia: contribution of vascular thromboxane generation.","20530721","Aspirin","Receptors, LDL"]
["Aspirin","Matrix Metalloproteinase 1",1,0,1,0,"MMP1","15485683",2004,"Aspirin inhibits ox-LDL-mediated LOX-1 expression and metalloproteinase-1 in human coronary endothelial cells.","15485683","Aspirin","Matrix Metalloproteinase 1"]
["Aspirin","Matrix Metalloproteinase 1",1,0,1,0,"MMP1","23126516",2013,"Topical application of a film-forming emulgel dressing that controls the release of stratifin and acetylsalicylic acid and improves/prevents hypertrophic scarring.","23126516","Aspirin","Matrix Metalloproteinase 1"]
["Aspirin","Matrix Metalloproteinase 1",1,0,1,0,"MMP1","15485676",2004,"Direct vasoprotection by aspirin: a significant bonus to antiplatelet activity?","15485676","Aspirin","Matrix Metalloproteinase 1"]
["Aspirin","Matrix Metalloproteinase 1",1,0,1,0,"MMP1","20546553",2010,"Improvement of hypertrophic scarring by using topical anti-fibrogenic/anti-inflammatory factors in a rabbit ear model.","20546553","Aspirin","Matrix Metalloproteinase 1"]
["Aspirin","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","19950575",2009,"[Effects of probucol, aspirin and atorvastatin combination therapy upon atherosclerosis].","19950575","Aspirin","Matrix Metalloproteinase 9"]
["Aspirin","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","24265116",2014,"Acetylsalicylic acid inhibits IL-18-induced cardiac fibroblast migration through the induction of RECK.","24265116","Aspirin","Matrix Metalloproteinase 9"]
["Aspirin","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","11981761",2002,"Aspirin and NS-398 inhibit hepatocyte growth factor-induced invasiveness of human hepatoma cells.","11981761","Aspirin","Matrix Metalloproteinase 9"]
["Aspirin","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","19462226",2009,"Aspirin inhibits MMP-2 and MMP-9 expression and activity through PPARalpha/gamma and TIMP-1-mediated mechanisms in cultured mouse celiac macrophages.","19462226","Aspirin","Matrix Metalloproteinase 9"]
["Aspirin","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","19880272",2010,"Aspirin inhibits MMP-9 mRNA expression and release via the PPARalpha/gamma and COX-2/mPGES-1-mediated pathways in macrophages derived from THP-1 cells.","19880272","Aspirin","Matrix Metalloproteinase 9"]
["Aspirin","Matrix Metalloproteinase 9",1,0,1,1,"MMP9","21962096",2011,"Variations in expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in nasal mucosa of aspirin-sensitive versus aspirin-tolerant patients with nasal polyposis.","21962096","Aspirin","Matrix Metalloproteinase 9"]
["Aspirin","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","24606818",2014,"Enhancement of matrix metalloproteinase 2 and 9 inhibitory action of minocycline by aspirin: an approach to attenuate outcome of acute myocardial infarction in diabetes.","24606818","Aspirin","Matrix Metalloproteinase 9"]
["Aspirin","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","16023759",2006,"Monocyte matrix and ADAM metalloproteinase expression in type 2 diabetes after aspirin therapy.","16023759","Aspirin","Matrix Metalloproteinase 9"]
["Aspirin","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","10811139",2000,"Aspirin inhibits tumor cell invasiveness induced by Epstein-Barr virus latent membrane protein 1 through suppression of matrix metalloproteinase-9 expression.","10811139","Aspirin","Matrix Metalloproteinase 9"]
["Aspirin","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","22045867",2012,"Potentiation of aspirin-induced cerebroprotection by minocycline: a therapeutic approach to attenuate exacerbation of transient focal cerebral ischaemia.","22045867","Aspirin","Matrix Metalloproteinase 9"]
["Aspirin","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","18971601",2009,"Aspirin inhibits MMP-2 and MMP-9 expressions and activities through upregulation of PPARalpha/gamma and TIMP gene expressions in ox-LDL-stimulated macrophages derived from human monocytes.","18971601","Aspirin","Matrix Metalloproteinase 9"]
["Aspirin","Matrix Metalloproteinase 9",1,0,1,1,"MMP9","23809370",2013,"NSAID, aspirin delays gastric ulcer healing with reduced accumulation of CXCR4(+)VEGFR1(+) cells to the ulcer granulation tissues.","23809370","Aspirin","Matrix Metalloproteinase 9"]
["Aspirin","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","21474293",2012,"A therapeutic approach to treat cardiovascular dysfunction of diabetes.","21474293","Aspirin","Matrix Metalloproteinase 9"]
["Aspirin","Matrix Metalloproteinase 9",1,0,1,1,"MMP9","20728206",2010,"The effect of aspirin desensitization on novel biomarkers in aspirin-exacerbated respiratory diseases.","20728206","Aspirin","Matrix Metalloproteinase 9"]
["Aspirin","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","20137092",2010,"Regulations of the key mediators in inflammation and atherosclerosis by aspirin in human macrophages.","20137092","Aspirin","Matrix Metalloproteinase 9"]
["Aspirin","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","11681279",2001,"[Expression of pharyngeal- tumor- metastasis related genes and possibility of the gene therapy--Suppressive effects of aspirin on the tumor metastasis].","11681279","Aspirin","Matrix Metalloproteinase 9"]
["Aspirin","NF-E2-Related Factor 2",1,0,1,0,"NFE2L2","16267095",2006,"NO-donating aspirin induces phase II enzymes in vitro and in vivo.","16267095","Aspirin","NF-E2-Related Factor 2"]
["Aspirin","NF-E2-Related Factor 2",1,0,1,0,"NFE2L2","23035985",2012,"Quinone-induced activation of Keap1/Nrf2 signaling by aspirin prodrugs masquerading as nitric oxide.","23035985","Aspirin","NF-E2-Related Factor 2"]
["Aspirin","NF-E2-Related Factor 2",1,0,1,0,"NFE2L2","22209714",2012,"Hydrogen sulfide-releasing aspirin modulates xenobiotic metabolizing enzymes in vitro and in vivo.","22209714","Aspirin","NF-E2-Related Factor 2"]
["Aspirin","Receptors, Urokinase Plasminogen Activator",1,0,1,0,"PLAUR","16893520",2006,"Aspirin upregulates expression of urokinase type plasminogen activator receptor (uPAR) gene in human colon cancer cells through AP1.","16893520","Aspirin","Receptors, Urokinase Plasminogen Activator"]
["Aspirin","Serum Amyloid A Protein",1,0,1,0,"SAA1","17579083",2007,"Aspirin-triggered lipoxins override the apoptosis-delaying action of serum amyloid A in human neutrophils: a novel mechanism for resolution of inflammation.","17579083","Aspirin","Serum Amyloid A Protein"]
["Aspirin","Serum Amyloid A Protein",1,0,1,0,"SAA1","15763433",2005,"Cyclooxygenase-mediated prostaglandin F2alpha is decreased in an elderly population treated with low-dose aspirin.","15763433","Aspirin","Serum Amyloid A Protein"]
["Aspirin","E-Selectin",1,0,1,0,"SELE","12890715",2003,"Evidence that 5-lipoxygenase and acetylated cyclooxygenase 2-derived eicosanoids regulate leukocyte-endothelial adherence in response to aspirin.","12890715","Aspirin","E-Selectin"]
["Aspirin","E-Selectin",1,0,1,0,"SELE","19786240",2009,"Randomized controlled trial of aspirin and clopidogrel versus aspirin and placebo on markers of smooth muscle proliferation before and after peripheral angioplasty.","19786240","Aspirin","E-Selectin"]
["Aspirin","E-Selectin",1,0,1,0,"SELE","12919181",2003,"Pharmacodynamic characterization of the interaction between the glycoprotein IIb/IIIa inhibitor YM337 and unfractionated heparin and aspirin in humans.","12919181","Aspirin","E-Selectin"]
["Aspirin","E-Selectin",1,0,1,0,"SELE","11254909",2001,"Effects of heparin and aspirin on circulating P-selectin, E-selectin and von Willebrand Factor levels in healthy men.","11254909","Aspirin","E-Selectin"]
["Aspirin","E-Selectin",1,0,1,0,"SELE","15901601",2005,"Novel lipid mediator aspirin-triggered lipoxin A4 induces heme oxygenase-1 in endothelial cells.","15901601","Aspirin","E-Selectin"]
["Aspirin","E-Selectin",1,0,1,0,"SELE","22724630",2012,"Inducing apoptosis in rolling cancer cells: a combined therapy with aspirin and immobilized TRAIL and E-selectin.","22724630","Aspirin","E-Selectin"]
["Aspirin","E-Selectin",1,0,1,0,"SELE","7534663",1995,"Aspirin inhibits nuclear factor-kappa B mobilization and monocyte adhesion in stimulated human endothelial cells.","7534663","Aspirin","E-Selectin"]
["Aspirin","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","16676089",2006,"Increased plasma plasminogen activator inhibitor-1 levels caused by additional aspirin treatment.","16676089","Aspirin","Plasminogen Activator Inhibitor 1"]
["Aspirin","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","10753983",2000,"Effects of fixed low-dose warfarin, aspirin-warfarin combination therapy, and dose-adjusted warfarin on thrombogenesis in chronic atrial fibrillation.","10753983","Aspirin","Plasminogen Activator Inhibitor 1"]
["Aspirin","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","1390591",1992,"Modulation of fibrinolytic response to venous occlusion in humans by a combination of low-dose aspirin and n-3 polyunsaturated fatty acids.","1390591","Aspirin","Plasminogen Activator Inhibitor 1"]
["Aspirin","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","16421011",2006,"Effect of aspirin, clopidogrel and dipyridamole on soluble markers of vascular function in normal volunteers and patients with prior ischaemic stroke.","16421011","Aspirin","Plasminogen Activator Inhibitor 1"]
["Aspirin","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","1280469",1992,"Pharmacological modulation of the endotoxin-induced increase in plasminogen activator inhibitor activity in rats.","1280469","Aspirin","Plasminogen Activator Inhibitor 1"]
["Aspirin","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","10403685",1999,"Association of plasma levels of activated protein C with recanalization of the infarct-related coronary artery after thrombolytic therapy in acute myocardial infarction.","10403685","Aspirin","Plasminogen Activator Inhibitor 1"]
["Aspirin","Plasminogen Activator Inhibitor 1",1,0,1,1,"SERPINE1","23441445",2012,"Aspirin desensitization in a woman with inherited thrombophilia and recurrent miscarriage.","23441445","Aspirin","Plasminogen Activator Inhibitor 1"]
["Aspirin","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","21122850",2011,"Antiplatelet therapy effectively reduces plasma plasminogen activator inhibitor-1 levels.","21122850","Aspirin","Plasminogen Activator Inhibitor 1"]
["Aspirin","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","19174824",2009,"Prospective, observational study of antiplatelet and coagulation biomarkers as predictors of thromboembolic events after implantation of ventricular assist devices.","19174824","Aspirin","Plasminogen Activator Inhibitor 1"]
["Aspirin","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","8111770",1993,"Effect of single oral dose of aspirin on human platelet functions and plasma plasminogen activator inhibitor-1.","8111770","Aspirin","Plasminogen Activator Inhibitor 1"]
["Aspirin","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","7892894",1995,"Effect of low-dose aspirin during pregnancy on fibrinolytic variables before and after parturition.","7892894","Aspirin","Plasminogen Activator Inhibitor 1"]
["Aspirin","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","8506551",1993,"Coagulation-fibrinolysis system in poststroke patients receiving antiplatelet medication.","8506551","Aspirin","Plasminogen Activator Inhibitor 1"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L132,L132)","v":"Aspirin"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M132,M132)","v":"Plasminogen Activator Inhibitor 1"},1,0,1,0,"SERPINE1",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K132,K132)","v":"7718459"},1995,"The effect of aspirin on haemostatic activity in the treatment of chronic venous leg ulceration.","7718459","Aspirin","Plasminogen Activator Inhibitor 1"]
["Aspirin","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","8815563",1996,"Detection of a hypercoagulable state in nonvalvular atrial fibrillation and the effect of anticoagulant therapy.","8815563","Aspirin","Plasminogen Activator Inhibitor 1"]
["Aspirin","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","9857919",1998,"Better increase in fibrin gel porosity by low dose than intermediate dose acetylsalicylic acid.","9857919","Aspirin","Plasminogen Activator Inhibitor 1"]
["Aspirin","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","7513398",1994,"Effect of low dose aspirin on augmented plasminogen activator inhibitor type 1 activity in patients with permanent pacemakers.","7513398","Aspirin","Plasminogen Activator Inhibitor 1"]
["Aspirin","Receptors, Thromboxane A2, Prostaglandin H2",1,0,1,0,"TBXA2R","23688183",2013,"Polymorphisms and high on-aspirin platelet reactivity after off-pump coronary artery bypass grafting.","23688183","Aspirin","Receptors, Thromboxane A2, Prostaglandin H2"]
["Aspirin","Receptors, Thromboxane A2, Prostaglandin H2",1,0,1,0,"TBXA2R","15091003",2004,"Evaluation of anti-platelet aggregatory effects of aspirin, cilostazol and ramatroban on platelet-rich plasma and whole blood.","15091003","Aspirin","Receptors, Thromboxane A2, Prostaglandin H2"]
["Aspirin","Receptors, Thromboxane A2, Prostaglandin H2",1,0,1,0,"TBXA2R","21740787",2011,"Effect of polymorphism and type II diabetes on aspirin resistance in patients with unstable coronary artery disease.","21740787","Aspirin","Receptors, Thromboxane A2, Prostaglandin H2"]
["Aspirin","Receptors, Thromboxane A2, Prostaglandin H2",1,0,1,0,"TBXA2R","22101342",2012,"Thromboxane A2 receptor +795T&gt;C and chemoattractant receptor-homologous molecule expressed on Th2 cells -466T&gt;C gene polymorphisms in patients with aspirin-exacerbated respiratory disease.","22101342","Aspirin","Receptors, Thromboxane A2, Prostaglandin H2"]
["Aspirin","Receptors, Thromboxane A2, Prostaglandin H2",1,0,1,0,"TBXA2R","2145839",1990,"Platelet thromboxane A2/prostaglandin H2 receptors in human volunteers on low doses of aspirin.","2145839","Aspirin","Receptors, Thromboxane A2, Prostaglandin H2"]
["Aspirin","Receptors, Thromboxane A2, Prostaglandin H2",1,0,1,1,"TBXA2R","21070398",2011,"Association of thromboxane A2 receptor (TBXA2R) gene polymorphism in patients with aspirin-intolerant acute urticaria.","21070398","Aspirin","Receptors, Thromboxane A2, Prostaglandin H2"]
["Aspirin","Receptors, Thromboxane A2, Prostaglandin H2",1,0,1,0,"TBXA2R","18410117",2008,"Apigenin inhibits platelet adhesion and thrombus formation and synergizes with aspirin in the suppression of the arachidonic acid pathway.","18410117","Aspirin","Receptors, Thromboxane A2, Prostaglandin H2"]
["Aspirin","Receptors, Thromboxane A2, Prostaglandin H2",1,0,1,1,"TBXA2R","15505105",2004,"Anti-glycoprotein VI treatment severely compromises hemostasis in mice with reduced alpha2beta1 levels or concomitant aspirin therapy.","15505105","Aspirin","Receptors, Thromboxane A2, Prostaglandin H2"]
["Aspirin","Receptors, Thromboxane A2, Prostaglandin H2",1,0,1,0,"TBXA2R","17245331",2007,"Exploratory aspirin resistance trial in healthy Japanese volunteers (J-ART) using platelet aggregation as a measure of thrombogenicity.","17245331","Aspirin","Receptors, Thromboxane A2, Prostaglandin H2"]
["Aspirin","Receptors, Thromboxane A2, Prostaglandin H2",1,0,1,1,"TBXA2R","15898979",2005,"Association of thromboxane A2 receptor gene polymorphism with the phenotype of acetyl salicylic acid-intolerant asthma.","15898979","Aspirin","Receptors, Thromboxane A2, Prostaglandin H2"]
["Aspirin","Receptors, Thromboxane A2, Prostaglandin H2",1,0,1,0,"TBXA2R","9507752",1998,"Hemoglobin A0 and alpha-crosslinked hemoglobin (alpha-DBBF) potentiate agonist-induced platelet aggregation through the platelet thromboxane receptor.","9507752","Aspirin","Receptors, Thromboxane A2, Prostaglandin H2"]
["Aspirin","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","20940449",2011,"Angiostatic effects of aspirin in hypoxia-reoxygenation are linked to modulation of TGF?1 signaling.","20940449","Aspirin","Transforming Growth Factor beta1"]
["Aspirin","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","12566377",2003,"Acetylsalicylic acid inhibits cell proliferation by involving transforming growth factor-beta.","12566377","Aspirin","Transforming Growth Factor beta1"]
["Aspirin","Transforming Growth Factor beta1",1,0,1,1,"TGFB1","19138248",2008,"Association between a TGFbeta1 promoter polymorphism and the phenotype of aspirin-intolerant chronic urticaria in a Korean population.","19138248","Aspirin","Transforming Growth Factor beta1"]
["Aspirin","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","17300951",2006,"Effects of atorvastatin and aspirin combined therapy on inflammatory responses in patients undergoing coronary artery bypass grafting.","17300951","Aspirin","Transforming Growth Factor beta1"]
["Aspirin","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","21803431",2011,"Differential effect of clopidogrel and aspirin on the release of BDNF from platelets.","21803431","Aspirin","Transforming Growth Factor beta1"]
["Aspirin","Transforming Growth Factor beta1",1,0,1,1,"TGFB1","19222424",2009,"Combined effect of IL-10 and TGF-beta1 promoter polymorphisms as a risk factor for aspirin-intolerant asthma and rhinosinusitis.","19222424","Aspirin","Transforming Growth Factor beta1"]
["Aspirin","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","23306703",2013,"Acetyl salicylic acid inhibits Th17 airway inflammation via blockade of IL-6 and IL-17 positive feedback.","23306703","Aspirin","Transforming Growth Factor beta1"]
["Aspirin","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","14586741",2003,"Roles of connective tissue growth factor and prostanoids in early streptozotocin-induced diabetic rat kidney: the effect of aspirin treatment.","14586741","Aspirin","Transforming Growth Factor beta1"]
["Aspirin","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","20339548",2010,"Role of TGF-beta1 and MAP kinases in the antiproliferative effect of aspirin in human vascular smooth muscle cells.","20339548","Aspirin","Transforming Growth Factor beta1"]
["Aspirin","Thrombomodulin",1,0,1,0,"THBD","10051263",1999,"Regulation of adhesion molecules during human endotoxemia. No acute effects of aspirin.","10051263","Aspirin","Thrombomodulin"]
["Aspirin","Thrombomodulin",1,0,1,0,"THBD","17489881",2007,"Relationship between endothelial dysfunction, oxidant stress and aspirin resistance in patients with stable coronary heart disease.","17489881","Aspirin","Thrombomodulin"]
["Aspirin","Thrombomodulin",1,0,1,0,"THBD","20233808",2010,"Impaired anti-platelet effect of aspirin, inflammation and platelet turnover in cardiac surgery.","20233808","Aspirin","Thrombomodulin"]
["Aspirin","Thrombomodulin",1,0,1,0,"THBD","19260323",2008,"[Effects of puerarin with aspirin on the markers of damaged vascular endothelial cells in patients with acute cerebral infarction].","19260323","Aspirin","Thrombomodulin"]
["Aspirin","Tissue Inhibitor of Metalloproteinase-1",1,0,1,0,"TIMP1","16023759",2006,"Monocyte matrix and ADAM metalloproteinase expression in type 2 diabetes after aspirin therapy.","16023759","Aspirin","Tissue Inhibitor of Metalloproteinase-1"]
["Aspirin","Tissue Inhibitor of Metalloproteinase-1",1,0,1,0,"TIMP1","18971601",2009,"Aspirin inhibits MMP-2 and MMP-9 expressions and activities through upregulation of PPARalpha/gamma and TIMP gene expressions in ox-LDL-stimulated macrophages derived from human monocytes.","18971601","Aspirin","Tissue Inhibitor of Metalloproteinase-1"]
["Aspirin","Tissue Inhibitor of Metalloproteinase-1",1,0,1,1,"TIMP1","21962096",2011,"Variations in expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in nasal mucosa of aspirin-sensitive versus aspirin-tolerant patients with nasal polyposis.","21962096","Aspirin","Tissue Inhibitor of Metalloproteinase-1"]
["Aspirin","Tissue Inhibitor of Metalloproteinase-1",1,0,1,0,"TIMP1","19462226",2009,"Aspirin inhibits MMP-2 and MMP-9 expression and activity through PPARalpha/gamma and TIMP-1-mediated mechanisms in cultured mouse celiac macrophages.","19462226","Aspirin","Tissue Inhibitor of Metalloproteinase-1"]
["Aspirin","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","11481242",2001,"Aspirin inhibits NF-kappaB and protects from angiotensin II-induced organ damage.","11481242","Aspirin","Vascular Cell Adhesion Molecule-1"]
["Aspirin","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","15219202",2004,"Aspirin inhibits endothelial cell activation induced by antiphospholipid antibodies.","15219202","Aspirin","Vascular Cell Adhesion Molecule-1"]
["Aspirin","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","20877628",2010,"NO-donating aspirin and aspirin partially inhibit age-related atherosclerosis but not radiation-induced atherosclerosis in ApoE null mice.","20877628","Aspirin","Vascular Cell Adhesion Molecule-1"]
["Aspirin","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","10051263",1999,"Regulation of adhesion molecules during human endotoxemia. No acute effects of aspirin.","10051263","Aspirin","Vascular Cell Adhesion Molecule-1"]
["Aspirin","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","21397034",2011,"BM-573 inhibits the development of early atherosclerotic lesions in Apo E deficient mice by blocking TP receptors and thromboxane synthase.","21397034","Aspirin","Vascular Cell Adhesion Molecule-1"]
["Aspirin","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","17334512",2007,"Prevention by NCX 4016, a nitric oxide-donating aspirin, but not by aspirin, of the acute endothelial dysfunction induced by exercise in patients with intermittent claudication.","17334512","Aspirin","Vascular Cell Adhesion Molecule-1"]
["Aspirin","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","24709673",2014,"Aspirin-triggered resolvin D1 down-regulates inflammatory responses and protects against endotoxin-induced acute kidney injury.","24709673","Aspirin","Vascular Cell Adhesion Molecule-1"]
["Aspirin","Vascular Cell Adhesion Molecule-1",1,0,1,1,"VCAM1","16440541",2006,"Adhesion molecules and their ligands in nasal polyps of aspirin-hypersensitive patients.","16440541","Aspirin","Vascular Cell Adhesion Molecule-1"]
["Aspirin","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","15901601",2005,"Novel lipid mediator aspirin-triggered lipoxin A4 induces heme oxygenase-1 in endothelial cells.","15901601","Aspirin","Vascular Cell Adhesion Molecule-1"]
["Aspirin","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","12417048",2002,"Suppression of lung metastasis by aspirin but not indomethacin in an in vivo model of chemically induced hepatocellular carcinoma.","12417048","Aspirin","Vascular Cell Adhesion Molecule-1"]
["Aspirin","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","17239863",2007,"Aspirin prevents adhesion of T lymphoblasts to vascular smooth muscle cells.","17239863","Aspirin","Vascular Cell Adhesion Molecule-1"]
["Aspirin","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","21378140",2011,"Interaction with damaged vessel wall in vivo in humans induces platelets to express CD40L resulting in endothelial activation with no effect of aspirin intake.","21378140","Aspirin","Vascular Cell Adhesion Molecule-1"]
["Aspirin","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","7534663",1995,"Aspirin inhibits nuclear factor-kappa B mobilization and monocyte adhesion in stimulated human endothelial cells.","7534663","Aspirin","Vascular Cell Adhesion Molecule-1"]
["Atrazine","Receptor, Epidermal Growth Factor",1,1,1,1,"EGFR","14962502",2004,"Exposure parameters necessary for delayed puberty and mammary gland development in Long-Evans rats exposed in utero to atrazine.","14962502","Atrazine","Receptor, Epidermal Growth Factor"]
["bifenthrin","Receptors, LDL",1,0,1,1,"LDLR","23994515",2013,"Exposure of maternal mice to cis-bifenthrin enantioselectively disrupts the transcription of genes related to testosterone synthesis in male offspring.","23994515","bifenthrin","Receptors, LDL"]
["bis(tri-n-butyltin)oxide","NF-E2-Related Factor 2",0,0,0,1,"NFE2L2","24247028",2014,"DON shares a similar mode of action as the ribotoxic stress inducer anisomycin while TBTO shares ER stress patterns with the ER stress inducer thapsigargin based on comparative gene expression profiling in Jurkat T cells.","24247028","bis(tri-n-butyltin)oxide","NF-E2-Related Factor 2"]
["bisphenol A","Chemokine CCL2",1,1,1,1,"CCL2","12505275",2003,"Effect of Bisphenol A on non-specific immunodefenses against non-pathogenic Escherichia coli.","12505275","bisphenol A","Chemokine CCL2"]
["bisphenol A","Receptor, Epidermal Growth Factor",1,1,1,1,"EGFR","21813366",2011,"Low concentrations of bisphenol A induce mouse spermatogonial cell proliferation by G protein-coupled receptor 30 and estrogen receptor-?.","21813366","bisphenol A","Receptor, Epidermal Growth Factor"]
["bisphenol A","Receptor, Epidermal Growth Factor",1,1,1,0,"EGFR","21909620",2012,"Effect of bisphenol A on the EGFR-STAT3 pathway in MCF-7 breast cancer             cells.","21909620","bisphenol A","Receptor, Epidermal Growth Factor"]
["bisphenol A","Receptor, Epidermal Growth Factor",1,1,1,1,"EGFR","24495410",2014,"Involvement of activating ERK1/2 through G protein coupled receptor 30 and estrogen receptor ?/? in low doses of bisphenol A promoting growth of Sertoli TM4 cells.","24495410","bisphenol A","Receptor, Epidermal Growth Factor"]
["bisphenol A","Matrix Metalloproteinase 1",1,1,1,1,"MMP1","20600708",2010,"Bisphenol-A interferes with estradiol-mediated protection in osteoarthritic chondrocytes.","20600708","bisphenol A","Matrix Metalloproteinase 1"]
["bisphenol A","Matrix Metalloproteinase 9",1,1,1,1,"MMP9","18585891",2008,"Bisphenol A concentration-dependently increases human granulosa-lutein cell matrix metalloproteinase-9 (MMP-9) enzyme output.","18585891","bisphenol A","Matrix Metalloproteinase 9"]
["bisphenol A","Matrix Metalloproteinase 9",1,1,1,1,"MMP9","24997338",2014,"Bisphenol A induce ovarian cancer cell migration via the MAPK and PI3K/Akt signalling pathways.","24997338","bisphenol A","Matrix Metalloproteinase 9"]
["bisphenol A","NF-E2-Related Factor 2",1,1,1,0,"NFE2L2","23360430",2013,"Bisphenol A activates the Nrf1/2-antioxidant response element pathway in HEK 293 cells.","23360430","bisphenol A","NF-E2-Related Factor 2"]
["Busulfan","Chemokine CCL2",0,0,1,0,"CCL2","23423338",2013,"Busulfan conditioning enhances engraftment of hematopoietic donor-derived cells in the brain compared with irradiation.","23423338","Busulfan","Chemokine CCL2"]
["Busulfan","Antigens, CD40",0,0,1,0,"CD40","17162205",2006,"Apoptotic donor leukocytes limit mixed-chimerism induced by CD40-CD154 blockade in allogeneic bone marrow transplantation.","17162205","Busulfan","Antigens, CD40"]
["Busulfan","Antigens, CD40",0,0,1,0,"CD40","11441122",2001,"Costimulation blockade, busulfan, and bone marrow promote titratable macrochimerism, induce transplantation tolerance, and correct genetic hemoglobinopathies with minimal myelosuppression.","11441122","Busulfan","Antigens, CD40"]
["Busulfan","Macrophage Colony-Stimulating Factor",0,0,1,1,"CSF1","7508003",1993,"[Effect of G-CSF and M-CSF on busulfan-induced marrow failure in a 91-year old patient with essential thrombocythemia].","7508003","Busulfan","Macrophage Colony-Stimulating Factor"]
["Busulfan","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","22286157",2012,"Antineoplastic agent busulfan regulates a network of genes related to coagulation and fibrinolysis.","22286157","Busulfan","Plasminogen Activator Inhibitor 1"]
["Busulfan","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","22286157",2012,"Antineoplastic agent busulfan regulates a network of genes related to coagulation and fibrinolysis.","22286157","Busulfan","Transforming Growth Factor beta1"]
["Butylated Hydroxyanisole","NF-E2-Related Factor 2",1,1,0,0,"NFE2L2","21651925",2011,"Participation of covalent modification of Keap1 in the activation of Nrf2 by tert-butylbenzoquinone, an electrophilic metabolite of butylated hydroxyanisole.","21651925","Butylated Hydroxyanisole","NF-E2-Related Factor 2"]
["Butylated Hydroxyanisole","NF-E2-Related Factor 2",1,1,0,0,"NFE2L2","20194533",2010,"Up-regulation of human CYP2J2 in HepG2 cells by butylated hydroxyanisole is mediated by c-Jun and Nrf2.","20194533","Butylated Hydroxyanisole","NF-E2-Related Factor 2"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L196,L196)","v":"Butylated Hydroxyanisole"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M196,M196)","v":"NF-E2-Related Factor 2"},1,1,0,0,"NFE2L2",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K196,K196)","v":"18227147"},2008,"Markers of electrophilic stress caused by chemically reactive metabolites in human hepatocytes.","18227147","Butylated Hydroxyanisole","NF-E2-Related Factor 2"]
["Butylated Hydroxyanisole","NF-E2-Related Factor 2",1,1,0,0,"NFE2L2","10816095",2000,"The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin.","10816095","Butylated Hydroxyanisole","NF-E2-Related Factor 2"]
["Butylated Hydroxyanisole","NF-E2-Related Factor 2",1,1,0,0,"NFE2L2","17048120",2006,"Induction of heme oxygenase-1 (HO-1) and NAD[P]H: quinone oxidoreductase 1 (NQO1) by a phenolic antioxidant, butylated hydroxyanisole (BHA) and its metabolite, tert-butylhydroquinone (tBHQ) in primary-cultured human and rat hepatocytes.","17048120","Butylated Hydroxyanisole","NF-E2-Related Factor 2"]
["Butylated Hydroxyanisole","NF-E2-Related Factor 2",1,1,0,0,"NFE2L2","23247010",2013,"Regulation of human carbonyl reductase 1 (CBR1, SDR21C1) gene by transcription factor Nrf2.","23247010","Butylated Hydroxyanisole","NF-E2-Related Factor 2"]
["Butylated Hydroxyanisole","NF-E2-Related Factor 2",1,1,0,0,"NFE2L2","16739127",2006,"Butylated hydroxyanisole regulates ARE-mediated gene expression via Nrf2 coupled with ERK and JNK signaling pathway in HepG2 cells.","16739127","Butylated Hydroxyanisole","NF-E2-Related Factor 2"]
["Cacodylic Acid","Receptor, Epidermal Growth Factor",1,0,0,1,"EGFR","19429254",2009,"Effects of an epidermal growth factor receptor inhibitor on arsenic associated toxicity in the rat bladder epithelium.","19429254","Cacodylic Acid","Receptor, Epidermal Growth Factor"]
["Caffeine","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","2058791",1991,"Interactive effects of ethanol and caffeine on rat fetal hepatocyte replication and EGF receptor expression.","2058791","Caffeine","Receptor, Epidermal Growth Factor"]
["Caffeine","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","18346049",2008,"Caffeine inhibits the proliferation of liver cancer cells and activates the MEK/ERK/EGFR signalling pathway.","18346049","Caffeine","Receptor, Epidermal Growth Factor"]
["Caffeine","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","7911844",1994,"Greater enhancement of chemosensitivity by caffeine in high-p185neu-expressing human non-small-cell lung cancer cell lines.","7911844","Caffeine","Receptor, Epidermal Growth Factor"]
["Caffeine","Receptors, LDL",0,0,1,0,"LDLR","22504320",2012,"Enhanced brain amyloid-? clearance by rifampicin and caffeine as a possible protective mechanism against Alzheimer's disease.","22504320","Caffeine","Receptors, LDL"]
["Caffeine","Receptors, LDL",0,0,1,0,"LDLR","23615262",2013,"Caffeine attenuates lipid accumulation via activation of AMP-activated protein kinase signaling pathway in HepG2 cells.","23615262","Caffeine","Receptors, LDL"]
["Caffeine","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","18808450",2008,"Caffeine protects against MPTP-induced blood-brain barrier dysfunction in mouse striatum.","18808450","Caffeine","Matrix Metalloproteinase 9"]
["Caffeine","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","20432471",2010,"Caffeine induces matrix metalloproteinase-2 (MMP-2) and MMP-9 down-regulation in human leukemia U937 cells via Ca2+/ROS-mediated suppression of ERK/c-fos pathway and activation of p38 MAPK/c-jun pathway.","20432471","Caffeine","Matrix Metalloproteinase 9"]
["Caffeine","NF-E2-Related Factor 2",0,0,1,0,"NFE2L2","24379627",2013,"Nrf2 and Snail-1 in the prevention of experimental liver fibrosis by caffeine.","24379627","Caffeine","NF-E2-Related Factor 2"]
["Caffeine","NF-E2-Related Factor 2",0,0,1,0,"NFE2L2","20410106",2010,"Decaffeinated coffee and nicotine-free tobacco provide neuroprotection in Drosophila models of Parkinson's disease through an NRF2-dependent mechanism.","20410106","Caffeine","NF-E2-Related Factor 2"]
["Caffeine","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","22646289",2012,"Coffee and caffeine protect against liver injury induced by thioacetamide in male Wistar rats.","22646289","Caffeine","Transforming Growth Factor beta1"]
["Caffeine","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","24379627",2013,"Nrf2 and Snail-1 in the prevention of experimental liver fibrosis by caffeine.","24379627","Caffeine","Transforming Growth Factor beta1"]
["Caffeine","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","7514535",1994,"Methylxanthines and calcium-mobilizing agents inhibit the expression of cytokine-inducible nitric oxide synthase and vascular cell adhesion molecule-1 in murine microvascular endothelial cells.","7514535","Caffeine","Vascular Cell Adhesion Molecule-1"]
["Caprolactam","Matrix Metalloproteinase 1",0,0,1,0,"MMP1","9873489",1998,"Design and synthesis of conformationally-constrained MMP inhibitors.","9873489","Caprolactam","Matrix Metalloproteinase 1"]
["Carbamazepine","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","21169035",2011,"Effects of chronic treatment with valproate and oxcarbazepine on testicular development in rats.","21169035","Carbamazepine","Transforming Growth Factor beta1"]
["celecoxib","Chemokine CCL2",0,0,1,0,"CCL2","14522423",2003,"Chronic inhibition of cyclooxygenase-2 does not alter plaque composition in a mouse model of advanced unstable atherosclerosis.","14522423","celecoxib","Chemokine CCL2"]
["celecoxib","Chemokine CCL2",0,0,1,0,"CCL2","15613981",2005,"Celecoxib, a selective cyclooxygenase-2 inhibitor, decreases monocyte chemoattractant protein-1 expression and neointimal hyperplasia in the rabbit atherosclerotic balloon injury model.","15613981","celecoxib","Chemokine CCL2"]
["celecoxib","Chemokine CCL2",0,0,1,0,"CCL2","20039930",2010,"Suppressive effect of COX2 inhibitor on the progression of adipose inflammation in high-fat-induced obese rats.","20039930","celecoxib","Chemokine CCL2"]
["celecoxib","Chemokine CCL2",0,0,1,0,"CCL2","16835249",2006,"Selective COX-2 inhibitor celecoxib prevents experimental autoimmune encephalomyelitis through COX-2-independent pathway.","16835249","celecoxib","Chemokine CCL2"]
["celecoxib","Chemokine CCL2",0,0,1,0,"CCL2","20538289",2010,"Celecoxib combined with atorvastatin prevents progression of atherosclerosis.","20538289","celecoxib","Chemokine CCL2"]
["celecoxib","Collagen Type III",0,0,1,0,"COL3A1","17364667",2007,"Effects of celecoxib on migration, proliferation and collagen expression of tendon cells.","17364667","celecoxib","Collagen Type III"]
["celecoxib","Macrophage Colony-Stimulating Factor",0,0,1,0,"CSF1","20204061",2009,"IL-1beta suppresses the formation of osteoclasts by increasing OPG production via an autocrine mechanism involving celecoxib-related prostaglandins in chondrocytes.","20204061","celecoxib","Macrophage Colony-Stimulating Factor"]
["celecoxib","Macrophage Colony-Stimulating Factor",0,0,1,0,"CSF1","19198759",2009,"The effect of selective cyclooxygenase-2 inhibitor on human osteoclast precursors to influence osteoclastogenesis in vitro.","19198759","celecoxib","Macrophage Colony-Stimulating Factor"]
["celecoxib","Macrophage Colony-Stimulating Factor",0,0,1,0,"CSF1","22903384",2013,"Primary tumor regulates the pulmonary microenvironment in melanoma carcinoma model and facilitates lung metastasis.","22903384","celecoxib","Macrophage Colony-Stimulating Factor"]
["celecoxib","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","23010081",2013,"Celecoxib induces proliferation and Amphiregulin production in colon subepithelial myofibroblasts, activating erk1-2 signaling in synergy with EGFR.","23010081","celecoxib","Receptor, Epidermal Growth Factor"]
["celecoxib","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","21246519",2011,"Phase 1 trial of concurrent erlotinib, celecoxib, and reirradiation for recurrent head and neck cancer.","21246519","celecoxib","Receptor, Epidermal Growth Factor"]
["celecoxib","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","22990204",2012,"OSU-03012 interacts with lapatinib to kill brain cancer cells.","22990204","celecoxib","Receptor, Epidermal Growth Factor"]
["celecoxib","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","21882253",2012,"Celecoxib inactivates epithelial-mesenchymal transition stimulated by hypoxia and/or epidermal growth factor in colon cancer cells.","21882253","celecoxib","Receptor, Epidermal Growth Factor"]
["celecoxib","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","17996386",2008,"Celecoxib induced tumor cell radiosensitization by inhibiting radiation induced nuclear EGFR transport and DNA-repair: a COX-2 independent mechanism.","17996386","celecoxib","Receptor, Epidermal Growth Factor"]
["celecoxib","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","17909047",2007,"Targeting cyclooxygenase-2 and the epidermal growth factor receptor for the prevention and treatment of intestinal cancer.","17909047","celecoxib","Receptor, Epidermal Growth Factor"]
["celecoxib","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","19174577",2009,"Prevention of tumorigenesis in p53-null mammary epithelium by rexinoid bexarotene, tyrosine kinase inhibitor gefitinib, and celecoxib.","19174577","celecoxib","Receptor, Epidermal Growth Factor"]
["celecoxib","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","17908994",2007,"Exisulind in combination with celecoxib modulates epidermal growth factor receptor, cyclooxygenase-2, and cyclin D1 against prostate carcinogenesis: in vivo evidence.","17908994","celecoxib","Receptor, Epidermal Growth Factor"]
["celecoxib","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","19138272",2008,"Combination of an EGFR blocker and a COX-2 inhibitor for the treatment of advanced cutaneous squamous cell carcinoma.","19138272","celecoxib","Receptor, Epidermal Growth Factor"]
["celecoxib","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","23422093",2013,"Chemoprevention of head and neck cancer by simultaneous blocking of epidermal growth factor receptor and cyclooxygenase-2 signaling pathways: preclinical and clinical studies.","23422093","celecoxib","Receptor, Epidermal Growth Factor"]
["celecoxib","Receptor, Epidermal Growth Factor",0,0,1,1,"EGFR","16740761",2006,"A phase I trial to determine the optimal biological dose of celecoxib when combined with erlotinib in advanced non-small cell lung cancer.","16740761","celecoxib","Receptor, Epidermal Growth Factor"]
["celecoxib","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","16144906",2005,"Combined targeting of the epidermal growth factor receptor and cyclooxygenase-2 pathways.","16144906","celecoxib","Receptor, Epidermal Growth Factor"]
["celecoxib","Receptor, Epidermal Growth Factor",0,0,1,1,"EGFR","21217396",2011,"Dual blockade of the EGFR and COX-2 pathways: a phase II trial of cetuximab and celecoxib in patients with chemotherapy refractory metastatic colorectal cancer.","21217396","celecoxib","Receptor, Epidermal Growth Factor"]
["celecoxib","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","19098866",2009,"Expression pattern and functional relevance of epidermal growth factor receptor and cyclooxygenase-2: novel chemotherapeutic targets in pancreatic endocrine tumors?","19098866","celecoxib","Receptor, Epidermal Growth Factor"]
["celecoxib","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","19174580",2009,"Identification of modulated genes by three classes of chemopreventive agents at preneoplastic stages in a p53-null mouse mammary tumor model.","19174580","celecoxib","Receptor, Epidermal Growth Factor"]
["celecoxib","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","20120857",2009,"[The effect of simultaneously blocking target epidermal growth factor receptor tyrosine kinase and cyclooxygenase-2 on the growth of NPC cell].","20120857","celecoxib","Receptor, Epidermal Growth Factor"]
["celecoxib","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","22252523",2012,"Antiproliferative effects of selective cyclooxygenase-2 inhibitor modulated by nimotuzumab in estrogen-dependent breast cancer cells.","22252523","celecoxib","Receptor, Epidermal Growth Factor"]
["celecoxib","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","24528083",2014,"Simultaneous blockage of epidermal growth factor receptor and cyclooxygenase-2 in a human xenotransplanted lung cancer model.","24528083","celecoxib","Receptor, Epidermal Growth Factor"]
["celecoxib","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","20848776",2010,"[Effects of EGFR inhibitor AG1478 in combination with celecoxib on the growth of gastric cancer cells].","20848776","celecoxib","Receptor, Epidermal Growth Factor"]
["celecoxib","Matrix Metalloproteinase 1",0,0,1,0,"MMP1","18080123",2008,"Celecoxib inhibits production of MMP and NO via down-regulation of NF-kappaB and JNK in a PGE2 independent manner in human articular chondrocytes.","18080123","celecoxib","Matrix Metalloproteinase 1"]
["celecoxib","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","21587257",2011,"Continuous low-dose cyclophosphamide and methotrexate combined with celecoxib for patients with advanced cancer.","21587257","celecoxib","Matrix Metalloproteinase 9"]
["celecoxib","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","18435714",2009,"The anti-inflammatory effect of celecoxib does not prevent liver fibrosis in bile duct-ligated rats.","18435714","celecoxib","Matrix Metalloproteinase 9"]
["celecoxib","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","20524983",2010,"Antifibrotic and fibrolytic properties of celecoxib in liver damage induced by carbon tetrachloride in the rat.","20524983","celecoxib","Matrix Metalloproteinase 9"]
["celecoxib","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","23149858",2013,"Angiostatic properties of sulindac and celecoxib in the experimentally induced inflammatory colorectal cancer.","23149858","celecoxib","Matrix Metalloproteinase 9"]
["celecoxib","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","24374173",2014,"Celecoxib potentially inhibits metastasis of lung cancer promoted by surgery in mice, via suppression of the PGE2-modulated ?-catenin pathway.","24374173","celecoxib","Matrix Metalloproteinase 9"]
["celecoxib","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","15613981",2005,"Celecoxib, a selective cyclooxygenase-2 inhibitor, decreases monocyte chemoattractant protein-1 expression and neointimal hyperplasia in the rabbit atherosclerotic balloon injury model.","15613981","celecoxib","Matrix Metalloproteinase 9"]
["celecoxib","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","22922496",2012,"AEE788 potentiates celecoxib-induced growth inhibition and apoptosis in human colon cancer cells.","22922496","celecoxib","Matrix Metalloproteinase 9"]
["celecoxib","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","24640603",2014,"Cyclooxygenase-2 inhibitor celecoxib suppresses invasion and migration of nasopharyngeal carcinoma cell lines through a decrease in matrix metalloproteinase-2 and -9 activity.","24640603","celecoxib","Matrix Metalloproteinase 9"]
["celecoxib","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","20937352",2011,"Interleukin-17A induces cathepsin K and MMP-9 expression in osteoclasts via celecoxib-blocked prostaglandin E2 in osteoblasts.","20937352","celecoxib","Matrix Metalloproteinase 9"]
["celecoxib","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","20538289",2010,"Celecoxib combined with atorvastatin prevents progression of atherosclerosis.","20538289","celecoxib","Matrix Metalloproteinase 9"]
["celecoxib","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","15668523",2005,"Effect of maternal administration of selective cyclooxygenase (COX)-2 inhibitors on renal size, growth factors, proteinases, and COX-2 secretion in the fetal rabbit.","15668523","celecoxib","Matrix Metalloproteinase 9"]
["celecoxib","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","18771351",2008,"The combined effects of celecoxib and minocycline hydrochloride on inhibiting the osseous metastasis of breast cancer in nude mice.","18771351","celecoxib","Matrix Metalloproteinase 9"]
["celecoxib","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","15256475",2004,"Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates activation of cigarette smoke-induced nuclear factor (NF)-kappaB by suppressing activation of IkappaBalpha kinase in human non-small cell lung carcinoma: correlation with suppression of cyclin D1, COX-2, and matrix metalloproteinase-9.","15256475","celecoxib","Matrix Metalloproteinase 9"]
["celecoxib","NF-E2-Related Factor 2",0,0,1,0,"NFE2L2","20083195",2010,"Celecoxib activates PI-3K/Akt and mitochondrial redox signaling to enhance heme oxygenase-1-mediated anti-inflammatory activity in vascular endothelium.","20083195","celecoxib","NF-E2-Related Factor 2"]
["celecoxib","Serum Amyloid A Protein",0,0,1,0,"SAA1","18552508",2009,"Celecoxib inhibits serum amyloid a-induced matrix metalloproteinase-10 expression in human endothelial cells.","18552508","celecoxib","Serum Amyloid A Protein"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L260,L260)","v":"celecoxib"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M260,M260)","v":"Plasminogen Activator Inhibitor 1"},0,0,1,1,"SERPINE1",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K260,K260)","v":"18922176"},2008,"uPA is upregulated by high dose celecoxib in women at increased risk of developing breast cancer.","18922176","celecoxib","Plasminogen Activator Inhibitor 1"]
["celecoxib","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","23172668",2013,"Selective Cox-2 inhibitor celecoxib induces epithelial-mesenchymal transition in human lung cancer cells via activating MEK-ERK signaling.","23172668","celecoxib","Transforming Growth Factor beta1"]
["celecoxib","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","22200683",2012,"Celecoxib suppresses fibroblast proliferation and collagen expression             by inhibiting ERK1/2 and SMAD2/3 phosphorylation.","22200683","celecoxib","Transforming Growth Factor beta1"]
["celecoxib","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","22209876",2012,"Effect of celecoxib on proliferation, collagen expression, ERK1/2 and SMAD2/3 phosphorylation in NIH/3T3 fibroblasts.","22209876","celecoxib","Transforming Growth Factor beta1"]
["celecoxib","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","24462674",2014,"Celecoxib offsets the negative renal influences of cyclosporine via modulation of the TGF-?1/IL-2/COX-2/endothelin ET(B) receptor cascade.","24462674","celecoxib","Transforming Growth Factor beta1"]
["celecoxib","Thrombomodulin",0,0,1,1,"THBD","17916229",2007,"Effects of selective COX-2 inhibition on prostanoids and platelet physiology in young healthy volunteers.","17916229","celecoxib","Thrombomodulin"]
["celecoxib","Tissue Inhibitor of Metalloproteinase-1",0,0,1,0,"TIMP1","15668523",2005,"Effect of maternal administration of selective cyclooxygenase (COX)-2 inhibitors on renal size, growth factors, proteinases, and COX-2 secretion in the fetal rabbit.","15668523","celecoxib","Tissue Inhibitor of Metalloproteinase-1"]
["celecoxib","Tissue Inhibitor of Metalloproteinase-1",0,0,1,0,"TIMP1","18834249",2008,"The effects of selective COX-2 inhibitor/celecoxib and omega-3 fatty acid on matrix metalloproteinases, TIMP-1, and laminin-5gamma2-chain immunolocalization in experimental periodontitis.","18834249","celecoxib","Tissue Inhibitor of Metalloproteinase-1"]
["celecoxib","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","20083195",2010,"Celecoxib activates PI-3K/Akt and mitochondrial redox signaling to enhance heme oxygenase-1-mediated anti-inflammatory activity in vascular endothelium.","20083195","celecoxib","Vascular Cell Adhesion Molecule-1"]
["celecoxib","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","21425947",2011,"Preparation and in vitro evaluation of anti-VCAM-1-Fab'-conjugated liposomes for the targeted delivery of the poorly water-soluble drug celecoxib.","21425947","celecoxib","Vascular Cell Adhesion Molecule-1"]
["celecoxib","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","18084316",2008,"Celecoxib modulates adhesion of HT29 colon cancer cells to vascular endothelial cells by inhibiting ICAM-1 and VCAM-1 expression.","18084316","celecoxib","Vascular Cell Adhesion Molecule-1"]
["celecoxib","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","20538289",2010,"Celecoxib combined with atorvastatin prevents progression of atherosclerosis.","20538289","celecoxib","Vascular Cell Adhesion Molecule-1"]
["celecoxib","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","17950326",2008,"The select cyclooxygenase-2 inhibitor celecoxib reduced the extent of atherosclerosis in apo E-/- mice.","17950326","celecoxib","Vascular Cell Adhesion Molecule-1"]
["celecoxib","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","18084318",2008,"Celecoxib decreases expression of the adhesion molecules ICAM-1 and VCAM-1 in a colon cancer cell line (HT29).","18084318","celecoxib","Vascular Cell Adhesion Molecule-1"]
["Chlorpromazine","Receptor, Epidermal Growth Factor",1,1,1,0,"EGFR","3491545",1986,"Effects of phenothiazines on binding and processing of epidermal growth factor in 3T3 cells.","3491545","Chlorpromazine","Receptor, Epidermal Growth Factor"]
["Chlorpromazine","Receptor, Epidermal Growth Factor",1,1,1,0,"EGFR","15332124",2004,"Biglycan is internalized via a chlorpromazine-sensitive route.","15332124","Chlorpromazine","Receptor, Epidermal Growth Factor"]
["Chlorpromazine","Serum Amyloid A Protein",1,1,1,0,"SAA1","1814847",1991,"Chlorpromazine protection against interleukin-1 and tumor necrosis factor-mediated activities in vivo.","1814847","Chlorpromazine","Serum Amyloid A Protein"]
["Chlorpyrifos","NF-E2-Related Factor 2",0,0,1,1,"NFE2L2","23850137",2013,"The organophosphate chlorpyrifos disturbs redox balance and triggers antioxidant defense mechanisms in JEG-3 cells.","23850137","Chlorpyrifos","NF-E2-Related Factor 2"]
["citral","Chemokine CCL2",1,0,1,0,"CCL2","24069362",2013,"Citral is renoprotective for focal segmental glomerulosclerosis by inhibiting oxidative stress and apoptosis and activating Nrf2 pathway in mice.","24069362","citral","Chemokine CCL2"]
["citral","NF-E2-Related Factor 2",1,0,1,0,"NFE2L2","24069362",2013,"Citral is renoprotective for focal segmental glomerulosclerosis by inhibiting oxidative stress and apoptosis and activating Nrf2 pathway in mice.","24069362","citral","NF-E2-Related Factor 2"]
["Corticosterone","Chemokine CCL2",0,0,1,1,"CCL2","24468157",2014,"Corticosterone accelerates atherosclerosis in the apolipoprotein E-deficient mouse.","24468157","Corticosterone","Chemokine CCL2"]
["Corticosterone","Chemokine CCL2",0,0,1,0,"CCL2","16504399",2006,"Corticosterone regulates expression of CCL2 in the intact and chemically injured hippocampus.","16504399","Corticosterone","Chemokine CCL2"]
["Corticosterone","Chemokine CCL2",0,0,1,0,"CCL2","22960608",2013,"Chronic restraint stress in rats causes sustained increase in urinary corticosterone excretion without affecting cerebral or systemic oxidatively generated DNA/RNA damage.","22960608","Corticosterone","Chemokine CCL2"]
["Corticosterone","Chemokine CCL2",0,0,1,0,"CCL2","19958164",2010,"Cytokine and chemokine gene expression profiles in heterophils from chickens treated with corticosterone.","19958164","Corticosterone","Chemokine CCL2"]
["Corticosterone","Chemokine CCL2",0,0,1,0,"CCL2","21262246",2011,"Regulation by chronic-mild stress of glucocorticoids, monocyte chemoattractant protein-1 and adiposity in rats fed on a high-fat diet.","21262246","Corticosterone","Chemokine CCL2"]
["Corticosterone","Chemokine CCL2",0,0,1,0,"CCL2","9058763",1997,"Restraint stress-induced elevation of endogenous glucocorticoid suppresses migration of granulocytes and macrophages to an inflammatory locus.","9058763","Corticosterone","Chemokine CCL2"]
["Corticosterone","Collagen Type III",0,0,1,1,"COL3A1","25129992",2014,"Glucocorticoids activate cardiac mineralocorticoid receptors in adrenalectomized Dahl salt-sensitive rats.","25129992","Corticosterone","Collagen Type III"]
["Corticosterone","Receptors, LDL",0,0,1,0,"LDLR","21146149",2011,"Effect of high-dose total body irradiation on ACTH, corticosterone, and catecholamines in the rat.","21146149","Corticosterone","Receptors, LDL"]
["Corticosterone","Receptors, LDL",0,0,1,0,"LDLR","23485866",2013,"Effects of age on ACTH, corticosterone, glucose, insulin, and mRNA levels during intermittent hypoxia in the neonatal rat.","23485866","Corticosterone","Receptors, LDL"]
["Corticosterone","Receptors, LDL",0,0,1,0,"LDLR","16368783",2006,"Attenuated corticosterone response to chronic ACTH stimulation in hepatic lipase-deficient mice: evidence for a role for hepatic lipase in adrenal physiology.","16368783","Corticosterone","Receptors, LDL"]
["Corticosterone","Receptors, LDL",0,0,1,0,"LDLR","18703410",2008,"Development of the ACTH and corticosterone response to acute hypoxia in the neonatal rat.","18703410","Corticosterone","Receptors, LDL"]
["Corticosterone","Receptors, LDL",0,0,1,0,"LDLR","16461760",2006,"Cholesterol substrate pools and steroid hormone levels are normal in the face of mutational inactivation of NPC1 protein.","16461760","Corticosterone","Receptors, LDL"]
["Corticosterone","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","24880571",2014,"Differential regulation of bladder cancer growth by various glucocorticoids: corticosterone and prednisone inhibit cell invasion without promoting cell proliferation or reducing cisplatin cytotoxicity.","24880571","Corticosterone","Matrix Metalloproteinase 9"]
["Corticosterone","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","18931068",2008,"Corticosteroids modulate Seoul virus infection, regulatory T-cell responses and matrix metalloprotease 9 expression in male, but not female, Norway rats.","18931068","Corticosterone","Matrix Metalloproteinase 9"]
["Corticosterone","Serum Amyloid A Protein",0,0,1,0,"SAA1","10427685",1999,"Serum amyloid A, cytokines, and corticosterone responses in germfree and conventional mice after lipopolysaccharide injection.","10427685","Corticosterone","Serum Amyloid A Protein"]
["Corticosterone","Serum Amyloid A Protein",0,0,1,0,"SAA1","17631399",2008,"Evaluation of serum cortisol, metabolic parameters, acute phase proteins and faecal corticosterone as indicators of stress in cows.","17631399","Corticosterone","Serum Amyloid A Protein"]
["Corticosterone","Serum Amyloid A Protein",0,0,1,0,"SAA1","7780034",1995,"Ciliary neurotrophic factor (CNTF) induces serum amyloid A, hypoglycaemia and anorexia, and potentiates IL-1 induced corticosterone and IL-6 production in mice.","7780034","Corticosterone","Serum Amyloid A Protein"]
["Corticosterone","Serum Amyloid A Protein",0,0,1,0,"SAA1","8634432",1996,"Six different cytokines that share GP130 as a receptor subunit, induce serum amyloid A and potentiate the induction of interleukin-6 and the activation of the hypothalamus-pituitary-adrenal axis by interleukin-1.","8634432","Corticosterone","Serum Amyloid A Protein"]
["Corticosterone","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","16712723",2006,"Adrenalectomy promotes a permanent decrease of plasma corticoid levels and a transient increase of apoptosis and the expression of Transforming Growth Factor beta1 (TGF-beta1) in hippocampus: effect of a TGF-beta1 oligo-antisense.","16712723","Corticosterone","Transforming Growth Factor beta1"]
["cyanuric acid","Tissue Inhibitor of Metalloproteinase-1",0,0,0,1,"TIMP1","21784140",2011,"Gene expression of biomarkers of nephrotoxicity in F344 rats co-exposed to melamine and cyanuric acid for seven days.","21784140","cyanuric acid","Tissue Inhibitor of Metalloproteinase-1"]
["cyanuric acid","Tissue Inhibitor of Metalloproteinase-1",0,0,0,1,"TIMP1","23022069",2013,"Performance of urinary and gene expression biomarkers in detecting the nephrotoxic effects of melamine and cyanuric acid following diverse scenarios of co-exposure.","23022069","cyanuric acid","Tissue Inhibitor of Metalloproteinase-1"]
["cypermethrin","Receptor, Epidermal Growth Factor",1,0,1,1,"EGFR","22048644",2012,"Cypermethrin induces astrocyte apoptosis by the disruption of the autocrine/paracrine mode of epidermal growth factor receptor signaling.","22048644","cypermethrin","Receptor, Epidermal Growth Factor"]
["Dapsone","NF-E2-Related Factor 2",0,0,1,1,"NFE2L2","22970684",2013,"Changes in gene expression induced by aromatic amine drugs: testing the danger hypothesis.","22970684","Dapsone","NF-E2-Related Factor 2"]
["DDT","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","9321967",1997,"Differential effects of aroclors and DDT on growth factor gene expression and receptor tyrosine kinase activity in human breast epithelial cells.","9321967","DDT","Receptor, Epidermal Growth Factor"]
["DDT","Receptors, LDL",0,0,1,0,"LDLR","3111474",1987,"Uptake of persistent environmental chemicals by cultured human cells.","3111474","DDT","Receptors, LDL"]
["decamethrin","Macrophage Colony-Stimulating Factor",0,0,1,1,"CSF1","8257942",1993,"Effects of deltamethrin on the growth and differentiation of bone marrow hematopoietic stem cells.","8257942","decamethrin","Macrophage Colony-Stimulating Factor"]
["decamethrin","NF-E2-Related Factor 2",0,0,1,1,"NFE2L2","21398409",2011,"The pesticide deltamethrin increases free radical production and promotes nuclear translocation of the stress response transcription factor Nrf2 in rat brain.","21398409","decamethrin","NF-E2-Related Factor 2"]
["decamethrin","NF-E2-Related Factor 2",0,0,1,0,"NFE2L2","17540521",2007,"Transcription factor Nrf2 activation by deltamethrin in PC12 cells: Involvement of ROS.","17540521","decamethrin","NF-E2-Related Factor 2"]
["decamethrin","NF-E2-Related Factor 2",0,0,1,1,"NFE2L2","17676812",2007,"NF-E2 related factor 2 activation and heme oxygenase-1 induction by tert-butylhydroquinone protect against deltamethrin-mediated oxidative stress in PC12 cells.","17676812","decamethrin","NF-E2-Related Factor 2"]
["decamethrin","NF-E2-Related Factor 2",0,0,1,1,"NFE2L2","16737586",2006,"[Effects of deltamethrin on gene expression of some antioxidase, gamma glutamylcysteine synthetase and NFE2 related factor 2 (Nrf2) in brain tissue].","16737586","decamethrin","NF-E2-Related Factor 2"]
["decamethrin","NF-E2-Related Factor 2",0,0,1,1,"NFE2L2","20137388",2009,"[Effect of deltamethrin on production of free radical and transcription factor Nrf2 in rats' brain tissue].","20137388","decamethrin","NF-E2-Related Factor 2"]
["decamethrin","NF-E2-Related Factor 2",0,0,1,1,"NFE2L2","16758951",2006,"[Time course of gene expression of gamma-glutamylcysteine synthetase subunit and Nrf2 in brain tissues of rats exposed by deltamethrin].","16758951","decamethrin","NF-E2-Related Factor 2"]
["Dibutyl Phthalate","Matrix Metalloproteinase 9",1,0,1,1,"MMP9","19549552",2009,"Long-term effects of developmental exposure to di-n-butyl-phthalate (DBP) on rat prostate: proliferative and inflammatory disorders and a possible role of androgens.","19549552","Dibutyl Phthalate","Matrix Metalloproteinase 9"]
["Dibutyl Phthalate","Matrix Metalloproteinase 9",1,0,1,1,"MMP9","14977011",2003,"[Safety evaluation of chemicals by their effect on mRNA levels of the factors participating in the decomposition of liver extracellular matrix].","14977011","Dibutyl Phthalate","Matrix Metalloproteinase 9"]
["Dibutyl Phthalate","NF-E2-Related Factor 2",1,0,1,1,"NFE2L2","15192340",2004,"B6C3F1 mice exposed to ozone with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone and/or dibutyl phthalate showed toxicities through alterations of NF-kappaB, AP-1, Nrf2, and osteopontin.","15192340","Dibutyl Phthalate","NF-E2-Related Factor 2"]
["Dibutyl Phthalate","Receptors, Urokinase Plasminogen Activator",1,0,1,1,"PLAUR","14977011",2003,"[Safety evaluation of chemicals by their effect on mRNA levels of the factors participating in the decomposition of liver extracellular matrix].","14977011","Dibutyl Phthalate","Receptors, Urokinase Plasminogen Activator"]
["Dibutyl Phthalate","Plasminogen Activator Inhibitor 1",1,0,1,1,"SERPINE1","12565198",2003,"Changes in peroxisome proliferator-activated receptor gamma-regulated gene expression and inhibin/activin-follistatin system gene expression in rat testis after an administration of di-n-butyl phthalate.","12565198","Dibutyl Phthalate","Plasminogen Activator Inhibitor 1"]
["Diclofenac","Chemokine CCL2",0,0,1,0,"CCL2","12379530",2002,"Modulation of cell recruitment by anti-inflammatory agents in antigen-induced arthritis.","12379530","Diclofenac","Chemokine CCL2"]
["Diclofenac","Chemokine CCL2",0,0,1,0,"CCL2","21268133",2011,"Diclofenac, a selective COX-2 inhibitor, inhibits DMH-induced colon tumorigenesis through suppression of MCP-1, MIP-1? and VEGF.","21268133","Diclofenac","Chemokine CCL2"]
["Diclofenac","Collagen Type III",0,0,1,1,"COL3A1","12917183",2003,"Late corneal perforation after photorefractive keratectomy associated with topical diclofenac: involvement of matrix metalloproteinases.","12917183","Diclofenac","Collagen Type III"]
["Diclofenac","Matrix Metalloproteinase 1",0,0,1,0,"MMP1","10807502",2000,"A major metabolite of aceclofenac, 4'-hydroxy aceclofenac, suppresses the production of interstitial pro-collagenase/proMMP-1 and pro-stromelysin-1/proMMP-3 by human rheumatoid synovial cells.","10807502","Diclofenac","Matrix Metalloproteinase 1"]
["Diclofenac","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","7875305",1995,"Cyclooxygenase inhibitors augment the production of pro-matrix metalloproteinase 9 (progelatinase B) in rabbit articular chondrocytes.","7875305","Diclofenac","Matrix Metalloproteinase 9"]
["Diclofenac","Serum Amyloid A Protein",0,0,1,1,"SAA1","7543348",1995,"A comparative study of tenidap, a cytokine-modulating anti-rheumatic drug, and diclofenac in rheumatoid arthritis: a 24-week analysis of a 1-year clinical trial.","7543348","Diclofenac","Serum Amyloid A Protein"]
["Diclofenac","E-Selectin",0,0,1,0,"SELE","8691982",1996,"Diclofenac inhibits endothelial cell adhesion molecule expression induced with lipopolysaccharide.","8691982","Diclofenac","E-Selectin"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L324,L324)","v":"Diclofenac"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M324,M324)","v":"Receptors, Thromboxane A2, Prostaglandin H2"},0,0,1,1,"TBXA2R",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K324,K324)","v":"20117851"},2010,"Dual COXIB/TP antagonists: a possible new twist in NSAID pharmacology and cardiovascular risk.","20117851","Diclofenac","Receptors, Thromboxane A2, Prostaglandin H2"]
["Diclofenac","Receptors, Thromboxane A2, Prostaglandin H2",0,0,1,0,"TBXA2R","22865828",2012,"Designing multitarget anti-inflammatory agents: chemical modulation of the lumiracoxib structure toward dual thromboxane antagonists-COX-2 inhibitors.","22865828","Diclofenac","Receptors, Thromboxane A2, Prostaglandin H2"]
["Diclofenac","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","12028443",2002,"Inhibiting albumin glycation in vivo ameliorates glomerular overexpression of TGF-beta1.","12028443","Diclofenac","Transforming Growth Factor beta1"]
["Diclofenac","Tissue Inhibitor of Metalloproteinase-1",0,0,1,0,"TIMP1","10807502",2000,"A major metabolite of aceclofenac, 4'-hydroxy aceclofenac, suppresses the production of interstitial pro-collagenase/proMMP-1 and pro-stromelysin-1/proMMP-3 by human rheumatoid synovial cells.","10807502","Diclofenac","Tissue Inhibitor of Metalloproteinase-1"]
["Diclofenac","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","8691982",1996,"Diclofenac inhibits endothelial cell adhesion molecule expression induced with lipopolysaccharide.","8691982","Diclofenac","Vascular Cell Adhesion Molecule-1"]
["Diethylhexyl Phthalate","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","3257172",1988,"Suppression of EGF binding in rat liver by the hypolipidemic peroxisome proliferators, 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio-(N-beta-hydroxyethyl)ac etamide and di(2-ethylhexyl)phthalate.","3257172","Diethylhexyl Phthalate","Receptor, Epidermal Growth Factor"]
["Diethylhexyl Phthalate","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","3257172",1988,"Suppression of EGF binding in rat liver by the hypolipidemic peroxisome proliferators, 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio-(N-beta-hydroxyethyl)ac etamide and di(2-ethylhexyl)phthalate.","3257172","Diethylhexyl Phthalate","Receptor, Epidermal Growth Factor"]
["Diethylhexyl Phthalate","Matrix Metalloproteinase 9",1,0,1,1,"MMP9","22321834",2012,"Mono-(2-ethylhexyl) phthalate (MEHP) promotes invasion and migration of human testicular embryonal carcinoma cells.","22321834","Diethylhexyl Phthalate","Matrix Metalloproteinase 9"]
["Diethylhexyl Phthalate","Matrix Metalloproteinase 9",1,0,1,1,"MMP9","22321834",2012,"Mono-(2-ethylhexyl) phthalate (MEHP) promotes invasion and migration of human testicular embryonal carcinoma cells.","22321834","Diethylhexyl Phthalate","Matrix Metalloproteinase 9"]
["Diethylhexyl Phthalate","E-Selectin",1,0,1,1,"SELE","22002965",2012,"DEHP and its active metabolites: leaching from different tubing types, impact on proinflammatory cytokines and adhesion molecule expression. Is there a subsumable context?","22002965","Diethylhexyl Phthalate","E-Selectin"]
["Diethylhexyl Phthalate","E-Selectin",1,0,1,1,"SELE","22002965",2012,"DEHP and its active metabolites: leaching from different tubing types, impact on proinflammatory cytokines and adhesion molecule expression. Is there a subsumable context?","22002965","Diethylhexyl Phthalate","E-Selectin"]
["Diethylhexyl Phthalate","Transforming Growth Factor beta1",1,0,1,1,"TGFB1","18686198",2008,"Di(2-ethylhexyl) phthalate (DEHP) increases transforming growth factor-beta1 expression in fetal mouse genital tubercles.","18686198","Diethylhexyl Phthalate","Transforming Growth Factor beta1"]
["Diethylhexyl Phthalate","Transforming Growth Factor beta1",1,0,1,1,"TGFB1","23193663",2012,"[Di-2-ethylhexyl phthalate and its metabolite single-ethylhexyl phthalate affect TGF-beta 1 expression and telomerase activity in the testis of young male rats].","23193663","Diethylhexyl Phthalate","Transforming Growth Factor beta1"]
["Diethylhexyl Phthalate","Transforming Growth Factor beta1",1,0,1,1,"TGFB1","16809437",2006,"Testicular gene expression profiling following prepubertal rat mono-(2-ethylhexyl) phthalate exposure suggests a common initial genetic response at fetal and prepubertal ages.","16809437","Diethylhexyl Phthalate","Transforming Growth Factor beta1"]
["Diethylhexyl Phthalate","Transforming Growth Factor beta1",1,0,1,1,"TGFB1","16809437",2006,"Testicular gene expression profiling following prepubertal rat mono-(2-ethylhexyl) phthalate exposure suggests a common initial genetic response at fetal and prepubertal ages.","16809437","Diethylhexyl Phthalate","Transforming Growth Factor beta1"]
["Diethylhexyl Phthalate","Transforming Growth Factor beta1",1,0,1,1,"TGFB1","23193663",2012,"[Di-2-ethylhexyl phthalate and its metabolite single-ethylhexyl phthalate affect TGF-beta 1 expression and telomerase activity in the testis of young male rats].","23193663","Diethylhexyl Phthalate","Transforming Growth Factor beta1"]
["Diethylhexyl Phthalate","Transforming Growth Factor beta1",1,0,1,1,"TGFB1","18686198",2008,"Di(2-ethylhexyl) phthalate (DEHP) increases transforming growth factor-beta1 expression in fetal mouse genital tubercles.","18686198","Diethylhexyl Phthalate","Transforming Growth Factor beta1"]
["Diethylhexyl Phthalate","Vascular Cell Adhesion Molecule-1",1,0,1,1,"VCAM1","22002965",2012,"DEHP and its active metabolites: leaching from different tubing types, impact on proinflammatory cytokines and adhesion molecule expression. Is there a subsumable context?","22002965","Diethylhexyl Phthalate","Vascular Cell Adhesion Molecule-1"]
["Diethylhexyl Phthalate","Vascular Cell Adhesion Molecule-1",1,0,1,1,"VCAM1","22002965",2012,"DEHP and its active metabolites: leaching from different tubing types, impact on proinflammatory cytokines and adhesion molecule expression. Is there a subsumable context?","22002965","Diethylhexyl Phthalate","Vascular Cell Adhesion Molecule-1"]
["Diethylstilbestrol","Macrophage Colony-Stimulating Factor",1,1,1,0,"CSF1","9769374",1998,"Expression of cytokines enhancing the osteoclast activity, and parathyroid hormone-related protein in prostatic cancers before and after endocrine therapy: an immunohistochemical study.","9769374","Diethylstilbestrol","Macrophage Colony-Stimulating Factor"]
["Diethylstilbestrol","Receptor, Epidermal Growth Factor",1,1,1,1,"EGFR","12371671",2002,"Characterization of uterine leiomyomas in CD-1 mice following developmental exposure to diethylstilbestrol (DES).","12371671","Diethylstilbestrol","Receptor, Epidermal Growth Factor"]
["Diethylstilbestrol","Receptor, Epidermal Growth Factor",1,1,1,0,"EGFR","14647453",2004,"Estrogen-independent activation of erbBs signaling and estrogen receptor alpha in the mouse vagina exposed neonatally to diethylstilbestrol.","14647453","Diethylstilbestrol","Receptor, Epidermal Growth Factor"]
["Diethylstilbestrol","Receptor, Epidermal Growth Factor",1,1,1,0,"EGFR","11524234",2001,"Effect of diethylstilbestrol on cell proliferation and expression of epidermal growth factor in the developing female rat reproductive tract.","11524234","Diethylstilbestrol","Receptor, Epidermal Growth Factor"]
["Diethylstilbestrol","Receptor, Epidermal Growth Factor",1,1,1,1,"EGFR","12840195",2003,"Dietary diethylstilbestrol but not genistein adversely affects rat testicular development.","12840195","Diethylstilbestrol","Receptor, Epidermal Growth Factor"]
["Diethylstilbestrol","Receptor, Epidermal Growth Factor",1,1,1,0,"EGFR","3676321",1987,"Expression of the avian c-erb B (EGF receptor) protooncogene during estrogen-promoted oviduct growth.","3676321","Diethylstilbestrol","Receptor, Epidermal Growth Factor"]
["Diethylstilbestrol","Receptor, Epidermal Growth Factor",1,1,1,1,"EGFR","8761417",1996,"Involvement of transforming growth factor-alpha and its receptor in a model of DES-induced renal carcinogenesis in the Syrian hamster.","8761417","Diethylstilbestrol","Receptor, Epidermal Growth Factor"]
["Diethylstilbestrol","Receptor, Epidermal Growth Factor",1,1,1,0,"EGFR","8372093",1993,"Epidermal growth factor receptor levels in reproductive organs of female mice exposed neonatally to diethylstilbestrol.","8372093","Diethylstilbestrol","Receptor, Epidermal Growth Factor"]
["Diethylstilbestrol","Matrix Metalloproteinase 9",1,1,1,0,"MMP9","20675286",2010,"Melatonin modulates the effects of diethylstilbestrol (DES) on the anterior pituitary of the female Wistar rat.","20675286","Diethylstilbestrol","Matrix Metalloproteinase 9"]
["Diethylstilbestrol","Transforming Growth Factor beta1",1,1,1,0,"TGFB1","12960047",2003,"Autocrine/paracrine action of pituitary vasoactive intestinal peptide on lactotroph hyperplasia induced by estrogen.","12960047","Diethylstilbestrol","Transforming Growth Factor beta1"]
["Dimethoate","Matrix Metalloproteinase 9",1,1,1,1,"MMP9","21417632",2011,"Escin attenuates cerebral edema induced by acute omethoate poisoning.","21417632","Dimethoate","Matrix Metalloproteinase 9"]
["Dimethylformamide","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","2206777",1990,"Modulation of EGF receptor expression by differentiating agents in human colon carcinoma cell lines.","2206777","Dimethylformamide","Receptor, Epidermal Growth Factor"]
["Dimethylformamide","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","1537633",1992,"Response of FR3T3 cells transformed by Ha-ras oncogene and epidermal growth factor gene to differentiation induction by N,N-dimethylformamide.","1537633","Dimethylformamide","Receptor, Epidermal Growth Factor"]
["Dimethylformamide","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","2981156",1985,"Elevated growth factor levels in transformed mouse embryo cells treated with N,N-dimethylformamide.","2981156","Dimethylformamide","Receptor, Epidermal Growth Factor"]
["Dimethylformamide","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","2998599",1985,"Changes in receptor occupancy and growth factor responsiveness induced by treatment of a transformed mouse embryo cell line with N,N-dimethylformamide.","2998599","Dimethylformamide","Receptor, Epidermal Growth Factor"]
["Dimethylformamide","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","8344991",1993,"Modulation of the immunophenotype of ovarian cancer cells by N,N-dimethylformamide and transforming growth factor-beta 1.","8344991","Dimethylformamide","Receptor, Epidermal Growth Factor"]
["Dimethylformamide","Receptors, Urokinase Plasminogen Activator",1,0,1,0,"PLAUR","2835992",1988,"Modulation of the urokinase receptor in human colon cell lines by N,N-dimethylformamide.","2835992","Dimethylformamide","Receptors, Urokinase Plasminogen Activator"]
["Dimethylnitrosamine","Chemokine CCL2",0,0,1,0,"CCL2","15762874",2005,"4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone, a component of tobacco smoke, modulates mediator release from human bronchial and alveolar epithelial cells.","15762874","Dimethylnitrosamine","Chemokine CCL2"]
["Dimethylnitrosamine","NF-E2-Related Factor 2",0,0,1,1,"NFE2L2","18006204",2008,"Curcumin attenuates dimethylnitrosamine-induced liver injury in rats through Nrf2-mediated induction of heme oxygenase-1.","18006204","Dimethylnitrosamine","NF-E2-Related Factor 2"]
["Dimethylnitrosamine","NF-E2-Related Factor 2",0,0,1,1,"NFE2L2","23485615",2013,"Platycodi Radix attenuates dimethylnitrosamine-induced liver fibrosis in rats by inducing Nrf2-mediated antioxidant enzymes.","23485615","Dimethylnitrosamine","NF-E2-Related Factor 2"]
["Dimethylnitrosamine","NF-E2-Related Factor 2",0,0,1,1,"NFE2L2","20934476",2011,"Anthocyanins from purple sweet potato attenuate dimethylnitrosamine-induced liver injury in rats by inducing Nrf2-mediated antioxidant enzymes and reducing COX-2 and iNOS expression.","20934476","Dimethylnitrosamine","NF-E2-Related Factor 2"]
["Dimethylnitrosamine","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","15723089",2005,"Inhibition of TGF-beta signaling by an ALK5 inhibitor protects rats from dimethylnitrosamine-induced liver fibrosis.","15723089","Dimethylnitrosamine","Plasminogen Activator Inhibitor 1"]
["Dimethylnitrosamine","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","16604421",2006,"Anti-fibrotic effects of thalidomide on hepatic stellate cells and dimethylnitrosamine-intoxicated rats.","16604421","Dimethylnitrosamine","Transforming Growth Factor beta1"]
["Dimethylnitrosamine","Transforming Growth Factor beta1",0,0,1,1,"TGFB1","20607498",2010,"Resveratrol inhibits dimethylnitrosamine-induced hepatic fibrosis in rats.","20607498","Dimethylnitrosamine","Transforming Growth Factor beta1"]
["Dimethylnitrosamine","Transforming Growth Factor beta1",0,0,1,1,"TGFB1","23411180",2013,"Pterostilbene inhibits dimethylnitrosamine-induced liver fibrosis in rats.","23411180","Dimethylnitrosamine","Transforming Growth Factor beta1"]
["Dimethylnitrosamine","Transforming Growth Factor beta1",0,0,1,1,"TGFB1","23291610",2013,"Phyto-power dietary supplement potently inhibits dimethylnitrosamine-induced liver fibrosis in rats.","23291610","Dimethylnitrosamine","Transforming Growth Factor beta1"]
["Dimethylnitrosamine","Transforming Growth Factor beta1",0,0,1,1,"TGFB1","15864749",2005,"Antifibrotic effects of Salvia miltiorrhiza on dimethylnitrosamine-intoxicated rats.","15864749","Dimethylnitrosamine","Transforming Growth Factor beta1"]
["Dimethylnitrosamine","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","16979622",2006,"Increased iron deposition in rat liver fibrosis induced by a high-dose injection of dimethylnitrosamine.","16979622","Dimethylnitrosamine","Transforming Growth Factor beta1"]
["Dimethylnitrosamine","Transforming Growth Factor beta1",0,0,1,1,"TGFB1","11484906",2001,"2-(Allylthio)pyrazine, a cancer chemopreventive agent, inhibits liver fibrosis induced by dimethylnitrosamine in rats: role of inhibition of transforming growth factor-beta1 expression.","11484906","Dimethylnitrosamine","Transforming Growth Factor beta1"]
["Dimethylnitrosamine","Transforming Growth Factor beta1",0,0,1,1,"TGFB1","23435910",2013,"Effect of sinapic acid against dimethylnitrosamine-induced hepatic fibrosis in rats.","23435910","Dimethylnitrosamine","Transforming Growth Factor beta1"]
["Dimethylnitrosamine","Transforming Growth Factor beta1",0,0,1,1,"TGFB1","20054803",2010,"Comparison of the tumorigenic potential of liver and kidney tumors induced by N-nitrosodimethylamine.","20054803","Dimethylnitrosamine","Transforming Growth Factor beta1"]
["Dimethylnitrosamine","Transforming Growth Factor beta1",0,0,1,1,"TGFB1","20208363",2010,"Protective effects of Cinnamomum cassia Blume in the fibrogenesis of activated HSC-T6 cells and dimethylnitrosamine-induced acute liver injury in SD rats.","20208363","Dimethylnitrosamine","Transforming Growth Factor beta1"]
["Dimethylnitrosamine","Tissue Inhibitor of Metalloproteinase-1",0,0,1,1,"TIMP1","15067225",2004,"Increases in fibrosis-related gene transcripts in livers of dimethylnitrosamine-intoxicated rats.","15067225","Dimethylnitrosamine","Tissue Inhibitor of Metalloproteinase-1"]
["Dimethylnitrosamine","Tissue Inhibitor of Metalloproteinase-1",0,0,1,1,"TIMP1","23485615",2013,"Platycodi Radix attenuates dimethylnitrosamine-induced liver fibrosis in rats by inducing Nrf2-mediated antioxidant enzymes.","23485615","Dimethylnitrosamine","Tissue Inhibitor of Metalloproteinase-1"]
["Dimethylnitrosamine","Tissue Inhibitor of Metalloproteinase-1",0,0,1,1,"TIMP1","20208363",2010,"Protective effects of Cinnamomum cassia Blume in the fibrogenesis of activated HSC-T6 cells and dimethylnitrosamine-induced acute liver injury in SD rats.","20208363","Dimethylnitrosamine","Tissue Inhibitor of Metalloproteinase-1"]
["Dimethylnitrosamine","Tissue Inhibitor of Metalloproteinase-1",0,0,1,1,"TIMP1","15864749",2005,"Antifibrotic effects of Salvia miltiorrhiza on dimethylnitrosamine-intoxicated rats.","15864749","Dimethylnitrosamine","Tissue Inhibitor of Metalloproteinase-1"]
["Dimethylnitrosamine","Tissue Inhibitor of Metalloproteinase-1",0,0,1,1,"TIMP1","16603200",2006,"Effects of bicyclol on dimethylnitrosamine-induced liver fibrosis in mice and its mechanism of action.","16603200","Dimethylnitrosamine","Tissue Inhibitor of Metalloproteinase-1"]
["Dimethylnitrosamine","Tissue Inhibitor of Metalloproteinase-1",0,0,1,1,"TIMP1","21333722",2011,"Hepatoprotective effects of Yi Guan Jian, an herbal medicine, in rats with dimethylnitrosamine-induced liver fibrosis.","21333722","Dimethylnitrosamine","Tissue Inhibitor of Metalloproteinase-1"]
["Diphenylamine","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","20580136",2010,"Synthesis and biological evaluation of novel 2,4'-bis substituted diphenylamines as anticancer agents and potential epidermal growth factor receptor tyrosine kinase inhibitors.","20580136","Diphenylamine","Receptor, Epidermal Growth Factor"]
["Diphenylamine","Receptor, Epidermal Growth Factor",1,0,1,1,"EGFR","21881256",2011,"Novel diphenylamine 2,4'-dicarboxamide based azoles as potential epidermal growth factor receptor inhibitors: synthesis and biological activity.","21881256","Diphenylamine","Receptor, Epidermal Growth Factor"]
["Diquat","NF-E2-Related Factor 2",0,0,0,1,"NFE2L2","20826540",2011,"Hepatic response to oxidative injury in long-lived Ames dwarf mice.","20826540","Diquat","NF-E2-Related Factor 2"]
["Diquat","NF-E2-Related Factor 2",0,0,0,1,"NFE2L2","22762311",2012,"Nrf2 protects against diquat-induced liver and lung injury.","22762311","Diquat","NF-E2-Related Factor 2"]
["Diquat","NF-E2-Related Factor 2",0,0,0,0,"NFE2L2","16962985",2006,"Nrf2 regulates an adaptive response protecting against oxidative damage following diquat-mediated formation of superoxide anion.","16962985","Diquat","NF-E2-Related Factor 2"]
["Endosulfan","Plasminogen Activator Inhibitor 1",1,0,1,1,"SERPINE1","21804306",2011,"Endosulfan-induced lipid peroxidation in rat brain and its effect on t-PA and PAI-1: ameliorating effect of vitamins C and E.","21804306","Endosulfan","Plasminogen Activator Inhibitor 1"]
["Estradiol","Chemokine CCL2",1,0,1,0,"CCL2","10690908",2000,"Estradiol amplifies interleukin-1-induced monocyte chemotactic protein-1 expression by ectopic endometrial cells of women with endometriosis.","10690908","Estradiol","Chemokine CCL2"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L388,L388)","v":"Estradiol"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M388,M388)","v":"Chemokine CCL2"},1,0,1,0,"CCL2",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K388,K388)","v":"20404154"},2010,"Estradiol inhibits ongoing autoimmune neuroinflammation and NFkappaB-dependent CCL2 expression in reactive astrocytes.","20404154","Estradiol","Chemokine CCL2"]
["Estradiol","Chemokine CCL2",1,0,1,0,"CCL2","17389368",2007,"Timing of estrogen therapy after ovariectomy dictates the efficacy of its neuroprotective and antiinflammatory actions.","17389368","Estradiol","Chemokine CCL2"]
["Estradiol","Chemokine CCL2",1,0,1,0,"CCL2","15501247",2004,"Tissue-specific effect of estradiol on endothelial cell-dependent lymphocyte recruitment.","15501247","Estradiol","Chemokine CCL2"]
["Estradiol","Chemokine CCL2",1,0,1,0,"CCL2","19012101",2008,"Effects of estradiol and progestogens on tumor-necrosis factor-alpha-induced changes of biochemical markers for breast cancer growth and metastasis.","19012101","Estradiol","Chemokine CCL2"]
["Estradiol","Chemokine CCL2",1,0,1,0,"CCL2","16895975",2006,"Effects of 17beta-estradiol and flutamide on inflammatory response and distant organ damage following trauma-hemorrhage in metestrus females.","16895975","Estradiol","Chemokine CCL2"]
["Estradiol","Chemokine CCL2",1,0,1,0,"CCL2","17351072",2007,"Estrogen-TNF interactions and vascular inflammation.","17351072","Estradiol","Chemokine CCL2"]
["Estradiol","Chemokine CCL2",1,0,1,0,"CCL2","23841471",2013,"Differential effects of the estrogen receptor agonist estradiol on toxicity induced by enzymatically-derived or autoxidation-derived oxysterols in human ARPE-19 cells.","23841471","Estradiol","Chemokine CCL2"]
["Estradiol","Chemokine CCL2",1,0,1,0,"CCL2","15353495",2004,"Estrogen modulates inflammatory mediator expression and neutrophil chemotaxis in injured arteries.","15353495","Estradiol","Chemokine CCL2"]
["Estradiol","Chemokine CCL2",1,0,1,0,"CCL2","10871649",2000,"Ovarian hormones modulate monocyte chemotactic protein-1 expression in endometrial cells of women with endometriosis.","10871649","Estradiol","Chemokine CCL2"]
["Estradiol","Chemokine CCL2",1,0,1,0,"CCL2","11449089",2001,"Estradiol regulates monocyte chemotactic protein-1 in human coronary artery smooth muscle cells: a mechanism for its antiatherogenic effect.","11449089","Estradiol","Chemokine CCL2"]
["Estradiol","Chemokine CCL2",1,0,1,0,"CCL2","20138621",2010,"Estrogen attenuates vascular remodeling in Lp(a) transgenic mice.","20138621","Estradiol","Chemokine CCL2"]
["Estradiol","Chemokine CCL2",1,0,1,0,"CCL2","17237237",2007,"Estrogen modulates TNF-alpha-induced inflammatory responses in rat aortic smooth muscle cells through estrogen receptor-beta activation.","17237237","Estradiol","Chemokine CCL2"]
["Estradiol","Chemokine CCL2",1,0,1,0,"CCL2","17373633",2007,"Site-specific effect of estradiol on gene expression in the adipose tissue of ob/ob mice.","17373633","Estradiol","Chemokine CCL2"]
["Estradiol","Chemokine CCL2",1,0,1,0,"CCL2","11641238",2001,"17beta-estradiol inhibition of NADPH oxidase expression in human endothelial cells.","11641238","Estradiol","Chemokine CCL2"]
["Estradiol","Chemokine CCL2",1,0,1,0,"CCL2","18347511",2008,"Associations of circulating adiponectin with estradiol and monocyte chemotactic protein-1 in postmenopausal women.","18347511","Estradiol","Chemokine CCL2"]
["Estradiol","Chemokine CCL2",1,0,1,0,"CCL2","10729783",2000,"Mediation of the immunomodulatory effect of beta-estradiol on inflammatory responses by inhibition of recruitment and activation of inflammatory cells and their gene expression of TNF-alpha and IFN-gamma.","10729783","Estradiol","Chemokine CCL2"]
["Estradiol","Chemokine CCL2",1,0,1,0,"CCL2","11872210",2002,"Estradiol down-regulates MCP-1 expression in human coronary artery endothelial cells.","11872210","Estradiol","Chemokine CCL2"]
["Estradiol","Chemokine CCL2",1,0,1,0,"CCL2","11669471",2001,"Cytokine and nitric oxide release by J774A.1 macrophages is not regulated by estradiol.","11669471","Estradiol","Chemokine CCL2"]
["Estradiol","Chemokine CCL2",1,0,1,0,"CCL2","15142882",2004,"17beta-estradiol (E2) modulates cytokine and chemokine expression in human monocyte-derived dendritic cells.","15142882","Estradiol","Chemokine CCL2"]
["Estradiol","Chemokine CCL2",1,0,1,0,"CCL2","20538789",2010,"17beta-estradiol down-regulates lipopolysaccharide-induced MCP-1 production and cell migration in vascular smooth muscle cells.","20538789","Estradiol","Chemokine CCL2"]
["Estradiol","Chemokine CCL2",1,0,1,0,"CCL2","12218988",2002,"17 beta-estradiol attenuates intimal hyperplasia and macrophage accumulation with a reduction in monocyte chemoattractant protein 1 expression in a vein graft model.","12218988","Estradiol","Chemokine CCL2"]
["Estradiol","Chemokine CCL2",1,0,1,0,"CCL2","12204776",2002,"17Beta-estradiol inhibits the adhesion of leukocytes in TNF-alpha stimulated human endothelial cells by blocking IL-8 and MCP-1 secretion, but not its transcription.","12204776","Estradiol","Chemokine CCL2"]
["Estradiol","Chemokine CCL2",1,0,1,0,"CCL2","10377035",1999,"Regulation of monocyte chemotactic protein-1 expression in human endometrial stromal cells by estrogen and progesterone.","10377035","Estradiol","Chemokine CCL2"]
["Estradiol","Chemokine CCL2",1,0,1,0,"CCL2","12787135",2003,"17Beta-estradiol inhibits MCP-1 production in human keratinocytes.","12787135","Estradiol","Chemokine CCL2"]
["Estradiol","Chemokine CCL2",1,0,1,0,"CCL2","17006379",2006,"Estrogen and raloxifene inhibit the monocytic chemoattractant protein-1-induced migration of human monocytic cells via nongenomic estrogen receptor alpha.","17006379","Estradiol","Chemokine CCL2"]
["Estradiol","Chemokine CCL2",1,0,1,0,"CCL2","12355436",2002,"Negative regulation of monocyte chemoattractant protein-1 gene expression by a mouse estrogen-enhanced transcript.","12355436","Estradiol","Chemokine CCL2"]
["Estradiol","Chemokine CCL2",1,0,1,0,"CCL2","18511016",2008,"Metabolic syndrome in postmenopausal women: the influence of oral or transdermal estradiol on inflammation and coagulation markers.","18511016","Estradiol","Chemokine CCL2"]
["Estradiol","Chemokine CCL2",1,0,1,0,"CCL2","22381103",2012,"Effects of 17?-estradiol on the release of monocyte chemotactic protein-1 and MAPK activity in monocytes stimulated with peritoneal fluid from endometriosis patients.","22381103","Estradiol","Chemokine CCL2"]
["Estradiol","Chemokine CCL2",1,0,1,0,"CCL2","15194470",2004,"Estrogen-mediated protection against HIV Tat protein-induced inflammatory pathways in human vascular endothelial cells.","15194470","Estradiol","Chemokine CCL2"]
["Estradiol","Chemokine CCL2",1,0,1,0,"CCL2","16359995",2005,"Effect of monocyte chemoattractant protein-1 and estradiol on the secretion of vascular endothelial growth factor in endometrial stromal cells in vitro.","16359995","Estradiol","Chemokine CCL2"]
["Estradiol","Chemokine CCL2",1,0,1,0,"CCL2","16543969",2006,"The estrogen metabolite 17beta-dihydroequilenin counteracts interleukin-1alpha induced expression of inflammatory mediators in human endothelial cells in vitro via NF-kappaB pathway.","16543969","Estradiol","Chemokine CCL2"]
["Estradiol","Chemokine CCL2",1,0,1,0,"CCL2","20701669",2010,"Differential regulation of chemokine expression by estrogen in human periodontal ligament cells.","20701669","Estradiol","Chemokine CCL2"]
["Estradiol","Chemokine CCL2",1,0,1,0,"CCL2","9763529",1998,"Estradiol suppresses MCP-1 expression In vivo : implications for atherosclerosis.","9763529","Estradiol","Chemokine CCL2"]
["Estradiol","Chemokine CCL2",1,0,1,0,"CCL2","7836768",1995,"Estrogen modulation of JE/monocyte chemoattractant protein-1 mRNA expression in murine macrophages.","7836768","Estradiol","Chemokine CCL2"]
["Estradiol","Chemokine CCL2",1,0,1,0,"CCL2","9627299",1998,"Expression and hormonal regulation of monocyte chemotactic protein-1 in myometrium and leiomyomata.","9627299","Estradiol","Chemokine CCL2"]
["Estradiol","Chemokine CCL2",1,0,1,0,"CCL2","8781708",1996,"Physiological concentration of 17 beta-estradiol inhibits chemotaxis of human monocytes in response to monocyte chemotactic protein 1.","8781708","Estradiol","Chemokine CCL2"]
["Estradiol","Chemokine CCL2",1,0,1,0,"CCL2","8609426",1996,"Estrogen suppression of connective tissue deposition in a murine model of peritoneal adhesion formation.","8609426","Estradiol","Chemokine CCL2"]
["Estradiol","Chemokine CCL2",1,0,1,0,"CCL2","8613705",1996,"Estrogen regulation of JE/MCP-1 mRNA expression in fibroblasts.","8613705","Estradiol","Chemokine CCL2"]
["Estradiol","Antigens, CD40",1,0,1,0,"CD40","20037646",2009,"17beta-estradiol enhances the response of plasmacytoid dendritic cell to CpG.","20037646","Estradiol","Antigens, CD40"]
["Estradiol","Antigens, CD40",1,0,1,0,"CD40","21538324",2011,"17?-estradiol induces CD40 expression in dendritic cells via MAPK signaling pathways in a minichromosome maintenance protein 6-dependent manner.","21538324","Estradiol","Antigens, CD40"]
["Estradiol","Antigens, CD40",1,0,1,0,"CD40","16797503",2006,"Estradiol blocks the induction of CD40 and CD40L expression on endothelial cells and prevents neutrophil adhesion: an ERalpha-mediated pathway.","16797503","Estradiol","Antigens, CD40"]
["Estradiol","Antigens, CD40",1,0,1,0,"CD40","22043860",2012,"Effect of oestradiol and pathogen-associated molecular patterns on class II-mediated antigen presentation and immunomodulatory molecule expression in the mouse female reproductive tract.","22043860","Estradiol","Antigens, CD40"]
["Estradiol","Antigens, CD40",1,0,1,0,"CD40","15191709",2004,"Estrogen affects the differentiation and function of splenic monocyte-derived dendritic cells from normal rats.","15191709","Estradiol","Antigens, CD40"]
["Estradiol","Antigens, CD40",1,0,1,0,"CD40","22960279",2012,"17?-Estradiol enhances response of mice spleen B cells elicited by TLR9 agonist.","22960279","Estradiol","Antigens, CD40"]
["Estradiol","Antigens, CD40",1,0,1,0,"CD40","18584416",2008,"Therapeutic dosages of oral or transdermal estradiol did not modify sCD40L levels in postmenopausal women.","18584416","Estradiol","Antigens, CD40"]
["Estradiol","Antigens, CD40",1,0,1,0,"CD40","15142882",2004,"17beta-estradiol (E2) modulates cytokine and chemokine expression in human monocyte-derived dendritic cells.","15142882","Estradiol","Antigens, CD40"]
["Estradiol","Antigens, CD40",1,0,1,0,"CD40","18389442",2008,"Estrogen modulates bone marrow-derived DCs in SLE murine model-(NZB x NZW) F1 female mice.","18389442","Estradiol","Antigens, CD40"]
["Estradiol","Antigens, CD40",1,0,1,0,"CD40","11764210",2001,"Estrogen increases CD40 ligand expression in T cells from women with systemic lupus erythematosus.","11764210","Estradiol","Antigens, CD40"]
["Estradiol","Antigens, CD40",1,0,1,0,"CD40","15964915",2005,"Estrogenic regulation of tissue factor and tissue factor pathway inhibitor in platelets.","15964915","Estradiol","Antigens, CD40"]
["Estradiol","Antigens, CD40",1,0,1,0,"CD40","20551107",2010,"Raloxifene modulates estrogen-mediated B cell autoreactivity in NZB/W F1 mice.","20551107","Estradiol","Antigens, CD40"]
["Estradiol","Collagen Type III",1,0,1,0,"COL3A1","12669156",2003,"Effects of ovariectomy and hormone replacement on collagen and blood vessels of the urethral submucosa of rats.","12669156","Estradiol","Collagen Type III"]
["Estradiol","Collagen Type III",1,0,1,0,"COL3A1","20073985",2010,"Effect of selective estrogen receptor modulator/raloxifene analogue on proliferation and collagen metabolism of tendon fibroblast.","20073985","Estradiol","Collagen Type III"]
["Estradiol","Collagen Type III",1,0,1,0,"COL3A1","15521940",2004,"Effects of ovariectomy and hormone replacement on submucosal collagen and blood vessels of the anal canal of rats.","15521940","Estradiol","Collagen Type III"]
["Estradiol","Collagen Type III",1,0,1,0,"COL3A1","18794456",2008,"Induction of collagen by estradiol: difference between sun-protected and photodamaged human skin in vivo.","18794456","Estradiol","Collagen Type III"]
["Estradiol","Collagen Type III",1,0,1,0,"COL3A1","20825049",2010,"[Collagen type III biosynthesis by cultured pubocervical fascia fibroblasts surrounding mono and multifilament polypropylene mesh after estrogens and tamoxifen treatment].","20825049","Estradiol","Collagen Type III"]
["Estradiol","Collagen Type III",1,0,1,0,"COL3A1","17010202",2006,"Hernia fibroblasts lack beta-estradiol-induced alterations of collagen gene expression.","17010202","Estradiol","Collagen Type III"]
["Estradiol","Collagen Type III",1,0,1,0,"COL3A1","17876488",2008,"Combined estrogen and ghrelin administration restores number of blood vessels and collagen type I/III ratio in the urethral and anal canal submucosa of old ovariectomized rats.","17876488","Estradiol","Collagen Type III"]
["Estradiol","Collagen Type III",1,0,1,0,"COL3A1","18451633",2008,"Local delivery of 17-beta-estradiol modulates collagen content in coronary porcine arteries after PTCA and stent implantation.","18451633","Estradiol","Collagen Type III"]
["Estradiol","Macrophage Colony-Stimulating Factor",1,0,1,0,"CSF1","14636471",2003,"[The effects of 17 beta-estradiol on the expression of osteoprotegerin, the ligand of osteoprotegerin and related cytokines in osteosarcoma MG63 cells].","14636471","Estradiol","Macrophage Colony-Stimulating Factor"]
["Estradiol","Macrophage Colony-Stimulating Factor",1,0,1,0,"CSF1","12126567",2002,"[Effects of macrophage colony-stimulating factor on production of estradiol and progesterone by human luteinized granulosa cells in vitro and detection of macrophage colony-stimulating factor receptor on human luteinized granulosa cells].","12126567","Estradiol","Macrophage Colony-Stimulating Factor"]
["Estradiol","Macrophage Colony-Stimulating Factor",1,0,1,0,"CSF1","10792003",2000,"M-CSF neutralization and egr-1 deficiency prevent ovariectomy-induced bone loss.","10792003","Estradiol","Macrophage Colony-Stimulating Factor"]
["Estradiol","Macrophage Colony-Stimulating Factor",1,0,1,0,"CSF1","12065288",2002,"Modulatory effects of estrogen in two murine models of experimental colitis.","12065288","Estradiol","Macrophage Colony-Stimulating Factor"]
["Estradiol","Macrophage Colony-Stimulating Factor",1,0,1,0,"CSF1","17768586",2008,"Estradiol rapidly inhibits osteoclastogenesis and RANKL expression in bone marrow cultures in postmenopausal women: a pilot study.","17768586","Estradiol","Macrophage Colony-Stimulating Factor"]
["Estradiol","Macrophage Colony-Stimulating Factor",1,0,1,0,"CSF1","14680610",2003,"[Effect of estradiol and progesterone on production of macrophage colony-stimulating factor by human granulosa cells in vitro].","14680610","Estradiol","Macrophage Colony-Stimulating Factor"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L452,L452)","v":"Estradiol"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M452,M452)","v":"Macrophage Colony-Stimulating Factor"},1,0,1,0,"CSF1",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K452,K452)","v":"17420779"},2007,"Differential effects of selective oestrogen receptor modulators (SERMs) tamoxifen, ospemifene and raloxifene on human osteoclasts in vitro.","17420779","Estradiol","Macrophage Colony-Stimulating Factor"]
["Estradiol","Macrophage Colony-Stimulating Factor",1,0,1,0,"CSF1","16294275",2005,"Estrogen and testosterone use different cellular pathways to inhibit osteoclastogenesis and bone resorption.","16294275","Estradiol","Macrophage Colony-Stimulating Factor"]
["Estradiol","Macrophage Colony-Stimulating Factor",1,0,1,0,"CSF1","17880962",2008,"Involvement of macrophage colony-stimulating factor (M-CSF) in the function of follicular granulosa cells.","17880962","Estradiol","Macrophage Colony-Stimulating Factor"]
["Estradiol","Macrophage Colony-Stimulating Factor",1,0,1,0,"CSF1","9491785",1998,"Inhibition of bone resorption by 17beta-estradiol in human bone marrow cultures.","9491785","Estradiol","Macrophage Colony-Stimulating Factor"]
["Estradiol","Chemokine CXCL10",1,0,1,0,"CXCL10","12603854",2003,"17beta-estradiol inhibits the production of interferon-induced protein of 10 kDa by human keratinocytes.","12603854","Estradiol","Chemokine CXCL10"]
["Estradiol","Chemokine CXCL10",1,0,1,0,"CXCL10","15557169",2004,"Recruitment of uterine NK cells: induction of CXC chemokine ligands 10 and 11 in human endometrium by estradiol and progesterone.","15557169","Estradiol","Chemokine CXCL10"]
["Estradiol","Chemokine CXCL10",1,0,1,0,"CXCL10","19756997",2010,"Suppressive effect on MDC and IP-10 expression in monocytes by endocrine disruptor chemicals.","19756997","Estradiol","Chemokine CXCL10"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","15860267",2005,"Reversal of tamoxifen resistant breast cancer by low dose estrogen therapy.","15860267","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","20549698",2011,"p53 status influences response to tamoxifen but not to fulvestrant in breast cancer cell lines.","20549698","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","15778002",2005,"Dynamic profiling of estrogen receptor and epidermal growth factor signaling in the uteri of genistein- and estrogen-treated rats.","15778002","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","20551055",2010,"Nuclear alternate estrogen receptor GPR30 mediates 17beta-estradiol-induced gene expression and migration in breast cancer-associated fibroblasts.","20551055","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","15802018",2005,"Resveratrol and estradiol exert disparate effects on cell migration, cell surface actin structures, and focal adhesion assembly in MDA-MB-231 human breast cancer cells.","15802018","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","20425756",2010,"Flaxseed oil reduces the growth of human breast tumors (MCF-7) at high levels of circulating estrogen.","20425756","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","18799753",2009,"GPR30 does not mediate estrogenic responses in reproductive organs in mice.","18799753","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","15166495",2003,"17 beta -estradiol-mediated vessel assembly and stabilization in tumor angiogenesis requires TGF beta and EGFR crosstalk.","15166495","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","20017706",2010,"The effects of ?-zearalanol and estradiol benzoate on expression of c-myc, c-fos and epidermal growth factor receptor mRNAs in breast tissues implanted into nude mice.","20017706","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","15735034",2005,"Combined targeting of the estrogen receptor and the epidermal growth factor receptor in non-small cell lung cancer shows enhanced antiproliferative effects.","15735034","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","1551100",1992,"Differential effects of estrogen and antiestrogen on transforming growth factor gene expression in endometrial adenocarcinoma cells.","1551100","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","19556341",2009,"Rapid estradiol/ERalpha signaling enhances aromatase enzymatic activity in breast cancer cells.","19556341","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","15976008",2005,"Estrogen negatively regulates epidermal growth factor (EGF)-mediated signal transducer and activator of transcription 5 signaling in human EGF family receptor-overexpressing breast cancer cells.","15976008","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","20110355",2010,"Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2.","20110355","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","2129303",1990,"Estradiol stimulates the binding of epidermal growth factor in cultured rat granulosa cells.","2129303","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","1444236",1992,"The response of breast cancer cells to steroid and peptide growth factors.","1444236","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","2172119",1990,"Regulation of epidermal growth factor and insulin-like growth factor I receptors by estradiol and progesterone in normal and neoplastic endometrial cell cultures.","2172119","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","21639949",2011,"Endocrine resistance in breast cancer: new roles for ErbB3 and ErbB4.","21639949","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","1304800",1992,"[Cell cycle analysis of endometrial cancer cells in vitro treated with growth factor and steroid hormone].","1304800","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","1301400",1992,"An estrogen receptor positive MCF-7 clone that is resistant to antiestrogens and estradiol.","1301400","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","18409071",2009,"Activation of ErbB3, EGFR and Erk is essential for growth of human breast cancer cell lines with acquired resistance to fulvestrant.","18409071","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","14647453",2004,"Estrogen-independent activation of erbBs signaling and estrogen receptor alpha in the mouse vagina exposed neonatally to diethylstilbestrol.","14647453","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","20669046",2011,"Combined Src and ER blockade impairs human breast cancer proliferation in vitro and in vivo.","20669046","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","21396094",2011,"Fulvestrant-induced expression of ErbB3 and ErbB4 receptors sensitizes oestrogen receptor-positive breast cancer cells to heregulin ?1.","21396094","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","2064190",1991,"Steroid therapy and the endometrium: biological and clinical implications.","2064190","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","12960029",2003,"The antiepidermal growth factor receptor agent gefitinib (ZD1839/Iressa) improves antihormone response and prevents development of resistance in breast cancer in vitro.","12960029","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","18550772",2008,"Signal transducer and activator of transcription 5b, c-Src, and epidermal growth factor receptor signaling play integral roles in estrogen-stimulated proliferation of estrogen receptor-positive breast cancer cells.","18550772","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","1918178",1991,"Evidence of an EGF/TGE-alpha--independent pathway for estrogen-regulated cell proliferation.","1918178","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","1313194",1992,"The effect of 6-nitro-1,3,8-trichlorodibenzofuran as a partial estrogen in the female rat uterus.","1313194","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","19179445",2009,"Mechanisms of resistance to structurally diverse antiestrogens differ under premenopausal and postmenopausal conditions: evidence from in vitro breast cancer cell models.","19179445","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","19347870",2009,"Down-regulation of epidermal growth factor receptor induced by estrogens and phytoestrogens promotes the differentiation of U2OS human osteosarcoma cells.","19347870","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","2064983",1991,"Role of transforming growth factor-alpha (TGF-alpha) in basal and hormone-stimulated growth by estradiol, prolactin and progesterone in human and rat mammary tumor cells: studies using TGF-alpha and EGF receptor antibodies.","2064983","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","15919406",2005,"Progestin effects on epidermal growth factor receptor (EGFR) endometrial expression in normal and hyperplastic endometrium.","15919406","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","17525128",2007,"Estrogen signaling via a linear pathway involving insulin-like growth factor I receptor, matrix metalloproteinases, and epidermal growth factor receptor to activate mitogen-activated protein kinase in MCF-7 breast cancer cells.","17525128","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","18000226",2007,"Genomic and nongenomic effects of estrogen signaling in human endometrial cells: involvement of the growth factor receptor signaling downstream AKT pathway.","18000226","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","10340701",1999,"Estrogen induces cytokeratin aggregation in primary cultures of Armenian hamster hepatocytes.","10340701","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","11720134",2001,"Regulation of the expression and bioactivation of the epidermal growth factor receptor system by estradiol in pig oviduct and endometrium.","11720134","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","3000728",1986,"Induction of epidermal growth factor-related polypeptides by 17 beta-estradiol in MCF-7 human breast cancer cells.","3000728","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","18056179",2007,"Reversal of the estrogen receptor negative phenotype in breast cancer and restoration of antiestrogen response.","18056179","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","22488924",2012,"Transforming growth factor-? mediates estrogen-induced upregulation of glutamate transporter GLT-1 in rat primary astrocytes.","22488924","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","10718485",1999,"Sex hormone-induced mammary carcinogenesis in female Noble rats: expression of TGF-beta1 and its receptors, TGF-alpha, and EGF-R in mammary carcinogenesis.","10718485","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","23999432",2013,"ErbB3 downregulation enhances luminal breast tumor response to antiestrogens.","23999432","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","11463858",2001,"Hyperactivation of MAPK induces loss of ERalpha expression in breast cancer cells.","11463858","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","2224859",1990,"Characterization of a receptor-negative, hormone-nonresponsive clone derived from a T47D human breast cancer cell line kept under estrogen-free conditions.","2224859","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","11415996",2001,"Enhanced epidermal growth factor receptor signaling in MCF7 breast cancer cells after long-term culture in the presence of the pure antiestrogen ICI 182,780 (Faslodex).","11415996","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","23782942",2013,"Growth hormone potentiates 17?-estradiol-dependent breast cancer cell proliferation independently of IGF-I receptor signaling.","23782942","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","12775708",2003,"Enhanced estrogen receptor (ER) alpha, ERBB2, and MAPK signal transduction pathways operate during the adaptation of MCF-7 cells to long term estrogen deprivation.","12775708","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","12798355",2003,"Studies on the development of resistance to the pure antiestrogen Faslodex in three human breast cancer cell lines.","12798355","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","2989031",1985,"Inhibition by estradiol of binding and mitogenic effect of epidermal growth factor in primary cultures of Xenopus hepatocytes.","2989031","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","12820409",2003,"mRNA expression of the type I growth factor receptors in the human breast cancer cells MCF-7: regulation by estradiol and tamoxifen.","12820409","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","2880347",1987,"Activation of growth factor secretion in tumorigenic states of breast cancer induced by 17 beta-estradiol or v-Ha-ras oncogene.","2880347","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","24280132",2014,"Estradiol enhances CIP2A expression by the activation of p70 S6 kinase.","24280132","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","10081495",1998,"Effects of sex steroids and growth factors on invasive activity and 5'-deoxy-5-fluorouridine sensitivity in ovarian adenocarcinoma OMC-3 cells.","10081495","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","22258476",2012,"Combining the multitargeted tyrosine kinase inhibitor vandetanib with the antiestrogen fulvestrant enhances its antitumor effect in non-small cell lung cancer.","22258476","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","19171042",2009,"Autocrine regulation of cell proliferation by estrogen receptor-alpha in estrogen receptor-alpha-positive breast cancer cell lines.","19171042","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","22251451",2012,"MIBE acts as antagonist ligand of both estrogen receptor ? and GPER in breast cancer cells.","22251451","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","24039841",2013,"Estradiol and tamoxifen induce cell migration through GPR30 and activation of focal adhesion kinase (FAK) in endometrial cancers with low or without nuclear estrogen receptor ? (ER?).","24039841","Estradiol","Receptor, Epidermal Growth Factor"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L516,L516)","v":"Estradiol"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M516,M516)","v":"Receptor, Epidermal Growth Factor"},1,0,1,0,"EGFR",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K516,K516)","v":"11968000"},2002,"Identification and characterization of a negative regulatory element within the epidermal growth factor receptor gene first intron in hormone-dependent breast cancer cells.","11968000","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","23142484",2013,"Estrogen defines the dynamics and destination of transactivated EGF receptor in breast cancer cells: role of S1P? receptor and Cdc42.","23142484","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","2322651",1990,"Role of transforming growth factor-alpha-related peptides in the autocrine/paracrine control of experimental breast cancer growth in vitro by estradiol, prolactin, and progesterone.","2322651","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","23135268",2012,"G protein-coupled estrogen receptor mediates the up-regulation of fatty acid synthase induced by 17?-estradiol in cancer cells and cancer-associated fibroblasts.","23135268","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","12095935",2002,"Modulation of epidermal growth factor receptor in endocrine-resistant, estrogen-receptor-positive breast cancer.","12095935","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","10459848",1999,"Growth response of breast epithelial cells to estrogen is influenced by EGF.","10459848","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","23374155",2013,"Evaluation of the coordinated actions of estrogen receptors with epidermal growth factor receptor and insulin-like growth factor receptor in the expression of cell surface heparan sulfate proteoglycans and cell motility in breast cancer cells.","23374155","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","12067985",2002,"Association of interferon regulatory factor-1, nucleophosmin, nuclear factor-kappaB, and cyclic AMP response element binding with acquired resistance to Faslodex (ICI 182,780).","12067985","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","23399957",2013,"Antiestrogen fulvestrant enhances the antiproliferative effects of epidermal growth factor receptor inhibitors in human non-small-cell lung cancer.","23399957","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","17158205",2007,"2-methoxyestradiol induces mammary gland differentiation through amphiregulin-epithelial growth factor receptor-mediated signaling: molecular distinctions from the mammary gland of pregnant mice.","17158205","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","2289633",1990,"2,3,7,8-Tetrachlorodibenzo-p-dioxin inhibition of 17 beta-estradiol-induced increases in rat uterine epidermal growth factor receptor binding activity and gene expression.","2289633","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","16571873",2006,"Membrane initiated estrogen signaling in breast cancer.","16571873","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","10545803",1999,"Molecular bases for the actions of ovarian sex steroids in the regulation of proliferation and apoptosis of human uterine leiomyoma.","10545803","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","17261767",2006,"Crosstalk between EGFR and extranuclear steroid receptors.","17261767","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","11960991",2002,"Mechanism of 17-beta-estradiol-induced Erk1/2 activation in breast cancer cells. A role for HER2 AND PKC-delta.","11960991","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","10601607",2000,"Regulation of estrogen receptor and epidermal growth factor receptor by tamoxifen under high and low estrogen environments in MCF-7 cells grown in athymic mice.","10601607","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","3242819",1988,"Regulation of human estrogen receptor gene, epidermal growth factor receptor gene, and oncogenes by estrogen and antiestrogen in MCF-7 breast cancer cells.","3242819","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","1720427",1991,"Estradiol and EGF requirements for cell-cycle progression of normal human mammary epithelial cells in culture.","1720427","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","17959712",2008,"17beta-estradiol promotes breast cancer cell proliferation-inducing stromal cell-derived factor-1-mediated epidermal growth factor receptor transactivation: reversal by gefitinib pretreatment.","17959712","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","23641788",2013,"G protein-coupled estrogen receptor1 (GPER1) may mediate Rho-kinase (ROCK-2) up-regulation in coronary endothelial cells.","23641788","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","17106250",2006,"17beta-estradiol and tamoxifen stimulate rapid and transient ERK activationin MCF-7 cells via distinct signaling mechanisms.","17106250","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","23686416",2013,"Fulvestrant regulates epidermal growth factor (EGF) family ligands to activate EGF receptor (EGFR) signaling in breast cancer cells.","23686416","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","11773440",2002,"Estrogen action via the G protein-coupled receptor, GPR30: stimulation of adenylyl cyclase and cAMP-mediated attenuation of the epidermal growth factor receptor-to-MAPK signaling axis.","11773440","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","2382999",1990,"Morphological changes induced by epidermal growth factor and estradiol on CG5 human breast cancer cell line: a scanning electron microscopy study.","2382999","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","3454125",1987,"Interactions between estrogen and EGF in uterine growth and function.","3454125","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","2784313",1989,"Regulation of epidermal growth factor-receptor by estrogen and antiestrogen in the human breast cancer cell line MCF-7.","2784313","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","1740683",1992,"Aromatase activity and estradiol in human breast cancer: its relationship to estradiol and epidermal growth factor receptors and to tumor-node-metastasis staging.","1740683","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","2631032",1989,"[Epidermal growth factor induces the progesterone receptor in fetal uterine cells in culture: antagonistic effect of antiestrogens].","2631032","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","11043579",2000,"Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF.","11043579","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","2784840",1989,"Regulation of uterine epidermal growth factor (EGF) receptors by estrogen in the mature rat and during the estrous cycle.","2784840","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","10810313",2000,"Transforming growth factor-alpha stimulates proliferation of mammotrophs and corticotrophs in the mouse pituitary.","10810313","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","12894229",2003,"Oestrogens and selective oestrogen receptor (ER) modulators regulate EGF receptor gene expression through human ER alpha and beta subtypes via an Sp1 site.","12894229","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","10972181",2000,"Epidermal growth factor and 17beta-estradiol effects on proliferation of a human gastric cancer cell line (AGS).","10972181","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","22142990",2012,"Estradiol increases cell growth in human astrocytoma cell lines through ER? activation and its interaction with SRC-1 and SRC-3 coactivators.","22142990","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","24398390",2014,"Smoking out reproductive hormone actions in lung cancer.","24398390","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","10830317",2000,"Identification of an estrogen-mediated deoxyribonucleic acid-binding independent transactivation pathway on the epidermal growth factor receptor gene promoter.","10830317","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","22147081",2012,"GPER mediates the Egr-1 expression induced by 17?-estradiol and 4-hydroxitamoxifen in breast and endometrial cancer cells.","22147081","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,1,"EGFR","8888411",1996,"Methoxychlor mimics the action of 17 beta-estradiol on induction of uterine epidermal growth factor receptors in immature female rats.","8888411","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","8770893",1996,"Bimodal regulation of epidermal growth factor receptor by estrogen in breast cancer cells.","8770893","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","8882285",1996,"Regulation of epidermal growth factor receptor synthesis by ovarian steroids in human endometrial cells in culture.","8882285","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","8311931",1993,"Estrogen induces expression of endometrial epidermal growth factor receptors before implantation.","8311931","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","9141535",1997,"In vivo estrogen regulation of epidermal growth factor receptor in human endometrium.","9141535","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","9216645",1997,"Mechanism of growth inhibition by calpain inhibitor in MCF-7 cells.","9216645","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","7507841",1994,"Differential expression of epidermal growth factor receptor (EGF-R) gene and regulation of EGF-R bioactivity by progesterone and estrogen in the adult mouse uterus.","7507841","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","9605431",1998,"Interruption of estradiol signal transduction by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) through disruption of the protein phosphorylation pathway in adipose tissues from immature and mature female rats.","9605431","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","9605408",1998,"Estrogen regulation of transforming growth factor-alpha in ovarian cancer.","9605408","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","7865848",1994,"Establishment and characteristics of two new human mammary carcinoma lines in nude mice with special reference to the estradiol receptor status and the importance of stroma for in vivo and in vitro growth.","7865848","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","8814683",1996,"Short-term effects of pure anti-oestrogen ICI 182780 treatment on oestrogen receptor, epidermal growth factor receptor and transforming growth factor-alpha protein expression in human breast cancer.","8814683","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","8458346",1993,"The estrogen receptor cooperates with the TGF alpha receptor (c-erbB) in regulation of chicken erythroid progenitor self-renewal.","8458346","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","9877030",1998,"Inhibition of cell proliferation by 17beta-estradiol and heregulin beta1 in estrogen receptor negative human breast carcinoma cell lines.","9877030","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","7533260",1994,"Induction of estrogen independence of ZR-75-1 human breast cancer cells by epigenetic alterations.","7533260","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","9640268",1998,"Development of oestrogen receptor expression and hormone response in the uterus of the bovine fetus.","9640268","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","8616829",1996,"Reduced levels of cathepsin D associated with tamoxifen resistance and estrogen independence in the ZR-75-1 human breast cancer cell line.","8616829","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","9389529",1997,"Regulation of expression of epidermal growth factor receptors in gonadotropes by epidermal growth factor and estradiol: studies in cycling female rats.","9389529","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","9001345",1996,"Immunohistochemical study of estradiol, epidermal growth factor, transforming growth factor alpha and epidermal growth factor receptor in endometrial neoplasia.","9001345","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","7696175",1994,"Emergence of MCF-7 cells overexpressing a transfected epidermal growth factor receptor (EGFR) under estrogen-depleted conditions: evidence for a role of EGFR in breast cancer growth and progression.","7696175","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","8248035",1993,"Epidermal growth factor (EGF) replaces estradiol for the initiation of embryo implantation in the hypophysectomized rat.","8248035","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","8012064",1993,"Growth factors interact with estradiol and gonadotropins in the regulation of ovarian cancer cell growth and growth factor receptors.","8012064","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","9769151",1998,"BG-1 ovarian cell line: an alternative model for examining estrogen-dependent growth in vitro.","9769151","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","8595162",1996,"Expression of receptors for epidermal growth factor and insulin-like growth factor I by ZR-75-1 human breast cancer cell variants is inversely related: the effect of steroid hormones on insulin-like growth factor I receptor expression.","8595162","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","7654008",1995,"Growth regulation by estradiol, progesterone and recombinant human epidermal growth factor of human breast carcinoma xenografts grown serially in nude mice.","7654008","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","7706855",1995,"[Effects of estrogen and thyroid hormone on EGF receptor expression, proliferative activity and SCC production in the CaSki cervical carcinoma cells].","7706855","Estradiol","Receptor, Epidermal Growth Factor"]
["Estradiol","Receptors, LDL",1,0,1,0,"LDLR","15044370",2004,"The low-density lipoprotein receptor is regulated by estrogen and forms a functional complex with the estrogen-regulated protein ezrin in pituitary GH3 somatolactotropes.","15044370","Estradiol","Receptors, LDL"]
["Estradiol","Receptors, LDL",1,0,1,0,"LDLR","10224158",1999,"Protection against atherosclerosis by estrogen is independent of plasma cholesterol levels in LDL receptor-deficient mice.","10224158","Estradiol","Receptors, LDL"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L580,L580)","v":"Estradiol"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M580,M580)","v":"Receptors, LDL"},1,0,1,1,"LDLR",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K580,K580)","v":"23395521"},2013,"17-? Estradiol reduces atherosclerosis without exacerbating lupus in ovariectomized systemic lupus erythematosus-susceptible LDLr(-/-) mice.","23395521","Estradiol","Receptors, LDL"]
["Estradiol","Receptors, LDL",1,0,1,0,"LDLR","11429618",2001,"Activation of IP(3)-protein kinase C-alpha signal transduction pathway precedes the changes of plasma cholesterol, hepatic lipid metabolism and induction of low-density lipoprotein receptor expression in 17-beta-oestradiol-treated rats.","11429618","Estradiol","Receptors, LDL"]
["Estradiol","Receptors, LDL",1,0,1,0,"LDLR","17690314",2007,"Transforming growth factor activity is a key determinant for the effect of estradiol on fatty streak deposit in hypercholesterolemic mice.","17690314","Estradiol","Receptors, LDL"]
["Estradiol","Receptors, LDL",1,0,1,0,"LDLR","10864789",2000,"Influence of season and low-level oestradiol immunoneutralization on episodic LH and testosterone secretion and testicular steroidogenic enzymes and steroidogenic acute regulatory protein in the adult ram.","10864789","Estradiol","Receptors, LDL"]
["Estradiol","Receptors, LDL",1,0,1,0,"LDLR","19996016",2009,"Endothelial estrogen receptor-alpha plays a crucial role in the atheroprotective action of 17beta-estradiol in low-density lipoprotein receptor-deficient mice.","19996016","Estradiol","Receptors, LDL"]
["Estradiol","Receptors, LDL",1,0,1,0,"LDLR","2822102",1987,"Estrogens induce low-density lipoprotein receptor activity and decrease intracellular cholesterol in human hepatoma cell line Hep G2.","2822102","Estradiol","Receptors, LDL"]
["Estradiol","Receptors, LDL",1,0,1,0,"LDLR","23083679",2013,"Does 17?-estradiol play a role in SLE-associated atherosclerosis?","23083679","Estradiol","Receptors, LDL"]
["Estradiol","Receptors, LDL",1,0,1,0,"LDLR","16293557",2005,"Estrogenic regulation of cholesterol biosynthesis and cell growth in DLD-1 human colon cancer cells.","16293557","Estradiol","Receptors, LDL"]
["Estradiol","Receptors, LDL",1,0,1,0,"LDLR","1797939",1991,"In vivo regulation of apolipoprotein A-I gene expression by estradiol and testosterone occurs by different mechanisms in inbred strains of mice.","1797939","Estradiol","Receptors, LDL"]
["Estradiol","Receptors, LDL",1,0,1,0,"LDLR","22234464",2012,"Lipocalin 2 deficiency alters estradiol production and estrogen receptor signaling in female mice.","22234464","Estradiol","Receptors, LDL"]
["Estradiol","Receptors, LDL",1,0,1,0,"LDLR","17905649",2007,"High-density lipoprotein-associated 17beta-estradiol fatty acyl ester uptake by Fu5AH hepatoma cells: implications of the roles of scavenger receptor class B, type I and the low-density lipoprotein receptor.","17905649","Estradiol","Receptors, LDL"]
["Estradiol","Receptors, LDL",1,0,1,0,"LDLR","3477810",1987,"Isolation and characterization of three endosomal fractions from the liver of estradiol-treated rats.","3477810","Estradiol","Receptors, LDL"]
["Estradiol","Receptors, LDL",1,0,1,0,"LDLR","15972970",2005,"The atheroprotective effect of 17beta-estradiol depends on complex interactions in adaptive immunity.","15972970","Estradiol","Receptors, LDL"]
["Estradiol","Receptors, LDL",1,0,1,0,"LDLR","17346883",2007,"Estradiol replacement increases the low-density lipoprotein receptor related protein (LRP) in the mouse brain.","17346883","Estradiol","Receptors, LDL"]
["Estradiol","Receptors, LDL",1,0,1,0,"LDLR","11205278",2000,"Induction of estradiol synthesis by probucol in the adenocarcinoma cells of an ovarian clear cell tumor.","11205278","Estradiol","Receptors, LDL"]
["Estradiol","Receptors, LDL",1,0,1,0,"LDLR","10894823",2000,"Biphasic effects of the natural estrogen 17beta-estradiol on hepatic cholesterol metabolism in intact female rats.","10894823","Estradiol","Receptors, LDL"]
["Estradiol","Receptors, LDL",1,0,1,0,"LDLR","9788750",1998,"Regulation of low density lipoprotein receptor mRNA levels by estradiol 17beta and chorionic gonadotropin in human placenta.","9788750","Estradiol","Receptors, LDL"]
["Estradiol","Receptors, LDL",1,0,1,0,"LDLR","9275065",1997,"Androgen receptor-mediated antagonism of estrogen-dependent low density lipoprotein receptor transcription in cultured hepatocytes.","9275065","Estradiol","Receptors, LDL"]
["Estradiol","Receptors, LDL",1,0,1,0,"LDLR","9558734",1998,"Regulation of the LDL receptor gene expression by hormones.","9558734","Estradiol","Receptors, LDL"]
["Estradiol","Receptors, LDL",1,0,1,1,"LDLR","9402089",1997,"Estrogen replacement during hypoalbuminemia may enhance atherosclerotic risk.","9402089","Estradiol","Receptors, LDL"]
["Estradiol","Receptors, LDL",1,0,1,0,"LDLR","8692027",1996,"Estrogen increases low-density lipoprotein receptor-independent catabolism of apolipoprotein B in hyperlipidemic rabbits.","8692027","Estradiol","Receptors, LDL"]
["Estradiol","Matrix Metalloproteinase 1",1,0,1,0,"MMP1","16223974",2006,"Antagonist-induced, activation function-2-independent estrogen receptor alpha phosphorylation.","16223974","Estradiol","Matrix Metalloproteinase 1"]
["Estradiol","Matrix Metalloproteinase 1",1,0,1,0,"MMP1","14722210",2004,"Dual effects of 17beta-oestradiol on interleukin 1beta-induced proteoglycan degradation in chondrocytes.","14722210","Estradiol","Matrix Metalloproteinase 1"]
["Estradiol","Matrix Metalloproteinase 1",1,0,1,0,"MMP1","16280215",2006,"Effects of 17beta-estradiol on matrix metalloproteinase-1 synthesis by human dermal fibroblasts.","16280215","Estradiol","Matrix Metalloproteinase 1"]
["Estradiol","Matrix Metalloproteinase 1",1,0,1,0,"MMP1","11762702",2001,"Effects of 17beta-estradiol on the expression of matrix metalloproteinase-1, -2 and tissue inhibitor of metalloproteinase-1 in human osteoblast-like cell cultures.","11762702","Estradiol","Matrix Metalloproteinase 1"]
["Estradiol","Matrix Metalloproteinase 1",1,0,1,0,"MMP1","20600708",2010,"Bisphenol-A interferes with estradiol-mediated protection in osteoarthritic chondrocytes.","20600708","Estradiol","Matrix Metalloproteinase 1"]
["Estradiol","Matrix Metalloproteinase 1",1,0,1,0,"MMP1","15955089",2005,"Topical application of 17beta-estradiol increases extracellular matrix protein synthesis by stimulating tgf-Beta signaling in aged human skin in vivo.","15955089","Estradiol","Matrix Metalloproteinase 1"]
["Estradiol","Matrix Metalloproteinase 1",1,0,1,0,"MMP1","12861139",2003,"Differences in estrogen modulation of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-1 expression in cultured fibroblasts from continent and incontinent women.","12861139","Estradiol","Matrix Metalloproteinase 1"]
["Estradiol","Matrix Metalloproteinase 1",1,0,1,0,"MMP1","8982755",1996,"Regulation and restricted expression of interstitial collagenase suggest a pivotal role in the initiation of menstruation.","8982755","Estradiol","Matrix Metalloproteinase 1"]
["Estradiol","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","16386257",2006,"Role of annexin II in estrogen-induced macrophage matrix metalloproteinase-9 activity: the modulating effect of statins.","16386257","Estradiol","Matrix Metalloproteinase 9"]
["Estradiol","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","21664947",2011,"The effects of human chorionic gonadotrophin, progesterone and oestradiol on trophoblast function.","21664947","Estradiol","Matrix Metalloproteinase 9"]
["Estradiol","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","11950190",2002,"The effect of oestradiol on vaginal collagen metabolism in postmenopausal women with genuine stress incontinence.","11950190","Estradiol","Matrix Metalloproteinase 9"]
["Estradiol","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","16534014",2006,"Estradiol enhances recovery after myocardial infarction by augmenting incorporation of bone marrow-derived endothelial progenitor cells into sites of ischemia-induced neovascularization via endothelial nitric oxide synthase-mediated activation of matrix metalloproteinase-9.","16534014","Estradiol","Matrix Metalloproteinase 9"]
["Estradiol","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","11514328",2001,"Cellular turnover in the mammary gland is correlated with systemic levels of progesterone and not 17beta-estradiol during the estrous cycle.","11514328","Estradiol","Matrix Metalloproteinase 9"]
["Estradiol","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","22015101",2011,"Effects of an estrogen receptor antagonist on proliferation, prolactin secretion and growth factor expression in the MMQ pituitary prolactinoma cell line.","22015101","Estradiol","Matrix Metalloproteinase 9"]
["Estradiol","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","17888430",2008,"Increased expression of c-fos protein associated with increased matrix metalloproteinase-9 protein expression in the endometrium of endometriotic patients.","17888430","Estradiol","Matrix Metalloproteinase 9"]
["Estradiol","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","20504902",2010,"Estrogen improves TIMP-MMP balance and collagen distribution in volume-overloaded hearts of ovariectomized females.","20504902","Estradiol","Matrix Metalloproteinase 9"]
["Estradiol","Matrix Metalloproteinase 9",1,0,1,1,"MMP9","18456672",2008,"Combination of estrogen and dioxin is involved in the pathogenesis of endometriosis by promoting chemokine secretion and invasion of endometrial stromal cells.","18456672","Estradiol","Matrix Metalloproteinase 9"]
["Estradiol","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","10389972",1999,"A comparative study of the effects of genistein and 2-methoxyestradiol on the proteolytic balance and tumour cell proliferation.","10389972","Estradiol","Matrix Metalloproteinase 9"]
["Estradiol","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","12648862",2003,"Tocolytic effects of formoterol are associated with local change in the progesterone/estradiol ratio.","12648862","Estradiol","Matrix Metalloproteinase 9"]
["Estradiol","Matrix Metalloproteinase 9",1,0,1,1,"MMP9","16969706",2007,"Phase I safety, pharmacokinetic and pharmacodynamic studies of 2-methoxyestradiol alone or in combination with docetaxel in patients with locally recurrent or metastatic breast cancer.","16969706","Estradiol","Matrix Metalloproteinase 9"]
["Estradiol","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","16212944",2005,"17beta-Estradiol attenuates blood-brain barrier disruption induced by cerebral ischemia-reperfusion injury in female rats.","16212944","Estradiol","Matrix Metalloproteinase 9"]
["Estradiol","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","15261308",2004,"Regulation of the lipopolysaccharide signal transduction pathway by 17beta-estradiol in macrophage cells.","15261308","Estradiol","Matrix Metalloproteinase 9"]
["Estradiol","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","17083925",2007,"Effect of 17beta-estradiol on apoptosis, IGF system components and gelatinases A and B in prostate cancer cells (PC-3).","17083925","Estradiol","Matrix Metalloproteinase 9"]
["Estradiol","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","14630092",2003,"Activation of matrix metalloproteinase-2 and -9 by 2- and 4-hydroxyestradiol.","14630092","Estradiol","Matrix Metalloproteinase 9"]
["Estradiol","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","12878732",2003,"Estrogen receptor-alpha mediates the brain antiinflammatory activity of estradiol.","12878732","Estradiol","Matrix Metalloproteinase 9"]
["Estradiol","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","21949833",2011,"Puerarin suppresses invasion and vascularization of endometriosis tissue stimulated by 17?-estradiol.","21949833","Estradiol","Matrix Metalloproteinase 9"]
["Estradiol","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","12088791",2002,"Effect of hormone replacement therapy on carotid arterial compliance in healthy postmenopausal women.","12088791","Estradiol","Matrix Metalloproteinase 9"]
["Estradiol","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","14533013",2003,"Differential effects of estradiol and raloxifene on collagen biosynthesis in cultured human skin fibroblasts.","14533013","Estradiol","Matrix Metalloproteinase 9"]
["Estradiol","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","11713237",2001,"Estrogen reduces the depth of resorption pits by disturbing the organic bone matrix degradation activity of mature osteoclasts.","11713237","Estradiol","Matrix Metalloproteinase 9"]
["Estradiol","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","18511016",2008,"Metabolic syndrome in postmenopausal women: the influence of oral or transdermal estradiol on inflammation and coagulation markers.","18511016","Estradiol","Matrix Metalloproteinase 9"]
["Estradiol","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","22496348",2012,"Increased MMPs expression and decreased contraction in the rat myometrium during pregnancy and in response to prolonged stretch and sex hormones.","22496348","Estradiol","Matrix Metalloproteinase 9"]
["Estradiol","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","22820604",2012,"Effects of 17?-estradiol on human corneal wound healing in vitro.","22820604","Estradiol","Matrix Metalloproteinase 9"]
["Estradiol","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","23856290",2013,"EMMPRIN-mediated induction of uterine and vascular matrix metalloproteinases during pregnancy and in response to estrogen and progesterone.","23856290","Estradiol","Matrix Metalloproteinase 9"]
["Estradiol","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","23615645",2013,"Differential effects of estradiol on carotid artery inflammation when administered early versus late after surgical menopause.","23615645","Estradiol","Matrix Metalloproteinase 9"]
["Estradiol","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","21816222",2011,"17?-estradiol attenuates breakdown of blood-brain barrier and hemorrhagic transformation induced by tissue plasminogen activator in cerebral ischemia.","21816222","Estradiol","Matrix Metalloproteinase 9"]
["Estradiol","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","19012101",2008,"Effects of estradiol and progestogens on tumor-necrosis factor-alpha-induced changes of biochemical markers for breast cancer growth and metastasis.","19012101","Estradiol","Matrix Metalloproteinase 9"]
["Estradiol","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","17399702",2007,"Estrogen up-regulation of metalloproteinase-2 and -9 expression in rabbit lacrimal glands.","17399702","Estradiol","Matrix Metalloproteinase 9"]
["Estradiol","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","1399148",1992,"Genes involved in tumor invasion and metastasis are differentially modulated by estradiol and progestin in human breast-cancer cells.","1399148","Estradiol","Matrix Metalloproteinase 9"]
["Estradiol","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","22640525",2013,"Effect of estrogen therapy on vascular perlecan and metalloproteinases 2 and 9 in castrated rats.","22640525","Estradiol","Matrix Metalloproteinase 9"]
["Estradiol","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","19424616",2009,"A cyclized peptide derived from alpha fetoprotein inhibits the proliferation of ER-positive canine mammary cancer cells.","19424616","Estradiol","Matrix Metalloproteinase 9"]
["Estradiol","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","11245078",1998,"Expression of type-I collagen and matrix metalloproteinase-9 mRNA in bone of castrated adult female rats: effects of estrogen.","11245078","Estradiol","Matrix Metalloproteinase 9"]
["Estradiol","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","12114891",2002,"Regulation of matrix metalloproteinase expression by estrogen in fibroblasts that are derived from the pelvic floor.","12114891","Estradiol","Matrix Metalloproteinase 9"]
["Estradiol","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","21760532",2011,"17?-estradiol inhibits oxidized low-density lipoprotein-induced increase in matrix metalloproteinase-9 expression in human macrophages.","21760532","Estradiol","Matrix Metalloproteinase 9"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L644,L644)","v":"Estradiol"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M644,M644)","v":"Matrix Metalloproteinase 9"},1,0,1,0,"MMP9",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K644,K644)","v":"17459227"},2007,"[The role of estrogen in the formation and development of abdominal aortic aneurysm: experiment with rats].","17459227","Estradiol","Matrix Metalloproteinase 9"]
["Estradiol","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","11245665",2001,"Estrogen prevents the lipopolysaccharide-induced inflammatory response in microglia.","11245665","Estradiol","Matrix Metalloproteinase 9"]
["Estradiol","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","19957338",2010,"Prevention of osteoporosis in mice after ovariectomy via allograft of microencapsulated ovarian cells.","19957338","Estradiol","Matrix Metalloproteinase 9"]
["Estradiol","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","19952306",2010,"Combination therapy of 17beta-estradiol and recombinant tissue plasminogen activator for experimental ischemic stroke.","19952306","Estradiol","Matrix Metalloproteinase 9"]
["Estradiol","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","19383343",2008,"Estradiol-estrogen receptor: a key interplay of the expression of syndecan-2 and metalloproteinase-9 in breast cancer cells.","19383343","Estradiol","Matrix Metalloproteinase 9"]
["Estradiol","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","17031577",2007,"MMP-2 and MMP-9 activity is regulated by estradiol and tamoxifen in cultured human breast cancer cells.","17031577","Estradiol","Matrix Metalloproteinase 9"]
["Estradiol","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","21859479",2011,"JNK suppression is essential for 17?-Estradiol inhibits prostaglandin E2-Induced uPA and MMP-9 expressions and cell migration in human LoVo colon cancer cells.","21859479","Estradiol","Matrix Metalloproteinase 9"]
["Estradiol","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","23209733",2012,"17ß-estradiol antagonizes the down-regulation of ER?/NOS-3 signaling in vascular endothelial dysfunction of female diabetic rats.","23209733","Estradiol","Matrix Metalloproteinase 9"]
["Estradiol","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","19933421",2010,"Estrogen attenuates chronic volume overload induced structural and functional remodeling in male rat hearts.","19933421","Estradiol","Matrix Metalloproteinase 9"]
["Estradiol","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","22302680",2012,"Estrogen suppresses expression of the matrix metalloproteinase inhibitor reversion-inducing cysteine-rich protein with Kazal motifs (RECK) within the mouse uterus.","22302680","Estradiol","Matrix Metalloproteinase 9"]
["Estradiol","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","22938817",2012,"17?-Oestradiol activates proteolysis and increases invasion through phosphatidylinositol 3-kinase pathway in human cervical cancer cells.","22938817","Estradiol","Matrix Metalloproteinase 9"]
["Estradiol","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","12915398",2003,"Response to sex hormones differs in atherosclerosis-susceptible and -resistant mice.","12915398","Estradiol","Matrix Metalloproteinase 9"]
["Estradiol","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","12725417",2003,"Estrogen-induced Ets-1 promotes capillary formation in an in vitro tumor angiogenesis model.","12725417","Estradiol","Matrix Metalloproteinase 9"]
["Estradiol","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","11447735",2001,"Estrogenic and antiestrogenic effects of raloxifene on collagen metabolism in breast cancer MCF-7 cells.","11447735","Estradiol","Matrix Metalloproteinase 9"]
["Estradiol","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","16670485",2006,"Comparative effects of estrogen on matrix metalloproteinases and cytokines in immortalized and primary human corneal epithelial cell cultures.","16670485","Estradiol","Matrix Metalloproteinase 9"]
["Estradiol","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","22402435",2012,"Estrogen activates matrix metalloproteinases-2 and -9 to increase beta amyloid degradation.","22402435","Estradiol","Matrix Metalloproteinase 9"]
["Estradiol","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","15153565",2004,"Glomerulosclerosis and tubulointerstitial fibrosis are attenuated with 17beta-estradiol in the aging Dahl salt sensitive rat.","15153565","Estradiol","Matrix Metalloproteinase 9"]
["Estradiol","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","16651433",2006,"Estradiol and tamoxifen regulate endostatin generation via matrix metalloproteinase activity in breast cancer in vivo.","16651433","Estradiol","Matrix Metalloproteinase 9"]
["Estradiol","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","9219732",1997,"Differential influence of antiestrogens on the in vitro release of gelatinases (type IV collagenases) by invasive and non-invasive breast cancer cells.","9219732","Estradiol","Matrix Metalloproteinase 9"]
["Estradiol","NF-E2-Related Factor 2",1,0,1,0,"NFE2L2","22948038",2013,"Nrf2-Keap1 antioxidant defense and cell survival signaling are upregulated by 17?-estradiol in homocysteine-treated dopaminergic SH-SY5Y cells.","22948038","Estradiol","NF-E2-Related Factor 2"]
["Estradiol","NF-E2-Related Factor 2",1,0,1,1,"NFE2L2","22072621",2012,"Induction of NAD(P)H-quinone oxidoreductase 1 by antioxidants in female ACI rats is associated with decrease in oxidative DNA damage and inhibition of estrogen-induced breast cancer.","22072621","Estradiol","NF-E2-Related Factor 2"]
["Estradiol","NF-E2-Related Factor 2",1,0,1,0,"NFE2L2","19138946",2008,"Resveratrol prevents estrogen-DNA adduct formation and neoplastic transformation in MCF-10F cells.","19138946","Estradiol","NF-E2-Related Factor 2"]
["Estradiol","NF-E2-Related Factor 2",1,0,1,0,"NFE2L2","20623181",2010,"Inhibition of estrogen signaling activates the NRF2 pathway in breast cancer.","20623181","Estradiol","NF-E2-Related Factor 2"]
["Estradiol","NF-E2-Related Factor 2",1,0,1,0,"NFE2L2","22730333",2012,"17?-estradiol regulates the expression of antioxidant enzymes in myocardial cells by increasing Nrf2 translocation.","22730333","Estradiol","NF-E2-Related Factor 2"]
["Estradiol","NF-E2-Related Factor 2",1,0,1,0,"NFE2L2","16198475",2005,"Repression of cancer protective genes by 17beta-estradiol: ligand-dependent interaction between human Nrf2 and estrogen receptor alpha.","16198475","Estradiol","NF-E2-Related Factor 2"]
["Estradiol","Receptors, Urokinase Plasminogen Activator",1,0,1,0,"PLAUR","19395996",2009,"Estradiol attenuates EGF-induced rapid uPAR mobilization and cell migration via the G-protein-coupled receptor 30 in ovarian cancer cells.","19395996","Estradiol","Receptors, Urokinase Plasminogen Activator"]
["Estradiol","Receptors, Urokinase Plasminogen Activator",1,0,1,0,"PLAUR","17170212",2006,"Progesterone initiates Wnt-beta-catenin signaling but estradiol is required for nuclear activation and synchronous proliferation of rat uterine stromal cells.","17170212","Estradiol","Receptors, Urokinase Plasminogen Activator"]
["Estradiol","Receptors, Urokinase Plasminogen Activator",1,0,1,0,"PLAUR","9662256",1998,"Oestradiol regulation of the components of the plasminogen-plasmin system in MDA-MB-231 human breast cancer cells stably expressing the oestrogen receptor.","9662256","Estradiol","Receptors, Urokinase Plasminogen Activator"]
["Estradiol","Serum Amyloid A Protein",1,0,1,0,"SAA1","12270582",2002,"Effects of low dose hormone replacement therapy on markers of inflammation in postmenopausal women.","12270582","Estradiol","Serum Amyloid A Protein"]
["Estradiol","E-Selectin",1,0,1,0,"SELE","20735828",2010,"Female sex hormones mediate the allergic lung reaction by regulating the release of inflammatory mediators and the expression of lung E-selectin in rats.","20735828","Estradiol","E-Selectin"]
["Estradiol","E-Selectin",1,0,1,0,"SELE","10854701",2000,"Tibolone inhibits leukocyte adhesion molecule expression in human endothelial cells.","10854701","Estradiol","E-Selectin"]
["Estradiol","E-Selectin",1,0,1,0,"SELE","10384138",1999,"Estrogen protects against cellular infiltration by reducing the expressions of E-selectin and IL-6 in endotoxin-induced uveitis.","10384138","Estradiol","E-Selectin"]
["Estradiol","E-Selectin",1,0,1,0,"SELE","12087872",2002,"Testosterone and estradiol modulate TNF-alpha-induced expression of adhesion molecules in endothelial cells.","12087872","Estradiol","E-Selectin"]
["Estradiol","E-Selectin",1,0,1,0,"SELE","11464371",2001,"[Changes in serum levels of C-reactive protein and the soluble adhesion molecules, sE-selectin and sICAM-1, after transdermal 17-beta estradiol replacement].","11464371","Estradiol","E-Selectin"]
["Estradiol","E-Selectin",1,0,1,0,"SELE","15345733",2004,"The effect of different doses of micronized 17beta-estradiol on C-reactive protein, interleukin-6, and lipids in older women.","15345733","Estradiol","E-Selectin"]
["Estradiol","E-Selectin",1,0,1,1,"SELE","11341495",2001,"Effects of oral and transdermal estrogen replacement therapy on markers of coagulation, fibrinolysis, inflammation and serum lipids and lipoproteins in postmenopausal women.","11341495","Estradiol","E-Selectin"]
["Estradiol","E-Selectin",1,0,1,0,"SELE","11948013",2002,"17beta-Estradiol inhibits cytokine induction of the human E-selectin promoter.","11948013","Estradiol","E-Selectin"]
["Estradiol","E-Selectin",1,0,1,0,"SELE","20138621",2010,"Estrogen attenuates vascular remodeling in Lp(a) transgenic mice.","20138621","Estradiol","E-Selectin"]
["Estradiol","E-Selectin",1,0,1,0,"SELE","12020745",2002,"Effects of testosterone and 17-beta-estradiol on TNF-alpha-induced E-selectin and VCAM-1 expression in endothelial cells. Analysis of the underlying receptor pathways.","12020745","Estradiol","E-Selectin"]
["Estradiol","E-Selectin",1,0,1,0,"SELE","18511016",2008,"Metabolic syndrome in postmenopausal women: the influence of oral or transdermal estradiol on inflammation and coagulation markers.","18511016","Estradiol","E-Selectin"]
["Estradiol","E-Selectin",1,0,1,0,"SELE","16145300",2005,"Estrogen, progesterone, and cardiovascular health: when shall we complete the puzzle?","16145300","Estradiol","E-Selectin"]
["Estradiol","E-Selectin",1,0,1,0,"SELE","16145306",2005,"Effects of transdermal and oral postmenopausal hormone therapy on vascular function: a randomized, placebo-controlled study in healthy postmenopausal women.","16145306","Estradiol","E-Selectin"]
["Estradiol","E-Selectin",1,0,1,0,"SELE","12121710",2002,"Effects of estrogen, progesterone, and combination exposure on interleukin-1 beta-induced expression of VCAM-1, ICAM-1, PECAM, and E-selectin by human female iliac artery endothelial cells.","12121710","Estradiol","E-Selectin"]
["Estradiol","E-Selectin",1,0,1,0,"SELE","11125785",2000,"Controlled ovarian hyperstimulation--a state of endothelial activation.","11125785","Estradiol","E-Selectin"]
["Estradiol","E-Selectin",1,0,1,0,"SELE","15194470",2004,"Estrogen-mediated protection against HIV Tat protein-induced inflammatory pathways in human vascular endothelial cells.","15194470","Estradiol","E-Selectin"]
["Estradiol","E-Selectin",1,0,1,0,"SELE","11689270",2001,"Glycaemic control and plasma lipoproteins in menopausal women with Type 2 diabetes treated with oral and transdermal combined hormone replacement therapy.","11689270","Estradiol","E-Selectin"]
["Estradiol","E-Selectin",1,0,1,0,"SELE","7506711",1994,"Estradiol enhances leukocyte binding to tumor necrosis factor (TNF)-stimulated endothelial cells via an increase in TNF-induced adhesion molecules E-selectin, intercellular adhesion molecule type 1, and vascular cell adhesion molecule type 1.","7506711","Estradiol","E-Selectin"]
["Estradiol","E-Selectin",1,0,1,0,"SELE","7527406",1994,"Effects of 17 beta-estradiol on circulating adhesion molecules.","7527406","Estradiol","E-Selectin"]
["Estradiol","E-Selectin",1,0,1,0,"SELE","9052593",1997,"Parturition: steroids, prostaglandin E2, and expression of adhesion molecules by endothelial cells.","9052593","Estradiol","E-Selectin"]
["Estradiol","E-Selectin",1,0,1,0,"SELE","8548848",1996,"Modulation of endothelial cell expression of ICAM-1, E-selectin, and VCAM-1 by beta-estradiol, progesterone, and dexamethasone.","8548848","Estradiol","E-Selectin"]
["Estradiol","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","21859479",2011,"JNK suppression is essential for 17?-Estradiol inhibits prostaglandin E2-Induced uPA and MMP-9 expressions and cell migration in human LoVo colon cancer cells.","21859479","Estradiol","Plasminogen Activator Inhibitor 1"]
["Estradiol","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","16105968",2005,"Hemostatic factors and estrogen during the menopausal transition.","16105968","Estradiol","Plasminogen Activator Inhibitor 1"]
["Estradiol","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","18931023",2009,"Estradiol increases angiotensin II type 1 receptor in hearts of ovariectomized rats.","18931023","Estradiol","Plasminogen Activator Inhibitor 1"]
["Estradiol","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","11842041",2002,"Time- and dose-dependent differential upregulation of three genes by 17 beta-estradiol in endothelial cells.","11842041","Estradiol","Plasminogen Activator Inhibitor 1"]
["Estradiol","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","17686959",2007,"17beta-Estradiol attenuates diabetic kidney disease by regulating extracellular matrix and transforming growth factor-beta protein expression and signaling.","17686959","Estradiol","Plasminogen Activator Inhibitor 1"]
["Estradiol","Plasminogen Activator Inhibitor 1",1,0,1,1,"SERPINE1","11341495",2001,"Effects of oral and transdermal estrogen replacement therapy on markers of coagulation, fibrinolysis, inflammation and serum lipids and lipoproteins in postmenopausal women.","11341495","Estradiol","Plasminogen Activator Inhibitor 1"]
["Estradiol","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","23972791",2014,"Estrogen receptor alpha augments changes in hemostatic gene expression in HepG2 cells treated with estradiol and phytoestrogens.","23972791","Estradiol","Plasminogen Activator Inhibitor 1"]
["Estradiol","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","14557472",2003,"Insulin resistance, hemostatic factors, and hormone interactions in pre- and perimenopausal women: SWAN.","14557472","Estradiol","Plasminogen Activator Inhibitor 1"]
["Estradiol","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","17713346",2008,"Changes in hemostatic variables induced by estrogen replacement therapy: comparison of transdermal and oral administration in a crossover-designed study.","17713346","Estradiol","Plasminogen Activator Inhibitor 1"]
["Estradiol","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","18511016",2008,"Metabolic syndrome in postmenopausal women: the influence of oral or transdermal estradiol on inflammation and coagulation markers.","18511016","Estradiol","Plasminogen Activator Inhibitor 1"]
["Estradiol","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","24606183",2014,"2-Methoxyestradiol confers neuroprotection and inhibits a maladaptive HIF-1? response after traumatic brain injury in mice.","24606183","Estradiol","Plasminogen Activator Inhibitor 1"]
["Estradiol","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","11588944",2001,"Lipid-independent effects of an estrogen-statin combination: inhibition of expression of adhesion molecules and plasminogen activator inhibitor--I in human endothelial cell cultures.","11588944","Estradiol","Plasminogen Activator Inhibitor 1"]
["Estradiol","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","16337074",2006,"Effect of the cessation of long-term hormone replacement therapy on plasma plasminogen activator inhibitor-1 and fibrinogen.","16337074","Estradiol","Plasminogen Activator Inhibitor 1"]
["Estradiol","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","17264514",2007,"Effect of estrogen therapy on insulin resistance and plasminogen activator inhibitor type 1 concentrations in postmenopausal women.","17264514","Estradiol","Plasminogen Activator Inhibitor 1"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L708,L708)","v":"Estradiol"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M708,M708)","v":"Plasminogen Activator Inhibitor 1"},1,0,1,0,"SERPINE1",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K708,K708)","v":"19095343"},2009,"Short-term effects of two continuous combined oestrogen-progestogen therapies on several cardiovascular risk markers in healthy postmenopausal women: a randomised controlled trial.","19095343","Estradiol","Plasminogen Activator Inhibitor 1"]
["Estradiol","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","12732395",2003,"Double blind, randomized study of estradiol replacement therapy on markers of inflammation, coagulation and fibrinolysis.","12732395","Estradiol","Plasminogen Activator Inhibitor 1"]
["Estradiol","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","22389473",2012,"Estrogen regulates endothelial migration via plasminogen activator inhibitor (PAI-1).","22389473","Estradiol","Plasminogen Activator Inhibitor 1"]
["Estradiol","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","16192735",2006,"Effect of pulsed estrogen therapy on hemostatic markers in comparison with oral estrogen regimen in postmenopausal women.","16192735","Estradiol","Plasminogen Activator Inhibitor 1"]
["Estradiol","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","12567428",1999,"[Effect of 17 beta-estradiol on activity and gene expression of fibrinolytic factor in human umbilical vein endothelial cell].","12567428","Estradiol","Plasminogen Activator Inhibitor 1"]
["Estradiol","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","7629251",1995,"Plasminogen activator activity during decidualization of human endometrial stromal cells is regulated by plasminogen activator inhibitor 1.","7629251","Estradiol","Plasminogen Activator Inhibitor 1"]
["Estradiol","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","9041098",1997,"Effects of hormone-replacement therapy on fibrinolysis in postmenopausal women.","9041098","Estradiol","Plasminogen Activator Inhibitor 1"]
["Estradiol","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","9974378",1999,"A longitudinal study of the relationships between haemostatic, lipid, and oestradiol changes during normal human pregnancy.","9974378","Estradiol","Plasminogen Activator Inhibitor 1"]
["Estradiol","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","7748807",1995,"Induction of tissue plasminogen activator mRNA and activity by structurally altered estrogens.","7748807","Estradiol","Plasminogen Activator Inhibitor 1"]
["Estradiol","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","8794433",1996,"Transdermal estrogen replacement therapy: beneficial effects on hemostatic risk factors for cardiovascular disease.","8794433","Estradiol","Plasminogen Activator Inhibitor 1"]
["Estradiol","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","8140931",1994,"Characterization of the stromal osteogenic cell line MN7: mRNA steady-state level of selected osteogenic markers depends on cell density and is influenced by 17 beta-estradiol.","8140931","Estradiol","Plasminogen Activator Inhibitor 1"]
["Estradiol","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","9389781",1997,"The effects of transdermal oestradiol and oral progestogens on haemostasis variables.","9389781","Estradiol","Plasminogen Activator Inhibitor 1"]
["Estradiol","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","8650021",1995,"[Activity of plasminogen activator inhibitor (PAI-1) in plasma of women treated after menopause with hormone replacement therapy].","8650021","Estradiol","Plasminogen Activator Inhibitor 1"]
["Estradiol","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","8610774",1995,"The effect of estrogen replacement therapy with or without progestogen on the fibrinolytic system and coagulation inhibitors in postmenopausal status.","8610774","Estradiol","Plasminogen Activator Inhibitor 1"]
["Estradiol","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","7918843",1994,"The effect of two regimens of hormone replacement therapy on the haemostatic profile in postmenopausal women.","7918843","Estradiol","Plasminogen Activator Inhibitor 1"]
["Estradiol","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","9409295",1997,"Effects of oral and transdermal estrogen/progesterone regimens on blood coagulation and fibrinolysis in postmenopausal women. A randomized controlled trial.","9409295","Estradiol","Plasminogen Activator Inhibitor 1"]
["Estradiol","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","9243107",1997,"Short-term oestrogen replacement therapy improves insulin resistance, lipids and fibrinolysis in postmenopausal women with NIDDM.","9243107","Estradiol","Plasminogen Activator Inhibitor 1"]
["Estradiol","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","8267060",1993,"Fibrinolytic parameters in women undergoing ovulation induction.","8267060","Estradiol","Plasminogen Activator Inhibitor 1"]
["Estradiol","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","9662256",1998,"Oestradiol regulation of the components of the plasminogen-plasmin system in MDA-MB-231 human breast cancer cells stably expressing the oestrogen receptor.","9662256","Estradiol","Plasminogen Activator Inhibitor 1"]
["Estradiol","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","7599699",1995,"Effects of steroid hormones on fibrinolytic system in cultured human endometrial cells.","7599699","Estradiol","Plasminogen Activator Inhibitor 1"]
["Estradiol","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","8694045",1996,"The effect of specific hormones on fibrinolysis in pregnancy.","8694045","Estradiol","Plasminogen Activator Inhibitor 1"]
["Estradiol","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","9622279",1998,"Oral estrogen improves serum lipids, homocysteine and fibrinolysis in elderly men.","9622279","Estradiol","Plasminogen Activator Inhibitor 1"]
["Estradiol","Receptors, Thromboxane A2, Prostaglandin H2",1,0,1,0,"TBXA2R","8279549",1993,"Androgen regulation of thromboxane A2/prostaglandin H2 receptor expression in human erythroleukemia cells.","8279549","Estradiol","Receptors, Thromboxane A2, Prostaglandin H2"]
["Estradiol","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","19083056",2009,"Estrogen replacement therapy prevents airway dysfunction in a murine model of allergen-induced asthma.","19083056","Estradiol","Transforming Growth Factor beta1"]
["Estradiol","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","15998576",2005,"Follicular fluid concentration of transforming growth factor-beta1 is negatively correlated with estradiol and follicle size at the early stage of development of the first-wave cohort of bovine ovarian follicles.","15998576","Estradiol","Transforming Growth Factor beta1"]
["Estradiol","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","11912279",2002,"Transforming growth factor-beta1 inhibits steroidogenesis in human trophoblast cells.","11912279","Estradiol","Transforming Growth Factor beta1"]
["Estradiol","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","20962747",2011,"Testosterone and 17?-estradiol have opposite effects on podocyte apoptosis that precedes glomerulosclerosis in female estrogen receptor knockout mice.","20962747","Estradiol","Transforming Growth Factor beta1"]
["Estradiol","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","20472273",2010,"Effects of birth trauma and estrogen on urethral elastic fibers and elastin expression.","20472273","Estradiol","Transforming Growth Factor beta1"]
["Estradiol","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","12130550",2002,"Antigen presentation by vaginal cells: role of TGFbeta as a mediator of estradiol inhibition of antigen presentation.","12130550","Estradiol","Transforming Growth Factor beta1"]
["Estradiol","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","11737584",2001,"Protein kinase CK2 mediates TGF-beta1-stimulated type IV collagen gene transcription and its reversal by estradiol.","11737584","Estradiol","Transforming Growth Factor beta1"]
["Estradiol","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","15569304",2004,"Estradiol reverses renal injury in Alb/TGF-beta1 transgenic mice.","15569304","Estradiol","Transforming Growth Factor beta1"]
["Estradiol","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","11455579",2001,"Estrogen modulates estrogen receptor alpha and beta expression, osteogenic activity, and apoptosis in mesenchymal stem cells (MSCs) of osteoporotic mice.","11455579","Estradiol","Transforming Growth Factor beta1"]
["Estradiol","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","15107991",2004,"Transforming growth factor beta1-induced glomerulopathy is prevented by 17beta-estradiol supplementation.","15107991","Estradiol","Transforming Growth Factor beta1"]
["Estradiol","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","23926286",2013,"Transforming growth factor-beta 1 (TGF-B1) liberation from its latent complex during embryo implantation and its regulation by estradiol in mouse.","23926286","Estradiol","Transforming Growth Factor beta1"]
["Estradiol","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","20011585",2009,"Estradiol stimulates vasodilatory and metabolic pathways in cultured human endothelial cells.","20011585","Estradiol","Transforming Growth Factor beta1"]
["Estradiol","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","15762036",2004,"Effects of 17beta-estradiol, tamoxifen and raloxifene on the protein and mRNA expression of interleukin-6, transforming growth factor-beta1 and insulin-like growth factor-1 in primary human osteoblast cultures.","15762036","Estradiol","Transforming Growth Factor beta1"]
["Estradiol","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","19862801",2010,"Both nongenomic and genomic effects are involved in estradiol's enhancing the phenotype of smooth muscle cells in cultured prostate stromal cells.","19862801","Estradiol","Transforming Growth Factor beta1"]
["Estradiol","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","12094620",2001,"Isoflavones inhibit proliferation of ovarian cancer cells in vitro via an estrogen receptor-dependent pathway.","12094620","Estradiol","Transforming Growth Factor beta1"]
["Estradiol","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","18635743",2008,"Role of transforming growth factor-beta1 in gene expression and activity of estradiol and progesterone-generating enzymes in FSH-stimulated bovine granulosa cells.","18635743","Estradiol","Transforming Growth Factor beta1"]
["Estradiol","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","18644234",2008,"17beta-estradiol regulates the secretion of TGF-beta by cultured human dermal fibroblasts.","18644234","Estradiol","Transforming Growth Factor beta1"]
["Estradiol","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","15130513",2004,"Hormonal regulation of human trophoblast differentiation: a possible role for 17beta-estradiol and GnRH.","15130513","Estradiol","Transforming Growth Factor beta1"]
["Estradiol","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","15448735",2004,"Can transforming growth factor-beta1 and retinoids modify the activity of estradiol and antiestrogens in MCF-7 breast cancer cells?.","15448735","Estradiol","Transforming Growth Factor beta1"]
["Estradiol","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","12065890",2002,"A role for hypothalamic astrocytes in dehydroepiandrosterone and estradiol regulation of gonadotropin-releasing hormone (GnRH) release by GnRH neurons.","12065890","Estradiol","Transforming Growth Factor beta1"]
["Estradiol","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","17495854",2007,"Gender-specific effects of endogenous testosterone: female alpha-estrogen receptor-deficient C57Bl/6J mice develop glomerulosclerosis.","17495854","Estradiol","Transforming Growth Factor beta1"]
["Estradiol","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","17690314",2007,"Transforming growth factor activity is a key determinant for the effect of estradiol on fatty streak deposit in hypercholesterolemic mice.","17690314","Estradiol","Transforming Growth Factor beta1"]
["Estradiol","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","18190643",2008,"Regulation of proliferation and differentiation of prostatic stromal cells by oestradiol through prostatic epithelial cells in a paracrine manner.","18190643","Estradiol","Transforming Growth Factor beta1"]
["Estradiol","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","22393047",2012,"Protective role of estrogen-induced miRNA-29 expression in carbon tetrachloride-induced mouse liver injury.","22393047","Estradiol","Transforming Growth Factor beta1"]
["Estradiol","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","21521749",2011,"Active and total transforming growth factor-?1 are differentially regulated by dopamine and estradiol in the pituitary.","21521749","Estradiol","Transforming Growth Factor beta1"]
["Estradiol","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","12754131",2003,"[Transforming growth factor-beta1, estradiol, progesterone and lutropin levels in follicular fluid after ovarian stimulation].","12754131","Estradiol","Transforming Growth Factor beta1"]
["Estradiol","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","16284289",2005,"Opposing effects of oestradiol and progesterone on intracellular pathways and activation processes in the oxidative stress induced activation of cultured rat hepatic stellate cells.","16284289","Estradiol","Transforming Growth Factor beta1"]
["Estradiol","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","21129541",2010,"Effects of estrogen on lung development in a rat model of diaphragmatic hernia.","21129541","Estradiol","Transforming Growth Factor beta1"]
["Estradiol","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","12427123",2002,"Estradiol reverses TGF-beta1-induced mesangial cell apoptosis by a casein kinase 2-dependent mechanism.","12427123","Estradiol","Transforming Growth Factor beta1"]
["Estradiol","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","17093064",2006,"Smoking induces glomerulosclerosis in aging estrogen-deficient mice through cross-talk between TGF-beta1 and IGF-I signaling pathways.","17093064","Estradiol","Transforming Growth Factor beta1"]
["Estradiol","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","22028442",2012,"Relaxin and castration in male mice protect from, but testosterone exacerbates, age-related cardiac and renal fibrosis, whereas estrogens are an independent determinant of organ size.","22028442","Estradiol","Transforming Growth Factor beta1"]
["Estradiol","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","21200384",2011,"Estrogen enhances the functions of CD4(+)CD25(+)Foxp3(+) regulatory T cells that suppress osteoclast differentiation and bone resorption in vitro.","21200384","Estradiol","Transforming Growth Factor beta1"]
["Estradiol","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","16280215",2006,"Effects of 17beta-estradiol on matrix metalloproteinase-1 synthesis by human dermal fibroblasts.","16280215","Estradiol","Transforming Growth Factor beta1"]
["Estradiol","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","18034699",2007,"Ethanol alters production and secretion of estrogen-regulated growth factors that control prolactin-secreting tumors in the pituitary.","18034699","Estradiol","Transforming Growth Factor beta1"]
["Estradiol","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","21315800",2011,"Estradiol modulates TGF-?1 expression and its signaling pathway in thyroid stromal cells.","21315800","Estradiol","Transforming Growth Factor beta1"]
["Estradiol","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","12480960",2003,"Estradiol is nephroprotective in the rat remnant kidney.","12480960","Estradiol","Transforming Growth Factor beta1"]
["Estradiol","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","15955089",2005,"Topical application of 17beta-estradiol increases extracellular matrix protein synthesis by stimulating tgf-Beta signaling in aged human skin in vivo.","15955089","Estradiol","Transforming Growth Factor beta1"]
["Estradiol","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","15961557",2005,"Dopamine, dopamine D2 receptor short isoform, transforming growth factor (TGF)-beta1, and TGF-beta type II receptor interact to inhibit the growth of pituitary lactotropes.","15961557","Estradiol","Transforming Growth Factor beta1"]
["Estradiol","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","21248144",2011,"Estrogens promote invasion of prostate cancer cells in a paracrine manner through up-regulation of matrix metalloproteinase 2 in prostatic stromal cells.","21248144","Estradiol","Transforming Growth Factor beta1"]
["Estradiol","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","18479947",2008,"The effect of TGF-beta1 and beta-estradiol on glycosaminoglycan and type II collagen distribution in articular chondrocyte cultures.","18479947","Estradiol","Transforming Growth Factor beta1"]
["Estradiol","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","12567429",1999,"[Effects of growth factors and estrogen on the proliferation and prolactin gene expression in anterior pituitary cells of rats].","12567429","Estradiol","Transforming Growth Factor beta1"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L772,L772)","v":"Estradiol"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M772,M772)","v":"Thrombomodulin"},1,0,1,0,"THBD",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K772,K772)","v":"11014248"},2000,"17beta-estradiol, but not raloxifene, decreases thrombomodulin in the antithrombotic protein C pathway.","11014248","Estradiol","Thrombomodulin"]
["Estradiol","Thrombomodulin",1,0,1,0,"THBD","10625211",1999,"Upregulation of thrombomodulin antigen levels in U937 cells by combined stimulation with estradiol-17beta and vitamin K2 (menaquinone 4).","10625211","Estradiol","Thrombomodulin"]
["Estradiol","Tissue Inhibitor of Metalloproteinase-1",1,0,1,0,"TIMP1","23881388",2013,"TIMP1 overexpression mediates resistance of MCF-7 human breast cancer cells to fulvestrant and down-regulates progesterone receptor expression.","23881388","Estradiol","Tissue Inhibitor of Metalloproteinase-1"]
["Estradiol","Tissue Inhibitor of Metalloproteinase-1",1,0,1,0,"TIMP1","23085002",2013,"The chondroprotective effects of dehydroepiandrosterone probably exerted by its conversion to estradiol.","23085002","Estradiol","Tissue Inhibitor of Metalloproteinase-1"]
["Estradiol","Tissue Inhibitor of Metalloproteinase-1",1,0,1,0,"TIMP1","14722210",2004,"Dual effects of 17beta-oestradiol on interleukin 1beta-induced proteoglycan degradation in chondrocytes.","14722210","Estradiol","Tissue Inhibitor of Metalloproteinase-1"]
["Estradiol","Tissue Inhibitor of Metalloproteinase-1",1,0,1,0,"TIMP1","18511016",2008,"Metabolic syndrome in postmenopausal women: the influence of oral or transdermal estradiol on inflammation and coagulation markers.","18511016","Estradiol","Tissue Inhibitor of Metalloproteinase-1"]
["Estradiol","Tissue Inhibitor of Metalloproteinase-1",1,0,1,0,"TIMP1","22938817",2012,"17?-Oestradiol activates proteolysis and increases invasion through phosphatidylinositol 3-kinase pathway in human cervical cancer cells.","22938817","Estradiol","Tissue Inhibitor of Metalloproteinase-1"]
["Estradiol","Tissue Inhibitor of Metalloproteinase-1",1,0,1,0,"TIMP1","12861139",2003,"Differences in estrogen modulation of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-1 expression in cultured fibroblasts from continent and incontinent women.","12861139","Estradiol","Tissue Inhibitor of Metalloproteinase-1"]
["Estradiol","Tissue Inhibitor of Metalloproteinase-1",1,0,1,0,"TIMP1","11762702",2001,"Effects of 17beta-estradiol on the expression of matrix metalloproteinase-1, -2 and tissue inhibitor of metalloproteinase-1 in human osteoblast-like cell cultures.","11762702","Estradiol","Tissue Inhibitor of Metalloproteinase-1"]
["Estradiol","Tissue Inhibitor of Metalloproteinase-1",1,0,1,0,"TIMP1","17031577",2007,"MMP-2 and MMP-9 activity is regulated by estradiol and tamoxifen in cultured human breast cancer cells.","17031577","Estradiol","Tissue Inhibitor of Metalloproteinase-1"]
["Estradiol","Tissue Inhibitor of Metalloproteinase-1",1,0,1,0,"TIMP1","21949833",2011,"Puerarin suppresses invasion and vascularization of endometriosis tissue stimulated by 17?-estradiol.","21949833","Estradiol","Tissue Inhibitor of Metalloproteinase-1"]
["Estradiol","Tissue Inhibitor of Metalloproteinase-1",1,0,1,0,"TIMP1","20504902",2010,"Estrogen improves TIMP-MMP balance and collagen distribution in volume-overloaded hearts of ovariectomized females.","20504902","Estradiol","Tissue Inhibitor of Metalloproteinase-1"]
["Estradiol","Tissue Inhibitor of Metalloproteinase-1",1,0,1,0,"TIMP1","16280215",2006,"Effects of 17beta-estradiol on matrix metalloproteinase-1 synthesis by human dermal fibroblasts.","16280215","Estradiol","Tissue Inhibitor of Metalloproteinase-1"]
["Estradiol","Tissue Inhibitor of Metalloproteinase-1",1,0,1,0,"TIMP1","23209733",2012,"17ß-estradiol antagonizes the down-regulation of ER?/NOS-3 signaling in vascular endothelial dysfunction of female diabetic rats.","23209733","Estradiol","Tissue Inhibitor of Metalloproteinase-1"]
["Estradiol","Tissue Inhibitor of Metalloproteinase-1",1,0,1,0,"TIMP1","14568914",2004,"Steroidal regulation of uterine edema and tissue inhibitors of metalloproteinase (TIMP)-3 messenger RNA expression is altered in TIMP-1-deficient mice.","14568914","Estradiol","Tissue Inhibitor of Metalloproteinase-1"]
["Estradiol","Tissue Inhibitor of Metalloproteinase-1",1,0,1,0,"TIMP1","19383343",2008,"Estradiol-estrogen receptor: a key interplay of the expression of syndecan-2 and metalloproteinase-9 in breast cancer cells.","19383343","Estradiol","Tissue Inhibitor of Metalloproteinase-1"]
["Estradiol","Tissue Inhibitor of Metalloproteinase-1",1,0,1,0,"TIMP1","17010446",2007,"Doxycycline alters the expression of matrix metalloproteases in the endometrial cells exposed to ovarian steroids and pro-inflammatory cytokine.","17010446","Estradiol","Tissue Inhibitor of Metalloproteinase-1"]
["Estradiol","Tissue Inhibitor of Metalloproteinase-1",1,0,1,0,"TIMP1","12684836",2003,"Effect of estrogen on the expression of matrix metalloproteinase (MMP)-1, MMP-3, and MMP-13 and tissue inhibitor of metalloproternase-1 in osteoarthritis chondrocytes.","12684836","Estradiol","Tissue Inhibitor of Metalloproteinase-1"]
["Estradiol","Tissue Inhibitor of Metalloproteinase-1",1,0,1,0,"TIMP1","15609084",2004,"Effects of 17 beta-estradiol on the expression of interstitial collagenases-8 and -13 (MMP-8 and MMP-13) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in ovariectomized rat osteoblastic cells.","15609084","Estradiol","Tissue Inhibitor of Metalloproteinase-1"]
["Estradiol","Tissue Inhibitor of Metalloproteinase-1",1,0,1,0,"TIMP1","22028442",2012,"Relaxin and castration in male mice protect from, but testosterone exacerbates, age-related cardiac and renal fibrosis, whereas estrogens are an independent determinant of organ size.","22028442","Estradiol","Tissue Inhibitor of Metalloproteinase-1"]
["Estradiol","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","23095497",2013,"Estradiol modulates tumor necrosis factor-induced endothelial inflammation: role of tumor necrosis factor receptor 2.","23095497","Estradiol","Vascular Cell Adhesion Molecule-1"]
["Estradiol","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","10326626",1999,"Effect of estradiol and progesterone on the low-dose endotoxin-induced glomerular inflammatory response of the female rat.","10326626","Estradiol","Vascular Cell Adhesion Molecule-1"]
["Estradiol","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","11154129",2000,"Plasma 17beta estradiol is inversely correlated with circulating vascular cell adhesion molecule.","11154129","Estradiol","Vascular Cell Adhesion Molecule-1"]
["Estradiol","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","16501036",2006,"No increase in C-reactive protein levels during intranasal compared to oral hormone therapy in healthy post-menopausal women.","16501036","Estradiol","Vascular Cell Adhesion Molecule-1"]
["Estradiol","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","22465119",2012,"Divergent effects of 17-?-estradiol on human vascular smooth muscle and endothelial cell function diminishes TNF-?-induced neointima formation.","22465119","Estradiol","Vascular Cell Adhesion Molecule-1"]
["Estradiol","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","12070310",2002,"Estrogen alters thresholds for B cell apoptosis and activation.","12070310","Estradiol","Vascular Cell Adhesion Molecule-1"]
["Estradiol","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","10600091",1999,"A pilot study of estrogen's effects on bronchial myocyte adhesion molecule expression.","10600091","Estradiol","Vascular Cell Adhesion Molecule-1"]
["Estradiol","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","16145306",2005,"Effects of transdermal and oral postmenopausal hormone therapy on vascular function: a randomized, placebo-controlled study in healthy postmenopausal women.","16145306","Estradiol","Vascular Cell Adhesion Molecule-1"]
["Estradiol","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","18303079",2008,"A comparison of the short-term effects of oral conjugated equine estrogens versus transdermal estradiol on C-reactive protein, other serum markers of inflammation, and other hepatic proteins in naturally menopausal women.","18303079","Estradiol","Vascular Cell Adhesion Molecule-1"]
["Estradiol","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","16332375",2006,"17Beta-estradiol inhibits monocyte adhesion via down-regulation of Rac1 GTPase.","16332375","Estradiol","Vascular Cell Adhesion Molecule-1"]
["Estradiol","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","15158369",2004,"Suppression by 17beta-estradiol of monocyte adhesion to vascular endothelial cells is mediated by estrogen receptors.","15158369","Estradiol","Vascular Cell Adhesion Molecule-1"]
["Estradiol","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","12270582",2002,"Effects of low dose hormone replacement therapy on markers of inflammation in postmenopausal women.","12270582","Estradiol","Vascular Cell Adhesion Molecule-1"]
["Estradiol","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","10455066",1999,"Estradiol inhibits leukocyte adhesion and transendothelial migration in rabbits in vivo : possible mechanisms for gender differences in atherosclerosis.","10455066","Estradiol","Vascular Cell Adhesion Molecule-1"]
["Estradiol","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","12020745",2002,"Effects of testosterone and 17-beta-estradiol on TNF-alpha-induced E-selectin and VCAM-1 expression in endothelial cells. Analysis of the underlying receptor pathways.","12020745","Estradiol","Vascular Cell Adhesion Molecule-1"]
["Estradiol","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","10022460",1999,"Selective estrogen receptor modulators: different actions on vascular cell adhesion molecule-1 (VCAM-1) expression in human endothelial cells.","10022460","Estradiol","Vascular Cell Adhesion Molecule-1"]
["Estradiol","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","12121710",2002,"Effects of estrogen, progesterone, and combination exposure on interleukin-1 beta-induced expression of VCAM-1, ICAM-1, PECAM, and E-selectin by human female iliac artery endothelial cells.","12121710","Estradiol","Vascular Cell Adhesion Molecule-1"]
["Estradiol","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","15194470",2004,"Estrogen-mediated protection against HIV Tat protein-induced inflammatory pathways in human vascular endothelial cells.","15194470","Estradiol","Vascular Cell Adhesion Molecule-1"]
["Estradiol","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","16145300",2005,"Estrogen, progesterone, and cardiovascular health: when shall we complete the puzzle?","16145300","Estradiol","Vascular Cell Adhesion Molecule-1"]
["Estradiol","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","15501247",2004,"Tissue-specific effect of estradiol on endothelial cell-dependent lymphocyte recruitment.","15501247","Estradiol","Vascular Cell Adhesion Molecule-1"]
["Estradiol","Vascular Cell Adhesion Molecule-1",1,0,1,1,"VCAM1","17578864",2007,"Acceleration of autoimmunity by organochlorine pesticides: a comparison of splenic B-cell effects of chlordecone and estradiol in (NZBxNZW)F1 mice.","17578864","Estradiol","Vascular Cell Adhesion Molecule-1"]
["Estradiol","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","18255343",2008,"Inhibition of vascular inflammation by dehydroepiandrosterone sulfate in human aortic endothelial cells: roles of PPARalpha and NF-kappaB.","18255343","Estradiol","Vascular Cell Adhesion Molecule-1"]
["Estradiol","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","12087872",2002,"Testosterone and estradiol modulate TNF-alpha-induced expression of adhesion molecules in endothelial cells.","12087872","Estradiol","Vascular Cell Adhesion Molecule-1"]
["Estradiol","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","20138621",2010,"Estrogen attenuates vascular remodeling in Lp(a) transgenic mice.","20138621","Estradiol","Vascular Cell Adhesion Molecule-1"]
["Estradiol","Vascular Cell Adhesion Molecule-1",1,0,1,1,"VCAM1","16969706",2007,"Phase I safety, pharmacokinetic and pharmacodynamic studies of 2-methoxyestradiol alone or in combination with docetaxel in patients with locally recurrent or metastatic breast cancer.","16969706","Estradiol","Vascular Cell Adhesion Molecule-1"]
["Estradiol","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","11904449",2002,"Testosterone attenuates expression of vascular cell adhesion molecule-1 by conversion to estradiol by aromatase in endothelial cells: implications in atherosclerosis.","11904449","Estradiol","Vascular Cell Adhesion Molecule-1"]
["Estradiol","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","10854701",2000,"Tibolone inhibits leukocyte adhesion molecule expression in human endothelial cells.","10854701","Estradiol","Vascular Cell Adhesion Molecule-1"]
["Estradiol","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","19906002",2009,"Testosterone addition to estrogen therapy - effects on inflammatory markers for cardiovascular disease.","19906002","Estradiol","Vascular Cell Adhesion Molecule-1"]
["Estradiol","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","10884367",2000,"Estrogens and glucocorticoids inhibit endothelial vascular cell adhesion molecule-1 expression by different transcriptional mechanisms.","10884367","Estradiol","Vascular Cell Adhesion Molecule-1"]
["Estradiol","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","16186073",2005,"The effects of oral and transdermal hormone replacement therapy on C-reactive protein levels and other inflammatory markers in women with high risk of thrombosis.","16186073","Estradiol","Vascular Cell Adhesion Molecule-1"]
["Estradiol","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","12482549",2003,"The atheroprotective effect of 17 beta-estradiol is not altered in P-selectin- or ICAM-1-deficient hypercholesterolemic mice.","12482549","Estradiol","Vascular Cell Adhesion Molecule-1"]
["Estradiol","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","12547825",2003,"17-epiestriol, an estrogen metabolite, is more potent than estradiol in inhibiting vascular cell adhesion molecule 1 (VCAM-1) mRNA expression.","12547825","Estradiol","Vascular Cell Adhesion Molecule-1"]
["Estradiol","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","9052593",1997,"Parturition: steroids, prostaglandin E2, and expression of adhesion molecules by endothelial cells.","9052593","Estradiol","Vascular Cell Adhesion Molecule-1"]
["Estradiol","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","8548848",1996,"Modulation of endothelial cell expression of ICAM-1, E-selectin, and VCAM-1 by beta-estradiol, progesterone, and dexamethasone.","8548848","Estradiol","Vascular Cell Adhesion Molecule-1"]
["Estradiol","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","7527406",1994,"Effects of 17 beta-estradiol on circulating adhesion molecules.","7527406","Estradiol","Vascular Cell Adhesion Molecule-1"]
["Estradiol","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","7511198",1994,"Estradiol-17 beta regulates the induction of VCAM-1 mRNA expression by interleukin-1 beta in human umbilical vein endothelial cells.","7511198","Estradiol","Vascular Cell Adhesion Molecule-1"]
["Estradiol","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","7506711",1994,"Estradiol enhances leukocyte binding to tumor necrosis factor (TNF)-stimulated endothelial cells via an increase in TNF-induced adhesion molecules E-selectin, intercellular adhesion molecule type 1, and vascular cell adhesion molecule type 1.","7506711","Estradiol","Vascular Cell Adhesion Molecule-1"]
["Ethanolamine","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","16618207",2006,"Ethanolamine modulates DNA synthesis through epidermal growth factor receptor in rat primary hepatocytes.","16618207","Ethanolamine","Receptor, Epidermal Growth Factor"]
["Ethanolamine","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","9574810",1998,"Ethanolamine stimulates repair processes in acute CCl4 damage of mouse liver.","9574810","Ethanolamine","Receptor, Epidermal Growth Factor"]
["Ethinyl Estradiol","Macrophage Colony-Stimulating Factor",1,0,1,1,"CSF1","15925024",2005,"Myelotoxicity in genistein-, nonylphenol-, methoxychlor-, vinclozolin- or ethinyl estradiol-exposed F1 generations of Sprague-Dawley rats following developmental and adult exposures.","15925024","Ethinyl Estradiol","Macrophage Colony-Stimulating Factor"]
["Ethinyl Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","1835096",1991,"Stimulation of hepatocyte DNA synthesis by ethinyl estradiol.","1835096","Ethinyl Estradiol","Receptor, Epidermal Growth Factor"]
["Ethinyl Estradiol","Receptor, Epidermal Growth Factor",1,0,1,1,"EGFR","1672626",1991,"Estrogen receptor, epidermal growth factor receptor and cellular ploidy in elutriated subpopulations of hepatocytes during liver tumor promotion by 17 alpha-ethinylestradiol in rats.","1672626","Ethinyl Estradiol","Receptor, Epidermal Growth Factor"]
["Ethinyl Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","2786453",1989,"Effects of the liver tumor promoter ethinyl estradiol on epidermal growth factor-induced DNA synthesis and epidermal growth factor receptor levels in cultured rat hepatocytes.","2786453","Ethinyl Estradiol","Receptor, Epidermal Growth Factor"]
["Ethinyl Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","2197011",1990,"Regulation of rat hepatocyte epidermal growth factor receptor by the liver tumor promoter ethinyl estradiol.","2197011","Ethinyl Estradiol","Receptor, Epidermal Growth Factor"]
["Ethinyl Estradiol","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","8681437",1996,"Estrogen receptor levels and occupancy in hepatic sinusoidal endothelial and Kupffer cells are enhanced by initiation with diethylnitrosamine and promotion with 17alpha-ethinylestradiol in rats.","8681437","Ethinyl Estradiol","Receptor, Epidermal Growth Factor"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L836,L836)","v":"Ethinyl Estradiol"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M836,M836)","v":"Receptor, Epidermal Growth Factor"},1,0,1,0,"EGFR",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K836,K836)","v":"7955042"},1994,"Growth stimulation followed by growth inhibition in livers of female rats treated with ethinyl estradiol.","7955042","Ethinyl Estradiol","Receptor, Epidermal Growth Factor"]
["Ethinyl Estradiol","Receptors, LDL",1,0,1,0,"LDLR","2401854",1990,"Development, food intake, and ethinylestradiol influence hepatic triglyceride lipase and LDL-receptor mRNA levels in rats.","2401854","Ethinyl Estradiol","Receptors, LDL"]
["Ethinyl Estradiol","Receptors, LDL",1,0,1,1,"LDLR","22078205",2011,"Reciprocal coordination of a combination oral contraceptive containing desogestrel+ethinyl estradiol on the expression of LOX-1 and LDLR in placental trophoblast cells.","22078205","Ethinyl Estradiol","Receptors, LDL"]
["Ethinyl Estradiol","Receptors, LDL",1,0,1,0,"LDLR","4031649",1985,"Solubilization of the 17 alpha-ethinyl estradiol-stimulated low density lipoprotein receptor of male rat liver.","4031649","Ethinyl Estradiol","Receptors, LDL"]
["Ethinyl Estradiol","Receptors, LDL",1,0,1,0,"LDLR","21757058",2011,"Effect of a combination oral contraceptive (desogestrel+ethinyl estradiol) on the expression of low-density lipoprotein receptor and its transcription factor (SREBP2) in placental trophoblast cells.","21757058","Ethinyl Estradiol","Receptors, LDL"]
["Ethinyl Estradiol","Receptors, LDL",1,0,1,0,"LDLR","2614275",1989,"Regulation of hepatic cholesterol and lipoprotein metabolism in ethinyl estradiol-treated rats.","2614275","Ethinyl Estradiol","Receptors, LDL"]
["Ethinyl Estradiol","Receptors, LDL",1,0,1,0,"LDLR","3559401",1987,"Characterization of the estrogen-induced lipoprotein receptor of rat liver.","3559401","Ethinyl Estradiol","Receptors, LDL"]
["Ethinyl Estradiol","Receptors, LDL",1,0,1,0,"LDLR","10488433",1999,"Catabolism of HDL1 cholesteryl ester in the rat. Effect of ethinyl estradiol treatment.","10488433","Ethinyl Estradiol","Receptors, LDL"]
["Ethinyl Estradiol","Receptors, LDL",1,0,1,0,"LDLR","3580385",1987,"Role of the liver for the receptor-mediated catabolism of low-density lipoprotein in the 17 alpha-ethinylestradiol-treated rat.","3580385","Ethinyl Estradiol","Receptors, LDL"]
["Ethinyl Estradiol","Receptors, LDL",1,0,1,0,"LDLR","10729376",2000,"Effects of reserpine on expression of the LDL receptor in liver and on plasma and tissue lipids, low density lipoprotein and fibrinogen in rabbits in vivo.","10729376","Ethinyl Estradiol","Receptors, LDL"]
["Ethinyl Estradiol","Receptors, LDL",1,0,1,0,"LDLR","1495990",1992,"Importance of growth hormone for the induction of hepatic low density lipoprotein receptors.","1495990","Ethinyl Estradiol","Receptors, LDL"]
["Ethinyl Estradiol","Receptors, LDL",1,0,1,0,"LDLR","2418443",1986,"Increased mRNA for low density lipoprotein receptor in livers of rabbits treated with 17 alpha-ethinyl estradiol.","2418443","Ethinyl Estradiol","Receptors, LDL"]
["Ethinyl Estradiol","Receptors, LDL",1,0,1,0,"LDLR","12475377",2002,"Effect of estrogen on scavenger receptor BI expression in the rat.","12475377","Ethinyl Estradiol","Receptors, LDL"]
["Ethinyl Estradiol","Receptors, LDL",1,0,1,0,"LDLR","17900441",2007,"Study of low-density lipoprotein receptor regulation by oral (steroid) contraceptives: desogestrel, levonorgestrel and ethinyl estradiol in JEG-3 cell line and placental tissue.","17900441","Ethinyl Estradiol","Receptors, LDL"]
["Ethinyl Estradiol","Receptors, LDL",1,0,1,0,"LDLR","3955066",1986,"Low-density lipoprotein receptor activity in the guinea pig adrenal cortex. II. Zonal response to aminoglutethimide and 17 alpha-ethinylestradiol.","3955066","Ethinyl Estradiol","Receptors, LDL"]
["Ethinyl Estradiol","Receptors, LDL",1,0,1,0,"LDLR","8130270",1994,"Lack of effect on the low density lipoprotein receptor in hamsters treated with 17 alpha-ethinyl estradiol.","8130270","Ethinyl Estradiol","Receptors, LDL"]
["Ethinyl Estradiol","Receptors, LDL",1,0,1,0,"LDLR","8864965",1996,"Effect of hypocholesterolemic doses of 17 alpha-ethinyl estradiol on cholesterol balance in liver and extrahepatic tissues.","8864965","Ethinyl Estradiol","Receptors, LDL"]
["Ethinyl Estradiol","Receptors, LDL",1,0,1,0,"LDLR","8034005",1994,"Effects of estradiol on very low density lipoprotein receptor mRNA levels in rabbit heart.","8034005","Ethinyl Estradiol","Receptors, LDL"]
["Ethinyl Estradiol","Receptors, LDL",1,0,1,0,"LDLR","9359909",1997,"Independent responsiveness of frog liver low-density lipoprotein receptor and HMGCoA reductase to estrogen treatment.","9359909","Ethinyl Estradiol","Receptors, LDL"]
["Ethinyl Estradiol","Receptors, LDL",1,0,1,0,"LDLR","6329312",1984,"In vivo characteristics of a specific recognition site for LDL on non-parenchymal rat liver cells which differs from the 17 alpha-ethinyl estradiol-induced LDL receptor on parenchymal liver cells.","6329312","Ethinyl Estradiol","Receptors, LDL"]
["Ethinyl Estradiol","Receptors, LDL",1,0,1,0,"LDLR","7508915",1994,"17 alpha-ethinylestradiol increases transcytosis of asialoglycoproteins in rat liver.","7508915","Ethinyl Estradiol","Receptors, LDL"]
["Ethinyl Estradiol","Receptors, LDL",1,0,1,0,"LDLR","6299796",1983,"Cellular localization of the receptor-dependent and receptor-independent uptake of human LDL in the liver of normal and 17 alpha-ethinyl estradiol-treated rats.","6299796","Ethinyl Estradiol","Receptors, LDL"]
["Ethinyl Estradiol","Receptors, LDL",1,0,1,0,"LDLR","6270162",1981,"Hepatic binding and internalization of low density lipoprotein-gold conjugates in rats treated with 17 alpha-ethinylestradiol.","6270162","Ethinyl Estradiol","Receptors, LDL"]
["Ethinyl Estradiol","Receptors, LDL",1,0,1,0,"LDLR","8702393",1996,"Independent behavior of rat liver LDL receptor and HMGCoA reductase under estrogen treatment.","8702393","Ethinyl Estradiol","Receptors, LDL"]
["Ethinyl Estradiol","Receptors, LDL",1,0,1,0,"LDLR","7557883",1995,"Parenchymal and nonparenchymal uptake of technetium-99m, indium-111, and iodine-125 low-density lipoprotein in the normal and estradiol-stimulated rat liver: tracer validation for quantitative low-density lipoprotein scintigraphy.","7557883","Ethinyl Estradiol","Receptors, LDL"]
["Ethinyl Estradiol","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","22510229",2012,"Oral contraceptive containing chlormadinone acetate and ethinylestradiol reduces plasma concentrations of matrix metalloproteinase-2 in women with polycystic ovary syndrome.","22510229","Ethinyl Estradiol","Matrix Metalloproteinase 9"]
["Ethinyl Estradiol","Serum Amyloid A Protein",1,0,1,0,"SAA1","19888539",2009,"Short-term ethinyl estradiol treatment suppresses inferior caval vein thrombosis in obese mice.","19888539","Ethinyl Estradiol","Serum Amyloid A Protein"]
["Ethinyl Estradiol","E-Selectin",1,0,1,0,"SELE","22554799",2012,"Drospirenone and levonorgestrel in combination with either 30 or 20 mcg ethinylestradiol reduce soluble adhesion molecules in Brazilian women; cross-sectional study.","22554799","Ethinyl Estradiol","E-Selectin"]
["Ethinyl Estradiol","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","21485727",2011,"The effect of low-dose combined oral contraceptive containing 100 ug levonorgestrel on plasma plasminogen activator inhibitor-1 concentrations.","21485727","Ethinyl Estradiol","Plasminogen Activator Inhibitor 1"]
["Ethinyl Estradiol","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","17903073",2007,"Combined continuous ethinyl estradiol/norethindrone acetate does not improve forearm blood flow in postmenopausal women at risk for cardiovascular events: a pilot study.","17903073","Ethinyl Estradiol","Plasminogen Activator Inhibitor 1"]
["Ethinyl Estradiol","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","15504374",2004,"Clinical and metabolic aspects of the continuous use of a contraceptive association of ethinyl estradiol (30 microg) and gestodene (75 microg).","15504374","Ethinyl Estradiol","Plasminogen Activator Inhibitor 1"]
["Ethinyl Estradiol","Plasminogen Activator Inhibitor 1",1,0,1,1,"SERPINE1","10928462",2000,"Increased fibrinolytic activity during use of oral contraceptives is counteracted by an enhanced factor XI-independent down regulation of fibrinolysis: a randomized cross-over study of two low-dose oral contraceptives.","10928462","Ethinyl Estradiol","Plasminogen Activator Inhibitor 1"]
["Ethinyl Estradiol","Plasminogen Activator Inhibitor 1",1,0,1,1,"SERPINE1","19019358",2010,"Endothelial function and insulin resistance in polycystic ovary syndrome: the effects of medical therapy.","19019358","Ethinyl Estradiol","Plasminogen Activator Inhibitor 1"]
["Ethinyl Estradiol","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","8630312",1996,"The effect of oestrogen dose and progestogen type on haemostatic changes in women taking low dose oral contraceptives.","8630312","Ethinyl Estradiol","Plasminogen Activator Inhibitor 1"]
["Ethinyl Estradiol","Plasminogen Activator Inhibitor 1",1,0,1,1,"SERPINE1","8838483",1996,"A comparative study of the effects of the hemostatic system of two monophasic gestodene oral contraceptives containing 20 micrograms and 30 micrograms ethinylestradiol.","8838483","Ethinyl Estradiol","Plasminogen Activator Inhibitor 1"]
["Ethinyl Estradiol","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","20590611",2010,"Genistein aglycone improves skin repair in an incisional model of wound healing: a comparison with raloxifene and oestradiol in ovariectomized rats.","20590611","Ethinyl Estradiol","Transforming Growth Factor beta1"]
["Ethinyl Estradiol","Thrombomodulin",1,0,1,0,"THBD","22950374",2012,"Long-term estrogen treatment of mice with a prothrombotic phenotype induces sustained increases in thrombin generation without affecting tissue fibrin deposition.","22950374","Ethinyl Estradiol","Thrombomodulin"]
["Ethinyl Estradiol","Thrombomodulin",1,0,1,1,"THBD","8950781",1996,"Increased levels of activated factor VII and decreased plasma protein S activity and circulating thrombomodulin during use of oral contraceptives.","8950781","Ethinyl Estradiol","Thrombomodulin"]
["Ethinyl Estradiol","Tissue Inhibitor of Metalloproteinase-1",1,0,1,0,"TIMP1","22510229",2012,"Oral contraceptive containing chlormadinone acetate and ethinylestradiol reduces plasma concentrations of matrix metalloproteinase-2 in women with polycystic ovary syndrome.","22510229","Ethinyl Estradiol","Tissue Inhibitor of Metalloproteinase-1"]
["Ethinyl Estradiol","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","17903073",2007,"Combined continuous ethinyl estradiol/norethindrone acetate does not improve forearm blood flow in postmenopausal women at risk for cardiovascular events: a pilot study.","17903073","Ethinyl Estradiol","Vascular Cell Adhesion Molecule-1"]
["Ethinyl Estradiol","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","16735947",2006,"The selective estrogen receptor-beta agonist biochanin A shows vasculoprotective effects without uterotrophic activity.","16735947","Ethinyl Estradiol","Vascular Cell Adhesion Molecule-1"]
["Ethinyl Estradiol","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","22554799",2012,"Drospirenone and levonorgestrel in combination with either 30 or 20 mcg ethinylestradiol reduce soluble adhesion molecules in Brazilian women; cross-sectional study.","22554799","Ethinyl Estradiol","Vascular Cell Adhesion Molecule-1"]
["Ethoxyquin","NF-E2-Related Factor 2",0,0,1,0,"NFE2L2","10816095",2000,"The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin.","10816095","Ethoxyquin","NF-E2-Related Factor 2"]
["Ethylene Chlorohydrin","Matrix Metalloproteinase 9",0,0,1,1,"MMP9","21741468",2011,"Trichloroethanol up-regulates matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in HaCaT cells.","21741468","Ethylene Chlorohydrin","Matrix Metalloproteinase 9"]
["Ethylene Chlorohydrin","Tissue Inhibitor of Metalloproteinase-1",0,0,1,1,"TIMP1","21741468",2011,"Trichloroethanol up-regulates matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in HaCaT cells.","21741468","Ethylene Chlorohydrin","Tissue Inhibitor of Metalloproteinase-1"]
["Ethylene Oxide","Receptor, Epidermal Growth Factor",0,0,0,0,"EGFR","22024195",2012,"EGFR-mediated intracellular delivery of Pc 4 nanoformulation for targeted photodynamic therapy of cancer: in vitro studies.","22024195","Ethylene Oxide","Receptor, Epidermal Growth Factor"]
["Ethylene Oxide","Matrix Metalloproteinase 9",0,0,0,0,"MMP9","23069707",2013,"PEG-co-PCL nanoparticles modified with MMP-2/9 activatable low molecular weight protamine for enhanced targeted glioblastoma therapy.","23069707","Ethylene Oxide","Matrix Metalloproteinase 9"]
["Ethylenethiourea","Chemokine CCL2",0,0,1,0,"CCL2","15729771",2005,"2-Mercaptoimidazoles, a new class of potent CCR2 antagonists.","15729771","Ethylenethiourea","Chemokine CCL2"]
["Fenofibrate","Chemokine CCL2",0,0,1,0,"CCL2","15985720",2005,"Monocyte suppressing action of fenofibrate.","15985720","Fenofibrate","Chemokine CCL2"]
["Fenofibrate","Chemokine CCL2",0,0,1,0,"CCL2","21429719",2012,"Comparison of the effects of n-3 long chain polyunsaturated fatty acids and fenofibrate on markers of inflammation and vascular function, and on the serum lipoprotein profile in overweight and obese subjects.","21429719","Fenofibrate","Chemokine CCL2"]
["Fenofibrate","Chemokine CCL2",0,0,1,0,"CCL2","15772519",2005,"Effect of monthly atorvastatin and fenofibrate treatment on monocyte chemoattractant protein-1 release in patients with primary mixed dyslipidemia.","15772519","Fenofibrate","Chemokine CCL2"]
["Fenofibrate","Chemokine CCL2",0,0,1,0,"CCL2","12756509",2003,"Effects of atorvastatin, simvastatin, and fenofibrate therapy on monocyte chemoattractant protein-1 secretion in patients with hyperlipidemia.","12756509","Fenofibrate","Chemokine CCL2"]
["Fenofibrate","Chemokine CCL2",0,0,1,0,"CCL2","22280018",2013,"Coronary flow velocity reserve is improved by PPAR-? agonist fenofibrate in patients with hypertriglyceridemia.","22280018","Fenofibrate","Chemokine CCL2"]
["Fenofibrate","Chemokine CCL2",0,0,1,0,"CCL2","21270762",2011,"Fenofibrate, a PPAR? agonist, has renoprotective effects in mice by enhancing renal lipolysis.","21270762","Fenofibrate","Chemokine CCL2"]
["Fenofibrate","Chemokine CCL2",0,0,1,0,"CCL2","22228203",2012,"A genome-wide association study of inflammatory biomarker changes in response to fenofibrate treatment in the Genetics of Lipid Lowering Drug and Diet Network.","22228203","Fenofibrate","Chemokine CCL2"]
["Fenofibrate","Chemokine CCL2",0,0,1,1,"CCL2","20360622",2010,"Metabolic and monocyte-suppressing actions of fenofibrate in patients with mixed dyslipidemia and early glucose metabolism disturbances.","20360622","Fenofibrate","Chemokine CCL2"]
["Fenofibrate","Chemokine CCL2",0,0,1,0,"CCL2","19023279",2009,"Effect of fenofibrate on adiponectin and inflammatory biomarkers in metabolic syndrome patients.","19023279","Fenofibrate","Chemokine CCL2"]
["Fenofibrate","Chemokine CCL2",0,0,1,0,"CCL2","18356826",2008,"Effect of peroxisome proliferator-activated receptor-alpha ligands in the interaction between adipocytes and macrophages in obese adipose tissue.","18356826","Fenofibrate","Chemokine CCL2"]
["Fenofibrate","Chemokine CCL2",0,0,1,0,"CCL2","12954370",2003,"Dilazep and fenofibric acid inhibit MCP-1 mRNA expression in glycoxidized LDL-stimulated human endothelial cells.","12954370","Fenofibrate","Chemokine CCL2"]
["Fenofibrate","Antigens, CD40",0,0,1,0,"CD40","14612213",2003,"Efficacy of fenofibrate and simvastatin on endothelial function and inflammatory markers in patients with combined hyperlipidemia: relations with baseline lipid profiles.","14612213","Fenofibrate","Antigens, CD40"]
["Fenofibrate","Antigens, CD40",0,0,1,0,"CD40","15467191",2004,"C-reactive protein-induced expression of CD40-CD40L and the effect of lovastatin and fenofibrate on it in human vascular endothelial cells.","15467191","Fenofibrate","Antigens, CD40"]
["Fenofibrate","Antigens, CD40",0,0,1,0,"CD40","17062332",2006,"Fenofibrate inhibits tumor necrosis factor-alpha-induced expression of CD40 and matrix metalloproteinase in human vascular endothelial cells.","17062332","Fenofibrate","Antigens, CD40"]
["Fenofibrate","Antigens, CD40",0,0,1,0,"CD40","24022598",2014,"The protective effect of fenofibrate against TNF-?-induced CD40 expression through SIRT1-mediated deacetylation of NF-?B in endothelial cells.","24022598","Fenofibrate","Antigens, CD40"]
["Fenofibrate","Antigens, CD40",0,0,1,0,"CD40","23603572",2013,"PPAR? agonist fenofibrate attenuates TNF-?-induced CD40 expression in 3T3-L1 adipocytes via the SIRT1-dependent signaling pathway.","23603572","Fenofibrate","Antigens, CD40"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L900,L900)","v":"Fenofibrate"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M900,M900)","v":"Collagen Type III"},0,0,1,0,"COL3A1",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K900,K900)","v":"12193105"},2002,"Stimulation of peroxisome-proliferator-activated receptor alpha (PPAR alpha) attenuates cardiac fibrosis and endothelin-1 production in pressure-overloaded rat hearts.","12193105","Fenofibrate","Collagen Type III"]
["Fenofibrate","Macrophage Colony-Stimulating Factor",0,0,1,0,"CSF1","12535753",2003,"Insulin resistance and adiposity correlate with acute-phase reaction and soluble cell adhesion molecules in type 2 diabetes.","12535753","Fenofibrate","Macrophage Colony-Stimulating Factor"]
["Fenofibrate","Chemokine CXCL10",0,0,1,0,"CXCL10","17631136",2007,"Fenofibrate represses interleukin-17 and interferon-gamma expression and improves colitis in interleukin-10-deficient mice.","17631136","Fenofibrate","Chemokine CXCL10"]
["Fenofibrate","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","21081159",2011,"Fenofibrate exhibits a high potential to suppress the formation of squamous cell carcinoma in an oral-specific 4-nitroquinoline 1-oxide/arecoline mouse model.","21081159","Fenofibrate","Receptor, Epidermal Growth Factor"]
["Fenofibrate","Receptors, LDL",0,0,1,0,"LDLR","16477380",2006,"Peroxisome proliferator-activated receptor-alpha selective ligand reduces adiposity, improves insulin sensitivity and inhibits atherosclerosis in LDL receptor-deficient mice.","16477380","Fenofibrate","Receptors, LDL"]
["Fenofibrate","Receptors, LDL",0,0,1,0,"LDLR","18852694",2008,"Activation of peroxisome proliferator-activated receptor-alpha in mice induces expression of the hepatic low-density lipoprotein receptor.","18852694","Fenofibrate","Receptors, LDL"]
["Fenofibrate","Receptors, LDL",0,0,1,0,"LDLR","15131765",2004,"Fenofibrate prevents obesity and hypertriglyceridemia in low-density lipoprotein receptor-null mice.","15131765","Fenofibrate","Receptors, LDL"]
["Fenofibrate","Receptors, LDL",0,0,1,0,"LDLR","12593843",2003,"Fenofibrate improves lipid metabolism and obesity in ovariectomized LDL receptor-null mice.","12593843","Fenofibrate","Receptors, LDL"]
["Fenofibrate","Receptors, LDL",0,0,1,0,"LDLR","4088276",1985,"Effects of fenofibrate on receptor-mediated and receptor-independent low density lipoprotein catabolism in hypertriglyceridaemic subjects.","4088276","Fenofibrate","Receptors, LDL"]
["Fenofibrate","Receptors, LDL",0,0,1,0,"LDLR","7590523",1995,"[Anti-atheromatous effects of fenofibrate, a hypolipidemic drug. II: Anti-atheromatous effects are independent of its hypolipidemic effect in hereditary hyperlipidemic rabbits].","7590523","Fenofibrate","Receptors, LDL"]
["Fenofibrate","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","15169608",2004,"Cardiovascular drugs inhibit MMP-9 activity from human THP-1 macrophages.","15169608","Fenofibrate","Matrix Metalloproteinase 9"]
["Fenofibrate","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","10623622",2000,"Activation of PPARalpha or gamma reduces secretion of matrix metalloproteinase 9 but not interleukin 8 from human monocytic THP-1 cells.","10623622","Fenofibrate","Matrix Metalloproteinase 9"]
["Fenofibrate","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","17610352",2007,"Neurological recovery-promoting, anti-inflammatory, and anti-oxidative effects afforded by fenofibrate, a PPAR alpha agonist, in traumatic brain injury.","17610352","Fenofibrate","Matrix Metalloproteinase 9"]
["Fenofibrate","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","17062332",2006,"Fenofibrate inhibits tumor necrosis factor-alpha-induced expression of CD40 and matrix metalloproteinase in human vascular endothelial cells.","17062332","Fenofibrate","Matrix Metalloproteinase 9"]
["Fenofibrate","Matrix Metalloproteinase 9",0,0,1,1,"MMP9","17306985",2007,"Preventive effects of fenofibrate on insulin resistance, hyperglycaemia, visceral fat accumulation in NIH mice induced by small-dose streptozotocin and lard.","17306985","Fenofibrate","Matrix Metalloproteinase 9"]
["Fenofibrate","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","15467191",2004,"C-reactive protein-induced expression of CD40-CD40L and the effect of lovastatin and fenofibrate on it in human vascular endothelial cells.","15467191","Fenofibrate","Matrix Metalloproteinase 9"]
["Fenofibrate","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","17353509",2007,"Peroxisome proliferator-activated receptor alpha-independent actions of fenofibrate exacerbates left ventricular dilation and fibrosis in chronic pressure overload.","17353509","Fenofibrate","Matrix Metalloproteinase 9"]
["Fenofibrate","NF-E2-Related Factor 2",0,0,1,1,"NFE2L2","18775883",2008,"Role of Nrf2 and oxidative stress on fenofibrate-induced hepatocarcinogenesis in rats.","18775883","Fenofibrate","NF-E2-Related Factor 2"]
["Fenofibrate","Serum Amyloid A Protein",0,0,1,0,"SAA1","12115201",2002,"Fenofibrate inhibits reactive amyloidosis in mice.","12115201","Fenofibrate","Serum Amyloid A Protein"]
["Fenofibrate","Serum Amyloid A Protein",0,0,1,0,"SAA1","14764586",2004,"Global suppression of IL-6-induced acute phase response gene expression after chronic in vivo treatment with the peroxisome proliferator-activated receptor-alpha activator fenofibrate.","14764586","Fenofibrate","Serum Amyloid A Protein"]
["Fenofibrate","Serum Amyloid A Protein",0,0,1,0,"SAA1","11798191",2002,"Microarray analysis of gene expression changes in mouse liver induced by peroxisome proliferator- activated receptor alpha agonists.","11798191","Fenofibrate","Serum Amyloid A Protein"]
["Fenofibrate","E-Selectin",0,0,1,0,"SELE","15189781",2004,"Effect of simvastatin and fenofibrate on endothelium in Type 2 diabetes.","15189781","Fenofibrate","E-Selectin"]
["Fenofibrate","E-Selectin",0,0,1,0,"SELE","21429719",2012,"Comparison of the effects of n-3 long chain polyunsaturated fatty acids and fenofibrate on markers of inflammation and vascular function, and on the serum lipoprotein profile in overweight and obese subjects.","21429719","Fenofibrate","E-Selectin"]
["Fenofibrate","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","17085865",2006,"Extralipid effects of micronized fenofibrate in dyslipidemic patients.","17085865","Fenofibrate","Plasminogen Activator Inhibitor 1"]
["Fenofibrate","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","23563040",2013,"Effect of metformin on selected parameters of hemostasis in fenofibrate-treated patients with impaired glucose tolerance.","23563040","Fenofibrate","Plasminogen Activator Inhibitor 1"]
["Fenofibrate","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","19435959",2009,"Pleiotropic action of short-term metformin and fenofibrate treatment, combined with lifestyle intervention, in type 2 diabetic patients with mixed dyslipidemia.","19435959","Fenofibrate","Plasminogen Activator Inhibitor 1"]
["Fenofibrate","Plasminogen Activator Inhibitor 1",0,0,1,1,"SERPINE1","21273667",2010,"Hemostatic effects of fenofibrate in patients with mixed dyslipidemia and impaired fasting glucose.","21273667","Fenofibrate","Plasminogen Activator Inhibitor 1"]
["Fenofibrate","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","17179821",2007,"The alteration of plasminogen activator inhibitor-1 expression by linoleic acid and fenofibrate in HepG2 cells.","17179821","Fenofibrate","Plasminogen Activator Inhibitor 1"]
["Fenofibrate","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","15469859",2004,"Fenofibrate inhibits thrombogenic and fibrinolytic factors expression in adipose tissue of atherosclerotic rabbits.","15469859","Fenofibrate","Plasminogen Activator Inhibitor 1"]
["Fenofibrate","Plasminogen Activator Inhibitor 1",0,0,1,1,"SERPINE1","20587704",2010,"Pleiotropic effects of atorvastatin and fenofibrate in metabolic syndrome and different types of pre-diabetes.","20587704","Fenofibrate","Plasminogen Activator Inhibitor 1"]
["Fenofibrate","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","20824151",2010,"Treatment with pravastatin and fenofibrate improves atherogenic lipid profiles but not inflammatory markers in ACTG 5087.","20824151","Fenofibrate","Plasminogen Activator Inhibitor 1"]
["Fenofibrate","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","12006402",2002,"Induction of plasminogen activator inhibitor-1 in endothelial cells by basic fibroblast growth factor and its modulation by fibric acid.","12006402","Fenofibrate","Plasminogen Activator Inhibitor 1"]
["Fenofibrate","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","16624630",2006,"Renoprotective effects of fenofibrate in diabetic rats are achieved by suppressing kidney plasminogen activator inhibitor-1.","16624630","Fenofibrate","Plasminogen Activator Inhibitor 1"]
["Fenofibrate","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","16850744",2006,"Inhibitory effects of fenofibrate on plasminogen activator inhibitor-1 expression in human endothelial cells.","16850744","Fenofibrate","Plasminogen Activator Inhibitor 1"]
["Fenofibrate","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","18465086",2008,"Improvement of inflammatory responses associated with NF-kappa B pathway in kidneys from diabetic rats.","18465086","Fenofibrate","Plasminogen Activator Inhibitor 1"]
["Fenofibrate","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","12666442",2002,"[Pleiotropic effects of micronized fenofibrate in patients with combined hyperlipidemia].","12666442","Fenofibrate","Plasminogen Activator Inhibitor 1"]
["Fenofibrate","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","11770837",2001,"Effects of fibrates on plasma prothrombotic activity in patients with type IIb dyslipidemia.","11770837","Fenofibrate","Plasminogen Activator Inhibitor 1"]
["Fenofibrate","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","17931611",2008,"Inhibition of plasminogen activator inhibitor type-1 expression in HepG2 cells by fenofibrate may be associated with Smad signaling.","17931611","Fenofibrate","Plasminogen Activator Inhibitor 1"]
["Fenofibrate","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","19593819",2009,"Fenofibrate differentially regulates plasminogen activator inhibitor-1 gene expression via adenosine monophosphate-activated protein kinase-dependent induction of orphan nuclear receptor small heterodimer partner.","19593819","Fenofibrate","Plasminogen Activator Inhibitor 1"]
["Fenofibrate","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","15189781",2004,"Effect of simvastatin and fenofibrate on endothelium in Type 2 diabetes.","15189781","Fenofibrate","Plasminogen Activator Inhibitor 1"]
["Fenofibrate","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","19492148",2009,"Inhibition by fibrates of plasminogen activator inhibitor type-1 expression in human adipocytes and preadipocytes.","19492148","Fenofibrate","Plasminogen Activator Inhibitor 1"]
["Fenofibrate","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","9869165",1998,"Fibrate-modulated expression of fibrinogen, plasminogen activator inhibitor-1 and apolipoprotein A-I in cultured cynomolgus monkey hepatocytes -- role of the peroxisome proliferator-activated receptor-alpha.","9869165","Fenofibrate","Plasminogen Activator Inhibitor 1"]
["Fenofibrate","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","24392081",2014,"Therapeutic effects of fenofibrate on diabetic peripheral neuropathy by improving endothelial and neural survival in db/db mice.","24392081","Fenofibrate","Transforming Growth Factor beta1"]
["Fenofibrate","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","16624630",2006,"Renoprotective effects of fenofibrate in diabetic rats are achieved by suppressing kidney plasminogen activator inhibitor-1.","16624630","Fenofibrate","Transforming Growth Factor beta1"]
["Fenofibrate","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","20404057",2010,"Fenofibrate attenuates tubulointerstitial fibrosis and inflammation through suppression of nuclear factor-?B and transforming growth factor-?1/Smad3 in diabetic nephropathy.","20404057","Fenofibrate","Transforming Growth Factor beta1"]
["Fenofibrate","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","14871557",2004,"PPAR alpha activator fenofibrate inhibits myocardial inflammation and fibrosis in angiotensin II-infused rats.","14871557","Fenofibrate","Transforming Growth Factor beta1"]
["Fenofibrate","Thrombomodulin",0,0,1,0,"THBD","16343039",2006,"Folate co-administration improves the effectiveness of fenofibrate to decrease the lipoprotein oxidation and endothelial dysfunction surrogates.","16343039","Fenofibrate","Thrombomodulin"]
["Fenofibrate","Thrombomodulin",0,0,1,0,"THBD","17869327",2008,"Modulation of endothelial cell thrombomodulin by PPAR ligands--variation according to environment.","17869327","Fenofibrate","Thrombomodulin"]
["Fenofibrate","Tissue Inhibitor of Metalloproteinase-1",0,0,1,0,"TIMP1","15169608",2004,"Cardiovascular drugs inhibit MMP-9 activity from human THP-1 macrophages.","15169608","Fenofibrate","Tissue Inhibitor of Metalloproteinase-1"]
["Fenofibrate","Tissue Inhibitor of Metalloproteinase-1",0,0,1,0,"TIMP1","20511708",2010,"Modulation of LPS-mediated inflammation by fenofibrate via the TRIF-dependent TLR4 signaling pathway in vascular smooth muscle cells.","20511708","Fenofibrate","Tissue Inhibitor of Metalloproteinase-1"]
["Fenofibrate","Tissue Inhibitor of Metalloproteinase-1",0,0,1,0,"TIMP1","15458690",2004,"Comparative effects of statin and fibrate on nitric oxide bioactivity and matrix metalloproteinase in hyperlipidemia.","15458690","Fenofibrate","Tissue Inhibitor of Metalloproteinase-1"]
["Fenofibrate","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","19531154",2009,"Fenofibrate attenuates endothelial monocyte adhesion in chronic heart failure: an in vitro study.","19531154","Fenofibrate","Vascular Cell Adhesion Molecule-1"]
["Fenofibrate","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","17483155",2007,"Fenofibrate therapy ameliorates fasting and postprandial lipoproteinemia, oxidative stress, and the inflammatory response in subjects with hypertriglyceridemia and the metabolic syndrome.","17483155","Fenofibrate","Vascular Cell Adhesion Molecule-1"]
["Fenofibrate","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","12535753",2003,"Insulin resistance and adiposity correlate with acute-phase reaction and soluble cell adhesion molecules in type 2 diabetes.","12535753","Fenofibrate","Vascular Cell Adhesion Molecule-1"]
["Fenofibrate","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","19023279",2009,"Effect of fenofibrate on adiponectin and inflammatory biomarkers in metabolic syndrome patients.","19023279","Fenofibrate","Vascular Cell Adhesion Molecule-1"]
["Fenofibrate","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","16806263",2006,"Attenuation of cardiac dysfunction by a PPAR-alpha agonist is associated with down-regulation of redox-regulated transcription factors.","16806263","Fenofibrate","Vascular Cell Adhesion Molecule-1"]
["Fenofibrate","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","17319106",2005,"Vascular endothelium as a target of beraprost sodium and fenofibrate for antiatherosclerotic therapy in type 2 diabetes mellitus.","17319106","Fenofibrate","Vascular Cell Adhesion Molecule-1"]
["Fenofibrate","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","21757154",2011,"Short-term fenofibrate treatment reduces elevated plasma Lp-PLA2 mass and sVCAM-1 levels in a subcohort of hypertriglyceridemic GOLDN participants.","21757154","Fenofibrate","Vascular Cell Adhesion Molecule-1"]
["Fenofibrate","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","18159007",2007,"[Impact of fenofibrate on NO and endothelial VCAM-1 expression in hyperlipidemic rats].","18159007","Fenofibrate","Vascular Cell Adhesion Molecule-1"]
["Fenofibrate","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","18294485",2008,"Fenofibrate reduces lipoprotein associated phospholipase A2 mass and oxidative lipids in hypertriglyceridemic subjects with the metabolic syndrome.","18294485","Fenofibrate","Vascular Cell Adhesion Molecule-1"]
["Fenofibrate","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","12867511",2003,"Peroxisome proliferator-activated receptor-alpha activation as a mechanism of preventive neuroprotection induced by chronic fenofibrate treatment.","12867511","Fenofibrate","Vascular Cell Adhesion Molecule-1"]
["Flutamide","Chemokine CCL2",1,1,1,0,"CCL2","16895975",2006,"Effects of 17beta-estradiol and flutamide on inflammatory response and distant organ damage following trauma-hemorrhage in metestrus females.","16895975","Flutamide","Chemokine CCL2"]
["Flutamide","Receptor, Epidermal Growth Factor",1,1,1,0,"EGFR","12414626",2002,"Activation of mitogen-activated protein kinase pathway by the antiandrogen hydroxyflutamide in androgen receptor-negative prostate cancer cells.","12414626","Flutamide","Receptor, Epidermal Growth Factor"]
["Flutamide","Receptor, Epidermal Growth Factor",1,1,1,0,"EGFR","21729454",2011,"Structural changes and immunohistochemical localisation of epidermal growth factor receptor in the true vocal fold of female albino rats administered anabolic, androgenic steroids, and effects of anti-androgen therapy.","21729454","Flutamide","Receptor, Epidermal Growth Factor"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L964,L964)","v":"Flutamide"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M964,M964)","v":"Receptor, Epidermal Growth Factor"},1,1,1,0,"EGFR",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K964,K964)","v":"7784269"},1995,"Androgenic and antiandrogenic control on epidermal growth factor, epidermal growth factor receptor, and androgen receptor expression in human prostate cancer cell line LNCaP.","7784269","Flutamide","Receptor, Epidermal Growth Factor"]
["Flutamide","Receptors, Thromboxane A2, Prostaglandin H2",1,1,1,0,"TBXA2R","15820970",2005,"Castration reduces platelet thromboxane A2 receptor density and aggregability.","15820970","Flutamide","Receptors, Thromboxane A2, Prostaglandin H2"]
["Flutamide","Receptors, Thromboxane A2, Prostaglandin H2",1,1,1,0,"TBXA2R","17110800",2006,"The effect of flutamide on systemic and renal hemodynamics in Zucker diabetic rats: paradoxic renal vasodilator response to endothelin-1 and TXA2 receptor activation in female sex.","17110800","Flutamide","Receptors, Thromboxane A2, Prostaglandin H2"]
["Flutamide","Transforming Growth Factor beta1",1,1,1,0,"TGFB1","22276587",2012,"Topical androgen antagonism promotes cutaneous wound healing without systemic androgen deprivation by blocking ?-catenin nuclear translocation and cross-talk with TGF-? signaling in keratinocytes.","22276587","Flutamide","Transforming Growth Factor beta1"]
["Genistein","Chemokine CCL2",0,0,1,0,"CCL2","23291378",2013,"Genistein inhibits ox-LDL-induced VCAM-1, ICAM-1 and MCP-1 expression of HUVECs through heme oxygenase-1.","23291378","Genistein","Chemokine CCL2"]
["Genistein","Chemokine CCL2",0,0,1,0,"CCL2","23737649",2013,"Protective effect of short-term genistein supplementation on the early stage in diabetes-induced renal damage.","23737649","Genistein","Chemokine CCL2"]
["Genistein","Chemokine CCL2",0,0,1,0,"CCL2","14980449",2004,"Sulfation of genistein alters its antioxidant properties and its effect on platelet aggregation and monocyte and endothelial function.","14980449","Genistein","Chemokine CCL2"]
["Genistein","Chemokine CCL2",0,0,1,0,"CCL2","12720581",2003,"Effect of genistein and daidzein on platelet aggregation and monocyte and endothelial function.","12720581","Genistein","Chemokine CCL2"]
["Genistein","Collagen Type III",0,0,1,0,"COL3A1","23274713",2013,"Protective effect of genistein isolated from Hydrocotyle sibthorpioides on hepatic injury and fibrosis induced by chronic alcohol in rats.","23274713","Genistein","Collagen Type III"]
["Genistein","Macrophage Colony-Stimulating Factor",0,0,1,1,"CSF1","15925024",2005,"Myelotoxicity in genistein-, nonylphenol-, methoxychlor-, vinclozolin- or ethinyl estradiol-exposed F1 generations of Sprague-Dawley rats following developmental and adult exposures.","15925024","Genistein","Macrophage Colony-Stimulating Factor"]
["Genistein","Macrophage Colony-Stimulating Factor",0,0,1,0,"CSF1","17295206",2007,"Genistein and zinc synergistically stimulate apoptotic cell death and suppress RANKL signaling-related gene expression in osteoclastic cells.","17295206","Genistein","Macrophage Colony-Stimulating Factor"]
["Genistein","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","21603581",2011,"Genistein increases epidermal growth factor receptor signaling and promotes tumor progression in advanced human prostate cancer.","21603581","Genistein","Receptor, Epidermal Growth Factor"]
["Genistein","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","21111822",2011,"Genistein enhances relaxation of the spontaneously hypertensive rat aorta by transactivation of epidermal growth factor receptor following binding to membrane estrogen receptors-? and activation of a G protein-coupled, endothelial nitric oxide synthase-dependent pathway.","21111822","Genistein","Receptor, Epidermal Growth Factor"]
["Genistein","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","16954323",2006,"In vitro metacestodicidal activities of genistein and other isoflavones against Echinococcus multilocularis and Echinococcus granulosus.","16954323","Genistein","Receptor, Epidermal Growth Factor"]
["Genistein","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","20138837",2010,"Lipid raft cholesterol and genistein inhibit the cell viability of prostate cancer cells via the partial contribution of EGFR-Akt/p70S6k pathway and down-regulation of androgen receptor.","20138837","Genistein","Receptor, Epidermal Growth Factor"]
["Genistein","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","15852031",2005,"Epidermal growth factor receptor tyrosine kinase-mediated signalling contributes to diabetes-induced vascular dysfunction in the mesenteric bed.","15852031","Genistein","Receptor, Epidermal Growth Factor"]
["Genistein","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","19959278",2010,"Combined cetuximab and genistein treatment shows additive anti-cancer effect on oral squamous cell carcinoma.","19959278","Genistein","Receptor, Epidermal Growth Factor"]
["Genistein","Receptor, Epidermal Growth Factor",0,0,1,1,"EGFR","11217368",2001,"Tyrosine kinase inhibitors against EGF receptor-positive malignancies.","11217368","Genistein","Receptor, Epidermal Growth Factor"]
["Genistein","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","19288574",2009,"Genistein enhances the effect of epidermal growth factor receptor tyrosine kinase inhibitors and inhibits nuclear factor kappa B in nonsmall cell lung cancer cell lines.","19288574","Genistein","Receptor, Epidermal Growth Factor"]
["Genistein","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","11170137",2001,"Detrimental effect of cancer preventive phytochemicals silymarin, genistein and epigallocatechin 3-gallate on epigenetic events in human prostate carcinoma DU145 cells.","11170137","Genistein","Receptor, Epidermal Growth Factor"]
["Genistein","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","1658553",1991,"Use and specificity of genistein as inhibitor of protein-tyrosine kinases.","1658553","Genistein","Receptor, Epidermal Growth Factor"]
["Genistein","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","2153378",1990,"Mechanisms of action in NIH-3T3 cells of genistein, an inhibitor of EGF receptor tyrosine kinase activity.","2153378","Genistein","Receptor, Epidermal Growth Factor"]
["Genistein","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","15491342",2004,"Epidermal growth factor stimulates urokinase-type plasminogen activator expression in human gingival fibroblasts. Possible modulation by genistein and curcumin.","15491342","Genistein","Receptor, Epidermal Growth Factor"]
["Genistein","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","12189189",2002,"Genistein action in the prepubertal mammary gland in a chemoprevention model.","12189189","Genistein","Receptor, Epidermal Growth Factor"]
["Genistein","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","21570948",2011,"Genistein and tyrphostin AG556 inhibit inwardly-rectifying Kir2.1 channels expressed in HEK 293 cells via protein tyrosine kinase inhibition.","21570948","Genistein","Receptor, Epidermal Growth Factor"]
["Genistein","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","10774791",2000,"EGF-genistein inhibits neointimal hyperplasia after vascular injury in an experimental restenosis model.","10774791","Genistein","Receptor, Epidermal Growth Factor"]
["Genistein","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","19149197",2008,"[Molecular docking of epidermal growth factor receptor tyramine kinase domain and its inhibitor genistein].","19149197","Genistein","Receptor, Epidermal Growth Factor"]
["Genistein","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","24456004",2014,"Epigallocatechin 3-O-gallate induces 67 kDa laminin receptor-mediated cell death accompanied by downregulation of ErbB proteins and altered lipid raft clustering in mammary and epidermoid carcinoma cells.","24456004","Genistein","Receptor, Epidermal Growth Factor"]
["Genistein","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","17079479",2006,"Potentiation of the effect of erlotinib by genistein in pancreatic cancer: the role of Akt and nuclear factor-kappaB.","17079479","Genistein","Receptor, Epidermal Growth Factor"]
["Genistein","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","2548712",1989,"Inhibitory effects of the tyrosine kinase inhibitor genistein on mammalian DNA topoisomerase II.","2548712","Genistein","Receptor, Epidermal Growth Factor"]
["Genistein","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","18155830",2008,"Antibodies directed against L1-CAM synergize with Genistein in inhibiting growth and survival pathways in SKOV3ip human ovarian cancer cells.","18155830","Genistein","Receptor, Epidermal Growth Factor"]
["Genistein","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","22293631",2012,"A phase 2 cancer chemoprevention biomarker trial of isoflavone G-2535 (genistein) in presurgical bladder cancer patients.","22293631","Genistein","Receptor, Epidermal Growth Factor"]
["Genistein","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","10845426",2000,"Genistein regulation of transforming growth factor-alpha, epidermal growth factor (EGF), and EGF receptor expression in the rat uterus and vagina.","10845426","Genistein","Receptor, Epidermal Growth Factor"]
["Genistein","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","10837323",2000,"Protection against breast cancer with genistein: a component of soy.","10837323","Genistein","Receptor, Epidermal Growth Factor"]
["Genistein","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","12840195",2003,"Dietary diethylstilbestrol but not genistein adversely affects rat testicular development.","12840195","Genistein","Receptor, Epidermal Growth Factor"]
["Genistein","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","19665144",2010,"Effects of epidermal growth factor receptor inhibitor genistein on proliferative cholangitis in rats.","19665144","Genistein","Receptor, Epidermal Growth Factor"]
["Genistein","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","22160570",2012,"Synergistic inhibitory effects by the combination of gefitinib and genistein on NSCLC with acquired drug-resistance in vitro and in vivo.","22160570","Genistein","Receptor, Epidermal Growth Factor"]
["Genistein","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","12894229",2003,"Oestrogens and selective oestrogen receptor (ER) modulators regulate EGF receptor gene expression through human ER alpha and beta subtypes via an Sp1 site.","12894229","Genistein","Receptor, Epidermal Growth Factor"]
["Genistein","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","19272193",2009,"Genistein-mediated inhibition of glycosaminoglycan synthesis, which corrects storage in cells of patients suffering from mucopolysaccharidoses, acts by influencing an epidermal growth factor-dependent pathway.","19272193","Genistein","Receptor, Epidermal Growth Factor"]
["Genistein","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","18635334",2008,"IGF-I- and EGF-dependent DNA synthesis of porcine myoblasts is influenced by the dietary isoflavones genistein and daidzein.","18635334","Genistein","Receptor, Epidermal Growth Factor"]
["Genistein","Receptor, Epidermal Growth Factor",0,0,1,1,"EGFR","19059320",2009,"Genistein decreases androgen biosynthesis in rat Leydig cells by interference with luteinizing hormone-dependent signaling.","19059320","Genistein","Receptor, Epidermal Growth Factor"]
["Genistein","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","15257099",2004,"Genistein-induced changes in gene expression in Panc 1 cells at physiological concentrations of genistein.","15257099","Genistein","Receptor, Epidermal Growth Factor"]
["Genistein","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","15634453",2004,"[The effects of genistein on epidermal growth factor receptor mediated signal transduction pathway in human ovarian carcinoma cells lines SKOV3 and its xenograft in nude mice].","15634453","Genistein","Receptor, Epidermal Growth Factor"]
["Genistein","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","16670689",2006,"Genistein-mediated inhibition of glycosaminoglycan synthesis as a basis for gene expression-targeted isoflavone therapy for mucopolysaccharidoses.","16670689","Genistein","Receptor, Epidermal Growth Factor"]
["Genistein","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","3106339",1987,"Genistein, a specific inhibitor of tyrosine-specific protein kinases.","3106339","Genistein","Receptor, Epidermal Growth Factor"]
["Genistein","Receptor, Epidermal Growth Factor",0,0,1,1,"EGFR","15778002",2005,"Dynamic profiling of estrogen receptor and epidermal growth factor signaling in the uteri of genistein- and estrogen-treated rats.","15778002","Genistein","Receptor, Epidermal Growth Factor"]
["Genistein","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","8201603",1994,"Structural studies on bioactive compounds. 23. Synthesis of polyhydroxylated 2-phenylbenzothiazoles and a comparison of their cytotoxicities and pharmacological properties with genistein and quercetin.","8201603","Genistein","Receptor, Epidermal Growth Factor"]
["Genistein","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","9666817",1998,"Genistein and erbstatin inhibition of normal mammary epithelial cell proliferation is associated with EGF-receptor down-regulation.","9666817","Genistein","Receptor, Epidermal Growth Factor"]
["Genistein","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","9607569",1998,"In vivo toxicity, pharmacokinetics, and anticancer activity of Genistein linked to recombinant human epidermal growth factor.","9607569","Genistein","Receptor, Epidermal Growth Factor"]
["Genistein","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","8074476",1994,"Antiproliferative effect of genistein and adriamycin against estrogen-dependent and -independent human breast carcinoma cell lines.","8074476","Genistein","Receptor, Epidermal Growth Factor"]
["Genistein","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","7794275",1995,"Potent inhibition of breast cancer cell lines by the isoflavonoid kievitone: comparison with genistein.","7794275","Genistein","Receptor, Epidermal Growth Factor"]
["Genistein","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","8497428",1993,"Genistein and biochanin A inhibit the growth of human prostate cancer cells but not epidermal growth factor receptor tyrosine autophosphorylation.","8497428","Genistein","Receptor, Epidermal Growth Factor"]
["Genistein","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","9600350",1998,"Inhibition of ultraviolet B (UVB)-induced c-fos and c-jun expression in vivo by a tyrosine kinase inhibitor genistein.","9600350","Genistein","Receptor, Epidermal Growth Factor"]
["Genistein","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","9563884",1998,"Cytotoxic activity of epidermal growth factor-genistein against breast cancer cells.","9563884","Genistein","Receptor, Epidermal Growth Factor"]
["Genistein","Receptor, Epidermal Growth Factor",0,0,1,1,"EGFR","9721067",1998,"Genistein, a component of soy, inhibits the expression of the EGF and ErbB2/Neu receptors in the rat dorsolateral prostate.","9721067","Genistein","Receptor, Epidermal Growth Factor"]
["Genistein","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","9309250",1997,"Genistein analogues: effects on epidermal growth factor receptor tyrosine kinase and on stress-activated pathways.","9309250","Genistein","Receptor, Epidermal Growth Factor"]
["Genistein","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","8702388",1996,"Genistein, a tyrosine kinase inhibitor, reduces EGF-induced EGF receptor internalization and degradation in human hepatoma HepG2 cells.","8702388","Genistein","Receptor, Epidermal Growth Factor"]
["Genistein","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","8971836",1997,"Inhibition of epidermal growth factor receptor-associated tyrosine kinase blocks glioblastoma invasion of the brain.","8971836","Genistein","Receptor, Epidermal Growth Factor"]
["Genistein","Receptor, Epidermal Growth Factor",0,0,1,1,"EGFR","8297123",1993,"Antiproliferative effect of tyrosine kinase inhibitors in epidermal growth factor-stimulated growth of human gastric cancer cells.","8297123","Genistein","Receptor, Epidermal Growth Factor"]
["Genistein","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","9833772",1998,"Inhibition of human bladder cancer cell motility by genistein is dependent on epidermal growth factor receptor but not p21ras gene expression.","9833772","Genistein","Receptor, Epidermal Growth Factor"]
["Genistein","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","9863635",1998,"Prepubertal genistein treatment modulates TGF-alpha, EGF and EGF-receptor mRNAs and proteins in the rat mammary gland.","9863635","Genistein","Receptor, Epidermal Growth Factor"]
["Genistein","Receptors, LDL",0,0,1,0,"LDLR","18621112",2008,"Early induction of LDL receptor gene expression by genistein in DLD-1 colon cancer cell line.","18621112","Genistein","Receptors, LDL"]
["Genistein","Receptors, LDL",0,0,1,0,"LDLR","19011673",2008,"Genistein inhibits the development of atherosclerosis via inhibiting NF-kappaB and VCAM-1 expression in LDLR knockout mice.","19011673","Genistein","Receptors, LDL"]
["Genistein","Matrix Metalloproteinase 1",0,0,1,0,"MMP1","21288455",2011,"[Anti-angiogenic effects of genistein on synovium in a rat model of type II collagen-induced arthritis].","21288455","Genistein","Matrix Metalloproteinase 1"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L1028,L1028)","v":"Genistein"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M1028,M1028)","v":"Matrix Metalloproteinase 9"},0,0,1,0,"MMP9",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K1028,K1028)","v":"16598420"},2006,"Inhibition of matrix degrading enzymes and invasion in human glioblastoma (U87MG) cells by isoflavones.","16598420","Genistein","Matrix Metalloproteinase 9"]
["Genistein","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","12576960",2003,"Time course for inhibition of lipopolysaccharide-induced lung injury by genistein: relationship to alteration in nuclear factor-kappaB activity and inflammatory agents.","12576960","Genistein","Matrix Metalloproteinase 9"]
["Genistein","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","16651437",2006,"Antitumor and antimetastatic activities of docetaxel are enhanced by genistein through regulation of osteoprotegerin/receptor activator of nuclear factor-kappaB (RANK)/RANK ligand/MMP-9 signaling in prostate cancer.","16651437","Genistein","Matrix Metalloproteinase 9"]
["Genistein","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","21288455",2011,"[Anti-angiogenic effects of genistein on synovium in a rat model of type II collagen-induced arthritis].","21288455","Genistein","Matrix Metalloproteinase 9"]
["Genistein","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","10389972",1999,"A comparative study of the effects of genistein and 2-methoxyestradiol on the proteolytic balance and tumour cell proliferation.","10389972","Genistein","Matrix Metalloproteinase 9"]
["Genistein","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","22884883",2012,"Inhibitory effect of genistein on the invasive potential of human cervical cancer cells via modulation of matrix metalloproteinase-9 and tissue inhibitors of matrix metalloproteinase-1 expression.","22884883","Genistein","Matrix Metalloproteinase 9"]
["Genistein","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","21792602",2012,"Genistein inhibit cytokines or growth factor-induced proliferation and transformation phenotype in fibroblast-like synoviocytes of rheumatoid arthritis.","21792602","Genistein","Matrix Metalloproteinase 9"]
["Genistein","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","21827449",2012,"Genistein aglycone, a soy-derived isoflavone, improves skin changes induced by ovariectomy in rats.","21827449","Genistein","Matrix Metalloproteinase 9"]
["Genistein","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","11778268",2000,"[Genistein exerts multiple suppressive effects on human breast carcinoma cells].","11778268","Genistein","Matrix Metalloproteinase 9"]
["Genistein","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","11751518",2001,"Genistein elicits pleiotropic molecular effects on head and neck cancer cells.","11751518","Genistein","Matrix Metalloproteinase 9"]
["Genistein","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","15323430",2004,"[Effect of genistein on expression of angiogenesis related factors in HER-2/neu-overexpressing breast cancer cells].","15323430","Genistein","Matrix Metalloproteinase 9"]
["Genistein","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","11751189",2001,"Genistein prevents nuclear factor-kappa B activation and acute lung injury induced by lipopolysaccharide.","11751189","Genistein","Matrix Metalloproteinase 9"]
["Genistein","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","12903810",1999,"Effects of genistein on invasion and matrix metalloproteinase activities of HT1080 human fibrosarcoma cells.","12903810","Genistein","Matrix Metalloproteinase 9"]
["Genistein","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","20354770",2010,"FoxM1 is a novel target of a natural agent in pancreatic cancer.","20354770","Genistein","Matrix Metalloproteinase 9"]
["Genistein","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","11776827",1999,"[Protein tyrosine kinase inhibitor genistein suppresses in vitro invasion of HT1080 human fibrosarcoma cells].","11776827","Genistein","Matrix Metalloproteinase 9"]
["Genistein","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","9673352",1998,"Genistein inhibits both constitutive and EGF-stimulated invasion in ER-negative human breast carcinoma cell lines.","9673352","Genistein","Matrix Metalloproteinase 9"]
["Genistein","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","9809990",1998,"Genistein exerts multiple suppressive effects on human breast carcinoma cells.","9809990","Genistein","Matrix Metalloproteinase 9"]
["Genistein","NF-E2-Related Factor 2",0,0,1,0,"NFE2L2","22272764",2012,"Flavonoids protect cerebrovascular endothelial cells through Nrf2 and PI3K from ?-amyloid peptide-induced oxidative damage.","22272764","Genistein","NF-E2-Related Factor 2"]
["Genistein","NF-E2-Related Factor 2",0,0,1,0,"NFE2L2","23291378",2013,"Genistein inhibits ox-LDL-induced VCAM-1, ICAM-1 and MCP-1 expression of HUVECs through heme oxygenase-1.","23291378","Genistein","NF-E2-Related Factor 2"]
["Genistein","NF-E2-Related Factor 2",0,0,1,0,"NFE2L2","23536494",2013,"Genistein attenuates ischemic oxidative damage and behavioral deficits via eNOS/Nrf2/HO-1 signaling.","23536494","Genistein","NF-E2-Related Factor 2"]
["Genistein","NF-E2-Related Factor 2",0,0,1,0,"NFE2L2","22716961",2013,"Activation of nuclear factor erythroid 2-related factor 2 and PPAR? plays a role in the genistein-mediated attenuation of oxidative stress-induced endothelial cell injury.","22716961","Genistein","NF-E2-Related Factor 2"]
["Genistein","NF-E2-Related Factor 2",0,0,1,0,"NFE2L2","16780800",2006,"Activation of glutathione peroxidase via Nrf1 mediates genistein's protection against oxidative endothelial cell injury.","16780800","Genistein","NF-E2-Related Factor 2"]
["Genistein","NF-E2-Related Factor 2",0,0,1,0,"NFE2L2","23255485",2013,"Dietary flavonoid genistein induces Nrf2 and phase II detoxification gene expression via ERKs and PKC pathways and protects against oxidative stress in Caco-2 cells.","23255485","Genistein","NF-E2-Related Factor 2"]
["Genistein","NF-E2-Related Factor 2",0,0,1,0,"NFE2L2","20362658",2010,"Genistein as a neuroprotective antioxidant attenuates redox imbalance induced by beta-amyloid peptides 25-35 in PC12 cells.","20362658","Genistein","NF-E2-Related Factor 2"]
["Genistein","Receptors, Urokinase Plasminogen Activator",0,0,1,0,"PLAUR","16689831",2006,"Urokinase plasminogen activator receptor (uPAR) expression is reduced by tyrosine kinase inhibitors.","16689831","Genistein","Receptors, Urokinase Plasminogen Activator"]
["Genistein","Receptors, Urokinase Plasminogen Activator",0,0,1,0,"PLAUR","16598420",2006,"Inhibition of matrix degrading enzymes and invasion in human glioblastoma (U87MG) cells by isoflavones.","16598420","Genistein","Receptors, Urokinase Plasminogen Activator"]
["Genistein","E-Selectin",0,0,1,0,"SELE","15879919",2005,"Effects of soy isoflavones on endothelial function in healthy postmenopausal women.","15879919","Genistein","E-Selectin"]
["Genistein","E-Selectin",0,0,1,0,"SELE","19248247",2009,"7-Difluoromethyl-5,4'-dimethoxygenistein inhibits oxidative stress induced adhesion between endothelial cells and monocytes via NF-kappaB.","19248247","Genistein","E-Selectin"]
["Genistein","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","20838740",2010,"Genistein alters coagulation gene expression in ovariectomised rats treated with phytoestrogens.","20838740","Genistein","Plasminogen Activator Inhibitor 1"]
["Genistein","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","10790891",2000,"Expression of nerve growth factor-induced type 1 plasminogen activator inhibitor (PAI-1) mRNA is inhibited by genistein and wortmannin.","10790891","Genistein","Plasminogen Activator Inhibitor 1"]
["Genistein","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","18410952",2008,"Haemostatic effects of phytoestrogen genistein in postmenopausal women.","18410952","Genistein","Plasminogen Activator Inhibitor 1"]
["Genistein","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","10764687",2000,"Hypoxia induces transcription of the plasminogen activator inhibitor-1 gene through genistein-sensitive tyrosine kinase pathways in vascular endothelial cells.","10764687","Genistein","Plasminogen Activator Inhibitor 1"]
["Genistein","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","9893662",1998,"Modulation of the proteolytic balance plasminogen activator/plasminogen activator inhibitor by enhanced N-myc oncogene expression or application of genistein.","9893662","Genistein","Plasminogen Activator Inhibitor 1"]
["Genistein","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","7949170",1994,"Genistein reduces tumor necrosis factor alpha-induced plasminogen activator inhibitor-1 transcription but not urokinase expression in human endothelial cells.","7949170","Genistein","Plasminogen Activator Inhibitor 1"]
["Genistein","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","24129183",2013,"Combined taurine, epigallocatechin gallate and genistein therapy reduces HSC-T6 cell proliferation and modulates the expression of fibrogenic factors.","24129183","Genistein","Transforming Growth Factor beta1"]
["Genistein","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","21827449",2012,"Genistein aglycone, a soy-derived isoflavone, improves skin changes induced by ovariectomy in rats.","21827449","Genistein","Transforming Growth Factor beta1"]
["Genistein","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","20590611",2010,"Genistein aglycone improves skin repair in an incisional model of wound healing: a comparison with raloxifene and oestradiol in ovariectomized rats.","20590611","Genistein","Transforming Growth Factor beta1"]
["Genistein","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","14605006",2004,"The phytoestrogen genistein enhances osteogenesis and represses adipogenic differentiation of human primary bone marrow stromal cells.","14605006","Genistein","Transforming Growth Factor beta1"]
["Genistein","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","12580099",2001,"[Antifibrotic effects of genistein and quercetin in vitro].","12580099","Genistein","Transforming Growth Factor beta1"]
["Genistein","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","22884073",2012,"The effects of genistein on transforming growth factor-?1-induced invasion and metastasis in human pancreatic cancer cell line Panc-1 in vitro.","22884073","Genistein","Transforming Growth Factor beta1"]
["Genistein","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","21704028",2011,"Genistein modulates NF-?B-associated renal inflammation, fibrosis and podocyte abnormalities in fructose-fed rats.","21704028","Genistein","Transforming Growth Factor beta1"]
["Genistein","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","20661826",2010,"Enhanced mammary progesterone receptor-A isoform activity in the promotion of mammary tumor progression by dietary soy in rats.","20661826","Genistein","Transforming Growth Factor beta1"]
["Genistein","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","19119629",2008,"[Effects of genistein on expression of TGF-beta1 and intracellular free Ca2+ concentration in fibroblasts derived from human hypertrophic scar].","19119629","Genistein","Transforming Growth Factor beta1"]
["Genistein","Tissue Inhibitor of Metalloproteinase-1",0,0,1,0,"TIMP1","22884883",2012,"Inhibitory effect of genistein on the invasive potential of human cervical cancer cells via modulation of matrix metalloproteinase-9 and tissue inhibitors of matrix metalloproteinase-1 expression.","22884883","Genistein","Tissue Inhibitor of Metalloproteinase-1"]
["Genistein","Tissue Inhibitor of Metalloproteinase-1",0,0,1,0,"TIMP1","24129183",2013,"Combined taurine, epigallocatechin gallate and genistein therapy reduces HSC-T6 cell proliferation and modulates the expression of fibrogenic factors.","24129183","Genistein","Tissue Inhibitor of Metalloproteinase-1"]
["Genistein","Tissue Inhibitor of Metalloproteinase-1",0,0,1,0,"TIMP1","11778268",2000,"[Genistein exerts multiple suppressive effects on human breast carcinoma cells].","11778268","Genistein","Tissue Inhibitor of Metalloproteinase-1"]
["Genistein","Tissue Inhibitor of Metalloproteinase-1",0,0,1,0,"TIMP1","21827449",2012,"Genistein aglycone, a soy-derived isoflavone, improves skin changes induced by ovariectomy in rats.","21827449","Genistein","Tissue Inhibitor of Metalloproteinase-1"]
["Genistein","Tissue Inhibitor of Metalloproteinase-1",0,0,1,0,"TIMP1","12903810",1999,"Effects of genistein on invasion and matrix metalloproteinase activities of HT1080 human fibrosarcoma cells.","12903810","Genistein","Tissue Inhibitor of Metalloproteinase-1"]
["Genistein","Tissue Inhibitor of Metalloproteinase-1",0,0,1,0,"TIMP1","11776827",1999,"[Protein tyrosine kinase inhibitor genistein suppresses in vitro invasion of HT1080 human fibrosarcoma cells].","11776827","Genistein","Tissue Inhibitor of Metalloproteinase-1"]
["Genistein","Tissue Inhibitor of Metalloproteinase-1",0,0,1,0,"TIMP1","9673352",1998,"Genistein inhibits both constitutive and EGF-stimulated invasion in ER-negative human breast carcinoma cell lines.","9673352","Genistein","Tissue Inhibitor of Metalloproteinase-1"]
["Genistein","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","19011673",2008,"Genistein inhibits the development of atherosclerosis via inhibiting NF-kappaB and VCAM-1 expression in LDLR knockout mice.","19011673","Genistein","Vascular Cell Adhesion Molecule-1"]
["Genistein","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","22901685",2013,"Positive and negative regulation of insulin action by genistein in the endothelium.","22901685","Genistein","Vascular Cell Adhesion Molecule-1"]
["Genistein","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","15879919",2005,"Effects of soy isoflavones on endothelial function in healthy postmenopausal women.","15879919","Genistein","Vascular Cell Adhesion Molecule-1"]
["Genistein","Vascular Cell Adhesion Molecule-1",0,0,1,1,"VCAM1","17682090",2007,"Effects of the phytoestrogen genistein on some predictors of cardiovascular risk in osteopenic, postmenopausal women: a two-year randomized, double-blind, placebo-controlled study.","17682090","Genistein","Vascular Cell Adhesion Molecule-1"]
["Genistein","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","23291378",2013,"Genistein inhibits ox-LDL-induced VCAM-1, ICAM-1 and MCP-1 expression of HUVECs through heme oxygenase-1.","23291378","Genistein","Vascular Cell Adhesion Molecule-1"]
["Genistein","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","16735947",2006,"The selective estrogen receptor-beta agonist biochanin A shows vasculoprotective effects without uterotrophic activity.","16735947","Genistein","Vascular Cell Adhesion Molecule-1"]
["Genistein","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","7541425",1995,"Inhibitors of protein tyrosine kinase suppress TNF-stimulated induction of endothelial cell adhesion molecules.","7541425","Genistein","Vascular Cell Adhesion Molecule-1"]
["Gentian Violet","Collagen Type III",0,0,1,1,"COL3A1","21335346",2011,"Reduced chondrocyte viability is associated with the use of surgical marker pen ink.","21335346","Gentian Violet","Collagen Type III"]
["Glutaral","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","19024098",2008,"Mitigated calcification of glutaraldehyde-fixed bovine pericardium by tannic acid in rats.","19024098","Glutaral","Matrix Metalloproteinase 9"]
["Glycerol","Chemokine CCL2",0,0,1,1,"CCL2","17940345",2007,"Attenuation of glycerol-induced acute kidney injury by previous partial hepatectomy: role of hepatocyte growth factor/c-met axis in tubular protection.","17940345","Glycerol","Chemokine CCL2"]
["Glycerol","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","17283047",2007,"Mitogenic activity and signaling mechanism of 2-(14,15- epoxyeicosatrienoyl)glycerol, a novel cytochrome p450 arachidonate metabolite.","17283047","Glycerol","Receptor, Epidermal Growth Factor"]
["Glycerol","Receptors, LDL",0,0,1,0,"LDLR","12078992",2002,"Use of a cholesterol-rich emulsion that binds to low-density lipoprotein receptors as a vehicle for paclitaxel.","12078992","Glycerol","Receptors, LDL"]
["Glycerol","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","20353584",2010,"Adjuvant glycerol is not beneficial in experimental pneumococcal meningitis.","20353584","Glycerol","Matrix Metalloproteinase 9"]
["Glycerol","E-Selectin",0,0,1,0,"SELE","19009103",2008,"Modular synthesis of multivalent glycoarchitectures and their unique selectin binding behavior.","19009103","Glycerol","E-Selectin"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L1092,L1092)","v":"glyphosate"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M1092,M1092)","v":"Collagen Type III"},1,0,0,1,"COL3A1",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K1092,K1092)","v":"15451553"},2004,"The effects of sub-chronic exposure of Wistar rats to the herbicide Glyphosate-Biocarb.","15451553","glyphosate","Collagen Type III"]
["Hydrochlorothiazide","Chemokine CCL2",0,0,1,0,"CCL2","11897210",2002,"Effects of eprosartan versus hydrochlorothiazide on markers of vascular oxidation and inflammation and blood pressure (renin-angiotensin system antagonists, oxidation, and inflammation).","11897210","Hydrochlorothiazide","Chemokine CCL2"]
["Hydrochlorothiazide","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","10821336",2000,"Fibrinolytic function in diuretic-induced volume depletion.","10821336","Hydrochlorothiazide","Plasminogen Activator Inhibitor 1"]
["Hydrochlorothiazide","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","21107432",2011,"Olmesartan/amlodipine vs olmesartan/hydrochlorothiazide in hypertensive patients with metabolic syndrome: the OLAS study.","21107432","Hydrochlorothiazide","Vascular Cell Adhesion Molecule-1"]
["Hydrochlorothiazide","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","11897210",2002,"Effects of eprosartan versus hydrochlorothiazide on markers of vascular oxidation and inflammation and blood pressure (renin-angiotensin system antagonists, oxidation, and inflammation).","11897210","Hydrochlorothiazide","Vascular Cell Adhesion Molecule-1"]
["Hydrochlorothiazide","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","17923463",2008,"Effect of valsartan compared with valsartan/hydrochlorothiazide on plasma levels of cellular adhesion molecules: the Val-MARC trial.","17923463","Hydrochlorothiazide","Vascular Cell Adhesion Molecule-1"]
["hydroquinone","Chemokine CCL2",0,0,1,1,"CCL2","21386905",2011,"Cigarette smoke-related hydroquinone dysregulates MCP-1, VEGF and PEDF expression in retinal pigment epithelium in vitro and in vivo.","21386905","hydroquinone","Chemokine CCL2"]
["hydroquinone","Chemokine CCL2",0,0,1,1,"CCL2","20946948",2011,"The pro-apoptotic effect of hydroquinone in human neutrophils and eosinophils.","20946948","hydroquinone","Chemokine CCL2"]
["hydroquinone","Chemokine CCL2",0,0,1,1,"CCL2","22465845",2012,"In vivo hydroquinone exposure impairs MCP-1 secretion and monocyte recruitment into the inflamed lung.","22465845","hydroquinone","Chemokine CCL2"]
["hydroquinone","NF-E2-Related Factor 2",0,0,1,0,"NFE2L2","23290930",2013,"Hydroquinone regulates hemeoxygenase-1 expression via modulation of Src kinase activity through thiolation of cysteine residues.","23290930","hydroquinone","NF-E2-Related Factor 2"]
["hydroquinone","NF-E2-Related Factor 2",0,0,1,0,"NFE2L2","24096646",2013,"Diterpene para-hydroquinone compounds derived from cryptoquinone inhibit adipocyte differentiation of mouse 3T3-L1 cells and activate the Nrf2/ARE pathway.","24096646","hydroquinone","NF-E2-Related Factor 2"]
["hydroquinone","NF-E2-Related Factor 2",0,0,1,1,"NFE2L2","21059386",2011,"Essential role of Nrf2 in protection against hydroquinone- and benzoquinone-induced cytotoxicity.","21059386","hydroquinone","NF-E2-Related Factor 2"]
["hydroquinone","NF-E2-Related Factor 2",0,0,1,0,"NFE2L2","20142043",2010,"Activation of the NRF2 signaling pathway by copper-mediated redox cycling of para- and ortho-hydroquinones.","20142043","hydroquinone","NF-E2-Related Factor 2"]
["hydroquinone","Vascular Cell Adhesion Molecule-1",0,0,1,1,"VCAM1","21645265",2011,"Hydroquinone stimulates inflammatory functions in microvascular endothelial cells via NF-?B nuclear activation.","21645265","hydroquinone","Vascular Cell Adhesion Molecule-1"]
["Iodine","Receptor, Epidermal Growth Factor",0,0,0,0,"EGFR","6323589",1984,"Surface iodination of epidermal growth factor receptors in intact cells.","6323589","Iodine","Receptor, Epidermal Growth Factor"]
["Iodine","Receptors, LDL",0,0,0,0,"LDLR","22222482",2012,"Excess iodine and high-fat diet combination modulates lipid profile, thyroid hormone, and hepatic LDLr expression values in mice.","22222482","Iodine","Receptors, LDL"]
["Iodine","Receptors, LDL",0,0,0,0,"LDLR","19916081",2010,"Dose and time-dependent hypercholesterolemic effects of iodine excess via TRbeta1-mediated down regulation of hepatic LDLr gene expression.","19916081","Iodine","Receptors, LDL"]
["Iodine","Receptors, Thromboxane A2, Prostaglandin H2",0,0,0,0,"TBXA2R","8809159",1996,"Iodinated analogs of trimetoquinol as highly potent and selective beta 2-adrenoceptor ligands.","8809159","Iodine","Receptors, Thromboxane A2, Prostaglandin H2"]
["Iodine","Transforming Growth Factor beta1",0,0,0,0,"TGFB1","16232359",2005,"[The level of IGF-1 and TGF-beta-1 in the blood serum and the thyroid size in children with normal ioduria].","16232359","Iodine","Transforming Growth Factor beta1"]
["Iodine","Transforming Growth Factor beta1",0,0,0,0,"TGFB1","19737467",2009,"[Expression of AP-1 and TGF-beta1 in kidney of iodine deficient rats and its significance].","19737467","Iodine","Transforming Growth Factor beta1"]
["Iodine","Transforming Growth Factor beta1",0,0,0,0,"TGFB1","21993965",2012,"Changes of sodium iodide symporter regulated by IGF-I and TGF-?1 in mammary gland cells from lactating mice at different iodine levels.","21993965","Iodine","Transforming Growth Factor beta1"]
["Iodine","Vascular Cell Adhesion Molecule-1",0,0,0,1,"VCAM1","16832784",2006,"[Markers of endothelial dysfunction in patients with iodine induced hyperthyroidism].","16832784","Iodine","Vascular Cell Adhesion Molecule-1"]
["Isoproterenol","Chemokine CCL2",0,0,1,0,"CCL2","16644035",2006,"Isoproterenol stimulates monocyte chemoattractant protein-1 expression and secretion in 3T3-L1 adipocytes.","16644035","Isoproterenol","Chemokine CCL2"]
["Isoproterenol","Collagen Type III",0,0,1,1,"COL3A1","18783386",2008,"Mesenchymal stem cell transplantation attenuates cardiac fibrosis associated with isoproterenol-induced global heart failure.","18783386","Isoproterenol","Collagen Type III"]
["Isoproterenol","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","16227322",2006,"The beta-agonist isoproterenol attenuates EGF-stimulated wound closure in human airway epithelial cells.","16227322","Isoproterenol","Receptor, Epidermal Growth Factor"]
["Isoproterenol","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","1784831",1991,"Modulation of epidermal growth factor binding to receptor by isoproterenol and cholera toxin in primary cultured hepatocytes.","1784831","Isoproterenol","Receptor, Epidermal Growth Factor"]
["Isoproterenol","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","12704019",2003,"Beta-adrenergic agonists regulate Na-K-ATPase via p70S6k.","12704019","Isoproterenol","Receptor, Epidermal Growth Factor"]
["Isoproterenol","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","15689414",2005,"beta-Adrenergic-responsive activation of extracellular signal-regulated protein kinases in salivary cells: role of epidermal growth factor receptor and cAMP.","15689414","Isoproterenol","Receptor, Epidermal Growth Factor"]
["Isoproterenol","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","1622394",1992,"A novel mechanism for isoprenaline-stimulated proliferation of rat parotid acinar cells involving the epidermal growth factor receptor and cell surface galactosyltransferase.","1622394","Isoproterenol","Receptor, Epidermal Growth Factor"]
["Isoproterenol","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","20207737",2010,"Isoproterenol and cAMP block ERK phosphorylation and enhance [Ca2+]i increases and oxygen consumption by muscarinic receptor stimulation in rat parotid and submandibular acinar cells.","20207737","Isoproterenol","Receptor, Epidermal Growth Factor"]
["Isoproterenol","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","3009438",1986,"The involvement of cellular ATP in receptor-mediated internalization of epidermal growth factor and hormone-induced internalization of beta-adrenergic receptors.","3009438","Isoproterenol","Receptor, Epidermal Growth Factor"]
["Isoproterenol","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","21554097",2011,"Chronic ?-adrenergic stimulation increases ErbB receptors and cell proliferation in mouse kidney.","21554097","Isoproterenol","Receptor, Epidermal Growth Factor"]
["Isoproterenol","Receptors, LDL",0,0,1,0,"LDLR","1674703",1991,"Beta-adrenergic effects on cellular cholesterologenesis and low density lipoprotein metabolism.","1674703","Isoproterenol","Receptors, LDL"]
["Isoproterenol","Receptors, LDL",0,0,1,0,"LDLR","9026523",1996,"Isoproterenol decreases LDL receptor expression in rat adipose cells: activation of cyclic AMP-dependent proteolysis.","9026523","Isoproterenol","Receptors, LDL"]
["Isoproterenol","Matrix Metalloproteinase 9",0,0,1,1,"MMP9","19909738",2010,"The study of ISO induced heart failure rat model.","19909738","Isoproterenol","Matrix Metalloproteinase 9"]
["Isoproterenol","Matrix Metalloproteinase 9",0,0,1,1,"MMP9","18594475",2008,"The endothelin receptor antagonist CPU0213 is more effective than aminoguanidine to attenuate isoproterenol-induced vascular abnormality by suppressing overexpression of NADPH oxidase [correction of oxidas], ETA, ETB, and MMP9 in the vasculature.","18594475","Isoproterenol","Matrix Metalloproteinase 9"]
["Isoproterenol","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","19597524",2009,"Isoproterenol disperses distribution of NADPH oxidase, MMP-9, and pPKCepsilon in the heart, which are mitigated by endothelin receptor antagonist CPU0213.","19597524","Isoproterenol","Matrix Metalloproteinase 9"]
["Isoproterenol","Matrix Metalloproteinase 9",0,0,1,1,"MMP9","20823567",2010,"Effects of captopril and telmisartan on matrix metalloproteinase-2 and -9 expressions and development of left ventricular fibrosis induced by isoprenaline in rats.","20823567","Isoproterenol","Matrix Metalloproteinase 9"]
["Isoproterenol","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","17283249",2007,"Beta1 integrins modulate beta-adrenergic receptor-stimulated cardiac myocyte apoptosis and myocardial remodeling.","17283249","Isoproterenol","Matrix Metalloproteinase 9"]
["Isoproterenol","NF-E2-Related Factor 2",0,0,1,0,"NFE2L2","21763292",2011,"??-adrenergic receptor-mediated HO-1 induction, via PI3K and p38 MAPK, by isoproterenol in RAW 264.7 cells leads to inhibition of HMGB1 release in LPS-activated RAW 264.7 cells and increases in survival rate of CLP-induced septic mice.","21763292","Isoproterenol","NF-E2-Related Factor 2"]
["Isoproterenol","Serum Amyloid A Protein",0,0,1,1,"SAA1","23473367",2013,"Serum biomarkers reveal long-term cardiac injury in isoproterenol-treated African green monkeys.","23473367","Isoproterenol","Serum Amyloid A Protein"]
["Isoproterenol","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","7586269",1995,"The circulatory regulation of TPA and UPA secretion, clearance, and inhibition during exercise and during the infusion of isoproterenol and phenylephrine.","7586269","Isoproterenol","Plasminogen Activator Inhibitor 1"]
["Isoproterenol","Transforming Growth Factor beta1",0,0,1,1,"TGFB1","22732653",2012,"Rosuvastatin promotes angiogenesis and reverses isoproterenol-induced acute myocardial infarction in rats: role of iNOS and VEGF.","22732653","Isoproterenol","Transforming Growth Factor beta1"]
["Isoproterenol","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","21854795",2011,"Reduction of isoprenaline-induced myocardial TGF-?1 expression and fibrosis in osthole-treated mice.","21854795","Isoproterenol","Transforming Growth Factor beta1"]
["Isoproterenol","Tissue Inhibitor of Metalloproteinase-1",0,0,1,0,"TIMP1","16731796",2006,"Tissue inhibitor of metalloproteinase 1 expression and secretion are induced by beta-adrenergic stimulation in 3T3-L1 adipocytes.","16731796","Isoproterenol","Tissue Inhibitor of Metalloproteinase-1"]
["Isoproterenol","Tissue Inhibitor of Metalloproteinase-1",0,0,1,0,"TIMP1","24286936",2014,"Isoproterenol effects evaluated in heart slices of human and rat in comparison to rat heart in vivo.","24286936","Isoproterenol","Tissue Inhibitor of Metalloproteinase-1"]
["limonene","Chemokine CCL2",0,0,1,0,"CCL2","20492298",2010,"Anti-inflammatory effects of limonene from yuzu (Citrus junos Tanaka) essential oil on eosinophils.","20492298","limonene","Chemokine CCL2"]
["limonene","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","23554130",2013,"Human breast tissue disposition and bioactivity of limonene in women with early-stage breast cancer.","23554130","limonene","Transforming Growth Factor beta1"]
["Lindane","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","15749814",2005,"Lindane, a gap junction blocker, suppresses FSH and transforming growth factor beta1-induced connexin43 gap junction formation and steroidogenesis in rat granulosa cells.","15749814","Lindane","Transforming Growth Factor beta1"]
["Lovastatin","Chemokine CCL2",0,0,1,0,"CCL2","10908155",2000,"Inhibition of monocyte chemotactic protein-1 synthesis by statins.","10908155","Lovastatin","Chemokine CCL2"]
["Lovastatin","Chemokine CCL2",0,0,1,0,"CCL2","18672387",2009,"Mevastatin reduces cartilage degradation in rabbit experimental osteoarthritis through inhibition of synovial inflammation.","18672387","Lovastatin","Chemokine CCL2"]
["Lovastatin","Chemokine CCL2",0,0,1,0,"CCL2","21815729",2011,"Lysophosphatidic acid and lovastatin might protect kidney in renal I/R injury by downregulating MCP-1 in rat.","21815729","Lovastatin","Chemokine CCL2"]
["Lovastatin","Chemokine CCL2",0,0,1,0,"CCL2","14527367",2003,"Inhibition of lovastatin on proliferation and expression of proinflammatory cytokines in cultured human glomerular mesangial cells.","14527367","Lovastatin","Chemokine CCL2"]
["Lovastatin","Chemokine CCL2",0,0,1,0,"CCL2","9428473",1998,"Lovastatin reduces glomerular macrophage influx and expression of monocyte chemoattractant protein-1 mRNA in nephrotic rats.","9428473","Lovastatin","Chemokine CCL2"]
["Lovastatin","Chemokine CCL2",0,0,1,0,"CCL2","7564103",1995,"Human mesangial cell production of monocyte chemoattractant protein-1: modulation by lovastatin.","7564103","Lovastatin","Chemokine CCL2"]
["Lovastatin","Antigens, CD40",0,0,1,0,"CD40","15378516",2004,"Lovastatin modulation of microglial activation via suppression of functional CD40 expression.","15378516","Lovastatin","Antigens, CD40"]
["Lovastatin","Antigens, CD40",0,0,1,0,"CD40","16141529",2005,"Lovastatin reduces nuclear factor kappaB activation induced by C-reactive protein in human vascular endothelial cells.","16141529","Lovastatin","Antigens, CD40"]
["Lovastatin","Antigens, CD40",0,0,1,0,"CD40","16472124",2006,"Lovastatin reduces apoptosis and downregulates the CD40 expression induced by TNF-alpha in cerebral vascular endothelial cells.","16472124","Lovastatin","Antigens, CD40"]
["Lovastatin","Antigens, CD40",0,0,1,0,"CD40","15467191",2004,"C-reactive protein-induced expression of CD40-CD40L and the effect of lovastatin and fenofibrate on it in human vascular endothelial cells.","15467191","Lovastatin","Antigens, CD40"]
["Lovastatin","Collagen Type III",0,0,1,0,"COL3A1","12713866",2003,"Effect of HMG-CoA reductase inhibitors on proliferation and protein synthesis by rat hepatic stellate cells.","12713866","Lovastatin","Collagen Type III"]
["Lovastatin","Macrophage Colony-Stimulating Factor",0,0,1,0,"CSF1","15520325",2004,"Statins enhance migratory capacity by upregulation of the telomere repeat-binding factor TRF2 in endothelial progenitor cells.","15520325","Lovastatin","Macrophage Colony-Stimulating Factor"]
["Lovastatin","Macrophage Colony-Stimulating Factor",0,0,1,0,"CSF1","14644448",2003,"Statins induce suppressor of cytokine signaling-3 in macrophages.","14644448","Lovastatin","Macrophage Colony-Stimulating Factor"]
["Lovastatin","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","12942316",2003,"Epidermal growth factor receptor-targeted therapy potentiates lovastatin-induced apoptosis in head and neck squamous cell carcinoma cells.","12942316","Lovastatin","Receptor, Epidermal Growth Factor"]
["Lovastatin","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","19224573",2009,"Mevastatin-induced neurite outgrowth of neuroblastoma cells via activation of EGFR.","19224573","Lovastatin","Receptor, Epidermal Growth Factor"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L1156,L1156)","v":"Lovastatin"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M1156,M1156)","v":"Receptor, Epidermal Growth Factor"},0,0,1,0,"EGFR",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K1156,K1156)","v":"21245384"},2011,"Therapeutic levels of the hydroxmethylglutaryl-coenzyme A reductase inhibitor lovastatin activate ras signaling via phospholipase D2.","21245384","Lovastatin","Receptor, Epidermal Growth Factor"]
["Lovastatin","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","20562912",2010,"Lovastatin inhibits EGFR dimerization and AKT activation in squamous cell carcinoma cells: potential regulation by targeting rho proteins.","20562912","Lovastatin","Receptor, Epidermal Growth Factor"]
["Lovastatin","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","19760159",2010,"Lovastatin overcomes gefitinib resistance in human non-small cell lung cancer cells with K-Ras mutations.","19760159","Lovastatin","Receptor, Epidermal Growth Factor"]
["Lovastatin","Receptor, Epidermal Growth Factor",0,0,1,1,"EGFR","16857822",2006,"Strategies to enhance epidermal growth factor inhibition: targeting the mevalonate pathway.","16857822","Lovastatin","Receptor, Epidermal Growth Factor"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","22788770",2012,"The association of statins plus LDL receptor-targeted liposome-encapsulated doxorubicin increases in vitro drug delivery across blood-brain barrier cells.","22788770","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","15161671",2004,"Cholesterol synthesis and import contribute to protective cholesterol increments in acute myeloid leukemia cells.","15161671","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","2317163",1990,"Unexpected failure of bile acid malabsorption to stimulate cholesterol synthesis in sitosterolemia with xanthomatosis. Comparison with lovastatin.","2317163","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","2062789",1991,"Reduction of LDL production rate in ileal bypassed rabbits treated with lovastatin.","2062789","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","2044637",1991,"Lowering of plasma cholesterol levels in animals by lovastatin and simvastatin.","2044637","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","10781690",2000,"Partial restoration of all trans retinoic acid (ATRA) sensitivity by compactin in ATRA-resistant leukemic cells (ATRA-R HL-60).","10781690","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","21118482",2010,"Synergic effect of eicosapentaenoic acid and lovastatin on gene expression of HMGCoA reductase and LDL receptor in cultured HepG2 cells.","21118482","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","1671145",1991,"Poor response to simvastatin in familial defective apo-B-100.","1671145","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","1431581",1992,"Cholesteryl ester storage disease: complex molecular effects of chronic lovastatin therapy.","1431581","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","2167097",1990,"Effect of simvastatin (MK-733) on the regulation of cholesterol synthesis in Hep G2 cells.","2167097","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","11480454",2000,"Relative induction of mRNA for HMG CoA reductase and LDL receptor by five different HMG-CoA reductase inhibitors in cultured human cells.","11480454","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","12952856",2003,"Proximal tubular cholesterol loading after mitochondrial, but not glycolytic, blockade.","12952856","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","2418882",1986,"Calmodulin antagonists stimulate LDL receptor synthesis in human skin fibroblasts.","2418882","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","2360916",1990,"Effects of lovastatin therapy on LDL receptor activity in circulating monocytes and on structure and composition of plasma lipoproteins.","2360916","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","1764540",1991,"Dual effect of lovastatin and simvastatin on LDL-macrophage interaction.","1764540","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","21903868",2011,"A novel bisphosphonate inhibitor of squalene synthase combined with a statin or a nitrogenous bisphosphonate in vitro.","21903868","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","1785747",1991,"[Study of LDL receptors and response to lovastatin therapy in familial homozygotic hypercholesterolemia].","1785747","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","2159099",1990,"Inhibition of cholesterol synthesis by lovastatin tested on six human cell types in vitro.","2159099","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","23559630",2013,"Transintestinal cholesterol excretion is an active metabolic process modulated by PCSK9 and statin involving ABCB1.","23559630","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","2106347",1990,"Comparative effects of simvastatin (MK-733) and pravastatin (CS-514) on hypercholesterolemia induced by cholesterol feeding in rabbits.","2106347","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","1627634",1992,"Regulation of HMG-CoA reductase, apoprotein-B and LDL receptor gene expression by the hypocholesterolemic drugs simvastatin and ciprofibrate in Hep G2, human and rat hepatocytes.","1627634","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","1816322",1991,"Regulation of cholesterol biosynthesis in sitosterolemia: effects of lovastatin, cholestyramine, and dietary sterol restriction.","1816322","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","2610723",1989,"Effect of simvastatin on receptor-dependent low density lipoprotein catabolism in normocholesterolemic human volunteers.","2610723","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","2614261",1989,"Effects of lovastatin therapy on guinea pig low density lipoprotein composition and metabolism.","2614261","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","2112479",1990,"The effects of simvastatin on plasma lipoproteins and cholesterol homeostasis in patients with heterozygous familial hypercholesterolaemia.","2112479","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","6089762",1984,"Effects of compactin, mevalonate and low-density lipoprotein on 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity and low-density-lipoprotein-receptor activity in the human hepatoma cell line Hep G2.","6089762","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","3903562",1985,"Regulation of plasma cholesterol by compactin and mevinolin.","3903562","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","17058264",2006,"Plasma cholesterol is hyperresponsive to statin in ABCG5/ABCG8 transgenic mice.","17058264","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","2010669",1991,"Effect of probucol on blood cholesterol and basal and lovastatin-induced 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in mice.","2010669","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","15485695",2004,"Synergistic upregulation of low-density lipoprotein receptor activity by tamoxifen and lovastatin.","15485695","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","3663697",1987,"Altered function and structure of low-density lipoprotein receptor in compactin (ML236B)-resistant mutants of Chinese hamster cells.","3663697","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","15531276",2004,"Lowering plasma cholesterol by raising ldl receptors. 1981.","15531276","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","6087838",1984,"Inhibition of cholesterol synthesis by mevinolin stimulates low density lipoprotein receptor activity in human monocyte-derived macrophages.","6087838","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","3055919",1988,"Discovery, biochemistry and biology of lovastatin.","3055919","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","3988813",1985,"Defective endocytosis of low-density lipoprotein in monensin-resistant mutants of the mouse Balb/3T3 cell line.","3988813","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","3029155",1987,"The effect of mevinolin on steroidogenesis in patients with defects in the low density lipoprotein receptor pathway.","3029155","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","3569277",1987,"Overaccumulation of 3-hydroxy-3-methylglutaryl-coenzyme-A reductase in a compactin(ML-236B)-resistant mouse cell line with defects in the regulation of its activity.","3569277","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","17184503",2006,"Regulation of hepatic cholesterol metabolism in CETP/LDLr mice by cholesterol feeding and by drugs (cholestyramine and lovastatin) that lower plasma cholesterol.","17184503","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","3534334",1986,"Normal cholesterol levels with lovastatin (mevinolin) therapy in a child with homozygous familial hypercholesterolemia following liver transplantation.","3534334","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","3464957",1986,"Mevinolin, an inhibitor of cholesterol synthesis, induces mRNA for low density lipoprotein receptor in livers of hamsters and rabbits.","3464957","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","3397806",1988,"Lovastatin therapy in receptor-negative homozygous familial hypercholesterolemia: lack of effect on low-density lipoprotein concentrations or turnover.","3397806","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","6090292",1984,"Regulation of low density lipoprotein receptor function in a human hepatoma cell line.","6090292","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","10323779",1999,"Lovastatin decreases the receptor-mediated degradation of acetylated and oxidized LDLs in human blood monocytes during the early stage of differentiation into macrophages.","10323779","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","3816797",1987,"Regulation of synthesis and cell content of the low-density-lipoprotein receptor protein in cultured fibroblasts from normal and familial hypercholesterolaemic subjects.","3816797","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","9933026",1999,"The expression of the lectin-like oxidized low-density lipoprotein receptor (LOX-1) on human vascular smooth muscle cells and monocytes and its down-regulation by lovastatin.","9933026","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","8292099",1993,"The effects of hypercholesterolaemia, simvastatin and dietary fat on the low density lipoprotein receptor of unstimulated mononuclear cells.","8292099","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","6265781",1981,"Lowering plasma cholesterol by raising LDL receptors.","6265781","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","9196047",1997,"Lovastatin increases surface low density lipoprotein receptor expression by retarding the receptor internalization rate in proliferating lymphocytes.","9196047","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","9244400",1997,"Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase unmask transcriptional regulation of hepatic low-density lipoprotein receptor gene expression by dietary cholesterol.","9244400","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","8451300",1993,"Lovastatin potentiates the photocytotoxic effect of photofrin II delivered to HT29 human colonic adenocarcinoma cells by low density lipoprotein.","8451300","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","6388097",1983,"Mevinolin stimulates receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholesterolemia heterozygotes.","6388097","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","9555954",1998,"Three-fold effect of lovastatin treatment on low density lipoprotein metabolism in subjects with hyperlipidemia: increase in receptor activity, decrease in apoB production, and decrease in particle affinity for the receptor. Results from a novel triple-tracer approach.","9555954","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","9678770",1998,"The effects of diet and lovastatin on regression of fatty streak lesions and on hepatic and intestinal mRNA levels for the LDL receptor and HMG CoA reductase in F1B hamsters.","9678770","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","6267041",1981,"The effects of subfractions of high density lipoprotein on cholesterol efflux from cultured fibroblasts. Regulation of low density lipoprotein receptor activity.","6267041","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","6317039",1983,"Regulation of hepatic receptor-dependent degradation of LDL by mevinolin in rabbits with hypercholesterolemia induced by a wheat starch-casein diet.","6317039","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","6494735",1984,"Acinar cell carcinoma of rat pancreas: mechanism of deregulation of cholesterol metabolism.","6494735","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","8457250",1993,"Influence of specific mutations at the LDL-receptor gene locus on the response to simvastatin therapy in Afrikaner patients with heterozygous familial hypercholesterolaemia.","8457250","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","7853722",1994,"[HMG-CoA reductase inhibitor for therapy of patients with hyperlipoproteinemia ].","7853722","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","7595080",1995,"Effects of stigmastanyl-phosphocholine (Ro 16-6532) and lovastatin on lipid and lipoprotein levels and lipoprotein metabolism in the hamster on different diets.","7595080","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","8719939",1995,"Is responsiveness to lovastatin in familial hypercholesterolaemia heterozygotes influenced by the specific mutation in the low-density lipoprotein receptor gene?","8719939","Lovastatin","Receptors, LDL"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L1220,L1220)","v":"Lovastatin"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M1220,M1220)","v":"Receptors, LDL"},0,0,1,0,"LDLR",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K1220,K1220)","v":"7708017"},1995,"An in vitro study of the effects of lovastatin on human fetal brain cells.","7708017","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","8345800",1993,"The response to lovastatin treatment in patients with heterozygous familial hypercholesterolemia is modulated by apolipoprotein E polymorphism.","8345800","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","7830029",1995,"Heterozygous familial hypercholesterolaemia: the influence of the mutation type of the low-density-lipoprotein receptor gene and PvuII polymorphism of the normal allele on serum lipid levels and response to lovastatin treatment.","7830029","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","8831932",1996,"Familial defective apolipoprotein B-100 (FDB): effect of simvastatin therapy on LDL-receptor binding.","8831932","Lovastatin","Receptors, LDL"]
["Lovastatin","Receptors, LDL",0,0,1,0,"LDLR","9069523",1997,"Statin therapy in a kindred with both apolipoprotein B and low density lipoprotein receptor gene defects.","9069523","Lovastatin","Receptors, LDL"]
["Lovastatin","Matrix Metalloproteinase 1",0,0,1,0,"MMP1","12663370",2003,"Statins inhibit secretion of metalloproteinases-1, -2, -3, and -9 from vascular smooth muscle cells and macrophages.","12663370","Lovastatin","Matrix Metalloproteinase 1"]
["Lovastatin","Matrix Metalloproteinase 1",0,0,1,0,"MMP1","23705487",2013,"[Inhibition of the stellate cells using lisinopril and lovastatin for prophylaxis of pancreatic stump fibrosis after performance of distal resection in a model of chronic alcoholic pancreatitis].","23705487","Lovastatin","Matrix Metalloproteinase 1"]
["Lovastatin","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","19360310",2009,"Simvastatin and lovastatin inhibit breast cell invasion induced by H-Ras.","19360310","Lovastatin","Matrix Metalloproteinase 9"]
["Lovastatin","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","15467191",2004,"C-reactive protein-induced expression of CD40-CD40L and the effect of lovastatin and fenofibrate on it in human vascular endothelial cells.","15467191","Lovastatin","Matrix Metalloproteinase 9"]
["Lovastatin","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","11053993",2000,"Suppression of invasion and MMP-9 expression in NIH 3T3 and v-H-Ras 3T3 fibroblasts by lovastatin through inhibition of ras isoprenylation.","11053993","Lovastatin","Matrix Metalloproteinase 9"]
["Lovastatin","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","12663370",2003,"Statins inhibit secretion of metalloproteinases-1, -2, -3, and -9 from vascular smooth muscle cells and macrophages.","12663370","Lovastatin","Matrix Metalloproteinase 9"]
["Lovastatin","Serum Amyloid A Protein",0,0,1,0,"SAA1","18285405",2008,"Lovastatin inhibits formation of AA amyloid.","18285405","Lovastatin","Serum Amyloid A Protein"]
["Lovastatin","E-Selectin",0,0,1,0,"SELE","16273297",2005,"Lovastatin stimulates p75 TNF receptor (TNFR2) expression in primary human endothelial cells.","16273297","Lovastatin","E-Selectin"]
["Lovastatin","E-Selectin",0,0,1,0,"SELE","12119193",2002,"Lovastatin-stimulated superinduction of E-selectin, ICAM-1 and VCAM-1 in TNF-alpha activated human vascular endothelial cells.","12119193","Lovastatin","E-Selectin"]
["Lovastatin","E-Selectin",0,0,1,0,"SELE","14988223",2004,"Ionizing radiation-induced E-selectin gene expression and tumor cell adhesion is inhibited by lovastatin and all-trans retinoic acid.","14988223","Lovastatin","E-Selectin"]
["Lovastatin","E-Selectin",0,0,1,0,"SELE","21445895",2011,"Inhibition of endothelial adhesion molecule expression by Monascus purpureus-fermented rice metabolites, monacolin K, ankaflavin, and monascin.","21445895","Lovastatin","E-Selectin"]
["Lovastatin","E-Selectin",0,0,1,0,"SELE","14630701",2004,"Lovastatin inhibits Rho-regulated expression of E-selectin by TNFalpha and attenuates tumor cell adhesion.","14630701","Lovastatin","E-Selectin"]
["Lovastatin","E-Selectin",0,0,1,0,"SELE","11716764",2001,"Diverse effects of inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase on the expression of VCAM-1 and E-selectin in endothelial cells.","11716764","Lovastatin","E-Selectin"]
["Lovastatin","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","15718495",2005,"Interleukin-6 and mevastatin regulate plasminogen activator inhibitor-1 through CCAAT/enhancer-binding protein-delta.","15718495","Lovastatin","Plasminogen Activator Inhibitor 1"]
["Lovastatin","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","17245169",2007,"Statins (HMG-CoA reductase inhibitors) decrease postoperative adhesions by increasing peritoneal fibrinolytic activity.","17245169","Lovastatin","Plasminogen Activator Inhibitor 1"]
["Lovastatin","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","14620928",2003,"Increased expression of plasminogen activator inhibitor-1 by mediators of the acute phase response: a potential progenitor of vasculopathy in hypertensives.","14620928","Lovastatin","Plasminogen Activator Inhibitor 1"]
["Lovastatin","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","18061125",2008,"Lovastatin inhibits oxidized low-density lipoprotein-induced plasminogen activator inhibitor and transforming growth factor-beta1 expression via a decrease in Ras/extracellular signal-regulated kinase activity in mesangial cells.","18061125","Lovastatin","Plasminogen Activator Inhibitor 1"]
["Lovastatin","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","22621227",2012,"Short-term high-dose effect of lovastatin on thrombolysis by rt-PA in a human whole-blood in vitro clot model.","22621227","Lovastatin","Plasminogen Activator Inhibitor 1"]
["Lovastatin","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","9381994",1997,"Comparison of bezafibrate versus lovastatin for lowering plasma insulin, fibrinogen, and plasminogen activator inhibitor-1 concentrations in hyperlipemic heart transplant patients.","9381994","Lovastatin","Plasminogen Activator Inhibitor 1"]
["Lovastatin","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","7942538",1994,"Effects of lovastatin therapy on plasminogen activator inhibitor-1 antigen levels.","7942538","Lovastatin","Plasminogen Activator Inhibitor 1"]
["Lovastatin","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","22129737",2011,"Inhibitory effects of clinical reagents having anti-oxidative activity on transforming growth factor-?1-induced expression of ?-smooth muscle actin in human fetal lung fibroblasts.","22129737","Lovastatin","Transforming Growth Factor beta1"]
["Lovastatin","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","23485731",2013,"Lovastatin-induced decrease of intracellular cholesterol level attenuates fibroblast-to-myofibroblast transition in bronchial fibroblasts derived from asthmatic patients.","23485731","Lovastatin","Transforming Growth Factor beta1"]
["Lovastatin","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","18061125",2008,"Lovastatin inhibits oxidized low-density lipoprotein-induced plasminogen activator inhibitor and transforming growth factor-beta1 expression via a decrease in Ras/extracellular signal-regulated kinase activity in mesangial cells.","18061125","Lovastatin","Transforming Growth Factor beta1"]
["Lovastatin","Thrombomodulin",0,0,1,0,"THBD","19419936",2009,"The influence of lovastatin on thrombomodulin gene expression in vascular endothelial cells--in vitro study.","19419936","Lovastatin","Thrombomodulin"]
["Lovastatin","Tissue Inhibitor of Metalloproteinase-1",0,0,1,0,"TIMP1","12663370",2003,"Statins inhibit secretion of metalloproteinases-1, -2, -3, and -9 from vascular smooth muscle cells and macrophages.","12663370","Lovastatin","Tissue Inhibitor of Metalloproteinase-1"]
["Lovastatin","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","19689459",2009,"Fluvastatin and lovastatin inhibit granulocyte macrophage-colony stimulating factor-stimulated human eosinophil adhesion to inter-cellular adhesion molecule-1 under flow conditions.","19689459","Lovastatin","Vascular Cell Adhesion Molecule-1"]
["Lovastatin","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","21445895",2011,"Inhibition of endothelial adhesion molecule expression by Monascus purpureus-fermented rice metabolites, monacolin K, ankaflavin, and monascin.","21445895","Lovastatin","Vascular Cell Adhesion Molecule-1"]
["Lovastatin","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","11716764",2001,"Diverse effects of inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase on the expression of VCAM-1 and E-selectin in endothelial cells.","11716764","Lovastatin","Vascular Cell Adhesion Molecule-1"]
["Lovastatin","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","12119193",2002,"Lovastatin-stimulated superinduction of E-selectin, ICAM-1 and VCAM-1 in TNF-alpha activated human vascular endothelial cells.","12119193","Lovastatin","Vascular Cell Adhesion Molecule-1"]
["Maneb","NF-E2-Related Factor 2",0,0,1,1,"NFE2L2","21402726",2011,"Maneb and paraquat-mediated neurotoxicity: involvement of peroxiredoxin/thioredoxin system.","21402726","Maneb","NF-E2-Related Factor 2"]
["Maneb","NF-E2-Related Factor 2",0,0,1,1,"NFE2L2","23764462",2013,"Maneb causes pro-oxidant effects in the hippocampus of Nrf2 knockout mice.","23764462","Maneb","NF-E2-Related Factor 2"]
["Mercuric Chloride","Tissue Inhibitor of Metalloproteinase-1",1,0,1,1,"TIMP1","11817102",2001,"Kinetics of matrix metalloproteinases and their regulatory factors in mercuric chloride-induced tubulointerstitial fibrosis in Brown Norway rats.","11817102","Mercuric Chloride","Tissue Inhibitor of Metalloproteinase-1"]
["Methotrexate","Chemokine CCL2",0,0,1,0,"CCL2","10464551",1999,"Relationship between serum RANTES levels and radiological progression in rheumatoid arthritis patients treated with methotrexate.","10464551","Methotrexate","Chemokine CCL2"]
["Methotrexate","Chemokine CCL2",0,0,1,0,"CCL2","12823287",2003,"Suppressive effect of combination treatment of leflunomide and methotrexate on chemokine expression in patients with rheumatoid arthritis.","12823287","Methotrexate","Chemokine CCL2"]
["Methotrexate","Collagen Type III",0,0,1,0,"COL3A1","16866998",2006,"Methotrexate: improving safety profile.","16866998","Methotrexate","Collagen Type III"]
["Methotrexate","Collagen Type III",0,0,1,0,"COL3A1","19884981",2009,"Effects of methotrexate on plasma cytokines and cardiac remodeling and function in postmyocarditis rats.","19884981","Methotrexate","Collagen Type III"]
["Methotrexate","Collagen Type III",0,0,1,1,"COL3A1","19903179",2010,"Daily practice assessment of liver injury in patients with psoriasis on methotrexate.","19903179","Methotrexate","Collagen Type III"]
["Methotrexate","Collagen Type III",0,0,1,0,"COL3A1","23932312",2014,"Effect of tocilizumab combined with methotrexate on circulating biomarkers of synovium, cartilage, and bone in the LITHE study.","23932312","Methotrexate","Collagen Type III"]
["Methotrexate","Macrophage Colony-Stimulating Factor",0,0,1,0,"CSF1","10219526",1999,"Improved efficacy of a microencapsulated macrophage colony stimulating factor and methotrexate in melanoma.","10219526","Methotrexate","Macrophage Colony-Stimulating Factor"]
["Methotrexate","Macrophage Colony-Stimulating Factor",0,0,1,0,"CSF1","9708448",1998,"Effects of myelotoxic agents on cytokine production in murine long-term bone marrow cultures.","9708448","Methotrexate","Macrophage Colony-Stimulating Factor"]
["Methotrexate","Chemokine CXCL10",0,0,1,1,"CXCL10","22147649",2012,"A phase II, randomized, double-blind, placebo-controlled study evaluating the efficacy and safety of MDX-1100, a fully human anti-CXCL10 monoclonal antibody, in combination with methotrexate in patients with rheumatoid arthritis.","22147649","Methotrexate","Chemokine CXCL10"]
["Methotrexate","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","24084527",2013,"Medical treatment of ectopic pregnancy: is there something new?","24084527","Methotrexate","Receptor, Epidermal Growth Factor"]
["Methotrexate","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","16432162",2006,"Targeted delivery of methotrexate to epidermal growth factor receptor-positive brain tumors by means of cetuximab (IMC-C225) dendrimer bioconjugates.","16432162","Methotrexate","Receptor, Epidermal Growth Factor"]
["Methotrexate","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","18803016",2008,"Effect of transforming growth factor-alpha on enterocyte apoptosis is correlated with EGF receptor expression along the villus-crypt axis during methotrexate-induced intestinal mucositis in a rat.","18803016","Methotrexate","Receptor, Epidermal Growth Factor"]
["Methotrexate","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","12810643",2003,"Epidermal growth factor receptor (EGFR)-targeted immunoliposomes mediate specific and efficient drug delivery to EGFR- and EGFRvIII-overexpressing tumor cells.","12810643","Methotrexate","Receptor, Epidermal Growth Factor"]
["Methotrexate","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","12234595",2002,"Comparative antiproliferative effects of (111)In-DTPA-hEGF, chemotherapeutic agents and gamma-radiation on EGFR-positive breast cancer cells.","12234595","Methotrexate","Receptor, Epidermal Growth Factor"]
["Methotrexate","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","11920686",2002,"Effects of TGF-alpha gene knockout on epithelial cell kinetics and repair of methotrexate-induced damage in mouse small intestine.","11920686","Methotrexate","Receptor, Epidermal Growth Factor"]
["Methotrexate","Receptors, LDL",0,0,1,0,"LDLR","24065615",2013,"Anti-atherogenic effects of methotrexate carried by a lipid nanoemulsion that binds to LDL receptors in cholesterol-fed rabbits.","24065615","Methotrexate","Receptors, LDL"]
["Methotrexate","Matrix Metalloproteinase 1",0,0,1,0,"MMP1","19000788",2009,"Differential influences of bucillamine and methotrexate on the generation of fibroblast-like cells from bone marrow CD34+ cells of rheumatoid arthritis patients.","19000788","Methotrexate","Matrix Metalloproteinase 1"]
["Methotrexate","Matrix Metalloproteinase 1",0,0,1,1,"MMP1","12528101",2003,"Adalimumab, a fully human anti-tumor necrosis factor alpha monoclonal antibody, for the treatment of rheumatoid arthritis in patients taking concomitant methotrexate: the ARMADA trial.","12528101","Methotrexate","Matrix Metalloproteinase 1"]
["Methotrexate","Matrix Metalloproteinase 1",0,0,1,0,"MMP1","10888709",2000,"Enhanced production of tissue inhibitor of metalloproteinases by peripheral blood mononuclear cells of rheumatoid arthritis patients responding to methotrexate treatment.","10888709","Methotrexate","Matrix Metalloproteinase 1"]
["Methotrexate","Matrix Metalloproteinase 9",0,0,1,1,"MMP9","22220905",2012,"Deregulation of the CXCL12/CXCR4 axis in methotrexate chemotherapy-induced damage and recovery of the bone marrow microenvironment.","22220905","Methotrexate","Matrix Metalloproteinase 9"]
["Methotrexate","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","24065615",2013,"Anti-atherogenic effects of methotrexate carried by a lipid nanoemulsion that binds to LDL receptors in cholesterol-fed rabbits.","24065615","Methotrexate","Matrix Metalloproteinase 9"]
["Methotrexate","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","15264885",2004,"Synthesis and characterization of dextran-peptide-methotrexate conjugates for tumor targeting via mediation by matrix metalloproteinase II and matrix metalloproteinase IX.","15264885","Methotrexate","Matrix Metalloproteinase 9"]
["Methotrexate","Matrix Metalloproteinase 9",0,0,1,1,"MMP9","16187287",2006,"Antitumor efficacy of a novel polymer-peptide-drug conjugate in human tumor xenograft models.","16187287","Methotrexate","Matrix Metalloproteinase 9"]
["Methotrexate","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","21587257",2011,"Continuous low-dose cyclophosphamide and methotrexate combined with celecoxib for patients with advanced cancer.","21587257","Methotrexate","Matrix Metalloproteinase 9"]
["Methotrexate","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","19127866",2008,"[Effects of methopterin on osteoclasts and study of its mechanism of action].","19127866","Methotrexate","Matrix Metalloproteinase 9"]
["Methotrexate","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","19487269",2009,"E-selectin, interleukin 18, serum amyloid a, and matrix metalloproteinase 9 are associated with clinical response to golimumab plus methotrexate in patients with active rheumatoid arthritis despite methotrexate therapy.","19487269","Methotrexate","Matrix Metalloproteinase 9"]
["Methotrexate","NF-E2-Related Factor 2",0,0,1,1,"NFE2L2","24231097",2013,"Pomegranate reverses methotrexate-induced oxidative stress and apoptosis in hepatocytes by modulating Nrf2-NF-?B pathways.","24231097","Methotrexate","NF-E2-Related Factor 2"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L1284,L1284)","v":"Methotrexate"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M1284,M1284)","v":"Serum Amyloid A Protein"},0,0,1,0,"SAA1",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K1284,K1284)","v":"19487269"},2009,"E-selectin, interleukin 18, serum amyloid a, and matrix metalloproteinase 9 are associated with clinical response to golimumab plus methotrexate in patients with active rheumatoid arthritis despite methotrexate therapy.","19487269","Methotrexate","Serum Amyloid A Protein"]
["Methotrexate","Serum Amyloid A Protein",0,0,1,0,"SAA1","21452922",2011,"Methotrexate chronotherapy is effective against rheumatoid arthritis.","21452922","Methotrexate","Serum Amyloid A Protein"]
["Methotrexate","Serum Amyloid A Protein",0,0,1,1,"SAA1","20536605",2010,"A case of emphysematous pyelonephritis in a patient with rheumatoid arthritis taking corticosteroid and low-dose methotrexate.","20536605","Methotrexate","Serum Amyloid A Protein"]
["Methotrexate","E-Selectin",0,0,1,0,"SELE","23465067",2013,"Serum levels of lipoprotein(a) and E-selectin are reduced in rheumatoid arthritis patients treated with methotrexate or methotrexate in combination with TNF-?-inhibitor.","23465067","Methotrexate","E-Selectin"]
["Methotrexate","E-Selectin",0,0,1,0,"SELE","19487269",2009,"E-selectin, interleukin 18, serum amyloid a, and matrix metalloproteinase 9 are associated with clinical response to golimumab plus methotrexate in patients with active rheumatoid arthritis despite methotrexate therapy.","19487269","Methotrexate","E-Selectin"]
["Methotrexate","E-Selectin",0,0,1,0,"SELE","11016854",2000,"Circulating levels of soluble E-selectin, ICAM-1 and VCAM-1 in bullous pemphigoid during low-dose methotrexate therapy. A prospective study.","11016854","Methotrexate","E-Selectin"]
["Methotrexate","E-Selectin",0,0,1,0,"SELE","15217363",2004,"Methotrexate markedly reduces the expression of vascular E-selectin, cutaneous lymphocyte-associated antigen and the numbers of mononuclear leucocytes in psoriatic skin.","15217363","Methotrexate","E-Selectin"]
["Methotrexate","E-Selectin",0,0,1,0,"SELE","15009098",2004,"Altered tissue expression pattern of cell adhesion molecules, ICAM-1, E-selectin and VCAM-1, in bullous pemphigoid during methotrexate therapy.","15009098","Methotrexate","E-Selectin"]
["Methotrexate","E-Selectin",0,0,1,0,"SELE","17963163",2007,"Soluble cell adhesion molecules (sICAM-1, sVCAM-1, and sE-selectin) in patients with early rheumatoid arthritis.","17963163","Methotrexate","E-Selectin"]
["Methotrexate","Transforming Growth Factor beta1",0,0,1,1,"TGFB1","24646714",2014,"Involvement of epithelial-mesenchymal transition in methotrexate-induced pulmonary fibrosis.","24646714","Methotrexate","Transforming Growth Factor beta1"]
["Methotrexate","Tissue Inhibitor of Metalloproteinase-1",0,0,1,0,"TIMP1","10888709",2000,"Enhanced production of tissue inhibitor of metalloproteinases by peripheral blood mononuclear cells of rheumatoid arthritis patients responding to methotrexate treatment.","10888709","Methotrexate","Tissue Inhibitor of Metalloproteinase-1"]
["Methotrexate","Tissue Inhibitor of Metalloproteinase-1",0,0,1,1,"TIMP1","22220905",2012,"Deregulation of the CXCL12/CXCR4 axis in methotrexate chemotherapy-induced damage and recovery of the bone marrow microenvironment.","22220905","Methotrexate","Tissue Inhibitor of Metalloproteinase-1"]
["Methotrexate","Tissue Inhibitor of Metalloproteinase-1",0,0,1,0,"TIMP1","19487269",2009,"E-selectin, interleukin 18, serum amyloid a, and matrix metalloproteinase 9 are associated with clinical response to golimumab plus methotrexate in patients with active rheumatoid arthritis despite methotrexate therapy.","19487269","Methotrexate","Tissue Inhibitor of Metalloproteinase-1"]
["Methotrexate","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","23465067",2013,"Serum levels of lipoprotein(a) and E-selectin are reduced in rheumatoid arthritis patients treated with methotrexate or methotrexate in combination with TNF-?-inhibitor.","23465067","Methotrexate","Vascular Cell Adhesion Molecule-1"]
["Methotrexate","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","12890192",2003,"Methotrexate inhibits proliferation and regulation of the expression of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 by cultured human umbilical vein endothelial cells.","12890192","Methotrexate","Vascular Cell Adhesion Molecule-1"]
["Methotrexate","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","15009098",2004,"Altered tissue expression pattern of cell adhesion molecules, ICAM-1, E-selectin and VCAM-1, in bullous pemphigoid during methotrexate therapy.","15009098","Methotrexate","Vascular Cell Adhesion Molecule-1"]
["Methotrexate","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","17963163",2007,"Soluble cell adhesion molecules (sICAM-1, sVCAM-1, and sE-selectin) in patients with early rheumatoid arthritis.","17963163","Methotrexate","Vascular Cell Adhesion Molecule-1"]
["Methotrexate","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","11016854",2000,"Circulating levels of soluble E-selectin, ICAM-1 and VCAM-1 in bullous pemphigoid during low-dose methotrexate therapy. A prospective study.","11016854","Methotrexate","Vascular Cell Adhesion Molecule-1"]
["Methotrexate","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","15217363",2004,"Methotrexate markedly reduces the expression of vascular E-selectin, cutaneous lymphocyte-associated antigen and the numbers of mononuclear leucocytes in psoriatic skin.","15217363","Methotrexate","Vascular Cell Adhesion Molecule-1"]
["Methotrexate","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","16265686",2005,"Modification of pro- and antiinflammatory cytokines and vascular-related molecules by tumor necrosis factor-a blockade in patients with rheumatoid arthritis.","16265686","Methotrexate","Vascular Cell Adhesion Molecule-1"]
["Methoxychlor","Macrophage Colony-Stimulating Factor",0,0,1,1,"CSF1","15925024",2005,"Myelotoxicity in genistein-, nonylphenol-, methoxychlor-, vinclozolin- or ethinyl estradiol-exposed F1 generations of Sprague-Dawley rats following developmental and adult exposures.","15925024","Methoxychlor","Macrophage Colony-Stimulating Factor"]
["Methoxychlor","Receptor, Epidermal Growth Factor",0,0,1,1,"EGFR","8888411",1996,"Methoxychlor mimics the action of 17 beta-estradiol on induction of uterine epidermal growth factor receptors in immature female rats.","8888411","Methoxychlor","Receptor, Epidermal Growth Factor"]
["methyl bromide","Matrix Metalloproteinase 9",0,0,0,1,"MMP9","20530375",2010,"Matrix metalloproteinase-9 and -2 expression in the olfactory bulb following methyl bromide gas exposure.","20530375","methyl bromide","Matrix Metalloproteinase 9"]
["Mifepristone","Chemokine CCL2",0,0,1,0,"CCL2","18474108",2008,"RU486 did not exacerbate cytokine release in mice challenged with LPS nor in db/db mice.","18474108","Mifepristone","Chemokine CCL2"]
["Mifepristone","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","16412750",2006,"Expression of heparin-binding epidermal growth factor-like growth factor and its receptors in the human fallopian tube and endometrium after treatment with mifepristone.","16412750","Mifepristone","Receptor, Epidermal Growth Factor"]
["Mifepristone","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","7962464",1994,"Meningiomas, epidermal growth factor and progesterone.","7962464","Mifepristone","Receptor, Epidermal Growth Factor"]
["Mifepristone","Matrix Metalloproteinase 1",0,0,1,0,"MMP1","1843268",1991,"Effects of RU486 on the interstitial collagenase in the process of cervical ripening in the pregnant rat.","1843268","Mifepristone","Matrix Metalloproteinase 1"]
["Mifepristone","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","22587999",2012,"The nuclear factor-?B pathway is involved in matrix metalloproteinase-9 expression in RU486-induced endometrium breakdown in mice.","22587999","Mifepristone","Matrix Metalloproteinase 9"]
["Mifepristone","Matrix Metalloproteinase 9",0,0,1,1,"MMP9","24210229",2014,"Elevated expression levels of matrix metalloproteinase-9 in placental villi and tissue inhibitor of metalloproteinase-2 in decidua are associated with prolonged bleeding after mifepristone-misoprostol medical abortion.","24210229","Mifepristone","Matrix Metalloproteinase 9"]
["Mifepristone","Matrix Metalloproteinase 9",0,0,1,1,"MMP9","19353331",2009,"Abnormal expression of MMP-9 and imbalance of MMP-9/TIMP-1 is associated with prolonged uterine bleeding after a medical abortion with mifepristone and misoprostol.","19353331","Mifepristone","Matrix Metalloproteinase 9"]
["Mifepristone","NF-E2-Related Factor 2",0,0,1,0,"NFE2L2","21418903",2011,"[In vitro construction and confirmation of adenovirus containing a mifepristone (RU486)-inducible regulation system for NRF2 gene].","21418903","Mifepristone","NF-E2-Related Factor 2"]
["Mifepristone","NF-E2-Related Factor 2",0,0,1,0,"NFE2L2","22804935",2012,"[The effects of Nrf2 gene expression induced by RU486 at different doses on A549 cell damage induced by paraquat].","22804935","Mifepristone","NF-E2-Related Factor 2"]
["Mifepristone","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","11780441",2001,"Tissue-type plasminogen activator and plasminogen activator inhibitor type-1 mRNA and their protein expression levels in human decidua after early pregnancy termination by mifepristone plus misoprostol.","11780441","Mifepristone","Plasminogen Activator Inhibitor 1"]
["Mifepristone","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","7599699",1995,"Effects of steroid hormones on fibrinolytic system in cultured human endometrial cells.","7599699","Mifepristone","Plasminogen Activator Inhibitor 1"]
["Mifepristone","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","7714076",1995,"Biological mechanisms underlying the clinical effects of RU 486: modulation of cultured endometrial stromal cell plasminogen activator and plasminogen activator inhibitor expression.","7714076","Mifepristone","Plasminogen Activator Inhibitor 1"]
["Mifepristone","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","12429976",2002,"Mifepristone-induced secretion of transforming growth factor beta1-induced apoptosis in prostate cancer cells.","12429976","Mifepristone","Transforming Growth Factor beta1"]
["Mifepristone","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","15255629",2003,"Effect of early luteal phase administration of a single dose mifepristone on immunohistochemical distribution of interleukin 1 alpha (IL-1 alpha) and transforming growth factor beta 1 (TGF-beta 1) in mid-luteal phase ovary of the rhesus monkey.","15255629","Mifepristone","Transforming Growth Factor beta1"]
["Mifepristone","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","12851686",2003,"Induction of antiproliferation and apoptosis in estrogen receptor negative MDA-231 human breast cancer cells by mifepristone and 4-hydroxytamoxifen combination therapy: a role for TGFbeta1.","12851686","Mifepristone","Transforming Growth Factor beta1"]
["Mifepristone","Tissue Inhibitor of Metalloproteinase-1",0,0,1,1,"TIMP1","24210229",2014,"Elevated expression levels of matrix metalloproteinase-9 in placental villi and tissue inhibitor of metalloproteinase-2 in decidua are associated with prolonged bleeding after mifepristone-misoprostol medical abortion.","24210229","Mifepristone","Tissue Inhibitor of Metalloproteinase-1"]
["Mifepristone","Tissue Inhibitor of Metalloproteinase-1",0,0,1,1,"TIMP1","19353331",2009,"Abnormal expression of MMP-9 and imbalance of MMP-9/TIMP-1 is associated with prolonged uterine bleeding after a medical abortion with mifepristone and misoprostol.","19353331","Mifepristone","Tissue Inhibitor of Metalloproteinase-1"]
["Mifepristone","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","15922554",2005,"RU486 blocks the anti-inflammatory effects of exercise in a murine model of allergen-induced pulmonary inflammation.","15922554","Mifepristone","Vascular Cell Adhesion Molecule-1"]
["monomethylarsonic acid","NF-E2-Related Factor 2",1,1,0,1,"NFE2L2","17765279",2007,"Nrf2 protects human bladder urothelial cells from arsenite and monomethylarsonous acid toxicity.","17765279","monomethylarsonic acid","NF-E2-Related Factor 2"]
["naphthalene","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","23391364",2013,"Design, modification and 3D QSAR studies of novel naphthalin-containing pyrazoline derivatives with/without thiourea skeleton as anticancer agents.","23391364","naphthalene","Receptor, Epidermal Growth Factor"]
["naphthalene","Receptor, Epidermal Growth Factor",0,0,1,1,"EGFR","9250157",1997,"Distribution of epidermal growth factor receptor and ligands during bronchiolar epithelial repair from naphthalene-induced Clara cell injury in the mouse.","9250157","naphthalene","Receptor, Epidermal Growth Factor"]
["n-butoxyethanol","Vascular Cell Adhesion Molecule-1",1,0,1,1,"VCAM1","14703767",2003,"Ocular expression of vascular cell adhesion molecule (VCAM-1) in 2-butoxyethanol-induced hemolysis and thrombosis in female rats.","14703767","n-butoxyethanol","Vascular Cell Adhesion Molecule-1"]
["Nicotine","Chemokine CCL2",0,0,1,1,"CCL2","14522253",2003,"Second hand smoke stimulates tumor angiogenesis and growth.","14522253","Nicotine","Chemokine CCL2"]
["Nicotine","Chemokine CCL2",0,0,1,0,"CCL2","21494800",2012,"Nicotine induces pro-inflammatory response in aortic vascular smooth muscle cells through a NF?B/osteopontin amplification loop-dependent pathway.","21494800","Nicotine","Chemokine CCL2"]
["Nicotine","Chemokine CCL2",0,0,1,1,"CCL2","20579680",2010,"Induction of monocyte chemoattractant protein-1 by nicotine in pancreatic ductal adenocarcinoma cells: role of osteopontin.","20579680","Nicotine","Chemokine CCL2"]
["Nicotine","Chemokine CCL2",0,0,1,1,"CCL2","16332510",2006,"Nicotine modulation of cytokine induction by LPS-stimulated human monocytes and coronary artery endothelial cells.","16332510","Nicotine","Chemokine CCL2"]
["Nicotine","Chemokine CCL2",0,0,1,1,"CCL2","23748423",2013,"Nicotine potentiates proatherogenic effects of oxLDL by stimulating and upregulating macrophage CD36 signaling.","23748423","Nicotine","Chemokine CCL2"]
["Nicotine","Chemokine CCL2",0,0,1,0,"CCL2","15135227",2004,"Nicotine attenuates oxidative stress, activation of redox-regulated transcription factors and induction of proinflammatory genes in compressive spinal cord trauma.","15135227","Nicotine","Chemokine CCL2"]
["Nicotine","Chemokine CCL2",0,0,1,1,"CCL2","17335378",2007,"Nicotine and lipopolysaccharide affect cytokine expression from gingival fibroblasts.","17335378","Nicotine","Chemokine CCL2"]
["Nicotine","Chemokine CCL2",0,0,1,0,"CCL2","15976189",2005,"The diverse actions of nicotine and different extracted fractions from tobacco smoke against hapten-induced colitis in rats.","15976189","Nicotine","Chemokine CCL2"]
["Nicotine","Chemokine CCL2",0,0,1,0,"CCL2","24669857",2014,"Nicotine exaggerates LPS-induced airway hyperreactivity via JNK-mediated up-regulation of Toll-like receptor 4.","24669857","Nicotine","Chemokine CCL2"]
["Nicotine","Antigens, CD40",0,0,1,0,"CD40","12566374",2003,"Nicotine strongly activates dendritic cell-mediated adaptive immunity: potential role for progression of atherosclerotic lesions.","12566374","Nicotine","Antigens, CD40"]
["Nicotine","Antigens, CD40",0,0,1,0,"CD40","19955489",2010,"Effect of nicotine on advanced glycation end product-induced immune response in human monocytes.","19955489","Nicotine","Antigens, CD40"]
["Nicotine","Antigens, CD40",0,0,1,0,"CD40","22245993",2012,"Lipopolysaccharide and dose of nicotine determine the effects of nicotine             on murine bone marrow-derived dendritic cells.","22245993","Nicotine","Antigens, CD40"]
["Nicotine","Collagen Type III",0,0,1,0,"COL3A1","23125003",2013,"Nicotine reduced MMP-9 expression in the primary porcine tenocytes exposed to cyclic stretch.","23125003","Nicotine","Collagen Type III"]
["Nicotine","Macrophage Colony-Stimulating Factor",0,0,1,1,"CSF1","17342254",2007,"Lipopolysaccharide enhances the production of nicotine-induced prostaglandin E2 by an increase in cyclooxygenase-2 expression in osteoblasts.","17342254","Nicotine","Macrophage Colony-Stimulating Factor"]
["Nicotine","Macrophage Colony-Stimulating Factor",0,0,1,1,"CSF1","16266722",2006,"Nicotine and lipopolysaccharide stimulate the formation of osteoclast-like cells by increasing macrophage colony-stimulating factor and prostaglandin E2 production by osteoblasts.","16266722","Nicotine","Macrophage Colony-Stimulating Factor"]
["Nicotine","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","15164609",2004,"[Calcium signaling mediated by nicotine receptors in neurons].","15164609","Nicotine","Receptor, Epidermal Growth Factor"]
["Nicotine","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","17015027",2007,"Nicotine activates cell-signaling pathways through muscle-type and neuronal nicotinic acetylcholine receptors in non-small cell lung cancer cells.","17015027","Nicotine","Receptor, Epidermal Growth Factor"]
["Nicotine","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","10994639",2000,"Up-regulation of epidermal growth factor-receptors (EGF-R) by nicotine in cervical cancer cell lines: this effect may be mediated by EGF.","10994639","Nicotine","Receptor, Epidermal Growth Factor"]
["Nicotine","Receptor, Epidermal Growth Factor",0,0,1,1,"EGFR","22614999",2013,"Nicotine enhances proliferation, migration, and radioresistance of human malignant glioma cells through EGFR activation.","22614999","Nicotine","Receptor, Epidermal Growth Factor"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L1348,L1348)","v":"Nicotine"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M1348,M1348)","v":"Receptor, Epidermal Growth Factor"},0,0,1,0,"EGFR",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K1348,K1348)","v":"12472891"},2002,"Nicotine-induced phosphorylation of Akt through epidermal growth factor receptor and Src in PC12h cells.","12472891","Nicotine","Receptor, Epidermal Growth Factor"]
["Nicotine","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","14569062",2004,"Nicotine promoted colon cancer growth via epidermal growth factor receptor, c-Src, and 5-lipoxygenase-mediated signal pathway.","14569062","Nicotine","Receptor, Epidermal Growth Factor"]
["Nicotine","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","22085699",2011,"Sensitization of epithelial growth factor receptors by nicotine exposure to promote breast cancer cell growth.","22085699","Nicotine","Receptor, Epidermal Growth Factor"]
["Nicotine","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","17286987",2007,"Nicotine-induced vascular endothelial growth factor release via the EGFR-ERK pathway in rat vascular smooth muscle cells.","17286987","Nicotine","Receptor, Epidermal Growth Factor"]
["Nicotine","Receptor, Epidermal Growth Factor",0,0,1,1,"EGFR","18262213",2008,"Recurrent exposure to nicotine differentiates human bronchial epithelial cells via epidermal growth factor receptor activation.","18262213","Nicotine","Receptor, Epidermal Growth Factor"]
["Nicotine","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","1412511",1992,"Benzo[a]pyrene and nicotine impair epidermal growth factor mediated cellular functions of buccal mucosa.","1412511","Nicotine","Receptor, Epidermal Growth Factor"]
["Nicotine","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","23625155",2013,"Nicotine induces resistance to epidermal growth factor receptor tyrosine kinase inhibitor by ?1 nicotinic acetylcholine receptor-mediated activation in PC9 cells.","23625155","Nicotine","Receptor, Epidermal Growth Factor"]
["Nicotine","Receptor, Epidermal Growth Factor",0,0,1,1,"EGFR","8597029",1996,"Effects of in vivo treatments of nicotine and benzo[a]pyrene on the epidermal growth factor receptor in hamster buccal pouch.","8597029","Nicotine","Receptor, Epidermal Growth Factor"]
["Nicotine","Receptors, LDL",0,0,1,0,"LDLR","16254210",2006,"Nicotine induces proinflammatory responses in macrophages and the aorta leading to acceleration of atherosclerosis in low-density lipoprotein receptor(-/-) mice.","16254210","Nicotine","Receptors, LDL"]
["Nicotine","Receptors, LDL",0,0,1,0,"LDLR","24358207",2013,"Nicotine-induced expression of low-density lipoprotein receptor in oral epithelial cells.","24358207","Nicotine","Receptors, LDL"]
["Nicotine","Matrix Metalloproteinase 1",0,0,1,0,"MMP1","18986645",2009,"Effects of nicotine and lipopolysaccharide on the expression of matrix metalloproteinases, plasminogen activators, and their inhibitors in human osteoblasts.","18986645","Nicotine","Matrix Metalloproteinase 1"]
["Nicotine","Matrix Metalloproteinase 1",0,0,1,0,"MMP1","17151781",2006,"Nicotine treatment induces expression of matrix metalloproteinases in human osteoblastic Saos-2 cells.","17151781","Nicotine","Matrix Metalloproteinase 1"]
["Nicotine","Matrix Metalloproteinase 1",0,0,1,1,"MMP1","19660042",2009,"Effect of smoking, abstention, and nicotine patch on epidermal healing and collagenase in skin transudate.","19660042","Nicotine","Matrix Metalloproteinase 1"]
["Nicotine","Matrix Metalloproteinase 1",0,0,1,1,"MMP1","22489671",2012,"Endoplasmic reticulum stress modulates nicotine-induced extracellular matrix degradation in human periodontal ligament cells.","22489671","Nicotine","Matrix Metalloproteinase 1"]
["Nicotine","Matrix Metalloproteinase 9",0,0,1,1,"MMP9","22489671",2012,"Endoplasmic reticulum stress modulates nicotine-induced extracellular matrix degradation in human periodontal ligament cells.","22489671","Nicotine","Matrix Metalloproteinase 9"]
["Nicotine","Matrix Metalloproteinase 9",0,0,1,1,"MMP9","18412948",2008,"The influence of nicotine on granulocytic differentiation - inhibition of the oxidative burst and bacterial killing and increased matrix metalloproteinase-9 release.","18412948","Nicotine","Matrix Metalloproteinase 9"]
["Nicotine","Matrix Metalloproteinase 9",0,0,1,1,"MMP9","19879865",2010,"Evidence for the involvement of matrix metalloproteinases in the cardiovascular effects produced by nicotine.","19879865","Nicotine","Matrix Metalloproteinase 9"]
["Nicotine","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","22571166",2012,"Nicotine and lipopolysaccharide stimulate the production of MMPs and prostaglandin E2 by hypoxia-inducible factor-1? up-regulation in human periodontal ligament cells.","22571166","Nicotine","Matrix Metalloproteinase 9"]
["Nicotine","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","21723775",2011,"Chronic exposure to cigarette smoke increases matrix metalloproteinases and Filaggrin mRNA expression in oral keratinocytes: role of nicotine stimulation.","21723775","Nicotine","Matrix Metalloproteinase 9"]
["Nicotine","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","20923448",2011,"Nicotine modulates gelatinase B (MMP-9) and epilysin (MMP-28) expression in reconstituted human oral epithelium.","20923448","Nicotine","Matrix Metalloproteinase 9"]
["Nicotine","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","20824368",2010,"Involvement of osteopontin in the matrix-degrading and proangiogenic changes mediated by nicotine in pancreatic cancer cells.","20824368","Nicotine","Matrix Metalloproteinase 9"]
["Nicotine","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","23555029",2013,"Nicotine affects bone resorption and suppresses the expression of cathepsin K, MMP-9 and vacuolar-type H(+)-ATPase d2 and actin organization in osteoclasts.","23555029","Nicotine","Matrix Metalloproteinase 9"]
["Nicotine","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","14691189",2004,"Nicotine increases size and severity of experimental choroidal neovascularization.","14691189","Nicotine","Matrix Metalloproteinase 9"]
["Nicotine","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","19602125",2009,"Up-regulation of osteolytic mediators in human osteosarcoma cells stimulated with nicotine.","19602125","Nicotine","Matrix Metalloproteinase 9"]
["Nicotine","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","16317086",2005,"Nicotine induces cyclooxygenase-2 and vascular endothelial growth factor receptor-2 in association with tumor-associated invasion and angiogenesis in gastric cancer.","16317086","Nicotine","Matrix Metalloproteinase 9"]
["Nicotine","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","20347467",2010,"Effect of smoking, smoking cessation, and nicotine patch on wound dimension, vitamin C, and systemic markers of collagen metabolism.","20347467","Nicotine","Matrix Metalloproteinase 9"]
["Nicotine","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","23125003",2013,"Nicotine reduced MMP-9 expression in the primary porcine tenocytes exposed to cyclic stretch.","23125003","Nicotine","Matrix Metalloproteinase 9"]
["Nicotine","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","22529515",2012,"Pathogenesis of abdominal aortic aneurysms: role of nicotine and nicotinic acetylcholine receptors.","22529515","Nicotine","Matrix Metalloproteinase 9"]
["Nicotine","Matrix Metalloproteinase 9",0,0,1,1,"MMP9","20554619",2011,"The ?7-nicotinic acetylcholine receptor and MMP-2/-9 pathway mediate the proangiogenic effect of nicotine in human retinal endothelial cells.","20554619","Nicotine","Matrix Metalloproteinase 9"]
["Nicotine","Matrix Metalloproteinase 9",0,0,1,1,"MMP9","23192463",2013,"Differential responses of hippocampal neurons and astrocytes to nicotine and hypoxia in the fetal guinea pig.","23192463","Nicotine","Matrix Metalloproteinase 9"]
["Nicotine","Matrix Metalloproteinase 9",0,0,1,1,"MMP9","20448088",2010,"Nicotine alters morphology and function of retinal pigment epithelial cells in mice.","20448088","Nicotine","Matrix Metalloproteinase 9"]
["Nicotine","NF-E2-Related Factor 2",0,0,1,1,"NFE2L2","23822755",2013,"Tobacco smoking effect on HIV-1 pathogenesis: role of cytochrome P450 isozymes.","23822755","Nicotine","NF-E2-Related Factor 2"]
["Nicotine","NF-E2-Related Factor 2",0,0,1,1,"NFE2L2","19656028",2009,"Effects of nicotine on antioxidant defense enzymes and RANKL expression in human periodontal ligament cells.","19656028","Nicotine","NF-E2-Related Factor 2"]
["Nicotine","NF-E2-Related Factor 2",0,0,1,0,"NFE2L2","21083424",2011,"Stimulation of alpha7 nicotinic acetylcholine receptor by nicotine attenuates inflammatory response in macrophages and improves survival in experimental model of sepsis through heme oxygenase-1 induction.","21083424","Nicotine","NF-E2-Related Factor 2"]
["Nicotine","Receptors, Urokinase Plasminogen Activator",0,0,1,0,"PLAUR","16317086",2005,"Nicotine induces cyclooxygenase-2 and vascular endothelial growth factor receptor-2 in association with tumor-associated invasion and angiogenesis in gastric cancer.","16317086","Nicotine","Receptors, Urokinase Plasminogen Activator"]
["Nicotine","Receptors, Urokinase Plasminogen Activator",0,0,1,0,"PLAUR","22261521",2012,"Nicotine stimulates urokinase-type plasminogen activator receptor expression and cell invasiveness through mitogen-activated protein kinase and reactive oxygen species signaling in ECV304 endothelial cells.","22261521","Nicotine","Receptors, Urokinase Plasminogen Activator"]
["Nicotine","E-Selectin",0,0,1,0,"SELE","22240023",2012,"Nicotine-mediated induction of E-selectin in aortic endothelial cells requires Src kinase and E2F1 transcriptional activity.","22240023","Nicotine","E-Selectin"]
["Nicotine","E-Selectin",0,0,1,0,"SELE","15454119",2004,"Nicotine could augment adhesion molecule expression in human endothelial cells through macrophages secreting TNF-alpha, IL-1beta.","15454119","Nicotine","E-Selectin"]
["Nicotine","E-Selectin",0,0,1,0,"SELE","17177960",2007,"Nicotine exposure alters in vivo human responses to endotoxin.","17177960","Nicotine","E-Selectin"]
["Nicotine","E-Selectin",0,0,1,0,"SELE","16644474",2006,"Estrogen down-regulates nicotine-induced adhesion molecule expression via nongenomic signal pathway in endothelial cells.","16644474","Nicotine","E-Selectin"]
["Nicotine","E-Selectin",0,0,1,0,"SELE","16257255",2006,"Nicotine stimulates adhesion molecular expression via calcium influx and mitogen-activated protein kinases in human endothelial cells.","16257255","Nicotine","E-Selectin"]
["Nicotine","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","10066866",1999,"Nicotine increases plasminogen activator inhibitor-1 production by human brain endothelial cells via protein kinase C-associated pathway.","10066866","Nicotine","Plasminogen Activator Inhibitor 1"]
["Nicotine","Plasminogen Activator Inhibitor 1",0,0,1,1,"SERPINE1","21781517",2011,"[Interaction of protein kinase C-extracellular signal-regulated kinase 1/2 signal pathway in the process of plasminogen activator inhibitor-1 expression induced by nicotine in human umbilical vein endothelial cells].","21781517","Nicotine","Plasminogen Activator Inhibitor 1"]
["Nicotine","Plasminogen Activator Inhibitor 1",0,0,1,1,"SERPINE1","11166759",2001,"Nicotine induced changes in gene expression by human coronary artery endothelial cells.","11166759","Nicotine","Plasminogen Activator Inhibitor 1"]
["Nicotine","Plasminogen Activator Inhibitor 1",0,0,1,1,"SERPINE1","9040492",1997,"Chronic nicotine treatment enhances focal ischemic brain injury and depletes free pool of brain microvascular tissue plasminogen activator in rats.","9040492","Nicotine","Plasminogen Activator Inhibitor 1"]
["Nicotine","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","20050989",2010,"Beneficial effects of melatonin on nicotine-induced vasculopathy.","20050989","Nicotine","Transforming Growth Factor beta1"]
["Nicotine","Transforming Growth Factor beta1",0,0,1,1,"TGFB1","20307763",2010,"Effect of nicotine on gene expression of angiogenic and osteogenic factors in a rabbit model of bone regeneration.","20307763","Nicotine","Transforming Growth Factor beta1"]
["Nicotine","Transforming Growth Factor beta1",0,0,1,1,"TGFB1","22169004",2012,"A novel U-STAT3-dependent mechanism mediates the deleterious effects of chronic nicotine exposure on renal injury.","22169004","Nicotine","Transforming Growth Factor beta1"]
["Nicotine","Transforming Growth Factor beta1",0,0,1,1,"TGFB1","22906950",2012,"General mechanisms of nicotine-induced fibrogenesis.","22906950","Nicotine","Transforming Growth Factor beta1"]
["Nicotine","Transforming Growth Factor beta1",0,0,1,1,"TGFB1","22108052",2012,"Nicotine induces fibrogenic changes in human liver via nicotinic acetylcholine receptors expressed on hepatic stellate cells.","22108052","Nicotine","Transforming Growth Factor beta1"]
["Nicotine","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","15962330",2005,"Nicotine inhibits myofibroblast differentiation in human gingival fibroblasts.","15962330","Nicotine","Transforming Growth Factor beta1"]
["Nicotine","Transforming Growth Factor beta1",0,0,1,1,"TGFB1","20971543",2011,"Effect of platelet-rich plasma on a rabbit model of nicotine-compromised bone healing.","20971543","Nicotine","Transforming Growth Factor beta1"]
["Nicotine","Transforming Growth Factor beta1",0,0,1,1,"TGFB1","18973546",2009,"Nicotinic acetylcholine receptor activation mediates nicotine-induced enhancement of experimental periodontitis.","18973546","Nicotine","Transforming Growth Factor beta1"]
["Nicotine","Transforming Growth Factor beta1",0,0,1,1,"TGFB1","19502283",2009,"Nicotine, atrial fibrosis, and atrial fibrillation: do microRNAs help to clear the smoke?","19502283","Nicotine","Transforming Growth Factor beta1"]
["Nicotine","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","20843956",2010,"Stimulation of ?7 nicotinic acetylcholine receptor by nicotine increases suppressive capacity of naturally occurring CD4+CD25+ regulatory T cells in mice in vitro.","20843956","Nicotine","Transforming Growth Factor beta1"]
["Nicotine","Transforming Growth Factor beta1",0,0,1,1,"TGFB1","22691361",2012,"Developmental nicotine exposure results in programming of alveolar simplification and interstitial pulmonary fibrosis in adult male rats.","22691361","Nicotine","Transforming Growth Factor beta1"]
["Nicotine","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","23204070",2013,"Nicotine-induced epithelial-mesenchymal transition via Wnt/?-catenin signaling in human airway epithelial cells.","23204070","Nicotine","Transforming Growth Factor beta1"]
["Nicotine","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","18060582",2008,"Potentiation of HIV-1 expression in microglial cells by nicotine: involvement of transforming growth factor-beta 1.","18060582","Nicotine","Transforming Growth Factor beta1"]
["Nicotine","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","19453497",2009,"Nicotinic acetylcholine receptor activation mediates nicotine-induced enhancement of experimental periodontitis.","19453497","Nicotine","Transforming Growth Factor beta1"]
["Nicotine","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","24201082",2013,"Nicotine effect on inflammatory and growth factor responses in murine cutaneous wound healing.","24201082","Nicotine","Transforming Growth Factor beta1"]
["Nicotine","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","17657162",2007,"HMG-CoA reductase inhibitors reduce nicotine-induced expression of cellular adhesion molecules in cultured human coronary endothelial cells.","17657162","Nicotine","Vascular Cell Adhesion Molecule-1"]
["Nicotine","Vascular Cell Adhesion Molecule-1",0,0,1,1,"VCAM1","11166759",2001,"Nicotine induced changes in gene expression by human coronary artery endothelial cells.","11166759","Nicotine","Vascular Cell Adhesion Molecule-1"]
["Nicotine","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","15354631",2004,"Nicotine induces mononuclear leukocyte adhesion and expression of adhesion molecules, VCAM and ICAM, in endothelial cells in vitro.","15354631","Nicotine","Vascular Cell Adhesion Molecule-1"]
["Nicotine","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","20162355",2010,"HUVEC ICAM-1 and VCAM-1 synthesis in response to potentially athero-prone and athero-protective mechanical and nicotine chemical stimuli.","20162355","Nicotine","Vascular Cell Adhesion Molecule-1"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L1412,L1412)","v":"Nicotine"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M1412,M1412)","v":"Vascular Cell Adhesion Molecule-1"},0,0,1,0,"VCAM1",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K1412,K1412)","v":"16845181"},2006,"Nicotine enhances human vascular endothelial cell expression of ICAM-1 and VCAM-1 via protein kinase C, p38 mitogen-activated protein kinase, NF-kappaB, and AP-1.","16845181","Nicotine","Vascular Cell Adhesion Molecule-1"]
["Nicotine","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","16257255",2006,"Nicotine stimulates adhesion molecular expression via calcium influx and mitogen-activated protein kinases in human endothelial cells.","16257255","Nicotine","Vascular Cell Adhesion Molecule-1"]
["Nicotine","Vascular Cell Adhesion Molecule-1",0,0,1,1,"VCAM1","19247191",2009,"Inhibitory effect of ghrelin on nicotine-induced VCAM-1 expression in human umbilical vein endothelial cells.","19247191","Nicotine","Vascular Cell Adhesion Molecule-1"]
["Nicotine","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","15454119",2004,"Nicotine could augment adhesion molecule expression in human endothelial cells through macrophages secreting TNF-alpha, IL-1beta.","15454119","Nicotine","Vascular Cell Adhesion Molecule-1"]
["Nicotine","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","16644474",2006,"Estrogen down-regulates nicotine-induced adhesion molecule expression via nongenomic signal pathway in endothelial cells.","16644474","Nicotine","Vascular Cell Adhesion Molecule-1"]
["Nicotine","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","18472096",2008,"Nicotine promotes contribution of bone marrow-derived cells to experimental choroidal neovascularization in mice.","18472096","Nicotine","Vascular Cell Adhesion Molecule-1"]
["Nicotine","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","20050989",2010,"Beneficial effects of melatonin on nicotine-induced vasculopathy.","20050989","Nicotine","Vascular Cell Adhesion Molecule-1"]
["Nicotine","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","16254210",2006,"Nicotine induces proinflammatory responses in macrophages and the aorta leading to acceleration of atherosclerosis in low-density lipoprotein receptor(-/-) mice.","16254210","Nicotine","Vascular Cell Adhesion Molecule-1"]
["Nicotine","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","17384961",2007,"Distinct effects of acute and chronic nicotine application on microvascular thrombus formation and endothelial function in male and female mice.","17384961","Nicotine","Vascular Cell Adhesion Molecule-1"]
["nonylphenol","Macrophage Colony-Stimulating Factor",0,0,0,1,"CSF1","15925024",2005,"Myelotoxicity in genistein-, nonylphenol-, methoxychlor-, vinclozolin- or ethinyl estradiol-exposed F1 generations of Sprague-Dawley rats following developmental and adult exposures.","15925024","nonylphenol","Macrophage Colony-Stimulating Factor"]
["nonylphenol","Chemokine CXCL10",0,0,0,0,"CXCL10","19756997",2010,"Suppressive effect on MDC and IP-10 expression in monocytes by endocrine disruptor chemicals.","19756997","nonylphenol","Chemokine CXCL10"]
["Oxytetracycline","Matrix Metalloproteinase 1",0,0,1,0,"MMP1","15077693",2004,"In vitro effects of oxytetracycline on matrix metalloproteinase-1 mRNA expression and on collagen gel contraction by cultured myofibroblasts obtained from the accessory ligament of foals.","15077693","Oxytetracycline","Matrix Metalloproteinase 1"]
["Oxytetracycline","Matrix Metalloproteinase 1",0,0,1,0,"MMP1","15077693",2004,"In vitro effects of oxytetracycline on matrix metalloproteinase-1 mRNA expression and on collagen gel contraction by cultured myofibroblasts obtained from the accessory ligament of foals.","15077693","Oxytetracycline","Matrix Metalloproteinase 1"]
["Paraquat","Collagen Type III",1,0,0,1,"COL3A1","23433149",2013,"[Intervention of pyrrolidine dithiocarbamate on expressions of connective tissue growth factor, type I collagen, and type III collage in acute paraquat poisoned rats].","23433149","Paraquat","Collagen Type III"]
["Paraquat","Collagen Type III",1,0,0,1,"COL3A1","23427393",2012,"Therapeutic potential of intravenous Xuebijing on transforming growth factor beta1 and procollagen type III peptide in patients with acute paraquat poisoning.","23427393","Paraquat","Collagen Type III"]
["Paraquat","Collagen Type III",1,0,0,1,"COL3A1","23240748",2012,"Paraquat-induced pulmonary fibrosis starts at an early stage of inflammation in rats.","23240748","Paraquat","Collagen Type III"]
["Paraquat","Chemokine CXCL10",1,0,0,0,"CXCL10","22230393",2011,"Effects of paraquat and capsaicin on the expression of genes related to inflammatory, immune responses and cell death in immortalized human HaCat keratinocytes.","22230393","Paraquat","Chemokine CXCL10"]
["Paraquat","Matrix Metalloproteinase 9",1,0,0,1,"MMP9","22801080",2012,"[Effects of hemoperfusion on oxidative stress, matrix metalloproteinases and their inhibitors in acute paraquat poisoning rabbits].","22801080","Paraquat","Matrix Metalloproteinase 9"]
["Paraquat","Matrix Metalloproteinase 9",1,0,0,0,"MMP9","22230393",2011,"Effects of paraquat and capsaicin on the expression of genes related to inflammatory, immune responses and cell death in immortalized human HaCat keratinocytes.","22230393","Paraquat","Matrix Metalloproteinase 9"]
["Paraquat","Matrix Metalloproteinase 9",1,0,0,1,"MMP9","18630695",2008,"[Study on the expression of matrix metalloproteinase-9 in lung fibroblasts of rat with acute paraquat poisoning].","18630695","Paraquat","Matrix Metalloproteinase 9"]
["Paraquat","NF-E2-Related Factor 2",1,0,0,1,"NFE2L2","24755084",2014,"Protective effects of exogenous ?-hydroxybutyrate on paraquat toxicity in rat kidney.","24755084","Paraquat","NF-E2-Related Factor 2"]
["Paraquat","NF-E2-Related Factor 2",1,0,0,1,"NFE2L2","17823202",2007,"Paraquat induces dopaminergic dysfunction and proteasome impairment in DJ-1-deficient mice.","17823202","Paraquat","NF-E2-Related Factor 2"]
["Paraquat","NF-E2-Related Factor 2",1,0,0,1,"NFE2L2","22736252",2012,"Recombinant adenovirus Ad-RUNrf2 reduces paraquat-induced A549 injury.","22736252","Paraquat","NF-E2-Related Factor 2"]
["Paraquat","NF-E2-Related Factor 2",1,0,0,1,"NFE2L2","20851755",2010,"Paraquat induces cyclooxygenase-2 (COX-2) implicated toxicity in human neuroblastoma SH-SY5Y cells.","20851755","Paraquat","NF-E2-Related Factor 2"]
["Paraquat","NF-E2-Related Factor 2",1,0,0,1,"NFE2L2","22678742",2012,"Paraquat induces lung alveolar epithelial cell apoptosis via Nrf-2-regulated mitochondrial dysfunction and ER stress.","22678742","Paraquat","NF-E2-Related Factor 2"]
["Paraquat","NF-E2-Related Factor 2",1,0,0,1,"NFE2L2","22996356",2013,"Quercetin reduces oxidative damage induced by paraquat via modulating expression of antioxidant genes in A549 cells.","22996356","Paraquat","NF-E2-Related Factor 2"]
["Paraquat","NF-E2-Related Factor 2",1,0,0,0,"NFE2L2","22493042",2012,"Resveratrol inhibits paraquat-induced oxidative stress and fibrogenic response by activating the nuclear factor erythroid 2-related factor 2 pathway.","22493042","Paraquat","NF-E2-Related Factor 2"]
["Paraquat","NF-E2-Related Factor 2",1,0,0,1,"NFE2L2","22983789",2012,"Neuroprotective effects of tert-butylhydroquinone on paraquat-induced dopaminergic cell degeneration in C57BL/6 mice and in PC12 cells.","22983789","Paraquat","NF-E2-Related Factor 2"]
["Paraquat","NF-E2-Related Factor 2",1,0,0,1,"NFE2L2","24141985",2013,"Cytoprotective effect of bioactive sea buckthorn extract on paraquat-exposed A549 cells via induction of Nrf2 and its downstream genes.","24141985","Paraquat","NF-E2-Related Factor 2"]
["Paraquat","NF-E2-Related Factor 2",1,0,0,1,"NFE2L2","24866057",2014,"Hydrogen peroxide responsive miR153 targets Nrf2/ARE cytoprotection in paraquat induced dopaminergic neurotoxicity.","24866057","Paraquat","NF-E2-Related Factor 2"]
["Paraquat","NF-E2-Related Factor 2",1,0,0,1,"NFE2L2","23954820",2013,"The reversal of paraquat-induced mitochondria-mediated apoptosis by cycloartenyl ferulate, the important role of Nrf2 pathway.","23954820","Paraquat","NF-E2-Related Factor 2"]
["Paraquat","NF-E2-Related Factor 2",1,0,0,1,"NFE2L2","21972102",2012,"Standardized extracts of Bacopa monniera protect against MPP+- and paraquat-induced toxicity by modulating mitochondrial activities, proteasomal functions, and redox pathways.","21972102","Paraquat","NF-E2-Related Factor 2"]
["Paraquat","NF-E2-Related Factor 2",1,0,0,1,"NFE2L2","23933652",2013,"Inhibitory effects of rosiglitazone on paraquat-induced acute lung injury in rats.","23933652","Paraquat","NF-E2-Related Factor 2"]
["Paraquat","NF-E2-Related Factor 2",1,0,0,1,"NFE2L2","22804935",2012,"[The effects of Nrf2 gene expression induced by RU486 at different doses on A549 cell damage induced by paraquat].","22804935","Paraquat","NF-E2-Related Factor 2"]
["Paraquat","NF-E2-Related Factor 2",1,0,0,1,"NFE2L2","21402726",2011,"Maneb and paraquat-mediated neurotoxicity: involvement of peroxiredoxin/thioredoxin system.","21402726","Paraquat","NF-E2-Related Factor 2"]
["Paraquat","Plasminogen Activator Inhibitor 1",1,0,0,1,"SERPINE1","21468253",2011,"Tissue plasminogen activator and plasminogen activator inhibitor-1 levels in patients with acute paraquat intoxication.","21468253","Paraquat","Plasminogen Activator Inhibitor 1"]
["Paraquat","Transforming Growth Factor beta1",1,0,0,1,"TGFB1","19272247",2008,"[Influence of pyrrolidine dithiocarbamate (PDTC) on expression of transforming growth factor beta(1), matrix metalloproteinase-2 and tissue inhibitor-1 of metalloproteinase in rats with pulmonary damage induced by paraquat].","19272247","Paraquat","Transforming Growth Factor beta1"]
["Paraquat","Transforming Growth Factor beta1",1,0,0,1,"TGFB1","23590892",2013,"Docosahexaenoic acid (DHA) ameliorates paraquat-induced pulmonary fibrosis in rats possibly through up-regulation of Smad 7 and SnoN.","23590892","Paraquat","Transforming Growth Factor beta1"]
["Paraquat","Transforming Growth Factor beta1",1,0,0,1,"TGFB1","24535699",2014,"Effect of transforming growth factor-?1 on acute lung injury caused by paraquat.","24535699","Paraquat","Transforming Growth Factor beta1"]
["Paraquat","Transforming Growth Factor beta1",1,0,0,1,"TGFB1","20498031",2011,"Role of growth factors in acute lung injury induced by paraquat in a rat model.","20498031","Paraquat","Transforming Growth Factor beta1"]
["Paraquat","Transforming Growth Factor beta1",1,0,0,0,"TGFB1","23864800",2013,"The dose of cyclophosphamide for treating paraquat-induced rat lung injury.","23864800","Paraquat","Transforming Growth Factor beta1"]
["Paraquat","Transforming Growth Factor beta1",1,0,0,1,"TGFB1","17720326",2008,"Anti-TGF-beta1 antibody: an effective treatment for lung injury caused by paraquat in the future.","17720326","Paraquat","Transforming Growth Factor beta1"]
["Paraquat","Transforming Growth Factor beta1",1,0,0,1,"TGFB1","24155875",2013,"Using bosentan to treat paraquat poisoning-induced acute lung injury in rats.","24155875","Paraquat","Transforming Growth Factor beta1"]
["Paraquat","Transforming Growth Factor beta1",1,0,0,1,"TGFB1","20095326",2009,"[Changes of cytokine and nuclear factor-kappa B in acute paraquat poisoned rats].","20095326","Paraquat","Transforming Growth Factor beta1"]
["Paraquat","Transforming Growth Factor beta1",1,0,0,0,"TGFB1","22493042",2012,"Resveratrol inhibits paraquat-induced oxidative stress and fibrogenic response by activating the nuclear factor erythroid 2-related factor 2 pathway.","22493042","Paraquat","Transforming Growth Factor beta1"]
["Paraquat","Transforming Growth Factor beta1",1,0,0,1,"TGFB1","23427393",2012,"Therapeutic potential of intravenous Xuebijing on transforming growth factor beta1 and procollagen type III peptide in patients with acute paraquat poisoning.","23427393","Paraquat","Transforming Growth Factor beta1"]
["Paraquat","Transforming Growth Factor beta1",1,0,0,1,"TGFB1","22581813",2012,"Effects of RNA interference-induced Smad3 gene silencing on pulmonary fibrosis caused by paraquat in mice.","22581813","Paraquat","Transforming Growth Factor beta1"]
["Paraquat","Transforming Growth Factor beta1",1,0,0,1,"TGFB1","19969051",2010,"Chymase mediates paraquat-induced collagen production in human lung fibroblasts.","19969051","Paraquat","Transforming Growth Factor beta1"]
["Paraquat","Thrombomodulin",1,0,0,1,"THBD","20095324",2009,"[Expression of thrombomodulin, endothelial protein C receptor in lung tissue of acute paraquat poisoned rats and intervention of sodium dimercaptopropane sulfonate].","20095324","Paraquat","Thrombomodulin"]
["Paraquat","Tissue Inhibitor of Metalloproteinase-1",1,0,0,1,"TIMP1","11746190",2001,"Changes in concentrations of type IV collagen and tissue inhibitor of metalloproteinase-1 in patients with paraquat poisoning.","11746190","Paraquat","Tissue Inhibitor of Metalloproteinase-1"]
["Paraquat","Tissue Inhibitor of Metalloproteinase-1",1,0,0,1,"TIMP1","22801080",2012,"[Effects of hemoperfusion on oxidative stress, matrix metalloproteinases and their inhibitors in acute paraquat poisoning rabbits].","22801080","Paraquat","Tissue Inhibitor of Metalloproteinase-1"]
["Paraquat","Tissue Inhibitor of Metalloproteinase-1",1,0,0,1,"TIMP1","19272247",2008,"[Influence of pyrrolidine dithiocarbamate (PDTC) on expression of transforming growth factor beta(1), matrix metalloproteinase-2 and tissue inhibitor-1 of metalloproteinase in rats with pulmonary damage induced by paraquat].","19272247","Paraquat","Tissue Inhibitor of Metalloproteinase-1"]
["Pentachlorophenol","NF-E2-Related Factor 2",1,1,1,1,"NFE2L2","16352618",2006,"A crucial role of Nrf2 in in vivo defense against oxidative damage by an environmental pollutant, pentachlorophenol.","16352618","Pentachlorophenol","NF-E2-Related Factor 2"]
["perfluorooctane sulfonic acid","Matrix Metalloproteinase 9",0,0,1,1,"MMP9","21075133",2011,"In vitro evaluation of the immunotoxic potential of perfluorinated compounds (PFCs).","21075133","perfluorooctane sulfonic acid","Matrix Metalloproteinase 9"]
["perfluorooctane sulfonic acid","NF-E2-Related Factor 2",0,0,1,1,"NFE2L2","20200220",2010,"The role of Nrf2 and MAPK pathways in PFOS-induced oxidative stress in zebrafish embryos.","20200220","perfluorooctane sulfonic acid","NF-E2-Related Factor 2"]
["perfluorooctanoic acid","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","24960061",2014,"Perfluorooctanoic acid stimulates breast cancer cells invasion and up-regulates matrix metalloproteinase-2/-9 expression mediated by activating NF-?B.","24960061","perfluorooctanoic acid","Matrix Metalloproteinase 9"]
["perfluorooctanoic acid","Matrix Metalloproteinase 9",1,0,1,1,"MMP9","21075133",2011,"In vitro evaluation of the immunotoxic potential of perfluorinated compounds (PFCs).","21075133","perfluorooctanoic acid","Matrix Metalloproteinase 9"]
["perfluorooctanoic acid","NF-E2-Related Factor 2",1,0,1,1,"NFE2L2","18703564",2008,"Critical role of PPAR-alpha in perfluorooctanoic acid- and perfluorodecanoic acid-induced downregulation of Oatp uptake transporters in mouse livers.","18703564","perfluorooctanoic acid","NF-E2-Related Factor 2"]
["perfluorooctanoic acid","NF-E2-Related Factor 2",1,0,1,0,"NFE2L2","19616056",2009,"Perfluorooctanoic acid stimulated mitochondrial biogenesis and gene transcription in rats.","19616056","perfluorooctanoic acid","NF-E2-Related Factor 2"]
["perfluorooctanoic acid","NF-E2-Related Factor 2",1,0,1,1,"NFE2L2","18757529",2008,"Nrf2- and PPAR alpha-mediated regulation of hepatic Mrp transporters after exposure to perfluorooctanoic acid and perfluorodecanoic acid.","18757529","perfluorooctanoic acid","NF-E2-Related Factor 2"]
["Permethrin","NF-E2-Related Factor 2",0,0,0,1,"NFE2L2","23566817",2013,"Early life permethrin exposure induces long-term brain changes in Nurr1, NF-kB and Nrf-2.","23566817","Permethrin","NF-E2-Related Factor 2"]
["Permethrin","NF-E2-Related Factor 2",0,0,0,1,"NFE2L2","22804098",2012,"Leukocyte Nurr1 as peripheral biomarker of early-life environmental exposure to permethrin insecticide.","22804098","Permethrin","NF-E2-Related Factor 2"]
["Phenobarbital","Receptor, Epidermal Growth Factor",0,0,0,1,"EGFR","11062166",2000,"Potentiation of epidermal growth factor-induced DNA synthesis in rat hepatocytes by phenobarbitone: possible involvement of oxidative stress and kinase activation.","11062166","Phenobarbital","Receptor, Epidermal Growth Factor"]
["Phenobarbital","Receptor, Epidermal Growth Factor",0,0,0,0,"EGFR","3257910",1988,"Phenobarbital reduces EGF receptors and the ability of physiological concentrations of calcium to suppress hepatocyte proliferation.","3257910","Phenobarbital","Receptor, Epidermal Growth Factor"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L1476,L1476)","v":"Phenobarbital"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M1476,M1476)","v":"Receptor, Epidermal Growth Factor"},0,0,0,0,"EGFR",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K1476,K1476)","v":"3257714"},1988,"Modulation of epidermal growth factor receptors in rat hepatocytes by two liver tumor-promoting regimens, a choline-deficient and a phenobarbital diet.","3257714","Phenobarbital","Receptor, Epidermal Growth Factor"]
["Phenobarbital","Receptor, Epidermal Growth Factor",0,0,0,0,"EGFR","23652203",2013,"Phenobarbital indirectly activates the constitutive active androstane receptor (CAR) by inhibition of epidermal growth factor receptor signaling.","23652203","Phenobarbital","Receptor, Epidermal Growth Factor"]
["Phenobarbital","Receptor, Epidermal Growth Factor",0,0,0,0,"EGFR","10403793",1999,"EGF-Induced receptor autophosphorylation in primary hepatocytes isolated from phenobarbitone-treated mice.","10403793","Phenobarbital","Receptor, Epidermal Growth Factor"]
["Phenobarbital","Receptor, Epidermal Growth Factor",0,0,0,0,"EGFR","2790804",1989,"Independent mechanisms for tumor promoters phenobarbital and 12-O-tetradecanoylphorbol-13-acetate in reduction of epidermal growth factor binding by rat hepatocytes.","2790804","Phenobarbital","Receptor, Epidermal Growth Factor"]
["Phenobarbital","Receptor, Epidermal Growth Factor",0,0,0,0,"EGFR","2784053",1989,"Phenobarbital decreases hepatocyte EGF receptor expression independent of protein kinase C activation.","2784053","Phenobarbital","Receptor, Epidermal Growth Factor"]
["Phenobarbital","Receptor, Epidermal Growth Factor",0,0,0,1,"EGFR","1473236",1992,"Inhibition of DNA synthesis by phenobarbital in primary cultures of hepatocytes from normal rat liver and from hepatic nodules.","1473236","Phenobarbital","Receptor, Epidermal Growth Factor"]
["Phenobarbital","Receptor, Epidermal Growth Factor",0,0,0,0,"EGFR","10385683",1999,"Mimicry in primary rat hepatocyte cultures of the in vivo perivenous induction by phenobarbital of cytochrome P-450 2B1 mRNA: role of epidermal growth factor and perivenous oxygen tension.","10385683","Phenobarbital","Receptor, Epidermal Growth Factor"]
["Phenobarbital","Receptor, Epidermal Growth Factor",0,0,0,0,"EGFR","3008725",1986,"Chronic treatment with phenobarbital decreases the expression of rat liver EGF and insulin receptors.","3008725","Phenobarbital","Receptor, Epidermal Growth Factor"]
["Phenobarbital","Receptor, Epidermal Growth Factor",0,0,0,0,"EGFR","1988078",1991,"Reversible and phorbol ester-specific defect of protein kinase C translocation in hepatocytes isolated from phenobarbital-treated rats.","1988078","Phenobarbital","Receptor, Epidermal Growth Factor"]
["Phenobarbital","Receptor, Epidermal Growth Factor",0,0,0,0,"EGFR","3335004",1988,"Expression of endogenous retrovirus-like sequences and cellular oncogenes during phenobarbital treatment and regeneration in rat liver.","3335004","Phenobarbital","Receptor, Epidermal Growth Factor"]
["Phenobarbital","Receptor, Epidermal Growth Factor",0,0,0,0,"EGFR","10828207",2000,"EGF receptors of hepatocytes from rats treated with phenobarbital are sensitized to down-regulation by phenobarbital in culture.","10828207","Phenobarbital","Receptor, Epidermal Growth Factor"]
["Phenobarbital","Receptor, Epidermal Growth Factor",0,0,0,1,"EGFR","11439219",2001,"Phenobarbitone-induced liver response in wild type and in p53 deficient mice.","11439219","Phenobarbital","Receptor, Epidermal Growth Factor"]
["Phenobarbital","Receptor, Epidermal Growth Factor",0,0,0,0,"EGFR","9209685",1997,"Changes in protein and mRNA levels of growth factor/growth factor receptors in rat livers after administration of phenobarbitone or methylclofenapate.","9209685","Phenobarbital","Receptor, Epidermal Growth Factor"]
["Phenobarbital","Receptor, Epidermal Growth Factor",0,0,0,1,"EGFR","8640946",1996,"Expression of growth factors and growth factor receptors in the liver of C57BL/10J mice following administration of phenobarbitone.","8640946","Phenobarbital","Receptor, Epidermal Growth Factor"]
["Phenobarbital","Matrix Metalloproteinase 9",0,0,0,1,"MMP9","20661683",2011,"Matrix metalloproteinases 2 and 9 fail to influence drug-induced neuroapoptosis in developing rat brain.","20661683","Phenobarbital","Matrix Metalloproteinase 9"]
["Phenol","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","17085344",2006,"Feasibility and effectiveness of chemical bile duct embolization for chemical hepatectomy: a preliminary study.","17085344","Phenol","Transforming Growth Factor beta1"]
["Phenol","Tissue Inhibitor of Metalloproteinase-1",0,0,1,0,"TIMP1","17085344",2006,"Feasibility and effectiveness of chemical bile duct embolization for chemical hepatectomy: a preliminary study.","17085344","Phenol","Tissue Inhibitor of Metalloproteinase-1"]
["Phenytoin","Chemokine CCL2",0,0,1,0,"CCL2","14578793",2003,"Effect of sodium diphenylhydantoin on skin wound healing in rats.","14578793","Phenytoin","Chemokine CCL2"]
["Phenytoin","Collagen Type III",0,0,1,0,"COL3A1","15996772",2006,"Phenytoin can accelerate the healing process after experimental myocardial infarction?","15996772","Phenytoin","Collagen Type III"]
["Phenytoin","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","2139117",1990,"Effect of phenytoin medication on the metabolism of epidermal growth factor receptor in cultured gingival fibroblasts.","2139117","Phenytoin","Receptor, Epidermal Growth Factor"]
["Phenytoin","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","2366206",1990,"Regulation of epidermal growth factor receptor metabolism in gingival fibroblasts by phenytoin in vitro.","2366206","Phenytoin","Receptor, Epidermal Growth Factor"]
["Phenytoin","Receptor, Epidermal Growth Factor",0,0,1,1,"EGFR","9385775",1997,"Fibroblasts derived from tissue explants of dilantin-induced gingival hyperplasia and idiopathic gingival fibromatosis show distinct disparity in proliferative responsiveness to epidermal growth factor.","9385775","Phenytoin","Receptor, Epidermal Growth Factor"]
["Phenytoin","Matrix Metalloproteinase 1",0,0,1,0,"MMP1","18166100",2008,"Effects of cyclosporin, phenytoin, and nifedipine on the synthesis and degradation of gingival collagen in tufted capuchin monkeys (Cebus apella): histochemical and MMP-1 and -2 and collagen I gene expression analyses.","18166100","Phenytoin","Matrix Metalloproteinase 1"]
["Phenytoin","Matrix Metalloproteinase 1",0,0,1,0,"MMP1","16476037",2006,"Effect of phenytoin on collagen accumulation by human gingival fibroblasts exposed to TNF-alpha in vitro.","16476037","Phenytoin","Matrix Metalloproteinase 1"]
["Phenytoin","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","2176691",1990,"Effect of phenytoin and nifedipine on collagen gene expression in human gingival fibroblasts.","2176691","Phenytoin","Matrix Metalloproteinase 9"]
["Phenytoin","Transforming Growth Factor beta1",0,0,1,1,"TGFB1","15353252",2004,"Expression of growth factors in the gingival crevice fluid of patients with phenytoin-induced gingival enlargement.","15353252","Phenytoin","Transforming Growth Factor beta1"]
["Phenytoin","Tissue Inhibitor of Metalloproteinase-1",0,0,1,0,"TIMP1","16476037",2006,"Effect of phenytoin on collagen accumulation by human gingival fibroblasts exposed to TNF-alpha in vitro.","16476037","Phenytoin","Tissue Inhibitor of Metalloproteinase-1"]
["Phenytoin","Tissue Inhibitor of Metalloproteinase-1",0,0,1,0,"TIMP1","10914799",2000,"Phenytoin and cyclosporin A suppress the expression of MMP-1, TIMP-1, and cathepsin L, but not cathepsin B in cultured gingival fibroblasts.","10914799","Phenytoin","Tissue Inhibitor of Metalloproteinase-1"]
["Propylthiouracil","Matrix Metalloproteinase 9",1,1,1,0,"MMP9","19602776",2009,"Propylthiouracil attenuates monocrotaline-induced pulmonary arterial hypertension in rats.","19602776","Propylthiouracil","Matrix Metalloproteinase 9"]
["Pyrimethamine","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","23564480",2013,"Pyrimethamine sensitizes pituitary adenomas cells to temozolomide through cathepsin B-dependent and caspase-dependent apoptotic pathways.","23564480","Pyrimethamine","Matrix Metalloproteinase 9"]
["Quercetin","Chemokine CCL2",0,0,1,0,"CCL2","22402395",2012,"Effect of quercetin on inflammatory gene expression in mice liver in vivo - role of redox factor 1, miRNA-122 and miRNA-125b.","22402395","Quercetin","Chemokine CCL2"]
["Quercetin","Chemokine CCL2",0,0,1,0,"CCL2","16794257",2006,"Quercetin blocks airway epithelial cell chemokine expression.","16794257","Quercetin","Chemokine CCL2"]
["Quercetin","Chemokine CCL2",0,0,1,0,"CCL2","22775284",2013,"Flavonol-containing phosphorylated pullulan may attenuate pulp inflammation.","22775284","Quercetin","Chemokine CCL2"]
["Quercetin","Chemokine CCL2",0,0,1,0,"CCL2","22469745",2012,"Quercetin suppresses NF-?B and MCP-1 expression in a high glucose-induced             human mesangial cell proliferation model.","22469745","Quercetin","Chemokine CCL2"]
["Quercetin","Chemokine CCL2",0,0,1,0,"CCL2","23466460",2013,"Membranar effects exerted in vitro by polyphenols - quercetin, epigallocatechin gallate and curcumin - on HUVEC and Jurkat cells, relevant for diabetes mellitus.","23466460","Quercetin","Chemokine CCL2"]
["Quercetin","Chemokine CCL2",0,0,1,0,"CCL2","20361964",2010,"The effects of quercetin in cultured human RPE cells under oxidative stress and in Ccl2/Cx3cr1 double deficient mice.","20361964","Quercetin","Chemokine CCL2"]
["Quercetin","Chemokine CCL2",0,0,1,0,"CCL2","17191019",2006,"Inhibitory effect of quercetin on tryptase and MCP-1 chemokine release, and histidine decarboxylase mRNA transcription by human mast cell-1 cell line.","17191019","Quercetin","Chemokine CCL2"]
["Quercetin","Chemokine CCL2",0,0,1,0,"CCL2","17880982",2008,"Comparative effects of quercetin and its predominant human metabolites on adhesion molecule expression in activated human vascular endothelial cells.","17880982","Quercetin","Chemokine CCL2"]
["Quercetin","Chemokine CCL2",0,0,1,0,"CCL2","17717114",2007,"Quercetin's influence on exercise-induced changes in plasma cytokines and muscle and leukocyte cytokine mRNA.","17717114","Quercetin","Chemokine CCL2"]
["Quercetin","Chemokine CCL2",0,0,1,0,"CCL2","10541287",1999,"Bioflavonoid quercetin inhibits interleukin-1-induced transcriptional expression of monocyte chemoattractant protein-1 in glomerular cells via suppression of nuclear factor-kappaB.","10541287","Quercetin","Chemokine CCL2"]
["Quercetin","Chemokine CCL2",0,0,1,0,"CCL2","20542118",2010,"Quercetin attenuates Monocyte Chemoattractant Protein-1 gene expression in glucose primed aortic endothelial cells through NF-kappaB and AP-1.","20542118","Quercetin","Chemokine CCL2"]
["Quercetin","Chemokine CCL2",0,0,1,0,"CCL2","18489909",2009,"Physiologically relevant metabolites of quercetin have no effect on adhesion molecule or chemokine expression in human vascular smooth muscle cells.","18489909","Quercetin","Chemokine CCL2"]
["Quercetin","Chemokine CCL2",0,0,1,0,"CCL2","9292787",1997,"Quercetin, a bioflavonoid, inhibits the induction of interleukin 8 and monocyte chemoattractant protein-1 expression by tumor necrosis factor-alpha in cultured human synovial cells.","9292787","Quercetin","Chemokine CCL2"]
["Quercetin","Chemokine CCL2",0,0,1,0,"CCL2","9701255",1998,"Effect of bioflavonoids quercetin and curcumin on ischemic renal injury: a new class of renoprotective agents.","9701255","Quercetin","Chemokine CCL2"]
["Quercetin","Collagen Type III",0,0,1,0,"COL3A1","22915297",2012,"Quercetin treatment ameliorates inflammation and fibrosis in mice with nonalcoholic steatohepatitis.","22915297","Quercetin","Collagen Type III"]
["Quercetin","Collagen Type III",0,0,1,0,"COL3A1","16862918",2006,"[Inhibition of quercetin on liver fibrosis due to Schistosoma japonicum infection and on the expression of immediate early gene and metalloproteinase 1 inhibitor in liver tissue of mice].","16862918","Quercetin","Collagen Type III"]
["Quercetin","Collagen Type III",0,0,1,0,"COL3A1","17086741",2006,"Influence of quercetin and x-ray on collagen synthesis of cultured human keloid-derived fibroblasts.","17086741","Quercetin","Collagen Type III"]
["Quercetin","Chemokine CXCL10",0,0,1,0,"CXCL10","17449583",2007,"Quercetin inhibits TNF-induced NF-kappaB transcription factor recruitment to proinflammatory gene promoters in murine intestinal epithelial cells.","17449583","Quercetin","Chemokine CXCL10"]
["Quercetin","Chemokine CXCL10",0,0,1,0,"CXCL10","21779580",2011,"Antiproliferative mechanisms of quercetin in rat activated hepatic stellate cells.","21779580","Quercetin","Chemokine CXCL10"]
["Quercetin","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","22824072",2012,"The effect of quercetin on human neutrophil elastase-induced mucin5AC expression in human airway epithelial cells.","22824072","Quercetin","Receptor, Epidermal Growth Factor"]
["Quercetin","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","18618485",2008,"Comparison of delphinidin, quercetin and (-)-epigallocatechin-3-gallate as inhibitors of the EGFR and the ErbB2 receptor phosphorylation.","18618485","Quercetin","Receptor, Epidermal Growth Factor"]
["Quercetin","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","11759294",2001,"Differential responses of skin cancer-chemopreventive agents silibinin, quercetin, and epigallocatechin 3-gallate on mitogenic signaling and cell cycle regulators in human epidermoid carcinoma A431 cells.","11759294","Quercetin","Receptor, Epidermal Growth Factor"]
["Quercetin","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","14649542",2003,"Epidermal growth factor-responsive laryngeal squamous cancer cell line Hep2 is more sensitive than unresponsive CO-K3 one to quercetin and tamoxifen apoptotic effects.","14649542","Quercetin","Receptor, Epidermal Growth Factor"]
["Quercetin","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","12168845",2002,"Blockade of the epidermal growth factor receptor tyrosine kinase activity by quercetin and luteolin leads to growth inhibition and apoptosis of pancreatic tumor cells.","12168845","Quercetin","Receptor, Epidermal Growth Factor"]
["Quercetin","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","23618529",2013,"Quercetin induces growth arrest through activation of FOXO1 transcription factor in EGFR-overexpressing oral cancer cells.","23618529","Quercetin","Receptor, Epidermal Growth Factor"]
["Quercetin","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","10556937",1999,"Effects of luteolin and quercetin, inhibitors of tyrosine kinase, on cell growth and metastasis-associated properties in A431 cells overexpressing epidermal growth factor receptor.","10556937","Quercetin","Receptor, Epidermal Growth Factor"]
["Quercetin","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","10453447",1999,"Quercetin-induced apoptosis in colorectal tumor cells: possible role of EGF receptor signaling.","10453447","Quercetin","Receptor, Epidermal Growth Factor"]
["Quercetin","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","22805054",2012,"Taxifolin suppresses UV-induced skin carcinogenesis by targeting EGFR and PI3K.","22805054","Quercetin","Receptor, Epidermal Growth Factor"]
["Quercetin","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","21308698",2011,"Quercetin inhibits invasion, migration and signalling molecules involved in cell survival and proliferation of prostate cancer cell line (PC-3).","21308698","Quercetin","Receptor, Epidermal Growth Factor"]
["Quercetin","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","21562239",2011,"Suppression of amphiregulin/epidermal growth factor receptor signals contributes to the protective effects of quercetin in cirrhotic rats.","21562239","Quercetin","Receptor, Epidermal Growth Factor"]
["Quercetin","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","19251944",2009,"Quercetin stimulates Na+/K+/2Cl- cotransport via PTK-dependent mechanisms in human airway epithelium.","19251944","Quercetin","Receptor, Epidermal Growth Factor"]
["Quercetin","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","20082303",2010,"Quercetin suppresses HeLa cell viability via AMPK-induced HSP70 and EGFR down-regulation.","20082303","Quercetin","Receptor, Epidermal Growth Factor"]
["Quercetin","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","12741595",2003,"Selective separation of active inhibitors of epidermal growth factor receptor from Caragana jubata by molecularly imprinted solid-phase extraction.","12741595","Quercetin","Receptor, Epidermal Growth Factor"]
["Quercetin","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","8201603",1994,"Structural studies on bioactive compounds. 23. Synthesis of polyhydroxylated 2-phenylbenzothiazoles and a comparison of their cytotoxicities and pharmacological properties with genistein and quercetin.","8201603","Quercetin","Receptor, Epidermal Growth Factor"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L1540,L1540)","v":"Quercetin"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M1540,M1540)","v":"Receptors, LDL"},0,0,1,0,"LDLR",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K1540,K1540)","v":"22388943"},2012,"Quercetin up-regulates LDL receptor expression in HepG2 cells.","22388943","Quercetin","Receptors, LDL"]
["Quercetin","Receptors, LDL",0,0,1,0,"LDLR","20586760",2010,"Quercetin and ethanol attenuate the progression of atherosclerotic plaques with concomitant up regulation of paraoxonase1 (PON1) gene expression and PON1 activity in LDLR-/- mice.","20586760","Quercetin","Receptors, LDL"]
["Quercetin","Receptors, LDL",0,0,1,0,"LDLR","15795425",2005,"Mulberry (Morus alba L.) leaves and their major flavonol quercetin 3-(6-malonylglucoside) attenuate atherosclerotic lesion development in LDL receptor-deficient mice.","15795425","Quercetin","Receptors, LDL"]
["Quercetin","Matrix Metalloproteinase 1",0,0,1,0,"MMP1","18926575",2008,"Quercetin and interferon-beta modulate immune response(s) in peripheral blood mononuclear cells isolated from multiple sclerosis patients.","18926575","Quercetin","Matrix Metalloproteinase 1"]
["Quercetin","Matrix Metalloproteinase 1",0,0,1,0,"MMP1","21282043",2011,"Quercetin inhibits UV irradiation-induced inflammatory cytokine production in primary human keratinocytes by suppressing NF-?B pathway.","21282043","Quercetin","Matrix Metalloproteinase 1"]
["Quercetin","Matrix Metalloproteinase 1",0,0,1,0,"MMP1","22592909",2012,"Quercetin inhibits IL-1?-induced proliferation and production of MMPs, COX-2, and PGE2 by rheumatoid synovial fibroblast.","22592909","Quercetin","Matrix Metalloproteinase 1"]
["Quercetin","Matrix Metalloproteinase 1",0,0,1,0,"MMP1","16009522",2005,"The effect of flavonol glycoside on the expressions of matrix metalloproteinase-1 in ultraviolet-irradiated cultured human skin fibroblasts.","16009522","Quercetin","Matrix Metalloproteinase 1"]
["Quercetin","Matrix Metalloproteinase 1",0,0,1,0,"MMP1","20127038",2010,"Onion extract and quercetin induce matrix metalloproteinase-1 in vitro and in vivo.","20127038","Quercetin","Matrix Metalloproteinase 1"]
["Quercetin","Matrix Metalloproteinase 1",0,0,1,0,"MMP1","22997710",2012,"Study of skin anti-ageing and anti-inflammatory effects of dihydroquercetin, natural triterpenoids, and their synthetic derivatives.","22997710","Quercetin","Matrix Metalloproteinase 1"]
["Quercetin","Matrix Metalloproteinase 1",0,0,1,0,"MMP1","11414687",2001,"Quercetin inhibits matrix metalloproteinase-1 expression in human vascular endothelial cells through extracellular signal-regulated kinase.","11414687","Quercetin","Matrix Metalloproteinase 1"]
["Quercetin","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","18715546",2008,"Flavonoid glycosides isolated from Salicornia herbacea inhibit matrix metalloproteinase in HT1080 cells.","18715546","Quercetin","Matrix Metalloproteinase 9"]
["Quercetin","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","23902346",2013,"Quercetin suppresses intracellular ROS formation, MMP activation, and cell motility in human fibrosarcoma cells.","23902346","Quercetin","Matrix Metalloproteinase 9"]
["Quercetin","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","19061976",2009,"Quercetin regulates Th1/Th2 balance in a murine model of asthma.","19061976","Quercetin","Matrix Metalloproteinase 9"]
["Quercetin","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","19401153",2009,"Activation of phosphatidylinositol 3-kinase is required for tumor necrosis factor-alpha-induced upregulation of matrix metalloproteinase-9: its direct inhibition by quercetin.","19401153","Quercetin","Matrix Metalloproteinase 9"]
["Quercetin","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","18926575",2008,"Quercetin and interferon-beta modulate immune response(s) in peripheral blood mononuclear cells isolated from multiple sclerosis patients.","18926575","Quercetin","Matrix Metalloproteinase 9"]
["Quercetin","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","18628248",2008,"Quercetin inhibition of tumor invasion via suppressing PKC delta/ERK/AP-1-dependent matrix metalloproteinase-9 activation in breast carcinoma cells.","18628248","Quercetin","Matrix Metalloproteinase 9"]
["Quercetin","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","24337353",2014,"Quercetin reduces oxidative stress and inhibits activation of c?Jun N?terminal kinase/activator protein?1 signaling in an experimental mouse model of abdominal aortic aneurysm.","24337353","Quercetin","Matrix Metalloproteinase 9"]
["Quercetin","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","22728078",2012,"Quercetin, a flavonoid with anti-inflammatory activity, suppresses the development of abdominal aortic aneurysms in mice.","22728078","Quercetin","Matrix Metalloproteinase 9"]
["Quercetin","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","23645742",2013,"Quercetin inhibits migration and invasion of SAS human oral cancer cells through inhibition of NF-?B and matrix metalloproteinase-2/-9 signaling pathways.","23645742","Quercetin","Matrix Metalloproteinase 9"]
["Quercetin","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","23991004",2013,"Impact of flavonoids on matrix metalloproteinase secretion and invadopodia formation in highly invasive A431-III cancer cells.","23991004","Quercetin","Matrix Metalloproteinase 9"]
["Quercetin","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","21752154",2011,"Effects of dietary flavonoids, luteolin, and quercetin on the reversal of epithelial-mesenchymal transition in A431 epidermal cancer cells.","21752154","Quercetin","Matrix Metalloproteinase 9"]
["Quercetin","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","12589822",2003,"Quercetin exerts multiple inhibitory effects on vascular smooth muscle cells: role of ERK1/2, cell-cycle regulation, and matrix metalloproteinase-9.","12589822","Quercetin","Matrix Metalloproteinase 9"]
["Quercetin","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","22257724",2012,"The use of nano-quercetin to arrest mitochondrial damage and MMP-9 upregulation during prevention of gastric inflammation induced by ethanol in rat.","22257724","Quercetin","Matrix Metalloproteinase 9"]
["Quercetin","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","16645725",2006,"Quercetin downregulates matrix metalloproteinases 2 and 9 proteins expression in prostate cancer cells (PC-3).","16645725","Quercetin","Matrix Metalloproteinase 9"]
["Quercetin","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","22759961",2012,"Quercetin triggers apoptosis of lipopolysaccharide (LPS)-induced osteoclasts and inhibits bone resorption in RAW264.7 cells.","22759961","Quercetin","Matrix Metalloproteinase 9"]
["Quercetin","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","16806698",2006,"Protective effect of quercetin, a natural flavonoid against neuronal damage after transient global cerebral ischemia.","16806698","Quercetin","Matrix Metalloproteinase 9"]
["Quercetin","NF-E2-Related Factor 2",0,0,1,0,"NFE2L2","23770986",2013,"Quercetin protects rat dorsal root ganglion neurons against high glucose-induced injury in vitro through Nrf-2/HO-1 activation and NF-?B inhibition.","23770986","Quercetin","NF-E2-Related Factor 2"]
["Quercetin","NF-E2-Related Factor 2",0,0,1,0,"NFE2L2","17433488",2007,"Quercetin protects human hepatocytes from ethanol-derived oxidative stress by inducing heme oxygenase-1 via the MAPK/Nrf2 pathways.","17433488","Quercetin","NF-E2-Related Factor 2"]
["Quercetin","NF-E2-Related Factor 2",0,0,1,0,"NFE2L2","24076371",2013,"Quercetin inhibits lipopolysaccharide-induced nitric oxide production in BV2 microglial cells by suppressing the NF-?B pathway and activating the Nrf2-dependent HO-1 pathway.","24076371","Quercetin","NF-E2-Related Factor 2"]
["Quercetin","NF-E2-Related Factor 2",0,0,1,0,"NFE2L2","24211276",2014,"Isorhamnetin protects against oxidative stress by activating Nrf2 and inducing the expression of its target genes.","24211276","Quercetin","NF-E2-Related Factor 2"]
["Quercetin","NF-E2-Related Factor 2",0,0,1,0,"NFE2L2","19576171",2009,"Essential role of Nrf2 in keratinocyte protection from UVA by quercetin.","19576171","Quercetin","NF-E2-Related Factor 2"]
["Quercetin","NF-E2-Related Factor 2",0,0,1,0,"NFE2L2","19390785",2009,"Heme oxygenase-1 mediates the anti-allergic actions of quercetin in rodent mast cells.","19390785","Quercetin","NF-E2-Related Factor 2"]
["Quercetin","NF-E2-Related Factor 2",0,0,1,0,"NFE2L2","22197970",2012,"Quercetin modulates Nrf2 and glutathione-related defenses in HepG2 cells: Involvement of p38.","22197970","Quercetin","NF-E2-Related Factor 2"]
["Quercetin","NF-E2-Related Factor 2",0,0,1,0,"NFE2L2","17462537",2007,"Action of Nrf2 and Keap1 in ARE-mediated NQO1 expression by quercetin.","17462537","Quercetin","NF-E2-Related Factor 2"]
["Quercetin","NF-E2-Related Factor 2",0,0,1,0,"NFE2L2","21689633",2011,"Hyperoside attenuates hydrogen peroxide-induced L02 cell damage via MAPK-dependent Keap?-Nrf?-ARE signaling pathway.","21689633","Quercetin","NF-E2-Related Factor 2"]
["Quercetin","NF-E2-Related Factor 2",0,0,1,0,"NFE2L2","22996356",2013,"Quercetin reduces oxidative damage induced by paraquat via modulating expression of antioxidant genes in A549 cells.","22996356","Quercetin","NF-E2-Related Factor 2"]
["Quercetin","NF-E2-Related Factor 2",0,0,1,0,"NFE2L2","21624509",2011,"Hepatoprotection of quercetin against oxidative stress by induction of metallothionein expression through activating MAPK and PI3K pathways and enhancing Nrf2 DNA-binding activity.","21624509","Quercetin","NF-E2-Related Factor 2"]
["Quercetin","NF-E2-Related Factor 2",0,0,1,0,"NFE2L2","23419114",2013,"Dihydroquercetin (DHQ) induced HO-1 and NQO1 expression against oxidative stress through the Nrf2-dependent antioxidant pathway.","23419114","Quercetin","NF-E2-Related Factor 2"]
["Quercetin","NF-E2-Related Factor 2",0,0,1,0,"NFE2L2","24161694",2014,"Quercetin modulates OTA-induced oxidative stress and redox signalling in HepG2 cells - up regulation of Nrf2 expression and down regulation of NF-?B and COX-2.","24161694","Quercetin","NF-E2-Related Factor 2"]
["Quercetin","NF-E2-Related Factor 2",0,0,1,0,"NFE2L2","20554019",2010,"After cellular internalization, quercetin causes Nrf2 nuclear translocation, increases glutathione levels, and prevents neuronal death against an oxidative insult.","20554019","Quercetin","NF-E2-Related Factor 2"]
["Quercetin","NF-E2-Related Factor 2",0,0,1,0,"NFE2L2","19686811",2010,"Quercetin-3-O-beta-d-glucuronopyranoside (QGC)-induced HO-1 expression through ERK and PI3K activation in cultured feline esophageal epithelial cells.","19686811","Quercetin","NF-E2-Related Factor 2"]
["Quercetin","NF-E2-Related Factor 2",0,0,1,0,"NFE2L2","19956833",2010,"Inhibition of AP-1 and MAPK signaling and activation of Nrf2/ARE pathway by quercitrin.","19956833","Quercetin","NF-E2-Related Factor 2"]
["Quercetin","NF-E2-Related Factor 2",0,0,1,0,"NFE2L2","21428416",2011,"Protective effects of hyperoside against carbon tetrachloride-induced liver damage in mice.","21428416","Quercetin","NF-E2-Related Factor 2"]
["Quercetin","NF-E2-Related Factor 2",0,0,1,0,"NFE2L2","21051700",2011,"Quercetin induces the expression of peroxiredoxins 3 and 5 via the Nrf2/NRF1 transcription pathway.","21051700","Quercetin","NF-E2-Related Factor 2"]
["Quercetin","NF-E2-Related Factor 2",0,0,1,0,"NFE2L2","23294286",2013,"A novel semisynthetic flavonoid 7-O-galloyltaxifolin upregulates heme oxygenase-1 in RAW264.7 cells via MAPK/Nrf2 pathway.","23294286","Quercetin","NF-E2-Related Factor 2"]
["Quercetin","NF-E2-Related Factor 2",0,0,1,0,"NFE2L2","22056766",2012,"Heme oxygenase-1 mediates the protective role of quercetin against ethanol-induced rat hepatocytes oxidative damage.","22056766","Quercetin","NF-E2-Related Factor 2"]
["Quercetin","Receptors, Urokinase Plasminogen Activator",0,0,1,0,"PLAUR","21308698",2011,"Quercetin inhibits invasion, migration and signalling molecules involved in cell survival and proliferation of prostate cancer cell line (PC-3).","21308698","Quercetin","Receptors, Urokinase Plasminogen Activator"]
["Quercetin","E-Selectin",0,0,1,0,"SELE","18394220",2008,"A comparison of the effects of kaempferol and quercetin on cytokine-induced pro-inflammatory status of cultured human endothelial cells.","18394220","Quercetin","E-Selectin"]
["Quercetin","E-Selectin",0,0,1,0,"SELE","21601209",2011,"Anti-inflammatory, anti-proliferative and anti-atherosclerotic effects of quercetin in human in vitro and in vivo models.","21601209","Quercetin","E-Selectin"]
["Quercetin","E-Selectin",0,0,1,0,"SELE","19608276",2010,"Quercetin blocks caveolae-dependent pro-inflammatory responses induced by co-planar PCBs.","19608276","Quercetin","E-Selectin"]
["Quercetin","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","23220618",2013,"Antithrombotic and profibrinolytic activities of isorhamnetin-3-O-galactoside and hyperoside.","23220618","Quercetin","Plasminogen Activator Inhibitor 1"]
["Quercetin","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","20626032",2010,"Upstream stimulatory factor-2 mediates quercetin-induced suppression of PAI-1 gene expression in human endothelial cells.","20626032","Quercetin","Plasminogen Activator Inhibitor 1"]
["Quercetin","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","20510684",2010,"A further investigation concerning correlation between anti-fibrotic effect of liposomal quercetin and inflammatory cytokines in pulmonary fibrosis.","20510684","Quercetin","Transforming Growth Factor beta1"]
["Quercetin","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","22011322",2012,"Quercetin ameliorates diabetic nephropathy by reducing the expressions of transforming growth factor-?1 and connective tissue growth factor in streptozotocin-induced diabetic rats.","22011322","Quercetin","Transforming Growth Factor beta1"]
["Quercetin","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","21605637",2011,"In vitro suppression of quercetin on hypertrophy and extracellular matrix accumulation in rat glomerular mesangial cells cultured by high glucose.","21605637","Quercetin","Transforming Growth Factor beta1"]
["Quercetin","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","19243898",2009,"The effect of quercetin on neointima formation in a rat artery balloon injury model.","19243898","Quercetin","Transforming Growth Factor beta1"]
["Quercetin","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","17086741",2006,"Influence of quercetin and x-ray on collagen synthesis of cultured human keloid-derived fibroblasts.","17086741","Quercetin","Transforming Growth Factor beta1"]
["Quercetin","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","23596717",2013,"[Effect of quercetin on the expression of TGF-beta1 in human embryonic lung fibroblasts activated by the silicotic alveolar macrophages].","23596717","Quercetin","Transforming Growth Factor beta1"]
["Quercetin","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","12580099",2001,"[Antifibrotic effects of genistein and quercetin in vitro].","12580099","Quercetin","Transforming Growth Factor beta1"]
["Quercetin","Thrombomodulin",0,0,1,0,"THBD","17044640",2006,"Activity of Ginkgo biloba extract and quercetin on thrombomodulin expression and tissue-type plasminogen activator secretion by human umbilical vein endothelial cells.","17044640","Quercetin","Thrombomodulin"]
["Quercetin","Tissue Inhibitor of Metalloproteinase-1",0,0,1,0,"TIMP1","23829630",2013,"Gene expression profiling reveals underlying molecular mechanism of hepatoprotective effect of Phyllanthus niruri on thioacetamide-induced hepatotoxicity in Sprague Dawley rats.","23829630","Quercetin","Tissue Inhibitor of Metalloproteinase-1"]
["Quercetin","Tissue Inhibitor of Metalloproteinase-1",0,0,1,0,"TIMP1","18715546",2008,"Flavonoid glycosides isolated from Salicornia herbacea inhibit matrix metalloproteinase in HT1080 cells.","18715546","Quercetin","Tissue Inhibitor of Metalloproteinase-1"]
["Quercetin","Tissue Inhibitor of Metalloproteinase-1",0,0,1,0,"TIMP1","22592909",2012,"Quercetin inhibits IL-1?-induced proliferation and production of MMPs, COX-2, and PGE2 by rheumatoid synovial fibroblast.","22592909","Quercetin","Tissue Inhibitor of Metalloproteinase-1"]
["Quercetin","Tissue Inhibitor of Metalloproteinase-1",0,0,1,0,"TIMP1","16862918",2006,"[Inhibition of quercetin on liver fibrosis due to Schistosoma japonicum infection and on the expression of immediate early gene and metalloproteinase 1 inhibitor in liver tissue of mice].","16862918","Quercetin","Tissue Inhibitor of Metalloproteinase-1"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L1604,L1604)","v":"Quercetin"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M1604,M1604)","v":"Tissue Inhibitor of Metalloproteinase-1"},0,0,1,0,"TIMP1",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K1604,K1604)","v":"20127038"},2010,"Onion extract and quercetin induce matrix metalloproteinase-1 in vitro and in vivo.","20127038","Quercetin","Tissue Inhibitor of Metalloproteinase-1"]
["Quercetin","Tissue Inhibitor of Metalloproteinase-1",0,0,1,0,"TIMP1","11506819",2001,"Dietary supplementation with the anti-tumour promoter quercetin: its effects on matrix metalloproteinase gene regulation.","11506819","Quercetin","Tissue Inhibitor of Metalloproteinase-1"]
["Quercetin","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","15736313",2005,"Association between pterostilbene and quercetin inhibits metastatic activity of B16 melanoma.","15736313","Quercetin","Vascular Cell Adhesion Molecule-1"]
["Quercetin","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","15051824",2004,"Quercetin protects against linoleic acid-induced porcine endothelial cell dysfunction.","15051824","Quercetin","Vascular Cell Adhesion Molecule-1"]
["Quercetin","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","18489909",2009,"Physiologically relevant metabolites of quercetin have no effect on adhesion molecule or chemokine expression in human vascular smooth muscle cells.","18489909","Quercetin","Vascular Cell Adhesion Molecule-1"]
["Quercetin","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","19608276",2010,"Quercetin blocks caveolae-dependent pro-inflammatory responses induced by co-planar PCBs.","19608276","Quercetin","Vascular Cell Adhesion Molecule-1"]
["Quercetin","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","18394220",2008,"A comparison of the effects of kaempferol and quercetin on cytokine-induced pro-inflammatory status of cultured human endothelial cells.","18394220","Quercetin","Vascular Cell Adhesion Molecule-1"]
["Quercetin","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","21601209",2011,"Anti-inflammatory, anti-proliferative and anti-atherosclerotic effects of quercetin in human in vitro and in vivo models.","21601209","Quercetin","Vascular Cell Adhesion Molecule-1"]
["Quercetin","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","17880982",2008,"Comparative effects of quercetin and its predominant human metabolites on adhesion molecule expression in activated human vascular endothelial cells.","17880982","Quercetin","Vascular Cell Adhesion Molecule-1"]
["Raloxifene","Chemokine CCL2",0,0,1,0,"CCL2","22845341",2013,"Effect of raloxifene and atorvastatin in atherosclerotic process in ovariectomized rats.","22845341","Raloxifene","Chemokine CCL2"]
["Raloxifene","Chemokine CCL2",0,0,1,0,"CCL2","16842799",2007,"Circulating chemoattractants RANTES, negatively related to endogenous androgens, and MCP-1 are differentially suppressed by hormone therapy and raloxifene.","16842799","Raloxifene","Chemokine CCL2"]
["Raloxifene","Chemokine CCL2",0,0,1,0,"CCL2","17006379",2006,"Estrogen and raloxifene inhibit the monocytic chemoattractant protein-1-induced migration of human monocytic cells via nongenomic estrogen receptor alpha.","17006379","Raloxifene","Chemokine CCL2"]
["Raloxifene","Chemokine CCL2",0,0,1,0,"CCL2","18976766",2009,"Raloxifene reduces circulating levels of interleukin-7 and monocyte chemoattractant protein-1 in postmenopausal women.","18976766","Raloxifene","Chemokine CCL2"]
["Raloxifene","Chemokine CCL2",0,0,1,0,"CCL2","18367192",2008,"Selective estrogen receptor modulation influences atherosclerotic plaque composition in a rabbit menopause model.","18367192","Raloxifene","Chemokine CCL2"]
["Raloxifene","Antigens, CD40",0,0,1,0,"CD40","20551107",2010,"Raloxifene modulates estrogen-mediated B cell autoreactivity in NZB/W F1 mice.","20551107","Raloxifene","Antigens, CD40"]
["Raloxifene","Collagen Type III",0,0,1,0,"COL3A1","20073985",2010,"Effect of selective estrogen receptor modulator/raloxifene analogue on proliferation and collagen metabolism of tendon fibroblast.","20073985","Raloxifene","Collagen Type III"]
["Raloxifene","Collagen Type III",0,0,1,0,"COL3A1","21935668",2012,"The effect of raloxifene, a SERM, on extracellular matrix protein expression of pelvic fibroblasts.","21935668","Raloxifene","Collagen Type III"]
["Raloxifene","Collagen Type III",0,0,1,0,"COL3A1","22208761",2012,"The effects of conjugated estrogen, raloxifene and soy extract on collagen in rat bones.","22208761","Raloxifene","Collagen Type III"]
["Raloxifene","Macrophage Colony-Stimulating Factor",0,0,1,0,"CSF1","17420779",2007,"Differential effects of selective oestrogen receptor modulators (SERMs) tamoxifen, ospemifene and raloxifene on human osteoclasts in vitro.","17420779","Raloxifene","Macrophage Colony-Stimulating Factor"]
["Raloxifene","Macrophage Colony-Stimulating Factor",0,0,1,0,"CSF1","20613670",2010,"Effects of raloxifene on serum macrophage colony-stimulating factor and interleukin-18 levels in postmenopausal women younger than 60 years.","20613670","Raloxifene","Macrophage Colony-Stimulating Factor"]
["Raloxifene","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","23842642",2013,"Raloxifene reduces triple-negative breast cancer tumor growth and decreases EGFR expression.","23842642","Raloxifene","Receptor, Epidermal Growth Factor"]
["Raloxifene","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","18371987",2008,"The combination of raloxifene and epigallocatechin gallate suppresses growth and induces apoptosis in MDA-MB-231 cells.","18371987","Raloxifene","Receptor, Epidermal Growth Factor"]
["Raloxifene","Matrix Metalloproteinase 1",0,0,1,0,"MMP1","21964465",2012,"Activation of estrogen receptor ? by raloxifene through an activating protein-1-dependent tethering mechanism in human cervical epithelial cancer cells: a role for c-Jun N-terminal kinase.","21964465","Raloxifene","Matrix Metalloproteinase 1"]
["Raloxifene","Matrix Metalloproteinase 1",0,0,1,0,"MMP1","18367192",2008,"Selective estrogen receptor modulation influences atherosclerotic plaque composition in a rabbit menopause model.","18367192","Raloxifene","Matrix Metalloproteinase 1"]
["Raloxifene","Matrix Metalloproteinase 1",0,0,1,0,"MMP1","11498451",2001,"Raloxifene-mediated increase in matrix metalloproteinase-1 production by activated monocytes.","11498451","Raloxifene","Matrix Metalloproteinase 1"]
["Raloxifene","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","15814163",2005,"Interleukin-18 (IL-18) and matrix metalloproteinase-9 (MMP-9) in post-menopausal osteoporosis.","15814163","Raloxifene","Matrix Metalloproteinase 9"]
["Raloxifene","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","14533013",2003,"Differential effects of estradiol and raloxifene on collagen biosynthesis in cultured human skin fibroblasts.","14533013","Raloxifene","Matrix Metalloproteinase 9"]
["Raloxifene","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","17582780",2007,"Raloxifene inhibits matrix metalloproteinases expression and activity in macrophages and smooth muscle cells.","17582780","Raloxifene","Matrix Metalloproteinase 9"]
["Raloxifene","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","15167309",2004,"The effect of hormone therapy and raloxifene on serum matrix metalloproteinase-2 and -9 in postmenopausal women.","15167309","Raloxifene","Matrix Metalloproteinase 9"]
["Raloxifene","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","11447735",2001,"Estrogenic and antiestrogenic effects of raloxifene on collagen metabolism in breast cancer MCF-7 cells.","11447735","Raloxifene","Matrix Metalloproteinase 9"]
["Raloxifene","Receptors, Urokinase Plasminogen Activator",0,0,1,0,"PLAUR","16277677",2005,"Raloxifene reduces urokinase-type plasminogen activator-dependent proliferation of synoviocytes from patients with rheumatoid arthritis.","16277677","Raloxifene","Receptors, Urokinase Plasminogen Activator"]
["Raloxifene","E-Selectin",0,0,1,0,"SELE","12823645",2003,"Raloxifene, conjugated oestrogen and endothelial function in postmenopausal women.","12823645","Raloxifene","E-Selectin"]
["Raloxifene","E-Selectin",0,0,1,0,"SELE","20609538",2010,"XbaI polymorphism of the estrogen receptor alpha gene influences the effect of raloxifene on the endothelial function.","20609538","Raloxifene","E-Selectin"]
["Raloxifene","E-Selectin",0,0,1,0,"SELE","12727966",2003,"Endothelial function and menopause: effects of raloxifene administration.","12727966","Raloxifene","E-Selectin"]
["Raloxifene","E-Selectin",0,0,1,0,"SELE","18976766",2009,"Raloxifene reduces circulating levels of interleukin-7 and monocyte chemoattractant protein-1 in postmenopausal women.","18976766","Raloxifene","E-Selectin"]
["Raloxifene","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","24495689",2013,"[Effects of raloxifene combined with conjugated equine estrogen on prothrombotic state in ovariectomized rats].","24495689","Raloxifene","Plasminogen Activator Inhibitor 1"]
["Raloxifene","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","16277677",2005,"Raloxifene reduces urokinase-type plasminogen activator-dependent proliferation of synoviocytes from patients with rheumatoid arthritis.","16277677","Raloxifene","Plasminogen Activator Inhibitor 1"]
["Raloxifene","Plasminogen Activator Inhibitor 1",0,0,1,1,"SERPINE1","23323567",2013,"Dosing time-dependent effect of raloxifene on plasma plasminogen activator inhibitor-1 concentrations in post-menopausal women with osteoporosis.","23323567","Raloxifene","Plasminogen Activator Inhibitor 1"]
["Raloxifene","Plasminogen Activator Inhibitor 1",0,0,1,1,"SERPINE1","16167916",2005,"The effects of short-term raloxifene therapy on fibrinolysis markers: TAFI, tPA, and PAI-1.","16167916","Raloxifene","Plasminogen Activator Inhibitor 1"]
["Raloxifene","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","20590611",2010,"Genistein aglycone improves skin repair in an incisional model of wound healing: a comparison with raloxifene and oestradiol in ovariectomized rats.","20590611","Raloxifene","Transforming Growth Factor beta1"]
["Raloxifene","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","18066566",2008,"Effects of raloxifene and hormone replacement therapy on serum Th2 and Th3 type cytokine concentrations in healthy postmenopausal women: a randomised controlled trial.","18066566","Raloxifene","Transforming Growth Factor beta1"]
["Raloxifene","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","15762036",2004,"Effects of 17beta-estradiol, tamoxifen and raloxifene on the protein and mRNA expression of interleukin-6, transforming growth factor-beta1 and insulin-like growth factor-1 in primary human osteoblast cultures.","15762036","Raloxifene","Transforming Growth Factor beta1"]
["Raloxifene","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","17823083",2007,"Influence of the selective oestrogen receptor modulator (raloxifene hydrochloride) on IL-6, TNF-alpha, TGF-beta1 and bone turnover markers in the treatment of postmenopausal osteoporosis.","17823083","Raloxifene","Transforming Growth Factor beta1"]
["Raloxifene","Thrombomodulin",0,0,1,0,"THBD","11014248",2000,"17beta-estradiol, but not raloxifene, decreases thrombomodulin in the antithrombotic protein C pathway.","11014248","Raloxifene","Thrombomodulin"]
["Raloxifene","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","12727966",2003,"Endothelial function and menopause: effects of raloxifene administration.","12727966","Raloxifene","Vascular Cell Adhesion Molecule-1"]
["Rotenone","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","23762292",2013,"Deguelin action involves c-Met and EGFR signaling pathways in triple negative breast cancer cells.","23762292","Rotenone","Receptor, Epidermal Growth Factor"]
["Rotenone","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","20056314",2010,"Tephrosin induces internalization and degradation of EGFR and ErbB2 in HT-29 human colon cancer cells.","20056314","Rotenone","Receptor, Epidermal Growth Factor"]
["Rotenone","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","17158054",2007,"Rotenoids and flavonoids with anti-invasion of HT1080, anti-proliferation of U937, and differentiation-inducing activity in HL-60 from Erycibe expansa.","17158054","Rotenone","Matrix Metalloproteinase 9"]
["Rotenone","NF-E2-Related Factor 2",0,0,1,0,"NFE2L2","18325346",2008,"Role and regulation of ferritin H in rotenone-mediated mitochondrial oxidative stress.","18325346","Rotenone","NF-E2-Related Factor 2"]
["Rotenone","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","22986522",2013,"Deguelin suppresses pancreatic tumor growth and metastasis by inhibiting epithelial-to-mesenchymal transition in an orthotopic model.","22986522","Rotenone","Transforming Growth Factor beta1"]
["Sodium Fluoride","Macrophage Colony-Stimulating Factor",1,0,0,1,"CSF1","21176538",2010,"[The influence of fluoride on expression of OPGL and M-CSF genes and their proteins in rats with experimental fluorosis and the therapeutic effect of Danlan Xianpeng Liaofu caspule].","21176538","Sodium Fluoride","Macrophage Colony-Stimulating Factor"]
["Sodium Fluoride","Receptor, Epidermal Growth Factor",1,0,0,1,"EGFR","19376214",2009,"Fluoride-induced cyclooxygenase-2 expression and prostaglandin E2 production in A549 human pulmonary epithelial cells.","19376214","Sodium Fluoride","Receptor, Epidermal Growth Factor"]
["Sodium Fluoride","Matrix Metalloproteinase 9",1,0,0,0,"MMP9","24196489",2014,"Sodium fluoride inhibits MMP-2 and MMP-9.","24196489","Sodium Fluoride","Matrix Metalloproteinase 9"]
["Sodium Fluoride","Matrix Metalloproteinase 9",1,0,0,0,"MMP9","23338253",2012,"Fluoride modulates preosteoblasts viability and matrix metalloproteinases-2 and -9 activities.","23338253","Sodium Fluoride","Matrix Metalloproteinase 9"]
["Sodium Fluoride","Serum Amyloid A Protein",1,0,0,1,"SAA1","9518651",1998,"Chronic administration of aluminum-fluoride or sodium-fluoride to rats in drinking water: alterations in neuronal and cerebrovascular integrity.","9518651","Sodium Fluoride","Serum Amyloid A Protein"]
["Sodium Fluoride","Transforming Growth Factor beta1",1,0,0,0,"TGFB1","14713283",2004,"Influence of fluor salts, hormone replacement therapy and calcitonin on the concentration of insulin-like growth factor (IGF)-I, IGF-II and transforming growth factor-beta 1 in human iliac crest bone matrix from patients with primary osteoporosis.","14713283","Sodium Fluoride","Transforming Growth Factor beta1"]
["Sodium Nitrite","Chemokine CCL2",1,0,1,0,"CCL2","23862714",2013,"Hepatoprotective effects of cod liver oil against sodium nitrite toxicity in rats.","23862714","Sodium Nitrite","Chemokine CCL2"]
["Sodium Nitrite","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","21800536",2011,"[Sodium nitrite induces epithelial-mesenchymal transition of SMMC-7721 cells].","21800536","Sodium Nitrite","Transforming Growth Factor beta1"]
["Spironolactone","Chemokine CCL2",0,0,1,0,"CCL2","16837769",2006,"Anti-inflammatory effect of spironolactone on human peripheral blood mononuclear cells.","16837769","Spironolactone","Chemokine CCL2"]
["Spironolactone","Chemokine CCL2",0,0,1,0,"CCL2","19620512",2009,"Role of mineralocorticoid receptor on experimental cerebral aneurysms in rats.","19620512","Spironolactone","Chemokine CCL2"]
["Spironolactone","Chemokine CCL2",0,0,1,0,"CCL2","16571782",2006,"Spironolactone prevents diabetic nephropathy through an anti-inflammatory mechanism in type 2 diabetic rats.","16571782","Spironolactone","Chemokine CCL2"]
["Spironolactone","Chemokine CCL2",0,0,1,0,"CCL2","22184057",2012,"Role of mineralocorticoid receptor/Rho/Rho-kinase pathway in obesity-related renal injury.","22184057","Spironolactone","Chemokine CCL2"]
["Spironolactone","Chemokine CCL2",0,0,1,0,"CCL2","16424347",2006,"Eplerenone with valsartan effectively reduces atherosclerotic lesion by attenuation of oxidative stress and inflammation.","16424347","Spironolactone","Chemokine CCL2"]
["Spironolactone","Chemokine CCL2",0,0,1,0,"CCL2","12384457",2002,"Aldosterone induces a vascular inflammatory phenotype in the rat heart.","12384457","Spironolactone","Chemokine CCL2"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L1668,L1668)","v":"Spironolactone"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M1668,M1668)","v":"Chemokine CCL2"},0,0,1,0,"CCL2",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K1668,K1668)","v":"16203870"},2005,"Eplerenone inhibits atherosclerosis in nonhuman primates.","16203870","Spironolactone","Chemokine CCL2"]
["Spironolactone","Chemokine CCL2",0,0,1,0,"CCL2","16569732",2006,"Aldosterone blockade attenuates urinary monocyte chemoattractant protein-1 and oxidative stress in patients with type 2 diabetes complicated by diabetic nephropathy.","16569732","Spironolactone","Chemokine CCL2"]
["Spironolactone","Chemokine CCL2",0,0,1,0,"CCL2","23731681",2013,"Protective effects of selective mineralocorticoid receptor antagonist against aortic aneurysm progression in a novel murine model.","23731681","Spironolactone","Chemokine CCL2"]
["Spironolactone","Chemokine CCL2",0,0,1,0,"CCL2","16555582",2005,"Cardioprotective mechanisms of spironolactone associated with the angiotensin-converting enzyme/epidermal growth factor receptor/extracellular signal-regulated kinases, NAD(P)H oxidase/lectin-like oxidized low-density lipoprotein receptor-1, and Rho-kinase pathways in aldosterone/salt-induced hypertensive rats.","16555582","Spironolactone","Chemokine CCL2"]
["Spironolactone","Chemokine CCL2",0,0,1,0,"CCL2","22641568",2013,"Aldosterone mediates glomerular inflammation in experimental mesangial proliferative glomerulonephritis.","22641568","Spironolactone","Chemokine CCL2"]
["Spironolactone","Chemokine CCL2",0,0,1,0,"CCL2","24260540",2013,"Spironolactone attenuates bleomycin-induced pulmonary injury partially via modulating mononuclear phagocyte phenotype switching in circulating and alveolar compartments.","24260540","Spironolactone","Chemokine CCL2"]
["Spironolactone","Antigens, CD40",0,0,1,0,"CD40","19655157",2010,"Oral contraceptives alone and with spironolactone increase sCD40 ligand in PCOS patients.","19655157","Spironolactone","Antigens, CD40"]
["Spironolactone","Collagen Type III",0,0,1,0,"COL3A1","21378011",2011,"Effects of spironolactone on cardiac sympathetic nerve activity and left ventricular remodelling after reperfusion therapy in patients with first ST-segment elevation myocardial infarction.","21378011","Spironolactone","Collagen Type III"]
["Spironolactone","Collagen Type III",0,0,1,0,"COL3A1","12451013",2002,"Increased carotid wall elastic modulus and fibronectin in aldosterone-salt-treated rats: effects of eplerenone.","12451013","Spironolactone","Collagen Type III"]
["Spironolactone","Collagen Type III",0,0,1,0,"COL3A1","15097243",2004,"Aldosterone antagonist facilitates the cardioprotective effects of angiotensin receptor blockers in hypertensive rats.","15097243","Spironolactone","Collagen Type III"]
["Spironolactone","Collagen Type III",0,0,1,0,"COL3A1","23505112",2013,"[Effects of spironolactone on type I, III collagen concentration in myocardium of spontaneous hypertension rats].","23505112","Spironolactone","Collagen Type III"]
["Spironolactone","Collagen Type III",0,0,1,0,"COL3A1","15467302",2005,"Effects of eplerenone, a selective aldosterone blocker, on the progression of left ventricular dysfunction and remodeling in rats with dilated cardiomyopathy.","15467302","Spironolactone","Collagen Type III"]
["Spironolactone","Collagen Type III",0,0,1,0,"COL3A1","19850207",2009,"Natural history of markers of collagen turnover in patients with early diastolic dysfunction and impact of eplerenone.","19850207","Spironolactone","Collagen Type III"]
["Spironolactone","Collagen Type III",0,0,1,0,"COL3A1","15056838",2004,"Effects of aldosterone receptor antagonist and angiotensin II type I receptor blocker on cardiac transcriptional factors and mRNA expression in rats with myocardial infarction.","15056838","Spironolactone","Collagen Type III"]
["Spironolactone","Collagen Type III",0,0,1,0,"COL3A1","16023229",2006,"Eplerenone suppresses neointimal formation after coronary stent implantation in swine.","16023229","Spironolactone","Collagen Type III"]
["Spironolactone","Collagen Type III",0,0,1,0,"COL3A1","17452731",2007,"Aldosterone antagonism fails to attenuate age-associated left ventricular fibrosis.","17452731","Spironolactone","Collagen Type III"]
["Spironolactone","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","16555582",2005,"Cardioprotective mechanisms of spironolactone associated with the angiotensin-converting enzyme/epidermal growth factor receptor/extracellular signal-regulated kinases, NAD(P)H oxidase/lectin-like oxidized low-density lipoprotein receptor-1, and Rho-kinase pathways in aldosterone/salt-induced hypertensive rats.","16555582","Spironolactone","Receptor, Epidermal Growth Factor"]
["Spironolactone","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","11507012",2001,"Spironolactone reduces cerebral infarct size and EGF-receptor mRNA in stroke-prone rats.","11507012","Spironolactone","Receptor, Epidermal Growth Factor"]
["Spironolactone","Receptors, LDL",0,0,1,0,"LDLR","15710785",2005,"Eplerenone shows renoprotective effect by reducing LOX-1-mediated adhesion molecule, PKCepsilon-MAPK-p90RSK, and Rho-kinase pathway.","15710785","Spironolactone","Receptors, LDL"]
["Spironolactone","Matrix Metalloproteinase 1",0,0,1,0,"MMP1","11094035",2000,"Limitation of excessive extracellular matrix turnover may contribute to survival benefit of spironolactone therapy in patients with congestive heart failure: insights from the randomized aldactone evaluation study (RALES). Rales Investigators.","11094035","Spironolactone","Matrix Metalloproteinase 1"]
["Spironolactone","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","19464421",2009,"Left ventricular remodeling after acute myocardial infarction: does eplerenone have an effect?","19464421","Spironolactone","Matrix Metalloproteinase 9"]
["Spironolactone","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","22742718",2012,"Usefulness of matrix metalloproteinase-9 plasma levels to identify patients with preserved left ventricular systolic function after acute myocardial infarction who could benefit from eplerenone.","22742718","Spironolactone","Matrix Metalloproteinase 9"]
["Spironolactone","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","24098808",2013,"Mechanisms involved in the beneficial effects of spironolactone after myocardial infarction.","24098808","Spironolactone","Matrix Metalloproteinase 9"]
["Spironolactone","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","10972684",2000,"Aldosterone modulates plasminogen activator inhibitor-1 and glomerulosclerosis in vivo.","10972684","Spironolactone","Plasminogen Activator Inhibitor 1"]
["Spironolactone","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","17142138",2006,"The effect of spironolactone on circulating adipocytokines in patients with type 2 diabetes mellitus complicated by diabetic nephropathy.","17142138","Spironolactone","Plasminogen Activator Inhibitor 1"]
["Spironolactone","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","15458443",2004,"Spironolactone prevents early renal injury in streptozotocin-induced diabetic rats.","15458443","Spironolactone","Plasminogen Activator Inhibitor 1"]
["Spironolactone","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","18372278",2008,"A dynamic comparative study concerning the effects of angiotensin-converting enzyme inhibitors and aldosterone receptor blockers on the fibrinolytic system.","18372278","Spironolactone","Plasminogen Activator Inhibitor 1"]
["Spironolactone","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","20470281",2010,"Effect of combined angiotensin-converting enzyme and aldosterone inhibition on plasma plasminogen activator inhibitor type 1 levels in chronic hypertensive patients.","20470281","Spironolactone","Plasminogen Activator Inhibitor 1"]
["Spironolactone","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","18682491",2009,"Effect of eplerenone, enalapril and their combination treatment on diabetic nephropathy in type II diabetic rats.","18682491","Spironolactone","Plasminogen Activator Inhibitor 1"]
["Spironolactone","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","17907099",2007,"Beneficial effects of spironolactone on glomerular injury in streptozotocin-induced diabetic rats.","17907099","Spironolactone","Plasminogen Activator Inhibitor 1"]
["Spironolactone","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","12424430",2002,"Effect of spironolactone on impaired fibrinolysis of hypertensive patients.","12424430","Spironolactone","Plasminogen Activator Inhibitor 1"]
["Spironolactone","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","18360019",2008,"Effect of renin-angiotensin-aldosterone system triple blockade on non-diabetic renal disease: addition of an aldosterone blocker, spironolactone, to combination treatment with an angiotensin-converting enzyme inhibitor and angiotensin II receptor blocker.","18360019","Spironolactone","Plasminogen Activator Inhibitor 1"]
["Spironolactone","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","11584810",2001,"Aldosterone 2001.","11584810","Spironolactone","Plasminogen Activator Inhibitor 1"]
["Spironolactone","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","11836266",2002,"Spironolactone abolishes the relationship between aldosterone and plasminogen activator inhibitor-1 in humans.","11836266","Spironolactone","Plasminogen Activator Inhibitor 1"]
["Spironolactone","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","12693733",2003,"Aldosterone as a target in congestive heart failure.","12693733","Spironolactone","Plasminogen Activator Inhibitor 1"]
["Spironolactone","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","23748277",2013,"Alport syndrome: the effects of spironolactone on proteinuria and urinary TGF-?1.","23748277","Spironolactone","Transforming Growth Factor beta1"]
["Spironolactone","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","18603054",2008,"Spironolactone alleviates late cardiac remodeling after left ventricular restoration surgery.","18603054","Spironolactone","Transforming Growth Factor beta1"]
["Spironolactone","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","24862968",2014,"The aldosterone receptor antagonist spironolactone prevents peritoneal inflammation and fibrosis.","24862968","Spironolactone","Transforming Growth Factor beta1"]
["Spironolactone","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","18250361",2008,"Spironolactone suppresses peritubular capillary loss and prevents deoxycorticosterone acetate/salt-induced tubulointerstitial fibrosis.","18250361","Spironolactone","Transforming Growth Factor beta1"]
["Spironolactone","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","15458443",2004,"Spironolactone prevents early renal injury in streptozotocin-induced diabetic rats.","15458443","Spironolactone","Transforming Growth Factor beta1"]
["Spironolactone","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","21908416",2012,"Long-term mineralocorticoid receptor blockade ameliorates progression of experimental diabetic renal disease.","21908416","Spironolactone","Transforming Growth Factor beta1"]
["Spironolactone","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","18434388",2008,"Regression of glomerulosclerosis in subtotally nephrectomized rats: effects of monotherapy with losartan, spironolactone, and their combination.","18434388","Spironolactone","Transforming Growth Factor beta1"]
["Spironolactone","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","17907099",2007,"Beneficial effects of spironolactone on glomerular injury in streptozotocin-induced diabetic rats.","17907099","Spironolactone","Transforming Growth Factor beta1"]
["Spironolactone","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","17998773",2007,"Combination therapy with telmisartan and spironolactone alleviates L-NAME exacerbated nephrosclerosis with an increase in PPAR-gamma and decrease in TGF-beta(1).","17998773","Spironolactone","Transforming Growth Factor beta1"]
["Spironolactone","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","22989552",2013,"Two drugs with paradoxical effects on liver regeneration through antiangiogenesis and antifibrosis: Losartan and Spironolactone: a pharmacologic dilemma on hepatocyte proliferation.","22989552","Spironolactone","Transforming Growth Factor beta1"]
["Spironolactone","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","17602151",2007,"The effects of irbesartan and spironolactone in prevention of peritoneal fibrosis in rats.","17602151","Spironolactone","Transforming Growth Factor beta1"]
["Spironolactone","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","24260540",2013,"Spironolactone attenuates bleomycin-induced pulmonary injury partially via modulating mononuclear phagocyte phenotype switching in circulating and alveolar compartments.","24260540","Spironolactone","Transforming Growth Factor beta1"]
["Spironolactone","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","12472767",2003,"Therapeutic benefit of spironolactone in experimental chronic cyclosporine A nephrotoxicity.","12472767","Spironolactone","Transforming Growth Factor beta1"]
["Spironolactone","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","19925284",2009,"Antifibrotic effects of aldosterone receptor blocker (spironolactone) in patients with chronic kidney disease.","19925284","Spironolactone","Transforming Growth Factor beta1"]
["Spironolactone","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","18682491",2009,"Effect of eplerenone, enalapril and their combination treatment on diabetic nephropathy in type II diabetic rats.","18682491","Spironolactone","Transforming Growth Factor beta1"]
["Spironolactone","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","16555582",2005,"Cardioprotective mechanisms of spironolactone associated with the angiotensin-converting enzyme/epidermal growth factor receptor/extracellular signal-regulated kinases, NAD(P)H oxidase/lectin-like oxidized low-density lipoprotein receptor-1, and Rho-kinase pathways in aldosterone/salt-induced hypertensive rats.","16555582","Spironolactone","Transforming Growth Factor beta1"]
["Spironolactone","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","18360019",2008,"Effect of renin-angiotensin-aldosterone system triple blockade on non-diabetic renal disease: addition of an aldosterone blocker, spironolactone, to combination treatment with an angiotensin-converting enzyme inhibitor and angiotensin II receptor blocker.","18360019","Spironolactone","Transforming Growth Factor beta1"]
["Spironolactone","Tissue Inhibitor of Metalloproteinase-1",0,0,1,0,"TIMP1","11094035",2000,"Limitation of excessive extracellular matrix turnover may contribute to survival benefit of spironolactone therapy in patients with congestive heart failure: insights from the randomized aldactone evaluation study (RALES). Rales Investigators.","11094035","Spironolactone","Tissue Inhibitor of Metalloproteinase-1"]
["Spironolactone","Tissue Inhibitor of Metalloproteinase-1",0,0,1,0,"TIMP1","15687129",2005,"Mineralocorticoid receptor inhibition ameliorates the transition to myocardial failure and decreases oxidative stress and inflammation in mice with chronic pressure overload.","15687129","Spironolactone","Tissue Inhibitor of Metalloproteinase-1"]
["Spironolactone","Tissue Inhibitor of Metalloproteinase-1",0,0,1,0,"TIMP1","24098808",2013,"Mechanisms involved in the beneficial effects of spironolactone after myocardial infarction.","24098808","Spironolactone","Tissue Inhibitor of Metalloproteinase-1"]
["Spironolactone","Tissue Inhibitor of Metalloproteinase-1",0,0,1,0,"TIMP1","17940859",2007,"Effect of long-term monotherapy with the aldosterone receptor blocker eplerenone on cytoskeletal proteins and matrix metalloproteinases in dogs with heart failure.","17940859","Spironolactone","Tissue Inhibitor of Metalloproteinase-1"]
["Spironolactone","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","12384457",2002,"Aldosterone induces a vascular inflammatory phenotype in the rat heart.","12384457","Spironolactone","Vascular Cell Adhesion Molecule-1"]
["Sulfasalazine","Chemokine CCL2",1,0,1,0,"CCL2","12231210",2002,"The effect of sulfasalazine on rheumatoid arthritic synovial tissue chemokine production.","12231210","Sulfasalazine","Chemokine CCL2"]
["Sulfasalazine","Chemokine CCL2",1,0,1,0,"CCL2","10513809",1999,"Treatment with sulfasalazine or sulfapyridine, but not 5-aminosalicyclic acid, inhibits basic fibroblast growth factor-induced endothelial cell chemotaxis.","10513809","Sulfasalazine","Chemokine CCL2"]
["Sulfasalazine","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","22119283",2012,"Suppression of TNBS-induced colitis in rats by 4-methylesculetin, a natural coumarin: comparison with prednisolone and sulphasalazine.","22119283","Sulfasalazine","Matrix Metalloproteinase 9"]
["Sulfasalazine","NF-E2-Related Factor 2",1,0,1,0,"NFE2L2","19234301",2009,"Sulfasalazine induces haem oxygenase-1 via ROS-dependent Nrf2 signalling, leading to control of neointimal hyperplasia.","19234301","Sulfasalazine","NF-E2-Related Factor 2"]
["Sulfasalazine","Serum Amyloid A Protein",1,0,1,0,"SAA1","2859902",1985,"Serum amyloid A protein during the treatment of rheumatoid arthritis with second-line drugs.","2859902","Sulfasalazine","Serum Amyloid A Protein"]
["Sulfasalazine","Serum Amyloid A Protein",1,0,1,0,"SAA1","9805922",1998,"[Beneficial effect of salazosulfapyridine (SASP) in a patient with secondary renal amyloidosis].","9805922","Sulfasalazine","Serum Amyloid A Protein"]
["Sulfasalazine","E-Selectin",1,0,1,0,"SELE","11264155",2001,"Modulation of endothelial cell activation in sickle cell disease: a pilot study.","11264155","Sulfasalazine","E-Selectin"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L1732,L1732)","v":"Sulfasalazine"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M1732,M1732)","v":"E-Selectin"},1,0,1,0,"SELE",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K1732,K1732)","v":"10598732"},1999,"Sulfasalazine inhibits reperfusion injury and prolongs allograft survival in rat cardiac transplants.","10598732","Sulfasalazine","E-Selectin"]
["Sulfasalazine","E-Selectin",1,0,1,0,"SELE","9751471",1998,"Soluble cell adhesion molecules--P-selectin and ICAM-1, and disease activity in patients receiving sulphasalazine for active rheumatoid arthritis.","9751471","Sulfasalazine","E-Selectin"]
["Sulfasalazine","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","10598732",1999,"Sulfasalazine inhibits reperfusion injury and prolongs allograft survival in rat cardiac transplants.","10598732","Sulfasalazine","Vascular Cell Adhesion Molecule-1"]
["Sulfasalazine","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","11264155",2001,"Modulation of endothelial cell activation in sickle cell disease: a pilot study.","11264155","Sulfasalazine","Vascular Cell Adhesion Molecule-1"]
["Sulfasalazine","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","22029500",2011,"Resveratrol abrogates adhesion molecules and protects against TNBS-induced ulcerative colitis in rats.","22029500","Sulfasalazine","Vascular Cell Adhesion Molecule-1"]
["Sulfasalazine","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","9751471",1998,"Soluble cell adhesion molecules--P-selectin and ICAM-1, and disease activity in patients receiving sulphasalazine for active rheumatoid arthritis.","9751471","Sulfasalazine","Vascular Cell Adhesion Molecule-1"]
["suplatast tosilate","Chemokine CCL2",0,0,0,0,"CCL2","18832650",2009,"Suplatast tosilate prevents bleomycin-induced pulmonary fibrosis in mice.","18832650","suplatast tosilate","Chemokine CCL2"]
["suplatast tosilate","Antigens, CD40",0,0,0,0,"CD40","11817674",2001,"Suppressive effects of anti-allergic agent suplatast tosilate (IPD-1151T) on the expression of co-stimulatory molecules on mouse splenocytes in vivo.","11817674","suplatast tosilate","Antigens, CD40"]
["suplatast tosilate","Vascular Cell Adhesion Molecule-1",0,0,0,0,"VCAM1","11710545",2001,"Modification of eosinophil function by suplatast tosilate (IPD), a novel anti-allergic drug.","11710545","suplatast tosilate","Vascular Cell Adhesion Molecule-1"]
["Tamoxifen","Chemokine CCL2",0,0,1,0,"CCL2","16866022",2006,"Expression of monocyte chemotactic protein-1 in human endometrial cancer cells and the effect of treatment with tamoxifen or buserelin.","16866022","Tamoxifen","Chemokine CCL2"]
["Tamoxifen","Chemokine CCL2",0,0,1,0,"CCL2","23038002",2012,"Hepatoprotective effect of tamoxifen on steatosis and non-alcoholic steatohepatitis in mouse models.","23038002","Tamoxifen","Chemokine CCL2"]
["Tamoxifen","Collagen Type III",0,0,1,0,"COL3A1","20825049",2010,"[Collagen type III biosynthesis by cultured pubocervical fascia fibroblasts surrounding mono and multifilament polypropylene mesh after estrogens and tamoxifen treatment].","20825049","Tamoxifen","Collagen Type III"]
["Tamoxifen","Macrophage Colony-Stimulating Factor",0,0,1,0,"CSF1","17420779",2007,"Differential effects of selective oestrogen receptor modulators (SERMs) tamoxifen, ospemifene and raloxifene on human osteoclasts in vitro.","17420779","Tamoxifen","Macrophage Colony-Stimulating Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","15173068",2004,"Human epidermal growth factor receptor 2 status modulates subcellular localization of and interaction with estrogen receptor alpha in breast cancer cells.","15173068","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","21273576",2011,"Measuring IGF-1, ER-? and EGFR expression can predict tamoxifen-resistance in ER-positive breast cancer.","21273576","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","22833200",2012,"Feature extraction via composite scoring and voting in breast cancer.","22833200","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","14649542",2003,"Epidermal growth factor-responsive laryngeal squamous cancer cell line Hep2 is more sensitive than unresponsive CO-K3 one to quercetin and tamoxifen apoptotic effects.","14649542","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","12538508",2003,"ErbB (HER) receptors can abrogate antiestrogen action in human breast cancer by multiple signaling mechanisms.","12538508","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","12894229",2003,"Oestrogens and selective oestrogen receptor (ER) modulators regulate EGF receptor gene expression through human ER alpha and beta subtypes via an Sp1 site.","12894229","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","20669046",2011,"Combined Src and ER blockade impairs human breast cancer proliferation in vitro and in vivo.","20669046","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","22808167",2012,"Tamoxifen-induced epigenetic silencing of oestrogen-regulated genes in anti-hormone resistant breast cancer.","22808167","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","19911269",2010,"Role of GPR30 in the mechanisms of tamoxifen resistance in breast cancer MCF-7 cells.","19911269","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","12960029",2003,"The antiepidermal growth factor receptor agent gefitinib (ZD1839/Iressa) improves antihormone response and prevents development of resistance in breast cancer in vitro.","12960029","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,1,"EGFR","21220480",2011,"Gefitinib or placebo in combination with tamoxifen in patients with hormone receptor-positive metastatic breast cancer: a randomized phase II study.","21220480","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","15355892",2004,"HER-2 amplification, HER-1 expression, and tamoxifen response in estrogen receptor-positive metastatic breast cancer: a southwest oncology group study.","15355892","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","12820409",2003,"mRNA expression of the type I growth factor receptors in the human breast cancer cells MCF-7: regulation by estradiol and tamoxifen.","12820409","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","1444236",1992,"The response of breast cancer cells to steroid and peptide growth factors.","1444236","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","23039365",2012,"Overexpression of CD44 accompanies acquired tamoxifen resistance in MCF7 cells and augments their sensitivity to the stromal factors, heregulin and hyaluronan.","23039365","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","21690342",2012,"The HOXB7 protein renders breast cancer cells resistant to tamoxifen through activation of the EGFR pathway.","21690342","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","20386540",2010,"EGFR/HER2 inhibitor AEE788 increases ER-mediated transcription in HER2/ER-positive breast cancer cells but functions synergistically with endocrine therapy.","20386540","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","14559846",2003,"Letrozole inhibits tumor proliferation more effectively than tamoxifen independent of HER1/2 expression status.","14559846","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","12586780",2003,"Elevated levels of epidermal growth factor receptor/c-erbB2 heterodimers mediate an autocrine growth regulatory pathway in tamoxifen-resistant MCF-7 cells.","12586780","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","12756077",2003,"Human epidermal growth factor receptor-2 and hormonal therapies: clinical implications.","12756077","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","2268352",1990,"Mechanisms of 4-hydroxytamoxifen anti-growth factor activity in breast cancer cells: alterations of growth factor receptor binding sites and tyrosine kinase activity.","2268352","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","14603258",2003,"Herstatin inhibits heregulin-mediated breast cancer cell growth and overcomes tamoxifen resistance in breast cancer cells that overexpress HER-2.","14603258","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","12631604",2003,"Twenty-year results of the Naples GUN randomized trial: predictive factors of adjuvant tamoxifen efficacy in early breast cancer.","12631604","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","23729263",2013,"Studying protein-ligand interactions using X-ray crystallography.","23729263","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","1498070",1992,"Towards a molecular basis for tamoxifen resistance in breast cancer.","1498070","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","22854050",2012,"Activated HER-receptors in predicting outcome of ER-positive breast cancer patients treated with adjuvant endocrine therapy.","22854050","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","20005069",2010,"Combined tamoxifen and gefitinib in non-small cell lung cancer shows antiproliferative effects.","20005069","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","22147081",2012,"GPER mediates the Egr-1 expression induced by 17?-estradiol and 4-hydroxitamoxifen in breast and endometrial cancer cells.","22147081","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","19969469",2010,"Tumour markers predictive of successful treatment of breast cancer with primary endocrine therapy in patients over 70 years old: a prospective study.","19969469","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","21935603",2012,"The tumor microenvironment modulates tamoxifen resistance in breast cancer: a role for soluble stromal factors and fibronectin through ?1 integrin.","21935603","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","1301400",1992,"An estrogen receptor positive MCF-7 clone that is resistant to antiestrogens and estradiol.","1301400","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","20549698",2011,"p53 status influences response to tamoxifen but not to fulvestrant in breast cancer cell lines.","20549698","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","22922893",2012,"Inhibition of the AKT/mTOR and erbB pathways by gefitinib, perifosine             and analogs of gonadotropin-releasing hormone I and II to overcome tamoxifen resistance             in breast cancer cells.","22922893","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","16831274",2006,"[Involvement of epidermal growth factor receptor signaling pathway in tamoxifen resistance of MCF-7 cells].","16831274","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","3242819",1988,"Regulation of human estrogen receptor gene, epidermal growth factor receptor gene, and oncogenes by estrogen and antiestrogen in MCF-7 breast cancer cells.","3242819","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","24039841",2013,"Estradiol and tamoxifen induce cell migration through GPR30 and activation of focal adhesion kinase (FAK) in endometrial cancers with low or without nuclear estrogen receptor ? (ER?).","24039841","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","16037379",2005,"Insulin-like growth factor-I receptor signaling in tamoxifen-resistant breast cancer: a supporting role to the epidermal growth factor receptor.","16037379","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","16034044",2005,"Tumor-specific expression of vascular endothelial growth factor receptor 2 but not vascular endothelial growth factor or human epidermal growth factor receptor 2 is associated with impaired response to adjuvant tamoxifen in premenopausal breast cancer.","16034044","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","11454885",2001,"Value of epidermal growth factor receptor, HER2, p53, and steroid receptors in predicting the efficacy of tamoxifen in high-risk postmenopausal breast cancer patients.","11454885","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","17416003",2006,"[Relation between c-erbB1, c-erbB2, MAPK expression and resistance to tamoxifen in breast cancer cells in vitro].","17416003","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,1,"EGFR","10542936",1999,"Expression of steroid receptors, Ki-67, and epidermal growth factor receptor in tamoxifen-treated endometrium.","10542936","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","17283173",2007,"Long-term treatment with tamoxifen facilitates translocation of estrogen receptor alpha out of the nucleus and enhances its interaction with EGFR in MCF-7 breast cancer cells.","17283173","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","11559718",2001,"Letrozole is more effective neoadjuvant endocrine therapy than tamoxifen for ErbB-1- and/or ErbB-2-positive, estrogen receptor-positive primary breast cancer: evidence from a phase III randomized trial.","11559718","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","16113104",2005,"Epidermal growth factor receptor/HER2/insulin-like growth factor receptor signalling and oestrogen receptor activity in clinical breast cancer.","16113104","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","19285025",2009,"AIB1 is required for the acquisition of epithelial growth factor receptor-mediated tamoxifen resistance in breast cancer cells.","19285025","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","10463775",1999,"The anti-proliferative effects of tyrosine kinase inhibitors towards tamoxifen-sensitive and tamoxifen-resistant human breast cancer cell lines in relation to the expression of epidermal growth factor receptors (EGF-R) and the inhibition of EGF-R tyrosine kinase.","10463775","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","19288272",2010,"Growth of hormone-dependent MCF-7 breast cancer cells is promoted by constitutive caveolin-1 whose expression is lost in an EGF-R-mediated manner during development of tamoxifen resistance.","19288272","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","21607586",2011,"G-protein-coupled estrogen receptor GPR30 and tamoxifen resistance in breast cancer.","21607586","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","15860267",2005,"Reversal of tamoxifen resistant breast cancer by low dose estrogen therapy.","15860267","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","17363451",2007,"Tamoxifen-induced rapid death of MCF-7 breast cancer cells is mediated via extracellularly signal-regulated kinase signaling and can be abrogated by estrogen.","17363451","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","17332282",2007,"Amplified in breast cancer 1 in human epidermal growth factor receptor - positive tumors of tamoxifen-treated breast cancer patients.","17332282","Tamoxifen","Receptor, Epidermal Growth Factor"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L1796,L1796)","v":"Tamoxifen"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M1796,M1796)","v":"Receptor, Epidermal Growth Factor"},0,0,1,0,"EGFR",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K1796,K1796)","v":"3390830"},1988,"Genetic instability and the development of steroid hormone insensitivity in cultured T 47D human breast cancer cells.","3390830","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","11559715",2001,"Use of ErbB-1 and ErbB-2 to select endocrine therapy for breast cancer: will it play in Peoria?","11559715","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","16261397",2006,"Bidirectional cross talk between ERalpha and EGFR signalling pathways regulates tamoxifen-resistant growth.","16261397","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","18177812",2008,"ERBB2 status and outcome of endocrine treatment.","18177812","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","16497822",2006,"Benefit from adjuvant tamoxifen therapy in primary breast cancer patients according oestrogen receptor, progesterone receptor, EGF receptor and HER2 status.","16497822","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","18000226",2007,"Genomic and nongenomic effects of estrogen signaling in human endometrial cells: involvement of the growth factor receptor signaling downstream AKT pathway.","18000226","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","2463445",1989,"Expression of epidermal growth factor receptors associated with lack of response to endocrine therapy in recurrent breast cancer.","2463445","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","17971534",2007,"Re: Treatment of human epidermal growth factor receptor 2 overexpressing breast cancer xenografts with multiagent human epidermal growth factor receptor targeted therapy.","17971534","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","23722551",2013,"4-Hydroxytamoxifen induces autophagic death through K-Ras degradation.","23722551","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","17947476",2007,"Wwox and Ap2gamma expression levels predict tamoxifen response.","17947476","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","16333527",2006,"Elevated Src activity promotes cellular invasion and motility in tamoxifen resistant breast cancer cells.","16333527","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","16080193",2006,"Tamoxifen resistance in MCF7 cells promotes EMT-like behaviour and involves modulation of beta-catenin phosphorylation.","16080193","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","16322341",2005,"Tamoxifen treatment for breast cancer enforces a distinct gene-expression profile on the human endometrium: an exploratory study.","16322341","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","10601607",2000,"Regulation of estrogen receptor and epidermal growth factor receptor by tamoxifen under high and low estrogen environments in MCF-7 cells grown in athymic mice.","10601607","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","17686159",2007,"Heregulin beta1 drives gefitinib-resistant growth and invasion in tamoxifen-resistant MCF-7 breast cancer cells.","17686159","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","16189183",2005,"Analogs of GnRH-I and GnRH-II inhibit epidermal growth factor-induced signal transduction and resensitize resistant human breast cancer cells to 4OH-tamoxifen.","16189183","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","17636398",2008,"Epidermal growth factor receptor (EGFR) and the estrogen receptor modulator amplified in breast cancer (AIB1) for predicting clinical outcome after adjuvant tamoxifen in breast cancer.","17636398","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","1616857",1992,"Changes in epidermal growth factor receptor expression and response to ligand associated with acquired tamoxifen resistance or oestrogen independence in the ZR-75-1 human breast cancer cell line.","1616857","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,1,"EGFR","17634479",2007,"Quantitative measurement of epidermal growth factor receptor is a negative predictive factor for tamoxifen response in hormone receptor positive premenopausal breast cancer.","17634479","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","18797454",2008,"A new role for tamoxifen in oestrogen receptor-negative breast cancer when it is combined with epigallocatechin gallate.","18797454","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","16145046",2005,"Estrogen receptor-positive, progesterone receptor-negative breast cancer: association with growth factor receptor expression and tamoxifen resistance.","16145046","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","19138696",2009,"Estrogen signals via an extra-nuclear pathway involving IGF-1R and EGFR in tamoxifen-sensitive and -resistant breast cancer cells.","19138696","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","2784313",1989,"Regulation of epidermal growth factor-receptor by estrogen and antiestrogen in the human breast cancer cell line MCF-7.","2784313","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","16990991",2006,"Activation of mitogenic pathways and sensitization to estrogen-induced apoptosis: two independent characteristics of tamoxifen-resistant breast cancer cells?","16990991","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","17106250",2006,"17beta-estradiol and tamoxifen stimulate rapid and transient ERK activationin MCF-7 cells via distinct signaling mechanisms.","17106250","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","23499324",2013,"Estrogen receptor-?36 is involved in development of acquired tamoxifen resistance via regulating the growth status switch in breast cancer cells.","23499324","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","15665275",2005,"The dual ErbB1/ErbB2 inhibitor, lapatinib (GW572016), cooperates with tamoxifen to inhibit both cell proliferation- and estrogen-dependent gene expression in antiestrogen-resistant breast cancer.","15665275","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","1911227",1991,"Influence of the antioestrogen tamoxifen on normal breast tissue.","1911227","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","15494641",2004,"Tamoxifen long-term treatment in vitro alters the apoptotic response of MCF-7 breast cancer cells.","15494641","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","19609946",2010,"Endocrine resistance associated with activated ErbB system in breast cancer cells is reversed by inhibiting MAPK or PI3K/Akt signaling pathways.","19609946","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","19588487",2009,"EGFRvIII-induced estrogen-independence, tamoxifen-resistance phenotype correlates with PgR expression and modulation of apoptotic molecules in breast cancer.","19588487","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","19535242",2009,"Tamoxifen reduces the risk of contralateral breast cancer in premenopausal women: Results from a controlled randomised trial.","19535242","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","19593637",2010,"E-cadherin mediates the aggregation of breast cancer cells induced by tamoxifen and epidermal growth factor.","19593637","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","15721411",2005,"Effects of prolonged tamoxifen treatment on receptor expression and apoptosis of ovarian cancer cells.","15721411","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","9553667",1998,"The anti-proliferative effect of suramin towards tamoxifen-sensitive and resistant human breast cancer cell lines in relation to expression of receptors for epidermal growth factor and insulin-like growth factor-I: growth stimulation in the presence of tamoxifen.","9553667","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","7904139",1993,"Expression of the GST pi gene and response to tamoxifen therapy in locally advanced breast carcinomas.","7904139","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","7912163",1994,"ERBB2 amplification is associated with tamoxifen resistance in steroid-receptor positive breast cancer.","7912163","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","7912565",1994,"Epidermal growth factor receptor expression in breast cancer: association with response to endocrine therapy.","7912565","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","8137282",1994,"Transforming growth factor-alpha and endocrine sensitivity in breast cancer.","8137282","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","7577479",1995,"Expression of ras p21, p53 and c-erbB-2 in advanced breast cancer and response to first line hormonal therapy.","7577479","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","7960234",1994,"Immunocytochemical localization of BCL-2 protein in human breast cancers and its relationship to a series of prognostic markers and response to endocrine therapy.","7960234","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","9815855",1997,"Expression of epidermal growth factor receptor and c-erbB2 during the development of tamoxifen resistance in human breast cancer.","9815855","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","9788438",1998,"c-erbB3 and c-erbB4 expression is a feature of the endocrine responsive phenotype in clinical breast cancer.","9788438","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,1,"EGFR","8616829",1996,"Reduced levels of cathepsin D associated with tamoxifen resistance and estrogen independence in the ZR-75-1 human breast cancer cell line.","8616829","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptor, Epidermal Growth Factor",0,0,1,0,"EGFR","8508397",1993,"Down-regulation of transforming growth factor-alpha by tamoxifen in human breast cancer.","8508397","Tamoxifen","Receptor, Epidermal Growth Factor"]
["Tamoxifen","Receptors, LDL",0,0,1,0,"LDLR","15485695",2004,"Synergistic upregulation of low-density lipoprotein receptor activity by tamoxifen and lovastatin.","15485695","Tamoxifen","Receptors, LDL"]
["Tamoxifen","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","21993004",2011,"Tamoxifen lowers the MMP-9/TIMP-1 ratio and inhibits the invasion capacity of ER-positive non-small cell lung cancer cells.","21993004","Tamoxifen","Matrix Metalloproteinase 9"]
["Tamoxifen","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","19944523",2010,"Increased endostatin generation and decreased angiogenesis via MMP-9 by tamoxifen in hormone dependent ovarian cancer.","19944523","Tamoxifen","Matrix Metalloproteinase 9"]
["Tamoxifen","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","16651433",2006,"Estradiol and tamoxifen regulate endostatin generation via matrix metalloproteinase activity in breast cancer in vivo.","16651433","Tamoxifen","Matrix Metalloproteinase 9"]
["Tamoxifen","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","15696052",2005,"Tamoxifen up-regulates catalase production, inhibits vessel wall neutrophil infiltration, and attenuates development of experimental abdominal aortic aneurysms.","15696052","Tamoxifen","Matrix Metalloproteinase 9"]
["Tamoxifen","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","17031577",2007,"MMP-2 and MMP-9 activity is regulated by estradiol and tamoxifen in cultured human breast cancer cells.","17031577","Tamoxifen","Matrix Metalloproteinase 9"]
["Tamoxifen","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","24377619",2013,"Synergistic effects of tamoxifen and tranilast on VEGF and MMP-9 regulation in cultured human breast cancer cells.","24377619","Tamoxifen","Matrix Metalloproteinase 9"]
["Tamoxifen","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","16243802",2005,"How ADAM-9 and ADAM-11 differentially from estrogen receptor predict response to tamoxifen treatment in patients with recurrent breast cancer: a retrospective study.","16243802","Tamoxifen","Matrix Metalloproteinase 9"]
["Tamoxifen","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","18996114",2009,"Tamoxifen decreases extracellular TGF-beta1 secreted from breast cancer cells--a post-translational regulation involving matrix metalloproteinase activity.","18996114","Tamoxifen","Matrix Metalloproteinase 9"]
["Tamoxifen","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","25075039",2014,"Metformin inhibits tumor cell migration via down-regulation of MMP9 in tamoxifen-resistant breast cancer cells.","25075039","Tamoxifen","Matrix Metalloproteinase 9"]
["Tamoxifen","NF-E2-Related Factor 2",0,0,1,0,"NFE2L2","18539158",2008,"Increased expression of Nrf2/ARE-dependent anti-oxidant proteins in tamoxifen-resistant breast cancer cells.","18539158","Tamoxifen","NF-E2-Related Factor 2"]
["Tamoxifen","Receptors, Urokinase Plasminogen Activator",0,0,1,0,"PLAUR","15231667",2004,"Urokinase-type plasminogen activator system in breast cancer: association with tamoxifen therapy in recurrent disease.","15231667","Tamoxifen","Receptors, Urokinase Plasminogen Activator"]
["Tamoxifen","Receptors, Urokinase Plasminogen Activator",0,0,1,0,"PLAUR","9270032",1997,"Prevention of breast cancer growth, invasion, and metastasis by antiestrogen tamoxifen alone or in combination with urokinase inhibitor B-428.","9270032","Tamoxifen","Receptors, Urokinase Plasminogen Activator"]
["Tamoxifen","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","22052053",2012,"Antifibrotic effect of tamoxifen in a model of progressive renal disease.","22052053","Tamoxifen","Plasminogen Activator Inhibitor 1"]
["Tamoxifen","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","15231667",2004,"Urokinase-type plasminogen activator system in breast cancer: association with tamoxifen therapy in recurrent disease.","15231667","Tamoxifen","Plasminogen Activator Inhibitor 1"]
["Tamoxifen","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","10899650",2000,"The role of cathepsin D and PAI-1 in primary invasive breast cancer as prognosticators and predictors of treatment benefit with adjuvant tamoxifen.","10899650","Tamoxifen","Plasminogen Activator Inhibitor 1"]
["Tamoxifen","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","7563153",1995,"Urokinase-type plasminogen activator and its inhibitor PAI-1: predictors of poor response to tamoxifen therapy in recurrent breast cancer.","7563153","Tamoxifen","Plasminogen Activator Inhibitor 1"]
["Tamoxifen","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","11368663",2001,"Effect of tamoxifen on transforming growth factor beta1 production by keloid and fetal fibroblasts.","11368663","Tamoxifen","Transforming Growth Factor beta1"]
["Tamoxifen","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","12657824",2003,"[The effects of tamoxifen on human hepatocellular carcinoma cell proliferation and transforming growth factor-beta1 expression].","12657824","Tamoxifen","Transforming Growth Factor beta1"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L1860,L1860)","v":"Tamoxifen"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M1860,M1860)","v":"Transforming Growth Factor beta1"},0,0,1,0,"TGFB1",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K1860,K1860)","v":"16513256"},2007,"The role of tamoxifen in combination with cisplatin on oral squamous cell carcinoma cell lines.","16513256","Tamoxifen","Transforming Growth Factor beta1"]
["Tamoxifen","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","19636578",2010,"Topical tamoxifen therapy in hypertrophic scars or keloids in burns.","19636578","Tamoxifen","Transforming Growth Factor beta1"]
["Tamoxifen","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","15640959",2004,"Early nuclear alterations and immunohistochemical expression of Ki-67, Erb-B2, vascular endothelial growth factor (VEGF), transforming growth factor (TGF-beta1) and integrine-linked kinase (ILK) two days after tamoxifen in breast carcinoma.","15640959","Tamoxifen","Transforming Growth Factor beta1"]
["Tamoxifen","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","22052053",2012,"Antifibrotic effect of tamoxifen in a model of progressive renal disease.","22052053","Tamoxifen","Transforming Growth Factor beta1"]
["Tamoxifen","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","15618244",2005,"Effects of progesterone and selective oestrogen receptor modulators on chronic allograft nephropathy in rats.","15618244","Tamoxifen","Transforming Growth Factor beta1"]
["Tamoxifen","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","18564211",2009,"Antifibrogenic effects of tamoxifen in a rat model of periportal hepatic fibrosis.","18564211","Tamoxifen","Transforming Growth Factor beta1"]
["Tamoxifen","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","12680217",2003,"Effects of tamoxifen on transcriptional level of transforming growth factor beta (TGF-beta) isoforms 1 and 2 in tumor tissue during primary treatment of patients with breast cancer.","12680217","Tamoxifen","Transforming Growth Factor beta1"]
["Tamoxifen","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","12851686",2003,"Induction of antiproliferation and apoptosis in estrogen receptor negative MDA-231 human breast cancer cells by mifepristone and 4-hydroxytamoxifen combination therapy: a role for TGFbeta1.","12851686","Tamoxifen","Transforming Growth Factor beta1"]
["Tamoxifen","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","15448735",2004,"Can transforming growth factor-beta1 and retinoids modify the activity of estradiol and antiestrogens in MCF-7 breast cancer cells?.","15448735","Tamoxifen","Transforming Growth Factor beta1"]
["Tamoxifen","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","23211136",2013,"Effects of tamoxifen citrate on postoperative intra-abdominal adhesion in a rat model.","23211136","Tamoxifen","Transforming Growth Factor beta1"]
["Tamoxifen","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","15762036",2004,"Effects of 17beta-estradiol, tamoxifen and raloxifene on the protein and mRNA expression of interleukin-6, transforming growth factor-beta1 and insulin-like growth factor-1 in primary human osteoblast cultures.","15762036","Tamoxifen","Transforming Growth Factor beta1"]
["Tamoxifen","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","12820425",2003,"Brief tamoxifen pretreatment enhances the chemosensitivity of gastric carcinoma cells to 5-fluorouracil in vitro.","12820425","Tamoxifen","Transforming Growth Factor beta1"]
["Tamoxifen","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","18996114",2009,"Tamoxifen decreases extracellular TGF-beta1 secreted from breast cancer cells--a post-translational regulation involving matrix metalloproteinase activity.","18996114","Tamoxifen","Transforming Growth Factor beta1"]
["Tamoxifen","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","23637793",2013,"Tamoxifen ameliorates peritoneal membrane damage by blocking mesothelial to mesenchymal transition in peritoneal dialysis.","23637793","Tamoxifen","Transforming Growth Factor beta1"]
["Tamoxifen","Thrombomodulin",0,0,1,1,"THBD","15520062",2004,"Tamoxifen-induced tissue factor pathway inhibitor reduction: a clue for an acquired thrombophilic state?","15520062","Tamoxifen","Thrombomodulin"]
["Tamoxifen","Tissue Inhibitor of Metalloproteinase-1",0,0,1,0,"TIMP1","18443351",2008,"Serum TIMP-1 and response to the aromatase inhibitor letrozole versus tamoxifen in metastatic breast cancer.","18443351","Tamoxifen","Tissue Inhibitor of Metalloproteinase-1"]
["Tamoxifen","Tissue Inhibitor of Metalloproteinase-1",0,0,1,0,"TIMP1","17031577",2007,"MMP-2 and MMP-9 activity is regulated by estradiol and tamoxifen in cultured human breast cancer cells.","17031577","Tamoxifen","Tissue Inhibitor of Metalloproteinase-1"]
["Tamoxifen","Tissue Inhibitor of Metalloproteinase-1",0,0,1,0,"TIMP1","18407793",2008,"Anti-angiogenic potential of CoenzymeQ10, riboflavin and niacin in breast cancer patients undergoing tamoxifen therapy.","18407793","Tamoxifen","Tissue Inhibitor of Metalloproteinase-1"]
["Tamoxifen","Tissue Inhibitor of Metalloproteinase-1",0,0,1,0,"TIMP1","21993004",2011,"Tamoxifen lowers the MMP-9/TIMP-1 ratio and inhibits the invasion capacity of ER-positive non-small cell lung cancer cells.","21993004","Tamoxifen","Tissue Inhibitor of Metalloproteinase-1"]
["Tannins","Chemokine CCL2",0,0,0,0,"CCL2","10706387",2000,"Inhibitory effect of sanguiin H-11 on chemotaxis of neutrophil.","10706387","Tannins","Chemokine CCL2"]
["Tannins","Receptor, Epidermal Growth Factor",0,0,0,0,"EGFR","16567414",2006,"Tannic acid, a potent inhibitor of epidermal growth factor receptor tyrosine kinase.","16567414","Tannins","Receptor, Epidermal Growth Factor"]
["Tannins","Receptor, Epidermal Growth Factor",0,0,0,0,"EGFR","16153407",2005,"Inhibition of epidermal growth factor-induced cell transformation by tannins.","16153407","Tannins","Receptor, Epidermal Growth Factor"]
["Tannins","Receptors, LDL",0,0,0,0,"LDLR","21985572",2012,"Effect of phlorotannins from Sargassum thunbergii on blood lipids regulation in mice with high-fat diet.","21985572","Tannins","Receptors, LDL"]
["Tannins","Matrix Metalloproteinase 9",0,0,0,0,"MMP9","12398898",2002,"Penta-O-galloyl-beta-D-glucose inhibits the invasion of mouse melanoma by suppressing metalloproteinase-9 through down-regulation of activator protein-1.","12398898","Tannins","Matrix Metalloproteinase 9"]
["Tannins","Matrix Metalloproteinase 9",0,0,0,0,"MMP9","15823585",2005,"Suppression of tumor cell invasiveness by hydrolyzable tannins (plant polyphenols) via the inhibition of matrix metalloproteinase-2/-9 activity.","15823585","Tannins","Matrix Metalloproteinase 9"]
["Tannins","Matrix Metalloproteinase 9",0,0,0,0,"MMP9","19024098",2008,"Mitigated calcification of glutaraldehyde-fixed bovine pericardium by tannic acid in rats.","19024098","Tannins","Matrix Metalloproteinase 9"]
["Tannins","Matrix Metalloproteinase 9",0,0,0,0,"MMP9","15670892",2005,"Inhibition of Caco-2 colon, MCF-7 and Hs578T breast, and DU 145 prostatic cancer cell proliferation by water-soluble black bean condensed tannins.","15670892","Tannins","Matrix Metalloproteinase 9"]
["Tannins","Matrix Metalloproteinase 9",0,0,0,0,"MMP9","9160354",1996,"Inhibition by galloylglucose (GG6-10) of tumor invasion through extracellular matrix and gelatinase-mediated degradation of type IV collagens by metastatic tumor cells.","9160354","Tannins","Matrix Metalloproteinase 9"]
["Testosterone Propionate","Receptors, LDL",1,0,1,1,"LDLR","22539767",2012,"Transient exposure of neonatal female mice to testosterone abrogates the sexual dimorphism of abdominal aortic aneurysms.","22539767","Testosterone Propionate","Receptors, LDL"]
["Testosterone Propionate","NF-E2-Related Factor 2",1,0,1,0,"NFE2L2","23756138",2013,"Chronic testosterone propionate supplement could activated the Nrf2-ARE pathway in the brain and ameliorated the behaviors of aged rats.","23756138","Testosterone Propionate","NF-E2-Related Factor 2"]
["Theobromine","Plasminogen Activator Inhibitor 1",0,0,1,0,"SERPINE1","9850731",1998,"Inhibitory effect of theobromine on induction of angiogenesis and VEGF mRNA expression in v-raf transfectants of human urothelial cells HCV-29.","9850731","Theobromine","Plasminogen Activator Inhibitor 1"]
["Theophylline","Macrophage Colony-Stimulating Factor",0,0,1,0,"CSF1","1689293",1990,"Inhibition of the signaling pathways for macrophage proliferation by cyclic AMP. Lack of effect on early responses to colony stimulating factor-1.","1689293","Theophylline","Macrophage Colony-Stimulating Factor"]
["Theophylline","Matrix Metalloproteinase 9",0,0,1,0,"MMP9","22287608",2012,"Inhibitory effects of theophylline on the peroxynitrite-augmented release of matrix metalloproteinases by lung fibroblasts.","22287608","Theophylline","Matrix Metalloproteinase 9"]
["Theophylline","Transforming Growth Factor beta1",0,0,1,1,"TGFB1","12180796",2002,"Immunohistochemical study on inducible type of nitric oxide (iNOS), basic fibroblast growth factor (bFGF) and tumor growth factor-beta1 (TGF-beta1) in arteritis induced in rats by fenoldopam and theophylline, vasodilators.","12180796","Theophylline","Transforming Growth Factor beta1"]
["Theophylline","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","22287608",2012,"Inhibitory effects of theophylline on the peroxynitrite-augmented release of matrix metalloproteinases by lung fibroblasts.","22287608","Theophylline","Transforming Growth Factor beta1"]
["Theophylline","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","12771548",2003,"Theophylline attenuates the adhesion of eosinophils to endothelial cells.","12771548","Theophylline","Vascular Cell Adhesion Molecule-1"]
["Theophylline","Vascular Cell Adhesion Molecule-1",0,0,1,0,"VCAM1","7514535",1994,"Methylxanthines and calcium-mobilizing agents inhibit the expression of cytokine-inducible nitric oxide synthase and vascular cell adhesion molecule-1 in murine microvascular endothelial cells.","7514535","Theophylline","Vascular Cell Adhesion Molecule-1"]
["Tretinoin","Chemokine CCL2",1,0,1,0,"CCL2","14660485",2004,"Retinoic acid inhibits interleukin-4-induced eotaxin production in a human bronchial epithelial cell line.","14660485","Tretinoin","Chemokine CCL2"]
["Tretinoin","Chemokine CCL2",1,0,1,0,"CCL2","10479651",1999,"9-cis retinoic acid induces monocyte chemoattractant protein-1 secretion in human monocytic THP-1 cells.","10479651","Tretinoin","Chemokine CCL2"]
["Tretinoin","Chemokine CCL2",1,0,1,0,"CCL2","22464761",2012,"Retinoic acid suppresses growth of lesions, inhibits peritoneal cytokine secretion, and promotes macrophage differentiation in an immunocompetent mouse model of endometriosis.","22464761","Tretinoin","Chemokine CCL2"]
["Tretinoin","Chemokine CCL2",1,0,1,0,"CCL2","10542218",1999,"trans-Retinoic acid blocks platelet-derived growth factor-BB-induced expression of the murine monocyte chemoattractant-1 gene by blocking the assembly of a promoter proximal Sp1 binding site.","10542218","Tretinoin","Chemokine CCL2"]
["Tretinoin","Chemokine CCL2",1,0,1,0,"CCL2","1365641",1992,"Monocyte chemoattractant protein-1 (MCP-1) expression in human articular cartilage. Induction by peptide regulatory factors and differential effects of dexamethasone and retinoic acid.","1365641","Tretinoin","Chemokine CCL2"]
["Tretinoin","Chemokine CCL2",1,0,1,1,"CCL2","18216048",2008,"Monocyte chemotactic protein-1 in the migration of differentiated leukaemic cells toward alveolar epithelial cells.","18216048","Tretinoin","Chemokine CCL2"]
["Tretinoin","Chemokine CCL2",1,0,1,0,"CCL2","16412693",2006,"Anti-inflammatory effect of all-trans-retinoic acid in inflammatory arthritis.","16412693","Tretinoin","Chemokine CCL2"]
["Tretinoin","Chemokine CCL2",1,0,1,0,"CCL2","11274229",2001,"Suppression of constitutive but not Il-1beta-inducible expression of monocyte chemoattractant protein-1 in mesangial cells by retinoic acids: intervention in the activator protein-1 pathway.","11274229","Tretinoin","Chemokine CCL2"]
["Tretinoin","Chemokine CCL2",1,0,1,0,"CCL2","22950813",2013,"Inflammation induced by lipopolysaccharide does not prevent the vitamin A and retinoic acid-induced increase in retinyl ester formation in neonatal rat lungs.","22950813","Tretinoin","Chemokine CCL2"]
["Tretinoin","Chemokine CCL2",1,0,1,0,"CCL2","18926686",2009,"Retinoic acid dampens LPS-induced NF-kappaB activity: results from human monoblasts and in vivo imaging of NF-kappaB reporter mice.","18926686","Tretinoin","Chemokine CCL2"]
["Tretinoin","Chemokine CCL2",1,0,1,0,"CCL2","12058867",2002,"1Alpha25(OH)2D3 interferes with retinoic acid-induced inhibition of c-fos gene expression for AP-1 formation in osteoblastic cells.","12058867","Tretinoin","Chemokine CCL2"]
["Tretinoin","Chemokine CCL2",1,0,1,0,"CCL2","21228601",2011,"Therapeutic effect of retinoic acid on unilateral ureteral obstruction model.","21228601","Tretinoin","Chemokine CCL2"]
["Tretinoin","Chemokine CCL2",1,0,1,0,"CCL2","22820162",2012,"Retinoic acid and tumor necrosis factor-? induced monocytic cell gene expression is regulated in part by induction of transcription factor MafB.","22820162","Tretinoin","Chemokine CCL2"]
["Tretinoin","Chemokine CCL2",1,0,1,0,"CCL2","16096774",2005,"[Antiangiogenic and anti-immunosuppressive therapeutic strategies in human head and neck squamous cell carcinoma (HNSCC)].","16096774","Tretinoin","Chemokine CCL2"]
["Tretinoin","Chemokine CCL2",1,0,1,0,"CCL2","19017957",2008,"Retinoic acids are potent inhibitors of spontaneous human eosinophil apoptosis.","19017957","Tretinoin","Chemokine CCL2"]
["Tretinoin","Chemokine CCL2",1,0,1,0,"CCL2","15606616",2005,"The beneficial effects of treatment with all-trans-retinoic acid plus corticosteroid on autoimmune nephritis in NZB/WF mice.","15606616","Tretinoin","Chemokine CCL2"]
["Tretinoin","Chemokine CCL2",1,0,1,0,"CCL2","15550114",2004,"Effect of retinoic acid in experimental diabetic nephropathy.","15550114","Tretinoin","Chemokine CCL2"]
["Tretinoin","Chemokine CCL2",1,0,1,0,"CCL2","19828696",2009,"Chemokine induction by all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia: triggering the differentiation syndrome.","19828696","Tretinoin","Chemokine CCL2"]
["Tretinoin","Chemokine CCL2",1,0,1,0,"CCL2","7919389",1994,"Monocyte chemoattractant protein-1 gene is expressed in activated neutrophils and retinoic acid-induced human myeloid cell lines.","7919389","Tretinoin","Chemokine CCL2"]
["Tretinoin","Chemokine CCL2",1,0,1,0,"CCL2","8063765",1994,"Retinoic acid suppression of c-fos gene inhibits expression of tumor necrosis factor-alpha-induced monocyte chemoattractant JE/MCP-1 in clonal osteoblastic MC3T3-E1 cells.","8063765","Tretinoin","Chemokine CCL2"]
["Tretinoin","Antigens, CD40",1,0,1,0,"CD40","15883744",2005,"Retinoic acid inhibits CD40 plus IL-4 mediated IgE production through alterations of sCD23, sCD54 and IL-6 production.","15883744","Tretinoin","Antigens, CD40"]
["Tretinoin","Antigens, CD40",1,0,1,0,"CD40","15695403",2005,"Retinoic acid inhibits the proliferative response induced by CD40 activation and interleukin-4 in mantle cell lymphoma.","15695403","Tretinoin","Antigens, CD40"]
["Tretinoin","Antigens, CD40",1,0,1,0,"CD40","11776968",2001,"Expression of surface CD40 and immunocytochemical actin-bundling protein fascin in dendritic cells from multiple myeloma treated with retinoids during their differentiation in vitro.","11776968","Tretinoin","Antigens, CD40"]
["Tretinoin","Antigens, CD40",1,0,1,0,"CD40","18082674",2007,"Retinoic acid promotes mouse splenic B cell surface IgG expression and maturation stimulated by CD40 and IL-4.","18082674","Tretinoin","Antigens, CD40"]
["Tretinoin","Antigens, CD40",1,0,1,0,"CD40","9716600",1998,"Retinoic acid inhibits CD40 + interleukin-4-mediated IgE production in vitro.","9716600","Tretinoin","Antigens, CD40"]
["Tretinoin","Antigens, CD40",1,0,1,0,"CD40","8690713",1995,"Induction of CD40 in promyelocytic HL60 cells cultured with retinoic acid and/or various cytokines.","8690713","Tretinoin","Antigens, CD40"]
["Tretinoin","Collagen Type III",1,0,1,0,"COL3A1","16539842",2006,"All-trans retinoic acid inhibited angiotensin II-induced increase in cell growth and collagen secretion of neonatal cardiac fibroblasts.","16539842","Tretinoin","Collagen Type III"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L1924,L1924)","v":"Tretinoin"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M1924,M1924)","v":"Macrophage Colony-Stimulating Factor"},1,0,1,0,"CSF1",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K1924,K1924)","v":"19017957"},2008,"Retinoic acids are potent inhibitors of spontaneous human eosinophil apoptosis.","19017957","Tretinoin","Macrophage Colony-Stimulating Factor"]
["Tretinoin","Macrophage Colony-Stimulating Factor",1,0,1,0,"CSF1","10554038",1999,"Effect of all-trans-retinoic acid on c-fms proto-oncogene [colony-stimulating factor 1 (CSF-1) receptor] expression and CSF-1-induced invasion and anchorage-independent growth of human breast carcinoma cells.","10554038","Tretinoin","Macrophage Colony-Stimulating Factor"]
["Tretinoin","Macrophage Colony-Stimulating Factor",1,0,1,0,"CSF1","1372669",1992,"Self-renewal inhibition of acute myeloid leukemia clonogenic cells by biological inducers of differentiation.","1372669","Tretinoin","Macrophage Colony-Stimulating Factor"]
["Tretinoin","Macrophage Colony-Stimulating Factor",1,0,1,0,"CSF1","2015403",1991,"Two-step differentiation of AML-193 leukemic line: terminal maturation is induced by positive interaction of retinoic acid with granulocyte colony-stimulating factor (CSF) and vitamin D3 with monocyte CSF.","2015403","Tretinoin","Macrophage Colony-Stimulating Factor"]
["Tretinoin","Macrophage Colony-Stimulating Factor",1,0,1,0,"CSF1","7994028",1994,"Retinoids (all-trans and 9-cis retinoic acid) stimulate production of macrophage colony-stimulating factor and granulocyte-macrophage colony-stimulating factor by human bone marrow stromal cells.","7994028","Tretinoin","Macrophage Colony-Stimulating Factor"]
["Tretinoin","Macrophage Colony-Stimulating Factor",1,0,1,0,"CSF1","7889981",1994,"Expression of activated RAF accelerates cell differentiation and RB protein down-regulation but not hypophosphorylation.","7889981","Tretinoin","Macrophage Colony-Stimulating Factor"]
["Tretinoin","Macrophage Colony-Stimulating Factor",1,0,1,0,"CSF1","9616179",1998,"Retinoic acid inhibits monocyte to macrophage survival and differentiation.","9616179","Tretinoin","Macrophage Colony-Stimulating Factor"]
["Tretinoin","Macrophage Colony-Stimulating Factor",1,0,1,0,"CSF1","8445950",1993,"All-trans retinoic acid induces monocyte growth factor receptor (c-fms) gene expression in HL-60 leukemia cells.","8445950","Tretinoin","Macrophage Colony-Stimulating Factor"]
["Tretinoin","Chemokine CXCL10",1,0,1,0,"CXCL10","21725974",2011,"Genome-wide transcriptional profiling analysis of all trans retinoic acid-treated tongue carcinoma SCC-9 cells.","21725974","Tretinoin","Chemokine CXCL10"]
["Tretinoin","Chemokine CXCL10",1,0,1,0,"CXCL10","18989765",2008,"Effects of all-trans retinoic acid on Th1- and Th2-related chemokines production in monocytes.","18989765","Tretinoin","Chemokine CXCL10"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","3260878",1988,"EGF receptor expression in the developing tooth is altered by exogenous retinoic acid and EGF.","3260878","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","2169350",1990,"Ligand-activated thyroid hormone and retinoic acid receptors inhibit growth factor receptor promoter expression.","2169350","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","2250947",1990,"[Effect of retinoids on the growth of corneal endothelial cells in culture].","2250947","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","1748717",1991,"Dexamethasone and retinoic acid regulate the expression of epidermal growth factor receptor mRNA by distinct mechanisms.","1748717","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","3262523",1988,"Specificity in the synergism between retinoic acid and EGF on the growth of adult human skin fibroblasts.","3262523","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","3185568",1988,"Accumulation of epidermal growth factor receptors in retinoic acid-treated fetal rat lung cells is due to enhanced receptor synthesis.","3185568","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","23974111",2013,"EGFR inhibitors exacerbate differentiation and cell cycle arrest induced by retinoic acid and vitamin D3 in acute myeloid leukemia cells.","23974111","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","12490307",2003,"Tyrphostins and retinoids cooperate during inhibition of in vitro growth of ovarian cancer cells.","12490307","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","1389683",1992,"Suppression by retinoic acid of epidermal growth factor receptor autophosphorylation and glycosylation in cultured human head and neck squamous carcinoma cells.","1389683","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","11801540",2002,"Evidence for the epidermal growth factor receptor as a target for lung cancer prevention.","11801540","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","19787411",2010,"The proliferative effects of retinoic acid on primary cultures of adult rat type II pneumocytes depend upon cell density.","19787411","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","10075925",1999,"Identification of heparin-binding EGF-like growth factor as a target in intercellular regulation of epidermal basal cell growth by suprabasal retinoic acid receptors.","10075925","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","12069693",2002,"Androgen and retinoic acid interaction in LNCaP cells, effects on cell proliferation and expression of retinoic acid receptors and epidermal growth factor receptor.","12069693","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","2340496",1990,"Epidermal growth factor receptor expression in a retinoic acid-treated human melanoma cell line.","2340496","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","2307713",1990,"Inhibition of epidermal growth factor receptor activity by retinoic acid in glioma cells.","2307713","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","11886492",2001,"Heparin-binding epidermal-growth-factor-like growth factor activation of keratinocyte ErbB receptors Mediates epidermal hyperplasia, a prominent side-effect of retinoid therapy.","11886492","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","10459851",1999,"Retinoid and androgen regulation of cell growth, epidermal growth factor and retinoic acid receptors in normal and carcinoma rat prostate cells.","10459851","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","15341973",2004,"Targeted therapy--how successful has it been?","15341973","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","11746830",2001,"Decreased mitogenic response to epidermal growth factor in human squamous cell carcinoma lines overexpressing epidermal growth factor receptor owing to limiting amounts of the adaptor protein Grb2: rescue by retinoic acid treatment.","11746830","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","3499133",1987,"Effects of retinoic acid on receptors for epidermal growth factor in mouse palatal mesenchymal cells in vitro.","3499133","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","11801531",2002,"Lung cancer prevention: retinoids and the epidermal growth factor receptor-a phoenix rising?","11801531","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","2297769",1990,"Modulation of epidermal growth factor receptors by retinoic acid in ME180 cells.","2297769","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","3168791",1988,"Retinoic acid alters EGF receptor expression during palatogenesis.","3168791","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","2373180",1990,"Retinoids enhance the number of EGF receptors in corneal endothelial cells.","2373180","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","20421725",2010,"All-trans retinoic acid (ATRA) downregulates MMP-9 by modulating its regulatory molecules.","20421725","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","2288880",1990,"Characterization of epidermal growth factor receptor induction by retinoic acid in a chemically transformed rat liver cell line.","2288880","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","1310606",1992,"Evaluation of the actions and interactions of retinoic acid and epidermal growth factor on transformed urothelial cells in culture: implications for the use of retinoid therapy in the treatment of bladder cancer patients.","1310606","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","1657191",1991,"Retinoic acid receptor in subclone of human salivary gland adenocarcinoma cell line HSG and effect of retinoic acid on cellular growth.","1657191","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","3040236",1987,"Differential responsiveness of normal and simian virus 40-transformed BALB/c 3T3 cells to retinoic acid: rapid enhancement of epidermal growth factor receptor binding in a simian virus 40-3T3 variant.","3040236","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","2881627",1987,"Inconsistent effects of all-trans retinoic acid on different clones of chemically transformed rat liver epithelial cells.","2881627","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","17943186",2008,"All-trans retinoic acid-induced hyaluronan production and hyperplasia are partly mediated by EGFR signaling in epidermal keratinocytes.","17943186","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","18451248",2008,"Synergistic growth inhibition by 9-cis-retinoic acid plus trastuzumab in human hepatocellular carcinoma cells.","18451248","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","16302920",2005,"Retinoic acid is a potential negative regulator for differentiation of human periodontal ligament cells.","16302920","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","2883052",1987,"Commitment to differentiation induced by retinoic acid in P19 embryonal carcinoma cells is cell cycle dependent.","2883052","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","1855550",1991,"Retinoic acid decreases the number of EGF receptors in corneal epithelium and Chang conjunctival cells.","1855550","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","16357442",2005,"Soluble form of heparin-binding EGF-like growth factor contributes to retinoic acid-induced epidermal hyperplasia.","16357442","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","10816385",2000,"Retinoic acid affects the EGF-R signaling pathway during differentiation induction of human endometrial adenocarcinoma cells.","10816385","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","2783693",1989,"Regulation of epidermal growth factor receptor gene expression by retinoic acid and epidermal growth factor.","2783693","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","18636178",2008,"Nicotinamide attenuates aquaporin 3 overexpression induced by retinoic acid through inhibition of EGFR/ERK in cultured human skin keratinocytes.","18636178","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","21214951",2011,"Dual induction of caspase 3- and transglutaminase-dependent apoptosis by acyclic retinoid in hepatocellular carcinoma cells.","21214951","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,1,"EGFR","2734792",1989,"Cellular alterations and enhanced induction of cleft palate after coadministration of retinoic acid and TCDD.","2734792","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","2788413",1989,"EGF-induced PGE2 release is synergistically enhanced in retinoic acid treated fetal rat lung cells.","2788413","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","2993004",1985,"Biosynthesis of EGF receptor, transferrin receptor and colligin by cultured human keratinocytes and the effect of retinoic acid.","2993004","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","14871993",2004,"Effects of acyclic retinoid on growth, cell cycle control, epidermal growth factor receptor signaling, and gene expression in human squamous cell carcinoma cells.","14871993","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","3017743",1986,"Action of retinoic acid on the diacylglycerol-induced ornithine decarboxylase activity, reduction in EGF binding and protein kinase C activation in rat tracheal epithelial 2C5 cells.","3017743","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","2164349",1990,"Retinoic acid and epidermal growth factor binding in retinoid-mediated invasion suppressed human lung carcinoma cells.","2164349","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","1515368",1992,"Transcriptional control of epidermal growth factor receptor by retinoic acid.","1515368","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","3007486",1986,"Transforming growth factor-beta and retinoic acid modulate phenotypic transformation of normal rat kidney cells induced by epidermal growth factor and platelet-derived growth factor.","3007486","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","2912547",1989,"Modulation of growth and epidermal growth factor receptor activity by retinoic acid in human glioma cells.","2912547","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","11383815",2001,"Retinoic acid enhances lung growth after pneumonectomy.","11383815","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","2613750",1989,"Modulation of transforming growth factor alpha-dependent expression of epidermal growth factor receptor gene by transforming growth factor beta, triiodothyronine, and retinoic acid.","2613750","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","16473924",2006,"Retinoic acid can induce markers of endocrine transdifferentiation in pancreatic ductal adenocarcinoma: preliminary observations from an in vitro cell line model.","16473924","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","2987698",1985,"Selective inhibition of the anchorage-independent growth of myc-transfected fibroblasts by retinoic acid.","2987698","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","2981174",1985,"Lack of correlation between loss of anchorage-independent growth and levels of transformation-specific p53 protein in retinoic acid-treated F9 embryonal carcinoma cells.","2981174","Tretinoin","Receptor, Epidermal Growth Factor"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L1988,L1988)","v":"Tretinoin"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M1988,M1988)","v":"Receptor, Epidermal Growth Factor"},1,0,1,0,"EGFR",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K1988,K1988)","v":"2575317"},1989,"13-cis retinoic acid and dexamethasone modulate the gene expression of epidermal growth factor receptor and fibroblast proteoglycan 40 core protein in human skin fibroblasts.","2575317","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","12595744",2002,"N-(4-hydroxyphenyl)-retinamide selectively increases All-TRANS retinoic acid inhibitory effects in HER2/NEU-overexpressing breast cancer cells.","12595744","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","24480385",2014,"Retinoids and breast cancer: from basic studies to the clinic and back again.","24480385","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,1,"EGFR","1812132",1991,"Retinoic acid alters epithelial differentiation during palatogenesis.","1812132","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","7905817",1994,"Modulation of EGF receptor and CD15 (Lewisx) antigen on the cell surface of breast carcinoma cell lines induced by cytokines, retinoic acid, 12-O-tetradecanoylphorbol 13-acetate and 1,25(OH)2-vitamin D3.","7905817","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","9065807",1997,"Retinoic acid and N-(4-hydroxy-phenyl) retinamide suppress growth of esophageal squamous carcinoma cell lines.","9065807","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","8661485",1996,"Retinoids modulate the effect of PTH and calcitriol on EGF receptor expression in UMR 106-01 cells.","8661485","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","7991046",1994,"Retinoic acid enhances the number of epidermal growth factor receptors in rat glomerular epithelial cells in vitro.","7991046","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,1,"EGFR","9020476",1997,"Multifactorial mechanism for the potentiation of cisplatin (CDDP) cytotoxicity by all-trans retinoic acid (ATRA) in human ovarian carcinoma cell lines.","9020476","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","6266308",1981,"Action of retinoids and phorbol esters on cell growth and the binding of epidermal growth factor.","6266308","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","6282898",1982,"Effects of retinoic acid on the binding and mitogenic activity of epidermal growth factor.","6282898","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","9770378",1998,"Transcriptional regulation of the EGF receptor promoter by HPV16 and retinoic acid in human ectocervical epithelial cells.","9770378","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","6299539",1983,"Action of epidermal growth factor and retinoids on anchorage-dependent and -independent growth of nontransformed rat kidney cells.","6299539","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","7895857",1994,"Modulation of cell surface EGF receptor and HLA expression on glioma cell lines induced with cytokines and differentiation promoters.","7895857","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","9774681",1998,"Integration of growth factor, extracellular matrix, and retinoid signals during bronchial epithelial cell differentiation.","9774681","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","6322983",1984,"Antagonistic actions of retinoic acid and dexamethasone on anchorage-independent growth and epidermal growth factor binding of normal rat kidney cells.","6322983","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","8749714",1995,"Phosphorylation of eIF-4E and initiation of protein synthesis in P19 embryonal carcinoma cells.","8749714","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","8741214",1996,"Retinoic acid-induced RB (retinoblastoma) hypophosphorylation enhanced by CGP 52411 (4,5-dianilinophthalimide), an EGF family tyrosine kinase receptor inhibitor.","8741214","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","9502786",1998,"Retinoic acid inhibits induction of c-Jun protein by ultraviolet radiation that occurs subsequent to activation of mitogen-activated protein kinase pathways in human skin in vivo.","9502786","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,1,"EGFR","7859922",1994,"Nuclear retinoic acid receptor characterization in cultured human trophoblast cells: effect of retinoic acid on epidermal growth factor receptor expression.","7859922","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","6288114",1982,"Effect of retinoic acid and 12-O-tetradecanoyl phorbol-13-acetate on the binding of epidermal growth factor to its cellular receptors.","6288114","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","8269032",1993,"Involvement of transforming growth factor-alpha and its receptor in the growth response of cultured human epidermal cells to retinoic acid.","8269032","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","9449242",1997,"LNCaP prostatic adenocarcinoma cells derived from low and high passage numbers display divergent responses not only to androgens but also to retinoids.","9449242","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","8619789",1996,"Apoptosis in human hepatoma cell line induced by 4,5-didehydro geranylgeranoic acid (acyclic retinoid) via down-regulation of transforming growth factor-alpha.","8619789","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","6245371",1980,"Retinoids specifically enhance the number of epidermal growth factor receptors.","6245371","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","8127013",1994,"Regulation of human renal adenocarcinoma cell growth by retinoic acid and its interactions with epidermal growth factor.","8127013","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","8241025",1993,"Retroviral gene transfer of epidermal growth factor receptor into HL60 cells results in a partial block of retinoic acid-induced granulocytic differentiation.","8241025","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","8104440",1993,"Co-amplification of erbB2, topoisomerase II alpha and retinoic acid receptor alpha genes in breast cancer and allelic loss at topoisomerase I on chromosome 20.","8104440","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","8250033",1993,"Regulation of epidermal growth factor receptor expression and growth by protein kinase C and retinoic acid in LLC-PK1 cells.","8250033","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","8402622",1993,"Human papillomavirus 16 immortalization of normal human ectocervical epithelial cells alters retinoic acid regulation of cell growth and epidermal growth factor receptor expression.","8402622","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","8405671",1993,"Retinoic acid stimulates mouse lung development by a mechanism involving epithelial-mesenchymal interaction and regulation of epidermal growth factor receptors.","8405671","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","8180134",1994,"Retinoic acid differentially affects platelet-derived growth factor and epidermal growth factor-regulated cell growth of mouse osteoblast-like cells.","8180134","Tretinoin","Receptor, Epidermal Growth Factor"]
["Tretinoin","Receptors, LDL",1,0,1,0,"LDLR","10781690",2000,"Partial restoration of all trans retinoic acid (ATRA) sensitivity by compactin in ATRA-resistant leukemic cells (ATRA-R HL-60).","10781690","Tretinoin","Receptors, LDL"]
["Tretinoin","Receptors, LDL",1,0,1,0,"LDLR","22687440",2012,"Synthesis of octadecylamine-retinoic acid conjugate for enhanced cytotoxic effects of 5-FU using LDL targeted nanostructured lipid carriers.","22687440","Tretinoin","Receptors, LDL"]
["Tretinoin","Receptors, LDL",1,0,1,0,"LDLR","9772301",1998,"Enhancement of all-trans-retinoic acid efficiency in granulocytic differentiation of HL-60 cells by incorporation into low density lipoprotein.","9772301","Tretinoin","Receptors, LDL"]
["Tretinoin","Matrix Metalloproteinase 1",1,0,1,0,"MMP1","15215172",2004,"All-trans-retinoic acid suppresses matrix metalloproteinase activity and increases collagen synthesis in diabetic human skin in organ culture.","15215172","Tretinoin","Matrix Metalloproteinase 1"]
["Tretinoin","Matrix Metalloproteinase 1",1,0,1,0,"MMP1","15075337",2004,"Interaction between the aryl hydrocarbon receptor and retinoic acid pathways increases matrix metalloproteinase-1 expression in keratinocytes.","15075337","Tretinoin","Matrix Metalloproteinase 1"]
["Tretinoin","Matrix Metalloproteinase 1",1,0,1,0,"MMP1","11748248",2001,"A regulatory cascade involving retinoic acid, Cbfa1, and matrix metalloproteinases is coupled to the development of a process of perichondrial invasion and osteogenic differentiation during bone formation.","11748248","Tretinoin","Matrix Metalloproteinase 1"]
["Tretinoin","Matrix Metalloproteinase 1",1,0,1,0,"MMP1","11780404",2001,"All-trans retinoic acid in pulmonary vascular structural remodeling in rats with pulmonary hypertension induced by monocrotaline.","11780404","Tretinoin","Matrix Metalloproteinase 1"]
["Tretinoin","Matrix Metalloproteinase 1",1,0,1,0,"MMP1","19246282",2009,"[Effects of all-trans retinioic acid and tazarotene on MMP-1 and TIMP-1 expression in cultured human fibroblasts after heat shock].","19246282","Tretinoin","Matrix Metalloproteinase 1"]
["Tretinoin","Matrix Metalloproteinase 1",1,0,1,0,"MMP1","11713105",2001,"Retinoic acid attenuates cytokine-driven fibroblast degradation of extracellular matrix in three-dimensional culture.","11713105","Tretinoin","Matrix Metalloproteinase 1"]
["Tretinoin","Matrix Metalloproteinase 1",1,0,1,0,"MMP1","10729768",1998,"Effects of all-trans-retinoic acid incorporated into low-density lipoprotein on invasive properties of multidrug-resistant MCF-7 spheroids.","10729768","Tretinoin","Matrix Metalloproteinase 1"]
["Tretinoin","Matrix Metalloproteinase 1",1,0,1,0,"MMP1","10866818",2000,"Mechanisms of induction of human tissue inhibitor of metalloproteinases-1 (TIMP-1) gene expression by all-trans retinoic acid in combination with basic fibroblast growth factor.","10866818","Tretinoin","Matrix Metalloproteinase 1"]
["Tretinoin","Matrix Metalloproteinase 1",1,0,1,0,"MMP1","14756522",2003,"Tretinoin reverses upregulation of matrix metalloproteinase-13 in human keloid-derived fibroblasts.","14756522","Tretinoin","Matrix Metalloproteinase 1"]
["Tretinoin","Matrix Metalloproteinase 1",1,0,1,0,"MMP1","10432008",1999,"Human breast cancer cells activate procollagenase-1 and invade type I collagen: invasion is inhibited by all-trans retinoic acid.","10432008","Tretinoin","Matrix Metalloproteinase 1"]
["Tretinoin","Matrix Metalloproteinase 1",1,0,1,0,"MMP1","10996843",2000,"Retinoic acid combines with interleukin-1 to promote the degradation of collagen from bovine nasal cartilage: matrix metalloproteinases-1 and -13 are involved in cartilage collagen breakdown.","10996843","Tretinoin","Matrix Metalloproteinase 1"]
["Tretinoin","Matrix Metalloproteinase 1",1,0,1,0,"MMP1","14767528",2004,"In vitro antitumor potential of 4-BPRE, a butyryl aminophenyl ester of retinoic acid: role of the butyryl group.","14767528","Tretinoin","Matrix Metalloproteinase 1"]
["Tretinoin","Matrix Metalloproteinase 1",1,0,1,0,"MMP1","9888461",1999,"Transcriptional repression of the human collagenase-1 (MMP-1) gene in MDA231 breast cancer cells by all-trans-retinoic acid requires distal regions of the promoter.","9888461","Tretinoin","Matrix Metalloproteinase 1"]
["Tretinoin","Matrix Metalloproteinase 1",1,0,1,0,"MMP1","9264555",1997,"Inhibition of cartilage degradation and changes in physical properties induced by IL-1beta and retinoic acid using matrix metalloproteinase inhibitors.","9264555","Tretinoin","Matrix Metalloproteinase 1"]
["Tretinoin","Matrix Metalloproteinase 1",1,0,1,0,"MMP1","9664142",1998,"In vitro modulation of human melanoma cell invasion and proliferation by all-trans-retinoic acid.","9664142","Tretinoin","Matrix Metalloproteinase 1"]
["Tretinoin","Matrix Metalloproteinase 1",1,0,1,0,"MMP1","9111003",1997,"Stromelysin-3 induction and interstitial collagenase repression by retinoic acid. Therapeutical implication of receptor-selective retinoids dissociating transactivation and AP-1-mediated transrepression.","9111003","Tretinoin","Matrix Metalloproteinase 1"]
["Tretinoin","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","10646501",2000,"Induction of matrix metalloproteinase MMP-9 (92-kDa gelatinase) by retinoic acid in human neuroblastoma SKNBE cells: relevance to neuronal differentiation.","10646501","Tretinoin","Matrix Metalloproteinase 9"]
["Tretinoin","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","12906928",2003,"Regulation of pancreatic stellate cell function in vitro: biological and molecular effects of all-trans retinoic acid.","12906928","Tretinoin","Matrix Metalloproteinase 9"]
["Tretinoin","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","22475041",2012,"The potential mechanism for the different expressions of gelatinases induced by all-trans retinoic acid in different cells.","22475041","Tretinoin","Matrix Metalloproteinase 9"]
["Tretinoin","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","12139725",2002,"Simultaneous induction of matrix metalloproteinase-9 and interleukin 8 by all-trans retinoic acid in human PL-21 and NB4 myeloid leukaemia cells.","12139725","Tretinoin","Matrix Metalloproteinase 9"]
["Tretinoin","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","12126561",2002,"[Prophylactic effect of retinoic acid on chronic obstructive pulmonary emphysema in rats].","12126561","Tretinoin","Matrix Metalloproteinase 9"]
["Tretinoin","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","11471571",2001,"All trans-retinoic acid selectively down-regulates matrix metalloproteinase-9 (MMP-9) and up-regulates tissue inhibitor of metalloproteinase-1 (TIMP-1) in human bronchoalveolar lavage cells.","11471571","Tretinoin","Matrix Metalloproteinase 9"]
["Tretinoin","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","12553043",2002,"Anti-metastatic activities of all-trans retinoic acid, indole-3-carbinol and (+)-catechin in Dunning rat invasive prostate adenocarcinoma cells.","12553043","Tretinoin","Matrix Metalloproteinase 9"]
["Tretinoin","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","12193473",2002,"All-trans-retinoic acid induces nuclear factor kappaB activation and matrix metalloproteinase-9 expression and enhances basement membrane invasivity of differentiation-resistant human SK-N-BE 9N neuroblastoma Cells.","12193473","Tretinoin","Matrix Metalloproteinase 9"]
["Tretinoin","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","10792961",2000,"All-trans-retinoic acid decreases vein graft intimal hyperplasia and matrix metalloproteinase activity in vivo.","10792961","Tretinoin","Matrix Metalloproteinase 9"]
["Tretinoin","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","11172606",2001,"Retinoic acid and extracellular matrix inhibition of matrix metalloproteinase 9 expression is mediated by the mitogen activated protein kinase pathway.","11172606","Tretinoin","Matrix Metalloproteinase 9"]
["Tretinoin","Matrix Metalloproteinase 9",1,0,1,1,"MMP9","11437413",2001,"Low-dose retinoic acid enhances in vitro invasiveness of human oral squamous-cell-carcinoma cell lines.","11437413","Tretinoin","Matrix Metalloproteinase 9"]
["Tretinoin","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","11713105",2001,"Retinoic acid attenuates cytokine-driven fibroblast degradation of extracellular matrix in three-dimensional culture.","11713105","Tretinoin","Matrix Metalloproteinase 9"]
["Tretinoin","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","10432008",1999,"Human breast cancer cells activate procollagenase-1 and invade type I collagen: invasion is inhibited by all-trans retinoic acid.","10432008","Tretinoin","Matrix Metalloproteinase 9"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L2052,L2052)","v":"Tretinoin"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M2052,M2052)","v":"Matrix Metalloproteinase 9"},1,0,1,0,"MMP9",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K2052,K2052)","v":"11841792"},2002,"Matrix and serine protease expression during leukemic cell differentiation induced by aclacinomycin and all-trans-retinoic acid.","11841792","Tretinoin","Matrix Metalloproteinase 9"]
["Tretinoin","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","10507760",1999,"Retinoic acid stimulates meningioma cell adhesion to the extracellular matrix and inhibits invasion.","10507760","Tretinoin","Matrix Metalloproteinase 9"]
["Tretinoin","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","24310731",2013,"Effects of all-trans retinoic acid, retinol, and ?-carotene on murine macrophage activity.","24310731","Tretinoin","Matrix Metalloproteinase 9"]
["Tretinoin","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","20421725",2010,"All-trans retinoic acid (ATRA) downregulates MMP-9 by modulating its regulatory molecules.","20421725","Tretinoin","Matrix Metalloproteinase 9"]
["Tretinoin","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","21907828",2011,"All-trans retinoic acid can regulate the expressions of gelatinases and apolipoprotein E in glomerulosclerosis rats.","21907828","Tretinoin","Matrix Metalloproteinase 9"]
["Tretinoin","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","18641199",2008,"Retinoic acid decreases adherence of murine myeloid dendritic cells and increases production of matrix metalloproteinase-9.","18641199","Tretinoin","Matrix Metalloproteinase 9"]
["Tretinoin","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","17164434",2007,"Retinoids induce MMP-9 expression through RARalpha during mammary gland remodeling.","17164434","Tretinoin","Matrix Metalloproteinase 9"]
["Tretinoin","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","15215172",2004,"All-trans-retinoic acid suppresses matrix metalloproteinase activity and increases collagen synthesis in diabetic human skin in organ culture.","15215172","Tretinoin","Matrix Metalloproteinase 9"]
["Tretinoin","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","17369494",2007,"Catalase potentiates retinoic acid-induced THP-1 monocyte differentiation into macrophage through inhibition of peroxisome proliferator-activated receptor gamma.","17369494","Tretinoin","Matrix Metalloproteinase 9"]
["Tretinoin","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","18571505",2008,"Inhibiting the platelet derived growth factor receptor increases signs of retinoic acid syndrome in myeloid differentiated HL-60 cells.","18571505","Tretinoin","Matrix Metalloproteinase 9"]
["Tretinoin","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","19099751",2008,"[Retinoic acid diminished the expression of lung tissue matrix metalloproteinase-2 and matrix metalloproteinase-9 in hyperoxia-exposed premature rats through regulating mitogen-activated protein kinases].","19099751","Tretinoin","Matrix Metalloproteinase 9"]
["Tretinoin","Matrix Metalloproteinase 9",1,0,1,1,"MMP9","17968574",2008,"Inhibition of retinoic acid-induced skin irritation in calorie-restricted mice.","17968574","Tretinoin","Matrix Metalloproteinase 9"]
["Tretinoin","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","22000442",2011,"[Effects of all-trans retinoic acid on airway responsiveness and airway remodeling in rats with asthma].","22000442","Tretinoin","Matrix Metalloproteinase 9"]
["Tretinoin","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","21273387",2011,"All-trans retinoic acid results in irregular repair of septa and fails to inhibit proinflammatory macrophages.","21273387","Tretinoin","Matrix Metalloproteinase 9"]
["Tretinoin","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","14605041",2003,"All-trans retinoic acid modulates the balance of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in patients with emphysema.","14605041","Tretinoin","Matrix Metalloproteinase 9"]
["Tretinoin","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","19288012",2009,"Enhanced effects of PPARgamma ligands and RXR selective retinoids in combination to inhibit migration and invasiveness in cancer cells.","19288012","Tretinoin","Matrix Metalloproteinase 9"]
["Tretinoin","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","16914095",2006,"Comparative effects of interferon-gamma and all- trans retinoic acid on secreted and surface-associated matrix metalloproteinase-9 expression of human monocytes.","16914095","Tretinoin","Matrix Metalloproteinase 9"]
["Tretinoin","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","19357873",2009,"Effect of all-trans retinoic acid on renal expressions of matrix metalloproteinase-2, matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in rats with glomerulosclerosis.","19357873","Tretinoin","Matrix Metalloproteinase 9"]
["Tretinoin","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","17786368",2007,"Inhibitory effects of retinoic acid and IIF on growth, migration and invasiveness in the U87MG human glioblastoma cell line.","17786368","Tretinoin","Matrix Metalloproteinase 9"]
["Tretinoin","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","9407317",1998,"Retinoic acid treatment elevates matrix metalloproteinase-2 protein and mRNA levels in avian growth plate chondrocyte cultures.","9407317","Tretinoin","Matrix Metalloproteinase 9"]
["Tretinoin","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","9664142",1998,"In vitro modulation of human melanoma cell invasion and proliferation by all-trans-retinoic acid.","9664142","Tretinoin","Matrix Metalloproteinase 9"]
["Tretinoin","Matrix Metalloproteinase 9",1,0,1,0,"MMP9","9693177",1998,"Differential regulation of MMP-2 and MMP-9 gelatinases in cultured human keratinocytes.","9693177","Tretinoin","Matrix Metalloproteinase 9"]
["Tretinoin","NF-E2-Related Factor 2",1,0,1,0,"NFE2L2","25003661",2014,"Retinoic acid synergizes ATO-mediated cytotoxicity by precluding Nrf2 activity in AML cells.","25003661","Tretinoin","NF-E2-Related Factor 2"]
["Tretinoin","NF-E2-Related Factor 2",1,0,1,0,"NFE2L2","18845239",2008,"NRF2 as a determinant of cellular resistance in retinoic acid cytotoxicity.","18845239","Tretinoin","NF-E2-Related Factor 2"]
["Tretinoin","Receptors, Urokinase Plasminogen Activator",1,0,1,0,"PLAUR","17278423",2006,"[The fibrinolytic activity in leukemic cell lines and its alteration on all-trans retinoic acid treatment].","17278423","Tretinoin","Receptors, Urokinase Plasminogen Activator"]
["Tretinoin","Receptors, Urokinase Plasminogen Activator",1,0,1,0,"PLAUR","11348470",2001,"Retinoic acid upregulates the plasminogen activator system in human epidermal keratinocytes.","11348470","Tretinoin","Receptors, Urokinase Plasminogen Activator"]
["Tretinoin","Receptors, Urokinase Plasminogen Activator",1,0,1,0,"PLAUR","8404615",1993,"Retinoic acid potentiates phorbol ester-mediated induction of urokinase and plasminogen activator inhibitor type 2 in human myeloid leukemic cell lines.","8404615","Tretinoin","Receptors, Urokinase Plasminogen Activator"]
["Tretinoin","Receptors, Urokinase Plasminogen Activator",1,0,1,0,"PLAUR","8385052",1993,"Bovine urokinase-type plasminogen activator and its receptor: cloning and induction by retinoic acid.","8385052","Tretinoin","Receptors, Urokinase Plasminogen Activator"]
["Tretinoin","Receptors, Urokinase Plasminogen Activator",1,0,1,0,"PLAUR","9519778",1998,"Interferons and retinoids enhance and dexamethasone suppresses urokinase-mediated plasminogen activation in promyelocytic leukemia cells.","9519778","Tretinoin","Receptors, Urokinase Plasminogen Activator"]
["Tretinoin","Serum Amyloid A Protein",1,0,1,0,"SAA1","15259233",2004,"All-trans retinoic acid is increased in the acute phase-related hyporetinemia during Escherichia coli mastitis.","15259233","Tretinoin","Serum Amyloid A Protein"]
["Tretinoin","E-Selectin",1,0,1,0,"SELE","17498488",2007,"[Tripterine inhibits all-trans retinoic acid-caused adhesion between leukemia cells and endothelial cells].","17498488","Tretinoin","E-Selectin"]
["Tretinoin","E-Selectin",1,0,1,0,"SELE","14988223",2004,"Ionizing radiation-induced E-selectin gene expression and tumor cell adhesion is inhibited by lovastatin and all-trans retinoic acid.","14988223","Tretinoin","E-Selectin"]
["Tretinoin","E-Selectin",1,0,1,0,"SELE","8985093",1997,"Effect of all trans-retinoic acid (ATRA) on the adhesive and motility properties of acute promyelocytic leukemia cells.","8985093","Tretinoin","E-Selectin"]
["Tretinoin","E-Selectin",1,0,1,0,"SELE","8639429",1996,"All-trans-retinoic acid increases adhesion to endothelium of the human promyelocytic leukaemia cell line NB4.","8639429","Tretinoin","E-Selectin"]
["Tretinoin","E-Selectin",1,0,1,0,"SELE","7518108",1994,"Retinoic acid inhibits expression of E-selectin in endothelial cells and prolongs discordant xenograft survival.","7518108","Tretinoin","E-Selectin"]
["Tretinoin","E-Selectin",1,0,1,1,"SELE","7544967",1995,"Two concentrations of topical tretinoin (retinoic acid) cause similar improvement of photoaging but different degrees of irritation. A double-blind, vehicle-controlled comparison of 0.1% and 0.025% tretinoin creams.","7544967","Tretinoin","E-Selectin"]
["Tretinoin","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","1309036",1992,"Enhancement of tissue-type plasminogen activator levels by retinoids in rat tissues in vivo.","1309036","Tretinoin","Plasminogen Activator Inhibitor 1"]
["Tretinoin","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","11399257",2001,"Combined effect of retinoic acid and basic FGF on PAI-1 gene expression in vascular smooth muscle cells.","11399257","Tretinoin","Plasminogen Activator Inhibitor 1"]
["Tretinoin","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","12935977",2003,"All-trans retinoic acid modulates microvascular endothelial cell hemostatic properties.","12935977","Tretinoin","Plasminogen Activator Inhibitor 1"]
["Tretinoin","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","11348470",2001,"Retinoic acid upregulates the plasminogen activator system in human epidermal keratinocytes.","11348470","Tretinoin","Plasminogen Activator Inhibitor 1"]
["Tretinoin","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","11883720",2002,"Enhanced secretion of tissue plasminogen activator by simultaneous use of retinoic acid and ascorbic acid from tissue cultured gastroepiploic artery.","11883720","Tretinoin","Plasminogen Activator Inhibitor 1"]
["Tretinoin","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","11904524",2002,"Retinoids induce the PAI-1 gene expression through tyrosine kinase-dependent pathways in vascular smooth muscle cells.","11904524","Tretinoin","Plasminogen Activator Inhibitor 1"]
["Tretinoin","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","21206504",2011,"Amelioration of glomerulosclerosis with all-trans retinoic acid is linked to decreased plasminogen activator inhibitor-1 and ?-smooth muscle actin.","21206504","Tretinoin","Plasminogen Activator Inhibitor 1"]
["Tretinoin","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","18718172",2008,"All-trans retinoic acid inhibits the increases in fibronectin and PAI-1 induced by TGF-beta1 and Ang II in rat mesangial cells.","18718172","Tretinoin","Plasminogen Activator Inhibitor 1"]
["Tretinoin","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","23992207",2013,"An in vitro model for the pro-fibrotic effects of retinoids: mechanisms of action.","23992207","Tretinoin","Plasminogen Activator Inhibitor 1"]
["Tretinoin","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","15304040",2004,"Effects of all-trans retinoic acid or chemotherapy on the molecular regulation of systemic blood coagulation and fibrinolysis in patients with acute promyelocytic leukemia.","15304040","Tretinoin","Plasminogen Activator Inhibitor 1"]
["Tretinoin","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","16192631",2005,"Hepatocyte growth factor receptor signaling mediates the anti-fibrotic action of 9-cis-retinoic acid in glomerular mesangial cells.","16192631","Tretinoin","Plasminogen Activator Inhibitor 1"]
["Tretinoin","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","8497851",1993,"Retinoic acid enhances fibrinolytic activity in-vivo by enhancing tissue type plasminogen activator (t-PA) activity and inhibits venous thrombosis.","8497851","Tretinoin","Plasminogen Activator Inhibitor 1"]
["Tretinoin","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","7683888",1993,"Regulation of synthesis of some proteinase inhibitors in human hepatoma cells HepG2 by cytokines, hepatocyte growth factor and retinoic acid.","7683888","Tretinoin","Plasminogen Activator Inhibitor 1"]
["Tretinoin","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","9003003",1997,"Role of insulin-like growth factor binding protein-2 and its limited proteolysis in neuroblastoma cell proliferation: modulation by transforming growth factor-beta and retinoic acid.","9003003","Tretinoin","Plasminogen Activator Inhibitor 1"]
["Tretinoin","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","9519778",1998,"Interferons and retinoids enhance and dexamethasone suppresses urokinase-mediated plasminogen activation in promyelocytic leukemia cells.","9519778","Tretinoin","Plasminogen Activator Inhibitor 1"]
["Tretinoin","Plasminogen Activator Inhibitor 1",1,0,1,0,"SERPINE1","9398056",1997,"Retinoic acid-enhanced invasion through reconstituted basement membrane by human SK-N-SH neuroblastoma cells involves membrane-associated tissue-type plasminogen activator.","9398056","Tretinoin","Plasminogen Activator Inhibitor 1"]
["Tretinoin","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","23992207",2013,"An in vitro model for the pro-fibrotic effects of retinoids: mechanisms of action.","23992207","Tretinoin","Transforming Growth Factor beta1"]
["Tretinoin","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","12393416",2003,"Levels of phospho-Smad2/3 are sensors of the interplay between effects of TGF-beta and retinoic acid on monocytic and granulocytic differentiation of HL-60 cells.","12393416","Tretinoin","Transforming Growth Factor beta1"]
["Tretinoin","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","11676881",2001,"[Evidence for retinoic acid modulating expression of cyclin-dependent kinase inhibitors in rat hepatic stellate cells].","11676881","Tretinoin","Transforming Growth Factor beta1"]
["Tretinoin","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","21352343",2011,"Retinoic acids exhibit anti-fibrotic activity through the inhibition of 5-lipoxygenase expression in scleroderma fibroblasts.","21352343","Tretinoin","Transforming Growth Factor beta1"]
["Tretinoin","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","18846337",2008,"Effect of all-trans retinoic acid on liver fibrosis induced by common bile duct ligation in rats.","18846337","Tretinoin","Transforming Growth Factor beta1"]
["Tretinoin","Transforming Growth Factor beta1",1,0,1,1,"TGFB1","11029503",2000,"Biological activity of all-trans-retinoic acid with and without tamoxifen and alpha-interferon 2a in breast cancer patients.","11029503","Tretinoin","Transforming Growth Factor beta1"]
["Tretinoin","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","15389595",2005,"Regulation of proliferation and migration in retinoic acid treated C3H10T1/2 cells by TGF-beta isoforms.","15389595","Tretinoin","Transforming Growth Factor beta1"]
["Tretinoin","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","15777839",2005,"Modulation of hepatocyte growth factor induction in human skin fibroblasts by retinoic acid.","15777839","Tretinoin","Transforming Growth Factor beta1"]
["Tretinoin","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","20142360",2010,"Requirement for Runx proteins in IgA class switching acting downstream of TGF-beta 1 and retinoic acid signaling.","20142360","Tretinoin","Transforming Growth Factor beta1"]
["Tretinoin","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","11831438",2001,"Effects of all-trans-retinoic acid (atRA) on inducible nitric oxide synthase (iNOS) activity and transforming growth factor beta-1 production in experimental anti-GBM antibody-mediated glomerulonephritis.","11831438","Tretinoin","Transforming Growth Factor beta1"]
["Tretinoin","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","20172853",2010,"All-trans-retinoic acid promotes trafficking of human concentrative nucleoside transporter-3 (hCNT3) to the plasma membrane by a TGF-beta1-mediated mechanism.","20172853","Tretinoin","Transforming Growth Factor beta1"]
["Tretinoin","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","18397230",2008,"All-trans-retinoic acid ameliorates carbon tetrachloride-induced liver fibrosis in mice through modulating cytokine production.","18397230","Tretinoin","Transforming Growth Factor beta1"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L2116,L2116)","v":"Tretinoin"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M2116,M2116)","v":"Transforming Growth Factor beta1"},1,0,1,0,"TGFB1",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K2116,K2116)","v":"16096774"},2005,"[Antiangiogenic and anti-immunosuppressive therapeutic strategies in human head and neck squamous cell carcinoma (HNSCC)].","16096774","Tretinoin","Transforming Growth Factor beta1"]
["Tretinoin","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","17620363",2007,"All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation.","17620363","Tretinoin","Transforming Growth Factor beta1"]
["Tretinoin","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","17634193",2007,"Inhibition of Tgf beta signaling by endogenous retinoic acid is essential for primary lung bud induction.","17634193","Tretinoin","Transforming Growth Factor beta1"]
["Tretinoin","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","24022014",2013,"The mucosal factors retinoic acid and TGF-?1 induce phenotypically and functionally distinct dendritic cell types.","24022014","Tretinoin","Transforming Growth Factor beta1"]
["Tretinoin","Transforming Growth Factor beta1",1,0,1,1,"TGFB1","15799023",2005,"Transforming growth factor-beta1 signaling participates in the physiological and pathological regulation of mouse inner ear development by all-trans retinoic acid.","15799023","Tretinoin","Transforming Growth Factor beta1"]
["Tretinoin","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","16242776",2006,"Transforming growth factor-beta1 inhibits all-trans retinoic acid-induced apoptosis.","16242776","Tretinoin","Transforming Growth Factor beta1"]
["Tretinoin","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","16252840",2005,"Increased smooth muscle actin expression from bone marrow stromal cells under retinoic acid treatment: an attempt for autologous blood vessel tissue engineering.","16252840","Tretinoin","Transforming Growth Factor beta1"]
["Tretinoin","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","19363708",2009,"Modification of TGF-beta1 signaling pathway during NB4 cells differentiation by all-trans retinoid acid induction.","19363708","Tretinoin","Transforming Growth Factor beta1"]
["Tretinoin","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","21907828",2011,"All-trans retinoic acid can regulate the expressions of gelatinases and apolipoprotein E in glomerulosclerosis rats.","21907828","Tretinoin","Transforming Growth Factor beta1"]
["Tretinoin","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","23359509",2013,"Hepatic stellate cells preferentially induce Foxp3+ regulatory T cells by production of retinoic acid.","23359509","Tretinoin","Transforming Growth Factor beta1"]
["Tretinoin","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","24042439",2013,"All-transretinoic acid ameliorates bleomycin-induced lung fibrosis by downregulating the TGF-?1/Smad3 signaling pathway in rats.","24042439","Tretinoin","Transforming Growth Factor beta1"]
["Tretinoin","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","22212184",2012,"Effect of all-trans retinoic acid on unilateral ureteral obstruction model.","22212184","Tretinoin","Transforming Growth Factor beta1"]
["Tretinoin","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","19443527",2009,"All-trans-retinoic acid inhibits tumour growth of malignant pleural mesothelioma in mice.","19443527","Tretinoin","Transforming Growth Factor beta1"]
["Tretinoin","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","24374174",2014,"Retinoic acid remodels extracellular matrix (ECM) of cultured human fetal palate mesenchymal cells (hFPMCs) through down-regulation of TGF-?/Smad signaling.","24374174","Tretinoin","Transforming Growth Factor beta1"]
["Tretinoin","Transforming Growth Factor beta1",1,0,1,1,"TGFB1","19269151",2010,"Vitamin A deficiency alters rat lung alveolar basement membrane: reversibility by retinoic acid.","19269151","Tretinoin","Transforming Growth Factor beta1"]
["Tretinoin","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","22344541",2012,"All-trans retinoic acid inhibits mesangial cell proliferation by up-regulating p21Waf1/Cip1 and p27Kip1 and down-regulating Skp2.","22344541","Tretinoin","Transforming Growth Factor beta1"]
["Tretinoin","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","23190197",2014,"Retinoic acid improves recovery after nephrectomy and decreases renal TGF-?1 expression. Gender-related effects.","23190197","Tretinoin","Transforming Growth Factor beta1"]
["Tretinoin","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","23176567",2013,"All-trans retinoic acid attenuates the renal interstitial fibrosis lesion in rats but not by transforming growth factor-?1/Smad3 signaling pathway.","23176567","Tretinoin","Transforming Growth Factor beta1"]
["Tretinoin","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","18798497",2008,"[Effects of all-trans retinoic acid on the expression of TGF-beta 1 and COL-I in rat model of peritoneal dialysis].","18798497","Tretinoin","Transforming Growth Factor beta1"]
["Tretinoin","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","17023731",2006,"All-trans-retinoic acid prevents radiation- or bleomycin-induced pulmonary fibrosis.","17023731","Tretinoin","Transforming Growth Factor beta1"]
["Tretinoin","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","15448735",2004,"Can transforming growth factor-beta1 and retinoids modify the activity of estradiol and antiestrogens in MCF-7 breast cancer cells?.","15448735","Tretinoin","Transforming Growth Factor beta1"]
["Tretinoin","Transforming Growth Factor beta1",1,0,1,1,"TGFB1","20110732",2010,"Kidneys of Alb/TGF-beta1 transgenic mice are deficient in retinoic acid and exogenous retinoic acid shows dose-dependent toxicity.","20110732","Tretinoin","Transforming Growth Factor beta1"]
["Tretinoin","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","23744644",2013,"Retinoic acid, acting as a highly specific IgA isotype switch factor, cooperates with TGF-?1 to enhance the overall IgA response.","23744644","Tretinoin","Transforming Growth Factor beta1"]
["Tretinoin","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","20664575",2011,"Complementary roles of retinoic acid and TGF-?1 in coordinated expression of mucosal integrins by T cells.","20664575","Tretinoin","Transforming Growth Factor beta1"]
["Tretinoin","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","18718172",2008,"All-trans retinoic acid inhibits the increases in fibronectin and PAI-1 induced by TGF-beta1 and Ang II in rat mesangial cells.","18718172","Tretinoin","Transforming Growth Factor beta1"]
["Tretinoin","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","18293192",2008,"Activation of TGF-beta1 through up-regulation of TSP-1 by retinoic acid in retinal pigment epithelial cells.","18293192","Tretinoin","Transforming Growth Factor beta1"]
["Tretinoin","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","18243243",2008,"All-trans-retinoic acid attenuates radiation-induced intestinal fibrosis in mice.","18243243","Tretinoin","Transforming Growth Factor beta1"]
["Tretinoin","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","17785809",2007,"Vitamin A metabolites induce gut-homing FoxP3+ regulatory T cells.","17785809","Tretinoin","Transforming Growth Factor beta1"]
["Tretinoin","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","16539842",2006,"All-trans retinoic acid inhibited angiotensin II-induced increase in cell growth and collagen secretion of neonatal cardiac fibroblasts.","16539842","Tretinoin","Transforming Growth Factor beta1"]
["Tretinoin","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","15175265",2004,"Signaling hierarchy downstream of retinoic acid that independently regulates vascular remodeling and endothelial cell proliferation.","15175265","Tretinoin","Transforming Growth Factor beta1"]
["Tretinoin","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","21152098",2010,"Identification of retinoic acid in a high content screen for agents that overcome the anti-myogenic effect of TGF-beta-1.","21152098","Tretinoin","Transforming Growth Factor beta1"]
["Tretinoin","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","16192631",2005,"Hepatocyte growth factor receptor signaling mediates the anti-fibrotic action of 9-cis-retinoic acid in glomerular mesangial cells.","16192631","Tretinoin","Transforming Growth Factor beta1"]
["Tretinoin","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","24223992",2013,"Retinoic acid improves morphology of cultured peritoneal mesothelial cells from patients undergoing dialysis.","24223992","Tretinoin","Transforming Growth Factor beta1"]
["Tretinoin","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","23898044",2013,"All-trans retinoic acid and rapamycin synergize with transforming growth factor-?1 to induce regulatory T cells but confer different migratory capacities.","23898044","Tretinoin","Transforming Growth Factor beta1"]
["Tretinoin","Transforming Growth Factor beta1",1,0,1,0,"TGFB1","20197308",2010,"Proinsulin C-peptide antagonizes the profibrotic effects of TGF-beta1 via up-regulation of retinoic acid and HGF-related signaling pathways.","20197308","Tretinoin","Transforming Growth Factor beta1"]
["Tretinoin","Thrombomodulin",1,0,1,0,"THBD","10444171",1999,"Dexamethasone does not counteract the response of acute promyelocytic leukaemia cells to all-trans retinoic acid.","10444171","Tretinoin","Thrombomodulin"]
["Tretinoin","Thrombomodulin",1,0,1,0,"THBD","11036068",2001,"Acceleration of thrombomodulin gene transcription by retinoic acid: retinoic acid receptors and Sp1 regulate the promoter activity through interactions with two different sequences in the 5'-flanking region of human gene.","11036068","Tretinoin","Thrombomodulin"]
["Tretinoin","Thrombomodulin",1,0,1,0,"THBD","17493354",2007,"[Effects of arsenic trioxide or retinoic acid on mRNA and protein expression of tissue factor and thrombomodulin and procoagulant activity in NB4 cells].","17493354","Tretinoin","Thrombomodulin"]
["Tretinoin","Thrombomodulin",1,0,1,0,"THBD","1341059",1992,"Retinoic acid prevents cytokine-induced suppression of thrombomodulin expression on surface of human umbilical vascular endothelial cells in vitro.","1341059","Tretinoin","Thrombomodulin"]
["Tretinoin","Thrombomodulin",1,0,1,0,"THBD","12935977",2003,"All-trans retinoic acid modulates microvascular endothelial cell hemostatic properties.","12935977","Tretinoin","Thrombomodulin"]
["Tretinoin","Thrombomodulin",1,0,1,0,"THBD","22327096",2012,"Thrombomodulin enhances the antifibrinolytic and antileukemic effects of all-trans retinoic acid in acute promyelocytic leukemia cells.","22327096","Tretinoin","Thrombomodulin"]
["Tretinoin","Thrombomodulin",1,0,1,0,"THBD","16206674",2001,"[The impact of arsenic trioxide or all-trans retinoic acid treatment on coagulopathy in acute promyelocytic leukemia].","16206674","Tretinoin","Thrombomodulin"]
["Tretinoin","Thrombomodulin",1,0,1,0,"THBD","16713268",2006,"Thrombomodulin induction in cultured human endothelial cells by 9-cis-locked retinoic acid analogues.","16713268","Tretinoin","Thrombomodulin"]
["Tretinoin","Thrombomodulin",1,0,1,0,"THBD","8207015",1994,"Characterization of thrombomodulin expression in response to retinoic acid and identification of a retinoic acid response element in the human thrombomodulin gene.","8207015","Tretinoin","Thrombomodulin"]
["Tretinoin","Thrombomodulin",1,0,1,0,"THBD","8822923",1996,"Regulation of thrombomodulin expression by all-trans retinoic acid and tumor necrosis factor-alpha: differential responses in keratinocytes and endothelial cells.","8822923","Tretinoin","Thrombomodulin"]
["Tretinoin","Thrombomodulin",1,0,1,0,"THBD","9701452",1998,"Treatment of disseminated intravascular coagulation (DIC) with all-trans retinoic acid in an endotoxin-induced rat model.","9701452","Tretinoin","Thrombomodulin"]
["Tretinoin","Thrombomodulin",1,0,1,0,"THBD","7878635",1994,"Thrombomodulin induction by all-trans retinoic acid is independent of HL-60 cells differentiation to neutrophilic cells.","7878635","Tretinoin","Thrombomodulin"]
["Tretinoin","Thrombomodulin",1,0,1,0,"THBD","8555488",1996,"Anticoagulant effects of retinoic acids on leukemia cells.","8555488","Tretinoin","Thrombomodulin"]
["Tretinoin","Thrombomodulin",1,0,1,0,"THBD","8918245",1996,"A retinoic acid/cAMP-responsive enhancer containing a cAMP responsive element is required for the activation of the mouse thrombomodulin-encoding gene in differentiating F9 cells.","8918245","Tretinoin","Thrombomodulin"]
["Tretinoin","Thrombomodulin",1,0,1,0,"THBD","7949172",1994,"All-trans retinoic acid upregulates thrombomodulin and downregulates tissue-factor expression in acute promyelocytic leukemia cells: distinct expression of thrombomodulin and tissue factor in human leukemic cells.","7949172","Tretinoin","Thrombomodulin"]
["Tretinoin","Thrombomodulin",1,0,1,0,"THBD","9128763",1997,"Thrombomodulin, a functional surface protein on human keratinocytes, is regulated by retinoic acid.","9128763","Tretinoin","Thrombomodulin"]
["Tretinoin","Thrombomodulin",1,0,1,0,"THBD","9134635",1997,"Long-term follow-up of hemostatic molecular markers during remission induction therapy with all-trans retinoic acid for acute promyelocytic leukemia. Keio Hematology-Oncology Cooperative Study Group (KHOCS).","9134635","Tretinoin","Thrombomodulin"]
["Tretinoin","Tissue Inhibitor of Metalloproteinase-1",1,0,1,0,"TIMP1","10415756",1999,"Induction of human tissue inhibitor of metalloproteinase-1 gene expression by all-trans retinoic acid in combination with basic fibroblast growth factor involves both p42/44 and p38 MAP kinases.","10415756","Tretinoin","Tissue Inhibitor of Metalloproteinase-1"]
["Tretinoin","Tissue Inhibitor of Metalloproteinase-1",1,0,1,0,"TIMP1","11471571",2001,"All trans-retinoic acid selectively down-regulates matrix metalloproteinase-9 (MMP-9) and up-regulates tissue inhibitor of metalloproteinase-1 (TIMP-1) in human bronchoalveolar lavage cells.","11471571","Tretinoin","Tissue Inhibitor of Metalloproteinase-1"]
["Tretinoin","Tissue Inhibitor of Metalloproteinase-1",1,0,1,0,"TIMP1","10866818",2000,"Mechanisms of induction of human tissue inhibitor of metalloproteinases-1 (TIMP-1) gene expression by all-trans retinoic acid in combination with basic fibroblast growth factor.","10866818","Tretinoin","Tissue Inhibitor of Metalloproteinase-1"]
["Tretinoin","Tissue Inhibitor of Metalloproteinase-1",1,0,1,0,"TIMP1","20421725",2010,"All-trans retinoic acid (ATRA) downregulates MMP-9 by modulating its regulatory molecules.","20421725","Tretinoin","Tissue Inhibitor of Metalloproteinase-1"]
["Tretinoin","Tissue Inhibitor of Metalloproteinase-1",1,0,1,0,"TIMP1","18563181",2008,"All-trans retinoic acid shifts Propionibacterium acnes-induced matrix degradation expression profile toward matrix preservation in human monocytes.","18563181","Tretinoin","Tissue Inhibitor of Metalloproteinase-1"]
["Tretinoin","Tissue Inhibitor of Metalloproteinase-1",1,0,1,0,"TIMP1","18846337",2008,"Effect of all-trans retinoic acid on liver fibrosis induced by common bile duct ligation in rats.","18846337","Tretinoin","Tissue Inhibitor of Metalloproteinase-1"]
["Tretinoin","Tissue Inhibitor of Metalloproteinase-1",1,0,1,0,"TIMP1","19246282",2009,"[Effects of all-trans retinioic acid and tazarotene on MMP-1 and TIMP-1 expression in cultured human fibroblasts after heat shock].","19246282","Tretinoin","Tissue Inhibitor of Metalloproteinase-1"]
["Tretinoin","Tissue Inhibitor of Metalloproteinase-1",1,0,1,0,"TIMP1","21273387",2011,"All-trans retinoic acid results in irregular repair of septa and fails to inhibit proinflammatory macrophages.","21273387","Tretinoin","Tissue Inhibitor of Metalloproteinase-1"]
["Tretinoin","Tissue Inhibitor of Metalloproteinase-1",1,0,1,0,"TIMP1","10996843",2000,"Retinoic acid combines with interleukin-1 to promote the degradation of collagen from bovine nasal cartilage: matrix metalloproteinases-1 and -13 are involved in cartilage collagen breakdown.","10996843","Tretinoin","Tissue Inhibitor of Metalloproteinase-1"]
["Tretinoin","Tissue Inhibitor of Metalloproteinase-1",1,0,1,0,"TIMP1","14605041",2003,"All-trans retinoic acid modulates the balance of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in patients with emphysema.","14605041","Tretinoin","Tissue Inhibitor of Metalloproteinase-1"]
["Tretinoin","Tissue Inhibitor of Metalloproteinase-1",1,0,1,0,"TIMP1","19357873",2009,"Effect of all-trans retinoic acid on renal expressions of matrix metalloproteinase-2, matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in rats with glomerulosclerosis.","19357873","Tretinoin","Tissue Inhibitor of Metalloproteinase-1"]
["Tretinoin","Tissue Inhibitor of Metalloproteinase-1",1,0,1,0,"TIMP1","11713105",2001,"Retinoic acid attenuates cytokine-driven fibroblast degradation of extracellular matrix in three-dimensional culture.","11713105","Tretinoin","Tissue Inhibitor of Metalloproteinase-1"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L2180,L2180)","v":"Tretinoin"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M2180,M2180)","v":"Tissue Inhibitor of Metalloproteinase-1"},1,0,1,0,"TIMP1",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K2180,K2180)","v":"15215172"},2004,"All-trans-retinoic acid suppresses matrix metalloproteinase activity and increases collagen synthesis in diabetic human skin in organ culture.","15215172","Tretinoin","Tissue Inhibitor of Metalloproteinase-1"]
["Tretinoin","Tissue Inhibitor of Metalloproteinase-1",1,0,1,0,"TIMP1","10792961",2000,"All-trans-retinoic acid decreases vein graft intimal hyperplasia and matrix metalloproteinase activity in vivo.","10792961","Tretinoin","Tissue Inhibitor of Metalloproteinase-1"]
["Tretinoin","Tissue Inhibitor of Metalloproteinase-1",1,0,1,1,"TIMP1","11437413",2001,"Low-dose retinoic acid enhances in vitro invasiveness of human oral squamous-cell-carcinoma cell lines.","11437413","Tretinoin","Tissue Inhibitor of Metalloproteinase-1"]
["Tretinoin","Tissue Inhibitor of Metalloproteinase-1",1,0,1,0,"TIMP1","9664142",1998,"In vitro modulation of human melanoma cell invasion and proliferation by all-trans-retinoic acid.","9664142","Tretinoin","Tissue Inhibitor of Metalloproteinase-1"]
["Tretinoin","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","17498488",2007,"[Tripterine inhibits all-trans retinoic acid-caused adhesion between leukemia cells and endothelial cells].","17498488","Tretinoin","Vascular Cell Adhesion Molecule-1"]
["Tretinoin","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","11139446",2000,"Human renal mesangial cells are a target for the anti-inflammatory action of 9-cis retinoic acid.","11139446","Tretinoin","Vascular Cell Adhesion Molecule-1"]
["Tretinoin","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","10840075",2000,"Mechanisms mediating the inhibitory effect of all-trans retinoic acid on primitive hematopoietic stem cells in human long-term bone marrow culture.","10840075","Tretinoin","Vascular Cell Adhesion Molecule-1"]
["Tretinoin","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","18355041",2008,"All-trans-retinoic acid induces integrin-independent B-cell adhesion to ADAM disintegrin domains.","18355041","Tretinoin","Vascular Cell Adhesion Molecule-1"]
["Tretinoin","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","16928318",2006,"[In vitro effect of all-trans retinoic acid on cell adhesion molecule expression and adhesion capacity of bone marrow stromal cells in patients received peripheral blood stem cell transplantation].","16928318","Tretinoin","Vascular Cell Adhesion Molecule-1"]
["Tretinoin","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","15830921",2005,"All-trans retinoic acid and glycated albumin reciprocally influence their effects in human mesangial cells.","15830921","Tretinoin","Vascular Cell Adhesion Molecule-1"]
["Tretinoin","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","12513708",2002,"[Effects of retinoic acid on adhesion molecules expression and adhesive function in murine bone marrow stromal cell].","12513708","Tretinoin","Vascular Cell Adhesion Molecule-1"]
["Tretinoin","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","9521860",1998,"TNF-alpha and 9-cis-retinoic acid synergistically induce ICAM-1 expression: evidence for interaction of retinoid receptors with NF-kappa B.","9521860","Tretinoin","Vascular Cell Adhesion Molecule-1"]
["Tretinoin","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","8639429",1996,"All-trans-retinoic acid increases adhesion to endothelium of the human promyelocytic leukaemia cell line NB4.","8639429","Tretinoin","Vascular Cell Adhesion Molecule-1"]
["Tretinoin","Vascular Cell Adhesion Molecule-1",1,0,1,0,"VCAM1","9022083",1997,"Retinoic acid inhibits the regulated expression of vascular cell adhesion molecule-1 by cultured dermal microvascular endothelial cells.","9022083","Tretinoin","Vascular Cell Adhesion Molecule-1"]
["triadimefon","Transforming Growth Factor beta1",1,1,1,1,"TGFB1","18976680",2009,"Molecular mechanism of teratogenic effects induced by the fungicide triadimefon: study of the expression of TGF-beta mRNA and TGF-beta and CRABPI proteins during rat in vitro development.","18976680","triadimefon","Transforming Growth Factor beta1"]
["triadimefon","Transforming Growth Factor beta1",1,0,1,1,"TGFB1","18976680",2009,"Molecular mechanism of teratogenic effects induced by the fungicide triadimefon: study of the expression of TGF-beta mRNA and TGF-beta and CRABPI proteins during rat in vitro development.","18976680","triadimefon","Transforming Growth Factor beta1"]
["Triamcinolone","Transforming Growth Factor beta1",0,0,1,0,"TGFB1","22399283",2012,"Modulation of inflammatory and profibrotic signaling in a rabbit model of acute phonotrauma using triamcinolone.","22399283","Triamcinolone","Transforming Growth Factor beta1"]
["Triamcinolone Acetonide","Chemokine CCL2",0,0,0,0,"CCL2","12934384",2003,"[Effect of triamcinolone acetonide on the proliferation and monocyte chemoattractant protein expression in rat glomerular mesangial cells].","12934384","Triamcinolone Acetonide","Chemokine CCL2"]
["Triamcinolone Acetonide","Chemokine CCL2",0,0,0,0,"CCL2","20456252",2012,"Chemokines in aqueous humour before and after intravitreal triamcinolone acetonide in eyes with macular oedema associated with branch retinal vein occlusion.","20456252","Triamcinolone Acetonide","Chemokine CCL2"]
["Triamcinolone Acetonide","Chemokine CCL2",0,0,0,0,"CCL2","23490191",2013,"Intraocular concentrations of cytokines and chemokines in rhegmatogenous retinal detachment and the effect of intravitreal triamcinolone acetonide.","23490191","Triamcinolone Acetonide","Chemokine CCL2"]
["Triamcinolone Acetonide","Chemokine CXCL10",0,0,0,0,"CXCL10","23490191",2013,"Intraocular concentrations of cytokines and chemokines in rhegmatogenous retinal detachment and the effect of intravitreal triamcinolone acetonide.","23490191","Triamcinolone Acetonide","Chemokine CXCL10"]
["Triamcinolone Acetonide","Receptor, Epidermal Growth Factor",0,0,0,0,"EGFR","2383597",1990,"Effect of glucocorticoid on epidermal growth factor receptor in human salivary gland adenocarcinoma cell line HSG.","2383597","Triamcinolone Acetonide","Receptor, Epidermal Growth Factor"]
["Triamcinolone Acetonide","Receptor, Epidermal Growth Factor",0,0,0,0,"EGFR","3010916",1986,"Interaction between epidermal growth factor and triamcinolone acetonide in mouse palatal mesenchymal cells in vitro.","3010916","Triamcinolone Acetonide","Receptor, Epidermal Growth Factor"]
["Triamcinolone Acetonide","Receptor, Epidermal Growth Factor",0,0,0,0,"EGFR","3015380",1986,"Effect of triamcinolone acetonide on the growth of NEL-M1 human melanoma cells cultured in the presence and absence of growth stimulatory agents.","3015380","Triamcinolone Acetonide","Receptor, Epidermal Growth Factor"]
["Triamcinolone Acetonide","Matrix Metalloproteinase 1",0,0,0,0,"MMP1","12123742",2002,"Effects of polysulfated glycosaminoglycan and triamcinolone acetonid on the production of proteinases and their inhibitors by IL-1alpha treated articular chondrocytes.","12123742","Triamcinolone Acetonide","Matrix Metalloproteinase 1"]
["Triamcinolone Acetonide","Matrix Metalloproteinase 9",0,0,0,0,"MMP9","16816341",2006,"Differential glucocorticoid effects on proliferation and invasion of human trophoblast cell lines.","16816341","Triamcinolone Acetonide","Matrix Metalloproteinase 9"]
["Triamcinolone Acetonide","Matrix Metalloproteinase 9",0,0,0,0,"MMP9","11954780",2002,"Inhibitory effects of triamcinolone acetonide on bFGF-induced migration and tube formation in choroidal microvascular endothelial cells.","11954780","Triamcinolone Acetonide","Matrix Metalloproteinase 9"]
["Triamcinolone Acetonide","Matrix Metalloproteinase 9",0,0,0,1,"MMP9","18552607",2008,"The relationship between plasma MMP-9 and TIMP-2 levels and intraocular pressure elevation in diabetic patients after intravitreal triamcinolone injection.","18552607","Triamcinolone Acetonide","Matrix Metalloproteinase 9"]
["Triamcinolone Acetonide","E-Selectin",0,0,0,0,"SELE","15663512",2005,"Subcutaneous administration of collagen-polyvinylpyrrolidone down regulates IL-1beta, TNF-alpha, TGF-beta1, ELAM-1 and VCAM-1 expression in scleroderma skin lesions.","15663512","Triamcinolone Acetonide","E-Selectin"]
["Triamcinolone Acetonide","E-Selectin",0,0,0,0,"SELE","19273790",2009,"Early effects of intravitreal triamcinolone acetonide on inflammation and proliferation in human choroidal neovascularization.","19273790","Triamcinolone Acetonide","E-Selectin"]
["Triamcinolone Acetonide","Plasminogen Activator Inhibitor 1",0,0,0,0,"SERPINE1","12123742",2002,"Effects of polysulfated glycosaminoglycan and triamcinolone acetonid on the production of proteinases and their inhibitors by IL-1alpha treated articular chondrocytes.","12123742","Triamcinolone Acetonide","Plasminogen Activator Inhibitor 1"]
["Triamcinolone Acetonide","Transforming Growth Factor beta1",0,0,0,0,"TGFB1","18611924",2008,"The use of corticosteroids to treat keloids: a review.","18611924","Triamcinolone Acetonide","Transforming Growth Factor beta1"]
["Triamcinolone Acetonide","Tissue Inhibitor of Metalloproteinase-1",0,0,0,0,"TIMP1","23278565",2013,"Influence of corticosteroids on interleukin-1?-stimulated equine chondrocyte gene expression.","23278565","Triamcinolone Acetonide","Tissue Inhibitor of Metalloproteinase-1"]
["Triamcinolone Acetonide","Tissue Inhibitor of Metalloproteinase-1",0,0,0,0,"TIMP1","12123742",2002,"Effects of polysulfated glycosaminoglycan and triamcinolone acetonid on the production of proteinases and their inhibitors by IL-1alpha treated articular chondrocytes.","12123742","Triamcinolone Acetonide","Tissue Inhibitor of Metalloproteinase-1"]
["Triamcinolone Acetonide","Vascular Cell Adhesion Molecule-1",0,0,0,0,"VCAM1","12403933",2002,"Effects of triamcinolone acetonide on adult human lung fibroblasts: decrease in proliferation, surface molecule expression and mediator release.","12403933","Triamcinolone Acetonide","Vascular Cell Adhesion Molecule-1"]
["Triamcinolone Acetonide","Vascular Cell Adhesion Molecule-1",0,0,0,0,"VCAM1","12202538",2002,"Modulation of permeability and adhesion molecule expression by human choroidal endothelial cells.","12202538","Triamcinolone Acetonide","Vascular Cell Adhesion Molecule-1"]
["Trichloroacetic Acid","Receptor, Epidermal Growth Factor",1,0,1,0,"EGFR","7608388",1995,"Disseminated eruptive nevocellular nevi.","7608388","Trichloroacetic Acid","Receptor, Epidermal Growth Factor"]
["Trichloroacetic Acid","Transforming Growth Factor beta1",1,0,1,1,"TGFB1","17724602",2007,"Induction of PDGF-B in TCA-treated epidermal keratinocytes.","17724602","Trichloroacetic Acid","Transforming Growth Factor beta1"]
["vinclozolin","Macrophage Colony-Stimulating Factor",1,0,1,1,"CSF1","15925024",2005,"Myelotoxicity in genistein-, nonylphenol-, methoxychlor-, vinclozolin- or ethinyl estradiol-exposed F1 generations of Sprague-Dawley rats following developmental and adult exposures.","15925024","vinclozolin","Macrophage Colony-Stimulating Factor"]
["vinclozolin","Transforming Growth Factor beta1",1,0,1,1,"TGFB1","18629315",2008,"Early-onset endocrine disruptor-induced prostatitis in the rat.","18629315","vinclozolin","Transforming Growth Factor beta1"]
["Zalcitabine","Chemokine CCL2",0,0,0,1,"CCL2","17761732",2007,"Characterization of rodent models of HIV-gp120 and anti-retroviral-associated neuropathic pain.","17761732","Zalcitabine","Chemokine CCL2"]
["Zidovudine","Macrophage Colony-Stimulating Factor",1,1,0,0,"CSF1","12079557",2002,"Inhibition of HIV replication and macrophage colony-stimulating factor production in human macrophages by antiretroviral agents.","12079557","Zidovudine","Macrophage Colony-Stimulating Factor"]
["Zidovudine","Macrophage Colony-Stimulating Factor",1,1,0,0,"CSF1","8083612",1994,"In vitro activity of inhibitors of late stages of the replication of HIV in chronically infected macrophages.","8083612","Zidovudine","Macrophage Colony-Stimulating Factor"]
["Zidovudine","Receptors, LDL",1,1,0,0,"LDLR","8988240",1996,"Selective endocytosis of fluorothymidine and azidothymidine coupled to LDL into HIV infected mononuclear cells.","8988240","Zidovudine","Receptors, LDL"]

{"sheet":"Overview_NR","index":2,"n_rows":96,"n_cols":16,"rows_kept":96,"cut":false,"hidden":false,"merged":[[1,4,1,14]]}
["NR Overview"]
[null,null,null,null,"Article Counts"]
[null,null,null,null,"constitutive androstane receptor","farnesoid X-activated receptor","Nuclear Receptor Subfamily 1, Group F, Member 2","Nuclear Receptor Subfamily 1, Group F, Member 3","Nuclear Receptor Subfamily 4, Group A, Member 2","PPAR alpha","PPAR gamma","pregnane X receptor","Receptors, Glucocorticoid","retinoic acid receptor alpha","retinoic acid receptor gamma"]
["MeSHName","M281","M63","Gene Score",{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & E3,E3)","v":"constitutive androstane receptor"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & F3,F3)","v":"farnesoid X-activated receptor"},"Nuclear Receptor Subfamily 1, Group F, Member 2","Nuclear Receptor Subfamily 1, Group F, Member 3","Nuclear Receptor Subfamily 4, Group A, Member 2","PPAR alpha","PPAR gamma","pregnane X receptor","Receptors, Glucocorticoid","retinoic acid receptor alpha","retinoic acid receptor gamma","LinkName"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P5,P5)","v":"Tretinoin"},1,0,1,4,2,1,1,7,8,44,2,26,397,111,"Tretinoin"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P6,P6)","v":"Permethrin"},0,0,0,0,0,0,0,4,0,0,1,0,0,0,"Permethrin"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P7,P7)","v":"Estradiol"},1,0,1,3,1,0,0,1,5,19,2,60,4,2,"Estradiol"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P8,P8)","v":"Methotrexate"},0,0,1,4,0,0,1,1,1,1,1,5,0,0,"Methotrexate"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P9,P9)","v":"Nicotine"},0,0,1,0,0,0,0,1,4,12,1,3,0,0,"Nicotine"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P10,P10)","v":"Atrazine"},1,1,1,0,0,0,0,1,0,0,0,2,0,0,"Atrazine"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P11,P11)","v":"Chlorpyrifos"},0,0,1,0,0,0,0,1,0,0,0,0,0,0,"Chlorpyrifos"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P12,P12)","v":"Methyl Parathion"},1,0,1,0,0,0,0,1,0,0,0,0,0,0,"Methyl Parathion"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P13,P13)","v":"Corticosterone"},0,0,1,0,1,0,0,0,1,2,1,416,1,0,"Corticosterone"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P14,P14)","v":"Mifepristone"},0,0,1,0,0,0,0,0,0,1,1,260,0,0,"Mifepristone"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P15,P15)","v":"Triamcinolone Acetonide"},0,0,0,0,0,0,0,0,0,0,0,83,0,0,"Triamcinolone Acetonide"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P16,P16)","v":"Spironolactone"},0,0,1,0,0,0,0,0,0,2,4,41,0,0,"Spironolactone"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P17,P17)","v":"Tamoxifen"},0,0,1,0,0,0,0,0,1,5,4,10,2,0,"Tamoxifen"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P18,P18)","v":"Phenytoin"},0,0,1,3,0,0,0,0,0,0,2,8,0,0,"Phenytoin"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P19,P19)","v":"Triamcinolone"},0,0,1,0,0,0,0,0,0,0,0,6,0,0,"Triamcinolone"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P20,P20)","v":"bisphenol A"},1,1,1,0,0,0,1,0,0,6,8,4,2,0,"bisphenol A"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P21,P21)","v":"Caffeine"},0,0,1,0,0,0,0,0,0,1,0,4,0,0,"Caffeine"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P22,P22)","v":"Isoproterenol"},0,0,1,0,0,0,0,0,5,3,0,4,0,0,"Isoproterenol"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P23,P23)","v":"Theophylline"},0,0,1,0,0,0,0,0,0,1,0,4,0,0,"Theophylline"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P24,P24)","v":"Chlorpromazine"},1,1,1,0,0,0,0,0,0,0,0,3,0,0,"Chlorpromazine"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P25,P25)","v":"Diethylstilbestrol"},1,1,1,0,0,0,0,0,0,2,1,3,0,0,"Diethylstilbestrol"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P26,P26)","v":"Mercuric Chloride"},1,0,1,0,0,0,0,0,0,0,0,3,0,0,"Mercuric Chloride"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P27,P27)","v":"Phenobarbital"},0,0,0,48,0,0,0,0,3,0,14,3,0,0,"Phenobarbital"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P28,P28)","v":"Dibutyl Phthalate"},1,0,1,1,0,0,0,0,4,1,1,2,0,0,"Dibutyl Phthalate"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P29,P29)","v":"Dimethylnitrosamine"},0,0,1,0,0,0,0,0,0,0,0,2,0,0,"Dimethylnitrosamine"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P30,P30)","v":"Fenofibrate"},0,0,1,0,0,0,0,0,189,30,0,2,0,0,"Fenofibrate"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P31,P31)","v":"Flutamide"},1,1,1,1,0,0,0,0,0,0,1,2,0,0,"Flutamide"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P32,P32)","v":"Genistein"},0,0,1,0,0,0,0,0,2,15,1,2,0,0,"Genistein"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P33,P33)","v":"Glutaral"},1,0,1,0,0,0,0,0,0,0,0,2,0,0,"Glutaral"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P34,P34)","v":"Lovastatin"},0,0,1,0,0,0,0,0,0,5,2,2,0,0,"Lovastatin"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P35,P35)","v":"Mirex"},0,0,1,0,0,0,0,0,0,0,0,2,0,0,"Mirex"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P36,P36)","v":"Quercetin"},0,0,1,1,0,0,0,0,4,19,1,2,0,0,"Quercetin"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P37,P37)","v":"tolyfluanid"},0,0,0,0,0,0,0,0,0,0,0,2,0,0,"tolyfluanid"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P38,P38)","v":"2,4-D amine"},1,0,0,0,0,0,0,0,0,0,0,1,0,0,"2,4-D amine"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P39,P39)","v":"2,4-Dichlorophenoxyacetic Acid"},1,0,1,0,0,0,0,0,0,0,0,1,0,0,"2,4-Dichlorophenoxyacetic Acid"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P40,P40)","v":"acetonitrile"},0,0,0,0,0,0,0,0,0,0,0,1,0,0,"acetonitrile"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P41,P41)","v":"bis(tri-n-butyltin)oxide"},0,0,0,0,0,0,0,0,0,0,0,1,0,0,"bis(tri-n-butyltin)oxide"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P42,P42)","v":"celecoxib"},0,0,1,0,0,0,0,0,0,8,0,1,1,0,"celecoxib"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P43,P43)","v":"DDT"},0,0,1,2,0,0,0,0,0,0,2,1,0,0,"DDT"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P44,P44)","v":"Ethinyl Estradiol"},1,0,1,1,1,0,0,0,1,0,0,1,0,0,"Ethinyl Estradiol"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P45,P45)","v":"etridiazol"},0,0,1,0,0,0,0,0,0,0,0,1,0,0,"etridiazol"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P46,P46)","v":"fipronil"},1,0,1,1,0,0,0,0,0,0,1,1,0,0,"fipronil"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P47,P47)","v":"glycolic acid"},0,0,0,0,0,0,0,0,0,0,0,1,0,0,"glycolic acid"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P48,P48)","v":"Methyl Methanesulfonate"},1,1,1,0,0,0,0,0,0,0,0,1,0,0,"Methyl Methanesulfonate"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P49,P49)","v":"Propanil"},1,0,1,0,0,0,0,0,0,0,0,1,0,0,"Propanil"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P50,P50)","v":"Sodium Fluoride"},1,0,0,0,0,0,0,0,0,0,0,1,0,0,"Sodium Fluoride"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P51,P51)","v":"Sulfasalazine"},1,0,1,0,0,0,0,0,0,2,0,1,0,0,"Sulfasalazine"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P52,P52)","v":"Tannins"},0,0,0,0,0,0,0,0,2,2,1,1,0,0,"Tannins"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P53,P53)","v":"tebufenozide"},1,0,1,0,0,0,0,0,0,0,0,1,0,0,"tebufenozide"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P54,P54)","v":"Thiram"},1,0,1,0,0,0,0,0,0,0,0,1,0,0,"Thiram"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P55,P55)","v":"vinclozolin"},1,0,1,0,0,0,0,0,0,0,0,1,0,0,"vinclozolin"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P56,P56)","v":"2,4-dinitrotoluene"},1,1,1,0,0,0,0,0,1,1,0,0,0,0,"2,4-dinitrotoluene"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P57,P57)","v":"4-Butyrolactone"},0,0,1,0,0,0,0,0,0,3,0,0,0,0,"4-Butyrolactone"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P58,P58)","v":"4-nonylphenol"},0,0,1,0,0,0,0,0,1,1,1,0,0,0,"4-nonylphenol"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P59,P59)","v":"Acetaminophen"},1,0,1,6,1,0,0,0,3,0,6,0,0,0,"Acetaminophen"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P60,P60)","v":"alachlor"},1,0,1,0,0,0,0,0,0,0,1,0,0,0,"alachlor"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P61,P61)","v":"Aspirin"},1,0,1,0,0,0,0,0,9,9,0,0,0,0,"Aspirin"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P62,P62)","v":"benzophenone"},1,0,1,0,0,0,0,0,0,1,1,0,0,0,"benzophenone"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P63,P63)","v":"Cacodylic Acid"},1,0,0,0,0,0,0,0,0,0,1,0,0,0,"Cacodylic Acid"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P64,P64)","v":"Carbamazepine"},0,0,1,0,0,0,0,0,0,1,4,0,0,0,"Carbamazepine"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P65,P65)","v":"citral"},1,0,1,0,0,0,0,0,1,1,0,0,1,0,"citral"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P66,P66)","v":"cyproconazole"},1,0,1,1,0,0,0,0,0,0,0,0,0,0,"cyproconazole"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P67,P67)","v":"decamethrin"},0,0,1,0,0,0,0,0,0,0,1,0,0,0,"decamethrin"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P68,P68)","v":"Dichlorodiphenyl Dichloroethylene"},1,1,1,2,0,0,0,0,0,0,3,0,0,0,"Dichlorodiphenyl Dichloroethylene"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P69,P69)","v":"Diclofenac"},0,0,1,0,0,0,0,0,0,4,0,0,0,0,"Diclofenac"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P70,P70)","v":"Diethylhexyl Phthalate"},1,0,1,8,0,0,0,0,34,16,10,0,0,0,"Diethylhexyl Phthalate"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P71,P71)","v":"diisobutyl phthalate"},1,1,0,0,0,0,0,0,1,1,0,0,0,0,"diisobutyl phthalate"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P72,P72)","v":"dodecylbenzenesulfonic acid"},0,0,1,0,0,0,0,0,0,1,0,0,0,0,"dodecylbenzenesulfonic acid"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P73,P73)","v":"Endosulfan"},1,0,1,1,0,0,0,0,0,0,1,0,0,0,"Endosulfan"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P74,P74)","v":"Ethanolamine"},0,0,1,0,0,0,0,0,0,1,0,0,0,0,"Ethanolamine"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P75,P75)","v":"ethofenprox"},0,0,1,1,0,0,0,0,0,0,0,0,0,0,"ethofenprox"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P76,P76)","v":"fenvalerate"},0,0,1,0,0,0,0,0,0,0,1,0,0,0,"fenvalerate"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P77,P77)","v":"Glycerol"},0,0,1,0,0,0,0,0,0,3,0,0,0,0,"Glycerol"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P78,P78)","v":"hydroquinone"},0,0,1,0,0,0,0,0,0,1,0,0,0,0,"hydroquinone"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P79,P79)","v":"Iodine"},0,0,0,0,0,0,0,0,1,7,0,0,0,0,"Iodine"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P80,P80)","v":"isoeugenol"},1,1,1,0,0,0,0,0,0,1,0,0,0,0,"isoeugenol"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P81,P81)","v":"limonene"},0,0,1,0,0,0,0,0,1,0,0,0,0,0,"limonene"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P82,P82)","v":"Methoxychlor"},0,0,1,0,0,0,0,0,0,0,1,0,0,0,"Methoxychlor"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P83,P83)","v":"naphthalene"},0,0,1,0,1,0,0,0,0,0,0,0,0,0,"naphthalene"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P84,P84)","v":"nonylphenol"},0,0,0,1,0,0,0,0,1,0,3,0,0,0,"nonylphenol"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P85,P85)","v":"o,p'-DDT"},0,0,1,1,0,0,0,0,0,0,2,0,0,0,"o,p'-DDT"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P86,P86)","v":"Paraquat"},1,0,0,0,0,0,0,0,0,1,0,0,0,0,"Paraquat"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P87,P87)","v":"perfluorooctane sulfonic acid"},0,0,1,3,0,0,0,0,16,2,5,0,0,0,"perfluorooctane sulfonic acid"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P88,P88)","v":"perfluorooctanoic acid"},1,0,1,5,2,0,0,0,32,5,7,0,0,0,"perfluorooctanoic acid"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P89,P89)","v":"Piperonyl Butoxide"},1,0,1,1,0,0,0,0,1,0,0,0,0,0,"Piperonyl Butoxide"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P90,P90)","v":"propiconazole"},0,0,1,1,0,0,0,0,0,0,0,0,0,0,"propiconazole"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P91,P91)","v":"tebuconazole"},0,0,1,1,0,0,0,0,0,0,0,0,0,0,"tebuconazole"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P92,P92)","v":"tetrabromobisphenol A"},0,0,1,0,0,0,0,0,2,3,0,0,0,0,"tetrabromobisphenol A"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P93,P93)","v":"Thiophanate"},0,0,1,0,0,0,0,0,1,0,0,0,0,0,"Thiophanate"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P94,P94)","v":"Triclosan"},0,0,1,1,0,0,0,0,1,0,2,0,0,0,"Triclosan"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P95,P95)","v":"triflumizol"},0,0,1,0,0,0,0,0,0,2,0,0,0,0,"triflumizol"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & P96,P96)","v":"Zidovudine"},1,1,0,0,0,0,0,0,0,1,0,0,0,0,"Zidovudine"]

{"sheet":"Detail_NR","index":3,"n_rows":2326,"n_cols":13,"rows_kept":2326,"cut":false,"hidden":false,"merged":[]}
["NR Detail",null,null,null,null,null,"Note: only articles in which the chemical is the main topic are selected."]
["MeSHName","GeneName","M281","M63","Gene Score","Tox","Symbol","PMID","Pub Yr","Title","LinkPMID","MeSHName","GeneName"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L3,L3)","v":"2,4-D amine"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M3,M3)","v":"Receptors, Glucocorticoid"},1,0,0,1,"NR3C1",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K3,K3)","v":"15762548"},2005,"Characterization of thymic atrophy and the mechanism of thymocyte depletion after in vivo exposure to a mixture of herbicides.","15762548","2,4-D amine","Receptors, Glucocorticoid"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L4,L4)","v":"2,4-Dichlorophenoxyacetic Acid"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M4,M4)","v":"Receptors, Glucocorticoid"},1,0,1,1,"NR3C1",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K4,K4)","v":"15762548"},2005,"Characterization of thymic atrophy and the mechanism of thymocyte depletion after in vivo exposure to a mixture of herbicides.","15762548","2,4-Dichlorophenoxyacetic Acid","Receptors, Glucocorticoid"]
["2,4-dinitrotoluene","PPAR alpha",1,1,1,1,"PPARA","16917068",2006,"Gene expression profiles in fathead minnow exposed to 2,4-DNT: correlation with toxicity in mammals.","16917068","2,4-dinitrotoluene","PPAR alpha"]
["2,4-dinitrotoluene","PPAR gamma",1,1,1,1,"PPARG","16917068",2006,"Gene expression profiles in fathead minnow exposed to 2,4-DNT: correlation with toxicity in mammals.","16917068","2,4-dinitrotoluene","PPAR gamma"]
["4-Butyrolactone","PPAR gamma",0,0,1,0,"PPARG","15301739",2004,"Effects of a fatty acid synthase inhibitor on adipocyte differentiation of mouse 3T3-L1 cells.","15301739","4-Butyrolactone","PPAR gamma"]
["4-Butyrolactone","PPAR gamma",0,0,1,0,"PPARG","22934537",2012,"Plakilactones from the marine sponge Plakinastrella mamillaris. Discovery of a new class of marine ligands of peroxisome proliferator-activated receptor ?.","22934537","4-Butyrolactone","PPAR gamma"]
["4-Butyrolactone","PPAR gamma",0,0,1,0,"PPARG","20074659",2010,"Pseudomonas signal molecule 3-oxo-C12-homoserine lactone interferes with binding of rosiglitazone to human PPARgamma.","20074659","4-Butyrolactone","PPAR gamma"]
["4-nonylphenol","pregnane X receptor",0,0,1,0,"NR1I2","16406821",2006,"The xenoestrogen 4-nonylphenol modulates hepatic gene expression of pregnane X receptor, aryl hydrocarbon receptor, CYP3A and CYP1A1 in juvenile Atlantic salmon (Salmo salar).","16406821","4-nonylphenol","pregnane X receptor"]
["4-nonylphenol","PPAR alpha",0,0,1,1,"PPARA","23866175",2013,"Effects of 4-nonylphenol on hepatic gene expression of peroxisome proliferator-activated receptors and cytochrome P450 isoforms (CYP1A1 and CYP3A4) in juvenile sole (Solea solea).","23866175","4-nonylphenol","PPAR alpha"]
["4-nonylphenol","PPAR gamma",0,0,1,1,"PPARG","22739433",2012,"The endocrine disruptor 4-nonylphenol promotes adipocyte differentiation and induces obesity in mice.","22739433","4-nonylphenol","PPAR gamma"]
["Acetaminophen","farnesoid X-activated receptor",1,0,1,1,"NR1H4","20573685",2010,"Activation of the farnesoid X receptor provides protection against acetaminophen-induced hepatic toxicity.","20573685","Acetaminophen","farnesoid X-activated receptor"]
["Acetaminophen","pregnane X receptor",1,0,1,1,"NR1I2","19460945",2009,"Rifampicin-activated human pregnane X receptor and CYP3A4 induction enhance acetaminophen-induced toxicity.","19460945","Acetaminophen","pregnane X receptor"]
["Acetaminophen","pregnane X receptor",1,0,1,1,"NR1I2","15456926",2004,"Enhanced acetaminophen toxicity by activation of the pregnane X receptor.","15456926","Acetaminophen","pregnane X receptor"]
["Acetaminophen","pregnane X receptor",1,0,1,1,"NR1I2","21433044",2011,"Polyinosinic-polycytidylic acid suppresses acetaminophen-induced hepatotoxicity independent of type I interferons and toll-like receptor 3.","21433044","Acetaminophen","pregnane X receptor"]
["Acetaminophen","pregnane X receptor",1,0,1,1,"NR1I2","21898498",2011,"Activation of liver X receptor increases acetaminophen clearance and prevents its toxicity in mice.","21898498","Acetaminophen","pregnane X receptor"]
["Acetaminophen","pregnane X receptor",1,0,1,1,"NR1I2","16141365",2005,"Role of the nuclear receptor pregnane X receptor in acetaminophen hepatotoxicity.","16141365","Acetaminophen","pregnane X receptor"]
["Acetaminophen","pregnane X receptor",1,0,1,1,"NR1I2","24104199",2014,"MicroRNA-561 promotes acetaminophen-induced hepatotoxicity in HepG2 cells and primary human hepatocytes through downregulation of the nuclear receptor corepressor dosage-sensitive sex-reversal adrenal hypoplasia congenital critical region on the X chromosome, gene 1 (DAX-1).","24104199","Acetaminophen","pregnane X receptor"]
["Acetaminophen","constitutive androstane receptor",1,0,1,1,"NR1I3","12376703",2002,"Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR.","12376703","Acetaminophen","constitutive androstane receptor"]
["Acetaminophen","constitutive androstane receptor",1,0,1,1,"NR1I3","12376675",2002,"Toxicology. Protecting liver from painkiller's lethal dose.","12376675","Acetaminophen","constitutive androstane receptor"]
["Acetaminophen","constitutive androstane receptor",1,0,1,0,"NR1I3","24019224",2013,"Acetaminophen modulates P-glycoprotein functional expression at the blood-brain barrier by a constitutive androstane receptor-dependent mechanism.","24019224","Acetaminophen","constitutive androstane receptor"]
["Acetaminophen","constitutive androstane receptor",1,0,1,1,"NR1I3","15764585",2005,"Characterization of activating signal cointegrator-2 as a novel transcriptional coactivator of the xenobiotic nuclear receptor constitutive androstane receptor.","15764585","Acetaminophen","constitutive androstane receptor"]
["Acetaminophen","constitutive androstane receptor",1,0,1,1,"NR1I3","24104199",2014,"MicroRNA-561 promotes acetaminophen-induced hepatotoxicity in HepG2 cells and primary human hepatocytes through downregulation of the nuclear receptor corepressor dosage-sensitive sex-reversal adrenal hypoplasia congenital critical region on the X chromosome, gene 1 (DAX-1).","24104199","Acetaminophen","constitutive androstane receptor"]
["Acetaminophen","constitutive androstane receptor",1,0,1,1,"NR1I3","16109766",2005,"Transcription coactivator peroxisome proliferator-activated receptor-binding protein/mediator 1 deficiency abrogates acetaminophen hepatotoxicity.","16109766","Acetaminophen","constitutive androstane receptor"]
["Acetaminophen","PPAR alpha",1,0,1,1,"PPARA","22318764",2012,"Peroxisome proliferator-activated receptor alpha induction of uncoupling protein 2 protects against acetaminophen-induced liver toxicity.","22318764","Acetaminophen","PPAR alpha"]
["Acetaminophen","PPAR alpha",1,0,1,1,"PPARA","19256530",2009,"Serum metabolomics reveals irreversible inhibition of fatty acid beta-oxidation through the suppression of PPARalpha activation as a contributing mechanism of acetaminophen-induced hepatotoxicity.","19256530","Acetaminophen","PPAR alpha"]
["Acetaminophen","PPAR alpha",1,0,1,1,"PPARA","18501395",2008,"Nonalcoholic steatohepatitic (NASH) mice are protected from higher hepatotoxicity of acetaminophen upon induction of PPARalpha with clofibrate.","18501395","Acetaminophen","PPAR alpha"]
["acetonitrile","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","1689882",1990,"Steroid receptor exchange assay in the presence of acetonitrile: application to the study of glucocorticoid- and anti-glucocorticoid-receptor complexes.","1689882","acetonitrile","Receptors, Glucocorticoid"]
["alachlor","pregnane X receptor",1,0,1,1,"NR1I2","17207564",2007,"Cytotoxicity of chloroacetanilide herbicide alachlor in HepG2 cells independent of CYP3A4 and CYP3A7.","17207564","alachlor","pregnane X receptor"]
["Aspirin","PPAR alpha",1,0,1,0,"PPARA","18971601",2009,"Aspirin inhibits MMP-2 and MMP-9 expressions and activities through upregulation of PPARalpha/gamma and TIMP gene expressions in ox-LDL-stimulated macrophages derived from human monocytes.","18971601","Aspirin","PPAR alpha"]
["Aspirin","PPAR alpha",1,0,1,0,"PPARA","18222077",2008,"Differential modulation of PPARalpha and gamma target gene expression in the liver and kidney of rats treated with aspirin.","18222077","Aspirin","PPAR alpha"]
["Aspirin","PPAR alpha",1,0,1,0,"PPARA","19880272",2010,"Aspirin inhibits MMP-9 mRNA expression and release via the PPARalpha/gamma and COX-2/mPGES-1-mediated pathways in macrophages derived from THP-1 cells.","19880272","Aspirin","PPAR alpha"]
["Aspirin","PPAR alpha",1,0,1,0,"PPARA","19462226",2009,"Aspirin inhibits MMP-2 and MMP-9 expression and activity through PPARalpha/gamma and TIMP-1-mediated mechanisms in cultured mouse celiac macrophages.","19462226","Aspirin","PPAR alpha"]
["Aspirin","PPAR alpha",1,0,1,0,"PPARA","16600694",2006,"Aspirin and PPAR-alpha activators inhibit monocyte chemoattractant protein-1 expression induced by high glucose concentration in human endothelial cells.","16600694","Aspirin","PPAR alpha"]
["Aspirin","PPAR alpha",1,0,1,0,"PPARA","21088444",2010,"Aspirin increases apolipoprotein-A-I-mediated cholesterol efflux via enhancing expression of ATP-binding cassette transporter A1.","21088444","Aspirin","PPAR alpha"]
["Aspirin","PPAR alpha",1,0,1,0,"PPARA","16816107",2006,"Aspirin regulates expression and function of scavenger receptor-BI in macrophages: studies in primary human macrophages and in mice.","16816107","Aspirin","PPAR alpha"]
["Aspirin","PPAR alpha",1,0,1,0,"PPARA","15646027",2004,"Aspirin-induced apoptosis in jurkat cells is not mediated by peroxisome proliferator-activated receptor delta.","15646027","Aspirin","PPAR alpha"]
["Aspirin","PPAR alpha",1,0,1,0,"PPARA","15769457",2005,"Aspirin increases CD36, SR-BI, and ABCA1 expression in human THP-1 macrophages.","15769457","Aspirin","PPAR alpha"]
["Aspirin","PPAR gamma",1,0,1,0,"PPARG","19880272",2010,"Aspirin inhibits MMP-9 mRNA expression and release via the PPARalpha/gamma and COX-2/mPGES-1-mediated pathways in macrophages derived from THP-1 cells.","19880272","Aspirin","PPAR gamma"]
["Aspirin","PPAR gamma",1,0,1,0,"PPARG","19462226",2009,"Aspirin inhibits MMP-2 and MMP-9 expression and activity through PPARalpha/gamma and TIMP-1-mediated mechanisms in cultured mouse celiac macrophages.","19462226","Aspirin","PPAR gamma"]
["Aspirin","PPAR gamma",1,0,1,0,"PPARG","16489531",2006,"PPARgamma and colon and rectal cancer: associations with specific tumor mutations, aspirin, ibuprofen and insulin-related genes (United States).","16489531","Aspirin","PPAR gamma"]
["Aspirin","PPAR gamma",1,0,1,0,"PPARG","19908241",2010,"The synergistic anticancer effect of troglitazone combined with aspirin causes cell cycle arrest and apoptosis in human lung cancer cells.","19908241","Aspirin","PPAR gamma"]
["Aspirin","PPAR gamma",1,0,1,0,"PPARG","15646027",2004,"Aspirin-induced apoptosis in jurkat cells is not mediated by peroxisome proliferator-activated receptor delta.","15646027","Aspirin","PPAR gamma"]
["Aspirin","PPAR gamma",1,0,1,0,"PPARG","18222077",2008,"Differential modulation of PPARalpha and gamma target gene expression in the liver and kidney of rats treated with aspirin.","18222077","Aspirin","PPAR gamma"]
["Aspirin","PPAR gamma",1,0,1,0,"PPARG","15769457",2005,"Aspirin increases CD36, SR-BI, and ABCA1 expression in human THP-1 macrophages.","15769457","Aspirin","PPAR gamma"]
["Aspirin","PPAR gamma",1,0,1,0,"PPARG","23085268",2012,"Effect of S-aspirin, a novel hydrogen-sulfide-releasing aspirin (ACS14), on atherosclerosis in apoE-deficient mice.","23085268","Aspirin","PPAR gamma"]
["Aspirin","PPAR gamma",1,0,1,0,"PPARG","18971601",2009,"Aspirin inhibits MMP-2 and MMP-9 expressions and activities through upregulation of PPARalpha/gamma and TIMP gene expressions in ox-LDL-stimulated macrophages derived from human monocytes.","18971601","Aspirin","PPAR gamma"]
["Atrazine","Receptors, Glucocorticoid",1,1,1,0,"NR3C1","17331471",2007,"Herbicide atrazine activates SF-1 by direct affinity and concomitant co-activators recruitments to induce aromatase expression via promoter II.","17331471","Atrazine","Receptors, Glucocorticoid"]
["Atrazine","Receptors, Glucocorticoid",1,1,1,1,"NR3C1","19836090",2010,"Atrazine affects kidney and adrenal hormones (AHs) related genes expressions of rare minnow (Gobiocypris rarus).","19836090","Atrazine","Receptors, Glucocorticoid"]
["Atrazine","Nuclear Receptor Subfamily 4, Group A, Member 2",1,1,1,1,"NR4A2","24561379",2014,"The long-term effects of the herbicide atrazine on the dopaminergic system following exposure during pubertal development.","24561379","Atrazine","Nuclear Receptor Subfamily 4, Group A, Member 2"]
["benzophenone","pregnane X receptor",1,0,1,1,"NR1I2","14613717",2003,"Endocrine disruptors induce cytochrome P450 by affecting transcriptional regulation via pregnane X receptor.","14613717","benzophenone","pregnane X receptor"]
["benzophenone","PPAR gamma",1,0,1,0,"PPARG","20734309",2010,"Structural basis for the improved potency of peroxisome proliferator-activated receptor (PPAR) agonists.","20734309","benzophenone","PPAR gamma"]
["bis(tri-n-butyltin)oxide","Receptors, Glucocorticoid",0,0,0,1,"NR3C1","17553608",2007,"In vitro immunotoxicity of bis(tri-n-butyltin)oxide (TBTO) studied by toxicogenomics.","17553608","bis(tri-n-butyltin)oxide","Receptors, Glucocorticoid"]
["bisphenol A","pregnane X receptor",1,1,1,0,"NR1I2","23714657",2013,"In vitro study on the agonistic and antagonistic activities of bisphenol-S and other bisphenol-A congeners and derivatives via nuclear receptors.","23714657","bisphenol A","pregnane X receptor"]
["bisphenol A","pregnane X receptor",1,1,1,1,"NR1I2","24755147",2014,"Bisphenol A increases atherosclerosis in pregnane X receptor-humanized ApoE deficient mice.","24755147","bisphenol A","pregnane X receptor"]
["bisphenol A","pregnane X receptor",1,1,1,1,"NR1I2","24388193",2014,"Nuclear receptor profiling of bisphenol-A and its halogenated analogues.","24388193","bisphenol A","pregnane X receptor"]
["bisphenol A","pregnane X receptor",1,1,1,0,"NR1I2","11581012",2001,"Bisphenol-A, an environmental estrogen, activates the human orphan nuclear receptor, steroid and xenobiotic receptor-mediated transcription.","11581012","bisphenol A","pregnane X receptor"]
["bisphenol A","pregnane X receptor",1,1,1,0,"NR1I2","10707959",2000,"Endocrine disrupting chemicals, phthalic acid and nonylphenol, activate Pregnane X receptor-mediated transcription.","10707959","bisphenol A","pregnane X receptor"]
["bisphenol A","pregnane X receptor",1,1,1,1,"NR1I2","23384967",2013,"Comparative analysis of human CYP3A4 and rat CYP3A1 induction and relevant gene expression by bisphenol A and diethylstilbestrol: implications for toxicity testing paradigms.","23384967","bisphenol A","pregnane X receptor"]
["bisphenol A","pregnane X receptor",1,1,1,0,"NR1I2","22214767",2012,"Bisphenol A and its analogues activate human pregnane X receptor.","22214767","bisphenol A","pregnane X receptor"]
["bisphenol A","pregnane X receptor",1,1,1,0,"NR1I2","22382401",2012,"BPA and PXR activation: human receptor is affected, mouse receptor is not.","22382401","bisphenol A","pregnane X receptor"]
["bisphenol A","Receptors, Glucocorticoid",1,1,1,1,"NR3C1","20669259",2010,"Bisphenol-A can bind to human glucocorticoid receptor as an agonist: an in silico study.","20669259","bisphenol A","Receptors, Glucocorticoid"]
["bisphenol A","Receptors, Glucocorticoid",1,1,1,0,"NR3C1","11137887",2001,"The environmental estrogenic compound bisphenol A exerts estrogenic effects on mouse hippocampal (HT-22) cells: neuroprotection against glutamate and amyloid beta protein toxicity.","11137887","bisphenol A","Receptors, Glucocorticoid"]
["bisphenol A","Receptors, Glucocorticoid",1,1,1,1,"NR3C1","21605673",2011,"Bisphenol A: an endocrine disruptor with widespread exposure and multiple effects.","21605673","bisphenol A","Receptors, Glucocorticoid"]
["bisphenol A","Receptors, Glucocorticoid",1,1,1,1,"NR3C1","24323913",2014,"Perinatal exposure to low-dose bisphenol A affects the neuroendocrine stress response in rats.","24323913","bisphenol A","Receptors, Glucocorticoid"]
["bisphenol A","PPAR gamma",1,1,1,1,"PPARG","24388193",2014,"Nuclear receptor profiling of bisphenol-A and its halogenated analogues.","24388193","bisphenol A","PPAR gamma"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L68,L68)","v":"bisphenol A"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M68,M68)","v":"PPAR gamma"},1,1,1,1,"PPARG",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K68,K68)","v":"20064783"},2010,"Peroxisome proliferator-activated receptor-gamma mediates bisphenol A inhibition of FSH-stimulated IGF-1, aromatase, and estradiol in human granulosa cells.","20064783","bisphenol A","PPAR gamma"]
["bisphenol A","PPAR gamma",1,1,1,0,"PPARG","23090578",2013,"The environmental obesogen bisphenol A promotes adipogenesis by increasing the amount of 11?-hydroxysteroid dehydrogenase type 1 in the adipose tissue of children.","23090578","bisphenol A","PPAR gamma"]
["bisphenol A","PPAR gamma",1,1,1,1,"PPARG","20019905",2009,"Perinatal exposure to bisphenol a alters early adipogenesis in the rat.","20019905","bisphenol A","PPAR gamma"]
["bisphenol A","PPAR gamma",1,1,1,0,"PPARG","22662114",2012,"Bisphenol A-mediated suppression of LPL gene expression inhibits triglyceride accumulation during adipogenic differentiation of human adult stem cells.","22662114","bisphenol A","PPAR gamma"]
["bisphenol A","PPAR gamma",1,1,1,0,"PPARG","21622942",2011,"Characterization of novel ligands of ER?, Er?, and PPAR?: the case of halogenated bisphenol A and their conjugated metabolites.","21622942","bisphenol A","PPAR gamma"]
["bisphenol A","retinoic acid receptor alpha",1,1,1,1,"RARA","15738621",2005,"Effects of in utero exposure to bisphenol A on mRNA expression of arylhydrocarbon and retinoid receptors in murine embryos.","15738621","bisphenol A","retinoic acid receptor alpha"]
["bisphenol A","retinoic acid receptor alpha",1,1,1,0,"RARA","14967906",2003,"Effects of in utero exposure to bisphenol A on expression of RARalpha and RXRalpha mRNAs in murine embryos.","14967906","bisphenol A","retinoic acid receptor alpha"]
["bisphenol A","Nuclear Receptor Subfamily 1, Group F, Member 3",1,1,1,0,"RORC","22659100",2012,"Highly potent binding and inverse agonist activity of bisphenol A derivatives for retinoid-related orphan nuclear receptor ROR?.","22659100","bisphenol A","Nuclear Receptor Subfamily 1, Group F, Member 3"]
["Cacodylic Acid","pregnane X receptor",1,0,0,1,"NR1I2","19084030",2009,"Arsenite and its metabolites, MMA(III) and DMA(III), modify CYP3A4, PXR and RXR alpha expression in the small intestine of CYP3A4 transgenic mice.","19084030","Cacodylic Acid","pregnane X receptor"]
["Caffeine","Receptors, Glucocorticoid",0,0,1,1,"NR3C1","22583948",2012,"Fetal rat metabonome alteration by prenatal caffeine ingestion probably due to the increased circulatory glucocorticoid level and altered peripheral glucose and lipid metabolic pathways.","22583948","Caffeine","Receptors, Glucocorticoid"]
["Caffeine","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","23272120",2012,"Synergistic effect of caffeine and glucocorticoids on expression of surfactant protein B (SP-B) mRNA.","23272120","Caffeine","Receptors, Glucocorticoid"]
["Caffeine","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","16212938",2005,"Caffeine-mediated enhancement of glucocorticoid receptor activity in human osteoblastic cells.","16212938","Caffeine","Receptors, Glucocorticoid"]
["Caffeine","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","23044054",2013,"Caffeine neuroprotects against dexamethasone-induced anxiety-like behaviour in the Zebrafish (Danio rerio).","23044054","Caffeine","Receptors, Glucocorticoid"]
["Caffeine","PPAR gamma",0,0,1,0,"PPARG","18486259",2008,"Pharmacological application of caffeine inhibits TGF-beta-stimulated connective tissue growth factor expression in hepatocytes via PPARgamma and SMAD2/3-dependent pathways.","18486259","Caffeine","PPAR gamma"]
["Carbamazepine","pregnane X receptor",0,0,1,0,"NR1I2","21996064",2012,"Histone deacetylase 1 is required for Carbamazepine-induced CYP3A4 expression.","21996064","Carbamazepine","pregnane X receptor"]
["Carbamazepine","pregnane X receptor",0,0,1,0,"NR1I2","24384557",2014,"Pregnane X receptor and hepatocyte nuclear factor 4? polymorphisms are cooperatively associated with carbamazepine autoinduction.","24384557","Carbamazepine","pregnane X receptor"]
["Carbamazepine","pregnane X receptor",0,0,1,0,"NR1I2","17112801",2006,"Transcriptional profiling of genes induced in the livers of patients treated with carbamazepine.","17112801","Carbamazepine","pregnane X receptor"]
["Carbamazepine","pregnane X receptor",0,0,1,0,"NR1I2","23252947",2013,"Association of carbamazepine major metabolism and transport pathway gene polymorphisms and pharmacokinetics in patients with epilepsy.","23252947","Carbamazepine","pregnane X receptor"]
["Carbamazepine","PPAR gamma",0,0,1,0,"PPARG","22889231",2013,"Carbamazepine directly inhibits adipocyte differentiation through activation of the ERK 1/2 pathway.","22889231","Carbamazepine","PPAR gamma"]
["celecoxib","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","15700047",2005,"Inhibition of COX-2 by celecoxib enhances glucocorticoid receptor function.","15700047","celecoxib","Receptors, Glucocorticoid"]
["celecoxib","PPAR gamma",0,0,1,0,"PPARG","20514536",2010,"The role of NF-?B and PPAR? in experimentally induced colorectal cancer and chemoprevention by cyclooxygenase-2 inhibitors.","20514536","celecoxib","PPAR gamma"]
["celecoxib","PPAR gamma",0,0,1,0,"PPARG","16536899",2006,"Anti-cancer effect of celecoxib and aerosolized docetaxel against human non-small cell lung cancer cell line, A549.","16536899","celecoxib","PPAR gamma"]
["celecoxib","PPAR gamma",0,0,1,0,"PPARG","18676768",2008,"Suppression of tumor formation by a cyclooxygenase-2 inhibitor and a peroxisome proliferator-activated receptor gamma agonist in an in vivo mouse model of spontaneous breast cancer.","18676768","celecoxib","PPAR gamma"]
["celecoxib","PPAR gamma",0,0,1,0,"PPARG","15629510",2005,"The selective cyclooxygenase-2 inhibitor celecoxib modulates the formation of vasoconstrictor eicosanoids and activates PPARgamma. Influence of albumin.","15629510","celecoxib","PPAR gamma"]
["celecoxib","PPAR gamma",0,0,1,0,"PPARG","21683949",2011,"The inhibitory effect of celecoxib and rosiglitazone on experimental endometriosis.","21683949","celecoxib","PPAR gamma"]
["celecoxib","PPAR gamma",0,0,1,0,"PPARG","23943857",2013,"Induction but not inhibition of COX-2 confers human lung cancer cell apoptosis by celecoxib.","23943857","celecoxib","PPAR gamma"]
["celecoxib","PPAR gamma",0,0,1,0,"PPARG","19522023",2009,"Anti-Helicobacter pylori therapy followed by celecoxib on progression of gastric precancerous lesions.","19522023","celecoxib","PPAR gamma"]
["celecoxib","PPAR gamma",0,0,1,0,"PPARG","21559762",2011,"Inhibitory effect of celecoxib in lung carcinoma by regulation of cyclooxygenase-2/cytosolic phospholipase A? and peroxisome proliferator-activated receptor gamma.","21559762","celecoxib","PPAR gamma"]
["celecoxib","retinoic acid receptor alpha",0,0,1,0,"RARA","17717820",2007,"[Celecoxib-induced apoptosis in acute promyelocytic leukemia cell line MR2 and its mechanism].","17717820","celecoxib","retinoic acid receptor alpha"]
["Chlorpromazine","Receptors, Glucocorticoid",1,1,1,0,"NR3C1","16581232",2007,"Effects of neurosteroids on glucocorticoid receptor-mediated gene transcription in LMCAT cells--a possible interaction with psychotropic drugs.","16581232","Chlorpromazine","Receptors, Glucocorticoid"]
["Chlorpromazine","Receptors, Glucocorticoid",1,1,1,0,"NR3C1","15589393",2004,"Effects of lipopolysaccharide and chlorpromazine on glucocorticoid receptor-mediated gene transcription and immunoreactivity: a possible involvement of p38-MAP kinase.","15589393","Chlorpromazine","Receptors, Glucocorticoid"]
["Chlorpromazine","Receptors, Glucocorticoid",1,1,1,0,"NR3C1","12423673",2002,"Chlorpromazine inhibits the glucocorticoid receptor-mediated gene transcription in a calcium-dependent manner.","12423673","Chlorpromazine","Receptors, Glucocorticoid"]
["Chlorpyrifos","Nuclear Receptor Subfamily 4, Group A, Member 2",0,0,1,1,"NR4A2","18977431",2009,"Repeated developmental exposure to chlorpyrifos and methyl parathion causes persistent alterations in nicotinic acetylcholine subunit mRNA expression with chlorpyrifos altering dopamine metabolite levels.","18977431","Chlorpyrifos","Nuclear Receptor Subfamily 4, Group A, Member 2"]
["citral","PPAR alpha",1,0,1,0,"PPARA","20656057",2010,"Citral, a component of lemongrass oil, activates PPAR? and ? and suppresses COX-2 expression.","20656057","citral","PPAR alpha"]
["citral","PPAR gamma",1,0,1,0,"PPARG","20656057",2010,"Citral, a component of lemongrass oil, activates PPAR? and ? and suppresses COX-2 expression.","20656057","citral","PPAR gamma"]
["citral","retinoic acid receptor alpha",1,0,1,0,"RARA","10704832",2000,"The control of Xenopus embryonic primary neurogenesis is mediated by retinoid signalling in the neurectoderm.","10704832","citral","retinoic acid receptor alpha"]
["Corticosterone","farnesoid X-activated receptor",0,0,1,0,"NR1H4","22643070",2012,"FXR agonist GW4064 increases plasma glucocorticoid levels in C57BL/6 mice.","22643070","Corticosterone","farnesoid X-activated receptor"]
["Corticosterone","pregnane X receptor",0,0,1,0,"NR1I2","12447992",2003,"Development of the fetal intestine in mice lacking the glucocorticoid receptor (GR).","12447992","Corticosterone","pregnane X receptor"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2573552",1989,"The determination of the adrenal medullary cell fate during embryogenesis.","2573552","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","10103082",1999,"Episodic corticosterone treatment accelerates kindling epileptogenesis and triggers long-term changes in hippocampal CA1 cells, in the fully kindled state.","10103082","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","13129852",2004,"Low endogenous glucocorticoid allows induction of kidney cortical cyclooxygenase-2 during postnatal rat development.","13129852","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","19001548",2009,"Regulation of glucocorticoid sensitivity in thymocytes from burn-injured mice.","19001548","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","22371048",2013,"Adenosine A(2A) receptor blockade reverts hippocampal stress-induced deficits and restores corticosterone circadian oscillation.","22371048","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","1630584",1992,"Type II corticosteroid receptor-like immunoreactivity in the rat cerebellar cortex: differential regulation by corticosterone.","1630584","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","423267",1979,"Uptake and distribution of glucocorticoids in cell nuclei of rat heart in cell-free system: dependence on concentrations and forms of added hormones.","423267","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","18657608",2008,"P38 MAPK mediates COX-2 gene expression by corticosterone in cardiomyocytes.","18657608","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2956460",1987,"In vivo competitive autoradiographic study of [3H]corticosterone and [3H]aldosterone binding sites within mouse brain hippocampus.","2956460","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","4048097",1985,"[Receptor binding of corticosterone in various structures of the rat brain after neonatal blockade of the hypophyseal-adrenal system].","4048097","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","23386218",2013,"Corticosterone suppresses the proliferation of RAW264.7 macrophage cells via glucocorticoid, but not mineralocorticoid, receptor.","23386218","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,1,"NR3C1","20717994",2011,"Long-term corticosterone treatment induced lobe-specific pathology in mouse prostate.","20717994","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","12076728",2002,"Corticosterone administration to rat pups, but not maternal separation, affects sexual maturation and glucocorticoid receptor immunoreactivity in the testis.","12076728","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","23380532",2013,"Effects of group housing on stress induced emotional and neuroendocrine alterations.","23380532","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","16503919",2006,"Acute activation of hippocampal glucocorticoid receptors results in different waves of gene expression throughout time.","16503919","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","19766402",2010,"Regulation of cortical and hippocampal 5-HT(1A) receptor function by corticosterone in GR+/- mice.","19766402","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","16626867",2006,"I.c.v. administration of the nonsteroidal glucocorticoid receptor antagonist, CP-472555, prevents exacerbated hypoglycemia during repeated insulin administration.","16626867","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","1786826",1991,"[The effect of antibiotics on the function of type-II and -III glucocorticoid receptors].","1786826","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","23295739",2013,"Adaptive changes in basal and stress-induced HPA activity in lactating and post-lactating female rats.","23295739","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","1511412",1992,"Endocrine mediation of psychosocial stressor effects on mouse mammary tumor growth.","1511412","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","18615595",2008,"Dexamethasone and corticosterone induce similar, but not identical, muscle wasting responses in cultured L6 and C2C12 myotubes.","18615595","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","22327185",2012,"Predator stress-induced persistent emotional arousal is associated with alterations of plasma corticosterone and hippocampal steroid receptors in rat.","22327185","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","19769949",2009,"Neuroendocrine responses in neonatal mother-deprived rabbits.","19769949","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2080146",1990,"[The receptor binding of corticosterone in the monoaminergic structures of the rat brain after a neonatal block of the hypophysis-adrenal system].","2080146","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2593115",1989,"Characterization of glucocorticoid receptors bound with corticosterone.","2593115","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","14962076",2004,"The dynamics of the hypothalamic-pituitary-adrenal axis during maternal deprivation.","14962076","Corticosterone","Receptors, Glucocorticoid"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L132,L132)","v":"Corticosterone"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M132,M132)","v":"Receptors, Glucocorticoid"},0,0,1,0,"NR3C1",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K132,K132)","v":"1484876"},1992,"Effects of adrenal steroid agonists on food intake and macronutrient selection.","1484876","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2594422",1989,"[The activation of specific type-III glucocorticoid receptors by pyrazolone series preparations].","2594422","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","1783093",1991,"Melatonin and adrenal cortex steroid production: in vivo and in vitro studies.","1783093","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3765499",1986,"[Changes in the level of glucocorticoid receptors in rat tissues on exogenous and endogenous increases in glucocorticoid levels].","3765499","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","17848165",2007,"Corticosterone impairs dendritic cell maturation and function.","17848165","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","18679041",2008,"Rapid inhibition of ATP-induced currents by corticosterone in rat dorsal root ganglion neurons.","18679041","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","1666241",1991,"The effect of immobilization and insulin-induced hypoglycemia on ACTH and corticosterone release in aging Brown-Norway rats.","1666241","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","12559836",2002,"Gene x environment interaction and cognitive performance: animal studies on the role of corticosterone.","12559836","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","18665386",2008,"Lipogenesis impaired in periparturient rats exposed to altered gravity is independent of prolactin and glucocorticoid secretion.","18665386","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2063198",1991,"A corticosteroid receptor in neuronal membranes.","2063198","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3420111",1988,"Corticosterone regulates the level of hepatic glucocorticoid receptors in mice.","3420111","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","16959332",2006,"Early weaning augments neuroendocrine stress responses in mice.","16959332","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","17697336",2007,"Corticosterone mediates electroacupuncture-produced anti-edema in a rat model of inflammation.","17697336","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","4079382",1985,"Biopotency of corticosterone and dexamethasone in causing glucocorticoid receptor downregulation.","4079382","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","23512717",2013,"Inhibition of cystathionine ?-synthase is associated with glucocorticoids over-secretion in psychological stress-induced hyperhomocystinemia rat liver.","23512717","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","1008886",1976,"Evidence that natural vs synthetic steroid hormones bind to physicochemically distinct cellular receptors.","1008886","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","206084",1978,"Inverse effects of corticosterone and thyroxine on glucocorticoid binding sites in the anterior pituitary gland.","206084","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","10371714",1999,"Support for a bimodal role for type II adrenal steroid receptors in spatial memory.","10371714","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","21729713",2011,"Local metabolism of glucocorticoids in Prague hereditary hypertriglyceridemic rats--effect of hypertriglyceridemia and gender.","21729713","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","22432149",2001,"Acute exposure to a novel stressor further reduces the habituated corticosterone response to restraint in rats.","22432149","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2353583",1990,"Long-lasting reduction of glucocorticoid receptor immunoreactivity in the hippocampal field CA1 but not in the dentate gyrus after neonatal treatment with corticosterone in the rat.","2353583","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","16223244",2005,"Genetically encoded stress indicator for noninvasively imaging endogenous corticosterone in living mice.","16223244","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","23544271",2013,"Glucocorticoid-induced hypertension and cardiac injury: effects of mineralocorticoid and glucocorticoid receptor antagonism.","23544271","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","15153751",2004,"Mineralo- and glucocorticoid receptor mrnas are differently regulated by corticosterone in the rat hippocampus and anterior pituitary.","15153751","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","20668026",2010,"Chronic corticosterone exposure increases expression and decreases deoxyribonucleic acid methylation of Fkbp5 in mice.","20668026","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","17927667",2007,"Effect of the glucocorticoid receptor antagonist Org 34850 on basal and stress-induced corticosterone secretion.","17927667","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2542001",1989,"Pharmacological evidence that the inhibition of diurnal adrenocorticotropin secretion by corticosteroids is mediated via type I corticosterone-preferring receptors.","2542001","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","18096163",2008,"Long-term behavioral and neuroendocrine alterations following chronic social stress in mice: implications for stress-related disorders.","18096163","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,1,"NR3C1","10880674",2000,"Chronic corticosterone impairs inhibitory avoidance in rats: possible link with atrophy of hippocampal CA3 neurons.","10880674","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","12538030",2003,"Characterization of glucocorticoid receptor translocation, cytoplasmic IkappaB, nuclear NFkappaB, and activation of NFkappaB in T lymphocytes exposed to stress-inducible concentrations of corticosterone in vivo.","12538030","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","22814115",2012,"Altered expression of glucocorticoid receptor and corticotropin-releasing factor in the central amygdala in response to elevated corticosterone.","22814115","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","12818705",2003,"A spoonful of sugar: feedback signals of energy stores and corticosterone regulate responses to chronic stress.","12818705","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","1088296",1976,"Structure-activity relationship and the mode of action of corticosteroid feedback on the secretion of corticotrophin-releasing factor (corticoliberin).","1088296","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","23254925",2013,"Differential effects of environmental enrichment and isolation housing on the hormonal and neurochemical responses to stress in the prefrontal cortex of the adult rat: relationship to working and emotional memories.","23254925","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2550833",1989,"On the role of brain mineralocorticoid (type I) and glucocorticoid (type II) receptors in neuroendocrine regulation.","2550833","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","19121305",2009,"Critical time-window for the actions of adrenal glucocorticoids in behavioural sensitisation to cocaine.","19121305","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","12876428",2003,"Postnatal touch stimulation acutely alters corticosterone levels and glucocorticoid receptor gene expression in the neonatal rat.","12876428","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","17760789",2007,"Effects of prenatal ethanol exposure on basal limbic-hypothalamic-pituitary-adrenal regulation: role of corticosterone.","17760789","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","21806804",2011,"Altered placental development in undernourished rats: role of maternal glucocorticoids.","21806804","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3449126",1987,"Normal levels of serum corticosterone and hepatic glucocorticoid receptors in obese (fa/fa) rats.","3449126","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3443807",1987,"Relative occupation of type-I and type-II corticosteroid receptors in rat brain following stress and dexamethasone treatment: functional implications.","3443807","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","19816761",2009,"Maternal separation alters nerve growth factor and corticosterone levels but not the DNA methylation status of the exon 1(7) glucocorticoid receptor promoter region.","19816761","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","12545895",2001,"[The actions of glucocorticoid receptor and 11 beta-hydroxysteroid dehydrogenases in the brain].","12545895","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","16285136",2005,"Visualizing stress.","16285136","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","16621323",2006,"Corticosterone response to acute stress in a mouse model of Fragile X syndrome.","16621323","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2826920",1987,"Equivalent affinity of aldosterone and corticosterone for type I receptors in kidney and hippocampus: direct binding studies.","2826920","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,1,"NR3C1","23044404",2013,"Mineralocorticoid receptor antagonist spironolactone prevents chronic corticosterone induced depression-like behavior.","23044404","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","22343460",2012,"A refined blood collection method for quantifying corticosterone.","22343460","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2170742",1990,"[The role of glucocorticoids in the post-vibration changes in inhibition mediation in the brain structures].","2170742","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","22043926",2012,"Plasma corticosterone elevation inhibits the activation of nuclear factor kappa B (NFKB) in the Syrian hamster pineal gland.","22043926","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","23072107",2012,"[Signal molecular and hormonal mechanisms of formation of the hypoxic preconditioning protective effects].","23072107","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","22926326",2012,"Pharmacological characterization of intracellular glucocorticoid receptors in nine tissues from house sparrow (Passer domesticus).","22926326","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3697785",1986,"Loss of 3H-corticosterone binding capacity in hippocampal slices maintained in vitro.","3697785","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3702449",1986,"Corticosteroid receptors in rat hippocampal sections: effect of adrenalectomy and corticosterone replacement.","3702449","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","12453484",2002,"Corticosterone and stress reduce synaptic potentiation in mouse hippocampal slices with mild stimulation.","12453484","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","15013364",2004,"Glucocorticoid pretreatment induces cytokine overexpression and nuclear factor-kappaB activation in macrophages.","15013364","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2905986",1988,"Comparison of the effects of dexamethasone 21-acetate and corticosterone on glucocorticoid cytosol receptor depletion and induction of TAT in rat liver.","2905986","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2796609",1989,"Corticosterone's dual metabolic actions.","2796609","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3675473",1987,"Disuse atrophy, plasma corticosterone, and muscle glucocorticoid receptor levels.","3675473","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","1504012",1992,"Glucocorticoid-recognizing and -effector sites in rat liver plasma membrane. Kinetics of corticosterone uptake by isolated membrane vesicles--I. Binding and transport.","1504012","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","21146149",2011,"Effect of high-dose total body irradiation on ACTH, corticosterone, and catecholamines in the rat.","21146149","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2724956",1989,"Comparison of the biopotency of corticosterone and dexamethasone acetate in glucocorticoid receptor down regulation in rat liver.","2724956","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","1235229",1975,"Corticosteroid receptors in the central nervous system of the rat.","1235229","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","12421628",2002,"Orphanin FQ-induced hyperphagia is mediated by corticosterone and central glucocorticoid receptors.","12421628","Corticosterone","Receptors, Glucocorticoid"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L196,L196)","v":"Corticosterone"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M196,M196)","v":"Receptors, Glucocorticoid"},0,0,1,0,"NR3C1",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K196,K196)","v":"446377"},1979,"The intracellular distribution of natural and synthetic glucocorticoids in the AtT-20 cell.","446377","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","12447992",2003,"Development of the fetal intestine in mice lacking the glucocorticoid receptor (GR).","12447992","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","22962255",2012,"Molecular basis for glucocorticoid induction of the Kruppel-like factor 9 gene in hippocampal neurons.","22962255","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","12446582",2002,"Corticosterone infused intracerebroventricularly inhibits energy storage and stimulates the hypothalamo-pituitary axis in adrenalectomized rats drinking sucrose.","12446582","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","1570300",1992,"Guanyl nucleotides modulate binding to steroid receptors in neuronal membranes.","1570300","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","229836",1979,"[3H] Corticosterone binding activity of adrenal incubation media in response to in vivo and in vitro ACTH stimulation.","229836","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","17911370",2007,"Glucocorticoid administration into the dorsal striatum [corrected] facilitates memory consolidation of inhibitory avoidance training but not of the context or footshock components.","17911370","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","21223994",2011,"Neonatal corticosterone administration impairs adult eyeblink conditioning and decreases glucocorticoid receptor expression in the cerebellar interpositus nucleus.","21223994","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","19577549",2009,"Glucocorticoid status affects antidepressant regulation of locus coeruleus tyrosine hydroxylase and dorsal raphé tryptophan hydroxylase gene expression.","19577549","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","23125098",2012,"Glucocorticoid mediates water avoidance stress-sensitized colon-bladder cross-talk via RSK2/PSD-95/NR2B in rats.","23125098","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2869788",1986,"Glucocorticoid regulation of hepatic cytosolic glucocorticoid receptors in vivo and its relationship to induction of tyrosine aminotransferase.","2869788","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2851747",1988,"Regulation of the central nervous system-pituitary-adrenal axis in rats after neonatal treatment with monosodium glutamate.","2851747","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","17307298",2007,"Cognitive impairment associated to HPA axis hyperactivity after maternal separation in rats.","17307298","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","12853419",2003,"c-fos reduces corticosterone-mediated effects on neurotrophic factor expression in the rat hippocampal CA1 region.","12853419","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","15667454",2004,"Gonadal steroid replacement reverses gonadectomy-induced changes in the corticosterone pulse profile and stress-induced hypothalamic-pituitary-adrenal axis activity of male and female rats.","15667454","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3740258",1986,"CBG does not restrict blood-brain barrier corticosterone transport in rabbits.","3740258","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2172045",1990,"[The receptor binding of 3H-corticosterone and the dopamine content in the striatum of rats with a predisposition to audiogenic seizures].","2172045","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","15897733",2005,"Corticosterone increases damage and cytosolic calcium accumulation associated with ethanol withdrawal in rat hippocampal slice cultures.","15897733","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","22940619",2012,"Corticosterone suppresses the proliferation of BV2 microglia cells via glucocorticoid, but not mineralocorticoid receptor.","22940619","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","1973648",1990,"Biological activity of the fatty acid ester metabolites of corticoids.","1973648","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","21122919",2011,"Chronic corticosterone administration from adolescence through early adulthood attenuates depression-like behaviors in mice.","21122919","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2757786",1989,"Adrenocorticoid receptor binding in the rat hippocampus: strain-dependent covariations with arousal and habituation to novelty.","2757786","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","16867184",2006,"Brief treatment with the glucocorticoid receptor antagonist mifepristone normalises the corticosterone-induced reduction of adult hippocampal neurogenesis.","16867184","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","14006",1977,"Interactions of corticosterone, 5alpha-dihydrocorticosterone and dexamethasone with proteins in rat-liver cytosol.","14006","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","18599619",2008,"Corticosteroids induce cyclooxygenase 1 expression in cardiomyocytes: role of glucocorticoid receptor and Sp3 transcription factor.","18599619","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","1860073",1991,"Life events-induced decrease of corticosteroid type I receptors is associated with reduced corticosterone feedback and enhanced vulnerability to amphetamine self-administration.","1860073","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","10843673",2000,"Glucocorticoids regulate TCR-induced elevation of CD4: functional implications.","10843673","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2766270",1989,"Inhibitory effect of antibody against basic fibroblast growth factor on androgen- or glucocorticoid-induced growth of Shionogi carcinoma 115 cells in serum-free culture.","2766270","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","15082020",2004,"Influence of chronic corticosterone and glucocorticoid receptor antagonism in the amygdala on fear conditioning.","15082020","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","15631890",2005,"Blockage of glucocorticoid, but not mineralocorticoid receptors prevents the persistent increase in circulating basal corticosterone concentrations following stress in the rat.","15631890","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,1,"NR3C1","2728387",1989,"[Experimental study of the antitumor properties and mechanism of action of kortifen].","2728387","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","17690167",2007,"Proteasome-dependent down-regulation of activated nuclear hippocampal glucocorticoid receptors determines dynamic responses to corticosterone.","17690167","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3561759",1986,"Receptor binding of corticosterone in some rat brain structures following neonatal blockade of the hypophyseoadrenal system.","3561759","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","15099681",2004,"(-)-nicotine ameliorates corticosterone's potentiation of N-methyl-d-aspartate receptor-mediated cornu ammonis 1 toxicity.","15099681","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","1649559",1991,"Effects of dexmedetomidine, a novel imidazole sedative-anesthetic agent, on adrenal steroidogenesis: in vivo and in vitro studies.","1649559","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","12472898",2002,"Corticosterone acutely prolonged N-methyl-d-aspartate receptor-mediated Ca2+ elevation in cultured rat hippocampal neurons.","12472898","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","19751738",2009,"Corticosterone manipulations alter morph-specific nestling provisioning behavior in male white-throated sparrows, Zonotrichia albicollis.","19751738","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","15105379",2004,"Long-term in vivo administration of glucocorticoid hormones attenuates their capacity to accelerate in vitro proliferation of rat splenic T cells.","15105379","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2289143",1990,"Increased type II glucocorticoid-receptor numbers and glucocorticoid-sensitive enzyme activities in the brain of the obese Zucker rat.","2289143","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","19016192",1999,"Ontogeny of gender-specific responsiveness to stress and glucocorticoids in the rat and its determination by the neonatal gonadal steroid environment.","19016192","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","19297425",2009,"Elevated corticosterone associated with food deprivation upregulates expression in rat skeletal muscle of the mTORC1 repressor, REDD1.","19297425","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","10401989",1999,"Panax ginseng blocks morphine-induced thymic apoptosis by lowering plasma corticosterone level.","10401989","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3609378",1987,"[Changes in corticosterone binding by receptors in various structures of the rat brain during immobilization stress].","3609378","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","17293045",2007,"Restraint-induced corticosterone secretion and hypothalamic CRH mRNA expression are augmented during acute withdrawal from chronic cocaine administration.","17293045","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","23159706",2013,"Inhibition of glucocorticoid receptors ameliorates hypobaric hypoxia induced memory impairment in rat.","23159706","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","21076867",2011,"Effect of treadmill exercise on blood glucose, serum corticosterone levels and glucocorticoid receptor immunoreactivity in the hippocampus in chronic diabetic rats.","21076867","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","19305644",2009,"Corticosterone alters AMPAR mobility and facilitates bidirectional synaptic plasticity.","19305644","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","21056056",2011,"Maternal corticosterone effects on hypothalamus-pituitary-adrenal axis regulation and behavior of the offspring in rodents.","21056056","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","19631743",2009,"Direct effects of corticosterone on ATP production by mitochondria from immortalized hypothalamic GT1-7 neurons.","19631743","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","15590919",2004,"Behavioral stress modifies hippocampal synaptic plasticity through corticosterone-induced sustained extracellular signal-regulated kinase/mitogen-activated protein kinase activation.","15590919","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","23178190",2013,"Corticosterone modulates fear responses and the expression of glucocorticoid receptors in the brain of high-anxiety rats.","23178190","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","4042993",1985,"Properties of binding of partially purified glucocorticoid receptor from rat liver with glucocorticoids of different biopotencies.","4042993","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","18571864",2008,"Corticosterone and related receptor expression are associated with increased beta-amyloid plaques in isolated Tg2576 mice.","18571864","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","21070780",2011,"Corticosterone mediates reciprocal changes in CB 1 and TRPV1 receptors in primary sensory neurons in the chronically stressed rat.","21070780","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","19332034",2009,"Corticosteroid effects on cellular physiology of limbic cells.","19332034","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","22918985",2013,"Acute stress, but not corticosterone, disrupts short- and long-term synaptic plasticity in rat dorsal subiculum via glucocorticoid receptor activation.","22918985","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","17923777",2008,"Glucocorticoid receptor mRNA expression in the hippocampal formation of male rats before and after pubertal development in response to acute or repeated stress.","17923777","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","18584335",2008,"Inhibitors of GSK-3 prevent corticosterone from inducing COX-1 expression in cardiomyocytes.","18584335","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2924129",1989,"Impaired up-regulation of type II corticosteroid receptors in hippocampus of aged rats.","2924129","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","14638841",2004,"The low-affinity glucocorticoid receptor regulates feeding and lipid breakdown in the migratory Gambel's white-crowned sparrow Zonotrichia leucophrys gambelii.","14638841","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","18448865",2008,"Modeling corticosteroid effects in a rat model of rheumatoid arthritis I: mechanistic disease progression model for the time course of collagen-induced arthritis in Lewis rats.","18448865","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","4030727",1985,"Appearance of new hepatic glucocorticoid binding proteins under various stressful conditions: relation to endogenous glucocorticoid secretion.","4030727","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","21511880",2011,"The HSP90 molecular chaperone cycle regulates cyclical transcriptional dynamics of the glucocorticoid receptor and its coregulatory molecules CBP/p300 during ultradian ligand treatment.","21511880","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","23937971",2013,"Exogenous prenatal corticosterone exposure mimics the effects of prenatal stress on adult brain stress response systems and fear extinction behavior.","23937971","Corticosterone","Receptors, Glucocorticoid"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L260,L260)","v":"Corticosterone"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M260,M260)","v":"Receptors, Glucocorticoid"},0,0,1,0,"NR3C1",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K260,K260)","v":"22610366"},2012,"Corticosterone regulates the expression of neuropeptide Y and reelin in MLO-Y4 cells.","22610366","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","305844",1978,"Binding of 3H-dexamethasone and 3H-corticosterone to rat liver cytosol during postnatal period.","305844","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3986609",1985,"The development of the glucocorticoid receptor system in the rat limbic brain. I. Ontogeny and autoregulation.","3986609","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","20170666",2010,"Exposure of the amygdala to elevated levels of corticosterone alters colonic motility in response to acute psychological stress.","20170666","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","24348341",2013,"Corticosterone rapidly increases thorns of CA3 neurons via synaptic/extranuclear glucocorticoid receptor in rat hippocampus.","24348341","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","11150568",2000,"Prenatal stress in rats: effects on plasma corticosterone, hippocampal glucocorticoid receptors, and maze performance.","11150568","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","18321654",2008,"Local facilitation of hippocampal metabotropic glutamate receptor-dependent long-term depression by corticosterone and dexamethasone.","18321654","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","22591911",2013,"Chronic effects of corticosterone on GIRK1-3 subunits and 5-HT1A receptor expression in rat brain and their reversal by concurrent fluoxetine treatment.","22591911","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","11164083",2000,"Effects of beta-phenylethylamine on the hypothalamo-pituitary-adrenal axis in the male rat.","11164083","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","15371517",2004,"Glucocorticoid effects on memory retrieval require concurrent noradrenergic activity in the hippocampus and basolateral amygdala.","15371517","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","19923852",2010,"Effects of acute cold stress on phagocytosis of apoptotic cells: the role of corticosterone.","19923852","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3986611",1985,"The development of the glucocorticoid receptor system in the rat limbic brain. III. Negative-feedback regulation.","3986611","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","24346134",2013,"All-trans retinoic acid-induced hypothalamus-pituitary-adrenal hyperactivity involves glucocorticoid receptor dysregulation.","24346134","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","18801418",2008,"Selective increases in regional brain glucocorticoid: a novel effect of chronic alcohol.","18801418","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2395928",1990,"Acute, chronic, and interactive effects of type I and II corticosteroid receptor stimulation on feeding and weight gain.","2395928","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","23864669",2013,"Corticosterone acts in the nucleus accumbens to enhance dopamine signaling and potentiate reinstatement of cocaine seeking.","23864669","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","17593325",2007,"Modeling receptor/gene-mediated effects of corticosteroids on hepatic tyrosine aminotransferase dynamics in rats: dual regulation by endogenous and exogenous corticosteroids.","17593325","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","16903861",2006,"Attenuating corticosterone levels on the day of memory assessment prevents chronic stress-induced impairments in spatial memory.","16903861","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","17592030",2007,"Peripheral mechanisms contributing to the glucocorticoid hypersensitivity in proopiomelanocortin null mice treated with corticosterone.","17592030","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","16439512",2006,"Effect of voluntary wheel running on circadian corticosterone release and on HPA axis responsiveness to restraint stress in Sprague-Dawley rats.","16439512","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","12559837",2002,"Stress and memory: opposing effects of glucocorticoids on memory consolidation and memory retrieval.","12559837","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","22948976",2012,"Stress-induced memory retrieval impairments: different time-course involvement of corticosterone and glucocorticoid receptors in dorsal and ventral hippocampus.","22948976","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3398855",1988,"Rapid corticosterone-induced changes in gene expression in rat hippocampus display type II glucocorticoid receptor specificity.","3398855","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","20169622",2010,"Endogenous glucocorticoids improve myelination via Schwann cells after peripheral nerve injury: An in vivo study using a crush injury model.","20169622","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","19208548",2009,"Changes in the placental glucocorticoid barrier during rat pregnancy: impact on placental corticosterone levels and regulation by progesterone.","19208548","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","10557342",1999,"Long-term exposure to high corticosterone levels attenuates serotonin responses in rat hippocampal CA1 neurons.","10557342","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","22641006",2012,"Fkbp52 heterozygosity alters behavioral, endocrine and neurogenetic parameters under basal and chronic stress conditions in mice.","22641006","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","21463019",2011,"Early adversity and serotonin transporter genotype interact with hippocampal glucocorticoid receptor mRNA expression, corticosterone, and behavior in adult male rats.","21463019","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","102509",1978,"Effects of calcium and magnesium ions on the interaction of corticosterone with rat brain cytosol receptor(s).","102509","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","1324155",1992,"Chronic estrogen-induced alterations in adrenocorticotropin and corticosterone secretion, and glucocorticoid receptor-mediated functions in female rats.","1324155","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","20180019",2010,"Inhibition of ATP-induced Ca2+ influx by corticosterone in dorsal root ganglion neurons.","20180019","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3015230",1986,"Effects of ACTH on the ligand-binding properties of the glucocorticoid receptor exerted not only via elevated levels of corticosteroids.","3015230","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","23907018",2013,"Evolution of hormone selectivity in glucocorticoid and mineralocorticoid receptors.","23907018","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","19494313",2009,"Social stress enhances allergen-induced airway inflammation in mice and inhibits corticosteroid responsiveness of cytokine production.","19494313","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3010158",1986,"Selective control by corticosterone of serotonin1 receptor capacity in raphe-hippocampal system.","3010158","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","20069608",2010,"Corticosterone exerts immunostimulatory effects on macrophages via endoplasmic reticulum stress.","20069608","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","17447165",2007,"Rapid inhibitory effect of corticosterone on histamine release from rat peritoneal mast cells.","17447165","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","18022153",2008,"An anti-immobility effect of exogenous corticosterone in mice.","18022153","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","22500955",2014,"Binge-like ethanol consumption increases corticosterone levels and neurodegneration whereas occupancy of type II glucocorticoid receptors with mifepristone is neuroprotective.","22500955","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3237668",1988,"[Corticosterone receptor binding by various brain structures in extreme body states].","3237668","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3224651",1988,"The corticosterone receptive system in the brain of Tupaia belangeri visualized by in vivo autoradiography.","3224651","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","24117520",2014,"Corticosterone targets distinct steps of synaptic transmission via concentration specific activation of mineralocorticoid and glucocorticoid receptors.","24117520","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3224266",1988,"Parallel changes in operant behavioral adaptation and hippocampal corticosterone binding in rats treated with trimethyltin.","3224266","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2158866",1990,"Ontogeny of mineralocorticoid (type 1) receptors in brain and pituitary: an in vivo autoradiographical study.","2158866","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","21887496",2011,"Environmental-induced differences in corticosterone and glucocorticoid receptor blockade of amphetamine self-administration in rats.","21887496","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","19235231",2009,"Corticosterone reduces dendritic complexity in developing hippocampal CA1 neurons.","19235231","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","20026014",2010,"Corticosterone basal levels and vulnerability to LPS-induced neuroinflammation in the rat brain.","20026014","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","22509272",2012,"Corticosterone induces rapid spinogenesis via synaptic glucocorticoid receptors and kinase networks in hippocampus.","22509272","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","18179829",2008,"Investigation of sex differences in behavioural, endocrine, and neural measures following repeated psychological stressor exposure.","18179829","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","1888673",1991,"Corticosterone regulation of brain and lymphoid corticosteroid receptors.","1888673","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","16510135",2006,"A 24 h corticosterone exposure exacerbates excitotoxic insult in rat hippocampal slice cultures independently of glucocorticoid receptor activation or protein synthesis.","16510135","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","10617155",2000,"Evaluation of apoptosis and the glucocorticoid receptor in the cartilage growth plate and metaphyseal bone cells of rats after high-dose treatment with corticosterone.","10617155","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","11277981",2001,"Glucocorticoids and serotonin alter glucocorticoid receptor (GR) but not mineralocorticoid receptor (MR) mRNA levels in fetal mouse hippocampal neurons, in vitro.","11277981","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","17481809",2007,"Prenatal undernutrition decreases the sensitivity of the hypothalamo-pituitary-adrenal axis in rat, as revealed by subcutaneous and intra-paraventricular dexamethasone challenges.","17481809","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3208285",1988,"Corticosterone effects on differentiation and X-ray-induced transformation of C3H/10T1/2 mouse cells.","3208285","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3177656",1988,"Corticosterone's metabolite is an agonist for Na+ transport stimulation in A6 cells.","3177656","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","1641426",1992,"Mimicking corticosterone's daily rhythm with specific receptor agonists: effects on food, water, and sodium intake.","1641426","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3260312",1988,"Diminished glucocorticoid tonus in obese strain (OS) chickens with spontaneous autoimmune thyroiditis: increased plasma levels of a physicochemically unaltered corticosteroid-binding globulin but normal total corticosterone plasma concentration and normal glucocorticoid receptor contents in lymphoid tissues.","3260312","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","24333411",2014,"Embryonic exposure to corticosterone modifies aggressive behavior through alterations of the hypothalamic pituitary adrenal axis and the serotonergic system in the chicken.","24333411","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","17451463",2007,"Glucocorticoids exert opposing effects on macrophage function dependent on their concentration.","17451463","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","24035860",2013,"Ginsenoside Rg1 exerts synergistic anti-inflammatory effects with low doses of glucocorticoids in vitro.","24035860","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","17552876",2008,"Liver glucocorticoid receptor and heat shock protein 70 levels in rats exposed to different stress models.","17552876","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","18399546",2008,"Distribution and corticosteroid regulation of glucocorticoid receptor in the brain of Xenopus laevis.","18399546","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","11238624",2001,"Endogenous glucocorticoids play a positive regulatory role in the anti-keyhole limpet hemocyanin in vivo antibody response.","11238624","Corticosterone","Receptors, Glucocorticoid"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L324,L324)","v":"Corticosterone"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M324,M324)","v":"Receptors, Glucocorticoid"},0,0,1,0,"NR3C1",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K324,K324)","v":"15477372"},2004,"Rapid glucocorticoid mediation of suppressed testosterone biosynthesis in male mice subjected to immobilization stress.","15477372","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","1758616",1991,"Receptor binding of corticosterone in monoaminergic structures of the brain of rats after neonatal blockade of the hypophyseoadrenal system.","1758616","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","10575090",1999,"Long-term changes in mineralocorticoid and glucocorticoid receptor occupancy following exposure to an acute stressor.","10575090","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","1883487",1991,"Self-inhibition of steroid secretion by amphibian adrenocortical cells is not mediated through glucocorticoid receptors.","1883487","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","1753450",1991,"Effects of hippocampal neurotoxicant, trimethyltin, on corticosterone response to a swim stress and glucocorticoid binding capacity in the hippocampus in rats.","1753450","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","11212517",2000,"[Changes in the hormonal function of the hypophysis-adrenal system by administration of cortisol in 'fixed' phases of the postnatal ontogenesis in rats].","11212517","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","1657218",1991,"Evaluation of glucocorticoid-induced DNA fragmentation in mouse thymocytes by flow cytometry.","1657218","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","24081658",2013,"Cell-intrinsic regulation of murine dendritic cell function and survival by prereceptor amplification of glucocorticoid.","24081658","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","19157766",2009,"Somatotropin response in vitro to corticosterone and triiodothyronine during chick embryonic development: Involvement of type I and type II glucocorticoid receptors.","19157766","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3193846",1988,"ZK91587: a novel synthetic antimineralocorticoid displays high affinity for corticosterone (type I) receptors in the rat hippocampus.","3193846","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","18172209",2008,"Stress blunts serotonin- and hypocretin-evoked EPSCs in prefrontal cortex: role of corticosterone-mediated apical dendritic atrophy.","18172209","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","18077099",2008,"Prenatal stress does not alter innate novelty-seeking behavioral traits, but differentially affects individual differences in neuroendocrine stress responsivity.","18077099","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","15725340",2005,"Corticosterone modulates noradrenaline-induced melatonin synthesis through inhibition of nuclear factor kappa B.","15725340","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","10941148",2000,"Prolonged corticosterone treatment of adult rats inhibits the proliferation of oligodendrocyte progenitors present throughout white and gray matter regions of the brain.","10941148","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","10958156",2000,"Effects of cocaine self-administration on plasma corticosterone in rats: relationship to hippocampal type II glucocorticoid receptors.","10958156","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","19368803",2009,"Dose-dependent effects of corticosterone on nuclear glucocorticoid receptors and their binding to DNA in the brain and pituitary of the rat.","19368803","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","17290878",2006,"[Influence of prenatal stress on the rat hypothalamic-pituitary-adrenal axis activity: the role of the brain glycocorticoid receptors].","17290878","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3386270",1988,"Corticosteroid receptor analyses in rat and hamster brains reveal species specificity in the type I and type II receptors.","3386270","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","10718920",2000,"Transcriptional repression of the 5-HT1A receptor promoter by corticosterone via mineralocorticoid receptors depends on the cellular context.","10718920","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","21673157",2011,"Neonatal feed restriction modulates circulating levels of corticosterone and expression of glucocorticoid receptor and heat shock protein 70 in aged Japanese quail exposed to acute heat stress.","21673157","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","23637179",2013,"Glucocorticoid signaling in myeloid cells worsens acute CNS injury and inflammation.","23637179","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","24727947",2014,"Maternal tobacco smoke increased visceral adiposity and serum corticosterone levels in adult male rat offspring.","24727947","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","10960352",2000,"Novel nuclear corticosteroid binding in rat small intestinal epithelia.","10960352","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3828499",1987,"[Interstrain differences in cellular glucocorticoid reception in mice and the degree of suppression of normal killer activity during immobilization stress].","3828499","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","15710457",2005,"Corticosterone impairs MHC class I antigen presentation by dendritic cells via reduction of peptide generation.","15710457","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","10225114",1999,"[Dependence of the antineoplastic effect of hormonal cytostatic cortifen on expression of glucocorticoid receptors in brain tumor cells].","10225114","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","10363821",1999,"Effects of corticosterone on excitatory amino acid responses in dopamine-sensitive neurons in the ventral tegmental area.","10363821","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","24462390",2014,"Icariin attenuates glucocorticoid insensitivity mediated by repeated psychosocial stress on an ovalbumin-induced murine model of asthma.","24462390","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","12912871",2003,"Glucocorticoid receptors are downregulated in hepatic T lymphocytes in rats with experimental cholangitis.","12912871","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","16361444",2005,"Mineralocorticoid receptors are indispensable for nongenomic modulation of hippocampal glutamate transmission by corticosterone.","16361444","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","1337702",1992,"[The receptor binding of 3H-corticosterone by rat hepatocytes].","1337702","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","11890970",2002,"Involvement of corticosterone in cardiovascular responses to an open-field novelty stressor in freely moving rats.","11890970","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","1660971",1991,"The induction of corticosteroid actions on membrane properties of hippocampal CA1 neurons requires protein synthesis.","1660971","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","17689506",2007,"Daily cocaine self-administration under long-access conditions augments restraint-induced increases in plasma corticosterone and impairs glucocorticoid receptor-mediated negative feedback in rats.","17689506","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","21814189",2011,"Membrane mineralocorticoid but not glucocorticoid receptors of the dorsal hippocampus mediate the rapid effects of corticosterone on memory retrieval.","21814189","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2487358",1989,"Characterization of specific binding sites for corticosterone in mouse liver plasma membrane.","2487358","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","21820440",2011,"Corticosterone microinjected into nucleus pontis oralis increases tonic immobility in rats.","21820440","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","22760557",2012,"Environmental enrichment rescues female-specific hyperactivity of the hypothalamic-pituitary-adrenal axis in a model of Huntington's disease.","22760557","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","11903813",2002,"Centrally regulated blood pressure response to vasoactive peptides is modulated by corticosterone.","11903813","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","10938581",2000,"Corticosterone effects on BDNF expression in the hippocampus. Implications for memory formation.","10938581","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","24862220",2014,"Glucocorticoid receptor in prostate epithelia is not required for corticosteroid-induced epithelial hyperproliferation in the mouse prostate.","24862220","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","1871098",1991,"[Changes in plasma levels of corticosterone, testosterone and estradiol and their receptors in the lung cytosol in experimental fibrosing process in the lungs].","1871098","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","12757368",2002,"Chronic restraint stress induces an isoform-specific regulation on the neural cell adhesion molecule in the hippocampus.","12757368","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","10914486",2000,"Age-associated increase of basal corticosterone levels decreases ED2high, NF-kappaBhigh activated macrophages.","10914486","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","18252955",2008,"Effect of the glucocorticoid receptor antagonist Org 34850 on fast and delayed feedback of corticosterone release.","18252955","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","22128027",2012,"Acute stress increases the synthesis of 7?-hydroxypregnenolone, a new key neurosteroid stimulating locomotor activity, through corticosterone action in newts.","22128027","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","18703410",2008,"Development of the ACTH and corticosterone response to acute hypoxia in the neonatal rat.","18703410","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,1,"NR3C1","22735575",2012,"Strain differences in the effects of chronic corticosterone exposure in the hippocampus.","22735575","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","17644267",2007,"Glucocorticoid receptor activation is involved in producing abnormal phenotypes of single-prolonged stress rats: a putative post-traumatic stress disorder model.","17644267","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","1319007",1992,"Diurnal corticotropin-releasing hormone mRNA variation in the hypothalamus exhibits a rhythm distinct from that of plasma corticosterone.","1319007","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","22750445",2012,"Glucocorticoids interact with the noradrenergic arousal system in the nucleus accumbens shell to enhance memory consolidation of both appetitive and aversive taste learning.","22750445","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","22186023",2012,"Pharmacological interference with the glucocorticoid system influences symptoms and lifespan in a mouse model of Rett syndrome.","22186023","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","16809449",2006,"Corticosterone can act at the posterior paraventricular thalamus to inhibit hypothalamic-pituitary-adrenal activity in animals that habituate to repeated stress.","16809449","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","573979",1978,"Influence of social environment and of drugs on 3H-corticosterone uptake in various brain areas.","573979","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","17614213",2007,"The acceleration of amygdala kindling epileptogenesis by chronic low-dose corticosterone involves both mineralocorticoid and glucocorticoid receptors.","17614213","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","11783231",1999,"[Effects of kidney nourishing and spleen invigorating recipes on glucocorticoid receptors of pulmonary tissue and plasma corticosterone in asthmatic rats].","11783231","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","1659874",1991,"Regulation of basal ACTH secretion by corticosterone is mediated by both type I (MR) and type II (GR) receptors in rat brain.","1659874","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","11751610",2002,"11Beta-hydroxysteroid dehydrogenase 1 transforms 11-dehydrocorticosterone into transcriptionally active glucocorticoid in neonatal rat heart.","11751610","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","20388959",2009,"Ischemic preconditioning attenuates gastric ischemia-reperfusion injury through involvement of glucocorticoids.","20388959","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","22674501",2012,"Effect of neonatal respiratory infection on adult BALB/c hippocampal glucocorticoid and mineralocorticoid receptors.","22674501","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","16033944",2005,"Corticosterone slowly enhances miniature excitatory postsynaptic current amplitude in mice CA1 hippocampal cells.","16033944","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","24484684",2014,"Regulation of corticosterone function during early weaning and effects on gastric cell proliferation.","24484684","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","15959917",2005,"Corticosterone shifts different forms of synaptic potentiation in opposite directions.","15959917","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2226278",1990,"Effect of corticosterone and dexamethasone on glucocorticoid receptor in lactating rat mammary gland.","2226278","Corticosterone","Receptors, Glucocorticoid"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L388,L388)","v":"Corticosterone"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M388,M388)","v":"Receptors, Glucocorticoid"},0,0,1,0,"NR3C1",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K388,K388)","v":"19211980"},2008,"Effects of co-administration of fluoxetine or tianeptine with metyrapone on immobility time and plasma corticosterone concentration in rats subjected to the forced swim test.","19211980","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","23800381",2013,"Inhibitory effects of forced swim stress and corticosterone on the acquisition but not expression of morphine-induced conditioned place preference: involvement of glucocorticoid receptor in the basolateral amygdala.","23800381","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","11742989",2001,"Glucocorticoid hormones inhibit food-induced phase-shifting of peripheral circadian oscillators.","11742989","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","15301440",2004,"Delayed effects of chronic variable stress during peripubertal-juvenile period on hippocampal morphology and on cognitive and stress axis functions in rats.","15301440","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","10515885",1999,"Early maturation of T-cell progenitors in the absence of glucocorticoids.","10515885","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","17182006",2007,"Hexachlorobenzene as hormonal disruptor--studies about glucocorticoids: their hepatic receptors, adrenal synthesis and plasma levels in relation to impaired gluconeogenesis.","17182006","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","4027612",1985,"Down-regulation of neural corticosterone receptors by corticosterone and dexamethasone.","4027612","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3967077",1985,"[Corticosterone reception by alveolar macrophages when their functional activity has changed].","3967077","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","20379891",2010,"Gene expression of hepatic glucocorticoid receptor NR3C1 and correlation with plasmatic corticosterone in Italian chickens.","20379891","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","1000024",1976,"Human liver corticosterone receptors.","1000024","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","444568",1979,"Corticosterone binding in AtT-20 pituitary tumor cell cytosol: evidence for one class of binding site for both natural and synthetic glucocorticoids.","444568","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","21647420",2011,"Long-term continuous corticosterone treatment decreases VEGF receptor-2 expression in frontal cortex.","21647420","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","1320217",1992,"Basal ACTH, corticosterone and corticosterone-binding globulin levels over the diurnal cycle, and age-related changes in hippocampal type I and type II corticosteroid receptor binding capacity in young and aged, handled and nonhandled rats.","1320217","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3374760",1988,"Stimulation of pro-opiomelanocortin gene expression by glucocorticoids in the denervated rat intermediate pituitary gland.","3374760","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","16814878",2006,"Glucocorticoid receptors in lateral septum are involved in the modulation of the emotional sequelae induced by social defeat.","16814878","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","18719621",2009,"A history of corticosterone exposure regulates fear extinction and cortical NR2B, GluR2/3, and BDNF.","18719621","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","24552400",2014,"Molecular basis for the activation of gonadotropin-inhibitory hormone gene transcription by corticosterone.","24552400","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","17396235",2007,"Transcriptional regulation of intronic calcium-activated potassium channel SK2 promoters by nuclear factor-kappa B and glucocorticoids.","17396235","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","23736296",2013,"Glucocorticoid-dependent hippocampal transcriptome in male rats: pathway-specific alterations with aging.","23736296","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","18485334",2008,"Time-course of immediate early gene expression in hippocampal subregions of adrenalectomized rats after acute corticosterone challenge.","18485334","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8888379",1996,"Facilitation of ethanol consumption by intracerebroventricular infusions of corticosterone.","8888379","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","722792",1978,"Glucocorticoid-binding proteins of rat heart cytosol and their possible role in the transfer of glucocorticoids into nuclei.","722792","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","7232365",1981,"[Glucocorticoid receptor content in the cytoplasm of human peripheral leukocytes].","7232365","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","7179352",1982,"Characterization of [3H] corticosterone binding activity in adrenal incubation media.","7179352","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","7304191",1981,"Corticosterone binding in myocardial tissue of rats after chronic stress and adrenalectomy.","7304191","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","7956914",1994,"Effects of selective type I and II adrenal steroid agonists on immune cell distribution.","7956914","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","9379116",1997,"Glucocorticoids inhibit bone resorption by isolated rat osteoclasts by enhancing apoptosis.","9379116","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","7155298",1982,"Regulation of glucocorticoid receptors in brain by corticosterone treatment of adrenalectomized rats.","7155298","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","731146",1978,"Specific interaction of corticosteroids with binding sites in the plasma membranes of the rat anterior pituitary gland.","731146","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","7363083",1980,"Hippocampal cytosol binding capacity of corticosterone: no depletion with nuclear loading.","7363083","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","9364623",1997,"1996 Curt P. Richter Award. Effects of viral infection on corticosterone secretion and glucocorticoid receptor binding in immune tissues.","9364623","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","7190104",1980,"[Specific cytoplasmic rat liver glucocorticoid receptors during immobilization stress].","7190104","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","6885009",1983,"Antagonistic effects of aldosterone on corticosterone-mediated changes in exploratory behavior of adrenalectomized rats.","6885009","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","9569012",1998,"Glucocorticoid-recognizing and -effector sites in rat liver plasma membrane. Kinetics of corticosterone uptake by isolated membrane vesicles. III. Specificity and stereospecificity.","9569012","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","9569008",1998,"Decreased apparent affinity of corticosterone for colonic crypt glucocorticoid receptors is dependent on the cellular milieu and is distinct from corticosterone metabolism.","9569008","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","9566508",1998,"Regulation of hippocampal theta activity by corticosterone: opposing functions of mineralocorticoid and glucocorticoid receptors.","9566508","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8091838",1994,"[Age dependent changes in signal transduction of glucocorticoid hormones after physiological stress in liver cells of male Wistar rats].","8091838","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","672491",1978,"[In vitro radioisotope analysis in evaluation of corticosterone binding by the hepatocyte receptors].","672491","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","6747497",1984,"Effect of adrenalectomy and steroid treatment on rat skin cytosol glucocorticoid receptor.","6747497","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","6748638",1984,"In vitro binding of tritiated glucocorticoids directly on unfixed rat brain sections.","6748638","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8064637",1994,"Dexamethasone nonsuppression in transgenic mice expressing antisense RNA to the glucocorticoid receptor.","8064637","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","7119118",1982,"Rat anterior pituitary. Distinction of an approximately 8S, corticosterone-preferring species from dexamethasone-binding glucocorticoid receptors.","7119118","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","6846539",1983,"Corticosterone binding sites along the rat nephron.","6846539","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","7150966",1982,"[3H] Corticosterone binding in rat superior cervical ganglion.","7150966","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","6892091",1982,"Hippocampal glucocorticoid binding: serotoninergic regulation and drug effects; relevance to behavioral-endocrine activities and depression.","6892091","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","9473772",1998,"Dietary energy restriction in the SENCAR mouse: elevation of glucocorticoid hormone levels but no change in distribution of glucocorticoid receptor in epidermal cells.","9473772","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","692127",1978,"Reduction in [3H]-corticosterone binding to cytoplasmic receptors in the brain of diabetic rats.","692127","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8646565",1995,"Immune and endocrine aspects of social and territorial behavior in male rabbits.","8646565","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","7053979",1982,"Vasopressin-related peptides increase the hippocampal corticosterone receptor capacity of diabetes insipidus (Brattleboro) rats.","7053979","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","7952288",1994,"The effect of corticosterone on reactivity to spatial novelty is mediated by central mineralocorticosteroid receptors.","7952288","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","7115818",1982,"[Accumulation by preparations of rat heart sarcolemma of protein-bound forms of glucocorticoids].","7115818","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","7130890",1982,"Influence of protein deficiency in rats on hormonal status and cytoplasmic glucocorticoid receptors in maternal and fetal tissues.","7130890","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","6836951",1983,"[Effect of type III glucocorticoid receptors on binding of corticosterone by the type II glucocorticoid receptors].","6836951","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8818401",1996,"Brain-corticosteroid hormone dialogue: slow and persistent.","8818401","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8754750",1996,"Specific nuclear localization of 11-dehydrocorticosterone in rat colon: evidence for a novel corticosteroid receptor.","8754750","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","7825914",1994,"Modulation of carbachol responsiveness by corticosteroid hormones in rat CA1 pyramidal neurons.","7825914","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8759750",1996,"Stress-induced changes in blood leukocyte distribution. Role of adrenal steroid hormones.","8759750","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","7825894",1994,"Behavioral and endocrine impact of impaired type II glucocorticoid receptor function in a transgenic mouse model.","7825894","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","7792820",1995,"Differences in temperature-sensitive receptor binding of glucocorticoids in spontaneously hypertensive and normotensive Wistar-Kyoto rats.","7792820","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","9039329",1996,"Mineralocorticoid receptors and glucocorticoid receptors.","9039329","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","7435121",1980,"Effects of glucocorticosteroids on prolactin and growth hormone production and characterization of the intracellular hormone receptors in rat pituitary tumour cells.","7435121","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,1,"NR3C1","7635930",1995,"The CORT-GR signal transduction pathway and CORT-induced cleft palate in H-2 congenic mice.","7635930","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","9097397",1997,"Intermittent morphine administration induces a long-lasting synergistic effect of corticosterone on dopamine D1 receptor functioning in rat striatal GABA neurons.","9097397","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","7675174",1995,"Strain-selective effects of corticosterone on locomotor sensitization to cocaine and on levels of tyrosine hydroxylase and glucocorticoid receptor in the ventral tegmental area.","7675174","Corticosterone","Receptors, Glucocorticoid"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L452,L452)","v":"Corticosterone"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M452,M452)","v":"Receptors, Glucocorticoid"},0,0,1,0,"NR3C1",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K452,K452)","v":"8848523"},1995,"Normal glucocorticoid fast feedback following chronic 50% corticosterone pellet treatment.","8848523","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8932731",1996,"Changes in plasma adrenocorticotropin, corticosterone, corticosteroid-binding globulin, and hippocampal glucocorticoid receptor occupancy/translocation in rat pups in response to stress.","8932731","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","7719726",1995,"Effects of peripheral versus central administration of the endogenous glucocorticoid, corticosterone, and the glucocorticoid receptor agonist, RU 28362, on LH release in male rats.","7719726","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","7735296",1995,"Negative feedback regulation following administration of chronic exogenous corticosterone.","7735296","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8874882",1996,"Opposite strain-dependent effects of post-training corticosterone in a passive avoidance task in mice: role of dopamine.","8874882","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8895366",1996,"Chronic brain glucocorticoid receptor blockade enhances the rise in circadian and stress-induced pituitary-adrenal activity.","8895366","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","902109",1977,"The ontogeny of corticosterone and dexamethasone receptors in rat brain.","902109","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","9227623",1997,"Chronic corticosterone treatment increases myocardial infarct size in rats with ischemia-reperfusion injury.","9227623","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","7410378",1980,"The effect of temperature and binding kinetics on the competitive binding assay of steroid potency in intact AtT-20 cells and cytosol.","7410378","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","7421211",1980,"Specific interaction of corticosteroids with components of the cell membrane which are involved in the translocation of the hormone into the intravesicular space of purified rat liver plasma membrane vesicles.","7421211","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","7421219",1980,"Evidence for a specific mineralocorticoid receptor in rat pituitary and brain.","7421219","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","6690273",1984,"Stress down-regulates corticosterone receptors in a site-specific manner in the brain.","6690273","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","7439665",1980,"Cytosol receptor glycoprotein for 1 alpha-hydroxycorticosterone in tissues of an elasmobranch fish (Raja ocellata).","7439665","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","704749",1978,"Modulation of high affinity GABA uptake into hippocampal synaptosomes by glucocorticoids.","704749","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","9308903",1997,"Regulation of hepatic cytochrome P450 2C11 by glucocorticoids.","9308903","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","7594229",1995,"Changes in glucocorticoid receptor immunoreactivity after adrenalectomy and corticosterone treatment in the rat testis.","7594229","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","7486601",1995,"Potential interactions between nimodipine and adrenal hormones.","7486601","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","7854039",1994,"Effects of adrenalectomy and type I or type II glucocorticoid receptor activation on AVP and CRH mRNA in the rat hypothalamus.","7854039","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","9212718",1997,"Glucocorticoid regulation of in vitro astrocyte phagocytosis.","9212718","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","9191104",1997,"Regulation of hippocampal 5-HT1A receptor mRNA and binding in transgenic mice with a targeted disruption of the glucocorticoid receptor.","9191104","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","7880452",1994,"Differential influence of corticosterone and dexamethasone on schedule-induced polydipsia in adrenalectomized rats.","7880452","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","7583298",1995,"Effects of adrenalectomy and corticosterone replacement on glucocorticoid receptor levels in rat brain tissue: a comparison between western blotting and receptor binding assays.","7583298","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8704740",1995,"A role for the mineralocorticoid receptor in a rapid and transient suppression of hippocampal 5-HT1A receptor mRNA by corticosterone.","8704740","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","873047",1977,"Localization and role of transcortin-like molecules in the anterior pituitary.","873047","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","7376973",1980,"Brain glucocorticoid receptor: correlation of in vivo uptake of corticosterone with behavioral, endocrine, and neuropharmacological events.","7376973","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","745425",1978,"Failure to interpret the behavioural effect of cortisol-21-sulphate by steroid-receptor interaction.","745425","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8584606",1995,"Corticosterone, brain mineralocorticoid receptors (MRs) and the activity of the hypothalamic-pituitary-adrenal (HPA) axis: the Lewis rat as an example of increased central MR capacity and a hyporesponsive HPA axis.","8584606","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","6147808",1984,"[Phasic changes in the glucocorticoid receptor level of the liver cytosol in rats in stress].","6147808","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","9765324",1998,"Corticosterone facilitates the acquisition of cocaine self-administration in rats: opposite effects of the type II glucocorticoid receptor agonist dexamethasone.","9765324","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","6338133",1983,"Confirmation of corticosterone and progesterone binding activity in Candida albicans.","6338133","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8510182",1993,"Association of glucocorticoid receptor immunoreactivity with cell membrane and transport vesicles in hippocampal and hypothalamic neurons of the rat.","8510182","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","6416633",1983,"[Binding of tritiated corticosterone by brain sections of adrenalectomized rats].","6416633","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","6482428",1984,"Relative binding affinity of steroids for the corticosterone receptor system in rat hippocampus.","6482428","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8174608",1994,"Corticosterone suppresses the expression of 5-HT1A receptor mRNA in rat dentate gyrus.","8174608","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","9700972",1998,"Corticosterone is permissive to the anxiolytic effect that results from the blockade of hippocampal mineralocorticoid receptors.","9700972","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","6171467",1981,"Immunoprecipitation assay of alpha-fetoprotein synthesis by cultured mouse hepatoma cells treated with estrogens and glucocorticoids.","6171467","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","6606562",1983,"Perinatal mother-offspring pituitary-adrenal interrelationship in rats: corticosterone in milk may affect adult life.","6606562","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","9698199",1998,"Acute rise in corticosterone facilitates 5-HT(1A) receptor-mediated behavioural responses.","9698199","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","9696701",1998,"Corticosterone increase inhibits stress-induced gastric erosions in rats.","9696701","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","9695134",1998,"Differential effects of neonatal handling on anxiety, corticosterone response to stress, and hippocampal glucocorticoid and serotonin (5-HT)2A receptors in Lewis rats.","9695134","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","6606910",1983,"[Dexamethasone and corticosterone binding by glucocorticoid-resistant and glucocorticoid-sensitive thymocytes in vitro and in vivo].","6606910","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","6616181",1983,"Quantitative autoradiography of [3H]corticosterone receptors in rat brain.","6616181","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8195711",1994,"Steroid production in the thymus: implications for thymocyte selection.","8195711","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8405126",1993,"Attenuation of hypercortisolemia in fawn-hooded rats by antidepressant drugs.","8405126","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8377934",1993,"The mesolimbic dopaminergic system exerts an inhibitory influence on brain corticosteroid receptor affinities.","8377934","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8382376",1993,"Mineralocorticoid and glucocorticoid receptor activities distinguished by nonreceptor factors at a composite response element.","8382376","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","9857968",1998,"Stress and long-term synaptic depression.","9857968","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8386934",1993,"The role of glucocorticoid activity in the inheritance of hypertension: studies in the rat.","8386934","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","6219183",1983,"Influence of streptozotocin-induced diabetes in pregnant rats on plasma corticosterone and progesterone levels and on cytoplasmic glucocorticoid receptors in fetal tissues.","6219183","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8396170",1993,"The role of the medial prefrontal cortex (cingulate gyrus) in the regulation of hypothalamic-pituitary-adrenal responses to stress.","8396170","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","6684831",1983,"[Interaction of transcortin and type III glucocorticoid receptors with type II glucocorticoid receptors in stress].","6684831","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","9826789",1998,"Corticosterone treatment differentially affects adrenocorticoid receptors expression and binding in the hippocampus and spinal cord of the rat.","9826789","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","976939",1976,"Sex differences in glucocorticoid binding to the adenohypophysis.","976939","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","6237653",1983,"Affinity of 18,19-dihydroxydeoxycorticosterone and 18-hydroxy-19-nor-deoxycorticosterone to aldosterone receptor and their mineralocorticoid activity.","6237653","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8284048",1993,"Modulation of the locomotor response to amphetamine by corticosterone.","8284048","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","6200696",1984,"Adrenal steroids as modulators of nerve cell function.","6200696","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","6310613",1983,"Renal mineralocorticoid receptors and hippocampal corticosterone-binding species have identical intrinsic steroid specificity.","6310613","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","6188228",1983,"Glucocorticoid receptor-mediated teratogenesis in the chick embryo.","6188228","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","6323138",1984,"The relationship between glucocorticoid biopotency and receptor binding in the AtT-20 cell.","6323138","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","9733199",1998,"Isolation-stress-induced facilitation of passive avoidance memory in the day-old chick.","9733199","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","6227474",1983,"Characterization of rat brain aldosterone receptors reveals high affinity for corticosterone.","6227474","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8353166",1993,"Indole-pyruvic acid, a tryptophan ketoanalogue, antagonizes the endocrine but not the behavioral effects of repeated stress in a model of depression.","8353166","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8349282",1993,"Glucocorticoids facilitate mineralocorticoid-induced sodium intake in the rat.","8349282","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","6617922",1983,"[Effects of irradiation on the cytosol glucocorticoid receptor and concentrations of corticosterone and cyclic nucleotides in the rat liver].","6617922","Corticosterone","Receptors, Glucocorticoid"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L516,L516)","v":"Corticosterone"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M516,M516)","v":"Receptors, Glucocorticoid"},0,0,1,0,"NR3C1",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K516,K516)","v":"6661643"},1983,"Corticosterone receptors decline in a site-specific manner in the aged rat brain.","6661643","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","6661618",1983,"Hippocampal corticosterone receptors and novelty-induced behavioral activity: effect of kainic acid lesion in the hippocampus.","6661618","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","6120119",1981,"Effect of high level of endogenous corticosterone on glucocorticoid receptors in the spleen of rats bearing AH130 tumors.","6120119","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","6127203",1982,"Glucocorticoid influence on tyrosine hydroxylase activity in mouse locus coeruleus during postnatal development.","6127203","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","6640333",1983,"[3H]corticosterone binding in the caudate-putamen.","6640333","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","9930625",1998,"Corticosterone binding to tissues of adrenalectomized lean and obese Zucker rats.","9930625","Corticosterone","Receptors, Glucocorticoid"]
["Corticosterone","PPAR alpha",0,0,1,0,"PPARA","24113770",2013,"Increased plasma corticosterone contributes to the development of alcoholic fatty liver in mice.","24113770","Corticosterone","PPAR alpha"]
["Corticosterone","PPAR gamma",0,0,1,0,"PPARG","22931956",2012,"Acute psychological stress accelerates reverse cholesterol transport via corticosterone-dependent inhibition of intestinal cholesterol absorption.","22931956","Corticosterone","PPAR gamma"]
["Corticosterone","PPAR gamma",0,0,1,0,"PPARG","17579631",2007,"Metabolic action of peroxisome proliferator-activated receptor gamma agonism in rats with exogenous hypercorticosteronemia.","17579631","Corticosterone","PPAR gamma"]
["Corticosterone","retinoic acid receptor alpha",0,0,1,0,"RARA","24346134",2013,"All-trans retinoic acid-induced hypothalamus-pituitary-adrenal hyperactivity involves glucocorticoid receptor dysregulation.","24346134","Corticosterone","retinoic acid receptor alpha"]
["cyproconazole","constitutive androstane receptor",1,0,1,1,"NR1I3","23721867",2013,"Dose-response involvement of constitutive androstane receptor in mouse liver hypertrophy induced by triazole fungicides.","23721867","cyproconazole","constitutive androstane receptor"]
["DDT","pregnane X receptor",0,0,1,1,"NR1I2","17984292",2008,"o,p'-DDT elicits PXR/CAR-, not ER-, mediated responses in the immature ovariectomized rat liver.","17984292","DDT","pregnane X receptor"]
["DDT","pregnane X receptor",0,0,1,0,"NR1I2","17035600",2007,"Pregnane X receptor-dependent induction of the CYP3A4 gene by o,p'-1,1,1,-trichloro-2,2-bis (p-chlorophenyl)ethane.","17035600","DDT","pregnane X receptor"]
["DDT","constitutive androstane receptor",0,0,1,1,"NR1I3","17984292",2008,"o,p'-DDT elicits PXR/CAR-, not ER-, mediated responses in the immature ovariectomized rat liver.","17984292","DDT","constitutive androstane receptor"]
["DDT","constitutive androstane receptor",0,0,1,1,"NR1I3","23684557",2013,"Dichlorodiphenyltrichloroethane technical mixture regulates cell cycle and apoptosis genes through the activation of CAR and ER? in mouse livers.","23684557","DDT","constitutive androstane receptor"]
["DDT","Receptors, Glucocorticoid",0,0,1,1,"NR3C1","11272408",2000,"Acute hepatotoxicity of DDT: effect on glucocorticoid receptors and serum transcortin.","11272408","DDT","Receptors, Glucocorticoid"]
["decamethrin","pregnane X receptor",0,0,1,1,"NR1I2","19326768",2008,"Pyrethroids: cytotoxicity and induction of CYP isoforms in human hepatocytes.","19326768","decamethrin","pregnane X receptor"]
["Dibutyl Phthalate","pregnane X receptor",1,0,1,1,"NR1I2","15901914",2005,"Di-n-butyl phthalate activates constitutive androstane receptor and pregnane X receptor and enhances the expression of steroid-metabolizing enzymes in the liver of rat fetuses.","15901914","Dibutyl Phthalate","pregnane X receptor"]
["Dibutyl Phthalate","constitutive androstane receptor",1,0,1,1,"NR1I3","15901914",2005,"Di-n-butyl phthalate activates constitutive androstane receptor and pregnane X receptor and enhances the expression of steroid-metabolizing enzymes in the liver of rat fetuses.","15901914","Dibutyl Phthalate","constitutive androstane receptor"]
["Dibutyl Phthalate","Receptors, Glucocorticoid",1,0,1,1,"NR3C1","19815848",2009,"Di (n-butyl) phthalate inhibits testosterone synthesis through a glucocorticoid-mediated pathway in rats.","19815848","Dibutyl Phthalate","Receptors, Glucocorticoid"]
["Dibutyl Phthalate","Receptors, Glucocorticoid",1,0,1,1,"NR3C1","20021852",2009,"[Glucocorticoid pathway mediated the inhibition of testosterone in rats exposed to dibutyl phthalate].","20021852","Dibutyl Phthalate","Receptors, Glucocorticoid"]
["Dibutyl Phthalate","PPAR alpha",1,0,1,0,"PPARA","18602967",2008,"Impact of diisobutyl phthalate and other PPAR agonists on steroidogenesis and plasma insulin and leptin levels in fetal rats.","18602967","Dibutyl Phthalate","PPAR alpha"]
["Dibutyl Phthalate","PPAR alpha",1,0,1,1,"PPARA","15901914",2005,"Di-n-butyl phthalate activates constitutive androstane receptor and pregnane X receptor and enhances the expression of steroid-metabolizing enzymes in the liver of rat fetuses.","15901914","Dibutyl Phthalate","PPAR alpha"]
["Dibutyl Phthalate","PPAR alpha",1,0,1,1,"PPARA","17497641",2007,"Effect of di(n-butyl) phthalate on testicular oxidative damage and antioxidant enzymes in hyperthyroid rats.","17497641","Dibutyl Phthalate","PPAR alpha"]
["Dibutyl Phthalate","PPAR alpha",1,0,1,1,"PPARA","17379376",2007,"Identification of differentially expressed genes in the testis of Sprague-Dawley rats treated with di(n-butyl) phthalate.","17379376","Dibutyl Phthalate","PPAR alpha"]
["Dibutyl Phthalate","PPAR gamma",1,0,1,0,"PPARG","18602967",2008,"Impact of diisobutyl phthalate and other PPAR agonists on steroidogenesis and plasma insulin and leptin levels in fetal rats.","18602967","Dibutyl Phthalate","PPAR gamma"]
["Dichlorodiphenyl Dichloroethylene","pregnane X receptor",1,1,1,1,"NR1I2","16764480",2006,"The persistent DDT metabolite, 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene, alters thyroid hormone-dependent genes, hepatic cytochrome P4503A, and pregnane X receptor gene expressions in Atlantic salmon (Salmo salar) Parr.","16764480","Dichlorodiphenyl Dichloroethylene","pregnane X receptor"]
["Dichlorodiphenyl Dichloroethylene","pregnane X receptor",1,1,1,0,"NR1I2","12869653",2003,"The environmental pollutant 1,1-dichloro-2,2-bis (p-chlorophenyl)ethylene induces rat hepatic cytochrome P450 2B and 3A expression through the constitutive androstane receptor and pregnane X receptor.","12869653","Dichlorodiphenyl Dichloroethylene","pregnane X receptor"]
["Dichlorodiphenyl Dichloroethylene","pregnane X receptor",1,1,1,1,"NR1I2","18925944",2008,"Species-specific regulation of PXR/CAR/ER-target genes in the mouse and rat liver elicited by o, p'-DDT.","18925944","Dichlorodiphenyl Dichloroethylene","pregnane X receptor"]
["Dichlorodiphenyl Dichloroethylene","constitutive androstane receptor",1,1,1,0,"NR1I3","12869653",2003,"The environmental pollutant 1,1-dichloro-2,2-bis (p-chlorophenyl)ethylene induces rat hepatic cytochrome P450 2B and 3A expression through the constitutive androstane receptor and pregnane X receptor.","12869653","Dichlorodiphenyl Dichloroethylene","constitutive androstane receptor"]
["Dichlorodiphenyl Dichloroethylene","constitutive androstane receptor",1,1,1,1,"NR1I3","18925944",2008,"Species-specific regulation of PXR/CAR/ER-target genes in the mouse and rat liver elicited by o, p'-DDT.","18925944","Dichlorodiphenyl Dichloroethylene","constitutive androstane receptor"]
["Diclofenac","PPAR gamma",0,0,1,0,"PPARG","19219624",2009,"Activation of macrophage peroxisome proliferator-activated receptor-gamma by diclofenac results in the induction of cyclooxygenase-2 protein and the synthesis of anti-inflammatory cytokines.","19219624","Diclofenac","PPAR gamma"]
["Diclofenac","PPAR gamma",0,0,1,0,"PPARG","20514536",2010,"The role of NF-?B and PPAR? in experimentally induced colorectal cancer and chemoprevention by cyclooxygenase-2 inhibitors.","20514536","Diclofenac","PPAR gamma"]
["Diclofenac","PPAR gamma",0,0,1,0,"PPARG","20485182",2010,"Modulation of inflammatory changes in early stages of colon cancer through activation of PPARgamma by diclofenac.","20485182","Diclofenac","PPAR gamma"]
["Diclofenac","PPAR gamma",0,0,1,0,"PPARG","19423341",2009,"Design, synthesis and insulin-sensitizing activity of indomethacin and diclofenac derivatives.","19423341","Diclofenac","PPAR gamma"]
["Diethylhexyl Phthalate","pregnane X receptor",1,0,1,1,"NR1I2","18332045",2008,"Phthalate induction of CYP3A4 is dependent on glucocorticoid regulation of PXR expression.","18332045","Diethylhexyl Phthalate","pregnane X receptor"]
["Diethylhexyl Phthalate","pregnane X receptor",1,0,1,1,"NR1I2","18332045",2008,"Phthalate induction of CYP3A4 is dependent on glucocorticoid regulation of PXR expression.","18332045","Diethylhexyl Phthalate","pregnane X receptor"]
["Diethylhexyl Phthalate","pregnane X receptor",1,0,1,1,"NR1I2","17003290",2006,"The endocrine disrupting chemical, diethylhexyl phthalate, activates MDR1 gene expression in human colon cancer LS174T cells.","17003290","Diethylhexyl Phthalate","pregnane X receptor"]
["Diethylhexyl Phthalate","pregnane X receptor",1,0,1,0,"NR1I2","15364542",2004,"Environmental phthalate monoesters activate pregnane X receptor-mediated transcription.","15364542","Diethylhexyl Phthalate","pregnane X receptor"]
["Diethylhexyl Phthalate","pregnane X receptor",1,0,1,0,"NR1I2","15364542",2004,"Environmental phthalate monoesters activate pregnane X receptor-mediated transcription.","15364542","Diethylhexyl Phthalate","pregnane X receptor"]
["Diethylhexyl Phthalate","pregnane X receptor",1,0,1,1,"NR1I2","19850644",2010,"Characterization of peroxisome proliferator-activated receptor alpha--independent effects of PPARalpha activators in the rodent liver: di-(2-ethylhexyl) phthalate also activates the constitutive-activated receptor.","19850644","Diethylhexyl Phthalate","pregnane X receptor"]
["Diethylhexyl Phthalate","pregnane X receptor",1,0,1,1,"NR1I2","19850644",2010,"Characterization of peroxisome proliferator-activated receptor alpha--independent effects of PPARalpha activators in the rodent liver: di-(2-ethylhexyl) phthalate also activates the constitutive-activated receptor.","19850644","Diethylhexyl Phthalate","pregnane X receptor"]
["Diethylhexyl Phthalate","pregnane X receptor",1,0,1,1,"NR1I2","17003290",2006,"The endocrine disrupting chemical, diethylhexyl phthalate, activates MDR1 gene expression in human colon cancer LS174T cells.","17003290","Diethylhexyl Phthalate","pregnane X receptor"]
["Diethylhexyl Phthalate","pregnane X receptor",1,0,1,1,"NR1I2","21227907",2011,"Selective phthalate activation of naturally occurring human constitutive androstane receptor splice variants and the pregnane X receptor.","21227907","Diethylhexyl Phthalate","pregnane X receptor"]
["Diethylhexyl Phthalate","pregnane X receptor",1,0,1,1,"NR1I2","21227907",2011,"Selective phthalate activation of naturally occurring human constitutive androstane receptor splice variants and the pregnane X receptor.","21227907","Diethylhexyl Phthalate","pregnane X receptor"]
["Diethylhexyl Phthalate","constitutive androstane receptor",1,0,1,1,"NR1I3","19850644",2010,"Characterization of peroxisome proliferator-activated receptor alpha--independent effects of PPARalpha activators in the rodent liver: di-(2-ethylhexyl) phthalate also activates the constitutive-activated receptor.","19850644","Diethylhexyl Phthalate","constitutive androstane receptor"]
["Diethylhexyl Phthalate","constitutive androstane receptor",1,0,1,0,"NR1I3","19211671",2009,"Di(2-ethylhexyl) phthalate is a highly potent agonist for the human constitutive androstane receptor splice variant CAR2.","19211671","Diethylhexyl Phthalate","constitutive androstane receptor"]
["Diethylhexyl Phthalate","constitutive androstane receptor",1,0,1,1,"NR1I3","21227907",2011,"Selective phthalate activation of naturally occurring human constitutive androstane receptor splice variants and the pregnane X receptor.","21227907","Diethylhexyl Phthalate","constitutive androstane receptor"]
["Diethylhexyl Phthalate","constitutive androstane receptor",1,0,1,1,"NR1I3","21227907",2011,"Selective phthalate activation of naturally occurring human constitutive androstane receptor splice variants and the pregnane X receptor.","21227907","Diethylhexyl Phthalate","constitutive androstane receptor"]
["Diethylhexyl Phthalate","constitutive androstane receptor",1,0,1,1,"NR1I3","19850644",2010,"Characterization of peroxisome proliferator-activated receptor alpha--independent effects of PPARalpha activators in the rodent liver: di-(2-ethylhexyl) phthalate also activates the constitutive-activated receptor.","19850644","Diethylhexyl Phthalate","constitutive androstane receptor"]
["Diethylhexyl Phthalate","constitutive androstane receptor",1,0,1,0,"NR1I3","19428328",2009,"Di-(2-ethylhexyl)-phthalate (DEHP) activates the constitutive androstane receptor (CAR): a novel signalling pathway sensitive to phthalates.","19428328","Diethylhexyl Phthalate","constitutive androstane receptor"]
["Diethylhexyl Phthalate","constitutive androstane receptor",1,0,1,0,"NR1I3","19428328",2009,"Di-(2-ethylhexyl)-phthalate (DEHP) activates the constitutive androstane receptor (CAR): a novel signalling pathway sensitive to phthalates.","19428328","Diethylhexyl Phthalate","constitutive androstane receptor"]
["Diethylhexyl Phthalate","constitutive androstane receptor",1,0,1,0,"NR1I3","19211671",2009,"Di(2-ethylhexyl) phthalate is a highly potent agonist for the human constitutive androstane receptor splice variant CAR2.","19211671","Diethylhexyl Phthalate","constitutive androstane receptor"]
["Diethylhexyl Phthalate","PPAR alpha",1,0,1,1,"PPARA","19344669",2009,"Clinically relevant concentrations of di (2-ethylhexyl) phthalate (DEHP) uncouple cardiac syncytium.","19344669","Diethylhexyl Phthalate","PPAR alpha"]
["Diethylhexyl Phthalate","PPAR alpha",1,0,1,0,"PPARA","20123618",2010,"The pollutant diethylhexyl phthalate regulates hepatic energy metabolism via species-specific PPARalpha-dependent mechanisms.","20123618","Diethylhexyl Phthalate","PPAR alpha"]
["Diethylhexyl Phthalate","PPAR alpha",1,0,1,0,"PPARA","20123631",2010,"To each his own: DEHP yields species-specific metabolic phenotypes.","20123631","Diethylhexyl Phthalate","PPAR alpha"]
["Diethylhexyl Phthalate","PPAR alpha",1,0,1,1,"PPARA","18829104",2008,"Maternal di-(2-ethylhexyl)-phthalate exposure influences essential fatty acid homeostasis in rat placenta.","18829104","Diethylhexyl Phthalate","PPAR alpha"]
["Diethylhexyl Phthalate","PPAR alpha",1,0,1,1,"PPARA","21354252",2011,"Hepatic peroxisome proliferator-activated receptor ? may have an important role in the toxic effects of di(2-ethylhexyl)phthalate on offspring of mice.","21354252","Diethylhexyl Phthalate","PPAR alpha"]
["Diethylhexyl Phthalate","PPAR alpha",1,0,1,1,"PPARA","17135395",2007,"Peroxisome proliferator-activated receptor alpha protects against glomerulonephritis induced by long-term exposure to the plasticizer di-(2-ethylhexyl)phthalate.","17135395","Diethylhexyl Phthalate","PPAR alpha"]
["Diethylhexyl Phthalate","PPAR alpha",1,0,1,1,"PPARA","21354252",2011,"Hepatic peroxisome proliferator-activated receptor ? may have an important role in the toxic effects of di(2-ethylhexyl)phthalate on offspring of mice.","21354252","Diethylhexyl Phthalate","PPAR alpha"]
["Diethylhexyl Phthalate","PPAR alpha",1,0,1,1,"PPARA","18403868",2008,"Different mechanisms of DEHP-induced hepatocellular adenoma tumorigenesis in wild-type and Ppar alpha-null mice.","18403868","Diethylhexyl Phthalate","PPAR alpha"]
["Diethylhexyl Phthalate","PPAR alpha",1,0,1,0,"PPARA","19428328",2009,"Di-(2-ethylhexyl)-phthalate (DEHP) activates the constitutive androstane receptor (CAR): a novel signalling pathway sensitive to phthalates.","19428328","Diethylhexyl Phthalate","PPAR alpha"]
["Diethylhexyl Phthalate","PPAR alpha",1,0,1,1,"PPARA","18829104",2008,"Maternal di-(2-ethylhexyl)-phthalate exposure influences essential fatty acid homeostasis in rat placenta.","18829104","Diethylhexyl Phthalate","PPAR alpha"]
["Diethylhexyl Phthalate","PPAR alpha",1,0,1,0,"PPARA","17462839",2007,"The adjuvant effect of di-(2-ethylhexyl) phthalate is mediated through a PPARalpha-independent mechanism.","17462839","Diethylhexyl Phthalate","PPAR alpha"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L580,L580)","v":"Diethylhexyl Phthalate"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M580,M580)","v":"PPAR alpha"},1,0,1,1,"PPARA",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K580,K580)","v":"18403868"},2008,"Different mechanisms of DEHP-induced hepatocellular adenoma tumorigenesis in wild-type and Ppar alpha-null mice.","18403868","Diethylhexyl Phthalate","PPAR alpha"]
["Diethylhexyl Phthalate","PPAR alpha",1,0,1,0,"PPARA","19428328",2009,"Di-(2-ethylhexyl)-phthalate (DEHP) activates the constitutive androstane receptor (CAR): a novel signalling pathway sensitive to phthalates.","19428328","Diethylhexyl Phthalate","PPAR alpha"]
["Diethylhexyl Phthalate","PPAR alpha",1,0,1,1,"PPARA","17135395",2007,"Peroxisome proliferator-activated receptor alpha protects against glomerulonephritis induced by long-term exposure to the plasticizer di-(2-ethylhexyl)phthalate.","17135395","Diethylhexyl Phthalate","PPAR alpha"]
["Diethylhexyl Phthalate","PPAR alpha",1,0,1,0,"PPARA","20123631",2010,"To each his own: DEHP yields species-specific metabolic phenotypes.","20123631","Diethylhexyl Phthalate","PPAR alpha"]
["Diethylhexyl Phthalate","PPAR alpha",1,0,1,1,"PPARA","19344669",2009,"Clinically relevant concentrations of di (2-ethylhexyl) phthalate (DEHP) uncouple cardiac syncytium.","19344669","Diethylhexyl Phthalate","PPAR alpha"]
["Diethylhexyl Phthalate","PPAR alpha",1,0,1,1,"PPARA","19938896",2010,"Mono(2-ethylhexyl) phthalate induces both pro- and anti-inflammatory responses in rat alveolar macrophages through crosstalk between p38, the lipoxygenase pathway and PPARalpha.","19938896","Diethylhexyl Phthalate","PPAR alpha"]
["Diethylhexyl Phthalate","PPAR alpha",1,0,1,1,"PPARA","19938896",2010,"Mono(2-ethylhexyl) phthalate induces both pro- and anti-inflammatory responses in rat alveolar macrophages through crosstalk between p38, the lipoxygenase pathway and PPARalpha.","19938896","Diethylhexyl Phthalate","PPAR alpha"]
["Diethylhexyl Phthalate","PPAR alpha",1,0,1,1,"PPARA","19850644",2010,"Characterization of peroxisome proliferator-activated receptor alpha--independent effects of PPARalpha activators in the rodent liver: di-(2-ethylhexyl) phthalate also activates the constitutive-activated receptor.","19850644","Diethylhexyl Phthalate","PPAR alpha"]
["Diethylhexyl Phthalate","PPAR alpha",1,0,1,1,"PPARA","19850644",2010,"Characterization of peroxisome proliferator-activated receptor alpha--independent effects of PPARalpha activators in the rodent liver: di-(2-ethylhexyl) phthalate also activates the constitutive-activated receptor.","19850644","Diethylhexyl Phthalate","PPAR alpha"]
["Diethylhexyl Phthalate","PPAR alpha",1,0,1,1,"PPARA","24811840",2014,"Peroxisome proliferator-activated receptor ? mediates di-(2-ethylhexyl) phthalate transgenerational repression of ovarian Esr1 expression in female mice.","24811840","Diethylhexyl Phthalate","PPAR alpha"]
["Diethylhexyl Phthalate","PPAR alpha",1,0,1,1,"PPARA","24811840",2014,"Peroxisome proliferator-activated receptor ? mediates di-(2-ethylhexyl) phthalate transgenerational repression of ovarian Esr1 expression in female mice.","24811840","Diethylhexyl Phthalate","PPAR alpha"]
["Diethylhexyl Phthalate","PPAR alpha",1,0,1,0,"PPARA","17462839",2007,"The adjuvant effect of di-(2-ethylhexyl) phthalate is mediated through a PPARalpha-independent mechanism.","17462839","Diethylhexyl Phthalate","PPAR alpha"]
["Diethylhexyl Phthalate","PPAR alpha",1,0,1,0,"PPARA","22143055",2012,"Mono-2-ethylhexylphthalate (MEHP) induces TNF-? release and macrophage differentiation through different signalling pathways in RAW264.7 cells.","22143055","Diethylhexyl Phthalate","PPAR alpha"]
["Diethylhexyl Phthalate","PPAR alpha",1,0,1,0,"PPARA","20123618",2010,"The pollutant diethylhexyl phthalate regulates hepatic energy metabolism via species-specific PPARalpha-dependent mechanisms.","20123618","Diethylhexyl Phthalate","PPAR alpha"]
["Diethylhexyl Phthalate","PPAR alpha",1,0,1,0,"PPARA","16937134",2007,"Induction of peroxisome proliferator-activated receptor alpha (PPARalpha)-related enzymes by di(2-ethylhexyl) phthalate (DEHP) treatment in mice and rats, but not marmosets.","16937134","Diethylhexyl Phthalate","PPAR alpha"]
["Diethylhexyl Phthalate","PPAR alpha",1,0,1,0,"PPARA","16326050",2006,"Mono(2-ethylhexyl)phthalate and mono-n-butyl phthalate activation of peroxisome proliferator activated-receptors alpha and gamma in breast.","16326050","Diethylhexyl Phthalate","PPAR alpha"]
["Diethylhexyl Phthalate","PPAR alpha",1,0,1,0,"PPARA","16937134",2007,"Induction of peroxisome proliferator-activated receptor alpha (PPARalpha)-related enzymes by di(2-ethylhexyl) phthalate (DEHP) treatment in mice and rats, but not marmosets.","16937134","Diethylhexyl Phthalate","PPAR alpha"]
["Diethylhexyl Phthalate","PPAR alpha",1,0,1,1,"PPARA","23619606",2013,"Exposure to DEHP decreased four fatty acid levels in plasma of prepartum mice.","23619606","Diethylhexyl Phthalate","PPAR alpha"]
["Diethylhexyl Phthalate","PPAR alpha",1,0,1,1,"PPARA","23619606",2013,"Exposure to DEHP decreased four fatty acid levels in plasma of prepartum mice.","23619606","Diethylhexyl Phthalate","PPAR alpha"]
["Diethylhexyl Phthalate","PPAR alpha",1,0,1,1,"PPARA","22672789",2012,"Phthalate exposure changes the metabolic profile of cardiac muscle cells.","22672789","Diethylhexyl Phthalate","PPAR alpha"]
["Diethylhexyl Phthalate","PPAR alpha",1,0,1,0,"PPARA","22143055",2012,"Mono-2-ethylhexylphthalate (MEHP) induces TNF-? release and macrophage differentiation through different signalling pathways in RAW264.7 cells.","22143055","Diethylhexyl Phthalate","PPAR alpha"]
["Diethylhexyl Phthalate","PPAR alpha",1,0,1,1,"PPARA","22672789",2012,"Phthalate exposure changes the metabolic profile of cardiac muscle cells.","22672789","Diethylhexyl Phthalate","PPAR alpha"]
["Diethylhexyl Phthalate","PPAR alpha",1,0,1,0,"PPARA","16326050",2006,"Mono(2-ethylhexyl)phthalate and mono-n-butyl phthalate activation of peroxisome proliferator activated-receptors alpha and gamma in breast.","16326050","Diethylhexyl Phthalate","PPAR alpha"]
["Diethylhexyl Phthalate","PPAR gamma",1,0,1,1,"PPARG","17654247",2007,"Di(2-ethylhexyl) phthalate induces apoptosis through peroxisome proliferators-activated receptor-gamma and ERK 1/2 activation in testis of Sprague-Dawley rats.","17654247","Diethylhexyl Phthalate","PPAR gamma"]
["Diethylhexyl Phthalate","PPAR gamma",1,0,1,0,"PPARG","22017230",2011,"Combined transcriptomic-(1)H NMR metabonomic study reveals that monoethylhexyl phthalate stimulates adipogenesis and glyceroneogenesis in human adipocytes.","22017230","Diethylhexyl Phthalate","PPAR gamma"]
["Diethylhexyl Phthalate","PPAR gamma",1,0,1,1,"PPARG","17468099",2007,"The endocrine disruptor monoethyl-hexyl-phthalate is a selective peroxisome proliferator-activated receptor gamma modulator that promotes adipogenesis.","17468099","Diethylhexyl Phthalate","PPAR gamma"]
["Diethylhexyl Phthalate","PPAR gamma",1,0,1,1,"PPARG","17654247",2007,"Di(2-ethylhexyl) phthalate induces apoptosis through peroxisome proliferators-activated receptor-gamma and ERK 1/2 activation in testis of Sprague-Dawley rats.","17654247","Diethylhexyl Phthalate","PPAR gamma"]
["Diethylhexyl Phthalate","PPAR gamma",1,0,1,1,"PPARG","22279657",2011,"[Effects of di-(2-ethylhexyl) phthalate exposure on reproductive development and PPARs in prepubertal female rats].","22279657","Diethylhexyl Phthalate","PPAR gamma"]
["Diethylhexyl Phthalate","PPAR gamma",1,0,1,0,"PPARG","22143055",2012,"Mono-2-ethylhexylphthalate (MEHP) induces TNF-? release and macrophage differentiation through different signalling pathways in RAW264.7 cells.","22143055","Diethylhexyl Phthalate","PPAR gamma"]
["Diethylhexyl Phthalate","PPAR gamma",1,0,1,0,"PPARG","16326050",2006,"Mono(2-ethylhexyl)phthalate and mono-n-butyl phthalate activation of peroxisome proliferator activated-receptors alpha and gamma in breast.","16326050","Diethylhexyl Phthalate","PPAR gamma"]
["Diethylhexyl Phthalate","PPAR gamma",1,0,1,1,"PPARG","17468099",2007,"The endocrine disruptor monoethyl-hexyl-phthalate is a selective peroxisome proliferator-activated receptor gamma modulator that promotes adipogenesis.","17468099","Diethylhexyl Phthalate","PPAR gamma"]
["Diethylhexyl Phthalate","PPAR gamma",1,0,1,0,"PPARG","22143055",2012,"Mono-2-ethylhexylphthalate (MEHP) induces TNF-? release and macrophage differentiation through different signalling pathways in RAW264.7 cells.","22143055","Diethylhexyl Phthalate","PPAR gamma"]
["Diethylhexyl Phthalate","PPAR gamma",1,0,1,0,"PPARG","22017230",2011,"Combined transcriptomic-(1)H NMR metabonomic study reveals that monoethylhexyl phthalate stimulates adipogenesis and glyceroneogenesis in human adipocytes.","22017230","Diethylhexyl Phthalate","PPAR gamma"]
["Diethylhexyl Phthalate","PPAR gamma",1,0,1,1,"PPARG","18829104",2008,"Maternal di-(2-ethylhexyl)-phthalate exposure influences essential fatty acid homeostasis in rat placenta.","18829104","Diethylhexyl Phthalate","PPAR gamma"]
["Diethylhexyl Phthalate","PPAR gamma",1,0,1,0,"PPARG","16326050",2006,"Mono(2-ethylhexyl)phthalate and mono-n-butyl phthalate activation of peroxisome proliferator activated-receptors alpha and gamma in breast.","16326050","Diethylhexyl Phthalate","PPAR gamma"]
["Diethylhexyl Phthalate","PPAR gamma",1,0,1,1,"PPARG","21856391",2011,"Activation of Trim17 by PPAR? is involved in di(2-ethylhexyl) phthalate (DEHP)-induced apoptosis on Neuro-2a cells.","21856391","Diethylhexyl Phthalate","PPAR gamma"]
["Diethylhexyl Phthalate","PPAR gamma",1,0,1,1,"PPARG","21856391",2011,"Activation of Trim17 by PPAR? is involved in di(2-ethylhexyl) phthalate (DEHP)-induced apoptosis on Neuro-2a cells.","21856391","Diethylhexyl Phthalate","PPAR gamma"]
["Diethylhexyl Phthalate","PPAR gamma",1,0,1,1,"PPARG","18829104",2008,"Maternal di-(2-ethylhexyl)-phthalate exposure influences essential fatty acid homeostasis in rat placenta.","18829104","Diethylhexyl Phthalate","PPAR gamma"]
["Diethylhexyl Phthalate","PPAR gamma",1,0,1,1,"PPARG","22279657",2011,"[Effects of di-(2-ethylhexyl) phthalate exposure on reproductive development and PPARs in prepubertal female rats].","22279657","Diethylhexyl Phthalate","PPAR gamma"]
["Diethylstilbestrol","pregnane X receptor",1,1,1,1,"NR1I2","23384967",2013,"Comparative analysis of human CYP3A4 and rat CYP3A1 induction and relevant gene expression by bisphenol A and diethylstilbestrol: implications for toxicity testing paradigms.","23384967","Diethylstilbestrol","pregnane X receptor"]
["Diethylstilbestrol","Receptors, Glucocorticoid",1,1,1,1,"NR3C1","3991183",1985,"[Delayed effects of fetal and perinatal steroid therapy at receptor levels (considerations on results of possible iatrogenic damage)].","3991183","Diethylstilbestrol","Receptors, Glucocorticoid"]
["Diethylstilbestrol","Receptors, Glucocorticoid",1,1,1,0,"NR3C1","8255389",1993,"Restoration by bromocriptine of glucocorticoid receptors and glucocorticoid negative feedback on prolactin secretion in estrogen-induced pituitary tumors.","8255389","Diethylstilbestrol","Receptors, Glucocorticoid"]
["Diethylstilbestrol","Receptors, Glucocorticoid",1,1,1,0,"NR3C1","6632000",1983,"Steroid-hormone-binding proteins in normal and neoplastic mammary tissues from C3H mice fed diethylstilbestrol.","6632000","Diethylstilbestrol","Receptors, Glucocorticoid"]
["Diethylstilbestrol","PPAR gamma",1,1,1,0,"PPARG","22679223",2012,"Neonatal diethylstilbestrol exposure alters the metabolic profile of uterine epithelial cells.","22679223","Diethylstilbestrol","PPAR gamma"]
["Diethylstilbestrol","PPAR gamma",1,1,1,1,"PPARG","23426703",2013,"Cholesterol homeostasis in the ovaries of neonatally diethylstilbestrol-treated mice.","23426703","Diethylstilbestrol","PPAR gamma"]
["diisobutyl phthalate","PPAR alpha",1,1,0,0,"PPARA","18602967",2008,"Impact of diisobutyl phthalate and other PPAR agonists on steroidogenesis and plasma insulin and leptin levels in fetal rats.","18602967","diisobutyl phthalate","PPAR alpha"]
["diisobutyl phthalate","PPAR gamma",1,1,0,0,"PPARG","18602967",2008,"Impact of diisobutyl phthalate and other PPAR agonists on steroidogenesis and plasma insulin and leptin levels in fetal rats.","18602967","diisobutyl phthalate","PPAR gamma"]
["Dimethylnitrosamine","Receptors, Glucocorticoid",0,0,1,1,"NR3C1","8079364",1994,"Role of hydrocortisone in dimethylnitrosamine-induced suppression of antibody response in the mixed culture of murine hepatocytes and splenocytes.","8079364","Dimethylnitrosamine","Receptors, Glucocorticoid"]
["Dimethylnitrosamine","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8097092",1993,"In vivo inhibition of glucocorticoid-inducible gene expression by dimethylnitrosamine in rat liver.","8097092","Dimethylnitrosamine","Receptors, Glucocorticoid"]
["dodecylbenzenesulfonic acid","PPAR gamma",0,0,1,0,"PPARG","24025786",2013,"Sodium dodecyl sulfate and sodium dodecyl benzenesulfonate are ligands for peroxisome proliferator-activated receptor ?.","24025786","dodecylbenzenesulfonic acid","PPAR gamma"]
["Endosulfan","pregnane X receptor",1,0,1,1,"NR1I2","20361990",2010,"Endosulfan induces CYP2B6 and CYP3A4 by activating the pregnane X receptor.","20361990","Endosulfan","pregnane X receptor"]
["Endosulfan","constitutive androstane receptor",1,0,1,1,"NR1I3","20361990",2010,"Endosulfan induces CYP2B6 and CYP3A4 by activating the pregnane X receptor.","20361990","Endosulfan","constitutive androstane receptor"]
["Estradiol","farnesoid X-activated receptor",1,0,1,0,"NR1H4","12842887",2003,"Estrogen receptor alpha regulates expression of the orphan receptor small heterodimer partner.","12842887","Estradiol","farnesoid X-activated receptor"]
["Estradiol","pregnane X receptor",1,0,1,0,"NR1I2","19011999",2008,"Augmentation of estrogen receptor-mediated transcription by steroid and xenobiotic receptor.","19011999","Estradiol","pregnane X receptor"]
["Estradiol","pregnane X receptor",1,0,1,0,"NR1I2","17327420",2007,"Crystal structure of the pregnane X receptor-estradiol complex provides insights into endobiotic recognition.","17327420","Estradiol","pregnane X receptor"]
["Estradiol","constitutive androstane receptor",1,0,1,0,"NR1I3","22484313",2012,"Estradiol induces cytochrome P450 2B6 expression at high concentrations: implication in estrogen-mediated gene regulation in pregnancy.","22484313","Estradiol","constitutive androstane receptor"]
["Estradiol","constitutive androstane receptor",1,0,1,0,"NR1I3","18618240",2009,"Expression of coxsackie-adenovirus receptor is related to estrogen sensitivity in breast cancer.","18618240","Estradiol","constitutive androstane receptor"]
["Estradiol","constitutive androstane receptor",1,0,1,0,"NR1I3","21768169",2011,"Potential role of estradiol and progesterone in insulin resistance through constitutive androstane receptor.","21768169","Estradiol","constitutive androstane receptor"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","1505471",1992,"Sexual dimorphism in regulation of type II corticosteroid receptor immunoreactivity in the rat hippocampus.","1505471","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","1871098",1991,"[Changes in plasma levels of corticosterone, testosterone and estradiol and their receptors in the lung cytosol in experimental fibrosing process in the lungs].","1871098","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","12193391",2002,"Influence of estradiol on NADPH diaphorase/neuronal nitric oxide synthase activity and colocalization with progesterone or type II glucocorticoid receptors in ovine hypothalamus.","12193391","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","1562533",1992,"Demonstration of steroid hormone receptors and steroid action in primary cultures of rat glial cells.","1562533","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","23296098",2013,"Endocrine disrupting effects of ochratoxin A at the level of nuclear receptor activation and steroidogenesis.","23296098","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","17035596",2007,"Estrogen receptor antagonist fulvestrant (ICI 182,780) inhibits the anti-inflammatory effect of glucocorticoids.","17035596","Estradiol","Receptors, Glucocorticoid"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L644,L644)","v":"Estradiol"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M644,M644)","v":"Receptors, Glucocorticoid"},1,0,1,0,"NR3C1",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K644,K644)","v":"11914122"},2002,"Effect of adrenocorticotrophic hormone on the development of oestrogen-induced changes and hyperplasia formation in the mouse uterus.","11914122","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","20734254",2010,"Inducible gene expression systems for plants.","20734254","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","14724131",2004,"Acquisition of luteolytic capacity: changes in prostaglandin F2alpha regulation of steroid hormone receptors and estradiol biosynthesis in pig corpora lutea.","14724131","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","21357268",2011,"Cross talk between glucocorticoid and estrogen receptors occurs at a subset of proinflammatory genes.","21357268","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","21336598",2012,"Glucocorticoid receptor activity discriminates between progesterone and medroxyprogesterone acetate effects in breast cells.","21336598","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","3366990",1988,"[In vitro binding of purified glucocorticoid- and estrogen-receptor complexes in the rat liver with homologous chromatin of different levels of molecular organization].","3366990","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","19096000",2009,"Certain progestins prevent the enhancing effect of 17beta-estradiol on NO-mediated inhibition of platelet aggregation by endothelial cells.","19096000","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","3595529",1987,"Multiple hormones regulate angiotensinogen messenger ribonucleic acid levels in a rat hepatoma cell line.","3595529","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","23541378",2013,"Estradiol stimulates an anti-translocation expression pattern of glucocorticoid co-regulators in a hippocampal cell model.","23541378","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","1562550",1992,"The estradiol induction of the microsomal low-affinity glucocorticoid binding sites (LAGS) in the male rat liver is independent of the endocrine status.","1562550","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","19318326",2009,"[Endocrine factors influencing melanoma progression].","19318326","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","19130315",2009,"Modulatory role of locus coeruleus and estradiol on the stress response of female rats.","19130315","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","12553866",2003,"Effects of cortisol and oestradiol on hepatic 11beta-hydroxysteroid dehydrogenase type 1 and glucocorticoid receptor proteins in late-gestation sheep fetus.","12553866","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","3174650",1988,"Synergistic action of glucocorticoid and estradiol responsive elements.","3174650","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","3390864",1988,"The hormone-binding domains of the estrogen and glucocorticoid receptors contain an inducible transcription activation function.","3390864","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","11861974",2002,"A novel cell line, MDA-kb2, that stably expresses an androgen- and glucocorticoid-responsive reporter for the detection of hormone receptor agonists and antagonists.","11861974","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","3274898",1987,"Estrogen-induced decrease of glucocorticoid receptor messenger ribonucleic acid concentration in rat anterior pituitary gland.","3274898","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","14519664",2003,"Dexamethasone blocks the rapid biological effects of 17beta-estradiol in the rat uterus without antagonizing its global genomic actions.","14519664","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","4007026",1985,"Tamoxifen alone or in combination with estradiol-17 beta inhibits the growth and malignant transformation of hepatic hyperplastic nodules.","4007026","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","15725946",2005,"Estrogen protects cardiac myogenic (H9c2) rat cells against lethal heat shock-induced cell injury: modulation of estrogen receptor alpha, glucocorticoid receptors, heat shock protein 70, and iNOS.","15725946","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","1458342",1992,"Characteristics of steroid hormone receptors in cultured MC3T3-E1 osteoblastic cells and effect of steroid hormones on cell proliferation.","1458342","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","491603",1979,"Incorporation of steroid hormones in nuclei of different ploidy and different phases of the cell cycle.","491603","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","11509008",2001,"Inhibitory effect of physiological concentrations of cortisol but not estradiol on interleukin (IL)-6 production by human osteoblast-like cell lines with different constitutive IL-6 expression.","11509008","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","22330",1977,"Paradoxical dissociation between gluconeogenic effects and glucocorticoid-receptor binding by gonadal steroids.","22330","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","1324155",1992,"Chronic estrogen-induced alterations in adrenocorticotropin and corticosterone secretion, and glucocorticoid receptor-mediated functions in female rats.","1324155","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","10342828",1999,"Suppression of ligand-dependent estrogen receptor activity by bone-resorbing cytokines in human osteoblasts.","10342828","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","4007011",1985,"Tamoxifen alone or in combination with estradiol-17 beta inhibits the growth and malignant transformation of hepatic hyperplastic nodules.","4007011","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","1995287",1991,"Estrogen-inducible progesterone receptor in primary cultures of rat glial cells.","1995287","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","18794126",2008,"Glucocorticoids antagonize estrogens by glucocorticoid receptor-mediated activation of estrogen sulfotransferase.","18794126","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","16855144",2006,"Effects of testosterone, 17beta-estradiol, and downstream estrogens on cytokine secretion from human leukocytes in the presence and absence of cortisol.","16855144","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","3025750",1987,"Oestradiol induction of a glucocorticoid-responsive gene by a chimaeric receptor.","3025750","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","11444431",2001,"Effects of cortisol and estradiol on pituitary expression of proopiomelanocortin, prohormone convertase-1, prohormone convertase-2, and glucocorticoid receptor mRNA in fetal sheep.","11444431","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","19273191",2009,"2-Methoxyestradiol mediated signaling network in pancreatic cancer.","19273191","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","11358672",2001,"Estradiol inhibits glucocorticoid receptor expression and induces glucocorticoid resistance in MCF-7 human breast cancer cells.","11358672","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","19179642",2009,"Interference of progestins with endothelial actions of estrogens: a matter of glucocorticoid action or deprivation?","19179642","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","19941958",2010,"Mechanism of action of bolandiol (19-nortestosterone-3beta,17beta-diol), a unique anabolic steroid with androgenic, estrogenic, and progestational activities.","19941958","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","17307208",2007,"Regulation of tissue beta-adrenergic, glucocorticoid and androgen receptors induced by repeated exposure to growth promoters in male veal calves.","17307208","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","16515662",2006,"Changes in lymphocyte glucocorticoid and beta-adrenergic receptors in veal calves treated with clenbuterol and steroid hormones for growth-promoting purposes.","16515662","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","2046482",1991,"Estrogens up-regulate type I and type II glucocorticoid receptors in brain regions from ovariectomized rats.","2046482","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,1,"NR3C1","12593897",2003,"Expression of estrogen receptor-alpha, glucocorticoid receptor, beta-catenin and glycogen synthase kinase-3beta in the uterus of mice following long-term treatment with estrogen and glucocorticoid hormones.","12593897","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","7706984",1995,"The influence of ovarian steroids on hypothalamic-pituitary-adrenal regulation in the female rat.","7706984","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","6708516",1984,"Anti-steroid action in cultured L-929 mouse fibroblasts.","6708516","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","6840677",1983,"Evidence for the hormone dependency of hepatic hyperplastic nodules: inhibition of malignant transformation after exogenous 17 beta-estradiol and tamoxifen.","6840677","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","6704206",1984,"Peroxidase activity as a marker for estrogen action in rat uteri and human mammary carcinomas.","6704206","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","8429760",1993,"Estradiol increases glucocorticoid binding and glucocorticoid induction of ornithine decarboxylase in the rat spinal cord.","8429760","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","7969768",1994,"Fast glucocorticoid feedback inhibition of ACTH secretion in the ovariectomized rat: effect of chronic estrogen and progesterone.","7969768","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","8847961",1995,"Estradiol abolishes autologous down regulation of glucocorticoid receptors in brain.","8847961","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","6106733",1980,"Hormonal control of tyrosine aminotransferase, prolactin, and growth hormone induction in somatic cell hybrids.","6106733","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","7101825",1982,"[Content of 17 beta éstradiol, progesterone and glucocorticoid receptors in patients with benign breast diseases].","7101825","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","6171467",1981,"Immunoprecipitation assay of alpha-fetoprotein synthesis by cultured mouse hepatoma cells treated with estrogens and glucocorticoids.","6171467","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","7372669",1980,"Differential hormonal control of a messenger RNA in two tissues Uteroglobin mRNA in the lung and the endometrium.","7372669","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","9559318",1998,"Imprinting of thymic glucocorticoid receptor and uterine estrogen receptor by a synthetic steroid hormone at different times after birth.","9559318","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","8499337",1993,"Progesterone and dexamethasone inhibition of estrogen-induced synthesis of DNA and complement in rat uterine epithelium: effects of antiprogesterone compounds.","8499337","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","9986926",1999,"Estrogens normalize the hypothalamic-pituitary-adrenal axis response to stress and increase glucocorticoid receptor immuno-reactivity in hippocampus of aging male rats.","9986926","Estradiol","Receptors, Glucocorticoid"]
["Estradiol","Nuclear Receptor Subfamily 4, Group A, Member 2",1,0,1,0,"NR4A2","25048945",2014,"Effect of 17?-estradiol on striatal dopaminergic transmission induced by permethrin in early childhood rats.","25048945","Estradiol","Nuclear Receptor Subfamily 4, Group A, Member 2"]
["Estradiol","PPAR alpha",1,0,1,0,"PPARA","15964169",2005,"Modulation of peroxisome proliferator-activated receptors (PPARs) by PPAR(alpha)- and PPAR(gamma)-specific ligands and by 17beta-estradiol in isolated zebrafish hepatocytes.","15964169","Estradiol","PPAR alpha"]
["Estradiol","PPAR alpha",1,0,1,0,"PPARA","19755663",2009,"PPAR-alpha contributes to the anti-inflammatory activity of 17beta-estradiol.","19755663","Estradiol","PPAR alpha"]
["Estradiol","PPAR alpha",1,0,1,0,"PPARA","17557980",2007,"Inhibition of the actions of peroxisome proliferator-activated receptor alpha on obesity by estrogen.","17557980","Estradiol","PPAR alpha"]
["Estradiol","PPAR alpha",1,0,1,0,"PPARA","18255343",2008,"Inhibition of vascular inflammation by dehydroepiandrosterone sulfate in human aortic endothelial cells: roles of PPARalpha and NF-kappaB.","18255343","Estradiol","PPAR alpha"]
["Estradiol","PPAR alpha",1,0,1,0,"PPARA","22386939",2012,"Estrogen therapy attenuates adiposity markers in spontaneously hypertensive rats.","22386939","Estradiol","PPAR alpha"]
["Estradiol","PPAR gamma",1,0,1,0,"PPARG","19333775",2009,"Effect of estrogens on bone marrow adipogenesis  and Sirt1 in aging C57BL/6J mice.","19333775","Estradiol","PPAR gamma"]
["Estradiol","PPAR gamma",1,0,1,0,"PPARG","20665707",2011,"Role of PPAR? in the salutary effects of 17?-estradiol on Kupffer cell cytokine production following trauma-hemorrhage.","20665707","Estradiol","PPAR gamma"]
["Estradiol","PPAR gamma",1,0,1,0,"PPARG","21293475",2011,"17?-Estradiol inhibition of PPAR?-induced adipogenesis and adipocyte-specific gene expression.","21293475","Estradiol","PPAR gamma"]
["Estradiol","PPAR gamma",1,0,1,0,"PPARG","20064783",2010,"Peroxisome proliferator-activated receptor-gamma mediates bisphenol A inhibition of FSH-stimulated IGF-1, aromatase, and estradiol in human granulosa cells.","20064783","Estradiol","PPAR gamma"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L708,L708)","v":"Estradiol"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M708,M708)","v":"PPAR gamma"},1,0,1,0,"PPARG",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K708,K708)","v":"18296905"},2008,"Comparative effects of 17beta-estradiol and phytoestrogens in the regulation of endometrial functions in the rodent uterus.","18296905","Estradiol","PPAR gamma"]
["Estradiol","PPAR gamma",1,0,1,0,"PPARG","22402114",2012,"Retroperitoneal white adipose tissue mitochondrial function and adiponectin expression in response to ovariectomy and 17?-estradiol replacement.","22402114","Estradiol","PPAR gamma"]
["Estradiol","PPAR gamma",1,0,1,0,"PPARG","18835379",2008,"Troglitazone enhances tamoxifen-induced growth inhibitory activity of MCF-7 cells.","18835379","Estradiol","PPAR gamma"]
["Estradiol","PPAR gamma",1,0,1,0,"PPARG","18222430",2008,"Key lipogenic gene expression can be decreased by estrogen in human adipose tissue.","18222430","Estradiol","PPAR gamma"]
["Estradiol","PPAR gamma",1,0,1,0,"PPARG","15964169",2005,"Modulation of peroxisome proliferator-activated receptors (PPARs) by PPAR(alpha)- and PPAR(gamma)-specific ligands and by 17beta-estradiol in isolated zebrafish hepatocytes.","15964169","Estradiol","PPAR gamma"]
["Estradiol","PPAR gamma",1,0,1,0,"PPARG","22386939",2012,"Estrogen therapy attenuates adiposity markers in spontaneously hypertensive rats.","22386939","Estradiol","PPAR gamma"]
["Estradiol","PPAR gamma",1,0,1,0,"PPARG","17363578",2007,"15-deoxy-Delta12,14-prostaglandin J2 inhibits transcriptional activity of estrogen receptor-alpha via covalent modification of DNA-binding domain.","17363578","Estradiol","PPAR gamma"]
["Estradiol","PPAR gamma",1,0,1,0,"PPARG","15750262",2004,"Genistein inhibits expressions of NADPH oxidase p22phox and angiotensin II type 1 receptor in aortic endothelial cells from stroke-prone spontaneously hypertensive rats.","15750262","Estradiol","PPAR gamma"]
["Estradiol","PPAR gamma",1,0,1,0,"PPARG","20198337",2010,"17beta-estradiol induces up-regulation of PTEN and PPARgamma in leiomyoma cells, but not in normal cells.","20198337","Estradiol","PPAR gamma"]
["Estradiol","PPAR gamma",1,0,1,0,"PPARG","24377602",2013,"Influence of 17?-estradiol on 15-deoxy-?12,14 prostaglandin J2 -induced apoptosis in MCF-7 and MDA-MB-231 cells.","24377602","Estradiol","PPAR gamma"]
["Estradiol","PPAR gamma",1,0,1,0,"PPARG","22538444",2012,"Drug-targeted inhibition of peroxisome proliferator-activated receptor-gamma enhances the chemopreventive effect of anti-estrogen therapy.","22538444","Estradiol","PPAR gamma"]
["Estradiol","PPAR gamma",1,0,1,0,"PPARG","19948157",2010,"Estradiol or genistein prevent Alzheimer's disease-associated inflammation correlating with an increase PPAR gamma expression in cultured astrocytes.","19948157","Estradiol","PPAR gamma"]
["Estradiol","PPAR gamma",1,0,1,0,"PPARG","19494505",2009,"Regulation of peroxisome proliferator-activated receptor-gamma expression in human eosinophils by estradiol.","19494505","Estradiol","PPAR gamma"]
["Estradiol","PPAR gamma",1,0,1,0,"PPARG","17879945",2008,"Estrogen prevents cholesteryl ester accumulation in macrophages induced by the HIV protease inhibitor ritonavir.","17879945","Estradiol","PPAR gamma"]
["Estradiol","PPAR gamma",1,0,1,0,"PPARG","23549616",2013,"Upregulation of SIRT1 by 17?-estradiol depends on ubiquitin-proteasome degradation of PPAR-? mediated by NEDD4-1.","23549616","Estradiol","PPAR gamma"]
["Estradiol","retinoic acid receptor alpha",1,0,1,0,"RARA","12193579",2002,"Retinoic acid receptors and retinoids are up-regulated in the developing and adult rat prostate by neonatal estrogen exposure.","12193579","Estradiol","retinoic acid receptor alpha"]
["Estradiol","retinoic acid receptor alpha",1,0,1,0,"RARA","17538076",2007,"Regulation of 17-beta hydroxysteroid dehydrogenase type 2 in human placental endothelial cells.","17538076","Estradiol","retinoic acid receptor alpha"]
["Estradiol","retinoic acid receptor alpha",1,0,1,0,"RARA","9626663",1998,"Estrogen-induced retinoic acid receptor alpha 1 gene expression: role of estrogen receptor-Sp1 complex.","9626663","Estradiol","retinoic acid receptor alpha"]
["Estradiol","retinoic acid receptor alpha",1,0,1,0,"RARA","7585542",1995,"Estradiol regulation of the human retinoic acid receptor alpha gene in human breast carcinoma cells is mediated via an imperfect half-palindromic estrogen response element and Sp1 motifs.","7585542","Estradiol","retinoic acid receptor alpha"]
["Estradiol","retinoic acid receptor gamma",1,0,1,0,"RARG","12193579",2002,"Retinoic acid receptors and retinoids are up-regulated in the developing and adult rat prostate by neonatal estrogen exposure.","12193579","Estradiol","retinoic acid receptor gamma"]
["Estradiol","retinoic acid receptor gamma",1,0,1,0,"RARG","8806431",1996,"Estrogen induces retinoid receptor expression in mouse cervical epithelia.","8806431","Estradiol","retinoic acid receptor gamma"]
["Ethanolamine","PPAR gamma",0,0,1,0,"PPARG","23168911",2013,"Omega-3 PUFA ethanolamides DHEA and EPEA induce autophagy through PPAR? activation in MCF-7 breast cancer cells.","23168911","Ethanolamine","PPAR gamma"]
["Ethinyl Estradiol","farnesoid X-activated receptor",1,0,1,0,"NR1H4","21528642",2011,"Beneficial effects of colchicine on 17alpha-ethynylestradiol-induced cholestasis in rats.","21528642","Ethinyl Estradiol","farnesoid X-activated receptor"]
["Ethinyl Estradiol","constitutive androstane receptor",1,0,1,0,"NR1I3","18973326",2008,"Ligand specificity of constitutive androstane receptor as probed by induced-fit docking and mutagenesis.","18973326","Ethinyl Estradiol","constitutive androstane receptor"]
["Ethinyl Estradiol","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","902371",1977,"Hormonal control of plasma renin substrate; (angiotensinogen).","902371","Ethinyl Estradiol","Receptors, Glucocorticoid"]
["Ethinyl Estradiol","PPAR alpha",1,0,1,1,"PPARA","19729835",2009,"Sumoylated PPARalpha mediates sex-specific gene repression and protects the liver from estrogen-induced toxicity in mice.","19729835","Ethinyl Estradiol","PPAR alpha"]
["ethofenprox","constitutive androstane receptor",0,0,1,1,"NR1I3","22467020",2012,"Liver tumor promoting effect of etofenprox in rats and its possible mechanism of action.","22467020","ethofenprox","constitutive androstane receptor"]
["etridiazol","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8160438",1994,"[Modulation of the glucocorticoid receptor interaction with sodium ethazole].","8160438","etridiazol","Receptors, Glucocorticoid"]
["Fenofibrate","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","18267115",2008,"Peroxisome proliferator-activated receptor alpha agonist-induced down-regulation of hepatic glucocorticoid receptor expression in SD rats.","18267115","Fenofibrate","Receptors, Glucocorticoid"]
["Fenofibrate","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","20193367",2009,"[Agonist-induced down-regulation of hepatic glucocorticoid receptor via peroxisome proliferator-activated receptor in SD rats].","20193367","Fenofibrate","Receptors, Glucocorticoid"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","24022598",2014,"The protective effect of fenofibrate against TNF-?-induced CD40 expression through SIRT1-mediated deacetylation of NF-?B in endothelial cells.","24022598","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","18267115",2008,"Peroxisome proliferator-activated receptor alpha agonist-induced down-regulation of hepatic glucocorticoid receptor expression in SD rats.","18267115","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","22056833",2012,"Peroxisome proliferator-activated receptor-? activation attenuates 3-nitropropionic acid induced behavioral and biochemical alterations in rats: possible neuroprotective mechanisms.","22056833","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","18852043",2008,"PPARalpha ligands inhibit radiation-induced microglial inflammatory responses by negatively regulating NF-kappaB and AP-1 pathways.","18852043","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","18277067",2008,"PPAR-alpha agonist fenofibrate induces renal CYP enzymes and reduces blood pressure and glomerular hypertrophy in Zucker diabetic fatty rats.","18277067","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","19245804",2009,"Fenofibrate ameliorates diabetic and dyslipidemic profiles in KKAy mice partly via down-regulation of 11beta-HSD1, PEPCK and DGAT2. Comparison of PPARalpha, PPARgamma, and liver x receptor agonists.","19245804","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","17343847",2007,"Antinociceptive and antiedematogenic activities of fenofibrate, an agonist of PPAR alpha, and pioglitazone, an agonist of PPAR gamma.","17343847","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","15638786",2005,"Fenofibrate: metabolic and pleiotropic effects.","15638786","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","21751494",2011,"[A dyslipidemia animal model induced by poloxamer 407 in golden hamsters and pilot study on the mechanism].","21751494","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","16009445",2006,"The effect of dual PPAR alpha/gamma stimulation with combination of rosiglitazone and fenofibrate on metabolic parameters in type 2 diabetic patients.","16009445","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","19625768",2009,"Circumventing glucocorticoid-mediated hyperinsulinemia via the activation of PPARalpha.","19625768","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","16013444",2005,"Triglyceridemia and peroxisome proliferator-activated receptor-alpha expression are not connected in fenofibrate-treated pregnant rats.","16013444","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","16762007",2006,"Fenofibrate, a peroxisome proliferator-activated receptor alpha agonist, reduces hepatic steatosis and lipid peroxidation in fatty liver Shionogi mice with hereditary fatty liver.","16762007","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","18358090",2008,"Chronic palmitate exposure inhibits AMPKalpha and decreases glucose-stimulated insulin secretion from beta-cells: modulation by fenofibrate.","18358090","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","22336959",2012,"Rare PPARA variants and extreme response to fenofibrate in the Genetics of Lipid-Lowering Drugs and Diet Network Study.","22336959","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","24122873",2014,"Peroxisome proliferator-activated receptor ? activates human multidrug resistance transporter 3/ATP-binding cassette protein subfamily B4 transcription and increases rat biliary phosphatidylcholine secretion.","24122873","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","18374364",2008,"Fenofibrate prevents orotic acid--induced hepatic steatosis in rats.","18374364","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","19694729",2009,"Atorvastatin and fenofibrate increase apolipoprotein AV and decrease triglycerides by up-regulating peroxisome proliferator-activated receptor-alpha.","19694729","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","19724288",2010,"Fenofibrate improves cerebral blood flow after middle cerebral artery occlusion in mice.","19724288","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","19732852",2009,"Withdrawal of fenofibrate treatment partially abrogates preventive neuroprotection in stroke via loss of vascular protection.","19732852","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","15608561",2004,"Response to micronized fenofibrate treatment is associated with the peroxisome-proliferator-activated receptors alpha G/C intron7 polymorphism in subjects with type 2 diabetes.","15608561","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","15618549",2005,"Regulation of human apoA-I by gemfibrozil and fenofibrate through selective peroxisome proliferator-activated receptor alpha modulation.","15618549","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","15994444",2005,"PPARalpha, but not PPARgamma, activators decrease macrophage-laden atherosclerotic lesions in a nondiabetic mouse model of mixed dyslipidemia.","15994444","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","16413686",2006,"PPARalpha activators may play role for the regression of ventricular hypertrophy in hypertensive and hyperlipidemic patients.","16413686","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","22062085",2012,"Combination treatment with pioglitazone and fenofibrate attenuates pioglitazone-mediated acceleration of bone loss in ovariectomized rats.","22062085","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","21711451",2011,"Effects of Doxorubicin and Fenofibrate on the activities of NADH oxidase and citrate synthase in mice.","21711451","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,1,"PPARA","18253720",2008,"Possible involvement of oxidative stress in fenofibrate-induced hepatocarcinogenesis in rats.","18253720","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","17343853",2007,"Fenofibrate regulates retinal endothelial cell survival through the AMPK signal transduction pathway.","17343853","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","21716269",2011,"Profile of serum bile acids in noncholestatic volunteers: gender-related differences in response to fenofibrate.","21716269","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","16501022",2006,"PPAR-alpha activator fenofibrate increases renal CYP-derived eicosanoid synthesis and improves endothelial dilator function in obese Zucker rats.","16501022","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","16132896",2005,"Pretreatment with peroxysome proliferator-activated receptor alpha agonist fenofibrate protects endothelium in rabbit Escherichia coli endotoxin-induced shock.","16132896","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","22076434",2012,"High-fat diet-induced renal cell apoptosis and oxidative stress in spontaneously hypertensive rat are ameliorated by fenofibrate through the PPAR?-FoxO3a-PGC-1? pathway.","22076434","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","19801103",2009,"The PPARalpha agonist fenofibrate preserves hippocampal neurogenesis and inhibits microglial activation after whole-brain irradiation.","19801103","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","19593819",2009,"Fenofibrate differentially regulates plasminogen activator inhibitor-1 gene expression via adenosine monophosphate-activated protein kinase-dependent induction of orphan nuclear receptor small heterodimer partner.","19593819","Fenofibrate","PPAR alpha"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L772,L772)","v":"Fenofibrate"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M772,M772)","v":"PPAR alpha"},0,0,1,0,"PPARA",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K772,K772)","v":"22280018"},2013,"Coronary flow velocity reserve is improved by PPAR-? agonist fenofibrate in patients with hypertriglyceridemia.","22280018","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","19576184",2009,"PPARalpha activator fenofibrate modulates angiotensin II-induced inflammatory responses in vascular smooth muscle cells via the TLR4-dependent signaling pathway.","19576184","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","19018684",2008,"Fenofibrate: treatment of hyperlipidemia and beyond.","19018684","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","18199835",2008,"PPARalpha agonist fenofibrate suppresses tumor growth through direct and indirect angiogenesis inhibition.","18199835","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","16087294",2005,"Fenofibrate, a peroxisome proliferator-activated receptor alpha agonist, exerts neuroprotective effects in traumatic brain injury.","16087294","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","18198986",2009,"Serum adipocyte fatty acid binding protein levels in patients with type 2 diabetes mellitus and obesity: the influence of fenofibrate treatment.","18198986","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","24398933",2014,"Effects of the PPAR-? agonist fenofibrate on acute and short-term consequences of brain ischemia.","24398933","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","15685545",2005,"Impaired expression of the peroxisome proliferator-activated receptor alpha during hepatitis C virus infection.","15685545","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","18852694",2008,"Activation of peroxisome proliferator-activated receptor-alpha in mice induces expression of the hepatic low-density lipoprotein receptor.","18852694","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","24292381",2013,"Fibrates reduce triacylglycerol content by upregulating adipose triglyceride lipase in the liver of rats.","24292381","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","24511666",2013,"Effectiveness of fenofibrate in comparison to bezafibrate for patients with asymptomatic primary biliary cirrhosis.","24511666","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","24397438",2014,"The peroxisomal proliferator-activated receptor (PPAR) ? agonist, fenofibrate, prevents fractionated whole-brain irradiation-induced cognitive impairment.","24397438","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","16525649",2006,"Effects of PPAR and RXR ligands in semaphorin 6B gene expression of human MCF-7 breast cancer cells.","16525649","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","24392081",2014,"Therapeutic effects of fenofibrate on diabetic peripheral neuropathy by improving endothelial and neural survival in db/db mice.","24392081","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","15669179",2004,"Effect of peroxisome proliferator-activated receptor activators on tumor necrosis factor-alpha expression in neonatal rat cardiac myocytes.","15669179","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","24389487",2014,"A simple and sensitive method for the determination of fibric acids in the liver by liquid chromatography.","24389487","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","17421100",2007,"Sepsis-induced myocardial depression: where is the missing link?","17421100","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,1,"PPARA","19929038",2009,"Fenofibric acid: in combination therapy in the treatment of mixed dyslipidemia.","19929038","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","17438340",2007,"Diabetes or peroxisome proliferator-activated receptor alpha agonist increases mitochondrial thioesterase I activity in heart.","17438340","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","15917863",2005,"Fenofibrate prevents Rosiglitazone-induced body weight gain in ob/ob mice.","15917863","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","19175377",2009,"Effects of cevoglitazar, a dual PPARalpha/gamma agonist, on ectopic fat deposition in fatty Zucker rats.","19175377","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","19801551",2009,"Fenofibrate simultaneously induces hepatic fatty acid oxidation, synthesis, and elongation in mice.","19801551","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","19814866",2009,"Comparative study between the effect of the peroxisome proliferator activated receptor-alpha ligands fenofibrate and n-3 polyunsaturated fatty acids on activation of 5'-AMP-activated protein kinase-alpha1 in high-fat fed rats.","19814866","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","24130796",2013,"Fenofibrate attenuated glucose-induced mesangial cells proliferation and extracellular matrix synthesis via PI3K/AKT and ERK1/2.","24130796","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","16442496",2006,"Fenofibrate activates AMPK and increases eNOS phosphorylation in HUVEC.","16442496","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","24140572",2013,"Fenofibrate A peroxisome proliferator activated receptor-? agonist treatment ameliorates Concanavalin A-induced hepatitis in rats.","24140572","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","16806263",2006,"Attenuation of cardiac dysfunction by a PPAR-alpha agonist is associated with down-regulation of redox-regulated transcription factors.","16806263","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","19553925",2009,"Nonalcoholic hepatic steatosis in Zucker diabetic rats: spontaneous evolution and effects of metformin and fenofibrate.","19553925","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","17353509",2007,"Peroxisome proliferator-activated receptor alpha-independent actions of fenofibrate exacerbates left ventricular dilation and fibrosis in chronic pressure overload.","17353509","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","22226866",2012,"Role of the PPAR-? agonist fenofibrate in severe pediatric burn.","22226866","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,1,"PPARA","25035112",2014,"PPAR?-dependent exacerbation of experimental colitis by the hypolipidemic drug fenofibrate.","25035112","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","19179882",2009,"Alteration of canalicular transporters in a mouse model of total parenteral nutrition.","19179882","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","16772490",2006,"Fenofibrate lowers lipid parameters in obese dogs.","16772490","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","19024111",2008,"Peroxisome proliferator-activated receptor alpha agonist attenuates oxidized-low density lipoprotein induced immune maturation of human monocyte-derived dendritic cells.","19024111","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","24211584",2013,"Fenofibrate, a peroxisome proliferator-activated receptor ? ligand, prevents abnormal liver function induced by a fasting-refeeding process.","24211584","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","18356826",2008,"Effect of peroxisome proliferator-activated receptor-alpha ligands in the interaction between adipocytes and macrophages in obese adipose tissue.","18356826","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,1,"PPARA","22301950",2012,"The PPAR? agonists fenofibrate and CP-778875 cause increased ?-oxidation, leading to oxidative injury in skeletal and cardiac muscle in the rat.","22301950","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,1,"PPARA","16437706",2005,"Fenofibrate-induced liver injury.","16437706","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,1,"PPARA","17457016",2007,"Fenofibrate increases high molecular weight adiponectin in subjects with hypertriglyceridemia.","17457016","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","15936324",2005,"Effects of fenofibrate on inflammatory cytokines and blood pressure in patients with hypertriglyceridemia.","15936324","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","20061429",2010,"Fenofibrate reduces systemic inflammation markers independent of its effects on lipid and glucose metabolism in patients with the metabolic syndrome.","20061429","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","17356236",2006,"Effect of peroxisome proliferator-activated receptor alpha ligand fenofibrate on K(v) channels in the insulin-secreting cell line HIT-T15.","17356236","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","17215446",2007,"Chronic activation of peroxisome proliferator-activated receptor-alpha with fenofibrate prevents alterations in cardiac metabolic phenotype without changing the onset of decompensation in pacing-induced heart failure.","17215446","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","16713430",2006,"Effects of fenofibrate on lipid metabolism in adipose tissue of rats.","16713430","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","20661551",2011,"Fetal alcohol-induced hyperactivity is reversed by treatment with the PPAR? agonist fenofibrate in a rat model.","20661551","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","17726195",2007,"Fenofibrate reduces intestinal cholesterol absorption via PPARalpha-dependent modulation of NPC1L1 expression in mouse.","17726195","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","15971419",2005,"Inhibition of NF-kappaB signaling by fenofibrate, a peroxisome proliferator-activated receptor-alpha ligand, presents a therapeutic strategy for rheumatoid arthritis.","15971419","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","16672917",2006,"The PPARalpha ligand fenofibrate: meeting multiple targets in diabetic nephropathy.","16672917","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","16672921",2006,"PPARalpha agonist fenofibrate improves diabetic nephropathy in db/db mice.","16672921","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","21305343",2011,"Effect of preischemic treatment with fenofibrate, a peroxisome proliferator-activated receptor-? ligand, on hepatic ischemia-reperfusion injury in rats.","21305343","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","20614230",2010,"Fenofibrate but not fenofibric acid inhibits 11beta-hydroxysteroid dehydrogenase 1 in C2C12 myotubes.","20614230","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,1,"PPARA","18678301",2008,"Efficacy and safety of a potent and selective peroxisome proliferator activated receptor alpha agonist in subjects with dyslipidemia and type 2 diabetes mellitus.","18678301","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","23518069",2013,"Fenofibrate ameliorates cardiac hypertrophy by activation of peroxisome proliferator-activated receptor-? partly via preventing p65-NF?B binding to NFATc4.","23518069","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","17113579",2007,"Peroxisome proliferator-activated receptor alpha-independent effects of peroxisome proliferators on cysteinyl leukotriene production in mast cells.","17113579","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","22859660",2013,"Effects of fenofibrate, a PPAR-? ligand, on the haemodynamics of glycerol-induced renal failure in rats.","22859660","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","19325138",2009,"Relationships of HDL cholesterol, ApoA-I, and ApoA-II with homocysteine and creatinine in patients with type 2 diabetes treated with fenofibrate.","19325138","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","20663986",2010,"Fenofibrate promotes ischemia-induced revascularization through the adiponectin-dependent pathway.","20663986","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","16675962",2006,"Peroxisome proliferator-activated receptors increase human sebum production.","16675962","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","23628473",2013,"The PPAR? agonist fenofibrate suppresses B-cell lymphoma in mice by modulating lipid metabolism.","23628473","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","16707598",2006,"Peroxisome proliferator-activated receptor alpha activation decreases metastatic potential of melanoma cells in vitro via down-regulation of Akt.","16707598","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","21429719",2012,"Comparison of the effects of n-3 long chain polyunsaturated fatty acids and fenofibrate on markers of inflammation and vascular function, and on the serum lipoprotein profile in overweight and obese subjects.","21429719","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","17245174",2007,"Insulin sensitivity and mitochondrial function are improved in children with burn injury during a randomized controlled trial of fenofibrate.","17245174","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","16325819",2006,"Efficacy of peroxisome proliferative activated receptor (PPAR)-alpha ligands, fenofibrate, on intimal hyperplasia and constrictive remodeling after coronary angioplasty in porcine models.","16325819","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,1,"PPARA","19458390",2009,"Untargeted metabolomic profiling as an evaluative tool of fenofibrate-induced toxicology in Fischer 344 male rats.","19458390","Fenofibrate","PPAR alpha"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L836,L836)","v":"Fenofibrate"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M836,M836)","v":"PPAR alpha"},0,0,1,0,"PPARA",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K836,K836)","v":"22796657"},2012,"The combined strategy with PPAR? agonism and AT? receptor antagonism is not superior relative to their individual treatment approach in preventing the induction of nephropathy in the diabetic rat.","22796657","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","20580385",2011,"Fenofibrate suppresses microvascular inflammation and apoptosis through adenosine monophosphate-activated protein kinase activation.","20580385","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,1,"PPARA","17935056",2007,"The role of fenofibrate in clinical practice.","17935056","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","17935055",2007,"Preventing type 2 diabetes and cardiovascular disease in metabolic syndrome: the role of PPARalpha.","17935055","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","21392098",2012,"The peroxisome proliferator-activated receptor ? agonist fenofibrate decreases airway reactivity to methacholine and increases endothelial nitric oxide synthase phosphorylation in mouse lung.","21392098","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","20569465",2010,"ROS accumulation and IGF-IR inhibition contribute to fenofibrate/PPARalpha -mediated inhibition of glioma cell motility in vitro.","20569465","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","19322024",2009,"Fenofibrate inhibits adipocyte hypertrophy and insulin resistance by activating adipose PPARalpha in high fat diet-induced obese mice.","19322024","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","21270762",2011,"Fenofibrate, a PPAR? agonist, has renoprotective effects in mice by enhancing renal lipolysis.","21270762","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","20226795",2010,"Fenofibrate antagonizes Chk2 activation by inducing Wip1 expression: implications for cell proliferation and tumorigenesis.","20226795","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","23329136",2013,"Fenofibrate inhibits endothelin-1 expression by peroxisome proliferator-activated receptor ?-dependent and independent mechanisms in human endothelial cells.","23329136","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","15831773",2005,"Individual and combined effects of peroxisome proliferator-activated receptor and {gamma} agonists, fenofibrate and rosiglitazone, on biomarkers of lipid and glucose metabolism in healthy nondiabetic volunteers.","15831773","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","21081159",2011,"Fenofibrate exhibits a high potential to suppress the formation of squamous cell carcinoma in an oral-specific 4-nitroquinoline 1-oxide/arecoline mouse model.","21081159","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","18565798",2008,"Exposure to perfluorooctane sulfonate or fenofibrate causes PPAR-alpha dependent transcriptional responses in chicken embryo hepatocytes.","18565798","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","15838301",2004,"The peroxisome proliferator-activated receptor alpha activator fenofibrate inhibits endothelin-1-induced cardiac fibroblast proliferation.","15838301","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","17904198",2007,"Plasma triglycerides are not related to tissue lipids and insulin sensitivity in elderly following PPAR-alpha agonist treatment.","17904198","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","17876565",2008,"Inhibitory effects of fenofibrate on apoptosis and cell proliferation in human endothelial cells in high glucose.","17876565","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","18562561",2008,"Combination therapy with fenofibrate, a peroxisome proliferator-activated receptor alpha agonist, and simvastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, on experimental traumatic brain injury.","18562561","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","19395558",2009,"Fenofibrate inhibits aldosterone-induced apoptosis in adult rat ventricular myocytes via stress-activated kinase-dependent mechanisms.","19395558","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","23258912",2013,"Direct effects of PPAR? agonists on retinal inflammation and angiogenesis may explain how fenofibrate lowers risk of severe proliferative diabetic retinopathy.","23258912","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,1,"PPARA","21127841",2011,"Evaluation of in vivo genotoxic potential of fenofibrate in rats subjected to two-week repeated oral administration.","21127841","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","15838320",2004,"Activation of peroxisome proliferator-activated receptor-alpha decreases endothelin-1-induced p38 mitogen-activated protein kinase activation in cardiomyocytes.","15838320","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","19102873",2008,"[Fenofibrate improves energy metabolism and attenuates isoproterenol induced acute myocardial ischemic injury in rats via PPAR alpha activation].","19102873","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","18555836",2008,"Adiponectin receptors: expression in Zucker diabetic rats and effects of fenofibrate and metformin.","18555836","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","17727629",2007,"Peroxisome proliferator-activated receptor-alpha agonist fenofibrate regulates IL-12 family cytokine expression in the CNS: relevance to multiple sclerosis.","17727629","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","15843896",2005,"Fenofibrate induces apoptotic injury in cultured human hepatocytes by inhibiting phosphorylation of Akt.","15843896","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","17204199",2006,"[PPARalpha agonist--fenofibrate inhibits LPS-induced tissue factor expression in THP-1 cells].","17204199","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","17924466",2007,"[PPAR alpha activator fenofibrate regressed left ventricular hypertrophy and increased myocardium PPAR alpha expression in spontaneously hypertensive rats].","17924466","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","22937835",2012,"The case for intraocular delivery of PPAR agonists in the treatment of diabetic retinopathy.","22937835","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","18546270",2008,"Activation of PPARalpha inhibits IGF-I-mediated growth and survival responses in medulloblastoma cell lines.","18546270","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,1,"PPARA","17201732",2007,"Effects of fenofibrate and xuezhikang on high-fat diet-induced non-alcoholic fatty liver disease.","17201732","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","18754816",2009,"Effects and mechanisms of PPARalpha activator fenofibrate on myocardial remodelling in hypertension.","18754816","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","22989886",2012,"Gemfibrozil and fenofibrate, Food and Drug Administration-approved lipid-lowering drugs, up-regulate tripeptidyl-peptidase 1 in brain cells via peroxisome proliferator-activated receptor ?: implications for late infantile Batten disease therapy.","22989886","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","21215818",2011,"Fenofibrate, a peroxisome proliferator-activated receptor ? agonist, alters triglyceride metabolism in enterocytes of mice.","21215818","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","23043158",2013,"Therapeutic effects of PPAR? agonists on diabetic retinopathy in type 1 diabetes models.","23043158","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","20740305",2010,"Anti-hyperlipidemic and insulin sensitizing activities of fenofibrate reduces aortic lipid deposition in hyperlipidemic Golden Syrian hamster.","20740305","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,1,"PPARA","16226489",2005,"Paradoxical exacerbation of combined hyperlipidemia in human apolipoprotein A-II transgenic mice treated with fenofibrate.","16226489","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","19644507",2009,"Peroxisome proliferator-activated receptor-alpha activator fenofibrate prevents high-fat diet-induced renal lipotoxicity in spontaneously hypertensive rats.","19644507","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","20511708",2010,"Modulation of LPS-mediated inflammation by fenofibrate via the TRIF-dependent TLR4 signaling pathway in vascular smooth muscle cells.","20511708","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","22768449",2012,"Fenofibrate, a peroxisome proliferator-activated receptor alpha, improves myocardial capillary density in diabetic rats.","22768449","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","19357976",2009,"Analysis of PPARalpha-dependent and PPARalpha-independent transcript regulation following fenofibrate treatment of human endothelial cells.","19357976","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","16546150",2006,"Combined therapy with PPARalpha agonist and L-carnitine rescues lipotoxic cardiomyopathy due to systemic carnitine deficiency.","16546150","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","20204774",2010,"Fenofibrate, a peroxisome proliferator-activated receptor alpha agonist, improves hepatic microcirculatory patency and oxygen availability in a high-fat-diet-induced fatty liver in mice.","20204774","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","16339839",2006,"The PPAR-alpha activator fenofibrate fails to provide myocardial protection in ischemia and reperfusion in pigs.","16339839","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","17611904",2007,"Relationship between insulin resistance and low urinary pH in patients with gout, and effects of PPARalpha agonists on urine pH.","17611904","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","15278363",2004,"Inhibition of melanoma metastases by fenofibrate.","15278363","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","15291748",2004,"Fenofibrate increases the expression of high mobility group AT-hook 2 (HMGA2) gene and induces adipocyte differentiation of orbital fibroblasts from Graves' ophthalmopathy.","15291748","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","19497347",2009,"Peroxisome proliferator-activated receptor alpha (PPARalpha) agonists down-regulate alpha2-macroglobulin expression by a PPARalpha-dependent mechanism.","19497347","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","19033820",2008,"Fenofibrate and pioglitazone do not ameliorate the altered vascular reactivity in aorta of isoproterenol-treated rats.","19033820","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","18436454",2009,"Beneficial effects of fenofibrate on plaque thrombogenicity and plaque stability in atherosclerotic rabbits.","18436454","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","20520642",2010,"Fenofibrate induces effective apoptosis in mantle cell lymphoma by inhibiting the TNFalpha/NF-kappaB signaling axis.","20520642","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","22473497",2012,"Fenofibrate down-regulates renal OCT2-mediated organic cation transport via PPAR?-independent pathways.","22473497","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","23603572",2013,"PPAR? agonist fenofibrate attenuates TNF-?-induced CD40 expression in 3T3-L1 adipocytes via the SIRT1-dependent signaling pathway.","23603572","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","23756370",2013,"Profiling serum bile acid glucuronides in humans: gender divergences, genetic determinants, and response to fenofibrate.","23756370","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","20347778",2010,"The low dose combination of fenofibrate and rosiglitazone halts the progression of diabetes-induced experimental nephropathy.","20347778","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","19054409",2009,"Fenofibrate, a peroxisome proliferator-activated receptor-alpha agonist, exerts anticonvulsive properties.","19054409","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","20346718",2010,"Effect of fenofibrate therapy and ABCA1 polymorphisms on high-density lipoprotein subclasses in the Genetics of Lipid Lowering Drugs and Diet Network.","20346718","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","17610352",2007,"Neurological recovery-promoting, anti-inflammatory, and anti-oxidative effects afforded by fenofibrate, a PPAR alpha agonist, in traumatic brain injury.","17610352","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","20193367",2009,"[Agonist-induced down-regulation of hepatic glucocorticoid receptor via peroxisome proliferator-activated receptor in SD rats].","20193367","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","23872139",2013,"Fenofibrate suppresses melanogenesis in B16-F10 melanoma cells via activation of the p38 mitogen-activated protein kinase pathway.","23872139","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","22514742",2012,"Fenofibrate reduces mortality and precludes neurological deficits in survivors in murine model of Japanese encephalitis viral infection.","22514742","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","18045488",2007,"Peroxisome proliferators-activated alpha agonist treatment ameliorates hepatic damage in rats with obstructive jaundice: an experimental study.","18045488","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","17196944",2007,"Lipid-lowering drugs in the MPTP mouse model of Parkinson's disease: fenofibrate has a neuroprotective effect, whereas bezafibrate and HMG-CoA reductase inhibitors do not.","17196944","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","20226762",2010,"PPARalpha agonist fenofibrate protects the kidney from hypertensive injury in spontaneously hypertensive rats via inhibition of oxidative stress and MAPK activity.","20226762","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","21617875",2011,"Fenofibrate attenuates contact-stimulated cell motility and gap junctional coupling in DU-145 human prostate cancer cell populations.","21617875","Fenofibrate","PPAR alpha"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L900,L900)","v":"Fenofibrate"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M900,M900)","v":"PPAR alpha"},0,0,1,0,"PPARA",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K900,K900)","v":"17597616"},2007,"Activation of peroxisome proliferator-activated receptor-alpha prevents glycogen synthase 3beta phosphorylation and inhibits cardiac hypertrophy.","17597616","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","16569247",2006,"In vitro and in vivo effects of the PPAR-alpha agonists fenofibrate and retinoic acid in endometrial cancer.","16569247","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","22547144",2013,"The PPAR alpha gene is associated with triglyceride, low-density cholesterol and inflammation marker response to fenofibrate intervention: the GOLDN study.","22547144","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","17260462",2006,"[Effect of peroxisome proliferator-activated receptor-alpha agonist on adipokines expression in rats fed with high-fat diet].","17260462","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","18096152",2008,"Suppression of allergen-induced airway inflammation and immune response by the peroxisome proliferator-activated receptor-alpha agonist fenofibrate.","18096152","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","23979788",2013,"Serum preadipocyte factor-1 concentrations in females with obesity and type 2 diabetes mellitus: the influence of very low calorie diet, acute hyperinsulinemia, and fenofibrate treatment.","23979788","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","22437669",2012,"Improved insulin sensitivity after treatment with PPAR? and PPAR? ligands is mediated by genetically modulated transcripts.","22437669","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","17970759",2008,"Effects of combined PPARgamma and PPARalpha agonist therapy on reverse cholesterol transport in the Zucker diabetic fatty rat.","17970759","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","17631136",2007,"Fenofibrate represses interleukin-17 and interferon-gamma expression and improves colitis in interleukin-10-deficient mice.","17631136","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","17577106",2007,"The PPARalpha activator fenofibrate slows down the progression of the left ventricular dysfunction in porcine tachycardia-induced cardiomyopathy.","17577106","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","20510017",2010,"Comparative analysis of fat and muscle proteins in fenofibrate-fed type II diabetic OLETF rats: the fenofibrate-dependent expression of PEBP or C11orf59 protein.","20510017","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","20406163",2010,"Fenofibrate and metabolic syndrome.","20406163","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","21654328",2011,"Reactivation of peroxisome proliferator-activated receptor alpha in spontaneously hypertensive rat: age-associated paradoxical effect on the heart.","21654328","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,1,"PPARA","20507276",2010,"Fenofibrate, homocysteine and renal function.","20507276","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,1,"PPARA","19084088",2008,"After the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study: implications for fenofibrate.","19084088","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","16596808",2005,"Fibrates.","16596808","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","21514001",2011,"Fenofibrate suppresses growth of the human hepatocellular carcinoma cell via PPAR?-independent mechanisms.","21514001","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","17570955",2007,"Ameliorative effect of combination of fenofibrate and rosiglitazone in pressure overload-induced cardiac hypertrophy in rats.","17570955","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","16157299",2005,"Effect of PPAR-alpha and -gamma agonist on the expression of visfatin, adiponectin, and TNF-alpha in visceral fat of OLETF rats.","16157299","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","16985262",2007,"PPAR{alpha} mediates the hypolipidemic action of fibrates by antagonizing FoxO1.","16985262","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","23747828",2013,"High glucose potentiates L-FABP mediated fibrate induction of PPAR? in mouse hepatocytes.","23747828","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","23934460",2013,"PPAR-alpha agonist treatment increases trefoil factor family-3 expression and attenuates apoptosis in the liver tissue of bile duct-ligated rats.","23934460","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","17255874",2007,"Activation of peroxisome proliferator-activated receptor-alpha by fenofibrate prevents myocardial dysfunction during endotoxemia in rats.","17255874","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","19492148",2009,"Inhibition by fibrates of plasminogen activator inhibitor type-1 expression in human adipocytes and preadipocytes.","19492148","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","16477380",2006,"Peroxisome proliferator-activated receptor-alpha selective ligand reduces adiposity, improves insulin sensitivity and inhibits atherosclerosis in LDL receptor-deficient mice.","16477380","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,0,"PPARA","22687626",2012,"Fenofibrate lowers lipid accumulation in myotubes by modulating the PPAR?/AMPK/FoxO1/ATGL pathway.","22687626","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR alpha",0,0,1,1,"PPARA","20460939",2010,"Peroxisome proliferator-activated receptor alpha and alpha/gamma agonists do not cause impairment in renal function in the rat.","20460939","Fenofibrate","PPAR alpha"]
["Fenofibrate","PPAR gamma",0,0,1,0,"PPARG","17184146",2007,"Influence of PPAR-alpha agonist fenofibrate on insulin sensitivity and selected adipose tissue-derived hormones in obese women with type 2 diabetes.","17184146","Fenofibrate","PPAR gamma"]
["Fenofibrate","PPAR gamma",0,0,1,0,"PPARG","15831773",2005,"Individual and combined effects of peroxisome proliferator-activated receptor and {gamma} agonists, fenofibrate and rosiglitazone, on biomarkers of lipid and glucose metabolism in healthy nondiabetic volunteers.","15831773","Fenofibrate","PPAR gamma"]
["Fenofibrate","PPAR gamma",0,0,1,0,"PPARG","22437669",2012,"Improved insulin sensitivity after treatment with PPAR? and PPAR? ligands is mediated by genetically modulated transcripts.","22437669","Fenofibrate","PPAR gamma"]
["Fenofibrate","PPAR gamma",0,0,1,0,"PPARG","15971419",2005,"Inhibition of NF-kappaB signaling by fenofibrate, a peroxisome proliferator-activated receptor-alpha ligand, presents a therapeutic strategy for rheumatoid arthritis.","15971419","Fenofibrate","PPAR gamma"]
["Fenofibrate","PPAR gamma",0,0,1,0,"PPARG","15994444",2005,"PPARalpha, but not PPARgamma, activators decrease macrophage-laden atherosclerotic lesions in a nondiabetic mouse model of mixed dyslipidemia.","15994444","Fenofibrate","PPAR gamma"]
["Fenofibrate","PPAR gamma",0,0,1,0,"PPARG","17570955",2007,"Ameliorative effect of combination of fenofibrate and rosiglitazone in pressure overload-induced cardiac hypertrophy in rats.","17570955","Fenofibrate","PPAR gamma"]
["Fenofibrate","PPAR gamma",0,0,1,0,"PPARG","17145061",2007,"Fenofibrate and pioglitazone improve endothelial function and reduce arterial stiffness in obese glucose tolerant men.","17145061","Fenofibrate","PPAR gamma"]
["Fenofibrate","PPAR gamma",0,0,1,0,"PPARG","22062085",2012,"Combination treatment with pioglitazone and fenofibrate attenuates pioglitazone-mediated acceleration of bone loss in ovariectomized rats.","22062085","Fenofibrate","PPAR gamma"]
["Fenofibrate","PPAR gamma",0,0,1,0,"PPARG","19175377",2009,"Effects of cevoglitazar, a dual PPARalpha/gamma agonist, on ectopic fat deposition in fatty Zucker rats.","19175377","Fenofibrate","PPAR gamma"]
["Fenofibrate","PPAR gamma",0,0,1,0,"PPARG","15669179",2004,"Effect of peroxisome proliferator-activated receptor activators on tumor necrosis factor-alpha expression in neonatal rat cardiac myocytes.","15669179","Fenofibrate","PPAR gamma"]
["Fenofibrate","PPAR gamma",0,0,1,1,"PPARG","22732497",2012,"Fenofibrate-induced nuclear translocation of FoxO3A triggers Bim-mediated apoptosis in glioblastoma cells in vitro.","22732497","Fenofibrate","PPAR gamma"]
["Fenofibrate","PPAR gamma",0,0,1,0,"PPARG","19245804",2009,"Fenofibrate ameliorates diabetic and dyslipidemic profiles in KKAy mice partly via down-regulation of 11beta-HSD1, PEPCK and DGAT2. Comparison of PPARalpha, PPARgamma, and liver x receptor agonists.","19245804","Fenofibrate","PPAR gamma"]
["Fenofibrate","PPAR gamma",0,0,1,0,"PPARG","15917863",2005,"Fenofibrate prevents Rosiglitazone-induced body weight gain in ob/ob mice.","15917863","Fenofibrate","PPAR gamma"]
["Fenofibrate","PPAR gamma",0,0,1,0,"PPARG","16525649",2006,"Effects of PPAR and RXR ligands in semaphorin 6B gene expression of human MCF-7 breast cancer cells.","16525649","Fenofibrate","PPAR gamma"]
["Fenofibrate","PPAR gamma",0,0,1,0,"PPARG","17970759",2008,"Effects of combined PPARgamma and PPARalpha agonist therapy on reverse cholesterol transport in the Zucker diabetic fatty rat.","17970759","Fenofibrate","PPAR gamma"]
["Fenofibrate","PPAR gamma",0,0,1,1,"PPARG","20460939",2010,"Peroxisome proliferator-activated receptor alpha and alpha/gamma agonists do not cause impairment in renal function in the rat.","20460939","Fenofibrate","PPAR gamma"]
["Fenofibrate","PPAR gamma",0,0,1,0,"PPARG","16157299",2005,"Effect of PPAR-alpha and -gamma agonist on the expression of visfatin, adiponectin, and TNF-alpha in visceral fat of OLETF rats.","16157299","Fenofibrate","PPAR gamma"]
["Fenofibrate","PPAR gamma",0,0,1,0,"PPARG","16013444",2005,"Triglyceridemia and peroxisome proliferator-activated receptor-alpha expression are not connected in fenofibrate-treated pregnant rats.","16013444","Fenofibrate","PPAR gamma"]
["Fenofibrate","PPAR gamma",0,0,1,0,"PPARG","23518069",2013,"Fenofibrate ameliorates cardiac hypertrophy by activation of peroxisome proliferator-activated receptor-? partly via preventing p65-NF?B binding to NFATc4.","23518069","Fenofibrate","PPAR gamma"]
["Fenofibrate","PPAR gamma",0,0,1,0,"PPARG","23047938",2012,"Role of fenofibrate in restoring angiogenesis in diabetic and control hind limb ischemic rats.","23047938","Fenofibrate","PPAR gamma"]
["Fenofibrate","PPAR gamma",0,0,1,0,"PPARG","21304067",2011,"Fenofibrate, a PPAR{alpha} agonist, decreases atrogenes and myostatin expression and improves arthritis-induced skeletal muscle atrophy.","21304067","Fenofibrate","PPAR gamma"]
["Fenofibrate","PPAR gamma",0,0,1,0,"PPARG","15291748",2004,"Fenofibrate increases the expression of high mobility group AT-hook 2 (HMGA2) gene and induces adipocyte differentiation of orbital fibroblasts from Graves' ophthalmopathy.","15291748","Fenofibrate","PPAR gamma"]
["Fenofibrate","PPAR gamma",0,0,1,1,"PPARG","17002160",2006,"[PPAR agonists do not come up to expectations. Hope about the preventive effect in type 2 diabetes has come to nought].","17002160","Fenofibrate","PPAR gamma"]
["Fenofibrate","PPAR gamma",0,0,1,0,"PPARG","20347778",2010,"The low dose combination of fenofibrate and rosiglitazone halts the progression of diabetes-induced experimental nephropathy.","20347778","Fenofibrate","PPAR gamma"]
["Fenofibrate","PPAR gamma",0,0,1,0,"PPARG","16339839",2006,"The PPAR-alpha activator fenofibrate fails to provide myocardial protection in ischemia and reperfusion in pigs.","16339839","Fenofibrate","PPAR gamma"]
["Fenofibrate","PPAR gamma",0,0,1,0,"PPARG","19033820",2008,"Fenofibrate and pioglitazone do not ameliorate the altered vascular reactivity in aorta of isoproterenol-treated rats.","19033820","Fenofibrate","PPAR gamma"]
["Fenofibrate","PPAR gamma",0,0,1,0,"PPARG","16009445",2006,"The effect of dual PPAR alpha/gamma stimulation with combination of rosiglitazone and fenofibrate on metabolic parameters in type 2 diabetic patients.","16009445","Fenofibrate","PPAR gamma"]
["Fenofibrate","PPAR gamma",0,0,1,0,"PPARG","17343847",2007,"Antinociceptive and antiedematogenic activities of fenofibrate, an agonist of PPAR alpha, and pioglitazone, an agonist of PPAR gamma.","17343847","Fenofibrate","PPAR gamma"]
["Fenofibrate","PPAR gamma",0,0,1,0,"PPARG","20813100",2010,"Chronic treatment with fibrates elevates superoxide dismutase in adult mouse brain microvessels.","20813100","Fenofibrate","PPAR gamma"]
["Fenofibrate","PPAR gamma",0,0,1,0,"PPARG","16675962",2006,"Peroxisome proliferator-activated receptors increase human sebum production.","16675962","Fenofibrate","PPAR gamma"]
["fenvalerate","pregnane X receptor",0,0,1,0,"NR1I2","20599767",2010,"Dexamethasone transcriptionally increases the expression of the pregnane X receptor and synergistically enhances pyrethroid esfenvalerate in the induction of cytochrome P450 3A23.","20599767","fenvalerate","pregnane X receptor"]
["fipronil","pregnane X receptor",1,0,1,0,"NR1I2","23962444",2013,"The nuclear receptors pregnane X receptor and constitutive androstane receptor contribute to the impact of fipronil on hepatic gene expression linked to thyroid hormone metabolism.","23962444","fipronil","pregnane X receptor"]
["fipronil","constitutive androstane receptor",1,0,1,0,"NR1I3","23962444",2013,"The nuclear receptors pregnane X receptor and constitutive androstane receptor contribute to the impact of fipronil on hepatic gene expression linked to thyroid hormone metabolism.","23962444","fipronil","constitutive androstane receptor"]
["fipronil","Receptors, Glucocorticoid",1,0,1,1,"NR3C1","22542256",2012,"Impacts of the phenylpyrazole insecticide fipronil on larval fish: time-series gene transcription responses in fathead minnow (Pimephales promelas) following short-term exposure.","22542256","fipronil","Receptors, Glucocorticoid"]
["Flutamide","pregnane X receptor",1,1,1,1,"NR1I2","16611858",2006,"Profiling the hepatic effects of flutamide in rats: a microarray comparison with classical aryl hydrocarbon receptor ligands and atypical CYP1A inducers.","16611858","Flutamide","pregnane X receptor"]
["Flutamide","constitutive androstane receptor",1,1,1,1,"NR1I3","16611858",2006,"Profiling the hepatic effects of flutamide in rats: a microarray comparison with classical aryl hydrocarbon receptor ligands and atypical CYP1A inducers.","16611858","Flutamide","constitutive androstane receptor"]
["Flutamide","Receptors, Glucocorticoid",1,1,1,0,"NR3C1","11861975",2002,"Development of two androgen receptor assays using adenoviral transduction of MMTV-luc reporter and/or hAR for endocrine screening.","11861975","Flutamide","Receptors, Glucocorticoid"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L964,L964)","v":"Flutamide"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M964,M964)","v":"Receptors, Glucocorticoid"},1,1,1,0,"NR3C1",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K964,K964)","v":"14967920"},2003,"Alterations of gene expression in adult male rat testis and pituitary shortly after subacute administration of the antiandrogen flutamide.","14967920","Flutamide","Receptors, Glucocorticoid"]
["Genistein","pregnane X receptor",0,0,1,0,"NR1I2","19297428",2009,"Human CYP3A4 and murine Cyp3A11 are regulated by equol and genistein via the pregnane X receptor in a species-specific manner.","19297428","Genistein","pregnane X receptor"]
["Genistein","Receptors, Glucocorticoid",0,0,1,1,"NR3C1","12141392",2002,"Effect of a single treatment (imprinting) with genistein or combined treatment with genistein+benzpyrene on the binding capacity of glucocorticoid and estrogen receptors of adult rats.","12141392","Genistein","Receptors, Glucocorticoid"]
["Genistein","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","24334056",2014,"Lose dose genistein inhibits glucocorticoid receptor and ischemic brain injury in female rats.","24334056","Genistein","Receptors, Glucocorticoid"]
["Genistein","PPAR alpha",0,0,1,0,"PPARA","21946955",2012,"Biochanin A ameliorates the cytokine secretion profile of lipopolysaccharide-stimulated             macrophages by a PPAR?-dependent pathway.","21946955","Genistein","PPAR alpha"]
["Genistein","PPAR alpha",0,0,1,0,"PPARA","15196699",2004,"Genistein enhances expression of genes involved in fatty acid catabolism through activation of PPARalpha.","15196699","Genistein","PPAR alpha"]
["Genistein","PPAR gamma",0,0,1,0,"PPARG","18547799",2009,"Genistein inhibits differentiation of primary human adipocytes.","18547799","Genistein","PPAR gamma"]
["Genistein","PPAR gamma",0,0,1,0,"PPARG","19434061",2009,"Genistein induces adipogenesis but inhibits leptin induction in human synovial fibroblasts.","19434061","Genistein","PPAR gamma"]
["Genistein","PPAR gamma",0,0,1,0,"PPARG","15750262",2004,"Genistein inhibits expressions of NADPH oxidase p22phox and angiotensin II type 1 receptor in aortic endothelial cells from stroke-prone spontaneously hypertensive rats.","15750262","Genistein","PPAR gamma"]
["Genistein","PPAR gamma",0,0,1,0,"PPARG","17052999",2007,"Complementary actions of docosahexaenoic acid and genistein on COX-2, PGE2 and invasiveness in MDA-MB-231 breast cancer cells.","17052999","Genistein","PPAR gamma"]
["Genistein","PPAR gamma",0,0,1,0,"PPARG","22777826",2013,"Functions and action mechanisms of flavonoids genistein and icariin in regulating bone remodeling.","22777826","Genistein","PPAR gamma"]
["Genistein","PPAR gamma",0,0,1,0,"PPARG","19903033",2009,"Repressive effect of the phytoestrogen genistein on estradiol-induced uterine leiomyoma cell proliferation.","19903033","Genistein","PPAR gamma"]
["Genistein","PPAR gamma",0,0,1,0,"PPARG","18029481",2007,"Resveratrol potentiates genistein's antiadipogenic and proapoptotic effects in 3T3-L1 adipocytes.","18029481","Genistein","PPAR gamma"]
["Genistein","PPAR gamma",0,0,1,0,"PPARG","20689342",2010,"The role of peroxisome proliferator-activated receptor-gamma and estrogen receptors in genistein-induced regulation of vascular tone in female rat aortas.","20689342","Genistein","PPAR gamma"]
["Genistein","PPAR gamma",0,0,1,0,"PPARG","18239559",2008,"Enhanced effects of 1,25(OH)(2)D(3) plus genistein on adipogenesis and apoptosis in 3T3-L1 adipocytes.","18239559","Genistein","PPAR gamma"]
["Genistein","PPAR gamma",0,0,1,0,"PPARG","19948157",2010,"Estradiol or genistein prevent Alzheimer's disease-associated inflammation correlating with an increase PPAR gamma expression in cultured astrocytes.","19948157","Genistein","PPAR gamma"]
["Genistein","PPAR gamma",0,0,1,0,"PPARG","18384126",2008,"Inhibition of adipocyte differentiation by phytoestrogen genistein through a potential downregulation of extracellular signal-regulated kinases 1/2 activity.","18384126","Genistein","PPAR gamma"]
["Genistein","PPAR gamma",0,0,1,0,"PPARG","23109410",2012,"Genistein and daidzein, typical soy isoflavones, inhibit TNF-?-mediated downregulation of adiponectin expression via different mechanisms in 3T3-L1 adipocytes.","23109410","Genistein","PPAR gamma"]
["Genistein","PPAR gamma",0,0,1,0,"PPARG","22716961",2013,"Activation of nuclear factor erythroid 2-related factor 2 and PPAR? plays a role in the genistein-mediated attenuation of oxidative stress-induced endothelial cell injury.","22716961","Genistein","PPAR gamma"]
["Genistein","PPAR gamma",0,0,1,0,"PPARG","20397699",2010,"Effect of genistein and daidzein on the proliferation and differentiation of human preadipocyte cell line.","20397699","Genistein","PPAR gamma"]
["Genistein","PPAR gamma",0,0,1,0,"PPARG","21946955",2012,"Biochanin A ameliorates the cytokine secretion profile of lipopolysaccharide-stimulated             macrophages by a PPAR?-dependent pathway.","21946955","Genistein","PPAR gamma"]
["Glutaral","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","2516583",1989,"Chemical crosslinking: a useful tool for evaluations of steroid receptor structures and their functional states in intact cells.","2516583","Glutaral","Receptors, Glucocorticoid"]
["Glutaral","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","2117924",1990,"Transformation of glucocorticoid-receptor complexes is accompanied by dissociation of oligomers in intact cells.","2117924","Glutaral","Receptors, Glucocorticoid"]
["Glycerol","PPAR gamma",0,0,1,0,"PPARG","22700433",2012,"15-Deoxy-?¹²,¹?-prostaglandin J?-glycerol, a putative metabolite of 2-arachidonyl glycerol and a peroxisome proliferator-activated receptor ? ligand, modulates nuclear factor of activated T cells.","22700433","Glycerol","PPAR gamma"]
["Glycerol","PPAR gamma",0,0,1,1,"PPARG","17994460",2007,"Antioxidant U74389G improves glycerol-induced acute renal failure without affecting PPARgamma gene.","17994460","Glycerol","PPAR gamma"]
["Glycerol","PPAR gamma",0,0,1,0,"PPARG","15383226",2004,"Effect of retinoic acid on leptin, glycerol, and glucose levels in mature rat adipocytes in vitro.","15383226","Glycerol","PPAR gamma"]
["glycolic acid","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","16183091",2006,"Aerial oxidation of the glucocorticoid side-chain under pH control.","16183091","glycolic acid","Receptors, Glucocorticoid"]
["hydroquinone","PPAR gamma",0,0,1,0,"PPARG","24564733",2013,"Coffee component hydroxyl hydroquinone (HHQ) as a putative ligand for PPAR gamma and implications in breast cancer.","24564733","hydroquinone","PPAR gamma"]
["Iodine","PPAR alpha",0,0,0,0,"PPARA","19443248",2009,"A complex between 6-iodolactone and the peroxisome proliferator-activated receptor type gamma may mediate the antineoplastic effect of iodine in mammary cancer.","19443248","Iodine","PPAR alpha"]
["Iodine","PPAR gamma",0,0,0,1,"PPARG","23607319",2013,"The extrathyronine actions of iodine as antioxidant, apoptotic, and differentiation factor in various tissues.","23607319","Iodine","PPAR gamma"]
["Iodine","PPAR gamma",0,0,0,0,"PPARG","19443248",2009,"A complex between 6-iodolactone and the peroxisome proliferator-activated receptor type gamma may mediate the antineoplastic effect of iodine in mammary cancer.","19443248","Iodine","PPAR gamma"]
["Iodine","PPAR gamma",0,0,0,0,"PPARG","21690268",2011,"Antineoplastic effect of iodine and iodide in dimethylbenz[a]anthracene-induced mammary tumors: association between lactoperoxidase and estrogen-adduct production.","21690268","Iodine","PPAR gamma"]
["Iodine","PPAR gamma",0,0,0,0,"PPARG","17315977",2007,"Strategies for the labeling of halogen-substituted peroxisome proliferator-activated receptor gamma ligands: potential positron emission tomography and single photon emission computed tomography imaging agents.","17315977","Iodine","PPAR gamma"]
["Iodine","PPAR gamma",0,0,0,0,"PPARG","18630997",2008,"Rosiglitazone effect on radioiodine uptake in thyroid carcinoma patients with high thyroglobulin but negative total body scan: a correlation with the expression of peroxisome proliferator-activated receptor-gamma.","18630997","Iodine","PPAR gamma"]
["Iodine","PPAR gamma",0,0,0,0,"PPARG","17884933",2008,"Oxidative stress in the thyroid gland: from harmlessness to hazard depending on the iodine content.","17884933","Iodine","PPAR gamma"]
["Iodine","PPAR gamma",0,0,0,0,"PPARG","23436219",2013,"RET/PTC and PAX8/PPAR? chromosomal rearrangements in post-Chernobyl thyroid cancer and their association with iodine-131 radiation dose and other characteristics.","23436219","Iodine","PPAR gamma"]
["isoeugenol","PPAR gamma",1,1,1,0,"PPARG","24079732",2013,"Dihydrodehydrodiisoeugenol enhances adipocyte differentiation and decreases lipolysis in murine and human cells.","24079732","isoeugenol","PPAR gamma"]
["Isoproterenol","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","1334806",1992,"Inhibition of anti-CD3 monoclonal antibody-induced T-cell proliferation by dexamethasone, isoproterenol, or prostaglandin E2 either alone or in combination.","1334806","Isoproterenol","Receptors, Glucocorticoid"]
["Isoproterenol","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3735438",1986,"The effect of isoprenaline and physical exertion to exhaustion on the mechanism of glucocorticoid action in the rat heart.","3735438","Isoproterenol","Receptors, Glucocorticoid"]
["Isoproterenol","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","1397987",1992,"Footshock stress-induced supersensitivity to isoprenaline in the isolated pacemaker of the rat: effects of the compounds RU-38486 and RU-28362.","1397987","Isoproterenol","Receptors, Glucocorticoid"]
["Isoproterenol","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8527507",1995,"Effectors of cyclic adenosine 5'-monophosphate up-regulating-oxytocin receptors in rabbit amnion cells: isoproterenol, parathyroid hormone-related protein, and potentiation by cortisol.","8527507","Isoproterenol","Receptors, Glucocorticoid"]
["Isoproterenol","PPAR alpha",0,0,1,1,"PPARA","18982870",2008,"Role of peroxisome proliferator-activated receptor alpha activation in acute myocardial damage induced by isoproterenol in rats.","18982870","Isoproterenol","PPAR alpha"]
["Isoproterenol","PPAR alpha",0,0,1,0,"PPARA","17023522",2007,"Ontogenic loss of brown adipose tissue sensitivity to beta-adrenergic stimulation in the ovine.","17023522","Isoproterenol","PPAR alpha"]
["Isoproterenol","PPAR alpha",0,0,1,0,"PPARA","21508290",2011,"Regulation of the expression of the avian uncoupling protein 3 by isoproterenol and fatty acids in chick myoblasts: possible involvement of AMPK and PPARalpha?","21508290","Isoproterenol","PPAR alpha"]
["Isoproterenol","PPAR alpha",0,0,1,0,"PPARA","19033820",2008,"Fenofibrate and pioglitazone do not ameliorate the altered vascular reactivity in aorta of isoproterenol-treated rats.","19033820","Isoproterenol","PPAR alpha"]
["Isoproterenol","PPAR alpha",0,0,1,0,"PPARA","21854795",2011,"Reduction of isoprenaline-induced myocardial TGF-?1 expression and fibrosis in osthole-treated mice.","21854795","Isoproterenol","PPAR alpha"]
["Isoproterenol","PPAR gamma",0,0,1,0,"PPARG","17023522",2007,"Ontogenic loss of brown adipose tissue sensitivity to beta-adrenergic stimulation in the ovine.","17023522","Isoproterenol","PPAR gamma"]
["Isoproterenol","PPAR gamma",0,0,1,0,"PPARG","19033820",2008,"Fenofibrate and pioglitazone do not ameliorate the altered vascular reactivity in aorta of isoproterenol-treated rats.","19033820","Isoproterenol","PPAR gamma"]
["Isoproterenol","PPAR gamma",0,0,1,0,"PPARG","21558877",2011,"PPAR? dependence of cyclosporine-isoprenaline renovascular interaction: roles of nitric oxide synthase and heme oxygenase.","21558877","Isoproterenol","PPAR gamma"]
["limonene","PPAR alpha",0,0,1,0,"PPARA","23838456",2013,"Preventive and ameliorating effects of citrus D-limonene on dyslipidemia and hyperglycemia in mice with high-fat diet-induced obesity.","23838456","limonene","PPAR alpha"]
["Lovastatin","pregnane X receptor",0,0,1,0,"NR1I2","22634049",2012,"Statins increase cytochrome P450 4F3-mediated eicosanoids production in human liver cells: a PXR dependent mechanism.","22634049","Lovastatin","pregnane X receptor"]
["Lovastatin","pregnane X receptor",0,0,1,0,"NR1I2","12235278",2002,"A cell-based reporter gene assay for determining induction of CYP3A4 in a high-volume system.","12235278","Lovastatin","pregnane X receptor"]
["Lovastatin","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","16101671",2005,"Statin-induced blockade of prenylation alters nucleocytoplasmic shuttling of GTP-binding proteins gamma2 and beta2 and enhances their suppressive effect on glucocorticoid receptor transcriptional activity.","16101671","Lovastatin","Receptors, Glucocorticoid"]
["Lovastatin","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8204848",1994,"[Effect of prolonged intake of lovastatin on the number of glucocorticoid receptors in peripheral blood lymphocytes].","8204848","Lovastatin","Receptors, Glucocorticoid"]
["Lovastatin","PPAR gamma",0,0,1,0,"PPARG","24477821",2014,"Mevalonate deprivation mediates the impact of lovastatin on the differentiation of murine 3T3-F442A preadipocytes.","24477821","Lovastatin","PPAR gamma"]
["Lovastatin","PPAR gamma",0,0,1,0,"PPARG","16425225",2006,"Increased PTEN expression due to transcriptional activation of PPARgamma by Lovastatin and Rosiglitazone.","16425225","Lovastatin","PPAR gamma"]
["Lovastatin","PPAR gamma",0,0,1,0,"PPARG","18097565",2008,"Ciglitazone, an agonist of peroxisome proliferator-activated receptor gamma, exerts potentiated cytostatic/cytotoxic effects against tumor cells when combined with lovastatin.","18097565","Lovastatin","PPAR gamma"]
["Lovastatin","PPAR gamma",0,0,1,0,"PPARG","20543477",2010,"[Mevastatin inhibits the differentiation of thyroid-associated ophthalmopathy derived orbital preadipocytes].","20543477","Lovastatin","PPAR gamma"]
["Lovastatin","PPAR gamma",0,0,1,0,"PPARG","20578043",2010,"Activation of PPAR-? and PTEN cascade participates in lovastatin-mediated accelerated differentiation of oligodendrocyte progenitor cells.","20578043","Lovastatin","PPAR gamma"]
["Mercuric Chloride","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","15549707",2004,"Mercury stimulates rat liver glucocorticoid receptor association with Hsp90 and Hsp70.","15549707","Mercuric Chloride","Receptors, Glucocorticoid"]
["Mercuric Chloride","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","11606802",2001,"Zinc-metallothionein levels are correlated with enhanced glucocorticoid responsiveness in mouse cells exposed to ZnCl(2), HgCl(2), and heat shock.","11606802","Mercuric Chloride","Receptors, Glucocorticoid"]
["Mercuric Chloride","Receptors, Glucocorticoid",1,0,1,1,"NR3C1","17177174",2007,"Interaction of rat renal glucocorticoid receptor with Hsp90 and Hsp70 upon stress provoked by mercury.","17177174","Mercuric Chloride","Receptors, Glucocorticoid"]
["Methotrexate","pregnane X receptor",0,0,1,0,"NR1I2","17163485",2006,"Nuclear receptor interactions in methotrexate induction of human dehydroepiandrosterone sulfotransferase (hSULT2A1).","17163485","Methotrexate","pregnane X receptor"]
["Methotrexate","constitutive androstane receptor",0,0,1,0,"NR1I3","19212336",2009,"Antiepileptic drugs reduce efficacy of methotrexate chemotherapy by downregulation of Reduced folate carrier transport activity.","19212336","Methotrexate","constitutive androstane receptor"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L1028,L1028)","v":"Methotrexate"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M1028,M1028)","v":"constitutive androstane receptor"},0,0,1,0,"NR1I3",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K1028,K1028)","v":"17276571"},2007,"Human constitutive androstane receptor mediated methotrexate induction of human dehydroepiandrosterone sulfotransferase (hSULT2A1).","17276571","Methotrexate","constitutive androstane receptor"]
["Methotrexate","constitutive androstane receptor",0,0,1,0,"NR1I3","21912117",2011,"Antiepileptic drugs reduce the efficacy of methotrexate chemotherapy through accelerated degradation of the reduced folate carrier by the ubiquitin-proteasome pathway.","21912117","Methotrexate","constitutive androstane receptor"]
["Methotrexate","constitutive androstane receptor",0,0,1,0,"NR1I3","17163485",2006,"Nuclear receptor interactions in methotrexate induction of human dehydroepiandrosterone sulfotransferase (hSULT2A1).","17163485","Methotrexate","constitutive androstane receptor"]
["Methotrexate","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","11417479",2001,"High level resistance to glucocorticoids, associated with a dysfunctional glucocorticoid receptor, in childhood acute lymphoblastic leukemia cells selected for methotrexate resistance.","11417479","Methotrexate","Receptors, Glucocorticoid"]
["Methotrexate","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","1547909",1992,"Methotrexate-induced overexpression of functional glucocorticoid receptors in Chinese hamster ovary cells.","1547909","Methotrexate","Receptors, Glucocorticoid"]
["Methotrexate","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","21642336",2011,"Effects of methotrexate on the expression of the translational isoforms of glucocorticoid receptors ? and ?: correlation with methotrexate efficacy in rheumatoid arthritis patients.","21642336","Methotrexate","Receptors, Glucocorticoid"]
["Methotrexate","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","14653715",2003,"Induced protein dimerization in vivo through covalent labeling.","14653715","Methotrexate","Receptors, Glucocorticoid"]
["Methotrexate","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","17118450",2007,"Methotrexate regulates the expression of glucocorticoid receptor alpha and beta isoforms in normal human peripheral mononuclear cells and human lymphocyte cell lines in vitro.","17118450","Methotrexate","Receptors, Glucocorticoid"]
["Methotrexate","Nuclear Receptor Subfamily 4, Group A, Member 2",0,0,1,0,"NR4A2","15972692",2005,"Modulation of orphan nuclear receptor NURR1 expression by methotrexate in human inflammatory joint disease involves adenosine A2A receptor-mediated responses.","15972692","Methotrexate","Nuclear Receptor Subfamily 4, Group A, Member 2"]
["Methotrexate","PPAR alpha",0,0,1,1,"PPARA","24521009",2014,"Protective effect of peroxisome proliferator activator receptor (PPAR)-? and -? ligands against methotrexate-induced nephrotoxicity.","24521009","Methotrexate","PPAR alpha"]
["Methotrexate","PPAR gamma",0,0,1,1,"PPARG","24521009",2014,"Protective effect of peroxisome proliferator activator receptor (PPAR)-? and -? ligands against methotrexate-induced nephrotoxicity.","24521009","Methotrexate","PPAR gamma"]
["Methotrexate","Nuclear Receptor Subfamily 1, Group F, Member 3",0,0,1,0,"RORC","19847432",2010,"The effects of adalimumab and methotrexate treatment on peripheral Th17 cells and IL-17/IL-6 secretion in rheumatoid arthritis patients.","19847432","Methotrexate","Nuclear Receptor Subfamily 1, Group F, Member 3"]
["Methoxychlor","pregnane X receptor",0,0,1,1,"NR1I2","14613717",2003,"Endocrine disruptors induce cytochrome P450 by affecting transcriptional regulation via pregnane X receptor.","14613717","Methoxychlor","pregnane X receptor"]
["Methyl Methanesulfonate","Receptors, Glucocorticoid",1,1,1,0,"NR3C1","8466913",1993,"Differential effects of the reversible thiol-reactive agents arsenite and methyl methanethiosulfonate on steroid binding by the glucocorticoid receptor.","8466913","Methyl Methanesulfonate","Receptors, Glucocorticoid"]
["Methyl Parathion","Nuclear Receptor Subfamily 4, Group A, Member 2",1,0,1,1,"NR4A2","18977431",2009,"Repeated developmental exposure to chlorpyrifos and methyl parathion causes persistent alterations in nicotinic acetylcholine subunit mRNA expression with chlorpyrifos altering dopamine metabolite levels.","18977431","Methyl Parathion","Nuclear Receptor Subfamily 4, Group A, Member 2"]
["Mifepristone","pregnane X receptor",0,0,1,0,"NR1I2","11455014",2001,"The antiglucocorticoid RU486 inhibits phenobarbital induction of the chicken CYP2H1 gene in primary hepatocytes.","11455014","Mifepristone","pregnane X receptor"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,1,"NR3C1","23337135",2013,"A new therapeutic approach in the medical treatment of Cushing's syndrome: glucocorticoid receptor blockade with mifepristone.","23337135","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2843562",1988,"Adrenocorticotropin and cortisol-induced changes in urinary sodium and potassium excretion in man: effects of spironolactone and RU486.","2843562","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","17242213",2007,"Human glucocorticoid receptor beta binds RU-486 and is transcriptionally active.","17242213","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3142916",1988,"Glucocorticoids stimulate prostaglandin synthesis in human amnion cells by a receptor-mediated mechanism.","3142916","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2838686",1988,"Receptor-mediated effects of glucocorticoids on inflammation: enhancement of the inflammatory response with a glucocorticoid antagonist.","2838686","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3199809",1988,"RU 486 stabilizes the glucocorticoid receptor in a non-transformed high molecular weight form in intact thymus cells under physiological conditions.","3199809","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","16867184",2006,"Brief treatment with the glucocorticoid receptor antagonist mifepristone normalises the corticosterone-induced reduction of adult hippocampal neurogenesis.","16867184","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3996417",1985,"Chick oviduct glucocorticosteroid receptor. Specific binding of the synthetic steroid RU 486 and immunological studies with antibodies to chick oviduct progesterone receptor.","3996417","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","23303058",2013,"Blocking mineralocorticoid receptors impairs, blocking glucocorticoid receptors enhances memory retrieval in humans.","23303058","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,1,"NR3C1","12011303",2002,"Mifepristone (RU 486) for Alzheimer's disease.","12011303","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2781282",1989,"Contragestion and other clinical applications of RU 486, an antiprogesterone at the receptor.","2781282","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","10852622",2000,"Apoptosis of thymocytes during acute graft-versus-host disease is independent of glucocorticoids.","10852622","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3224726",1988,"[Binding characteristics of RU 486 with glucocorticoid and progestin receptors].","3224726","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2343294",1990,"RU 486.","2343294","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3228019",1988,"Glucocorticoid antagonists and the role of glucocorticoids at the resting and stress state.","3228019","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2743328",1989,"Comparison of in vivo activation of triamcinolone acetonide- and RU 38486-receptor complexes in the CEM-C7 and IM-9 human leukemic cell lines.","2743328","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","10642853",1999,"A role of glucocorticoid receptors in the guinea pig vestibular system.","10642853","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2683974",1989,"[Antagonist and agonist effects of the antiprogesterone RU 486].","2683974","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2318865",1990,"Suppression of rat mammary tumor cell growth in vitro by glucocorticoids requires serum proteins. Characterization of wild type and glucocorticoid-resistant epithelial tumor cells.","2318865","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3972969",1985,"RU486, a progestin and glucocorticoid antagonist, inhibits the growth of breast cancer cells via the progesterone receptor.","3972969","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,1,"NR3C1","23436494",2013,"Mifepristone for management of Cushing's syndrome.","23436494","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3242623",1988,"Association of the glucocorticoid receptor binding subunit with the 90K nonsteroid-binding component is stabilized by both steroidal and nonsteroidal antiglucocorticoids in intact cells.","3242623","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","17070047",2007,"Parallel strategies for the preparation and selection of liver-targeted glucocorticoid receptor antagonists.","17070047","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","16644794",2006,"Mifepristone (RU38486) influences the core temperature response of term pregnant rats to intraperitoneal lipopolysaccharide.","16644794","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","1778181",1991,"The steroid hormone antagonist RU486. Mechanism at the cellular level and clinical applications.","1778181","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2626040",1989,"Binding studies of the antiglucocorticoid RU38486 in Daudi and Raji lymphoma cells.","2626040","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2303427",1990,"Mechanism of action of a steroidal antiglucocorticoid in lymphoid cells.","2303427","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","16901932",2006,"Differential interaction of RU486 with the progesterone and glucocorticoid receptors.","16901932","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","17274977",2007,"Diffusion analysis of glucocorticoid receptor and antagonist effect in living cell nucleus.","17274977","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3009988",1986,"Antagonism of glucocorticoid induction of Epstein-Barr virus early antigens by different steroids in Daudi lymphoma cells.","3009988","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","22713910",2012,"Post-exposure sleep deprivation facilitates correctly timed interactions between glucocorticoid and adrenergic systems, which attenuate traumatic stress responses.","22713910","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2988258",1985,"Studies on the glucocorticoid-receptor blocking action of RU 38486 in cultured ACTH-secreting human pituitary tumour cells and normal rat pituitary cells.","2988258","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","10651433",2000,"Labeling of the glucocorticoid receptor and Na,K-ATPase in a rat otitis media model.","10651433","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2982481",1985,"Comparison of the actions of RU 38486 and megestrol acetate in the model of a transplantable adrenocorticotropin- and prolactin-secreting rat pituitary tumor.","2982481","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","10748103",2000,"Selective activation of the glucocorticoid receptor by steroid antagonists in human breast cancer and osteosarcoma cells.","10748103","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2936615",1985,"Effects of steroid hormones and antihormones in cultured cells.","2936615","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","22819113",2012,"Mifepristone inhibits GR? coupled prostate cancer cell proliferation.","22819113","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3035286",1987,"Glucocorticoid receptors bound to the antagonist RU486 are not downregulated despite their capacity to interact in vitro with defined gene regions.","3035286","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","23201377",2013,"Re: mifepristone inhibits GR? coupled prostate cancer cell proliferation.","23201377","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","4084295",1985,"Activation of rat liver glucocorticoid receptor bound to the antiglucocorticoid RU38486.","4084295","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","4039656",1985,"The antiprogestin RU38 486: receptor-mediated progestin versus antiprogestin actions screened in estrogen-insensitive T47Dco human breast cancer cells.","4039656","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2877119",1986,"Analysis of the relation between receptor binding affinity and antagonist efficacy of antiglucocorticoids.","2877119","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","16889838",2006,"Antiviral effects of mifepristone on human immunodeficiency virus type-1 (HIV-1): targeting Vpr and its cellular partner, the glucocorticoid receptor (GR).","16889838","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","23159706",2013,"Inhibition of glucocorticoid receptors ameliorates hypobaric hypoxia induced memory impairment in rat.","23159706","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2875214",1986,"Antiglucocorticoid steroids have increased agonist activity in those hepatoma cell lines that are more sensitive to glucocorticoids.","2875214","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","4055982",1985,"RU 486 inhibits peripheral effects of glucocorticoids in humans.","4055982","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2864478",1985,"RU 38486: a potent antiglucocorticoid in vitro and in vivo.","2864478","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2554782",1989,"[Antiglucocorticoid action of RU 486].","2554782","Mifepristone","Receptors, Glucocorticoid"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L1092,L1092)","v":"Mifepristone"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M1092,M1092)","v":"Receptors, Glucocorticoid"},0,0,1,0,"NR3C1",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K1092,K1092)","v":"4046603"},1985,"Autoradiographic study of the nuclear transfer of the antiglucocorticoid compound RU38486 in mouse tissues.","4046603","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3292573",1988,"RU486 (an anti-steroid hormone) receptor structure and heat shock protein mol. wt 90,000 (hsp 90).","3292573","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","23211818",2013,"Mifepristone, a blocker of glucocorticoid receptors, promotes photoreceptor death.","23211818","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","23280517",2013,"Effects of glucocorticoid receptor antagonist, RU486, on the proliferative and differentiation capabilities of bone marrow mesenchymal stromal cells in ovariectomized rats.","23280517","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","17873323",2007,"Role of glucocorticoids and glucocorticoid receptor in priming of macrophages caused by glucocorticoid receptor blockade.","17873323","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2912696",1989,"Membrane receptor-mediated electrophysiological effects of glucocorticoid on mammalian neurons.","2912696","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2414136",1985,"Preliminary results with the antiprogestational compound RU-486 (mifepristone) for interruption of early pregnancy.","2414136","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","11801359",2002,"Mifepristone protects CA1 hippocampal neurons following traumatic brain injury in rat.","11801359","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","16782211",2006,"The efficacy of mifepristone in the reduction and prevention of olanzapine-induced weight gain in rats.","16782211","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3757904",1986,"Antagonism of female sexual behavior with intracerebral implants of antiprogestin RU 38486: correlation with binding to neural progestin receptors.","3757904","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3669658",1987,"Antiprogesterone and antiglucocorticoid actions of RU 486 on rabbit mammary gland explant cultures. Evidence for a persistent inhibitory action of residual progesterone upon the mammary tissue.","3669658","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","17109015",2006,"Is mifepristone useful in psychotic depression?","17109015","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2424746",1986,"Blockade of glucocorticoid receptor binding and inhibition of dexamethasone-induced muscle atrophy in the rat by RU38486, a potent glucocorticoid antagonist.","2424746","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","1761197",1991,"The interaction of peripherally and centrally administered dexamethasone and RU 38486 on morphine analgesia in mice.","1761197","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","23797878",2013,"Mifepristone treatment affects the response to repeated amphetamine injections, but does not attenuate the expression of sensitization.","23797878","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3594432",1987,"Prolactin release-inhibitory effects of progesterone, megestrol acetate, and mifepristone (RU 38486) by cultured rat pituitary tumor cells.","3594432","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3593772",1987,"Immunologically distinct binding molecules for progesterone and RU38486 in the chick oviduct cytosol.","3593772","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","17606285",2007,"Comparison of two structurally diverse glucocorticoid receptor agonists: cortivazol selectively regulates a distinct set of genes separate from dexamethasone in CEM cells.","17606285","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,1,"NR3C1","24205903",2014,"Mifepristone: a potential clinical agent based on its anti-progesterone and anti-glucocorticoid properties.","24205903","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3947332",1986,"Physiological action and receptor binding of a newly synthesized and novel antiglucocorticoid.","3947332","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","16770728",2006,"The effect of mifepristone (RU 486) on plasma cortisol in Alzheimer's disease.","16770728","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3773512",1986,"A possible role for endogenous glucocorticoids in orchiectomy-induced atrophy of the rat levator ani muscle: studies with RU 38486, a potent and selective antiglucocorticoid.","3773512","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","11698067",2001,"Intracerebroventricular administration of a glucocorticoid receptor antagonist enhances the cardiovascular responses to brief restraint stress.","11698067","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","11312148",2001,"The steroid receptor antagonists RU40555 and RU486 activate glucocorticoid receptor translocation and are not excreted by the steroid hormones transporter in L929 cells.","11312148","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3560943",1987,"Plasma concentrations and receptor binding of RU 486 and its metabolites in humans.","3560943","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","11682470",2002,"Allosteric effects of dexamethasone and RU486 on glucocorticoid receptor-DNA interactions.","11682470","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","24102404",2014,"Global clinical response in Cushing's syndrome patients treated with mifepristone.","24102404","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","11387213",2001,"Hormone-induced nucleosome positioning in the MMTV promoter is reversible.","11387213","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","11395507",2001,"p65-activated histone acetyltransferase activity is repressed by glucocorticoids: mifepristone fails to recruit HDAC2 to the p65-HAT complex.","11395507","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3416819",1988,"Differences in the interaction of RU 486 and ketoconazole with the second binding site of the glucocorticoid receptor.","3416819","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3386225",1988,"Evidence for sex-dependent anabolic response to androgenic steroids mediated by muscle glucocorticoid receptors in the rat.","3386225","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","17509631",2007,"The glucocorticoid agonist activities of mifepristone (RU486) and progesterone are dependent on glucocorticoid receptor levels but not on EC50 values.","17509631","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","24016618",2013,"Glucocorticoid receptor antagonism as a novel therapy for triple-negative breast cancer.","24016618","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3386227",1988,"Effects of progesterone, promegestone and RU 486 on glucocorticoid receptor levels in primary cultures of mouse mammary epithelial cells.","3386227","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","11238624",2001,"Endogenous glucocorticoids play a positive regulatory role in the anti-keyhole limpet hemocyanin in vivo antibody response.","11238624","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3795940",1986,"Physical characterization of the activated and non-activated forms of the glucocorticoid-receptor complex bound to the steroid antagonist [3H]RU 486.","3795940","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3297781",1987,"Glucocorticoid antagonists.","3297781","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3386269",1988,"A correlative study of RU38486 biopotency and competition with [3H]dexamethasone for receptors in the rat central nervous system.","3386269","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","10516483",1999,"Corticotropin-releasing effect of hexarelin, a peptidyl GH secretagogue, in normal subjects pretreated with metyrapone or RU-486, a glucocorticoid receptor antagonist, and in patients with Addison's disease.","10516483","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","11451379",2001,"Heat shock preconditioning and pretreatment with glucocorticoid antagonist RU 486 protect rat myogenic cells H9c2 against glutamate-induced cell death.","11451379","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","23527822",2013,"Mifepristone pretreatment reduces ethanol withdrawal severity in vivo.","23527822","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2550833",1989,"On the role of brain mineralocorticoid (type I) and glucocorticoid (type II) receptors in neuroendocrine regulation.","2550833","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","23544271",2013,"Glucocorticoid-induced hypertension and cardiac injury: effects of mineralocorticoid and glucocorticoid receptor antagonism.","23544271","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2539256",1989,"Familial and iatrogenic cortisol receptor resistance.","2539256","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3342067",1988,"RU 486 stabilizes a high molecular weight form of the glucocorticoid receptor containing the 90K non-steroid binding protein in intact thymus cells.","3342067","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3344063",1988,"Antiglucocorticoid RU 38486 attenuates retention of a behaviour and disinhibits the hypothalamic-pituitary adrenal axis at different brain sites.","3344063","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3347052",1988,"RU486 inhibits induction of aromatase by dexamethasone via glucocorticoid receptor in cultured human skin fibroblasts.","3347052","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","12695529",2003,"Glucocorticoid receptor antagonism by cyproterone acetate and RU486.","12695529","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3382699",1988,"In vitro activation of rat cardiac glucocorticoid antagonist- versus agonist-receptor complexes.","3382699","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,1,"NR3C1","17956963",2007,"Pathopharmacology of excessive hemorrhage in mifepristone abortions.","17956963","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","11179906",2000,"Nonsteroidal progesterone receptor ligands with unprecedented receptor selectivity.","11179906","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","23598532",2013,"Medical management of Cushing's syndrome.","23598532","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3790617",1987,"Microheterogeneity of agonist and antagonist glucocorticoid receptor complexes detected by isoelectric focusing and modifications induced by receptor activation.","3790617","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3347064",1988,"A model of antiglucocorticoid action for designing a potent glucocorticoid antagonist.","3347064","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3377791",1988,"Interaction of antiglucocorticoid RU 486 with rat kidney glucocorticoid receptor.","3377791","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","11012846",2000,"Selective blockade of the mineralocorticoid receptor impairs hypothalamic-pituitary-adrenal axis expression of habituation.","11012846","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","11065175",2000,"Effect of neonatal treatment with mifepristone or tamoxifen on the binding capacity of the thymic glucocorticoid or uterine estrogen receptor of adult rats: data on the mechanism of hormonal imprinting.","11065175","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,1,"NR3C1","24368142",2014,"Impaired imprinting and social behaviors in chicks exposed to mifepristone, a glucocorticoid receptor antagonist, during the final week of embryogenesis.","24368142","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3773520",1986,"Physicochemical characteristics of the interaction of the glucocorticoid antagonist RU38486 with glucocorticoid receptors in vitro, and the role of molybdate.","3773520","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","16807278",2006,"Mifepristone-induced amenorrhoea is associated with an increase in microvessel density and glucocorticoid receptor and a decrease in stromal vascular endothelial growth factor.","16807278","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2362447",1990,"Evidence from pulse-chase labeling studies that the antiglucocorticoid hormone RU486 stabilizes the nonactivated form of the glucocorticoid receptor in mouse lymphoma cells.","2362447","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","23624748",2013,"RU486, a glucocorticoid receptor antagonist, induces apoptosis in U937 human lymphoma cells through reduction in mitochondrial membrane potential and activation of p38 MAPK.","23624748","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","24319742",2013,"Effect of mifepristone on glucocorticoid receptor gene expression in the liver of rats with streptozotocin-induced diabetes.","24319742","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","12011091",2002,"RU486-induced glucocorticoid receptor agonism is controlled by the receptor N terminus and by corepressor binding.","12011091","Mifepristone","Receptors, Glucocorticoid"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L1156,L1156)","v":"Mifepristone"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M1156,M1156)","v":"Receptors, Glucocorticoid"},0,0,1,0,"NR3C1",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K1156,K1156)","v":"11911951"},2002,"CDB-4124 and its putative monodemethylated metabolite, CDB-4453, are potent antiprogestins with reduced antiglucocorticoid activity: in vitro comparison to mifepristone and CDB-2914.","11911951","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","22140582",2011,"Mifepristone prevents stress-induced apoptosis in newborn neurons and increases AMPA receptor expression in the dentate gyrus of C57/BL6 mice.","22140582","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","21856283",2011,"REDD1 (regulated in development and DNA damage response 1) expression in skeletal muscle as a surrogate biomarker of the efficiency of glucocorticoid receptor blockade.","21856283","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","21878843",2011,"Oral mifepristone for chronic central serous chorioretinopathy.","21878843","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","1324011",1992,"Antiglucocorticoid treatment disrupts endocrine cycle and nocturnal sleep pattern.","1324011","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","21887496",2011,"Environmental-induced differences in corticosterone and glucocorticoid receptor blockade of amphetamine self-administration in rats.","21887496","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","15219650",2004,"The glucocorticoid receptor antagonist mifepristone reduces ethanol intake in rats under limited access conditions.","15219650","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","22008998",2012,"Glucocorticoid receptor antagonist sensitizes TRAIL-induced apoptosis in renal carcinoma cells through up-regulation of DR5 and down-regulation of c-FLIP(L) and Bcl-2.","22008998","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","12897084",2003,"Glucocorticoid antagonist RU38486 fails to block acid-induced muscle wasting in vivo or in vitro.","12897084","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","15276881",2004,"RU486 blocks fasting-induced decrease of neuronal nitric oxide synthase in the rat paraventricular nucleus.","15276881","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","21211465",2011,"Betamethasone, progesterone and RU-486 (mifepristone) exert similar effects on connexin expression in trophoblast-derived HTR-8/SVneo cells.","21211465","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","22093480",2012,"In vitro effects of RU486 on proliferation and differentiation capabilities of human bone marrow mesenchymal stromal cells.","22093480","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","19799583",2010,"Mifepristone and spironolactone differently alter cocaine intravenous self-administration and cocaine-induced locomotion in C57BL/6J mice.","19799583","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","20339369",2010,"Mifepristone reduces weight gain and improves metabolic abnormalities associated with risperidone treatment in normal men.","20339369","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","1336944",1992,"Sparfloxacin, ethambutol, and cortisol receptor inhibitor RU-40 555 treatment for disseminated Mycobacterium avium complex infection of normal C57BL/6 mice.","1336944","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,1,"NR3C1","20297693",2010,"[The impact of early developmental impairment of the receptor-dependent glucocorticoid action on the pituitary adrenal axis activity and behavior of male rats].","20297693","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","22186023",2012,"Pharmacological interference with the glucocorticoid system influences symptoms and lifespan in a mouse model of Rett syndrome.","22186023","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","20149549",2010,"Mifepristone decreases depression-like behavior and modulates neuroendocrine and central hypothalamic-pituitary-adrenocortical axis responsiveness to stress.","20149549","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","15449237",2004,"Role of the low-affinity glucocorticoid receptor in the regulation of behavior and energy metabolism in the migratory red knot Calidris canutus islandica.","15449237","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","1614417",1992,"Molecular mechanism of RU 486 action: a review.","1614417","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","20093322",2011,"Differential effect of glucocorticoid receptor antagonists on glucocorticoid receptor nuclear translocation and DNA binding.","20093322","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","1996987",1991,"Hepatic glucocorticoid receptor behaves differently when its hormone binding site is occupied by agonist (triamcinolone acetonide) or antagonist (RU486) steroid ligands.","1996987","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","15479233",2004,"Differential effects of RU486 reveal distinct mechanisms for glucocorticoid repression of prostaglandin E release.","15479233","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","19923812",2009,"Blocking the glucocorticoid receptor with RU-486 does not prevent glucocorticoid control of autoimmune mouse hearing loss.","19923812","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,1,"NR3C1","16046483",2005,"Pathophysiology of mifepristone-induced septic shock due to Clostridium sordellii.","16046483","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","15548857",2004,"Effect of glucocorticoïd receptor ligands on myosin heavy chains expression in rat skeletal muscles during controllable stress.","15548857","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","21276847",2011,"Chronic blockade of glucocorticoid receptors by RU486 enhances lipopolysaccharide-induced depressive-like behaviour and cytokine production in rats.","21276847","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","1621865",1992,"Mifepristone (RU 486), a blocker of type II glucocorticoid and progestin receptors, reverses a dietary form of obesity.","1621865","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","21245955",2011,"Inhibition of glucocorticoid-induced alteration of vimentin by a glucocorticoid receptor antagonist RU486 in the organ-cultured rat lens.","21245955","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","20964639",2010,"Mifepristone (RU486) restores humoral and T cell-mediated immune response in endotoxin immunosuppressed mice.","20964639","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","20829633",2010,"Medical treatment of Cushing's syndrome: glucocorticoid receptor antagonists and mifepristone.","20829633","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","15120421",2004,"In vitro antiprogestational/antiglucocorticoid activity and progestin and glucocorticoid receptor binding of the putative metabolites and synthetic derivatives of CDB-2914, CDB-4124, and mifepristone.","15120421","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","14698071",2003,"The pharmacokinetics of mifepristone in humans reveal insights into differential mechanisms of antiprogestin action.","14698071","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","15127079",2004,"Improvements in neurocognitive function and mood following adjunctive treatment with mifepristone (RU-486) in bipolar disorder.","15127079","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","21438774",2011,"Systemic and intrahippocampal administrations of the glucocorticoid receptor antagonist RU38486 impairs fear memory reconsolidation in rats.","21438774","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","14671179",2003,"The effect of mifepristone on the expression of steroid hormone receptors in human decidua and placenta: a randomized placebo-controlled double-blind study.","14671179","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","18474108",2008,"RU486 did not exacerbate cytokine release in mice challenged with LPS nor in db/db mice.","18474108","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","20637751",2010,"Inhibition of glucocorticoid-induced changes of Na(+), K(+)-ATPase in rat lens by a glucocorticoid receptor antagonist RU486.","20637751","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","21451860",2011,"Glucocorticoid receptors take part in the apoptotic process of human lens epithelial cells, but the glucocorticoid receptor antagonist RU486 does not rescue the cells fully.","21451860","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","18341515",2008,"Metyrapone and mifepristone reverse recognition memory loss induced by spontaneous morphine withdrawal in mice.","18341515","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2152931",1990,"Transient inhibition of RU 486 antiglucocorticoid action by dexamethasone.","2152931","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","18347111",2008,"Chlamydia pneumoniae growth inhibition in cells by the steroid receptor antagonist RU486 (mifepristone).","18347111","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","21617839",2011,"Phase II study of the antiretroviral activity and safety of the glucocorticoid receptor antagonist mifepristone in HIV-1-infected patients.","21617839","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2051768",1991,"The effect of interleukin-1 alpha and the glucocorticoid receptor blocker RU 38486 on total and myofibrillar protein breakdown in skeletal muscle.","2051768","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","18708183",2009,"Preclinical assessment for selectively disrupting a traumatic memory via postretrieval inhibition of glucocorticoid receptors.","18708183","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","20485384",2010,"Mifepristone increases gamma-retroviral infection efficiency by enhancing the integration of virus into the genome of infected cells.","20485384","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","16165340",2005,"Mifepristone (RU486) inhibits lateral perforant path long-term potentiation in hippocampal slices from prenatally morphine-exposed female rats.","16165340","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","1422922",1992,"[Respective role of mifepristone (RU486) binding to blood and tissue proteins in its quantitative distribution in the body].","1422922","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","1421316",1992,"[Radiation protective properties of a synthetic antagonist of glucocorticoids RU 38486].","1421316","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","1397987",1992,"Footshock stress-induced supersensitivity to isoprenaline in the isolated pacemaker of the rat: effects of the compounds RU-38486 and RU-28362.","1397987","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","1348626",1992,"Duration of antagonizing effect of RU486 on the agonist induction of tyrosine aminotransferase via glucocorticoid receptor.","1348626","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","16160710",2006,"Clinical and biological effects of mifepristone treatment for psychotic depression.","16160710","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","18255098",2008,"Persistent effects of mifepristone (RU-486) on cortisol levels in bipolar disorder and schizophrenia.","18255098","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","21515309",2011,"Antidepressant-like effects of mineralocorticoid but not glucocorticoid antagonists in the lateral septum: interactions with the serotonergic system.","21515309","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","22500955",2014,"Binge-like ethanol consumption increases corticosterone levels and neurodegneration whereas occupancy of type II glucocorticoid receptors with mifepristone is neuroprotective.","22500955","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,1,"NR3C1","22466348",2012,"Mifepristone, a glucocorticoid receptor antagonist, produces clinical and metabolic benefits in patients with Cushing's syndrome.","22466348","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","18052970",2007,"Brief treatment with the glucocorticoid receptor antagonist mifepristone normalizes the reduction in neurogenesis after chronic stress.","18052970","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","19116788",2009,"Selective transcriptional regulation of aromatase gene by vitamin D, dexamethasone, and mifepristone in human glioma cells.","19116788","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","19372222",2009,"The X-ray structure of RU486 bound to the progesterone receptor in a destabilized agonistic conformation.","19372222","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","15676061",2005,"Polyethylene glycol but not mifepristone prevents intestinal lymphocyte loss following treadmill exercise in mice.","15676061","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,1,"NR3C1","22543346",2012,"The use of the glucocorticoid receptor antagonist mifepristone in Cushing's syndrome.","22543346","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","1580850",1992,"Mifepristone blocks specific glucocorticoid receptor binding in rabbit iris-ciliary body.","1580850","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","12686538",2003,"The three-dimensional structures of antagonistic and agonistic forms of the glucocorticoid receptor ligand-binding domain: RU-486 induces a transconformation that leads to active antagonism.","12686538","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","15974908",2005,"C-1073 (mifepristone) in the adjunctive treatment of Alzheimer's disease.","15974908","Mifepristone","Receptors, Glucocorticoid"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L1220,L1220)","v":"Mifepristone"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M1220,M1220)","v":"Receptors, Glucocorticoid"},0,0,1,0,"NR3C1",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K1220,K1220)","v":"15652874"},2005,"Effects of adjunctive mifepristone (RU-486) administration on neurocognitive function and symptoms in schizophrenia.","15652874","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2261452",1990,"Transformation of glucocorticoid receptors bound to the antagonist RU 486: effects of alkaline phosphatase.","2261452","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","15961248",2005,"Glucocorticoid receptor involvement in pair bonding in female prairie voles: the effects of acute blockade and interactions with central dopamine reward systems.","15961248","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","15889946",2005,"An 8-week open-label trial of a 6-day course of mifepristone for the treatment of psychotic depression.","15889946","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","19493627",2009,"Association of glucocorticoid with stress-induced modulation of body temperature, blood glucose and innate immunity.","19493627","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","15571913",2004,"Effects of glucocorticoid receptor antagonist on CAPs threshold shift due to short-term sound exposure in guinea pigs.","15571913","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","19141586",2009,"Combined receptor antagonist stimulation of the hypothalamic-pituitary-adrenal axis test identifies impaired negative feedback sensitivity to cortisol in obese men.","19141586","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2253240",1990,"Glucocorticoid receptor monoclonal antibodies define the biological action of RU 38486 in intact B16 melanoma cells.","2253240","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","22533823",2012,"Drugs in the medical treatment of Cushing's syndrome--an update on mifepristone and pasireotide.","22533823","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","19561138",2009,"Dexamethasone and mifepristone increase retroviral infectivity through different mechanisms.","19561138","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","15631890",2005,"Blockage of glucocorticoid, but not mineralocorticoid receptors prevents the persistent increase in circulating basal corticosterone concentrations following stress in the rat.","15631890","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","22674211",2012,"Medical management of Cushing's disease: what is the future?","22674211","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","12824023",2003,"An evaluation of a C-glucuronide as a liver targeting group: conjugate of a glucocorticoid antagonist.","12824023","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","16530421",2006,"The use of mifepristone in the treatment of neuropsychiatric disorders.","16530421","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","1812008",1991,"Activation of glucocorticoid receptors and the effect of naloxone during hemorrhagic hypotension.","1812008","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","19318138",2009,"A multisite trial of mifepristone for the treatment of psychotic depression: a site-by-treatment interaction.","19318138","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","1564428",1992,"The glucocorticoid antagonist mifepristone reveals abnormal regulation of the adrenocortical system in obese Zucker rats.","1564428","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","19120154",2008,"Differential effects of the new glucocorticoid receptor antagonist ORG 34517 and RU486 (mifepristone) on glucocorticoid receptor nuclear translocation in the AtT20 cell line.","19120154","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","15922554",2005,"RU486 blocks the anti-inflammatory effects of exercise in a murine model of allergen-induced pulmonary inflammation.","15922554","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","19635558",2009,"Identification of the functional domain of glucocorticoid receptor involved in RU486 antagonism.","19635558","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","1562546",1992,"Mutations in the \"zinc fingers\" or in the N-terminal region of the DNA binding domain of the human glucocorticosteroid receptor facilitate its salt-induced transformation, but do not modify hormone binding.","1562546","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,1,"NR3C1","9046951",1997,"RU486 (mifepristone): mechanisms of action and clinical uses.","9046951","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","9769155",1998,"Sympathectomy-induced immune changes are not abrogated by the glucocorticoid receptor blocker RU-486.","9769155","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","6327286",1984,"DNA binding properties of glucocorticosteroid receptors bound to the steroid antagonist RU-486.","6327286","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8483945",1993,"Dexamethasone negatively regulates the activity of a chimeric dihydrofolate reductase/glucocorticoid receptor protein.","8483945","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,1,"NR3C1","9048964",1997,"Antiprogestins and iatrogenic glucocorticoid resistance.","9048964","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8792846",1996,"Blocking effect of anti-mouse interleukin-6 monoclonal antibody and glucocorticoid receptor antagonist, RU38486, on metallothionein-inducing activity of serum from lipopolysaccharide-treated mice.","8792846","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8248349",1993,"The effects of the acute administration of RU 486 on dietary fat preference in fasted lean and obese men.","8248349","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8532822",1995,"Anxiolytic-like effects of selective mineralocorticoid and glucocorticoid antagonists on fear-enhanced behavior in the elevated plus-maze.","8532822","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8534614",1995,"Effect of RU 486 on the atrophogenic and antiinflammatory effects of glucocorticoids in skin.","8534614","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","7825898",1994,"Glucocorticoid receptor (GR)-mediated effects on cocaine kindling in rats.","7825898","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8564931",1996,"Muscle hypercatabolism during cancer cachexia is not reversed by the glucocorticoid receptor antagonist RU38486.","8564931","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","9537819",1997,"Increased hypothalamic neuropeptide Y concentration or hyperphagia in streptozotocin-diabetic rats are not mediated by glucocorticoids.","9537819","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","9700756",1998,"Effects of adrenalectomy and glucocorticoid receptor antagonist, RU38486, on pituitary growth hormone-releasing hormone receptor gene expression in rats.","9700756","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","7627771",1995,"Blockade of the glucocorticoid receptor with RU 486: effects in vitro and in vivo on human adipose tissue lipoprotein lipase activity.","7627771","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","7700503",1994,"Antagonism of type II, but not type I glucocorticoid receptors results in elevated basal luteinizing hormone release in male rats.","7700503","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8895366",1996,"Chronic brain glucocorticoid receptor blockade enhances the rise in circadian and stress-induced pituitary-adrenal activity.","8895366","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","9879980",1998,"Evaluation of RU28318 and RU40555 as selective mineralocorticoid receptor and glucocorticoid receptor antagonists, respectively: receptor measures and functional studies.","9879980","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8870033",1996,"Stimulatory vs. inhibitory effects of acute stress on plasma LH: differential effects of pretreatment with dexamethasone or the steroid receptor antagonist, RU 486.","8870033","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8911258",1996,"Glucocorticoid receptor antagonism by mifepristone alters phosphocreatine breakdown during sepsis.","8911258","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8344212",1993,"The steroid antagonist RU486 exerts different effects on the glucocorticoid and progesterone receptors.","8344212","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8383286",1993,"Synergistic induction of apoptosis with glucocorticoids and 3',5'-cyclic adenosine monophosphate reveals agonist activity by RU 486.","8383286","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8297920",1993,"Possible use of glucocorticoid receptor antagonists in the treatment of major depression: preliminary results using RU 486.","8297920","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8395651",1993,"Latent agonist activity of the steroid antagonist, RU486, is unmasked in cells treated with activators of protein kinase A.","8395651","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","7648494",1995,"[Effect of glucocorticoid receptor blockade on pulmonary and renal vascular permeability in scalded rats].","7648494","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","9824816",1998,"Inhibition of endometrial cancer cell lines by mifepristone (RU 486).","9824816","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","9017253",1996,"Protection against hypoxic-ischemic damage with corticosterone and dexamethasone: inhibition of effect by a glucocorticoid antagonist RU38486.","9017253","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","6238907",1984,"Inhibition of in vitro immunosuppressive effects of glucocorticosteroids by a competitive antagonist RU-486.","6238907","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8832229",1996,"Mifepristone prevents the expression of long-term behavioural sensitization to amphetamine.","8832229","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8442753",1993,"Effects of the glucocorticoid agonist, RU28362, and the antagonist RU486 on lung phosphatidylcholine and antioxidant enzyme development in the genetically obese Zucker rat.","8442753","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","7625744",1995,"The effects of glucocorticoid receptor (GR) blockade by RU 38486 and GR protection by GTT on hemorrhagic shock in rats.","7625744","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","9013504",1997,"Type II glucocorticoid receptor antagonists impair contextual but not auditory-cue fear conditioning in juvenile rats.","9013504","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","7573574",1995,"Comparison of effects of adrenalectomy and RU-486 in rats given a choice of maintenance diet and fat supplement.","7573574","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","7791348",1995,"Attenuation of the endotoxin-stimulated increase in hepatic amino acid transport with a glucocorticoid receptor antagonist.","7791348","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8461255",1993,"Binding of RU486 and deacylcortivazol to the glucocorticoid receptor is insensitive to sulfhydryl-modifying agents.","8461255","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8397827",1993,"Inhibition of gene expression by steroid hormone receptors via a negative glucocorticoid response element: evidence for the involvement of DNA-binding and agonistic effects of the antiglucocorticoid/antiprogestin RU486.","8397827","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","7957491",1994,"The in vivo effect of interleukin-1 beta on urea synthesis is mediated by glucocorticoids in rats.","7957491","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","7625725",1995,"Glucocorticoid antagonist RU 486 reverses agonist-induced apoptosis and c-myc repression in human leukemic CEM-C7 cells.","7625725","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","9075247",1997,"Glucocorticoid receptor agonist and antagonist administration into the basolateral but not central amygdala modulates memory storage.","9075247","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8092314",1994,"Central effects of glucocorticoid receptor antagonist RU-38486 on lipopolysaccharide and stress-induced fever.","8092314","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","6708516",1984,"Anti-steroid action in cultured L-929 mouse fibroblasts.","6708516","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","9528977",1998,"The antagonists RU486 and ZK98299 stimulate progesterone receptor binding to deoxyribonucleic acid in vitro and in vivo, but have distinct effects on receptor conformation.","9528977","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","7986150",1994,"Glucocorticoid receptor blockade reverses postinjury macrophage suppression.","7986150","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8099013",1993,"Killing of immature CD4+ CD8+ thymocytes in vivo by anti-CD3 or 5'-(N-ethyl)-carboxamide adenosine is blocked by glucocorticoid receptor antagonist RU-486.","8099013","Mifepristone","Receptors, Glucocorticoid"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L1284,L1284)","v":"Mifepristone"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M1284,M1284)","v":"Receptors, Glucocorticoid"},0,0,1,0,"NR3C1",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K1284,K1284)","v":"9458759"},1998,"Sleep-endocrine effects of mifepristone and megestrol acetate in healthy men.","9458759","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8888066",1996,"The antiglucocorticoid action of mifepristone.","8888066","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","9347404",1997,"RU-486 (Mifepristone) ameliorates diabetes but does not correct deficient beta-adrenergic signalling in adipocytes from mature C57BL/6J-ob/ob mice.","9347404","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","9316865",1997,"Effects of the glucocorticoid II receptor antagonist mifepristone on hypertension in the obese Zucker rat.","9316865","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","7852032",1994,"Alteration of structural order of human erythrocyte ghost membrane by glucocorticoids and the influence of the glucocorticoid receptor antagonist RU 486.","7852032","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","9284886",1997,"Effect of glucocorticoid receptor antagonist RU 38486 on acute glucocorticoid-induced insulin resistance in rat adipocytes.","9284886","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","9077590",1997,"Hippocampal mineralocorticoid, but not glucocorticoid, receptors modulate anxiety-like behavior in rats.","9077590","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","9182859",1997,"The hydrocortisone-induced transcriptional down-regulation of beta-galactoside alpha2,6-sialyltransferase in the small intestine of suckling rats is suppressed by mifepristone (RU-38.486).","9182859","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","7962467",1994,"Effects of D-ring substituents on antiprogestational (antagonist) and progestational (agonist) activity of 11 beta-aryl steroids.","7962467","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","7625728",1995,"The glucocorticoid receptor and RU 486 in man.","7625728","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8778154",1995,"Effects of the glucocorticoid antagonist RU486 in spontaneously hypertensive and Sprague Dawley rats.","8778154","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","6617759",1983,"Inhibition of glucocorticosteroid action in cultured L-929 mouse fibroblasts by RU 486, a new anti-glucocorticosteroid of high affinity for the glucocorticosteroid receptor.","6617759","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","6627946",1983,"Binding of the anti-progestin RU-486 to rat ovary steroid receptors.","6627946","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8013064",1994,"Effect of glucocorticoid receptor (GR) blockade on endotoxemia in rats.","8013064","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","7825904",1994,"The effects of RU 38486 and RU 28318 on energy balance of ovariectomized rats.","7825904","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,1,"NR3C1","8106625",1994,"Administration of RU 486 for 8 days in normal volunteers: antiglucocorticoid effect with no evidence of peripheral cortisol deprivation.","8106625","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8617314",1996,"Inhibition of I-Ad-, but not Db-restricted peptide-induced thymic apoptosis by glucocorticoid receptor antagonist RU486 in T cell receptor transgenic mice.","8617314","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","6708514",1984,"Effect of antiglucocorticoids on dexamethasone-induced inhibition of uridine incorporation and cell lysis in isolated mouse thymocytes.","6708514","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8140598",1994,"Synthesis of a fluorescent steroid derivative with high affinities for the glucocorticoid and progesterone receptors.","8140598","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","6708512",1984,"RU 38486: potent antiglucocorticoid activity correlated with strong binding to the cytosolic glucocorticoid receptor followed by an impaired activation.","6708512","Mifepristone","Receptors, Glucocorticoid"]
["Mifepristone","PPAR gamma",0,0,1,0,"PPARG","22674211",2012,"Medical management of Cushing's disease: what is the future?","22674211","Mifepristone","PPAR gamma"]
["Mirex","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2893471",1988,"Alterations in the hepatic glucocorticoid response to mirex treatment.","2893471","Mirex","Receptors, Glucocorticoid"]
["Mirex","Receptors, Glucocorticoid",0,0,1,1,"NR3C1","1673321",1991,"Regulation of glucocorticoid receptors during adaptive liver growth.","1673321","Mirex","Receptors, Glucocorticoid"]
["naphthalene","farnesoid X-activated receptor",0,0,1,0,"NR1H4","21256005",2011,"Conformationally constrained farnesoid X receptor (FXR) agonists: heteroaryl replacements of the naphthalene.","21256005","naphthalene","farnesoid X-activated receptor"]
["Nicotine","pregnane X receptor",0,0,1,0,"NR1I2","15364541",2004,"PXR (NR1I2): splice variants in human tissues, including brain, and identification of neurosteroids and nicotine as PXR activators.","15364541","Nicotine","pregnane X receptor"]
["Nicotine","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","15099681",2004,"(-)-nicotine ameliorates corticosterone's potentiation of N-methyl-d-aspartate receptor-mediated cornu ammonis 1 toxicity.","15099681","Nicotine","Receptors, Glucocorticoid"]
["Nicotine","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","22490492",2012,"Nicotine inhibits histone deacetylase 6 activity and chaperone-dependent activation of the glucocorticoid receptor in A549 cells.","22490492","Nicotine","Receptors, Glucocorticoid"]
["Nicotine","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","14604602",2004,"Nicotine withdrawal induces subsensitivity of hypothalamic-pituitary-adrenal axis to stress in rats: implications for precipitation of depression during smoking cessation.","14604602","Nicotine","Receptors, Glucocorticoid"]
["Nicotine","Nuclear Receptor Subfamily 4, Group A, Member 2",0,0,1,1,"NR4A2","21289608",2011,"Prenatal exposure to nicotine impairs performance of the 5-choice serial reaction time task in adult rats.","21289608","Nicotine","Nuclear Receptor Subfamily 4, Group A, Member 2"]
["Nicotine","PPAR alpha",0,0,1,0,"PPARA","22453137",2012,"Novel use of a lipid-lowering fibrate medication to prevent nicotine reward and relapse: preclinical findings.","22453137","Nicotine","PPAR alpha"]
["Nicotine","PPAR alpha",0,0,1,0,"PPARA","19091987",2008,"Endogenous fatty acid ethanolamides suppress nicotine-induced activation of mesolimbic dopamine neurons through nuclear receptors.","19091987","Nicotine","PPAR alpha"]
["Nicotine","PPAR alpha",0,0,1,0,"PPARA","20801430",2011,"Blockade of nicotine reward and reinstatement by activation of alpha-type peroxisome proliferator-activated receptors.","20801430","Nicotine","PPAR alpha"]
["Nicotine","PPAR alpha",0,0,1,0,"PPARA","20477753",2010,"Effects of fatty acid amide hydrolase inhibition on neuronal responses to nicotine, cocaine and morphine in the nucleus accumbens shell and ventral tegmental area: involvement of PPAR-alpha nuclear receptors.","20477753","Nicotine","PPAR alpha"]
["Nicotine","PPAR gamma",0,0,1,1,"PPARG","20715982",2010,"Evidence for in vivo nicotine-induced alveolar interstitial fibroblast-to-myofibroblast transdifferentiation.","20715982","Nicotine","PPAR gamma"]
["Nicotine","PPAR gamma",0,0,1,1,"PPARG","23002101",2013,"Sex-specific perinatal nicotine-induced asthma in rat offspring.","23002101","Nicotine","PPAR gamma"]
["Nicotine","PPAR gamma",0,0,1,0,"PPARG","21355041",2011,"PPAR? agonist rosiglitazone prevents perinatal nicotine exposure-induced asthma in rat offspring.","21355041","Nicotine","PPAR gamma"]
["Nicotine","PPAR gamma",0,0,1,1,"PPARG","19641967",2009,"The effects of smoking on the developing lung: insights from a biologic model for lung development, homeostasis, and repair.","19641967","Nicotine","PPAR gamma"]
["Nicotine","PPAR gamma",0,0,1,0,"PPARG","22425227",2012,"Nicotine modulates the immunological function of dendritic cells through peroxisome proliferator-activated receptor-? upregulation.","22425227","Nicotine","PPAR gamma"]
["Nicotine","PPAR gamma",0,0,1,1,"PPARG","17215434",2007,"In utero nicotine exposure alters fetal rat lung alveolar type II cell proliferation, differentiation, and metabolism.","17215434","Nicotine","PPAR gamma"]
["Nicotine","PPAR gamma",0,0,1,1,"PPARG","17765929",2007,"Quantification of PPAR-gamma protein in monocyte/macrophages from healthy smokers and non-smokers: a possible direct effect of nicotine.","17765929","Nicotine","PPAR gamma"]
["Nicotine","PPAR gamma",0,0,1,1,"PPARG","23911437",2013,"Perinatal nicotine-induced transgenerational asthma.","23911437","Nicotine","PPAR gamma"]
["Nicotine","PPAR gamma",0,0,1,1,"PPARG","23748423",2013,"Nicotine potentiates proatherogenic effects of oxLDL by stimulating and upregulating macrophage CD36 signaling.","23748423","Nicotine","PPAR gamma"]
["Nicotine","PPAR gamma",0,0,1,0,"PPARG","17401602",2007,"Reversal of nicotine-induced alveolar lipofibroblast-to-myofibroblast transdifferentiation by stimulants of parathyroid hormone-related protein signaling.","17401602","Nicotine","PPAR gamma"]
["Nicotine","PPAR gamma",0,0,1,1,"PPARG","23149826",2013,"Possible involvement of PPAR?-associated eNOS signaling activation in rosuvastatin-mediated prevention of nicotine-induced experimental vascular endothelial abnormalities.","23149826","Nicotine","PPAR gamma"]
["Nicotine","PPAR gamma",0,0,1,1,"PPARG","21133803",2011,"Mechanism for nicotine-induced up-regulation of Wnt signaling in human alveolar interstitial fibroblasts.","21133803","Nicotine","PPAR gamma"]
["nonylphenol","pregnane X receptor",0,0,0,0,"NR1I2","10707959",2000,"Endocrine disrupting chemicals, phthalic acid and nonylphenol, activate Pregnane X receptor-mediated transcription.","10707959","nonylphenol","pregnane X receptor"]
["nonylphenol","pregnane X receptor",0,0,0,0,"NR1I2","21376070",2011,"Nonylphenol-mediated CYP induction is PXR-dependent: The use of humanized mice and human hepatocytes suggests that hPXR is less sensitive than mouse PXR to nonylphenol treatment.","21376070","nonylphenol","pregnane X receptor"]
["nonylphenol","pregnane X receptor",0,0,0,1,"NR1I2","17483497",2007,"The environmental estrogen, nonylphenol, activates the constitutive androstane receptor.","17483497","nonylphenol","pregnane X receptor"]
["nonylphenol","constitutive androstane receptor",0,0,0,1,"NR1I3","17483497",2007,"The environmental estrogen, nonylphenol, activates the constitutive androstane receptor.","17483497","nonylphenol","constitutive androstane receptor"]
["nonylphenol","PPAR alpha",0,0,0,1,"PPARA","21914226",2011,"miRNA regulation of cytotoxic effects in mouse Sertoli cells exposed to nonylphenol.","21914226","nonylphenol","PPAR alpha"]
["o,p'-DDT","pregnane X receptor",0,0,1,1,"NR1I2","17984292",2008,"o,p'-DDT elicits PXR/CAR-, not ER-, mediated responses in the immature ovariectomized rat liver.","17984292","o,p'-DDT","pregnane X receptor"]
["o,p'-DDT","pregnane X receptor",0,0,1,0,"NR1I2","17035600",2007,"Pregnane X receptor-dependent induction of the CYP3A4 gene by o,p'-1,1,1,-trichloro-2,2-bis (p-chlorophenyl)ethane.","17035600","o,p'-DDT","pregnane X receptor"]
["o,p'-DDT","constitutive androstane receptor",0,0,1,1,"NR1I3","17984292",2008,"o,p'-DDT elicits PXR/CAR-, not ER-, mediated responses in the immature ovariectomized rat liver.","17984292","o,p'-DDT","constitutive androstane receptor"]
["Paraquat","PPAR gamma",1,0,0,1,"PPARG","23933652",2013,"Inhibitory effects of rosiglitazone on paraquat-induced acute lung injury in rats.","23933652","Paraquat","PPAR gamma"]
["perfluorooctane sulfonic acid","pregnane X receptor",0,0,1,1,"NR1I2","19162173",2009,"Evidence for the involvement of xenobiotic-responsive nuclear receptors in transcriptional effects upon perfluoroalkyl acid exposure in diverse species.","19162173","perfluorooctane sulfonic acid","pregnane X receptor"]
["perfluorooctane sulfonic acid","pregnane X receptor",0,0,1,1,"NR1I2","22245121",2012,"Hepatocellular hypertrophy and cell proliferation in Sprague-Dawley rats from dietary exposure to potassium perfluorooctanesulfonate results from increased expression of xenosensor nuclear receptors PPAR? and CAR/PXR.","22245121","perfluorooctane sulfonic acid","pregnane X receptor"]
["perfluorooctane sulfonic acid","pregnane X receptor",0,0,1,1,"NR1I2","22239858",2012,"Evaluation of hepatic and thyroid responses in male Sprague Dawley rats for up to eighty-four days following seven days of dietary exposure to potassium perfluorooctanesulfonate.","22239858","perfluorooctane sulfonic acid","pregnane X receptor"]
["perfluorooctane sulfonic acid","pregnane X receptor",0,0,1,0,"NR1I2","22197512",2012,"Exposure and effective dose biomarkers for perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) in infertile subjects: preliminary results of the PREVIENI project.","22197512","perfluorooctane sulfonic acid","pregnane X receptor"]
["perfluorooctane sulfonic acid","pregnane X receptor",0,0,1,0,"NR1I2","21354591",2011,"Tissue bioaccumulation patterns, xenobiotic biotransformation and steroid hormone levels in Atlantic salmon (Salmo salar) fed a diet containing perfluoroactane sulfonic or perfluorooctane carboxylic acids.","21354591","perfluorooctane sulfonic acid","pregnane X receptor"]
["perfluorooctane sulfonic acid","constitutive androstane receptor",0,0,1,1,"NR1I3","19162173",2009,"Evidence for the involvement of xenobiotic-responsive nuclear receptors in transcriptional effects upon perfluoroalkyl acid exposure in diverse species.","19162173","perfluorooctane sulfonic acid","constitutive androstane receptor"]
["perfluorooctane sulfonic acid","constitutive androstane receptor",0,0,1,1,"NR1I3","22245121",2012,"Hepatocellular hypertrophy and cell proliferation in Sprague-Dawley rats from dietary exposure to potassium perfluorooctanesulfonate results from increased expression of xenosensor nuclear receptors PPAR? and CAR/PXR.","22245121","perfluorooctane sulfonic acid","constitutive androstane receptor"]
["perfluorooctane sulfonic acid","constitutive androstane receptor",0,0,1,1,"NR1I3","22239858",2012,"Evaluation of hepatic and thyroid responses in male Sprague Dawley rats for up to eighty-four days following seven days of dietary exposure to potassium perfluorooctanesulfonate.","22239858","perfluorooctane sulfonic acid","constitutive androstane receptor"]
["perfluorooctane sulfonic acid","PPAR alpha",0,0,1,1,"PPARA","18802816",2009,"Immunotoxicity of perfluorooctanoic acid and perfluorooctane sulfonate and the role of peroxisome proliferator-activated receptor alpha.","18802816","perfluorooctane sulfonic acid","PPAR alpha"]
["perfluorooctane sulfonic acid","PPAR alpha",0,0,1,1,"PPARA","18565798",2008,"Exposure to perfluorooctane sulfonate or fenofibrate causes PPAR-alpha dependent transcriptional responses in chicken embryo hepatocytes.","18565798","perfluorooctane sulfonic acid","PPAR alpha"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L1348,L1348)","v":"perfluorooctane sulfonic acid"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M1348,M1348)","v":"PPAR alpha"},0,0,1,1,"PPARA",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K1348,K1348)","v":"21075133"},2011,"In vitro evaluation of the immunotoxic potential of perfluorinated compounds (PFCs).","21075133","perfluorooctane sulfonic acid","PPAR alpha"]
["perfluorooctane sulfonic acid","PPAR alpha",0,0,1,1,"PPARA","15071170",2004,"trans-activation of PPARalpha and induction of PPARalpha target genes by perfluorooctane-based chemicals.","15071170","perfluorooctane sulfonic acid","PPAR alpha"]
["perfluorooctane sulfonic acid","PPAR alpha",0,0,1,1,"PPARA","18595657",2009,"Developmental toxicity of perfluorooctane sulfonate (PFOS) is not dependent on expression of peroxisome proliferator activated receptor-alpha (PPAR alpha) in the mouse.","18595657","perfluorooctane sulfonic acid","PPAR alpha"]
["perfluorooctane sulfonic acid","PPAR alpha",0,0,1,1,"PPARA","22465071",2012,"Transcription of genes involved in fat metabolism in chicken embryos exposed to the peroxisome proliferator-activated receptor alpha (PPAR?) agonist GW7647 or to perfluorooctane sulfonate (PFOS) or perfluorooctanoic acid (PFOA).","22465071","perfluorooctane sulfonic acid","PPAR alpha"]
["perfluorooctane sulfonic acid","PPAR alpha",0,0,1,1,"PPARA","21571052",2011,"Modulation of dietary fat on the toxicological effects in thymus and spleen in BALB/c mice exposed to perfluorooctane sulfonate.","21571052","perfluorooctane sulfonic acid","PPAR alpha"]
["perfluorooctane sulfonic acid","PPAR alpha",0,0,1,1,"PPARA","18692542",2008,"Perfluorooctane sulfonate-induced changes in fetal rat liver gene expression.","18692542","perfluorooctane sulfonic acid","PPAR alpha"]
["perfluorooctane sulfonic acid","PPAR alpha",0,0,1,1,"PPARA","17047030",2007,"Activation of mouse and human peroxisome proliferator-activated receptors (alpha, beta/delta, gamma) by perfluorooctanoic acid and perfluorooctane sulfonate.","17047030","perfluorooctane sulfonic acid","PPAR alpha"]
["perfluorooctane sulfonic acid","PPAR alpha",0,0,1,1,"PPARA","17544559",2007,"Effects of perfluorooctane sulfonate on tracheal ciliary beating frequency in mice.","17544559","perfluorooctane sulfonic acid","PPAR alpha"]
["perfluorooctane sulfonic acid","PPAR alpha",0,0,1,1,"PPARA","19561327",2009,"Does exposure to perfluoroalkyl acids present a risk to human health?","19561327","perfluorooctane sulfonic acid","PPAR alpha"]
["perfluorooctane sulfonic acid","PPAR alpha",0,0,1,0,"PPARA","21345559",2011,"A rapid and high-throughput quantum dots bioassay for monitoring of perfluorooctane sulfonate in environmental water samples.","21345559","perfluorooctane sulfonic acid","PPAR alpha"]
["perfluorooctane sulfonic acid","PPAR alpha",0,0,1,1,"PPARA","22239858",2012,"Evaluation of hepatic and thyroid responses in male Sprague Dawley rats for up to eighty-four days following seven days of dietary exposure to potassium perfluorooctanesulfonate.","22239858","perfluorooctane sulfonic acid","PPAR alpha"]
["perfluorooctane sulfonic acid","PPAR alpha",0,0,1,1,"PPARA","22245121",2012,"Hepatocellular hypertrophy and cell proliferation in Sprague-Dawley rats from dietary exposure to potassium perfluorooctanesulfonate results from increased expression of xenosensor nuclear receptors PPAR? and CAR/PXR.","22245121","perfluorooctane sulfonic acid","PPAR alpha"]
["perfluorooctane sulfonic acid","PPAR alpha",0,0,1,1,"PPARA","19101656",2009,"Perfluorooctane sulfonate (PFOS) toxicity in domestic chicken (Gallus gallus domesticus) embryos in the absence of effects on peroxisome proliferator activated receptor alpha (PPARalpha)-regulated genes.","19101656","perfluorooctane sulfonic acid","PPAR alpha"]
["perfluorooctane sulfonic acid","PPAR alpha",0,0,1,1,"PPARA","19464571",2009,"The atrophy and changes in the cellular compositions of the thymus and spleen observed in mice subjected to short-term exposure to perfluorooctanesulfonate are high-dose phenomena mediated in part by peroxisome proliferator-activated receptor-alpha (PPARalpha).","19464571","perfluorooctane sulfonic acid","PPAR alpha"]
["perfluorooctane sulfonic acid","PPAR gamma",0,0,1,1,"PPARG","23500012",2013,"Perfluorooctane sulfonate induces neuronal and oligodendrocytic differentiation in neural stem cells and alters the expression of PPAR? in vitro and in vivo.","23500012","perfluorooctane sulfonic acid","PPAR gamma"]
["perfluorooctane sulfonic acid","PPAR gamma",0,0,1,1,"PPARG","17047030",2007,"Activation of mouse and human peroxisome proliferator-activated receptors (alpha, beta/delta, gamma) by perfluorooctanoic acid and perfluorooctane sulfonate.","17047030","perfluorooctane sulfonic acid","PPAR gamma"]
["perfluorooctanoic acid","farnesoid X-activated receptor",1,0,1,1,"NR1H4","18703564",2008,"Critical role of PPAR-alpha in perfluorooctanoic acid- and perfluorodecanoic acid-induced downregulation of Oatp uptake transporters in mouse livers.","18703564","perfluorooctanoic acid","farnesoid X-activated receptor"]
["perfluorooctanoic acid","farnesoid X-activated receptor",1,0,1,1,"NR1H4","18648086",2008,"Perfluorocarboxylic acids induce cytochrome P450 enzymes in mouse liver through activation of PPAR-alpha and CAR transcription factors.","18648086","perfluorooctanoic acid","farnesoid X-activated receptor"]
["perfluorooctanoic acid","pregnane X receptor",1,0,1,0,"NR1I2","21354591",2011,"Tissue bioaccumulation patterns, xenobiotic biotransformation and steroid hormone levels in Atlantic salmon (Salmo salar) fed a diet containing perfluoroactane sulfonic or perfluorooctane carboxylic acids.","21354591","perfluorooctanoic acid","pregnane X receptor"]
["perfluorooctanoic acid","pregnane X receptor",1,0,1,1,"NR1I2","18703564",2008,"Critical role of PPAR-alpha in perfluorooctanoic acid- and perfluorodecanoic acid-induced downregulation of Oatp uptake transporters in mouse livers.","18703564","perfluorooctanoic acid","pregnane X receptor"]
["perfluorooctanoic acid","pregnane X receptor",1,0,1,0,"NR1I2","18508136",2008,"Molecular characterization of cytochrome P450 1A and 3A and the effects of perfluorooctanoic acid on their mRNA levels in rare minnow (Gobiocypris rarus) gills.","18508136","perfluorooctanoic acid","pregnane X receptor"]
["perfluorooctanoic acid","pregnane X receptor",1,0,1,1,"NR1I2","20614104",2010,"Hepatocellular hypertrophy and cell proliferation in Sprague-Dawley rats following dietary exposure to ammonium perfluorooctanoate occurs through increased activation of the xenosensor nuclear receptors PPAR? and CAR/PXR.","20614104","perfluorooctanoic acid","pregnane X receptor"]
["perfluorooctanoic acid","pregnane X receptor",1,0,1,0,"NR1I2","22197512",2012,"Exposure and effective dose biomarkers for perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) in infertile subjects: preliminary results of the PREVIENI project.","22197512","perfluorooctanoic acid","pregnane X receptor"]
["perfluorooctanoic acid","pregnane X receptor",1,0,1,1,"NR1I2","19162173",2009,"Evidence for the involvement of xenobiotic-responsive nuclear receptors in transcriptional effects upon perfluoroalkyl acid exposure in diverse species.","19162173","perfluorooctanoic acid","pregnane X receptor"]
["perfluorooctanoic acid","pregnane X receptor",1,0,1,1,"NR1I2","18648086",2008,"Perfluorocarboxylic acids induce cytochrome P450 enzymes in mouse liver through activation of PPAR-alpha and CAR transcription factors.","18648086","perfluorooctanoic acid","pregnane X receptor"]
["perfluorooctanoic acid","constitutive androstane receptor",1,0,1,1,"NR1I3","18281256",2008,"Toxicogenomic dissection of the perfluorooctanoic acid transcript profile in mouse liver: evidence for the involvement of nuclear receptors PPAR alpha and CAR.","18281256","perfluorooctanoic acid","constitutive androstane receptor"]
["perfluorooctanoic acid","constitutive androstane receptor",1,0,1,1,"NR1I3","19162173",2009,"Evidence for the involvement of xenobiotic-responsive nuclear receptors in transcriptional effects upon perfluoroalkyl acid exposure in diverse species.","19162173","perfluorooctanoic acid","constitutive androstane receptor"]
["perfluorooctanoic acid","constitutive androstane receptor",1,0,1,1,"NR1I3","18703564",2008,"Critical role of PPAR-alpha in perfluorooctanoic acid- and perfluorodecanoic acid-induced downregulation of Oatp uptake transporters in mouse livers.","18703564","perfluorooctanoic acid","constitutive androstane receptor"]
["perfluorooctanoic acid","constitutive androstane receptor",1,0,1,1,"NR1I3","18648086",2008,"Perfluorocarboxylic acids induce cytochrome P450 enzymes in mouse liver through activation of PPAR-alpha and CAR transcription factors.","18648086","perfluorooctanoic acid","constitutive androstane receptor"]
["perfluorooctanoic acid","constitutive androstane receptor",1,0,1,1,"NR1I3","20614104",2010,"Hepatocellular hypertrophy and cell proliferation in Sprague-Dawley rats following dietary exposure to ammonium perfluorooctanoate occurs through increased activation of the xenosensor nuclear receptors PPAR? and CAR/PXR.","20614104","perfluorooctanoic acid","constitutive androstane receptor"]
["perfluorooctanoic acid","PPAR alpha",1,0,1,1,"PPARA","18281256",2008,"Toxicogenomic dissection of the perfluorooctanoic acid transcript profile in mouse liver: evidence for the involvement of nuclear receptors PPAR alpha and CAR.","18281256","perfluorooctanoic acid","PPAR alpha"]
["perfluorooctanoic acid","PPAR alpha",1,0,1,0,"PPARA","18182248",2008,"Anti-inflammatory actions of perfluorooctanoic acid and peroxisome proliferator-activated receptors (PPAR) alpha and gamma in experimental acute pancreatitis.","18182248","perfluorooctanoic acid","PPAR alpha"]
["perfluorooctanoic acid","PPAR alpha",1,0,1,1,"PPARA","23143925",2013,"A species difference in the peroxisome proliferator-activated receptor ?-dependent response to the developmental effects of perfluorooctanoic acid.","23143925","perfluorooctanoic acid","PPAR alpha"]
["perfluorooctanoic acid","PPAR alpha",1,0,1,1,"PPARA","20118188",2010,"Perfluorooctanoic acid effects on steroid hormone and growth factor levels mediate stimulation of peripubertal mammary gland development in C57BL/6 mice.","20118188","perfluorooctanoic acid","PPAR alpha"]
["perfluorooctanoic acid","PPAR alpha",1,0,1,1,"PPARA","18648086",2008,"Perfluorocarboxylic acids induce cytochrome P450 enzymes in mouse liver through activation of PPAR-alpha and CAR transcription factors.","18648086","perfluorooctanoic acid","PPAR alpha"]
["perfluorooctanoic acid","PPAR alpha",1,0,1,1,"PPARA","19561327",2009,"Does exposure to perfluoroalkyl acids present a risk to human health?","19561327","perfluorooctanoic acid","PPAR alpha"]
["perfluorooctanoic acid","PPAR alpha",1,0,1,1,"PPARA","18467680",2008,"Comparative hepatic effects of perfluorooctanoic acid and WY 14,643 in PPAR-alpha knockout and wild-type mice.","18467680","perfluorooctanoic acid","PPAR alpha"]
["perfluorooctanoic acid","PPAR alpha",1,0,1,1,"PPARA","18802816",2009,"Immunotoxicity of perfluorooctanoic acid and perfluorooctane sulfonate and the role of peroxisome proliferator-activated receptor alpha.","18802816","perfluorooctanoic acid","PPAR alpha"]
["perfluorooctanoic acid","PPAR alpha",1,0,1,1,"PPARA","18703564",2008,"Critical role of PPAR-alpha in perfluorooctanoic acid- and perfluorodecanoic acid-induced downregulation of Oatp uptake transporters in mouse livers.","18703564","perfluorooctanoic acid","PPAR alpha"]
["perfluorooctanoic acid","PPAR alpha",1,0,1,1,"PPARA","21381677",2011,"Transactivation potencies of the Baikal seal (Pusa sibirica) peroxisome proliferator-activated receptor ? by perfluoroalkyl carboxylates and sulfonates: estimation of PFOA induction equivalency factors.","21381677","perfluorooctanoic acid","PPAR alpha"]
["perfluorooctanoic acid","PPAR alpha",1,0,1,1,"PPARA","22465071",2012,"Transcription of genes involved in fat metabolism in chicken embryos exposed to the peroxisome proliferator-activated receptor alpha (PPAR?) agonist GW7647 or to perfluorooctane sulfonate (PFOS) or perfluorooctanoic acid (PFOA).","22465071","perfluorooctanoic acid","PPAR alpha"]
["perfluorooctanoic acid","PPAR alpha",1,0,1,1,"PPARA","21712084",2011,"Ammonium perfluorooctanoate may cause testosterone reduction by adversely affecting testis in relation to PPAR?.","21712084","perfluorooctanoic acid","PPAR alpha"]
["perfluorooctanoic acid","PPAR alpha",1,0,1,1,"PPARA","20614104",2010,"Hepatocellular hypertrophy and cell proliferation in Sprague-Dawley rats following dietary exposure to ammonium perfluorooctanoate occurs through increased activation of the xenosensor nuclear receptors PPAR? and CAR/PXR.","20614104","perfluorooctanoic acid","PPAR alpha"]
["perfluorooctanoic acid","PPAR alpha",1,0,1,1,"PPARA","17488742",2007,"Perfluorooctanoic acid induced developmental toxicity in the mouse is dependent on expression of peroxisome proliferator activated receptor-alpha.","17488742","perfluorooctanoic acid","PPAR alpha"]
["perfluorooctanoic acid","PPAR alpha",1,0,1,1,"PPARA","23978332",2013,"Perfluorooctanoate suppresses spheroid attachment on endometrial epithelial cells through peroxisome proliferator-activated receptor alpha and down-regulation of Wnt signaling.","23978332","perfluorooctanoic acid","PPAR alpha"]
["perfluorooctanoic acid","PPAR alpha",1,0,1,1,"PPARA","21628884",2011,"Effects of perfluorinated fatty acids with different carbon chain length on fatty acid profiles of hepatic lipids in mice.","21628884","perfluorooctanoic acid","PPAR alpha"]
["perfluorooctanoic acid","PPAR alpha",1,0,1,1,"PPARA","23941634",2013,"Perfluorooctanoic acid induced-developmental cardiotoxicity: are peroxisome proliferator activated receptor ? (PPAR?) and bone morphorgenic protein 2 (BMP2) pathways involved?","23941634","perfluorooctanoic acid","PPAR alpha"]
["perfluorooctanoic acid","PPAR alpha",1,0,1,1,"PPARA","18757529",2008,"Nrf2- and PPAR alpha-mediated regulation of hepatic Mrp transporters after exposure to perfluorooctanoic acid and perfluorodecanoic acid.","18757529","perfluorooctanoic acid","PPAR alpha"]
["perfluorooctanoic acid","PPAR alpha",1,0,1,1,"PPARA","22414604",2012,"Perfluorooctanoic acid effects on ovaries mediate its inhibition of peripubertal mammary gland development in Balb/c and C57Bl/6 mice.","22414604","perfluorooctanoic acid","PPAR alpha"]
["perfluorooctanoic acid","PPAR alpha",1,0,1,1,"PPARA","20452409",2010,"Urea cycle gene expression is suppressed by PFOA treatment in rats.","20452409","perfluorooctanoic acid","PPAR alpha"]
["perfluorooctanoic acid","PPAR alpha",1,0,1,1,"PPARA","19464571",2009,"The atrophy and changes in the cellular compositions of the thymus and spleen observed in mice subjected to short-term exposure to perfluorooctanesulfonate are high-dose phenomena mediated in part by peroxisome proliferator-activated receptor-alpha (PPARalpha).","19464571","perfluorooctanoic acid","PPAR alpha"]
["perfluorooctanoic acid","PPAR alpha",1,0,1,1,"PPARA","21075133",2011,"In vitro evaluation of the immunotoxic potential of perfluorinated compounds (PFCs).","21075133","perfluorooctanoic acid","PPAR alpha"]
["perfluorooctanoic acid","PPAR alpha",1,0,1,1,"PPARA","18559402",2008,"Evaluation of the immune system in rats and mice administered linear ammonium perfluorooctanoate.","18559402","perfluorooctanoic acid","PPAR alpha"]
["perfluorooctanoic acid","PPAR alpha",1,0,1,1,"PPARA","24374136",2014,"Evaluating the additivity of perfluoroalkyl acids in binary combinations on peroxisome proliferator-activated receptor-? activation.","24374136","perfluorooctanoic acid","PPAR alpha"]
["perfluorooctanoic acid","PPAR alpha",1,0,1,1,"PPARA","17047030",2007,"Activation of mouse and human peroxisome proliferator-activated receptors (alpha, beta/delta, gamma) by perfluorooctanoic acid and perfluorooctane sulfonate.","17047030","perfluorooctanoic acid","PPAR alpha"]
["perfluorooctanoic acid","PPAR alpha",1,0,1,1,"PPARA","18467677",2008,"Gene profiling in the livers of wild-type and PPARalpha-null mice exposed to perfluorooctanoic acid.","18467677","perfluorooctanoic acid","PPAR alpha"]
["perfluorooctanoic acid","PPAR alpha",1,0,1,1,"PPARA","19751795",2009,"Microgram-order ammonium perfluorooctanoate may activate mouse peroxisome proliferator-activated receptor alpha, but not human PPARalpha.","19751795","perfluorooctanoic acid","PPAR alpha"]
["perfluorooctanoic acid","PPAR alpha",1,0,1,1,"PPARA","23391484",2013,"In vitro toxicological characterization of perfluorinated carboxylic acids with different carbon chain lengths.","23391484","perfluorooctanoic acid","PPAR alpha"]
["perfluorooctanoic acid","PPAR alpha",1,0,1,1,"PPARA","19800026",2010,"The identification of apolipoprotein genes in rare minnow (Gobiocypris rarus) and their expression following perfluorooctanoic acid exposure.","19800026","perfluorooctanoic acid","PPAR alpha"]
["perfluorooctanoic acid","PPAR alpha",1,0,1,1,"PPARA","23435180",2013,"Hepatic and renal Bcrp transporter expression in mice treated with perfluorooctanoic acid.","23435180","perfluorooctanoic acid","PPAR alpha"]
["perfluorooctanoic acid","PPAR alpha",1,0,1,1,"PPARA","18360689",2008,"The ubiquitous environmental pollutant perfluorooctanoicacid inhibits feeding behavior via peroxisome proliferator-activated receptor-alpha.","18360689","perfluorooctanoic acid","PPAR alpha"]
["perfluorooctanoic acid","PPAR alpha",1,0,1,1,"PPARA","20875479",2011,"Toxicological evaluation of ammonium 4,8-dioxa-3H-perfluorononanoate, a new emulsifier to replace ammonium perfluorooctanoate in fluoropolymer manufacturing.","20875479","perfluorooctanoic acid","PPAR alpha"]
["perfluorooctanoic acid","PPAR gamma",1,0,1,1,"PPARG","19800026",2010,"The identification of apolipoprotein genes in rare minnow (Gobiocypris rarus) and their expression following perfluorooctanoic acid exposure.","19800026","perfluorooctanoic acid","PPAR gamma"]
["perfluorooctanoic acid","PPAR gamma",1,0,1,0,"PPARG","18182248",2008,"Anti-inflammatory actions of perfluorooctanoic acid and peroxisome proliferator-activated receptors (PPAR) alpha and gamma in experimental acute pancreatitis.","18182248","perfluorooctanoic acid","PPAR gamma"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L1412,L1412)","v":"perfluorooctanoic acid"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M1412,M1412)","v":"PPAR gamma"},1,0,1,1,"PPARG",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K1412,K1412)","v":"17047030"},2007,"Activation of mouse and human peroxisome proliferator-activated receptors (alpha, beta/delta, gamma) by perfluorooctanoic acid and perfluorooctane sulfonate.","17047030","perfluorooctanoic acid","PPAR gamma"]
["perfluorooctanoic acid","PPAR gamma",1,0,1,0,"PPARG","19616056",2009,"Perfluorooctanoic acid stimulated mitochondrial biogenesis and gene transcription in rats.","19616056","perfluorooctanoic acid","PPAR gamma"]
["perfluorooctanoic acid","PPAR gamma",1,0,1,1,"PPARG","23391484",2013,"In vitro toxicological characterization of perfluorinated carboxylic acids with different carbon chain lengths.","23391484","perfluorooctanoic acid","PPAR gamma"]
["Permethrin","pregnane X receptor",0,0,0,1,"NR1I2","19326768",2008,"Pyrethroids: cytotoxicity and induction of CYP isoforms in human hepatocytes.","19326768","Permethrin","pregnane X receptor"]
["Permethrin","Nuclear Receptor Subfamily 4, Group A, Member 2",0,0,0,1,"NR4A2","25048945",2014,"Effect of 17?-estradiol on striatal dopaminergic transmission induced by permethrin in early childhood rats.","25048945","Permethrin","Nuclear Receptor Subfamily 4, Group A, Member 2"]
["Permethrin","Nuclear Receptor Subfamily 4, Group A, Member 2",0,0,0,1,"NR4A2","22804098",2012,"Leukocyte Nurr1 as peripheral biomarker of early-life environmental exposure to permethrin insecticide.","22804098","Permethrin","Nuclear Receptor Subfamily 4, Group A, Member 2"]
["Permethrin","Nuclear Receptor Subfamily 4, Group A, Member 2",0,0,0,1,"NR4A2","23566817",2013,"Early life permethrin exposure induces long-term brain changes in Nurr1, NF-kB and Nrf-2.","23566817","Permethrin","Nuclear Receptor Subfamily 4, Group A, Member 2"]
["Permethrin","Nuclear Receptor Subfamily 4, Group A, Member 2",0,0,0,1,"NR4A2","22056222",2012,"The impact of early life permethrin exposure on development of neurodegeneration in adulthood.","22056222","Permethrin","Nuclear Receptor Subfamily 4, Group A, Member 2"]
["Phenobarbital","pregnane X receptor",0,0,0,1,"NR1I2","20403969",2010,"Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo.","20403969","Phenobarbital","pregnane X receptor"]
["Phenobarbital","pregnane X receptor",0,0,0,0,"NR1I2","16799975",2006,"Phenobarbital regulates nuclear expression of HNF-4alpha in mouse and rat hepatocytes independent of CAR and PXR.","16799975","Phenobarbital","pregnane X receptor"]
["Phenobarbital","pregnane X receptor",0,0,0,0,"NR1I2","14600250",2004,"Induction of human CYP2C9 by rifampicin, hyperforin, and phenobarbital is mediated by the pregnane X receptor.","14600250","Phenobarbital","pregnane X receptor"]
["Phenobarbital","pregnane X receptor",0,0,0,1,"NR1I2","19286836",2009,"Regulation of human vitamin D(3) 25-hydroxylases in dermal fibroblasts and prostate cancer LNCaP cells.","19286836","Phenobarbital","pregnane X receptor"]
["Phenobarbital","pregnane X receptor",0,0,0,0,"NR1I2","15496645",2004,"Induction of CYP3A4 by efavirenz in primary human hepatocytes: comparison with rifampin and phenobarbital.","15496645","Phenobarbital","pregnane X receptor"]
["Phenobarbital","pregnane X receptor",0,0,0,0,"NR1I2","11455014",2001,"The antiglucocorticoid RU486 inhibits phenobarbital induction of the chicken CYP2H1 gene in primary hepatocytes.","11455014","Phenobarbital","pregnane X receptor"]
["Phenobarbital","pregnane X receptor",0,0,0,0,"NR1I2","19708687",2009,"Transcriptional activation of PPARalpha by phenobarbital in the absence of CAR and PXR.","19708687","Phenobarbital","pregnane X receptor"]
["Phenobarbital","pregnane X receptor",0,0,0,0,"NR1I2","20488228",2010,"Lack of P-glycoprotein induction by rifampicin and phenobarbital in human lymphocytes.","20488228","Phenobarbital","pregnane X receptor"]
["Phenobarbital","pregnane X receptor",0,0,0,0,"NR1I2","19541828",2009,"Genetic polymorphisms in the TATA box and upstream phenobarbital-responsive enhancer module of the UGT1A1 promoter have combined effects on UDP-glucuronosyltransferase 1A1 transcription mediated by constitutive androstane receptor, pregnane X receptor, or glucocorticoid receptor in human liver.","19541828","Phenobarbital","pregnane X receptor"]
["Phenobarbital","pregnane X receptor",0,0,0,1,"NR1I2","24180433",2014,"Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator.","24180433","Phenobarbital","pregnane X receptor"]
["Phenobarbital","pregnane X receptor",0,0,0,0,"NR1I2","16936065",2006,"Phenytoin induction of the cyp2c37 gene is mediated by the constitutive androstane receptor.","16936065","Phenobarbital","pregnane X receptor"]
["Phenobarbital","pregnane X receptor",0,0,0,0,"NR1I2","17161434",2007,"Expression, microsomal and mitochondrial activities of cytochrome P450 enzymes in brain regions from control and phenobarbital-treated rabbits.","17161434","Phenobarbital","pregnane X receptor"]
["Phenobarbital","pregnane X receptor",0,0,0,0,"NR1I2","20645062",2010,"Metabonomic studies on human hepatocyte in primary culture.","20645062","Phenobarbital","pregnane X receptor"]
["Phenobarbital","pregnane X receptor",0,0,0,0,"NR1I2","20955791",2011,"Transport of 5,5-diphenylbarbituric acid and its precursors and their effect on P-gp, MRP2 and CYP3A4 in Caco-2 and LS180 cells.","20955791","Phenobarbital","pregnane X receptor"]
["Phenobarbital","constitutive androstane receptor",0,0,0,1,"NR1I3","24675475",2014,"Phenobarbital and propiconazole toxicogenomic profiles in mice show major similarities consistent with the key role that constitutive androstane receptor (CAR) activation plays in their mode of action.","24675475","Phenobarbital","constitutive androstane receptor"]
["Phenobarbital","constitutive androstane receptor",0,0,0,1,"NR1I3","24180433",2014,"Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator.","24180433","Phenobarbital","constitutive androstane receptor"]
["Phenobarbital","constitutive androstane receptor",0,0,0,0,"NR1I3","10993889",2000,"Mutational analysis of the CYP2B2 phenobarbital response unit and inhibitory effect of the constitutive androstane receptor on phenobarbital responsiveness.","10993889","Phenobarbital","constitutive androstane receptor"]
["Phenobarbital","constitutive androstane receptor",0,0,0,0,"NR1I3","12130690",2002,"Modulation of mouse and human phenobarbital-responsive enhancer module by nuclear receptors.","12130690","Phenobarbital","constitutive androstane receptor"]
["Phenobarbital","constitutive androstane receptor",0,0,0,0,"NR1I3","15953603",2005,"Impaired nuclear translocation of CAR in hepatic preneoplastic lesions: association with an attenuated CYP2B induction by phenobarbital.","15953603","Phenobarbital","constitutive androstane receptor"]
["Phenobarbital","constitutive androstane receptor",0,0,0,0,"NR1I3","11160864",2001,"Nuclear receptor CAR as a regulatory factor for the sexually dimorphic induction of CYB2B1 gene by phenobarbital in rat livers.","11160864","Phenobarbital","constitutive androstane receptor"]
["Phenobarbital","constitutive androstane receptor",0,0,0,0,"NR1I3","19233941",2009,"Multiple genes exhibit phenobarbital-induced constitutive active/androstane receptor-mediated DNA methylation changes during liver tumorigenesis and in liver tumors.","19233941","Phenobarbital","constitutive androstane receptor"]
["Phenobarbital","constitutive androstane receptor",0,0,0,0,"NR1I3","11027630",2000,"Phenobarbital-elicited activation of nuclear receptor CAR in induction of cytochrome P450 genes.","11027630","Phenobarbital","constitutive androstane receptor"]
["Phenobarbital","constitutive androstane receptor",0,0,0,0,"NR1I3","20645062",2010,"Metabonomic studies on human hepatocyte in primary culture.","20645062","Phenobarbital","constitutive androstane receptor"]
["Phenobarbital","constitutive androstane receptor",0,0,0,0,"NR1I3","11027641",2000,"Suppression of the expression of the CYP2B1/2 gene by retinoic acids.","11027641","Phenobarbital","constitutive androstane receptor"]
["Phenobarbital","constitutive androstane receptor",0,0,0,1,"NR1I3","21445586",2011,"Suppressive effect of enzymatically modified isoquercitrin on phenobarbital-induced liver tumor promotion in rats.","21445586","Phenobarbital","constitutive androstane receptor"]
["Phenobarbital","constitutive androstane receptor",0,0,0,0,"NR1I3","17904175",2007,"DHA down-regulates phenobarbital-induced cytochrome P450 2B1 gene expression in rat primary hepatocytes by attenuating CAR translocation.","17904175","Phenobarbital","constitutive androstane receptor"]
["Phenobarbital","constitutive androstane receptor",0,0,0,1,"NR1I3","20816995",2010,"The increased CAR-dependent metabolism of thyroid hormones in mice with high cancer susceptibility.","20816995","Phenobarbital","constitutive androstane receptor"]
["Phenobarbital","constitutive androstane receptor",0,0,0,1,"NR1I3","24449422",2014,"Dose-response modeling of early molecular and cellular key events in the CAR-mediated hepatocarcinogenesis pathway.","24449422","Phenobarbital","constitutive androstane receptor"]
["Phenobarbital","constitutive androstane receptor",0,0,0,0,"NR1I3","11033069",2000,"Induction of drug metabolism by nuclear receptor CAR: molecular mechanisms and implications for drug research.","11033069","Phenobarbital","constitutive androstane receptor"]
["Phenobarbital","constitutive androstane receptor",0,0,0,0,"NR1I3","16153763",2005,"CAR expression and inducibility of CYP2B genes in liver of rats treated with PB-like inducers.","16153763","Phenobarbital","constitutive androstane receptor"]
["Phenobarbital","constitutive androstane receptor",0,0,0,0,"NR1I3","11343253",2001,"The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR.","11343253","Phenobarbital","constitutive androstane receptor"]
["Phenobarbital","constitutive androstane receptor",0,0,0,0,"NR1I3","12573483",2003,"Phenobarbital induction of drug/steroid-metabolizing enzymes and nuclear receptor CAR.","12573483","Phenobarbital","constitutive androstane receptor"]
["Phenobarbital","constitutive androstane receptor",0,0,0,1,"NR1I3","24464994",2014,"Computational modeling identifies key gene regulatory interactions underlying phenobarbital-mediated tumor promotion.","24464994","Phenobarbital","constitutive androstane receptor"]
["Phenobarbital","constitutive androstane receptor",0,0,0,0,"NR1I3","22815988",2012,"MicroRNA-122 down-regulation is involved in phenobarbital-mediated activation of the constitutive androstane receptor.","22815988","Phenobarbital","constitutive androstane receptor"]
["Phenobarbital","constitutive androstane receptor",0,0,0,0,"NR1I3","20955791",2011,"Transport of 5,5-diphenylbarbituric acid and its precursors and their effect on P-gp, MRP2 and CYP3A4 in Caco-2 and LS180 cells.","20955791","Phenobarbital","constitutive androstane receptor"]
["Phenobarbital","constitutive androstane receptor",0,0,0,0,"NR1I3","21455306",2011,"Phenobarbital mediates an epigenetic switch at the constitutive androstane receptor (CAR) target gene Cyp2b10 in the liver of B6C3F1 mice.","21455306","Phenobarbital","constitutive androstane receptor"]
["Phenobarbital","constitutive androstane receptor",0,0,0,0,"NR1I3","11752199",2002,"Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital.","11752199","Phenobarbital","constitutive androstane receptor"]
["Phenobarbital","constitutive androstane receptor",0,0,0,0,"NR1I3","15564320",2005,"Role of the constitutive androstane receptor in xenobiotic-induced thyroid hormone metabolism.","15564320","Phenobarbital","constitutive androstane receptor"]
["Phenobarbital","constitutive androstane receptor",0,0,0,0,"NR1I3","12885400",2003,"Identification of the nuclear receptor CAR:HSP90 complex in mouse liver and recruitment of protein phosphatase 2A in response to phenobarbital.","12885400","Phenobarbital","constitutive androstane receptor"]
["Phenobarbital","constitutive androstane receptor",0,0,0,0,"NR1I3","21912117",2011,"Antiepileptic drugs reduce the efficacy of methotrexate chemotherapy through accelerated degradation of the reduced folate carrier by the ubiquitin-proteasome pathway.","21912117","Phenobarbital","constitutive androstane receptor"]
["Phenobarbital","constitutive androstane receptor",0,0,0,0,"NR1I3","10454578",1999,"Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene.","10454578","Phenobarbital","constitutive androstane receptor"]
["Phenobarbital","constitutive androstane receptor",0,0,0,0,"NR1I3","23652203",2013,"Phenobarbital indirectly activates the constitutive active androstane receptor (CAR) by inhibition of epidermal growth factor receptor signaling.","23652203","Phenobarbital","constitutive androstane receptor"]
["Phenobarbital","constitutive androstane receptor",0,0,0,0,"NR1I3","20488228",2010,"Lack of P-glycoprotein induction by rifampicin and phenobarbital in human lymphocytes.","20488228","Phenobarbital","constitutive androstane receptor"]
["Phenobarbital","constitutive androstane receptor",0,0,0,0,"NR1I3","15572372",2005,"AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line.","15572372","Phenobarbital","constitutive androstane receptor"]
["Phenobarbital","constitutive androstane receptor",0,0,0,0,"NR1I3","19708687",2009,"Transcriptional activation of PPARalpha by phenobarbital in the absence of CAR and PXR.","19708687","Phenobarbital","constitutive androstane receptor"]
["Phenobarbital","constitutive androstane receptor",0,0,0,0,"NR1I3","12124310",2002,"Role of constitutive androstane receptor in the in vivo induction of Mrp3 and CYP2B1/2 by phenobarbital.","12124310","Phenobarbital","constitutive androstane receptor"]
["Phenobarbital","constitutive androstane receptor",0,0,0,0,"NR1I3","19433268",2009,"Decreased apoptosis during CAR-mediated hepatoprotection against lithocholic acid-induced liver injury in mice.","19433268","Phenobarbital","constitutive androstane receptor"]
["Phenobarbital","constitutive androstane receptor",0,0,0,0,"NR1I3","22382835",2012,"[Involvement of microRNA in the induction of drug-metabolizing enzymes].","22382835","Phenobarbital","constitutive androstane receptor"]
["Phenobarbital","constitutive androstane receptor",0,0,0,1,"NR1I3","20403969",2010,"Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo.","20403969","Phenobarbital","constitutive androstane receptor"]
["Phenobarbital","constitutive androstane receptor",0,0,0,1,"NR1I3","23291559",2013,"Nuclear receptor CAR specifically activates the two-pore K+ channel Kcnk1 gene in male mouse livers, which attenuates phenobarbital-induced hepatic hyperplasia.","23291559","Phenobarbital","constitutive androstane receptor"]
["Phenobarbital","constitutive androstane receptor",0,0,0,0,"NR1I3","11861787",2002,"Enhanced induction of cytochrome P450 enzymes and CAR binding in TNF (p55(-/-)/p75(-/-)) double receptor knockout mice following phenobarbital treatment.","11861787","Phenobarbital","constitutive androstane receptor"]
["Phenobarbital","constitutive androstane receptor",0,0,0,0,"NR1I3","16684649",2006,"Phenobarbital confers its diverse effects by activating the orphan nuclear receptor car.","16684649","Phenobarbital","constitutive androstane receptor"]
["Phenobarbital","constitutive androstane receptor",0,0,0,1,"NR1I3","17445763",2007,"Phenobarbital suppresses vitamin D3 25-hydroxylase expression: a potential new mechanism for drug-induced osteomalacia.","17445763","Phenobarbital","constitutive androstane receptor"]
["Phenobarbital","constitutive androstane receptor",0,0,0,1,"NR1I3","19286836",2009,"Regulation of human vitamin D(3) 25-hydroxylases in dermal fibroblasts and prostate cancer LNCaP cells.","19286836","Phenobarbital","constitutive androstane receptor"]
["Phenobarbital","constitutive androstane receptor",0,0,0,0,"NR1I3","16725103",2006,"Analysis of multiple nuclear receptor binding sites for CAR/RXR in the phenobarbital responsive unit of CYP2B2.","16725103","Phenobarbital","constitutive androstane receptor"]
["Phenobarbital","constitutive androstane receptor",0,0,0,0,"NR1I3","19920082",2010,"Dependence on the microtubule network and 90-kDa heat shock protein of phenobarbital-induced nuclear translocation of the rat constitutive androstane receptor.","19920082","Phenobarbital","constitutive androstane receptor"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L1476,L1476)","v":"Phenobarbital"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M1476,M1476)","v":"constitutive androstane receptor"},0,0,0,0,"NR1I3",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K1476,K1476)","v":"16799975"},2006,"Phenobarbital regulates nuclear expression of HNF-4alpha in mouse and rat hepatocytes independent of CAR and PXR.","16799975","Phenobarbital","constitutive androstane receptor"]
["Phenobarbital","constitutive androstane receptor",0,0,0,0,"NR1I3","19541828",2009,"Genetic polymorphisms in the TATA box and upstream phenobarbital-responsive enhancer module of the UGT1A1 promoter have combined effects on UDP-glucuronosyltransferase 1A1 transcription mediated by constitutive androstane receptor, pregnane X receptor, or glucocorticoid receptor in human liver.","19541828","Phenobarbital","constitutive androstane receptor"]
["Phenobarbital","constitutive androstane receptor",0,0,0,0,"NR1I3","17032173",2007,"A physiological role of AMP-activated protein kinase in phenobarbital-mediated constitutive androstane receptor activation and CYP2B induction.","17032173","Phenobarbital","constitutive androstane receptor"]
["Phenobarbital","constitutive androstane receptor",0,0,0,0,"NR1I3","16936065",2006,"Phenytoin induction of the cyp2c37 gene is mediated by the constitutive androstane receptor.","16936065","Phenobarbital","constitutive androstane receptor"]
["Phenobarbital","constitutive androstane receptor",0,0,0,0,"NR1I3","17341620",2006,"Effects of TK promotor and hepatocyte nuclear factor-4 in CAR-mediated transcriptional activity of phenobarbital responsive unit of CYP2B gene in monkey kidney epithelial-derived cell line COS-7.","17341620","Phenobarbital","constitutive androstane receptor"]
["Phenobarbital","constitutive androstane receptor",0,0,0,0,"NR1I3","10037683",1999,"The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene.","10037683","Phenobarbital","constitutive androstane receptor"]
["Phenobarbital","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","19920082",2010,"Dependence on the microtubule network and 90-kDa heat shock protein of phenobarbital-induced nuclear translocation of the rat constitutive androstane receptor.","19920082","Phenobarbital","Receptors, Glucocorticoid"]
["Phenobarbital","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","19541828",2009,"Genetic polymorphisms in the TATA box and upstream phenobarbital-responsive enhancer module of the UGT1A1 promoter have combined effects on UDP-glucuronosyltransferase 1A1 transcription mediated by constitutive androstane receptor, pregnane X receptor, or glucocorticoid receptor in human liver.","19541828","Phenobarbital","Receptors, Glucocorticoid"]
["Phenobarbital","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","1978678",1990,"Effect of phenobarbital on the glucocorticoid receptor in rat hepatoma cells.","1978678","Phenobarbital","Receptors, Glucocorticoid"]
["Phenobarbital","PPAR alpha",0,0,0,0,"PPARA","19631232",2009,"Synergistic acceleration of thyroid hormone degradation by phenobarbital and the PPAR alpha agonist WY14643 in rat hepatocytes.","19631232","Phenobarbital","PPAR alpha"]
["Phenobarbital","PPAR alpha",0,0,0,0,"PPARA","19541828",2009,"Genetic polymorphisms in the TATA box and upstream phenobarbital-responsive enhancer module of the UGT1A1 promoter have combined effects on UDP-glucuronosyltransferase 1A1 transcription mediated by constitutive androstane receptor, pregnane X receptor, or glucocorticoid receptor in human liver.","19541828","Phenobarbital","PPAR alpha"]
["Phenobarbital","PPAR alpha",0,0,0,0,"PPARA","19708687",2009,"Transcriptional activation of PPARalpha by phenobarbital in the absence of CAR and PXR.","19708687","Phenobarbital","PPAR alpha"]
["Phenytoin","pregnane X receptor",0,0,1,0,"NR1I2","15123723",2004,"Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin.","15123723","Phenytoin","pregnane X receptor"]
["Phenytoin","pregnane X receptor",0,0,1,0,"NR1I2","16936065",2006,"Phenytoin induction of the cyp2c37 gene is mediated by the constitutive androstane receptor.","16936065","Phenytoin","pregnane X receptor"]
["Phenytoin","constitutive androstane receptor",0,0,1,0,"NR1I3","16936065",2006,"Phenytoin induction of the cyp2c37 gene is mediated by the constitutive androstane receptor.","16936065","Phenytoin","constitutive androstane receptor"]
["Phenytoin","constitutive androstane receptor",0,0,1,0,"NR1I3","15123723",2004,"Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin.","15123723","Phenytoin","constitutive androstane receptor"]
["Phenytoin","constitutive androstane receptor",0,0,1,0,"NR1I3","15155833",2004,"The constitutive active/androstane receptor regulates phenytoin induction of Cyp2c29.","15155833","Phenytoin","constitutive androstane receptor"]
["Phenytoin","Receptors, Glucocorticoid",0,0,1,1,"NR3C1","2867743",1985,"Glucocorticoid receptor IB: mediator of anti-inflammatory and teratogenic functions of both glucocorticoids and phenytoin.","2867743","Phenytoin","Receptors, Glucocorticoid"]
["Phenytoin","Receptors, Glucocorticoid",0,0,1,1,"NR3C1","2519305",1989,"The relation between phenytoin-receptor and glucocorticoid in the induction of cleft palate with phenytoin in mice.","2519305","Phenytoin","Receptors, Glucocorticoid"]
["Phenytoin","Receptors, Glucocorticoid",0,0,1,1,"NR3C1","1687470",1991,"Restriction fragment length polymorphisms, glucocorticoid receptors, and phenytoin-induced cleft palate in congenic strains of mice with steroid susceptibility differences.","1687470","Phenytoin","Receptors, Glucocorticoid"]
["Phenytoin","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","1799368",1991,"Increased glucocorticoid receptors in diphenylhydantoin induced human gingival overgrowth.","1799368","Phenytoin","Receptors, Glucocorticoid"]
["Phenytoin","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","6439630",1984,"H-2 influences phenytoin binding and inhibition of prostaglandin synthesis.","6439630","Phenytoin","Receptors, Glucocorticoid"]
["Phenytoin","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","6634717",1983,"Inhibition of programmed cell death in mouse embryonic palate in vitro by cortisol and phenytoin: receptor involvement and requirement of protein synthesis.","6634717","Phenytoin","Receptors, Glucocorticoid"]
["Phenytoin","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","6897299",1982,"Diphenylhydantoin: an alternative ligand of a glucocorticoid receptor affecting prostaglandin generation in A/J mice.","6897299","Phenytoin","Receptors, Glucocorticoid"]
["Phenytoin","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","6389029",1984,"Biochemical mechanism of glucocorticoid-and phenytoin-induced cleft palate.","6389029","Phenytoin","Receptors, Glucocorticoid"]
["Piperonyl Butoxide","constitutive androstane receptor",1,0,1,1,"NR1I3","23531792",2013,"Different pathways of constitutive androstane receptor-mediated liver hypertrophy and hepatocarcinogenesis in mice treated with piperonyl butoxide or decabromodiphenyl ether.","23531792","Piperonyl Butoxide","constitutive androstane receptor"]
["Piperonyl Butoxide","PPAR alpha",1,0,1,1,"PPARA","20127075",2010,"Evaluation of in vivo liver genotoxic potential of Wy-14,643 and piperonyl butoxide in rats subjected to two-week repeated oral administration.","20127075","Piperonyl Butoxide","PPAR alpha"]
["Propanil","Receptors, Glucocorticoid",1,0,1,1,"NR3C1","15762548",2005,"Characterization of thymic atrophy and the mechanism of thymocyte depletion after in vivo exposure to a mixture of herbicides.","15762548","Propanil","Receptors, Glucocorticoid"]
["propiconazole","constitutive androstane receptor",0,0,1,1,"NR1I3","24675475",2014,"Phenobarbital and propiconazole toxicogenomic profiles in mice show major similarities consistent with the key role that constitutive androstane receptor (CAR) activation plays in their mode of action.","24675475","propiconazole","constitutive androstane receptor"]
["Quercetin","pregnane X receptor",0,0,1,0,"NR1I2","23162896",2012,"[Effects of isorhamnetin on CYP3A4 and herb-drug interaction].","23162896","Quercetin","pregnane X receptor"]
["Quercetin","constitutive androstane receptor",0,0,1,0,"NR1I3","21445586",2011,"Suppressive effect of enzymatically modified isoquercitrin on phenobarbital-induced liver tumor promotion in rats.","21445586","Quercetin","constitutive androstane receptor"]
["Quercetin","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","19423323",2010,"Suppressive effect of quercetin on acute stress-induced hypothalamic-pituitary-adrenal axis response in Wistar rats.","19423323","Quercetin","Receptors, Glucocorticoid"]
["Quercetin","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","10590836",1999,"Inhibition of heat shock factor activity prevents heat shock potentiation of glucocorticoid receptor-mediated gene expression.","10590836","Quercetin","Receptors, Glucocorticoid"]
["Quercetin","PPAR alpha",0,0,1,0,"PPARA","22183794",2012,"In vivo and in vitro protective effects of pentamethylquercetin on cardiac hypertrophy.","22183794","Quercetin","PPAR alpha"]
["Quercetin","PPAR alpha",0,0,1,0,"PPARA","24124108",2014,"Quercetin prevents liver carcinogenesis by inducing cell cycle arrest, decreasing cell proliferation and enhancing apoptosis.","24124108","Quercetin","PPAR alpha"]
["Quercetin","PPAR alpha",0,0,1,0,"PPARA","21462320",2011,"Chronic dietary intake of quercetin alleviates hepatic fat accumulation associated with consumption of a Western-style diet in C57/BL6J mice.","21462320","Quercetin","PPAR alpha"]
["Quercetin","PPAR alpha",0,0,1,0,"PPARA","22945467",2012,"Selected nutraceutic screening by therapeutic effects on doxorubicin-induced chronic kidney disease.","22945467","Quercetin","PPAR alpha"]
["Quercetin","PPAR gamma",0,0,1,0,"PPARG","17998018",2007,"Growth arrest and apoptosis induced by quercetin is not linked to adipogenic conversion of human preadipocytes.","17998018","Quercetin","PPAR gamma"]
["Quercetin","PPAR gamma",0,0,1,0,"PPARG","19928818",2010,"Dietary compound quercitrin dampens VEGF induction and PPARgamma activation in oxidized LDL-exposed murine macrophages: association with scavenger receptor CD36.","19928818","Quercetin","PPAR gamma"]
["Quercetin","PPAR gamma",0,0,1,0,"PPARG","24039778",2013,"Quercetin inhibits left ventricular hypertrophy in spontaneously hypertensive rats and inhibits angiotensin II-induced H9C2 cells hypertrophy by enhancing PPAR-? expression and suppressing AP-1 activity.","24039778","Quercetin","PPAR gamma"]
["Quercetin","PPAR gamma",0,0,1,0,"PPARG","20580672",2010,"Quercetin enhances adiponectin secretion by a PPAR-gamma independent mechanism.","20580672","Quercetin","PPAR gamma"]
["Quercetin","PPAR gamma",0,0,1,0,"PPARG","18433793",2008,"Enhanced inhibition of adipogenesis and induction of apoptosis in 3T3-L1 adipocytes with combinations of resveratrol and quercetin.","18433793","Quercetin","PPAR gamma"]
["Quercetin","PPAR gamma",0,0,1,0,"PPARG","23399664",2013,"Quercetin up-regulates expressions of peroxisome proliferator-activated receptor ?, liver X receptor ?, and ATP binding cassette transporter A1 genes and increases cholesterol efflux in human macrophage cell line.","23399664","Quercetin","PPAR gamma"]
["Quercetin","PPAR gamma",0,0,1,0,"PPARG","21267808",2011,"Plasma rich in quercetin metabolites induces G2/M arrest by upregulating PPAR-? expression in human A549 lung cancer cells.","21267808","Quercetin","PPAR gamma"]
["Quercetin","PPAR gamma",0,0,1,0,"PPARG","22992727",2012,"Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor ? activation pathway in gastric cancer.","22992727","Quercetin","PPAR gamma"]
["Quercetin","PPAR gamma",0,0,1,0,"PPARG","18262572",2008,"Kaempferol and quercetin isolated from Euonymus alatus improve glucose uptake of 3T3-L1 cells without adipogenesis activity.","18262572","Quercetin","PPAR gamma"]
["Quercetin","PPAR gamma",0,0,1,0,"PPARG","22870818",2012,"Rhamnetin-induced suppression of clonal expansion during early stage of adipogenesis.","22870818","Quercetin","PPAR gamma"]
["Quercetin","PPAR gamma",0,0,1,0,"PPARG","20943792",2010,"Quercetin is equally or more effective than resveratrol in attenuating tumor necrosis factor-{alpha}-mediated inflammation and insulin resistance in primary human adipocytes.","20943792","Quercetin","PPAR gamma"]
["Quercetin","PPAR gamma",0,0,1,0,"PPARG","21734632",2011,"Pentamethylquercetin improves adiponectin expression in differentiated 3T3-L1 cells via a mechanism that implicates PPAR? together with TNF-? and IL-6.","21734632","Quercetin","PPAR gamma"]
["Quercetin","PPAR gamma",0,0,1,0,"PPARG","19516153",2009,"Effects of quercetin and EGCG on mitochondrial biogenesis and immunity.","19516153","Quercetin","PPAR gamma"]
["Quercetin","PPAR gamma",0,0,1,0,"PPARG","15789741",2005,"Design and synthesis of novel antidiabetic agents.","15789741","Quercetin","PPAR gamma"]
["Quercetin","PPAR gamma",0,0,1,0,"PPARG","16777073",2006,"The flavonoid quercetin induces apoptosis and inhibits JNK activation in intimal vascular smooth muscle cells.","16777073","Quercetin","PPAR gamma"]
["Quercetin","PPAR gamma",0,0,1,0,"PPARG","17374653",2007,"Quercetin and isorhamnetin prevent endothelial dysfunction, superoxide production, and overexpression of p47phox induced by angiotensin II in rat aorta.","17374653","Quercetin","PPAR gamma"]
["Quercetin","PPAR gamma",0,0,1,0,"PPARG","20307882",2010,"Impact of apolipoprotein E genotype and dietary quercetin on paraoxonase 1 status in apoE3 and apoE4 transgenic mice.","20307882","Quercetin","PPAR gamma"]
["Quercetin","PPAR gamma",0,0,1,0,"PPARG","21833991",2012,"Influence of quercetin-rich onion peel extracts on adipokine expression in the visceral adipose tissue of rats.","21833991","Quercetin","PPAR gamma"]
["Quercetin","PPAR gamma",0,0,1,0,"PPARG","21833993",2012,"Suppressive effects of quercetin-3-O-(6?-Feruloyl)-?-D-galactopyranoside on adipogenesis in 3T3-L1 preadipocytes through down-regulation of PPAR? and C/EBP? expression.","21833993","Quercetin","PPAR gamma"]
["Sodium Fluoride","Receptors, Glucocorticoid",1,0,0,0,"NR3C1","6492796",1984,"Influence of phosphatase inhibitors and nucleotides on [3H]dexamethasone binding in cytosol of human placenta.","6492796","Sodium Fluoride","Receptors, Glucocorticoid"]
["Spironolactone","pregnane X receptor",0,0,1,0,"NR1I2","24101390",2013,"A study comparing the efficacy of antimicrobial agents versus enzyme (P-gp) inducers in the treatment of 2,4,6 trinitrobenzenesulfonic acid-induced colitis in rats.","24101390","Spironolactone","pregnane X receptor"]
["Spironolactone","pregnane X receptor",0,0,1,0,"NR1I2","19766108",2009,"Induction of intestinal multidrug resistance-associated protein 2 (Mrp2) by spironolactone in rats.","19766108","Spironolactone","pregnane X receptor"]
["Spironolactone","pregnane X receptor",0,0,1,0,"NR1I2","21459122",2011,"Pregnane X receptor mediates the induction of P-glycoprotein by spironolactone in HepG2 cells.","21459122","Spironolactone","pregnane X receptor"]
["Spironolactone","pregnane X receptor",0,0,1,0,"NR1I2","9855641",1998,"Environmental xenobiotics and the antihormones cyproterone acetate and spironolactone use the nuclear hormone pregnenolone X receptor to activate the CYP3A23 hormone response element.","9855641","Spironolactone","pregnane X receptor"]
["Spironolactone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","23044404",2013,"Mineralocorticoid receptor antagonist spironolactone prevents chronic corticosterone induced depression-like behavior.","23044404","Spironolactone","Receptors, Glucocorticoid"]
["Spironolactone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","23544271",2013,"Glucocorticoid-induced hypertension and cardiac injury: effects of mineralocorticoid and glucocorticoid receptor antagonism.","23544271","Spironolactone","Receptors, Glucocorticoid"]
["Spironolactone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","6097705",1984,"[Pharmacological mechanism of modern diuretics. Aldosterone antagonists].","6097705","Spironolactone","Receptors, Glucocorticoid"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L1540,L1540)","v":"Spironolactone"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M1540,M1540)","v":"Receptors, Glucocorticoid"},0,0,1,0,"NR3C1",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K1540,K1540)","v":"1532165"},1992,"Aldosterone reduces baroreceptor discharge in the dog.","1532165","Spironolactone","Receptors, Glucocorticoid"]
["Spironolactone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2453182",1987,"Binding of natural spirolactone derivatives to mineralo- and glucocorticoid receptors of the rat kidney.","2453182","Spironolactone","Receptors, Glucocorticoid"]
["Spironolactone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2843562",1988,"Adrenocorticotropin and cortisol-induced changes in urinary sodium and potassium excretion in man: effects of spironolactone and RU486.","2843562","Spironolactone","Receptors, Glucocorticoid"]
["Spironolactone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","15134814",2004,"Towards selectively modulating mineralocorticoid receptor function: lessons from other systems.","15134814","Spironolactone","Receptors, Glucocorticoid"]
["Spironolactone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","1986923",1991,"Autoradiographic evidence of nuclear binding of spironolactone in rabbit cortical collecting tubule.","1986923","Spironolactone","Receptors, Glucocorticoid"]
["Spironolactone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","23303058",2013,"Blocking mineralocorticoid receptors impairs, blocking glucocorticoid receptors enhances memory retrieval in humans.","23303058","Spironolactone","Receptors, Glucocorticoid"]
["Spironolactone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2550833",1989,"On the role of brain mineralocorticoid (type I) and glucocorticoid (type II) receptors in neuroendocrine regulation.","2550833","Spironolactone","Receptors, Glucocorticoid"]
["Spironolactone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","436757",1979,"Mechanism of action of a new antialdosterone compound, prorenone.","436757","Spironolactone","Receptors, Glucocorticoid"]
["Spironolactone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","14664717",2003,"Determinants of spironolactone binding specificity in the mineralocorticoid receptor.","14664717","Spironolactone","Receptors, Glucocorticoid"]
["Spironolactone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","12657604",2003,"Serum- and glucocorticoid-regulated kinase isoform-1 and epithelial sodium channel subunits in human ocular ciliary epithelium.","12657604","Spironolactone","Receptors, Glucocorticoid"]
["Spironolactone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","20962442",2010,"Resistant hypertension in an aged woman presenting with clinical features simulating ectopic ACTH syndrome--response to spironolactone--.","20962442","Spironolactone","Receptors, Glucocorticoid"]
["Spironolactone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","15554912",2004,"Differences in the determinants of eplerenone, spironolactone and aldosterone binding to the mineralocorticoid receptor.","15554912","Spironolactone","Receptors, Glucocorticoid"]
["Spironolactone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","19799583",2010,"Mifepristone and spironolactone differently alter cocaine intravenous self-administration and cocaine-induced locomotion in C57BL/6J mice.","19799583","Spironolactone","Receptors, Glucocorticoid"]
["Spironolactone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","11012846",2000,"Selective blockade of the mineralocorticoid receptor impairs hypothalamic-pituitary-adrenal axis expression of habituation.","11012846","Spironolactone","Receptors, Glucocorticoid"]
["Spironolactone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2825817",1988,"Paradoxical differences in the receptor binding of two new antimineralocorticoids.","2825817","Spironolactone","Receptors, Glucocorticoid"]
["Spironolactone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","15671079",2005,"Disruption of mineralocorticoid receptor function increases corticosterone responding to a mild, but not moderate, psychological stressor.","15671079","Spironolactone","Receptors, Glucocorticoid"]
["Spironolactone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","11698067",2001,"Intracerebroventricular administration of a glucocorticoid receptor antagonist enhances the cardiovascular responses to brief restraint stress.","11698067","Spironolactone","Receptors, Glucocorticoid"]
["Spironolactone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3193846",1988,"ZK91587: a novel synthetic antimineralocorticoid displays high affinity for corticosterone (type I) receptors in the rat hippocampus.","3193846","Spironolactone","Receptors, Glucocorticoid"]
["Spironolactone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","1309341",1992,"Spironolactone, an aldosterone antagonist, acts as an antiglucocorticosteroid on the mouse mammary tumor virus promoter.","1309341","Spironolactone","Receptors, Glucocorticoid"]
["Spironolactone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","15631890",2005,"Blockage of glucocorticoid, but not mineralocorticoid receptors prevents the persistent increase in circulating basal corticosterone concentrations following stress in the rat.","15631890","Spironolactone","Receptors, Glucocorticoid"]
["Spironolactone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2977239",1988,"Synthesis of new fluorescent spirolactone derivatives: determination of their affinities for aldosterone receptors.","2977239","Spironolactone","Receptors, Glucocorticoid"]
["Spironolactone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","1913190",1991,"Potentiation of angiotensin II-induced drinking by glucocorticoids is a specific glucocorticoid type II receptor (GR)-mediated event.","1913190","Spironolactone","Receptors, Glucocorticoid"]
["Spironolactone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2949071",1987,"Three new epoxy-spirolactone derivatives: characterization in vivo and in vitro.","2949071","Spironolactone","Receptors, Glucocorticoid"]
["Spironolactone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","21515309",2011,"Antidepressant-like effects of mineralocorticoid but not glucocorticoid antagonists in the lateral septum: interactions with the serotonergic system.","21515309","Spironolactone","Receptors, Glucocorticoid"]
["Spironolactone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3720022",1986,"Adrenocorticoid-dependent alpha-lactalbumin synthesis in rat mammary gland explants: antagonist studies.","3720022","Spironolactone","Receptors, Glucocorticoid"]
["Spironolactone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","19141586",2009,"Combined receptor antagonist stimulation of the hypothalamic-pituitary-adrenal axis test identifies impaired negative feedback sensitivity to cortisol in obese men.","19141586","Spironolactone","Receptors, Glucocorticoid"]
["Spironolactone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","15591147",2005,"Glucocorticoid receptor blockade disinhibits pituitary-adrenal activity during the stress hyporesponsive period of the mouse.","15591147","Spironolactone","Receptors, Glucocorticoid"]
["Spironolactone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","6217754",1983,"Binding and antimineralocorticoid activities of spirolactones in toad bladder.","6217754","Spironolactone","Receptors, Glucocorticoid"]
["Spironolactone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8295159",1993,"Functional properties of deoxycorticosterone and spironolactone: molecular characterization and effects on sleep-endocrine activity.","8295159","Spironolactone","Receptors, Glucocorticoid"]
["Spironolactone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","6128090",1982,"Spironolactone: a glucocorticoid agonist or antagonist?","6128090","Spironolactone","Receptors, Glucocorticoid"]
["Spironolactone","Receptors, Glucocorticoid",0,0,1,1,"NR3C1","6456707",1981,"[Intolerance to spironolactone in refractory cardiac insufficiency. Probable changes in the aldosterone receptors. Study of 11 cases].","6456707","Spironolactone","Receptors, Glucocorticoid"]
["Spironolactone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8532822",1995,"Anxiolytic-like effects of selective mineralocorticoid and glucocorticoid antagonists on fear-enhanced behavior in the elevated plus-maze.","8532822","Spironolactone","Receptors, Glucocorticoid"]
["Spironolactone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","7825904",1994,"The effects of RU 38486 and RU 28318 on energy balance of ovariectomized rats.","7825904","Spironolactone","Receptors, Glucocorticoid"]
["Spironolactone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8360885",1993,"Synthesis of new 11 beta-substituted spirolactone derivatives. Relationship with affinity for mineralocorticoid and glucocorticoid receptors.","8360885","Spironolactone","Receptors, Glucocorticoid"]
["Spironolactone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","996562",1976,"[Clinical pharmacology. Pharmacokinetics and affinity of drugs for their receptors, Apropos of anti-aldosterone].","996562","Spironolactone","Receptors, Glucocorticoid"]
["Spironolactone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","9879980",1998,"Evaluation of RU28318 and RU40555 as selective mineralocorticoid receptor and glucocorticoid receptor antagonists, respectively: receptor measures and functional studies.","9879980","Spironolactone","Receptors, Glucocorticoid"]
["Spironolactone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8528892",1994,"Type I glucocorticoid receptor blockade does not affect baseline or ovine corticotropin-releasing-hormone-stimulated adrenocorticotropic hormone and cortisol secretion.","8528892","Spironolactone","Receptors, Glucocorticoid"]
["Spironolactone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","9077590",1997,"Hippocampal mineralocorticoid, but not glucocorticoid, receptors modulate anxiety-like behavior in rats.","9077590","Spironolactone","Receptors, Glucocorticoid"]
["Spironolactone","PPAR gamma",0,0,1,0,"PPARG","17998773",2007,"Combination therapy with telmisartan and spironolactone alleviates L-NAME exacerbated nephrosclerosis with an increase in PPAR-gamma and decrease in TGF-beta(1).","17998773","Spironolactone","PPAR gamma"]
["Spironolactone","PPAR gamma",0,0,1,0,"PPARG","21451213",2011,"Effect of eplerenone on hypertension-associated renal damage in rats: potential role of peroxisome proliferator activated receptor gamma (PPAR-?).","21451213","Spironolactone","PPAR gamma"]
["Sulfasalazine","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","17267514",2007,"Sulfasalazine sensitises human monocytic/macrophage cells for glucocorticoids by upregulation of glucocorticoid receptor alpha and glucocorticoid induced apoptosis.","17267514","Sulfasalazine","Receptors, Glucocorticoid"]
["Sulfasalazine","PPAR gamma",1,0,1,0,"PPARG","24145089",2013,"Comparative evaluation of different doses of PPAR-? agonist alone and in combination with sulfasalazine in experimentally induced inflammatory bowel disease in rats.","24145089","Sulfasalazine","PPAR gamma"]
["Sulfasalazine","PPAR gamma",1,0,1,0,"PPARG","19365232",2009,"Genomic analysis of sulfasalazine effect in experimental colitis is consistent primarily with the modulation of NF-kappaB but not PPAR-gamma signaling.","19365232","Sulfasalazine","PPAR gamma"]
["Tamoxifen","pregnane X receptor",0,0,1,0,"NR1I2","17526937",2006,"Tamoxifen activates CYP3A4 and MDR1 genes through steroid and xenobiotic receptor in breast cancer cells.","17526937","Tamoxifen","pregnane X receptor"]
["Tamoxifen","pregnane X receptor",0,0,1,0,"NR1I2","18299335",2008,"Role of human pregnane X receptor in tamoxifen- and 4-hydroxytamoxifen-mediated CYP3A4 induction in primary human hepatocytes and LS174T cells.","18299335","Tamoxifen","pregnane X receptor"]
["Tamoxifen","pregnane X receptor",0,0,1,0,"NR1I2","11950795",2002,"Induction of cytochrome P450 3A4 in primary human hepatocytes and activation of the human pregnane X receptor by tamoxifen and 4-hydroxytamoxifen.","11950795","Tamoxifen","pregnane X receptor"]
["Tamoxifen","pregnane X receptor",0,0,1,0,"NR1I2","17639045",2007,"Induction of multidrug resistance associated protein 2 in tamoxifen-resistant breast cancer cells.","17639045","Tamoxifen","pregnane X receptor"]
["Tamoxifen","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","4007026",1985,"Tamoxifen alone or in combination with estradiol-17 beta inhibits the growth and malignant transformation of hepatic hyperplastic nodules.","4007026","Tamoxifen","Receptors, Glucocorticoid"]
["Tamoxifen","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","11999805",2001,"Effect of tamoxifen treatment at adolescent age on the sexual behaviour and steroid hormone receptor binding of adult female rats.","11999805","Tamoxifen","Receptors, Glucocorticoid"]
["Tamoxifen","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","2760029",1989,"The interaction site for tamoxifen aziridine with the bovine estrogen receptor.","2760029","Tamoxifen","Receptors, Glucocorticoid"]
["Tamoxifen","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","11821147",2002,"Tamoxifen protects clonal mouse hippocampal (HT-22) cells against neurotoxins-induced cell death.","11821147","Tamoxifen","Receptors, Glucocorticoid"]
["Tamoxifen","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","11065175",2000,"Effect of neonatal treatment with mifepristone or tamoxifen on the binding capacity of the thymic glucocorticoid or uterine estrogen receptor of adult rats: data on the mechanism of hormonal imprinting.","11065175","Tamoxifen","Receptors, Glucocorticoid"]
["Tamoxifen","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","18299335",2008,"Role of human pregnane X receptor in tamoxifen- and 4-hydroxytamoxifen-mediated CYP3A4 induction in primary human hepatocytes and LS174T cells.","18299335","Tamoxifen","Receptors, Glucocorticoid"]
["Tamoxifen","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","12438246",2002,"An estrogen-responsive element-targeted histone deacetylase enzyme has an antiestrogen activity that differs from that of hydroxytamoxifen.","12438246","Tamoxifen","Receptors, Glucocorticoid"]
["Tamoxifen","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","4007011",1985,"Tamoxifen alone or in combination with estradiol-17 beta inhibits the growth and malignant transformation of hepatic hyperplastic nodules.","4007011","Tamoxifen","Receptors, Glucocorticoid"]
["Tamoxifen","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","23805908",2013,"Tamoxifen inhibits macrophage FABP4 expression through the combined effects of the GR and PPAR? pathways.","23805908","Tamoxifen","Receptors, Glucocorticoid"]
["Tamoxifen","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","6840677",1983,"Evidence for the hormone dependency of hepatic hyperplastic nodules: inhibition of malignant transformation after exogenous 17 beta-estradiol and tamoxifen.","6840677","Tamoxifen","Receptors, Glucocorticoid"]
["Tamoxifen","PPAR alpha",0,0,1,1,"PPARA","17630414",2007,"Subchronic toxicity and toxicogenomic evaluation of tamoxifen citrate + bexarotene in female rats.","17630414","Tamoxifen","PPAR alpha"]
["Tamoxifen","PPAR gamma",0,0,1,0,"PPARG","21769696",2011,"The effects of Tamoxifen and fish oil on mammary carcinogenesis in polyoma middle T transgenic mice.","21769696","Tamoxifen","PPAR gamma"]
["Tamoxifen","PPAR gamma",0,0,1,0,"PPARG","22493352",2012,"CK20 expression enhances the invasiveness of tamoxifen-resistant MCF-7 cells.","22493352","Tamoxifen","PPAR gamma"]
["Tamoxifen","PPAR gamma",0,0,1,0,"PPARG","18835379",2008,"Troglitazone enhances tamoxifen-induced growth inhibitory activity of MCF-7 cells.","18835379","Tamoxifen","PPAR gamma"]
["Tamoxifen","PPAR gamma",0,0,1,0,"PPARG","23805908",2013,"Tamoxifen inhibits macrophage FABP4 expression through the combined effects of the GR and PPAR? pathways.","23805908","Tamoxifen","PPAR gamma"]
["Tamoxifen","PPAR gamma",0,0,1,0,"PPARG","22422660",2012,"Furanodiene enhances tamoxifen-induced growth inhibitory activity of ERa-positive breast cancer cells in a PPAR? independent manner.","22422660","Tamoxifen","PPAR gamma"]
["Tamoxifen","retinoic acid receptor alpha",0,0,1,0,"RARA","21299862",2011,"During hormone depletion or tamoxifen treatment of breast cancer cells the estrogen receptor apoprotein supports cell cycling through the retinoic acid receptor ?1 apoprotein.","21299862","Tamoxifen","retinoic acid receptor alpha"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L1604,L1604)","v":"Tamoxifen"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M1604,M1604)","v":"retinoic acid receptor alpha"},0,0,1,0,"RARA",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K1604,K1604)","v":"10076999"},1999,"Estrogen receptor beta activates the human retinoic acid receptor alpha-1 promoter in response to tamoxifen and other estrogen receptor antagonists, but not in response to estrogen.","10076999","Tamoxifen","retinoic acid receptor alpha"]
["Tannins","pregnane X receptor",0,0,0,0,"NR1I2","21704145",2011,"Pharmacological evaluation of insulin mimetic novel suppressors of PEPCK gene transcription from Paeoniae Rubra Radix.","21704145","Tannins","pregnane X receptor"]
["Tannins","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","21704145",2011,"Pharmacological evaluation of insulin mimetic novel suppressors of PEPCK gene transcription from Paeoniae Rubra Radix.","21704145","Tannins","Receptors, Glucocorticoid"]
["Tannins","PPAR alpha",0,0,0,0,"PPARA","23001493",2014,"Hypotriglyceridemic effects of apple polyphenols extract via up-regulation of lipoprotein lipase in triton WR-1339-induced mice.","23001493","Tannins","PPAR alpha"]
["Tannins","PPAR alpha",0,0,0,0,"PPARA","21736774",2011,"Tannic acid is more effective than clofibrate for the elevation of hepatic ?-oxidation and the inhibition of 3-hydroxy-3-methyl-glutaryl-CoA reductase and aortic lesion formation in apo E-deficient mice.","21736774","Tannins","PPAR alpha"]
["Tannins","PPAR gamma",0,0,0,0,"PPARG","24046866",2013,"Inhibitory effects of tannic acid on fatty acid synthase and 3T3-L1 preadipocyte.","24046866","Tannins","PPAR gamma"]
["Tannins","PPAR gamma",0,0,0,0,"PPARG","24334103",2014,"Phlorotannins isolated from the edible brown alga Ecklonia stolonifera exert anti-adipogenic activity on 3T3-L1 adipocytes by downregulating C/EBP? and PPAR?.","24334103","Tannins","PPAR gamma"]
["tebuconazole","constitutive androstane receptor",0,0,1,1,"NR1I3","23721867",2013,"Dose-response involvement of constitutive androstane receptor in mouse liver hypertrophy induced by triazole fungicides.","23721867","tebuconazole","constitutive androstane receptor"]
["tebufenozide","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","10417731",1999,"Ecdysone agonist inducible transcription in transgenic tobacco plants.","10417731","tebufenozide","Receptors, Glucocorticoid"]
["tetrabromobisphenol A","PPAR alpha",0,0,1,0,"PPARA","21561829",2011,"Peroxisome proliferator-activated receptor ? is a target for halogenated analogs of bisphenol A.","21561829","tetrabromobisphenol A","PPAR alpha"]
["tetrabromobisphenol A","PPAR alpha",0,0,1,0,"PPARA","21885366",2011,"Warm reception? Halogenated BPA flame retardants and PPAR? activation.","21885366","tetrabromobisphenol A","PPAR alpha"]
["tetrabromobisphenol A","PPAR gamma",0,0,1,0,"PPARG","23603401",2013,"Towards a humanized PPAR? reporter system for in vivo screening of obesogens.","23603401","tetrabromobisphenol A","PPAR gamma"]
["tetrabromobisphenol A","PPAR gamma",0,0,1,0,"PPARG","21561829",2011,"Peroxisome proliferator-activated receptor ? is a target for halogenated analogs of bisphenol A.","21561829","tetrabromobisphenol A","PPAR gamma"]
["tetrabromobisphenol A","PPAR gamma",0,0,1,1,"PPARG","24132472",2014,"PPAR-? agonist GW1929 but not antagonist GW9662 reduces TBBPA-induced neurotoxicity in primary neocortical cells.","24132472","tetrabromobisphenol A","PPAR gamma"]
["Theophylline","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","18391482",2008,"Anti-inflammatory effect of theophylline in rats and its involvement of the glucocorticoid-glucocorticoid receptor system.","18391482","Theophylline","Receptors, Glucocorticoid"]
["Theophylline","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","435564",1979,"[Activation of glucocorticoid cytoreceptors in rat heart].","435564","Theophylline","Receptors, Glucocorticoid"]
["Theophylline","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","10452840",1998,"A study of the effect of theophylline on the anti-inflammatory potency of dexamethasone using alpha-aminoisobutyric acid uptake in rat skin fibroblasts: a possible mechanism through the glucocorticoid receptor.","10452840","Theophylline","Receptors, Glucocorticoid"]
["Theophylline","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","7449749",1980,"Effect of theophylline on binding of cortisol to cytosolic receptors of human leukocytes.","7449749","Theophylline","Receptors, Glucocorticoid"]
["Theophylline","PPAR gamma",0,0,1,0,"PPARG","16569937",2006,"Theophylline and dexamethasone induce peroxisome proliferator-activated receptor-gamma expression in human eosinophils.","16569937","Theophylline","PPAR gamma"]
["Thiophanate","PPAR alpha",0,0,1,1,"PPARA","17329170",2007,"PPARalpha mediates the effects of the pesticide methyl thiophanate on liver of the lizard Podarcis sicula.","17329170","Thiophanate","PPAR alpha"]
["Thiram","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","16857225",2006,"Reduction of glucocorticoid receptor ligand binding by the 11-beta hydroxysteroid dehydrogenase type 2 inhibitor, Thiram.","16857225","Thiram","Receptors, Glucocorticoid"]
["tolyfluanid","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","15755314",2005,"Xenobiotics and the glucocorticoid receptor: additive antagonistic effects on tyrosine aminotransferase activity in rat hepatoma cells.","15755314","tolyfluanid","Receptors, Glucocorticoid"]
["tolyfluanid","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","23340252",2013,"The endocrine disrupting chemical tolylfluanid alters adipocyte metabolism via glucocorticoid receptor activation.","23340252","tolyfluanid","Receptors, Glucocorticoid"]
["Tretinoin","farnesoid X-activated receptor",1,0,1,1,"NR1H4","20338915",2010,"Retinoic acid represses CYP7A1 expression in human hepatocytes and HepG2 cells by FXR/RXR-dependent and independent mechanisms.","20338915","Tretinoin","farnesoid X-activated receptor"]
["Tretinoin","farnesoid X-activated receptor",1,0,1,0,"NR1H4","19111018",2009,"Low retinol levels differentially modulate bile salt-induced expression of human and mouse hepatic bile salt transporters.","19111018","Tretinoin","farnesoid X-activated receptor"]
["Tretinoin","pregnane X receptor",1,0,1,0,"NR1I2","12870655",2003,"Transcript profiling of cytochrome P450 genes in HL-60 human leukemic cells: upregulation of CYP1B1 by all-trans-retinoic acid.","12870655","Tretinoin","pregnane X receptor"]
["Tretinoin","pregnane X receptor",1,0,1,0,"NR1I2","17962516",2008,"Role of pregnane X receptor in control of all-trans retinoic acid (ATRA) metabolism and its potential contribution to ATRA resistance.","17962516","Tretinoin","pregnane X receptor"]
["Tretinoin","constitutive androstane receptor",1,0,1,0,"NR1I3","12870655",2003,"Transcript profiling of cytochrome P450 genes in HL-60 human leukemic cells: upregulation of CYP1B1 by all-trans-retinoic acid.","12870655","Tretinoin","constitutive androstane receptor"]
["Tretinoin","constitutive androstane receptor",1,0,1,0,"NR1I3","19686701",2010,"Retinoids activate RXR/CAR-mediated pathway and induce CYP3A.","19686701","Tretinoin","constitutive androstane receptor"]
["Tretinoin","constitutive androstane receptor",1,0,1,0,"NR1I3","11792692",2002,"Retinoic acids repress constitutive active receptor-mediated induction by 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene of the CYP2B10 gene in mouse primary hepatocytes.","11792692","Tretinoin","constitutive androstane receptor"]
["Tretinoin","constitutive androstane receptor",1,0,1,0,"NR1I3","11027641",2000,"Suppression of the expression of the CYP2B1/2 gene by retinoic acids.","11027641","Tretinoin","constitutive androstane receptor"]
["Tretinoin","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","2459262",1988,"Down-regulation of glucocorticoid binding sites by retinoic acid in squamous carcinoma cells resistant to the induction of keratinization by hydrocortisone.","2459262","Tretinoin","Receptors, Glucocorticoid"]
["Tretinoin","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","12487626",2003,"Cross-talk between glucocorticoid and retinoic acid signals involving glucocorticoid receptor interaction with the homoeodomain protein Pbx1.","12487626","Tretinoin","Receptors, Glucocorticoid"]
["Tretinoin","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","10959555",2000,"Regulation of LFA-3 (CD58) by dexamethasone and retinoic acids in vitro.","10959555","Tretinoin","Receptors, Glucocorticoid"]
["Tretinoin","Receptors, Glucocorticoid",1,0,1,1,"NR3C1","24346134",2013,"All-trans retinoic acid-induced hypothalamus-pituitary-adrenal hyperactivity involves glucocorticoid receptor dysregulation.","24346134","Tretinoin","Receptors, Glucocorticoid"]
["Tretinoin","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","2746001",1989,"Antagonistic effects of retinoic acid and hydrocortisone on terminal differentiation of human squamous carcinoma cells.","2746001","Tretinoin","Receptors, Glucocorticoid"]
["Tretinoin","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","11299304",2001,"Up-regulation of cyclooxygenase-1 in neuroblastoma cell lines by retinoic acid and corticosteroids.","11299304","Tretinoin","Receptors, Glucocorticoid"]
["Tretinoin","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","23398290",2013,"Retinoids and glucocorticoids target common genes in hippocampal HT22 cells.","23398290","Tretinoin","Receptors, Glucocorticoid"]
["Tretinoin","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","11585812",2001,"A glucocorticoid/retinoic acid receptor chimera that displays cytoplasmic/nuclear translocation in response to retinoic acid. A real time sensing assay for nuclear receptor ligands.","11585812","Tretinoin","Receptors, Glucocorticoid"]
["Tretinoin","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","10629053",2000,"Orphan receptor COUP-TF is required for induction of retinoic acid receptor beta, growth inhibition, and apoptosis by retinoic acid in cancer cells.","10629053","Tretinoin","Receptors, Glucocorticoid"]
["Tretinoin","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","19179438",2009,"Retinoic acid reduces glucocorticoid sensitivity in C2C12 myotubes by decreasing 11beta-hydroxysteroid dehydrogenase type 1 and glucocorticoid receptor activities.","19179438","Tretinoin","Receptors, Glucocorticoid"]
["Tretinoin","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","1350056",1992,"Inhibition of tyrosine aminotransferase gene expression by retinoic acid.","1350056","Tretinoin","Receptors, Glucocorticoid"]
["Tretinoin","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","1369275",1990,"Structure and function of the nuclear receptor superfamily for steroid, thyroid hormone and retinoic acid.","1369275","Tretinoin","Receptors, Glucocorticoid"]
["Tretinoin","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","1356818",1992,"Regulation of transglutaminase 1 gene expression by 12-O-tetradecanoylphorbol-13-acetate, dexamethasone, and retinoic acid in cultured human keratinocytes.","1356818","Tretinoin","Receptors, Glucocorticoid"]
["Tretinoin","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","8703946",1996,"Coordinate regulation of glucocorticoid receptor and c-jun gene expression is cell type-specific and exhibits differential hormonal sensitivity for down- and up-regulation.","8703946","Tretinoin","Receptors, Glucocorticoid"]
["Tretinoin","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","8804707",1996,"All-trans retinoic acid affects the expression of orphan receptors COUP-TF I and COUP-TF II in the developing neural tube.","8804707","Tretinoin","Receptors, Glucocorticoid"]
["Tretinoin","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","8382933",1993,"Effects of retinoic acid on steroid and vitamin D3 receptors in cultured mouse osteosarcoma cells.","8382933","Tretinoin","Receptors, Glucocorticoid"]
["Tretinoin","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","9773973",1998,"Structural requirements of the glucocorticoid and retinoic acid response units in the phosphoenolpyruvate carboxykinase gene promoter.","9773973","Tretinoin","Receptors, Glucocorticoid"]
["Tretinoin","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","7669692",1995,"COUP-TFI is a potential regulator of retinoic acid-modulated development in Xenopus embryos.","7669692","Tretinoin","Receptors, Glucocorticoid"]
["Tretinoin","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","7674376",1995,"Orphan receptor COUP-TF I antagonizes retinoic acid-induced neuronal differentiation.","7674376","Tretinoin","Receptors, Glucocorticoid"]
["Tretinoin","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","9006910",1997,"Identification of a retinoid/chicken ovalbumin upstream promoter transcription factor response element in the human retinoid X receptor gamma2 gene promoter.","9006910","Tretinoin","Receptors, Glucocorticoid"]
["Tretinoin","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","9449205",1997,"Correlation between the effects of retinoic acid and dexamethasone on liver tyrosine aminotransferase.","9449205","Tretinoin","Receptors, Glucocorticoid"]
["Tretinoin","Receptors, Glucocorticoid",1,0,1,1,"NR3C1","9130711",1997,"Modulation of retinoic acid sensitivity in lung cancer cells through dynamic balance of orphan receptors nur77 and COUP-TF and their heterodimerization.","9130711","Tretinoin","Receptors, Glucocorticoid"]
["Tretinoin","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","7575611",1995,"Antagonism of COUP-TF and PPAR alpha/RXR alpha on the activation of the malic enzyme gene promoter: modulation by 9-cis RA.","7575611","Tretinoin","Receptors, Glucocorticoid"]
["Tretinoin","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","9821019",1998,"Effect of retinoid (vitamin A or retinoic acid) treatment (hormonal imprinting) through breastmilk on the glucocorticoid receptor and estrogen receptor binding capacity of the adult rat offspring.","9821019","Tretinoin","Receptors, Glucocorticoid"]
["Tretinoin","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","9831119",1998,"All-trans-retinoic acid upregulates the expression of COUP-TFI in early-somite mouse embryos cultured in vitro.","9831119","Tretinoin","Receptors, Glucocorticoid"]
["Tretinoin","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","7994082",1994,"Effects of retinoic acid and dexamethasone on proliferation, differentiation, and glucocorticoid receptor expression in cultured human osteosarcoma cells.","7994082","Tretinoin","Receptors, Glucocorticoid"]
["Tretinoin","Nuclear Receptor Subfamily 4, Group A, Member 2",1,0,1,0,"NR4A2","22069189",2011,"Retinoic acid-dependent and -independent gene-regulatory pathways of Pitx3 in meso-diencephalic dopaminergic neurons.","22069189","Tretinoin","Nuclear Receptor Subfamily 4, Group A, Member 2"]
["Tretinoin","Nuclear Receptor Subfamily 4, Group A, Member 2",1,0,1,0,"NR4A2","16408307",2006,"Influence of retinoic acid and lithium on proliferation and dopaminergic potential of human NT2 cells.","16408307","Tretinoin","Nuclear Receptor Subfamily 4, Group A, Member 2"]
["Tretinoin","Nuclear Receptor Subfamily 4, Group A, Member 2",1,0,1,0,"NR4A2","19861119",2009,"NR4A orphan nuclear receptors influence retinoic acid and docosahexaenoic acid signaling via up-regulation of fatty acid binding protein 5.","19861119","Tretinoin","Nuclear Receptor Subfamily 4, Group A, Member 2"]
["Tretinoin","Nuclear Receptor Subfamily 4, Group A, Member 2",1,0,1,0,"NR4A2","20195526",2010,"Roles of db-cAMP, IBMX and RA in aspects of neural differentiation of cord blood derived mesenchymal-like stem cells.","20195526","Tretinoin","Nuclear Receptor Subfamily 4, Group A, Member 2"]
["Tretinoin","Nuclear Receptor Subfamily 4, Group A, Member 2",1,0,1,0,"NR4A2","22330803",2012,"Human cord blood-derived multipotent stem cells (CB-SCs) treated with all-trans-retinoic acid (ATRA) give rise to dopamine neurons.","22330803","Tretinoin","Nuclear Receptor Subfamily 4, Group A, Member 2"]
["Tretinoin","Nuclear Receptor Subfamily 4, Group A, Member 2",1,0,1,0,"NR4A2","9070291",1997,"Retinoic acids differentially regulate NOR-1 and its closely related orphan nuclear receptor genes in breast cancer cell line MCF-7.","9070291","Tretinoin","Nuclear Receptor Subfamily 4, Group A, Member 2"]
["Tretinoin","Nuclear Receptor Subfamily 4, Group A, Member 2",1,0,1,0,"NR4A2","7649469",1995,"9-cis retinoic acid signaling: changing partners causes some excitement.","7649469","Tretinoin","Nuclear Receptor Subfamily 4, Group A, Member 2"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L1668,L1668)","v":"Tretinoin"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M1668,M1668)","v":"PPAR alpha"},1,0,1,1,"PPARA",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K1668,K1668)","v":"22607296"},2012,"Co-treatment with retinyl retinoate and a PPAR? agonist reduces retinoid dermatitis.","22607296","Tretinoin","PPAR alpha"]
["Tretinoin","PPAR alpha",1,0,1,0,"PPARA","16712844",2006,"CYP4A11 is repressed by retinoic acid in human liver cells.","16712844","Tretinoin","PPAR alpha"]
["Tretinoin","PPAR alpha",1,0,1,0,"PPARA","17069763",2006,"Bidirectional CLOCK/BMAL1-dependent circadian gene regulation by retinoic acid in vitro.","17069763","Tretinoin","PPAR alpha"]
["Tretinoin","PPAR alpha",1,0,1,0,"PPARA","16840543",2006,"Remodeling of white adipose tissue after retinoic acid administration in mice.","16840543","Tretinoin","PPAR alpha"]
["Tretinoin","PPAR alpha",1,0,1,0,"PPARA","23821302",2013,"Regulation of URG4/URGCP and PPAR? gene expressions after retinoic acid treatment in neuroblastoma cells.","23821302","Tretinoin","PPAR alpha"]
["Tretinoin","PPAR alpha",1,0,1,0,"PPARA","22871568",2012,"Induction of carnitine palmitoyl transferase 1 and fatty acid oxidation by retinoic acid in HepG2 cells.","22871568","Tretinoin","PPAR alpha"]
["Tretinoin","PPAR alpha",1,0,1,0,"PPARA","19665003",2009,"Statins, fibrates and retinoic acid upregulate mitochondrial acylcarnitine carrier gene expression.","19665003","Tretinoin","PPAR alpha"]
["Tretinoin","PPAR alpha",1,0,1,0,"PPARA","16569247",2006,"In vitro and in vivo effects of the PPAR-alpha agonists fenofibrate and retinoic acid in endometrial cancer.","16569247","Tretinoin","PPAR alpha"]
["Tretinoin","PPAR gamma",1,0,1,0,"PPARG","19669406",2009,"Contrary effects of BMP-2 and ATRA on adipogenesis in mouse mesenchymal fibroblasts.","19669406","Tretinoin","PPAR gamma"]
["Tretinoin","PPAR gamma",1,0,1,0,"PPARG","16982809",2006,"PPARgamma controls CD1d expression by turning on retinoic acid synthesis in developing human dendritic cells.","16982809","Tretinoin","PPAR gamma"]
["Tretinoin","PPAR gamma",1,0,1,0,"PPARG","16513826",2006,"Thiazolidinediones and rexinoids induce peroxisome proliferator-activated receptor-coactivator (PGC)-1alpha gene transcription: an autoregulatory loop controls PGC-1alpha expression in adipocytes via peroxisome proliferator-activated receptor-gamma coactivation.","16513826","Tretinoin","PPAR gamma"]
["Tretinoin","PPAR gamma",1,0,1,0,"PPARG","24038081",2014,"All-trans-retinoic acid ameliorates hepatic steatosis in mice by a novel transcriptional cascade.","24038081","Tretinoin","PPAR gamma"]
["Tretinoin","PPAR gamma",1,0,1,0,"PPARG","16574651",2006,"9-cis-retinoic acid up-regulates expression of transcriptional coregulator PELP1, a novel coactivator of the retinoid X receptor alpha pathway.","16574651","Tretinoin","PPAR gamma"]
["Tretinoin","PPAR gamma",1,0,1,0,"PPARG","19644018",2009,"Combined low doses of PPARgamma and RXR ligands trigger an intrinsic apoptotic pathway in human breast cancer cells.","19644018","Tretinoin","PPAR gamma"]
["Tretinoin","PPAR gamma",1,0,1,0,"PPARG","22261616",2012,"Nuclear receptors agonists exert opposing effects on the inflammation dependent survival of breast cancer stem cells.","22261616","Tretinoin","PPAR gamma"]
["Tretinoin","PPAR gamma",1,0,1,0,"PPARG","23485459",2013,"Molecular mechanism of 9-cis-retinoic acid inhibition of adipogenesis in 3T3-L1 cells.","23485459","Tretinoin","PPAR gamma"]
["Tretinoin","PPAR gamma",1,0,1,0,"PPARG","19018263",2008,"PPARgamma agonists inhibit growth and expansion of CD133+ brain tumour stem cells.","19018263","Tretinoin","PPAR gamma"]
["Tretinoin","PPAR gamma",1,0,1,0,"PPARG","18075297",2007,"PPARgamma-active triterpenoid CDDO enhances ATRA-induced differentiation in APL.","18075297","Tretinoin","PPAR gamma"]
["Tretinoin","PPAR gamma",1,0,1,0,"PPARG","24122898",2014,"The hunt for treatment options of fatty liver continues: effects of retinoic acid on hepatic steatosis reveal novel transcriptional interactions of nuclear receptors.","24122898","Tretinoin","PPAR gamma"]
["Tretinoin","PPAR gamma",1,0,1,0,"PPARG","16963253",2007,"Regulation of adipocyte differentiation by PEGylated all-trans retinoic acid: reduced cytotoxicity and attenuated lipid accumulation.","16963253","Tretinoin","PPAR gamma"]
["Tretinoin","PPAR gamma",1,0,1,0,"PPARG","18594976",2009,"Additive inhibitory effect of experimentally induced hepatic cirrhosis by agonists of peroxisome proliferator activator receptor gamma and retinoic acid receptor.","18594976","Tretinoin","PPAR gamma"]
["Tretinoin","PPAR gamma",1,0,1,0,"PPARG","20081187",2010,"Regulation of neural crest cell fate by the retinoic acid and Pparg signalling pathways.","20081187","Tretinoin","PPAR gamma"]
["Tretinoin","PPAR gamma",1,0,1,0,"PPARG","19861119",2009,"NR4A orphan nuclear receptors influence retinoic acid and docosahexaenoic acid signaling via up-regulation of fatty acid binding protein 5.","19861119","Tretinoin","PPAR gamma"]
["Tretinoin","PPAR gamma",1,0,1,0,"PPARG","15383226",2004,"Effect of retinoic acid on leptin, glycerol, and glucose levels in mature rat adipocytes in vitro.","15383226","Tretinoin","PPAR gamma"]
["Tretinoin","PPAR gamma",1,0,1,0,"PPARG","20154154",2010,"Induction of peroxisomal proliferator-activated receptor gamma and peroxisomal proliferator-activated receptor gamma coactivator 1 by unsaturated fatty acids, retinoic acid, and carotenoids in preadipocytes obtained from bovine white adipose tissue1,2.","20154154","Tretinoin","PPAR gamma"]
["Tretinoin","PPAR gamma",1,0,1,0,"PPARG","20376700",2011,"All-trans- and 9-cis-retinoic acids activate the human cyclooxynase-2 gene: a role for DR1 as RARE or RXRE.","20376700","Tretinoin","PPAR gamma"]
["Tretinoin","PPAR gamma",1,0,1,0,"PPARG","15505623",2004,"Fenretinide stimulates redox-sensitive ceramide production in breast cancer cells: potential role in drug-induced cytotoxicity.","15505623","Tretinoin","PPAR gamma"]
["Tretinoin","PPAR gamma",1,0,1,0,"PPARG","18239600",2008,"Retinoic acid treatment increases lipid oxidation capacity in skeletal muscle of mice.","18239600","Tretinoin","PPAR gamma"]
["Tretinoin","PPAR gamma",1,0,1,0,"PPARG","23319320",2013,"All-trans retinoic acid displays multiple effects on the growth, lipogenesis and adipokine gene expression of AML-I preadipocyte cell line.","23319320","Tretinoin","PPAR gamma"]
["Tretinoin","PPAR gamma",1,0,1,0,"PPARG","20193324",2009,"[Differentiating effect of PPARgamma ligand rosiglitazone and all trans-retinoic acid on myeloma cells and its possible mechanism].","20193324","Tretinoin","PPAR gamma"]
["Tretinoin","PPAR gamma",1,0,1,0,"PPARG","19373597",2009,"Multiple myeloma cells undergo differentiation upon exposure to rosiglitazone and all-trans retinoic acid.","19373597","Tretinoin","PPAR gamma"]
["Tretinoin","PPAR gamma",1,0,1,0,"PPARG","18812638",2008,"Molecular mechanism of protection against chemically and gamma-radiation induced apoptosis in human colon cancer cells.","18812638","Tretinoin","PPAR gamma"]
["Tretinoin","PPAR gamma",1,0,1,0,"PPARG","15583048",2005,"Regulation of differentiating pig preadipocytes by retinoic acid.","15583048","Tretinoin","PPAR gamma"]
["Tretinoin","PPAR gamma",1,0,1,0,"PPARG","24098526",2013,"Amplified inhibition of stellate cell activation pathways by PPAR-?, RAR and RXR agonists.","24098526","Tretinoin","PPAR gamma"]
["Tretinoin","PPAR gamma",1,0,1,0,"PPARG","24059847",2013,"Retinoic acid has different effects on UCP1 expression in mouse and human adipocytes.","24059847","Tretinoin","PPAR gamma"]
["Tretinoin","PPAR gamma",1,0,1,0,"PPARG","23014973",2013,"Retinoic acid regulates commitment of undifferentiated mesenchymal stem cells into osteoblasts and adipocytes.","23014973","Tretinoin","PPAR gamma"]
["Tretinoin","PPAR gamma",1,0,1,0,"PPARG","23583383",2013,"Retinoic acid inhibits adipogenesis via activation of Wnt signaling pathway in 3T3-L1 preadipocytes.","23583383","Tretinoin","PPAR gamma"]
["Tretinoin","PPAR gamma",1,0,1,0,"PPARG","19401386",2009,"PPARgamma regulates retinoic acid-mediated DC induction of Tregs.","19401386","Tretinoin","PPAR gamma"]
["Tretinoin","PPAR gamma",1,0,1,0,"PPARG","19457135",2009,"PPARgamma and RXRgamma ligands act synergistically as potent antineoplastic agents in vitro and in vivo glioma models.","19457135","Tretinoin","PPAR gamma"]
["Tretinoin","PPAR gamma",1,0,1,0,"PPARG","19288012",2009,"Enhanced effects of PPARgamma ligands and RXR selective retinoids in combination to inhibit migration and invasiveness in cancer cells.","19288012","Tretinoin","PPAR gamma"]
["Tretinoin","PPAR gamma",1,0,1,0,"PPARG","23833249",2013,"RDH10, RALDH2, and CRABP2 are required components of PPAR?-directed ATRA synthesis and signaling in human dendritic cells.","23833249","Tretinoin","PPAR gamma"]
["Tretinoin","PPAR gamma",1,0,1,0,"PPARG","23605322",2013,"Combinational effect of PPAR? agonist and RXR agonist on the growth of SGC7901 gastric carcinoma cells in vitro.","23605322","Tretinoin","PPAR gamma"]
["Tretinoin","PPAR gamma",1,0,1,0,"PPARG","17369494",2007,"Catalase potentiates retinoic acid-induced THP-1 monocyte differentiation into macrophage through inhibition of peroxisome proliferator-activated receptor gamma.","17369494","Tretinoin","PPAR gamma"]
["Tretinoin","PPAR gamma",1,0,1,0,"PPARG","21654191",2011,"Bid as a potential target of apoptotic effects exerted by low doses of PPAR? and RXR ligands in breast cancer cells.","21654191","Tretinoin","PPAR gamma"]
["Tretinoin","PPAR gamma",1,0,1,0,"PPARG","19467017",2009,"All-trans retinoic acid can intensify the growth inhibition and differentiation induction effect of rosiglitazone on multiple myeloma cells.","19467017","Tretinoin","PPAR gamma"]
["Tretinoin","PPAR gamma",1,0,1,0,"PPARG","23833373",2013,"Anti-inflammatory and anti-hyperalgesic effect of all-trans retinoic acid in carrageenan-induced paw edema in Wistar rats: involvement of peroxisome proliferator-activated receptor-?/? receptors.","23833373","Tretinoin","PPAR gamma"]
["Tretinoin","PPAR gamma",1,0,1,0,"PPARG","21704731",2012,"The contribution of vitamin A to autocrine regulation of fat depots.","21704731","Tretinoin","PPAR gamma"]
["Tretinoin","PPAR gamma",1,0,1,0,"PPARG","17475839",2007,"9-cis-Retinoic acid (9cRA), a retinoid X receptor (RXR) ligand, exerts immunosuppressive effects on dendritic cells by RXR-dependent activation: inhibition of peroxisome proliferator-activated receptor gamma blocks some of the 9cRA activities, and precludes them to mature phenotype development.","17475839","Tretinoin","PPAR gamma"]
["Tretinoin","PPAR gamma",1,0,1,0,"PPARG","15850670",2005,"Hormone regulation of microglial cell activation: relevance to multiple sclerosis.","15850670","Tretinoin","PPAR gamma"]
["Tretinoin","PPAR gamma",1,0,1,0,"PPARG","17674773",2007,"[The role of 9-cisRA in the regulation of pig preadipocyte differentiation].","17674773","Tretinoin","PPAR gamma"]
["Tretinoin","PPAR gamma",1,0,1,0,"PPARG","15717660",2004,"Novel medical approaches for the treatment of Cushing's disease.","15717660","Tretinoin","PPAR gamma"]
["Tretinoin","PPAR gamma",1,0,1,0,"PPARG","17604322",2007,"Synergistic effects of RXR alpha and PPAR gamma ligands to inhibit growth in human colon cancer cells--phosphorylated RXR alpha is a critical target for colon cancer management.","17604322","Tretinoin","PPAR gamma"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","11778229",2000,"[Mechanism of retinoic acid receptor alpha-mediated growth inhibition of gastric cancer cells by all-trans retinoic acid].","11778229","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","24310731",2013,"Effects of all-trans retinoic acid, retinol, and ?-carotene on murine macrophage activity.","24310731","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","19341714",2009,"The Ski protein can inhibit ligand induced RARalpha and HDAC3 degradation in the retinoic acid signaling pathway.","19341714","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","19302235",2010,"Apoptosis inducing and differentiation enhancement effect of oridonin on the all-trans-retinoic acid-sensitive and -resistant acute promyelocytic leukemia cells.","19302235","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","11313705",2001,"A functionally active RARalpha nuclear receptor is expressed in retinoic acid non responsive early myeloblastic cell lines.","11313705","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","23693014",2013,"Activation of Akt pathway by transcription-independent mechanisms of retinoic acid promotes survival and invasion in lung cancer cells.","23693014","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","11331070",2001,"Involvement of all-trans-retinoic acid in the breakdown of retinoic acid receptors alpha and gamma through proteasomes in MCF-7 human breast cancer cells.","11331070","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","11342454",2001,"Tyrosine kinase inhibitor STI571 potentiates the pharmacologic activity of retinoic acid in acute promyelocytic leukemia cells: effects on the degradation of RARalpha and PML-RARalpha.","11342454","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","10051583",1999,"Ligand-dependent activation of transcription in vitro by retinoic acid receptor alpha/retinoid X receptor alpha heterodimers that mimics transactivation by retinoids in vivo.","10051583","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","11751425",2001,"Overexpression of retinoic acid receptors alpha and gamma into neoplastic epidermal cells causes retinoic acid-induced growth arrest and apoptosis.","11751425","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,1,"RARA","15899384",2005,"Acute promyelocytic leukemia with PML-RARA fusion on i(17q) and therapy-related acute myeloid leukemia.","15899384","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","19279407",2009,"Mechanisms underlying the induction of the putative human tumor suppressor GPRC5A by retinoic acid.","19279407","Tretinoin","retinoic acid receptor alpha"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L1732,L1732)","v":"Tretinoin"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M1732,M1732)","v":"retinoic acid receptor alpha"},1,0,1,0,"RARA",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K1732,K1732)","v":"18641199"},2008,"Retinoic acid decreases adherence of murine myeloid dendritic cells and increases production of matrix metalloproteinase-9.","18641199","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","10199796",1999,"Changes in tissue transglutaminase activity and expression during retinoic acid-induced growth arrest and apoptosis in primary cultures of human epithelial prostate cells.","10199796","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","24204796",2013,"All-trans retinoic acid modulates ORMDL3 expression via transcriptional regulation.","24204796","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","16235736",2005,"Inhibitory effect of all-trans retinoic acid on androgen-induced growth of mouse seminal vesicles in vivo and its mechanism.","16235736","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","16210368",2006,"Retinoic acid metabolism and signaling pathways in the adult and developing mouse testis.","16210368","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","16178010",2006,"Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARalpha and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways.","16178010","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","10023688",1999,"Retinoic acid, but not arsenic trioxide, degrades the PLZF/RARalpha fusion protein, without inducing terminal differentiation or apoptosis, in a RA-therapy resistant t(11;17)(q23;q21) APL patient.","10023688","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","11333911",2001,"Polyomavirus small t antigen prevents retinoic acid-induced retinoblastoma protein hypophosphorylation and redirects retinoic acid-induced G0 arrest and differentiation to apoptosis.","11333911","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","19345331",2009,"ZNF423 is critically required for retinoic acid-induced differentiation and is a marker of neuroblastoma outcome.","19345331","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","15867260",2005,"Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.","15867260","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","11212271",2001,"Granulocytic differentiation of human NB4 promyelocytic leukemia cells induced by all-trans retinoic acid metabolites.","11212271","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","23792233",2013,"Involvement of retinoic acid-induced peroxiredoxin 6 expression in recovery of noise-induced temporary hearing threshold shifts.","23792233","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","11327309",2000,"Characterization of a retinoic acid responsive element in the human ets-1 promoter.","11327309","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","11212249",2001,"Increased retinoic acid responsiveness in lung carcinoma cells that are nonresponsive despite the presence of endogenous retinoic acid receptor (RAR) beta by expression of exogenous retinoid receptors retinoid X receptor alpha, RAR alpha, and RAR gamma.","11212249","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","11211936",2001,"Retinoic acid-induced blr1 expression requires RARalpha, RXR, and MAPK activation and uses ERK2 but not JNK/SAPK to accelerate cell differentiation.","11211936","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","16251210",2005,"Retinoic acid regulates the expression of dorsoventral topographic guidance molecules in the chick retina.","16251210","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","17069763",2006,"Bidirectional CLOCK/BMAL1-dependent circadian gene regulation by retinoic acid in vitro.","17069763","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","11501968",2001,"ATRA(ouble) in the treatment of acute promyelocytic leukemia.","11501968","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","11173543",2001,"Overexpression of retinoic acid receptor beta induces growth arrest and apoptosis in oral cancer cell lines.","11173543","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","11683493",2001,"Retinoic acid causes MEK-dependent RAF phosphorylation through RARalpha plus RXR activation in HL-60 cells.","11683493","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,1,"RARA","10225456",1999,"Induction of cell-cycle arrest and apoptosis by a novel retinobenzoic-acid derivative, TAC-101, in human pancreatic-cancer cells.","10225456","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","15949693",2005,"Effects of retinoic acid administration and dietary vitamin A supplementation on leptin expression in mice: lack of correlation with changes of adipose tissue mass and food intake.","15949693","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","23843516",2013,"Rapid suppression of inhibitory synaptic transmission by retinoic acid.","23843516","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","19155306",2009,"Inhibition of the peptidyl-prolyl-isomerase Pin1 enhances the responses of acute myeloid leukemia cells to retinoic acid via stabilization of RARalpha and PML-RARalpha.","19155306","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","11741944",2002,"Oxysterol activators of liver X receptor and 9-cis-retinoic acid promote sequential steps in the synthesis and secretion of tumor necrosis factor-alpha from human monocytes.","11741944","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,1,"RARA","11600603",2001,"Extramedullary involvement at relapse in acute promyelocytic leukemia patients treated or not with all-trans retinoic acid: a report by the Gruppo Italiano Malattie Ematologiche dell'Adulto.","11600603","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","24038081",2014,"All-trans-retinoic acid ameliorates hepatic steatosis in mice by a novel transcriptional cascade.","24038081","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","19029830",2008,"Trim24 (Tif1 alpha): an essential 'brake' for retinoic acid-induced transcription to prevent liver cancer.","19029830","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","23977003",2013,"Allergen-induced dermatitis causes alterations in cutaneous retinoid-mediated signaling in mice.","23977003","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","19073915",2008,"Retinoic acid-gated sequence-specific translational control by RARalpha.","19073915","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","10077004",1999,"Defective retinoic acid regulation of the Pit-1 gene enhancer: a novel mechanism of combined pituitary hormone deficiency.","10077004","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","11555654",2001,"Inhibition of 20 S and 26 S proteasome activity by lithium chloride: impact on the differentiation of leukemia cells by all-trans retinoic acid.","11555654","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","11587360",2001,"Histone deacetylases and transcriptional therapy with their inhibitors.","11587360","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","19114071",2009,"Involvement of retinoic acid signaling in goldfish optic nerve regeneration.","19114071","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","11493540",2001,"Hindbrain patterning involves graded responses to retinoic acid signalling.","11493540","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","16044313",2005,"AML bearing the translocation t(11;17)(q23;q21): involvement of MLL and a region close to RARA, with no differentiation response to retinoic acid.","16044313","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","16968653",2007,"Designed ATRA analogue active against ATRA-resistant acute promyelocytic leukemia cells having a single nucleotide substitution in their retinoic acid receptor.","16968653","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","16140955",2005,"Benzodithiophenes potentiate differentiation of acute promyelocytic leukemia cells by lowering the threshold for ligand-mediated corepressor/coactivator exchange with retinoic acid receptor alpha and enhancing changes in all-trans-retinoic acid-regulated gene expression.","16140955","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","19006694",2008,"Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells.","19006694","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","11397803",2001,"Regulation of stearoyl coenzyme A desaturase expression in human retinal pigment epithelial cells by retinoic acid.","11397803","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","10075925",1999,"Identification of heparin-binding EGF-like growth factor as a target in intercellular regulation of epidermal basal cell growth by suprabasal retinoic acid receptors.","10075925","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","23830798",2013,"Retinoic acid receptor alpha amplifications and retinoic acid sensitivity in breast cancers.","23830798","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","11403920",2001,"Chemoprevention of NMU-induced rat mammary carcinoma with the combination of melatonin and 9-cis-retinoic acid.","11403920","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","16007204",2005,"Synergistic induction of the MUC4 mucin gene by interferon-gamma and retinoic acid in human pancreatic tumour cells involves a reprogramming of signalling pathways.","16007204","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","18957222",2008,"Synaptic signaling by all-trans retinoic acid in homeostatic synaptic plasticity.","18957222","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","24023268",2013,"Aromatase activity induction in human adipose fibroblasts by retinoic acids via retinoic acid receptor ?.","24023268","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","24043786",2013,"Regulation of human hematopoietic stem cell self-renewal by the microenvironment's control of retinoic acid signaling.","24043786","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","16979153",2006,"Retinoic acid signalling is required for specification of pronephric cell fate.","16979153","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","15924754",2005,"[Effect of retinoic acid on the development of B cells from lymph nodes of young children and the pathway of the effect].","15924754","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","11704841",2001,"APL, a model disease for cancer therapies?","11704841","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","16038797",2005,"Phosphorylation of the retinoid x receptor at the omega loop, modulates the expression of retinoic-acid-target genes with a promoter context specificity.","16038797","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","10071126",1999,"A unique carboxy-terminus truncation mutant of the retinoic acid receptor alpha gene associated with a variant marker chromosome in a retinoic acid resistant HL-60 subline.","10071126","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","18840692",2008,"Retinoic acid regulates RARalpha-mediated control of translation in dendritic RNA granules during homeostatic synaptic plasticity.","18840692","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","11424005",2001,"Retinoic acid dramatically enhances the arsenic trioxide-induced cell cycle arrest and apoptosis in retinoic acid receptor alpha-positive human T-cell lymphotropic virus type-I-transformed cells.","11424005","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","10760826",2000,"Retinoic acid induces persistent, RARalpha-mediated anti-proliferative responses in Epstein-Barr virus-immortalized b lymphoblasts carrying an activated C-MYC oncogene but not in Burkitt's lymphoma cell lines.","10760826","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","11038749",1997,"[Inhibition of estrogen receptor-positive human breast carcinoma cell growth by retinoic acid].","11038749","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","10660115",2000,"Differential effects of retinoic acid on growth and apoptosis in human colon cancer cell lines associated with the induction of retinoic acid receptor beta.","10660115","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","10660575",2000,"Follicle-stimulating hormone inhibits all-trans-retinoic acid-induced retinoic acid receptor alpha nuclear localization and transcriptional activation in mouse Sertoli cell lines.","10660575","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","16919330",2007,"New chemical strategies for overcoming ATRA resistance in APL cells.","16919330","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","10673742",2000,"A mutated PML/RARA found in the retinoid maturation resistant NB4 subclone, NB4-R2, blocks RARA and wild-type PML/RARA transcriptional activities.","10673742","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","10673743",2000,"Arsenic trioxide-induced apoptosis and differentiation are associated respectively with mitochondrial transmembrane potential collapse and retinoic acid signaling pathways in acute promyelocytic leukemia.","10673743","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","10684250",2000,"Regulation of skeletal progenitor differentiation by the BMP and retinoid signaling pathways.","10684250","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","10699072",2000,"A ligand of peroxisome proliferator-activated receptor gamma, retinoids, and prevention of preneoplastic mammary lesions.","10699072","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","17595318",2007,"Rapid, nongenomic actions of retinoic acid on phosphatidylinositol-3-kinase signaling pathway mediated by the retinoic acid receptor.","17595318","Tretinoin","retinoic acid receptor alpha"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L1796,L1796)","v":"Tretinoin"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M1796,M1796)","v":"retinoic acid receptor alpha"},1,0,1,0,"RARA",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K1796,K1796)","v":"17182884"},2007,"Retinoic acid inhibits HIV-1-induced podocyte proliferation through the cAMP pathway.","17182884","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","17712061",2008,"All-trans-retinoic acid stimulates translation and induces spine formation in hippocampal neurons through a membrane-associated RARalpha.","17712061","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","16757381",2006,"Retinoic acids and trichostatin A (TSA), a histone deacetylase inhibitor, induce human pyruvate dehydrogenase kinase 4 (PDK4) gene expression.","16757381","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","10772914",2000,"Retinoic acid inhibits nitric oxide synthase-2 expression through the retinoic acid receptor-alpha.","10772914","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","10779427",2000,"Retinoic acid is a negative regulator for the differentiation of cord blood-derived human mast cell progenitors.","10779427","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","17785809",2007,"Vitamin A metabolites induce gut-homing FoxP3+ regulatory T cells.","17785809","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","10785230",2000,"Retinoic acid suppresses interleukin-6 production in human endometrial cells.","10785230","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","17786207",2007,"Disruption of retinoic acid receptor alpha reveals the growth promoter face of retinoic acid.","17786207","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","10799323",2000,"Differential regulation of the carbonic anhydrase II gene expression by hormonal nuclear receptors in monocytic cells: identification of the retinoic acid response element.","10799323","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","17825229",2007,"[Effects of arsenic trioxide and ATRA on PLZF-RARalpha-positive U937 leukemic cells].","17825229","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","16636311",2006,"Retinoic acid exerts dual regulatory actions on the expression and nuclear localization of interferon regulatory factor-1.","16636311","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","17933214",2007,"Retinoic acid inducibility of the human PDGF-a gene is mediated by 5'-distal DNA motifs that overlap with basal enhancer and vitamin D response elements.","17933214","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","17951529",2008,"Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway.","17951529","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","17693386",2007,"Rat hepatic stellate cells acquire retinoid responsiveness after activation in vitro by post-transcriptional regulation of retinoic acid receptor alpha gene expression.","17693386","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","16788101",2006,"CCAAT/enhancer binding proteins alpha and epsilon cooperate with all-trans retinoic acid in therapy but differ in their antileukemic activities.","16788101","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","10446999",1999,"Induction of a functional vitamin D receptor in all-trans-retinoic acid-induced monocytic differentiation of M2-type leukemic blast cells.","10446999","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","17283134",2007,"Knockdown of XAB2 enhances all-trans retinoic acid-induced cellular differentiation in all-trans retinoic acid-sensitive and -resistant cancer cells.","17283134","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","10452855",1999,"Retinoic acid signaling is necessary for the development of the organ of Corti.","10452855","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","17291686",2007,"Expression, protein stability and transcriptional activity of retinoic acid receptors are affected by microtubules interfering agents and all-trans-retinoic acid in primary rat hepatocytes.","17291686","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","17306764",2007,"Retinoic acid activates human inducible nitric oxide synthase gene through binding of RARalpha/RXRalpha heterodimer to a novel retinoic acid response element in the promoter.","17306764","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","16872382",2006,"Effect of all-trans-retinoic acid on the differentiation, maturation and functions of dendritic cells derived from cord blood monocytes.","16872382","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","17363914",2007,"Immunolocalization of enzymes, binding proteins, and receptors sufficient for retinoic acid synthesis and signaling during the hair cycle.","17363914","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","16840198",2006,"Single-agent liposomal all-trans retinoic acid can cure some patients with untreated acute promyelocytic leukemia: an update of The University of Texas M. D. Anderson Cancer Center Series.","16840198","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","10429659",1999,"Characterization of two novel retinoic acid-resistant cell lines derived from HL-60 cells following long-term culture with all-trans-retinoic acid.","10429659","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","10652610",1999,"Retinoic acid modulates RAR alpha and RAR beta receptors in human glioma cell lines.","10652610","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","17392484",2007,"Retinoic acid regulates CD1d gene expression at the transcriptional level in human and rodent monocytic cells.","17392484","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","16594593",2006,"Relationship between retinoic acid receptor alpha gene expression and growth-inhibitory effect of all-trans retinoic acid on canine tumor cells.","16594593","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","16782888",2006,"Btg2 enhances retinoic acid-induced differentiation by modulating histone H4 methylation and acetylation.","16782888","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","10582693",1999,"Human uterine leiomyomata express higher levels of peroxisome proliferator-activated receptor gamma, retinoid X receptor alpha, and all-trans retinoic acid than myometrium.","10582693","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","17454588",2007,"Acute promyelocytic leukemia: a novel PML/RARalpha fusion that generates a frameshift in the RARalpha transcript and ATRA resistance.","17454588","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","17460283",2007,"Inhibitory effects of retinoic acid receptor alpha stimulants on murine cataractogenesis through suppression of deregulated calpains.","17460283","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","16778211",2006,"Apoptosis induction by retinoids in eosinophilic leukemia cells: implication of retinoic acid receptor-alpha signaling in all-trans-retinoic acid hypersensitivity.","16778211","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","16768108",2006,"[Mouse NASH model using retinoic acid receptor alpha].","16768108","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","16766008",2006,"Enhancement of caffeic acid phenethyl ester on all-trans retinoic acid-induced differentiation in human leukemia HL-60 cells.","16766008","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","10611294",1999,"Retinoic acid induces proteasome-dependent degradation of retinoic acid receptor alpha (RARalpha) and oncogenic RARalpha fusion proteins.","10611294","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","16765349",2006,"Increased p21 expression and complex formation with cyclin E/CDK2 in retinoid-induced pre-B lymphoma cell apoptosis.","16765349","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","10617585",2000,"Retinoic acid stimulation of the human surfactant protein B promoter is thyroid transcription factor 1 site-dependent.","10617585","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","17387344",2007,"Novel retinoic acid metabolism blocking agents have potent inhibitory activities on human breast cancer cells and tumour growth.","17387344","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","18500361",2008,"Auranofin promotes retinoic acid- or dihydroxyvitamin D3-mediated cell differentiation of promyelocytic leukaemia cells by increasing histone acetylation.","18500361","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","18373956",2008,"Hepatic biotransformation responses in Atlantic salmon exposed to retinoic acids and 3,3',4,4'-tetrachlorobiphenyl (PCB congener 77).","18373956","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","24504403",2014,"Engaging a senescent response to cure leukemia.","24504403","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","10995752",2000,"Feedback inhibition of the retinaldehyde dehydrogenase gene ALDH1 by retinoic acid through retinoic acid receptor alpha and CCAAT/enhancer-binding protein beta.","10995752","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","24503130",2014,"Increased production of retinoic acid by intestinal macrophages contributes to their inflammatory phenotype in patients with Crohn's disease.","24503130","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","18466769",2008,"Acyclic retinoid inhibits functional interaction of transcription factors Krüppel-like factor 5 and retinoic acid receptor-alpha.","18466769","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","16329108",2006,"Retinoic acid-induced CD38 expression in HL-60 myeloblastic leukemia cells regulates cell differentiation or viability depending on expression levels.","16329108","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","24495389",2014,"Effect of all-trans-retinoic acid on enterovirus 71 infection in vitro.","24495389","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","24490497",2013,"[Effect of recombinant adenovirus carrying NLS-RARalpha gene on the proliferation of HL-60 cell and the differentiation of HL-60 cells induced by ATRA and relevant mechanism].","24490497","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","11022230",2000,"Mechanisms of all-trans retinoic acid-induced differentiation of acute promyelocytic leukemia cells.","11022230","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","17968018",2007,"A functional genetic screen identifies retinoic acid signaling as a target of histone deacetylase inhibitors.","17968018","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","18497940",2008,"ERAP140/Nbla10993 is a novel favorable prognostic indicator for neuroblastoma induced in response to retinoic acid.","18497940","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","16449964",2006,"Co-resistance to retinoic acid and TRAIL by insertion mutagenesis into RAM.","16449964","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","16302920",2005,"Retinoic acid is a potential negative regulator for differentiation of human periodontal ligament cells.","16302920","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","11058598",2001,"Retinoic acid-mediated activation of the mouse renin enhancer.","11058598","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","18539269",2008,"Impairing retinoic acid signalling in the neural crest cells is sufficient to alter entire eye morphogenesis.","18539269","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","16289102",2005,"Retinoic acid via RARalpha inhibits the expression of 24-hydroxylase in human prostate stromal cells.","16289102","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","16287870",2005,"Impaired retinoic acid (RA) signal leads to RARbeta2 epigenetic silencing and RA resistance.","16287870","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","11114157",2000,"Direct gating by retinoic acid of retinal electrical synapses.","11114157","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","24412926",2014,"Activation of a promyelocytic leukemia-tumor protein 53 axis underlies acute promyelocytic leukemia cure.","24412926","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","24394593",2014,"A TDG/CBP/RAR? ternary complex mediates the retinoic acid-dependent expression of DNA methylation-sensitive genes.","24394593","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","17164434",2007,"Retinoids induce MMP-9 expression through RARalpha during mammary gland remodeling.","17164434","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,1,"RARA","24346134",2013,"All-trans retinoic acid-induced hypothalamus-pituitary-adrenal hyperactivity involves glucocorticoid receptor dysregulation.","24346134","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","11027432",2000,"Loss of growth inhibitory effects of retinoic acid in human breast cancer cells following long-term exposure to retinoic acid.","11027432","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","18212063",2008,"Topoisomerase IIbeta negatively modulates retinoic acid receptor alpha function: a novel mechanism of retinoic acid resistance.","18212063","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","10222420",1999,"Paucity of retinoic acid receptor alpha (RAR alpha) nuclear immunostaining in gliomas and inability of retinoic acid to influence neural cell adhesion molecule (NCAM) expression.","10222420","Tretinoin","retinoic acid receptor alpha"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L1860,L1860)","v":"Tretinoin"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M1860,M1860)","v":"retinoic acid receptor alpha"},1,0,1,0,"RARA",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K1860,K1860)","v":"10860554"},2000,"Promoter activity and regulation of the CYP4F2 leukotriene B(4) omega-hydroxylase gene by peroxisomal proliferators and retinoic acid in HepG2 cells.","10860554","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","18048326",2007,"Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha.","18048326","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","10869350",2000,"Dimerization with retinoid X receptors and phosphorylation modulate the retinoic acid-induced degradation of retinoic acid receptors alpha and gamma through the ubiquitin-proteasome pathway.","10869350","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","10872810",2000,"Retinoic acid switches differential expression of FGF8 isoforms in LNCaP cells.","10872810","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","25071154",2014,"Role of UTX in retinoic acid receptor-mediated gene regulation in leukemia.","25071154","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","10388516",1999,"The HNF-3alpha transcription factor is a primary target for retinoic acid action.","10388516","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","10364250",1999,"Signal relay by retinoic acid receptors alpha and beta in the retinoic acid-induced expression of insulin-like growth factor-binding protein-3 in breast cancer cells.","10364250","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","10364073",1999,"Retinoic acid regulates arterial smooth muscle cell proliferation and phenotypic features in vivo and in vitro through an RARalpha-dependent signaling pathway.","10364073","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","25003661",2014,"Retinoic acid synergizes ATO-mediated cytotoxicity by precluding Nrf2 activity in AML cells.","25003661","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","10225671",1999,"Acute myelogenous leukemia with a t(2;17;4)(p13;q21;p16) aberration: effective treatment with all-trans retinoic acid and granulocyte colony-stimulating factor.","10225671","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","10360373",1999,"Atypical response to all-trans retinoic acid in a der(5)t(5;17) acute promyelocytic leukemia.","10360373","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","19144644",2009,"SUG-1 plays proteolytic and non-proteolytic roles in the control of retinoic acid target genes via its interaction with SRC-3.","19144644","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","10910773",2000,"The conserved amphipatic alpha-helical core motif of RARgamma and RARalpha activating domains is indispensable for RA-induced differentiation of F9 cells.","10910773","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","24819975",2014,"Small ubiquitin-related modifier-1 modification regulates all-trans-retinoic acid-induced differentiation via stabilization of retinoic acid receptor ?.","24819975","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","10921005",1998,"[Binding activity of retinoids with recombinant human retinoic acid receptor RAR alpha].","10921005","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","10933889",2000,"Role of Ser(289) in RARgamma and its homologous amino acid residue of RARalpha and RARbeta in the binding of retinoic acid.","10933889","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","10344761",1999,"Expression and up-regulation of retinoic acid receptor-beta is associated with retinoid sensitivity and colony formation in esophageal cancer cell lines.","10344761","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","10938282",2000,"Retinoic acid-dependent transforming growth factor-beta 2-mediated induction of MUC4 mucin expression in human pancreatic tumor cells follows retinoic acid receptor-alpha signaling pathway.","10938282","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","16456186",2006,"Retinoic acid inhibits airway smooth muscle cell migration.","16456186","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","24646031",2014,"Role of cell cycle regulatory molecules in retinoic acid- and vitamin D3-induced differentiation of acute myeloid leukaemia cells.","24646031","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","10945012",2000,"[Treatment of acute promyelocytic leukemia with all-trans retinoic acid and chemotherapy--multicenter trial of the Japan Adult Leukemia Study Group (JALSG)].","10945012","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","10828828",2000,"Critical role of the H6-H7 loop in the conformational adaptation of all-trans retinoic acid and synthetic retinoids within the ligand-binding site of RARalpha.","10828828","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","10896783",2000,"Retinoic acid-mediated G1 arrest is associated with induction of p27(Kip1) and inhibition of cyclin-dependent kinase 3 in human lung squamous carcinoma CH27 cells.","10896783","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","15194426",2004,"Retinoic acid regulates cell cycle progression and cell differentiation in human monocytic THP-1 cells.","15194426","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","20190807",2010,"Retinoid-suppressed phosphorylation of RARalpha mediates the differentiation pathway of osteosarcoma cells.","20190807","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","15345685",2004,"Retinoid-modulated MAT1 ubiquitination and CAK activity.","15345685","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","15339853",2005,"Retinoids and myelomonocytic growth factors cooperatively activate RARA and induce human myeloid leukemia cell differentiation via MAP kinase pathways.","15339853","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","19375825",2009,"Effect of conjugates of all-trans-retinoic acid and shorter polyene chain analogues with amino acids on prostate cancer cell growth.","19375825","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","15305858",2004,"Disruption of the retinoid signalling pathway causes a deposition of amyloid beta in the adult rat brain.","15305858","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","15964596",2005,"Developmental changes of the expression of the genes regulated by retinoic acid in the small intestine of rats.","15964596","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","22982681",2012,"CAC1 negatively regulates RAR? activity through cooperation with HDAC.","22982681","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","12435367",2002,"A role for retinoic acid in regulating the regeneration of deer antlers.","12435367","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","15291362",2004,"Granulocytic differentiation of leukemic cells with t(9;11)(p22;q23) induced by all-trans-retinoic acid.","15291362","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","22778276",2012,"The cell biology of disease: Acute promyelocytic leukemia, arsenic, and PML bodies.","22778276","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","12505260",2002,"Atypical t(15;17)(q13;q12) in a patient with all-trans retinoic acid refractory secondary acute promyelocytic leukemia: a case report and review of the literature.","12505260","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","12353219",2002,"Retinoic acid signaling at sites of plasticity in the mature central nervous system.","12353219","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","12515718",2003,"Enhancement of ATRA-induced cell differentiation by inhibition of calcium accumulation into the endoplasmic reticulum: cross-talk between RAR alpha and calcium-dependent signaling.","12515718","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","20562004",2010,"All-trans retinoic acid enhances the transport of phase II metabolites of benzo[a]pyrene by inducing the Breast Cancer Resistance Protein expression in Caco-2 cells.","20562004","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","15161940",2004,"Non-genomic regulation of transmitter release by retinoic acid at developing motoneurons in Xenopus cell culture.","15161940","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","20681018",2010,"The retinoid signaling pathway inhibits hematopoiesis and uncouples from the Hox genes during hematopoietic development.","20681018","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","20689834",2010,"Retinoic acids potentiate BMP9-induced osteogenic differentiation of mesenchymal progenitor cells.","20689834","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","20739655",2010,"Pharicin B stabilizes retinoic acid receptor-? and presents synergistic differentiation induction with ATRA in myeloid leukemic cells.","20739655","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","15128657",2004,"Multiple points of interaction between retinoic acid and FGF signaling during embryonic axis formation.","15128657","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","20826193",2010,"Inhibition of the redox function of APE1/Ref-1 in myeloid leukemia cell lines results in a hypersensitive response to retinoic acid-induced differentiation and apoptosis.","20826193","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","12080040",2002,"The anti-estrogenic effect of all-trans-retinoic acid on the breast cancer cell line MCF-7 is dependent on HES-1 expression.","12080040","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","15256426",2004,"Combination of retinoic acid and tumor necrosis factor overcomes the maturation block in a variety of retinoic acid-resistant acute promyelocytic leukemia cells.","15256426","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","19934264",2010,"Reciprocal roles of SIRT1 and SKIP in the regulation of RAR activity: implication in the retinoic acid-induced neuronal differentiation of P19 cells.","19934264","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","23352986",2013,"Differential regulation of drug transporter expression by all-trans retinoic acid in hepatoma HepaRG cells and human hepatocytes.","23352986","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","19737861",2009,"Retinoic acid can enhance conversion of naive into regulatory T cells independently of secreted cytokines.","19737861","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","19843631",2009,"UNC45A confers resistance to histone deacetylase inhibitors and retinoic acid.","19843631","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","23321499",2013,"Zyxin cooperates with PTOV1 to confer retinoic acid resistance by repressing RAR activity.","23321499","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","15520197",2004,"Retinoic acid induces neuroblastoma cell death by inhibiting proteasomal degradation of retinoic acid receptor alpha.","15520197","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","23271512",2013,"All-trans retinoic acid and arsenic trioxide resistance of acute promyelocytic leukemia with the variant STAT5B-RARA fusion gene.","23271512","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","19903244",2010,"ATRA inhibits ceramide kinase transcription in a human neuroblastoma cell line, SH-SY5Y cells: the role of COUP-TFI.","19903244","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","23270606",2014,"Synaptic retinoic acid signaling and homeostatic synaptic plasticity.","23270606","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","19917671",2010,"Loss of CAK phosphorylation of RAR{alpha} mediates transcriptional control of retinoid-induced cancer cell differentiation.","19917671","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","15358589",2004,"Molecular mechanisms of chemoprevention and therapy of cancer by retinoids.","15358589","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","12149644",2002,"Her2/neu induces all-trans retinoic acid (ATRA) resistance in breast cancer cells.","12149644","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","12360493",2002,"Retinoid signaling controls mouse pancreatic exocrine lineage selection through epithelial-mesenchymal interactions.","12360493","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","12169446",2002,"Enhancement of the inducible NO synthase activation by retinoic acid is mimicked by RARalpha agonist in vivo.","12169446","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","12186877",2002,"Transcriptional induction of mitogen-activated protein kinase phosphatase 1 by retinoids. Selective roles of nuclear receptors and contribution to the antiapoptotic effect.","12186877","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","23228968",2013,"ATRA and the specific RAR? agonist, NRX195183, have opposing effects on the clonogenicity of pre-leukemic murine AML1-ETO bone marrow cells.","23228968","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","20075418",2010,"Retinoic acid modulates the subcellular localization of small ubiquitin-related modifier-2/3 (SUMO-2/3) in the testis.","20075418","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","23178525",2013,"Effect of an all-trans-retinoic acid conjugate with spermine on viability of human prostate cancer and endothelial cells in vitro and angiogenesis in vivo.","23178525","Tretinoin","retinoic acid receptor alpha"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L1924,L1924)","v":"Tretinoin"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M1924,M1924)","v":"retinoic acid receptor alpha"},1,0,1,0,"RARA",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K1924,K1924)","v":"20107170"},2010,"Retinoic acid receptor (RAR)-alpha is not critically required for mediating retinoic acid effects in the developing mouse retina.","20107170","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","23102850",2013,"Retinoic acid signaling biomarkers after treatment with retinoic acid and retinoic acid receptor alpha antagonist (Ro 41-5253) in canine testis: an in vitro organ culture study.","23102850","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","23095883",2012,"Retinoic acid signaling in Sertoli cells regulates organization of the blood-testis barrier through cyclical changes in gene expression.","23095883","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","23087051",2013,"Retinoic acid rescues alveolar hypoplasia in the calorie-restricted developing rat lung.","23087051","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","15108357",2004,"Tissue-specific regulation of leptin expression and secretion by all-trans retinoic acid.","15108357","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","23243061",2013,"Bortezomib sensitizes human acute myeloid leukemia cells to all-trans-retinoic acid-induced differentiation by modifying the RAR?/STAT1 axis.","23243061","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","21807577",2011,"Retinoic acid drives aryl hydrocarbon receptor expression and is instrumental to dioxin-induced toxicity during palate development.","21807577","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","14668795",2003,"Retinoic acid receptor alpha and retinoid-X receptor-specific agonists synergistically target telomerase expression and induce tumor cell death.","14668795","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","14614773",2003,"Bovine cumulus-granulosa cells contain biologically active retinoid receptors that can respond to retinoic acid.","14614773","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","14613895",2004,"Retinoic acid inhibits rat XY gonad development by blocking mesonephric cell migration and decreasing the number of gonocytes.","14613895","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","14592536",2004,"Distinct role and functional mode of TR3 and RARalpha in mediating ATRA-induced signalling pathway in breast and gastric cancer cells.","14592536","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","21684744",2011,"A transcription factor hijacking to regulate RAR? by using a chimeric molecule of retinoic acid and a DNA alkylator.","21684744","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","14559998",2003,"Modulation of retinoid signaling by a cytoplasmic viral protein via sequestration of Sp110b, a potent transcriptional corepressor of retinoic acid receptor, from the nucleus.","14559998","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","22374532",2012,"[Successful treatment of acute promyelocytic leukemia complicated with autoimmune hepatitis-induced portal hypertension with all-trans retinoic acid].","22374532","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","22366926",2012,"The p85? regulatory subunit of PI3K mediates cAMP-PKA and retinoic acid             biological effects on MCF7 cell growth and migration.","22366926","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","22354841",2012,"RIPPLY3 is a retinoic acid-inducible repressor required for setting the borders of the pre-placodal ectoderm.","22354841","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","22790594",2012,"DHRS3, a retinal reductase, is differentially regulated by retinoic acid and lipopolysaccharide-induced inflammation in THP-1 cells and rat liver.","22790594","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","22337869",2012,"Retinoic acid receptor ? mediates all-trans-retinoic acid-induced Klf4 gene expression by regulating Klf4 promoter activity in vascular smooth muscle cells.","22337869","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","12671705",2003,"Tyrosine-kinase expression profiles in human gastric cancer cell lines and their modulations with retinoic acids.","12671705","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","22311672",2012,"Retinoic acid/alpha-interferon combination inhibits growth and promotes apoptosis in mantle cell lymphoma through Akt-dependent modulation of critical targets.","22311672","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","21821978",2011,"[All-trans retinoic acid and arsenic trioxide: their molecular mechanisms of action and updated clinical progress in APL therapy].","21821978","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","22190473",2012,"Identification and characterization of a novel retinoic acid response element in zebrafish cyp26a1 promoter.","22190473","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","21878117",2011,"Plasticity of photoreceptor-generating retinal progenitors revealed by prolonged retinoic acid exposure.","21878117","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","22177959",2012,"All-trans retinoic acid inhibits the recruitment of ARNT to DNA, resulting in the decrease of CYP1A1 mRNA expression in HepG2 cells.","22177959","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","12970771",2003,"Retinoid target genes in acute promyelocytic leukemia.","12970771","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","22056878",2012,"Synergistic antitumor activity of lapatinib and retinoids on a novel subtype of breast cancer with coamplification of ERBB2 and RARA.","22056878","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","12935977",2003,"All-trans retinoic acid modulates microvascular endothelial cell hemostatic properties.","12935977","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","12921748",2003,"Retinoid receptors and vitamin A deficiency: differential patterns of transcription during early avian development and the rapid induction of RARs by retinoic acid.","12921748","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","12805378",2003,"Activation of protein kinase C delta by all-trans-retinoic acid.","12805378","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","14970265",2004,"Tissue microarrays for hypothesis generation.","14970265","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","20876578",2010,"Synergistic effect of retinoic acid and cytokines on the regulation of glial fibrillary acidic protein expression.","20876578","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","20945395",2011,"Retinoic acid receptor-mediated signaling protects cardiomyocytes from hyperglycemia induced apoptosis: role of the renin-angiotensin system.","20945395","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","20945414",2011,"Inhibition of all-trans-retinoic acid-induced proteasome activation potentiates the differentiating effect of retinoid in acute myeloid leukemia cells.","20945414","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","20952403",2011,"Chromatin and DNA methylation dynamics during retinoic acid-induced RET gene transcriptional activation in neuroblastoma cells.","20952403","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","15080786",2004,"Human thyroid carcinoma cell lines show different retinoic acid receptor repertoires and retinoid responses.","15080786","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","21099229",2011,"A role for all-trans-retinoic acid in the early steps of lymphatic vasculature development.","21099229","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","21152046",2010,"The \"Phantom Effect\" of the Rexinoid LG100754: structural and functional insights.","21152046","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","21159962",2010,"Fragile X protein FMRP is required for homeostatic plasticity and regulation of synaptic strength by retinoic acid.","21159962","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","12591602",2003,"The role of a retinoic acid response element in establishing the anterior neural expression border of Hoxd4 transgenes.","12591602","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","21419664",2011,"Essential role for retinoic acid in the promotion of CD4(+) T cell effector responses via retinoic acid receptor alpha.","21419664","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","12615055",2003,"Combined RAR alpha- and RXR-specific ligands overcome N-myc-associated retinoid resistance in neuroblastoma cells.","12615055","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","14715249",2004,"Insulin-like growth factor binding protein-3 prevents retinoid receptor heterodimerization: implications for retinoic acid-sensitivity in human breast cancer cells.","14715249","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","12640113",2003,"Retinoic acid repression of bone morphogenetic protein 4 in inner ear development.","12640113","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","12646247",2003,"CBP/p300 induction is required for retinoic acid sensitivity in human mammary cells.","12646247","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","22585464",2012,"Retinoic acid alleviates Con A-induced hepatitis and differentially regulates effector production in NKT cells.","22585464","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","21281018",2011,"Agathisflavone enhances retinoic acid-induced neurogenesis and its receptors ? and ? in pluripotent stem cells.","21281018","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","14960275",2004,"Regulation of segmental patterning by retinoic acid signaling during Xenopus somitogenesis.","14960275","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","14959844",2003,"Cross-talk between retinoic acid and STAT3 signaling pathways in acute promyelocytic leukemia.","14959844","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","21310893",2011,"Retinoic acid inhibits endometrial cancer cell growth via multiple genomic mechanisms.","21310893","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","22485251",2012,"All-trans retinoic acid inhibits tumor growth of human osteosarcoma             by activating Smad signaling-induced osteogenic differentiation.","22485251","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","14725900",2004,"All-trans retinoic acid directly up-regulates thrombopoietin transcription in human bone marrow stromal cells.","14725900","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","12423680",2002,"The catalytic DNA topoisomerase II inhibitor ICRF-193 and all-trans retinoic acid cooperatively induce granulocytic differentiation of acute promyelocytic leukemia cells: candidate drugs for chemo-differentiation therapy against acute promyelocytic leukemia.","12423680","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","21237205",2011,"All-trans retinoic acid induces TLR-5 expression and cell differentiation and promotes flagellin-mediated cell functions in human THP-1 cells.","21237205","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","23571271",2013,"Nuclear factor of activated T-cells 1 increases sensitivity of v-myb transformed monoblasts to all-trans retinoic acid.","23571271","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","12032336",2002,"Variant-type PML-RAR(alpha) fusion transcript in acute promyelocytic leukemia: use of a cryptic coding sequence from intron 2 of the RAR(alpha) gene and identification of a new clinical subtype resistant to retinoic acid therapy.","12032336","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","19661293",2009,"Loss of anti-proliferative effect of all-trans retinoic acid in advanced stage of breast carcinogenesis.","19661293","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","23460729",2013,"BATF is required for normal expression of gut-homing receptors by T helper cells in response to retinoic acid.","23460729","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","15646024",2004,"Retinoic acid administration and vitamin A status modulate retinoid X receptor alpha and retinoic acid receptor alpha levels in mouse brown adipose tissue.","15646024","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","12009305",2002,"Anticancer effect of retinoic acid via AP-1 activity repression is mediated by retinoic acid receptor alpha and beta in gastric cancer cells.","12009305","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","15657432",2005,"c-Jun N-terminal kinase contributes to aberrant retinoid signaling in lung cancer cells by phosphorylating and inducing proteasomal degradation of retinoic acid receptor alpha.","15657432","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","11994980",2002,"all-trans-Retinoic acid-induced expression and regulation of retinoic acid 4-hydroxylase (CYP26) in human promyelocytic leukemia.","11994980","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","15667548",2005,"The co-expression of PML/RAR alpha and AML1/ETO fusion genes is associated with ATRA resistance.","15667548","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","23509325",2013,"Uncoupling RARA transcriptional activation and degradation clarifies the bases for APL response to therapies.","23509325","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","19524134",2009,"Re-differentiation of thyroid carcinoma cell lines treated with 5-Aza-2'-deoxycytidine and retinoic acid.","19524134","Tretinoin","retinoic acid receptor alpha"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L1988,L1988)","v":"Tretinoin"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M1988,M1988)","v":"retinoic acid receptor alpha"},1,0,1,0,"RARA",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K1988,K1988)","v":"23518351"},2013,"The histone demethylase PHF8 governs retinoic acid response in acute promyelocytic leukemia.","23518351","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","12069693",2002,"Androgen and retinoic acid interaction in LNCaP cells, effects on cell proliferation and expression of retinoic acid receptors and epidermal growth factor receptor.","12069693","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","19477911",2009,"All-trans retinoic acid down-regulates inflammatory responses by shifting the Treg/Th17 profile in human ulcerative and murine colitis.","19477911","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","19557639",2009,"Function of retinoid acid receptor alpha and p21 in all-trans-retinoic acid-induced acute T-lymphoblastic leukemia apoptosis.","19557639","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","23584676",2013,"Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives.","23584676","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","19468269",2009,"Differentiation therapy of acute myeloid leukemia: past, present and future.","19468269","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","19458357",2009,"RARalpha2 expression is associated with disease progression and plays a crucial role in efficacy of ATRA treatment in myeloma.","19458357","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","23613978",2013,"Csn3 gene is regulated by all-trans retinoic acid during neural differentiation in mouse P19 cells.","23613978","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","19450544",2009,"The ATRA-dependent overexpression of the glutamate transporter EAAC1 requires RARbeta induction.","19450544","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","19401466",2009,"Retinoic acid activates monoamine oxidase B promoter in human neuronal cells.","19401466","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","11819850",2001,"The effect pathway of retinoic acid through regulation of retinoic acid receptor alpha in gastric cancer cells.","11819850","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","15778294",2005,"Sonic hedgehog and retinoic acid synergistically promote sensory fate specification from bone marrow-derived pluripotent stem cells.","15778294","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,1,"RARA","15799023",2005,"Transforming growth factor-beta1 signaling participates in the physiological and pathological regulation of mouse inner ear development by all-trans retinoic acid.","15799023","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","19398580",2009,"ZNF536, a novel zinc finger protein specifically expressed in the brain, negatively regulates neuron differentiation by repressing retinoic acid-induced gene transcription.","19398580","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","11788605",2002,"Up-regulation of acid sphingomyelinase during retinoic acid-induced myeloid differentiation of NB4, a human acute promyelocytic leukemia cell line.","11788605","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","11784112",2002,"Posteriorization by FGF, Wnt, and retinoic acid is required for neural crest induction.","11784112","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","19490107",2009,"The endogenous retinoid metabolite S-4-oxo-9-cis-13,14-dihydro-retinoic acid activates retinoic acid receptor signalling both in vitro and in vivo.","19490107","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","12070176",2002,"Activation of retinoic acid receptor-dependent transcription by all-trans-retinoic acid metabolites and isomers.","12070176","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","19377461",2009,"GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis.","19377461","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","23529927",2013,"A critical role for the retinoic acid signaling pathway in the pathophysiology of gastrointestinal graft-versus-host disease.","23529927","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","9238678",1996,"Retinoic acid suppresses in-vitro decidualization of human endometrial stromal cells.","9238678","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","9657734",1998,"Mutations in the E-domain of RAR portion of the PML/RAR chimeric gene may confer clinical resistance to all-trans retinoic acid in acute promyelocytic leukemia.","9657734","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","9457077",1998,"Retinoic acid differentially regulates retinoic acid receptor-mediated pathways in the Hep3B cell line.","9457077","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","9209396",1997,"Unravelling of physiological functions of retinoic acid using a dominant-negative retinoic acid receptor.","9209396","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","9628876",1998,"Two distinct nuclear receptor interaction domains in NSD1, a novel SET protein that exhibits characteristics of both corepressors and coactivators.","9628876","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","9067579",1997,"Alterations of differentiation, clonal proliferation, cell cycle progression and bcl-2 expression in RAR alpha-altered sublines of HL-60.","9067579","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","9218465",1997,"Mutational analysis reveals that all-trans-retinoic acid, 9-cis-retinoic acid, and antagonist interact with distinct binding determinants of RARalpha.","9218465","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","9247151",1997,"9,13-di-cis-Retinoic acid induces the production of tPA and activation of latent TGF-beta via RAR alpha in a human liver stellate cell line, LI90.","9247151","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","7644503",1995,"Reexpression of retinoic acid receptor (RAR) gamma or overexpression of RAR alpha or RAR beta in RAR gamma-null F9 cells reveals a partial functional redundancy between the three RAR types.","7644503","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","9610863",1998,"Melanoma cell growth inhibition and melanocortin receptor downregulation induced by selective and non-selective retinoids.","9610863","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","9016759",1997,"Possible involvement of Bcl-2 pathway in retinoid X receptor alpha-induced apoptosis of HL-60 cells.","9016759","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","7639724",1995,"Characterization of nuclear retinoic acid binding activity in sensitive leukemic cell lines: cell specific uptake of ATRA and RAR alpha protein modulation.","7639724","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","7672716",1995,"Molecular monitoring of minimal residual disease in acute promyelocytic leukemia by the polymerase chain reaction assay for the PML/RAR alpha (retinoic acid receptor-alpha) fusion transcript in patients treated with all-trans retinoic acid followed by chemotherapy.","7672716","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","7529139",1995,"Promyelocytic leukemia-specific PML-retinoic acid alpha receptor fusion protein interferes with erythroid differentiation of human erythroleukemia K562 cells.","7529139","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","7657595",1995,"Mutagenesis of the ligand binding domain of the human retinoic acid receptor alpha identifies critical residues for 9-cis-retinoic acid binding.","7657595","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","9609098",1998,"Tumor suppressor function of a dominant negative retinoic acid receptor mutant.","9609098","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","9462740",1998,"Distinct interactions of PML-RARalpha and PLZF-RARalpha with co-repressors determine differential responses to RA in APL.","9462740","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","9616182",1998,"Secondary leukemia responsive to retinoic acid with abnormal localization of RARalpha protein: a report of two cases.","9616182","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","9450572",1998,"Arsenic trioxide as an inducer of apoptosis and loss of PML/RAR alpha protein in acute promyelocytic leukemia cells.","9450572","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","9053313",1997,"An essential role for retinoid signaling in anteroposterior neural patterning.","9053313","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","9234742",1997,"Opposite effects of the acute promyelocytic leukemia PML-retinoic acid receptor alpha (RAR alpha) and PLZF-RAR alpha fusion proteins on retinoic acid signalling.","9234742","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","9342185",1997,"Retinoid-mediated inhibition of cell growth with stimulation of apoptosis in aggressive B-cell lymphomas.","9342185","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","9342843",1997,"Common defects of different retinoic acid resistant promyelocytic leukemia cells are persistent telomerase activity and nuclear body disorganization.","9342843","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","9284950",1997,"Retinoic acid induced growth arrest of human breast carcinoma cells requires protein kinase C alpha expression and activity.","9284950","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","9122185",1997,"Coexpression of nuclear receptor partners increases their solubility and biological activities.","9122185","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","9345016",1997,"Induction of apoptosis without differentiation by retinoic acid in PLB-985 cells requires the activation of both RAR and RXR.","9345016","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","9351827",1997,"Phosphorylation of activation functions AF-1 and AF-2 of RAR alpha and RAR gamma is indispensable for differentiation of F9 cells upon retinoic acid and cAMP treatment.","9351827","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","7579425",1995,"On the differentiative mode of action of All-trans retinoic acid in acute promyelocytic leukemia.","7579425","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","7581005",1995,"Study of retinoic acid effect upon retinoic acid receptors beta (RAR-beta) in C6 cultured glioma cells.","7581005","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","9436034",1997,"[Retinoic acid-induced cell growth inhibition and differentiation in testicular carcinoma cells in culture].","9436034","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","9361184",1997,"1 alpha,25-dihydroxyvitamin D3 receptor as a mediator of transrepression of retinoid signaling.","9361184","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","9160665",1997,"Involvement of retinoic acid receptor-alpha-mediated signaling pathway in induction of CD38 cell-surface antigen.","9160665","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","9450562",1998,"Arsenic and apoptosis in the treatment of acute promyelocytic leukemia.","9450562","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,1,"RARA","9417874",1997,"Reduction of both RAR and RXR levels is required to maximally alter sensitivity of CA-OV3 ovarian tumor cells to growth suppression by all-trans-retinoic acid.","9417874","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","9516856",1997,"Retinoids in neuroblastoma therapy: distinct biological properties of 9-cis- and all-trans-retinoic acid.","9516856","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","9377552",1997,"Expression of a dominant-negative retinoic acid receptor construct reduces retinoic acid metabolism and retinoic acid-induced inhibition of NIH-3T3 cell growth.","9377552","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","9113387",1997,"All-trans retinoic acid inhibits dexamethasone-induced ALP activity and mineralization in human osteoblastic cell line SV HFO.","9113387","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","9759370",1998,"[Arsenic and retinoic acid, toward targeted treatments of acute promyelocytic anemia?].","9759370","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","9426202",1997,"Retinoic acid and arsenic: towards oncogene-targeted treatments of acute promyelocytic leukaemia.","9426202","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","9153223",1997,"All-trans-retinoic acid increases transforming growth factor-beta2 and insulin-like growth factor binding protein-3 expression through a retinoic acid receptor-alpha-dependent signaling pathway.","9153223","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,1,"RARA","9377582",1997,"Induction of retinoid resistance in breast cancer cells by overexpression of cJun.","9377582","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","9560303",1998,"Inhibition of activation-induced apoptosis of thymocytes by all-trans- and 9-cis-retinoic acid is mediated via retinoic acid receptor alpha.","9560303","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","8530418",1995,"Multiple functions of the TR2-11 orphan receptor in modulating activation of two key cis-acting elements involved in the retinoic acid signal transduction system.","8530418","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","9387294",1996,"[Growth inhibitory effect of retinoic acid in human breast cancer cells correlates with retinoic acid receptor alpha (RAR alpha) expression].","9387294","Tretinoin","retinoic acid receptor alpha"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L2052,L2052)","v":"Tretinoin"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M2052,M2052)","v":"retinoic acid receptor alpha"},1,0,1,0,"RARA",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K2052,K2052)","v":"9369431"},1997,"Mutant AF-2 domain of PML-RARalpha in retinoic acid-resistant NB4 cells: differentiation induced by RA is triggered directly through PML-RARalpha and its down-regulation in acute promyelocytic leukemia.","9369431","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","9115966",1997,"Isochromosome for derivative 17q in acute promyelocytic leukemia: evidence for two copies of PML-RARA and favorable response to all-trans-retinoic acid therapy.","9115966","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","8649786",1996,"Differential changes of retinoid-X-receptor (RXR alpha) and its RAR alpha and PML-RAR alpha partners induced by retinoic acid and cAMP distinguish maturation sensitive and resistant t(15;17) promyelocytic leukemia NB4 cells.","8649786","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","8637250",1996,"RT-PCR in acute promyelocytic leukemia: second workshop of the European Retinoic Group, Paris, France, 17-18 December 1994.","8637250","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","8637715",1996,"Overexpression of both RAR and RXR restores AP-1 repression in ovarian adenocarcinoma cells resistant to retinoic acid-dependent growth inhibition.","8637715","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","8017844",1994,"Regulation of retinoic acid receptor alpha expression in human neuroblastoma cell lines and tumor tissue.","8017844","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","8639801",1996,"Infrequent alterations of the RAR alpha gene in acute myelogenous leukemias, retinoic acid-resistant acute promyelocytic leukemias, myelodysplastic syndromes, and cell lines.","8639801","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","7994028",1994,"Retinoids (all-trans and 9-cis retinoic acid) stimulate production of macrophage colony-stimulating factor and granulocyte-macrophage colony-stimulating factor by human bone marrow stromal cells.","7994028","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","8640761",1996,"Comparison of N-(4-hydroxyphenyl)retinamide and all-trans-retinoic acid in the regulation of retinoid receptor-mediated gene expression in human breast cancer cell lines.","8640761","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","7918086",1994,"Marked basophilia in acute promyelocytic leukaemia treated with all-trans retinoic acid: molecular analysis of the cell origin of the basophils.","7918086","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","8645577",1996,"Growth-inhibitory effects of vitamin D analogues and retinoids on human pancreatic cancer cells.","8645577","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","8634447",1996,"Effects of novel retinoid X receptor-selective ligands on myeloid leukemia differentiation and proliferation in vitro.","8634447","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","7957103",1994,"Activation function 2 (AF-2) of retinoic acid receptor and 9-cis retinoic acid receptor: presence of a conserved autonomous constitutive activating domain and influence of the nature of the response element on AF-2 activity.","7957103","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","8649787",1996,"cAMP signalling is decisive for recovery of nuclear bodies (PODs) during maturation of RA-resistant t(15;17) promyelocytic leukemia NB4 cells expressing PML-RAR alpha.","8649787","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","7950981",1994,"Characterization of human retinoic acid receptor alpha 1 expressed in recombinant baculovirus-infected Sf9 insect cells.","7950981","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","7706222",1994,"Repression of retinoic acid-induced transactivation by embryonal LTR binding protein.","7706222","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","8674046",1996,"Accelerated degradation of PML-retinoic acid receptor alpha (PML-RARA) oncoprotein by all-trans-retinoic acid in acute promyelocytic leukemia: possible role of the proteasome pathway.","8674046","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","7934625",1994,"The prevention of adipose differentiation of 3T3-L1 cells caused by retinoic acid is elicited through retinoic acid receptor alpha.","7934625","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","8641047",1995,"Two isoforms of Xenopus retinoic acid receptor gamma 2 (B) exhibit differential expression and sensitivity to retinoic acid during embryogenesis.","8641047","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","8597899",1996,"Differentiation therapy of acute promyelocytic leukemia: clinical and molecular features.","8597899","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","8290265",1994,"The PML-RAR alpha gene product of the t(15;17) translocation inhibits retinoic acid-induced granulocytic differentiation and mediated transactivation in human myeloid cells.","8290265","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","8289472",1994,"Rapid achievement of PML-RAR alpha polymerase chain reaction (PCR)-negativity by combined treatment with all-trans-retinoic acid and chemotherapy in acute promyelocytic leukemia: a pilot study.","8289472","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","8268249",1993,"Hydrodynamic characterization and DNA-binding properties of the liganded and unliganded forms of the retinoic-acid receptor alpha from human HL-60 cells.","8268249","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","9888461",1999,"Transcriptional repression of the human collagenase-1 (MMP-1) gene in MDA231 breast cancer cells by all-trans-retinoic acid requires distal regions of the promoter.","9888461","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","8524212",1995,"Synergistic activation of retinoic acid (RA)-responsive genes and induction of embryonal carcinoma cell differentiation by an RA receptor alpha (RAR alpha)-, RAR beta-, or RAR gamma-selective ligand in combination with a retinoid X receptor-specific ligand.","8524212","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","8544175",1995,"Synthesis, structure-affinity relationships, and biological activities of ligands binding to retinoic acid receptor subtypes.","8544175","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","8080665",1994,"PML/RAR alpha + ATRA = CR. A comment on acute promyelocytic leukaemia: molecular pathology and treatment.","8080665","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","8584029",1995,"Retinoic acid regulates the expression of the calcium binding protein, calbindin-D28K.","8584029","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","8635515",1996,"Dominant negative mutant of retinoic acid receptor alpha inhibits retinoic acid-induced P19 cell differentiation by binding to DNA.","8635515","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","8601401",1996,"An analysis of the effects of retinoic acid and other retinoids on the development of adrenergic cells from the avian neural crest.","8601401","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","8144129",1994,"Detection of minimal residual disease in a patient with acute promyelocytic leukemia by RT-PCR: necessity of chemotherapy following ATRA therapy.","8144129","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","8619133",1995,"Gene expression in response to retinoic acid in novel human chromosome 21 monochromosomal cell hybrids.","8619133","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","8139538",1994,"Distinct binding determinants for 9-cis retinoic acid are located within AF-2 of retinoic acid receptor alpha.","8139538","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","8619960",1995,"Modulation of limb bud chondrogenesis by retinoic acid and retinoic acid receptors.","8619960","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","8626453",1996,"Retinoic acid down-regulation of fibronectin and retinoic acid receptor alpha proteins in NIH-3T3 cells. Blocks of this response by ras transformation.","8626453","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,1,"RARA","7949141",1994,"Early mortality and the retinoic acid syndrome in acute promyelocytic leukemia: impact of leukocytosis, low-dose chemotherapy, PMN/RAR-alpha isoform, and CD13 expression in patients treated with all-trans retinoic acid.","7949141","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","9879990",1998,"Critical role of both retinoid nuclear receptors and retinoid-X-receptors in mediating growth inhibition of ovarian cancer cells by all-trans retinoic acid.","9879990","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","7823950",1995,"Targeted disruption of retinoic acid receptor alpha (RAR alpha) and RAR gamma results in receptor-specific alterations in retinoic acid-mediated differentiation and retinoic acid metabolism.","7823950","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","9700083",1998,"Retinoic acid-receptor activation of SP-B gene transcription in respiratory epithelial cells.","9700083","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","9715277",1998,"Favorable prognostic significance of high-level retinoic acid receptor beta expression in neuroblastoma mediated by effects on cell cycle regulation.","9715277","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","7727406",1995,"Structural determinants of the ligand-binding site of the human retinoic acid receptor alpha.","7727406","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","8947586",1996,"Mutation in the ligand-binding domain of the retinoic acid receptor alpha in HL-60 leukemic cells resistant to retinoic acid and with increased sensitivity to vitamin D3 analogs.","8947586","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","8902802",1996,"Retinoid-dependent in vitro transcription.","8902802","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","8670216",1996,"Retinoic acid differentially up-regulates the gene expression of retinoic acid receptor alpha and gamma isoforms in embryo and adult rats.","8670216","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","9679985",1998,"Retinoic acid induced mitogen-activated protein (MAP)/extracellular signal-regulated kinase (ERK) kinase-dependent MAP kinase activation needed to elicit HL-60 cell differentiation and growth arrest.","9679985","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","8695801",1996,"Stimulation of tissue-type plasminogen activator expression by retinoic acid in human endothelial cells requires retinoic acid receptor beta 2 induction.","8695801","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","7737367",1995,"Cellular aging and transformation suppression: a role for retinoic acid receptor beta 2.","7737367","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","9716180",1998,"Human retinoic acid (RA) 4-hydroxylase (CYP26) is highly specific for all-trans-RA and can be induced through RA receptors in human breast and colon carcinoma cells.","9716180","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,1,"RARA","9678691",1998,"Pseudotumor cerebri in a patient with acute promyelocytic leukemia during treatment with all-trans retinoic acid.","9678691","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","7719237",1995,"Acute promyelocytic leukaemia cells resistant to retinoic acid show further perturbation of the RAR alpha signal transduction system.","7719237","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","8816450",1996,"Analysis of the ligand-binding domain of human retinoic acid receptor alpha by site-directed mutagenesis.","8816450","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","7737364",1995,"Transcriptional modulation of the human intercellular adhesion molecule gene I (ICAM-1) by retinoic acid in melanoma cells.","7737364","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,1,"RARA","9673404",1998,"Antiproliferative activity and apoptosis induced by retinoic acid receptor-gamma selectively binding retinoids in neuroblastoma.","9673404","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","8702232",1996,"Biochemical characteristics and differentiating activity of 4-oxo analogs of retinoic acid.","8702232","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","7892182",1995,"The N-terminal portion of domain E of retinoic acid receptors alpha and beta is essential for the recognition of retinoic acid and various analogs.","7892182","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","7890689",1995,"A novel regulatory pathway of brown fat thermogenesis. Retinoic acid is a transcriptional activator of the mitochondrial uncoupling protein gene.","7890689","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","8702769",1996,"The AF-2 region of the retinoic acid receptor alpha mediates retinoic acid inhibition of estrogen receptor function in breast cancer cells.","8702769","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","8839844",1996,"E3, a hematopoietic-specific transcript directly regulated by the retinoic acid receptor alpha.","8839844","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","7706255",1995,"Retinoic acid induction of human tissue-type plasminogen activator gene expression via a direct repeat element (DR5) located at -7 kilobases.","7706255","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","9075714",1997,"Effect of retinoid status on the messenger ribonucleic acid expression of nuclear retinoid receptors alpha, beta, and gamma, and retinoid X receptors alpha, beta, and gamma in the mouse testis.","9075714","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","8752277",1996,"Two distinct actions of retinoid-receptor ligands.","8752277","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","8756459",1996,"Analysis of the effects of CRABP I expression on the RA-induced transcription mediated by retinoid receptors.","8756459","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","8758302",1996,"Differentiation therapy of acute promyelocytic leukemia.","8758302","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha",1,0,1,0,"RARA","8770910",1996,"Inhibitory effects of retinoic acids on androgen-dependent development of neonatal mouse seminal vesicles in vitro.","8770910","Tretinoin","retinoic acid receptor alpha"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L2116,L2116)","v":"Tretinoin"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M2116,M2116)","v":"retinoic acid receptor alpha"},1,0,1,0,"RARA",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K2116,K2116)","v":"8788040"},1996,"Receptor-selective retinoids implicate retinoic acid receptor alpha and gamma in the regulation of bmp-2 and bmp-4 in F9 embryonal carcinoma cells.","8788040","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","10869350",2000,"Dimerization with retinoid X receptors and phosphorylation modulate the retinoic acid-induced degradation of retinoic acid receptors alpha and gamma through the ubiquitin-proteasome pathway.","10869350","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,1,"RARG","12588859",2003,"Developing with lethal RA levels: genetic ablation of Rarg can restore the viability of mice lacking Cyp26a1.","12588859","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","10976925",2000,"Cytochrome P450RAI(CYP26) promoter: a distinct composite retinoic acid response element underlies the complex regulation of retinoic acid metabolism.","10976925","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","16007204",2005,"Synergistic induction of the MUC4 mucin gene by interferon-gamma and retinoic acid in human pancreatic tumour cells involves a reprogramming of signalling pathways.","16007204","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","17637747",2008,"Retinoic acid induces TGFbeta-dependent autocrine fibroblast growth.","17637747","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","11331070",2001,"Involvement of all-trans-retinoic acid in the breakdown of retinoic acid receptors alpha and gamma through proteasomes in MCF-7 human breast cancer cells.","11331070","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,1,"RARG","18703560",2008,"Retinoic acid receptor gamma-induced misregulation of chondrogenesis in the murine limb bud in vitro.","18703560","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","10699072",2000,"A ligand of peroxisome proliferator-activated receptor gamma, retinoids, and prevention of preneoplastic mammary lesions.","10699072","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","12504905",2003,"Arginine of retinoic acid receptor beta which coordinates with the carboxyl group of retinoic acid functions independent of the amino acid residues responsible for retinoic acid receptor subtype ligand specificity.","12504905","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","19179438",2009,"Retinoic acid reduces glucocorticoid sensitivity in C2C12 myotubes by decreasing 11beta-hydroxysteroid dehydrogenase type 1 and glucocorticoid receptor activities.","19179438","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","10660115",2000,"Differential effects of retinoic acid on growth and apoptosis in human colon cancer cell lines associated with the induction of retinoic acid receptor beta.","10660115","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","23264745",2013,"RAR? is essential for retinoic acid induced chromatin remodeling and transcriptional activation in embryonic stem cells.","23264745","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","18164278",2008,"Gene expression profiling elucidates a specific role for RARgamma in the retinoic acid-induced differentiation of F9 teratocarcinoma stem cells.","18164278","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","11340568",2001,"Expression of retinoic acid receptor gamma correlates with retinoic acid sensitivity and metabolism in head and neck squamous cell carcinoma cell lines.","11340568","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","10785230",2000,"Retinoic acid suppresses interleukin-6 production in human endometrial cells.","10785230","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","16341128",2006,"Overexpression of RARgamma increases death of SH-SY5Y neuroblastoma cells in response to retinoic acid but not fenretinide.","16341128","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","11778229",2000,"[Mechanism of retinoic acid receptor alpha-mediated growth inhibition of gastric cancer cells by all-trans retinoic acid].","11778229","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","10896783",2000,"Retinoic acid-mediated G1 arrest is associated with induction of p27(Kip1) and inhibition of cyclin-dependent kinase 3 in human lung squamous carcinoma CH27 cells.","10896783","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","15161940",2004,"Non-genomic regulation of transmitter release by retinoic acid at developing motoneurons in Xenopus cell culture.","15161940","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","11526081",2001,"Local retinoid signaling coordinates forebrain and facial morphogenesis by maintaining FGF8 and SHH.","11526081","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","18715802",2009,"Regulation of CD8(+) T cell functions by RARgamma.","18715802","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","20410309",2010,"Transcriptional regulation of cannabinoid receptor-1 expression in the liver by retinoic acid acting via retinoic acid receptor-gamma.","20410309","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","10910773",2000,"The conserved amphipatic alpha-helical core motif of RARgamma and RARalpha activating domains is indispensable for RA-induced differentiation of F9 cells.","10910773","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","10075839",1999,"Essential roles of retinoic acid signaling in interdigital apoptosis and control of BMP-7 expression in mouse autopods.","10075839","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","19524134",2009,"Re-differentiation of thyroid carcinoma cell lines treated with 5-Aza-2'-deoxycytidine and retinoic acid.","19524134","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","11855864",2002,"Retinoid signaling is attenuated by proteasome-mediated degradation of retinoid receptors in human keratinocyte HaCaT cells.","11855864","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","10933889",2000,"Role of Ser(289) in RARgamma and its homologous amino acid residue of RARalpha and RARbeta in the binding of retinoic acid.","10933889","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","11494305",2001,"Effects of retinoids and thiazolidinediones on proliferation, insulin release, insulin mRNA, GLUT 2 transporter protein and mRNA of INS-1 cells.","11494305","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","11493540",2001,"Hindbrain patterning involves graded responses to retinoic acid signalling.","11493540","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","17785809",2007,"Vitamin A metabolites induce gut-homing FoxP3+ regulatory T cells.","17785809","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","10075925",1999,"Identification of heparin-binding EGF-like growth factor as a target in intercellular regulation of epidermal basal cell growth by suprabasal retinoic acid receptors.","10075925","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","12070176",2002,"Activation of retinoic acid receptor-dependent transcription by all-trans-retinoic acid metabolites and isomers.","12070176","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","17943189",2008,"Retinoic acid increases aquaporin 3 expression in normal human skin.","17943189","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","12186877",2002,"Transcriptional induction of mitogen-activated protein kinase phosphatase 1 by retinoids. Selective roles of nuclear receptors and contribution to the antiapoptotic effect.","12186877","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","17291686",2007,"Expression, protein stability and transcriptional activity of retinoic acid receptors are affected by microtubules interfering agents and all-trans-retinoic acid in primary rat hepatocytes.","17291686","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","12668623",2003,"Retinoic acid-induced developmental defects are mediated by RARbeta/RXR heterodimers in the pharyngeal endoderm.","12668623","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","21807577",2011,"Retinoic acid drives aryl hydrocarbon receptor expression and is instrumental to dioxin-induced toxicity during palate development.","21807577","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","20043900",2010,"Analysis of Cyp26b1/Rarg compound-null mice reveals two genetically separable effects of retinoic acid on limb outgrowth.","20043900","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","11161715",2001,"Retinoid X receptor alpha and retinoic acid receptor gamma mediate expression of genes encoding tight-junction proteins and barrier function in F9 cells during visceral endodermal differentiation.","11161715","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","12189556",2002,"Retinoids cause apoptosis in pancreatic cancer cells via activation of RAR-gamma and altered expression of Bcl-2/Bax.","12189556","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","19661293",2009,"Loss of anti-proliferative effect of all-trans retinoic acid in advanced stage of breast carcinogenesis.","19661293","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","12921748",2003,"Retinoid receptors and vitamin A deficiency: differential patterns of transcription during early avian development and the rapid induction of RARs by retinoic acid.","12921748","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","15867260",2005,"Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.","15867260","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","21826789",2011,"Retinoic acid modulates chondrogenesis in the developing mouse cranial base.","21826789","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","10344761",1999,"Expression and up-regulation of retinoic acid receptor-beta is associated with retinoid sensitivity and colony formation in esophageal cancer cell lines.","10344761","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","19683536",2009,"Cell cycle regulatory effects of retinoic Acid and forskolin are mediated by the cyclin C gene.","19683536","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","12069693",2002,"Androgen and retinoic acid interaction in LNCaP cells, effects on cell proliferation and expression of retinoic acid receptors and epidermal growth factor receptor.","12069693","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","11212249",2001,"Increased retinoic acid responsiveness in lung carcinoma cells that are nonresponsive despite the presence of endogenous retinoic acid receptor (RAR) beta by expression of exogenous retinoid receptors retinoid X receptor alpha, RAR alpha, and RAR gamma.","11212249","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","21988834",2011,"Dissecting the retinoid-induced differentiation of F9 embryonal stem cells by integrative genomics.","21988834","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","16038797",2005,"Phosphorylation of the retinoid x receptor at the omega loop, modulates the expression of retinoic-acid-target genes with a promoter context specificity.","16038797","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","22396202",2012,"Retinoic acid upregulates preadipocyte genes to block adipogenesis and suppress diet-induced obesity.","22396202","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","16788091",2006,"Antitumor activity of the retinoid-related molecules (E)-3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid (ST1926) and 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437) in F9 teratocarcinoma: Role of retinoic acid receptor gamma and retinoid-independent pathways.","16788091","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","22405964",2012,"Median facial clefts in Xenopus laevis: roles of retinoic acid signaling and homeobox genes.","22405964","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","12671705",2003,"Tyrosine-kinase expression profiles in human gastric cancer cell lines and their modulations with retinoic acids.","12671705","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","12110588",2002,"Phosphorylation by p38MAPK and recruitment of SUG-1 are required for RA-induced RAR gamma degradation and transactivation.","12110588","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","12032135",2002,"Down-regulation of the phosphatidylinositol 3-kinase/Akt pathway is involved in retinoic acid-induced phosphorylation, degradation, and transcriptional activity of retinoic acid receptor gamma 2.","12032135","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","14614773",2003,"Bovine cumulus-granulosa cells contain biologically active retinoid receptors that can respond to retinoic acid.","14614773","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","18539269",2008,"Impairing retinoic acid signalling in the neural crest cells is sufficient to alter entire eye morphogenesis.","18539269","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","19279407",2009,"Mechanisms underlying the induction of the putative human tumor suppressor GPRC5A by retinoic acid.","19279407","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","11819850",2001,"The effect pathway of retinoic acid through regulation of retinoic acid receptor alpha in gastric cancer cells.","11819850","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","17363914",2007,"Immunolocalization of enzymes, binding proteins, and receptors sufficient for retinoic acid synthesis and signaling during the hair cycle.","17363914","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","11751425",2001,"Overexpression of retinoic acid receptors alpha and gamma into neoplastic epidermal cells causes retinoic acid-induced growth arrest and apoptosis.","11751425","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","11032179",2000,"Stage-dependent responses of the developing lung to retinoic acid signaling.","11032179","Tretinoin","retinoic acid receptor gamma"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L2180,L2180)","v":"Tretinoin"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M2180,M2180)","v":"retinoic acid receptor gamma"},1,0,1,0,"RARG",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K2180,K2180)","v":"9442090"},1998,"Mouse P450RAI (CYP26) expression and retinoic acid-inducible retinoic acid metabolism in F9 cells are regulated by retinoic acid receptor gamma and retinoid X receptor alpha.","9442090","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","9888461",1999,"Transcriptional repression of the human collagenase-1 (MMP-1) gene in MDA231 breast cancer cells by all-trans-retinoic acid requires distal regions of the promoter.","9888461","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,1,"RARG","9673404",1998,"Antiproliferative activity and apoptosis induced by retinoic acid receptor-gamma selectively binding retinoids in neuroblastoma.","9673404","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","9879990",1998,"Critical role of both retinoid nuclear receptors and retinoid-X-receptors in mediating growth inhibition of ovarian cancer cells by all-trans retinoic acid.","9879990","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","9882496",1999,"A molecular basis for retinoic acid-induced axial truncation.","9882496","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","9700083",1998,"Retinoic acid-receptor activation of SP-B gene transcription in respiratory epithelial cells.","9700083","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","9715277",1998,"Favorable prognostic significance of high-level retinoic acid receptor beta expression in neuroblastoma mediated by effects on cell cycle regulation.","9715277","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","9716180",1998,"Human retinoic acid (RA) 4-hydroxylase (CYP26) is highly specific for all-trans-RA and can be induced through RA receptors in human breast and colon carcinoma cells.","9716180","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","9852056",1998,"Arg278, but not Lys229 or Lys236, plays an important role in the binding of retinoic acid by retinoic acid receptor gamma.","9852056","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","9610863",1998,"Melanoma cell growth inhibition and melanocortin receptor downregulation induced by selective and non-selective retinoids.","9610863","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","9457077",1998,"Retinoic acid differentially regulates retinoic acid receptor-mediated pathways in the Hep3B cell line.","9457077","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","9501913",1998,"Conformational adaptation of agonists to the human nuclear receptor RAR gamma.","9501913","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","9787905",1998,"Surface-enhanced Raman scattering and fluorescence spectroscopy reveal molecular interactions of all-trans retinoic acid and RAR gamma ligand-binding domain.","9787905","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","9560303",1998,"Inhibition of activation-induced apoptosis of thymocytes by all-trans- and 9-cis-retinoic acid is mediated via retinoic acid receptor alpha.","9560303","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","9753500",1998,"Retinoic acid receptor gamma1 expression determines retinoid sensitivity in pancreatic carcinoma cells.","9753500","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","9613452",1998,"Effect of retinoic acid on morphological changes of human pancreatic cancer cells on collagen gels: a possible association with the metastatic potentials.","9613452","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","8640761",1996,"Comparison of N-(4-hydroxyphenyl)retinamide and all-trans-retinoic acid in the regulation of retinoid receptor-mediated gene expression in human breast cancer cell lines.","8640761","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","9113387",1997,"All-trans retinoic acid inhibits dexamethasone-induced ALP activity and mineralization in human osteoblastic cell line SV HFO.","9113387","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","9077477",1997,"All-trans-retinoic acid inhibition of Pro alpha1(I) collagen gene expression in fetal rat skin fibroblasts: identification of a retinoic acid response element in the Pro alpha1(I) collagen gene.","9077477","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","8635515",1996,"Dominant negative mutant of retinoic acid receptor alpha inhibits retinoic acid-induced P19 cell differentiation by binding to DNA.","8635515","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","9075714",1997,"Effect of retinoid status on the messenger ribonucleic acid expression of nuclear retinoid receptors alpha, beta, and gamma, and retinoid X receptors alpha, beta, and gamma in the mouse testis.","9075714","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","8950195",1996,"Retinoic acid affects the expression rate of the differentiation-related genes aryl hydrocarbon receptor, ARNT and keratin 4 in proliferative keratinocytes only.","8950195","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,1,"RARG","7631783",1995,"Marked resistance of RAR gamma-deficient mice to the toxic effects of retinoic acid.","7631783","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","8770910",1996,"Inhibitory effects of retinoic acids on androgen-dependent development of neonatal mouse seminal vesicles in vitro.","8770910","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","7644503",1995,"Reexpression of retinoic acid receptor (RAR) gamma or overexpression of RAR alpha or RAR beta in RAR gamma-null F9 cells reveals a partial functional redundancy between the three RAR types.","7644503","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","8625166",1995,"all-trans retinoic acid for treating germ cell tumors. In vitro activity and results of a phase II trial.","8625166","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","8971348",1996,"Effects of retinoic acid on Xenopus embryos.","8971348","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","7628539",1995,"Effect of cellular senescence and retinoic acid on the expression of cellular retinoic acid binding proteins in skin fibroblasts.","7628539","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","7708726",1995,"Identification of the porcine intestinal accessory factor that enables DNA sequence recognition by vitamin D receptor.","7708726","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","8670216",1996,"Retinoic acid differentially up-regulates the gene expression of retinoic acid receptor alpha and gamma isoforms in embryo and adult rats.","8670216","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","7720576",1995,"Genesis and prevention of spinal neural tube defects in the curly tail mutant mouse: involvement of retinoic acid and its nuclear receptors RAR-beta and RAR-gamma.","7720576","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","7727406",1995,"Structural determinants of the ligand-binding site of the human retinoic acid receptor alpha.","7727406","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","7737367",1995,"Cellular aging and transformation suppression: a role for retinoic acid receptor beta 2.","7737367","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","8816450",1996,"Analysis of the ligand-binding domain of human retinoic acid receptor alpha by site-directed mutagenesis.","8816450","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","8798483",1996,"Ligand-induced conformational changes in the human retinoic acid receptor detected using monoclonal antibodies.","8798483","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","7823950",1995,"Targeted disruption of retinoic acid receptor alpha (RAR alpha) and RAR gamma results in receptor-specific alterations in retinoic acid-mediated differentiation and retinoic acid metabolism.","7823950","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","8788040",1996,"Receptor-selective retinoids implicate retinoic acid receptor alpha and gamma in the regulation of bmp-2 and bmp-4 in F9 embryonal carcinoma cells.","8788040","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","9016769",1997,"Purification of the human RARgamma ligand-binding domain and crystallization of its complex with all-trans retinoic acid.","9016769","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","9351827",1997,"Phosphorylation of activation functions AF-1 and AF-2 of RAR alpha and RAR gamma is indispensable for differentiation of F9 cells upon retinoic acid and cAMP treatment.","9351827","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","8544175",1995,"Synthesis, structure-affinity relationships, and biological activities of ligands binding to retinoic acid receptor subtypes.","8544175","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","7501014",1995,"Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid.","7501014","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,1,"RARG","9142499",1997,"Contribution of retinoic acid receptor gamma to retinoid-induced craniofacial and axial defects.","9142499","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","8108126",1994,"Response and resistance to retinoic acid are mediated through the retinoic acid nuclear receptor gamma in human teratocarcinomas.","8108126","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","9160665",1997,"Involvement of retinoic acid receptor-alpha-mediated signaling pathway in induction of CD38 cell-surface antigen.","9160665","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","9242525",1997,"Treatment with a new synthetic retinoid, Am80, of acute promyelocytic leukemia relapsed from complete remission induced by all-trans retinoic acid.","9242525","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","9238678",1996,"Retinoic acid suppresses in-vitro decidualization of human endometrial stromal cells.","9238678","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","8619960",1995,"Modulation of limb bud chondrogenesis by retinoic acid and retinoic acid receptors.","8619960","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma",1,0,1,0,"RARG","9234742",1997,"Opposite effects of the acute promyelocytic leukemia PML-retinoic acid receptor alpha (RAR alpha) and PLZF-RAR alpha fusion proteins on retinoic acid signalling.","9234742","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","Nuclear Receptor Subfamily 1, Group F, Member 2",1,0,1,0,"RORB","12958591",2003,"All-trans retinoic acid is a ligand for the orphan nuclear receptor ROR beta.","12958591","Tretinoin","Nuclear Receptor Subfamily 1, Group F, Member 2"]
["Tretinoin","Nuclear Receptor Subfamily 1, Group F, Member 3",1,0,1,0,"RORC","22184266",2011,"Effect of all-trans retinoic acid (ATRA) on viability, proliferation, activation and lineage-specific transcription factors of CD4+ T cells.","22184266","Tretinoin","Nuclear Receptor Subfamily 1, Group F, Member 3"]
["Triamcinolone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","3366990",1988,"[In vitro binding of purified glucocorticoid- and estrogen-receptor complexes in the rat liver with homologous chromatin of different levels of molecular organization].","3366990","Triamcinolone","Receptors, Glucocorticoid"]
["Triamcinolone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","492173",1979,"Effects of glucocorticoids on fibroblasts.","492173","Triamcinolone","Receptors, Glucocorticoid"]
["Triamcinolone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","6111315",1981,"Glucocorticoid hormones are successively present in two sites with different accessibilities to nucleases in chromatin from HTC cells.","6111315","Triamcinolone","Receptors, Glucocorticoid"]
["Triamcinolone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8440759",1993,"Receptor-based pharmacokinetic-pharmacodynamic analysis of corticosteroids.","8440759","Triamcinolone","Receptors, Glucocorticoid"]
["Triamcinolone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","8097375",1993,"Glucocorticoid regulation of splanchnic glutamine, alanine, glutamate, ammonia, and glutathione fluxes.","8097375","Triamcinolone","Receptors, Glucocorticoid"]
["Triamcinolone","Receptors, Glucocorticoid",0,0,1,0,"NR3C1","7729519",1995,"Temporary loss of glucocorticoid receptor-mediated regulation of gene expression in heat-shocked cells.","7729519","Triamcinolone","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","3965455",1985,"Triamcinolone acetonide regulates glucocorticoid-receptor levels by decreasing the half-life of the activated nuclear-receptor form.","3965455","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","3751612",1986,"Distribution and daily fluctuation of the available glucocorticoid binding sites in different areas of the quail brain.","3751612","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","2743328",1989,"Comparison of in vivo activation of triamcinolone acetonide- and RU 38486-receptor complexes in the CEM-C7 and IM-9 human leukemic cell lines.","2743328","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","3790617",1987,"Microheterogeneity of agonist and antagonist glucocorticoid receptor complexes detected by isoelectric focusing and modifications induced by receptor activation.","3790617","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","1786826",1991,"[The effect of antibiotics on the function of type-II and -III glucocorticoid receptors].","1786826","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","487996",1979,"Heterogeneity of glucocorticoid binders: a unique and a classical dexamethasone-binding site in bovine tissues.","487996","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","3855256",1985,"Triamcinolone acetonide 21-oic acid methyl ester: a potent local antiinflammatory steroid without detectable systemic effects.","3855256","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","2184891",1990,"The transformed glucocorticoid receptor has a lower steroid-binding affinity than the nontransformed receptor.","2184891","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L2244,L2244)","v":"Triamcinolone Acetonide"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M2244,M2244)","v":"Receptors, Glucocorticoid"},0,0,0,0,"NR3C1",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K2244,K2244)","v":"1996987"},1991,"Hepatic glucocorticoid receptor behaves differently when its hormone binding site is occupied by agonist (triamcinolone acetonide) or antagonist (RU486) steroid ligands.","1996987","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,1,"NR3C1","18493890",2008,"Congenital anomalies induced by triamcinolone acetonide in murine embryos.","18493890","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","3871335",1985,"Binding of [3H]triamcinolone acetonide-receptor complexes to chromatin from the B-cell leukemia line, BCL1.","3871335","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","3919942",1985,"Suppression of DNA synthesis in NEL-M1 human melanoma cells by triamcinolone acetonide.","3919942","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","446377",1979,"The intracellular distribution of natural and synthetic glucocorticoids in the AtT-20 cell.","446377","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","3984662",1985,"Receptor-mediated glucocorticoid inhibition of cell proliferation in mouse growth cartilage in vitro.","3984662","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","19016360",2009,"Glucocorticoids enhance regeneration of murine olfactory epithelium.","19016360","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","2303427",1990,"Mechanism of action of a steroidal antiglucocorticoid in lymphoid cells.","2303427","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","2214763",1990,"Progestin binds to the glucocorticoid receptor and mediates antiglucocorticoid effect in rat adipose precursor cells.","2214763","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","402362",1977,"A low molecular weight inhibitor of steroid receptor activation.","402362","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","2919163",1989,"Binding of hormone accelerates the kinetics of glucocorticoid and progesterone receptor binding to DNA.","2919163","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","444568",1979,"Corticosterone binding in AtT-20 pituitary tumor cell cytosol: evidence for one class of binding site for both natural and synthetic glucocorticoids.","444568","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","502553",1979,"Characteristics of glucocorticoid binding to mouse liver cytosol.","502553","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","2894483",1988,"Ketoconazole inhibition and glucocorticoid action in the human lymphoblastic leukemia cell line CEM-C7.","2894483","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","3884052",1985,"[A factor which modifies the interaction of steroids with glucocorticoid receptors].","3884052","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","16029572",2005,"[An experimental study on the mechanism of therapy for hemangioma with glucocorticoid].","16029572","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","2737458",1989,"The corticosteroid receptor and the action of various steroids in rainbow trout fibroblasts.","2737458","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","3382699",1988,"In vitro activation of rat cardiac glucocorticoid antagonist- versus agonist-receptor complexes.","3382699","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","3360809",1988,"Identification of hormone-interacting amino acid residues within the steroid-binding domain of the glucocorticoid receptor in relation to other steroid hormone receptors.","3360809","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","1562546",1992,"Mutations in the \"zinc fingers\" or in the N-terminal region of the DNA binding domain of the human glucocorticosteroid receptor facilitate its salt-induced transformation, but do not modify hormone binding.","1562546","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","357045",1978,"Induction of cleft palates by triamcinolone acetonide: re-examination of the problem.","357045","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","16816341",2006,"Differential glucocorticoid effects on proliferation and invasion of human trophoblast cell lines.","16816341","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","10571962",1999,"Identification and characterization of glucocorticoid receptors in B16 mouse melanoma cells.","10571962","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","19005987",2008,"Glucocorticoid receptor polymorphisms and intraocular pressure response to intravitreal triamcinolone acetonide.","19005987","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","2178688",1990,"Modifications of rat liver glucocorticoid receptor by insulin-induced hypoglycemia.","2178688","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","3614365",1987,"Antiglucocorticosteroid effects suggest why steroid hormone is required for receptors to bind DNA in vivo but not in vitro.","3614365","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","3707724",1986,"[The receptor system for glucocorticoids in myocardial cells. New approaches to the studies of its regulation and function].","3707724","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","3707584",1986,"Evidence for differences in the steroid binding domains of the glucocorticoid receptor versus the idiotype antibody.","3707584","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","1737773",1992,"Evidence that the hormone-binding domain of the mouse glucocorticoid receptor directly represses DNA binding activity in a major portion of receptors that are \"misfolded\" after removal of hsp90.","1737773","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","3624134",1987,"Testosterone fails to prevent skeletal muscle atrophy from glucocorticoids.","3624134","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","23745583",2013,"Triamcinolone acetonide inhibits p38MAPK activation and neuronal apoptosis in early diabetic retinopathy.","23745583","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","2160080",1990,"Glucocorticoid receptor-dependent disruption of a specific nucleosome on the mouse mammary tumor virus promoter is prevented by sodium butyrate.","2160080","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","2563330",1989,"[Effects of psychotropic drugs of the phenothiazine series on matrix activity of thymocyte DNA and glucocorticoid receptor interactions].","2563330","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","3609019",1987,"Transformation in vitro and covalent modification with biotin of steroid-affinity-purified rat-liver glucocorticoid-hormone-receptor complex.","3609019","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","7834624",1995,"Modulator inhibits nuclear translocation of the glucocorticoid receptor and inhibits glucocorticoid-induced apoptosis in the human leukemic cell line CEM C-7.","7834624","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","8392705",1993,"The glucocorticoid receptor hormone binding domain mediates transcriptional activation in vitro in the absence of ligand.","8392705","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","8463306",1993,"Kinetics of glucocorticoid receptor phosphorylation in intact cells. Evidence for hormone-induced hyperphosphorylation after activation and recycling of hyperphosphorylated receptors.","8463306","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","6139129",1983,"[Stages of the interaction of steroid hormones with intranuclear acceptor sites of Morris hepatoma cells].","6139129","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","6284140",1982,"Regulation of nuclear uptake of \"activated\" receptor-glucocorticoid complex by pyrophosphate.","6284140","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","8703946",1996,"Coordinate regulation of glucocorticoid receptor and c-jun gene expression is cell type-specific and exhibits differential hormonal sensitivity for down- and up-regulation.","8703946","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","8061598",1994,"Binding of [3H]triamcinolone acetonide to glucocorticoid receptors in brain cytosol fractions of rats with intact adrenals.","8061598","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","6149638",1983,"3-Chloro-1,3,5-pregnatriene derivatives with glucocorticoid activity.","6149638","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","7873448",1995,"Hormone-induced hyperphosphorylation of specific phosphorylated sites in the mouse glucocorticoid receptor.","7873448","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","8166236",1994,"Mineralocorticoid and glucocorticoid receptor steroid binding and localization in colonic cells.","8166236","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","6239284",1984,"[Specific glucocorticoid receptors of human muscle cytosol].","6239284","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","875634",1977,"Evidence for a factor in liver cytosol which controls the competition between progesterone and triamcinolone acetonide for the glucocorticoid receptor.","875634","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","7176655",1982,"Pyridoxal 5-phosphate protection of trypsin cleavage site on the glucocorticoid receptor protein.","7176655","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","7719648",1995,"In vitro and in vivo thermal activation of steroid-receptor complexes from rats and ground squirrels (Spermophilus citellus).","7719648","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","6974862",1981,"[Effect of steroid hormones on DNA matrix activity and glucocorticoid-receptor interaction].","6974862","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","7109601",1982,"Dependence of rate constants of the glucocorticoid hormone-receptor interaction on steroid structure.","7109601","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","7457603",1981,"Glucocorticoid receptors in rat kidney cortical tubules enriched in proximal and distal segments.","7457603","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","7430694",1980,"Corticoids and human skin fibroblasts: intracellular specific binding in relation to growth inhibition.","7430694","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","6775927",1980,"Heterogenetiy of glucocorticoid binders: a high affinity triamcinolone acetonide binder in bovine serum.","6775927","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","7176653",1982,"Inhibition of nuclear uptake of glucocorticoid-receptor complex by aurintricarboxylic acid.","7176653","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","7583234",1995,"Distinction between binding of [3H]triamcinolone acetonide to a ligand binding domain on the glucocorticoid receptor complex in cytosol fractions of brain and liver from the rat with intact adrenals.","7583234","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","7326005",1981,"Glucocorticoid binding in the hen oviduct.","7326005","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","7181913",1982,"Three forms of macromolecular translocation inhibitor of the nuclear binding of \"activated\" receptor-glucocorticoid complex and their interaction with ATP.","7181913","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","7190095",1980,"Progesterone enhances glucocorticoid dissociation from the AtT-20 cell glucocorticoid receptor.","7190095","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","7232365",1981,"[Glucocorticoid receptor content in the cytoplasm of human peripheral leukocytes].","7232365","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","720288",1978,"Nuclear glucocorticoid binding in chronic lymphatic leukemia lymphocytes.","720288","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","7213396",1981,"Interaction of ATP with a macromolecular translocation inhibitor of the nuclear binding of \"activated\" receptor-glucocorticoid complex.","7213396","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,1,"NR3C1","7385055",1980,"A glucocorticoid receptor in fetal mouse: its relationship to cleft palate formation.","7385055","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","8956337",1996,"Pulmonary targeting of liposomal triamcinolone acetonide phosphate.","8956337","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,1,"NR3C1","6323876",1984,"Lithium inhibits the cytolytic glucocorticoid effect on S49 mouse lymphoma cells.","6323876","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
[{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & L2308,L2308)","v":"Triamcinolone Acetonide"},{"$f":"HYPERLINK(\"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?term=\" & M2308,M2308)","v":"Receptors, Glucocorticoid"},0,0,0,0,"NR3C1",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & K2308,K2308)","v":"7724475"},1995,"Assessment of glucocorticoid lung targeting by ex-vivo receptor binding studies in rats.","7724475","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","9712407",1998,"Dexamethasone and triamcinolone acetonide accumulation in mouse fibroblasts is differently modulated by the immunosuppressants cyclosporin A, FK506, rapamycin and their analogues, as well as by other P-glycoprotein ligands.","9712407","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","6514685",1984,"[Type II glucocorticoid receptors in tissues of adrenalectomized rats].","6514685","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","6527355",1984,"Kinetic deuterium isotope effects in glucocorticoid receptor activation.","6527355","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","6615928",1983,"[Kinetics of the development of the glucocorticoid effect on the thymus in adrenalectomized rats].","6615928","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","6323138",1984,"The relationship between glucocorticoid biopotency and receptor binding in the AtT-20 cell.","6323138","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","6618155",1983,"Intestinal triamcinolone acetonide receptors of the eel (Anguilla rostrata).","6618155","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","6688425",1983,"Glucocorticoid receptors and cortico-sensitivity in a human clonal monocytic cell line, CM-SM.","6688425","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","6690056",1984,"Stabilization of labile glucocorticoid-receptor complexes from acute nonlymphocytic leukemia cells by a factor from chronic lymphocytic leukemia cells.","6690056","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","9563078",1998,"Effect of dose and release rate on pulmonary targeting of liposomal triamcinolone acetonide phosphate.","9563078","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triamcinolone Acetonide","Receptors, Glucocorticoid",0,0,0,0,"NR3C1","6708537",1984,"Hydrodynamic and biochemical correlates of the activation of the glucocorticoid-receptor complex.","6708537","Triamcinolone Acetonide","Receptors, Glucocorticoid"]
["Triclosan","pregnane X receptor",0,0,1,0,"NR1I2","23899473",2013,"Evidence for triclosan-induced activation of human and rodent xenobiotic nuclear receptors.","23899473","Triclosan","pregnane X receptor"]
["Triclosan","pregnane X receptor",0,0,1,1,"NR1I2","19910387",2010,"Short-term exposure to triclosan decreases thyroxine in vivo via upregulation of hepatic catabolism in Young Long-Evans rats.","19910387","Triclosan","pregnane X receptor"]
["Triclosan","constitutive androstane receptor",0,0,1,0,"NR1I3","23899473",2013,"Evidence for triclosan-induced activation of human and rodent xenobiotic nuclear receptors.","23899473","Triclosan","constitutive androstane receptor"]
["Triclosan","PPAR alpha",0,0,1,0,"PPARA","20377306",2010,"Triclosan: a critical review of the experimental data and development of margins of safety for consumer products.","20377306","Triclosan","PPAR alpha"]
["triflumizol","PPAR gamma",0,0,1,1,"PPARG","23086663",2012,"Triflumizole is an obesogen in mice that acts through peroxisome proliferator activated receptor gamma (PPAR?).","23086663","triflumizol","PPAR gamma"]
["triflumizol","PPAR gamma",0,0,1,1,"PPARG","23211365",2012,"Potential obesogen identified: fungicide triflumizole is associated with increased adipogenesis in mice.","23211365","triflumizol","PPAR gamma"]
["vinclozolin","Receptors, Glucocorticoid",1,0,1,0,"NR3C1","16750840",2006,"Steroid receptor profiling of vinclozolin and its primary metabolites.","16750840","vinclozolin","Receptors, Glucocorticoid"]
["Zidovudine","PPAR gamma",1,1,0,0,"PPARG","18474584",2008,"Zidovudine impairs adipogenic differentiation through inhibition of clonal expansion.","18474584","Zidovudine","PPAR gamma"]