{"text_format":"1","workbook":"xlsx","n_sheets":2,"sheets":["Overview","Detail"],"not_rendered":{"charts":0,"images":0,"macros":1,"external_links":0,"defined_names":3,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900"}

{"sheet":"Overview","index":0,"n_rows":25891,"n_cols":10,"rows_kept":4500,"cut":true,"hidden":false,"merged":[],"bounds":{"rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0}}
["Overview - AOP ",null,null,{"$f":"(HYPERLINK(\"https://aopwiki.org/aops/136\",\"aop 136\"))","v":"aop 136"}]
["pH Induced Nasal Tumors"]
["MeSH Chemical Name (hyperlinked)","ChemName","chemuid","1_MIE","2_KE","3_KE","4_KE","5_KE","6_KE","7_AO"]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C4,B4)","v":"Formaldehyde"},"Formaldehyde","D005557",450,237,54,29,99,21,281]
["Nitric Oxide","Nitric Oxide","D009569",1188,301,917,164,2673,60,196]
["Dust","Dust","D004391",117,103,19,14,12,5,190]
["Mupirocin","Mupirocin","D016712",4,32,2,0,2,2,126]
["Histamine","Histamine","D006632",702,365,143,26,123,7,94]
["Carbon Dioxide","Carbon Dioxide","D002245",10120,70,106,13,75,19,71]
["Cocaine","Cocaine","D003042",195,167,48,0,114,14,61]
["Lidocaine","Lidocaine","D008012",697,111,49,2,112,2,61]
["Hyaluronic Acid","Hyaluronic Acid","D006820",500,144,797,65,285,10,60]
["Sodium Chloride","Sodium Chloride","D012965",2365,126,74,8,127,13,60]
["4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone","4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone","C016583",16,33,46,6,30,14,54]
["Epinephrine","Epinephrine","D004837",851,186,32,2,40,3,54]
["Diethylnitrosamine","Diethylnitrosamine","D004052",24,34,70,11,76,8,45]
["Fluorodeoxyglucose F18","Fluorodeoxyglucose F18","D019788",26,88,126,38,35,2,44]
["Ozone","Ozone","D010126",844,163,52,72,80,5,44]
["Aspirin","Aspirin","D001241",635,120,248,27,467,1,41]
["N'-nitrosonornicotine","N'-nitrosonornicotine","C008655",14,14,4,0,4,3,41]
["Water","Water","D014867",7130,63,231,4,117,20,39]
["Methicillin","Methicillin","D008712",62,14,2,0,0,3,37]
["Nicotine","Nicotine","D009538",392,89,330,66,328,6,37]
["Dimethylnitrosamine","Dimethylnitrosamine","D004128",86,47,16,2,37,8,32]
["Acetaldehyde","Acetaldehyde","D000079",202,43,43,14,55,18,29]
["Ammonia","Ammonia","D000641",2693,83,28,0,43,7,29]
["Budesonide","Budesonide","D019819",62,89,55,2,29,0,29]
["Ethanol","Ethanol","D000431",1690,433,474,38,1192,80,28]
["Phenylephrine","Phenylephrine","D010656",125,43,8,0,26,1,28]
["propylene oxide","propylene oxide","C009068",6,14,2,0,2,2,28]
["Smoke","Smoke","D012906",114,78,213,63,277,10,28]
["Chlorhexidine","Chlorhexidine","D002710",155,19,34,6,16,1,27]
["Loratadine","Loratadine","D017336",42,48,7,0,5,0,27]
["Streptomycin","Streptomycin","D013307",158,42,1,3,14,13,27]
["Menthol","Menthol","D008610",18,30,8,0,13,3,25]
["Neomycin","Neomycin","D009355",125,29,7,0,33,2,24]
["Oxymetazoline","Oxymetazoline","D010109",0,76,0,0,0,0,24]
["Beclomethasone","Beclomethasone","D001507",11,84,7,3,5,0,23]
["Ephedrine","Ephedrine","D004809",188,36,0,2,4,0,23]
["Polyethylene","Polyethylene","D020959",37,7,34,0,8,1,23]
["Polytetrafluoroethylene","Polytetrafluoroethylene","D011138",36,30,35,20,8,0,23]
["Sulfur Dioxide","Sulfur Dioxide","D013458",192,50,13,8,44,1,22]
["xylometazoline","xylometazoline","C009695",0,58,0,2,0,0,22]
["Cisplatin","Cisplatin","D002945",361,161,1814,70,4696,40,21]
["Methotrexate","Methotrexate","D008727",420,115,245,9,368,10,21]
["Polyvinyl Alcohol","Polyvinyl Alcohol","D011142",310,20,133,1,18,0,21]
["Tetracycline","Tetracycline","D013752",450,42,46,7,28,5,21]
["Cyclophosphamide","Cyclophosphamide","D003520",95,97,219,42,412,19,20]
["polyvinyl alcohol formaldehyde foam","polyvinyl alcohol formaldehyde foam","C027490",0,10,0,0,0,0,20]
["Capsaicin","Capsaicin","D002211",199,144,163,3,293,3,19]
["Cetirizine","Cetirizine","D017332",48,43,0,1,2,3,19]
["Dexamethasone","Dexamethasone","D003907",333,198,583,63,1378,16,19]
["imiquimod","imiquimod","C056493",2,8,50,5,82,0,19]
["Saline Solution, Hypertonic","Saline Solution, Hypertonic","D012462",127,52,14,0,47,0,19]
["nitrosobis(2-oxopropyl)amine","nitrosobis(2-oxopropyl)amine","C013622",4,6,3,0,4,6,18]
["Warfarin","Warfarin","D014859",124,247,8,1,12,1,18]
["Norepinephrine","Norepinephrine","D009638",781,176,90,6,133,4,17]
["Chlorpheniramine","Chlorpheniramine","D002744",56,13,2,0,4,0,16]
["enterotoxin F, Staphylococcal","enterotoxin F, Staphylococcal","C030107",16,12,30,0,13,4,16]
["Fluorouracil","Fluorouracil","D005472",301,71,910,56,1283,13,16]
["Chloramphenicol","Chloramphenicol","D002701",168,23,15,0,17,3,15]
["Cromolyn Sodium","Cromolyn Sodium","D004205",14,56,11,2,13,0,15]
["Durapatite","Durapatite","D017886",799,42,906,19,97,2,15]
["Fluticasone","Fluticasone","D000068298",11,116,26,4,24,0,15]
["Glutaral","Glutaral","D005976",234,18,20,0,5,1,15]
["Particulate Matter","Particulate Matter","D052638",271,31,113,8,205,15,15]
["Rifampin","Rifampin","D012293",118,32,21,3,38,13,15]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C68,B68)","v":"vinyl acetate"},"vinyl acetate","C011566",19,9,1,2,2,0,15]
["alachlor","alachlor","C000188",35,17,0,6,4,0,14]
["Chitosan","Chitosan","D048271",3722,103,1285,26,416,6,14]
["Halothane","Halothane","D006221",646,177,3,0,11,5,14]
["Hempa","Hempa","D006492",6,10,0,2,0,2,14]
["levocetirizine","levocetirizine","C472067",6,11,0,1,2,0,14]
["naphthalene","naphthalene","C031721",71,36,31,0,21,3,14]
["Procaine","Procaine","D011343",277,24,8,0,11,0,14]
["Propane","Propane","D011407",44,25,12,4,31,4,14]
["Serotonin","Serotonin","D012701",788,97,270,14,173,17,14]
["Terfenadine","Terfenadine","D016593",24,48,8,0,18,2,14]
["Clarithromycin","Clarithromycin","D017291",106,27,18,8,22,0,13]
["N,N'-dinitrosopiperazine","N,N'-dinitrosopiperazine","C026156",2,4,2,0,2,0,13]
["Povidone-Iodine","Povidone-Iodine","D011206",34,15,20,0,6,1,13]
["Propofol","Propofol","D015742",182,22,87,2,331,0,13]
["Tea","Tea","D013662",318,17,289,35,482,11,13]
["Tobacco Smoke Pollution","Tobacco Smoke Pollution","D014028",14,40,53,23,88,9,13]
["Triamcinolone","Triamcinolone","D014221",17,63,13,3,14,0,13]
["Acrolein","Acrolein","D000171",70,33,72,12,152,14,12]
["Chloroform","Chloroform","D002725",126,46,4,1,4,2,12]
["desloratadine","desloratadine","C121345",17,22,1,0,1,0,12]
["Dioctyl Sulfosuccinic Acid","Dioctyl Sulfosuccinic Acid","D004143",48,0,1,0,0,0,12]
["Erythromycin","Erythromycin","D004917",305,23,41,1,33,15,12]
["hydrazine","hydrazine","C029424",47,7,16,4,6,1,12]
["Mometasone Furoate","Mometasone Furoate","D000068656",6,60,0,3,5,1,12]
["Prednisone","Prednisone","D011241",26,112,9,6,26,1,12]
["Propranolol","Propranolol","D011433",482,53,78,15,69,0,12]
["Asbestos","Asbestos","D001194",28,2,10,35,53,9,11]
["Hydrogen Sulfide","Hydrogen Sulfide","D006862",383,41,217,18,378,5,11]
["Oxytetracycline","Oxytetracycline","D010118",195,18,1,2,11,0,11]
["1,2-dibromo-3-chloropropane","1,2-dibromo-3-chloropropane","C007318",0,13,0,0,3,0,10]
["1,4-dioxane","1,4-dioxane","C025223",25,4,5,0,0,0,10]
["Amphotericin B","Amphotericin B","D000666",229,38,21,0,51,3,10]
["Dopamine","Dopamine","D004298",915,106,268,22,800,26,10]
["Methylprednisolone","Methylprednisolone","D008775",123,91,51,7,145,0,10]
["montelukast","montelukast","C093875",12,23,33,1,26,0,10]
["Nitrogen Dioxide","Nitrogen Dioxide","D009585",83,32,8,2,16,3,10]
["Nitrous Oxide","Nitrous Oxide","D009609",396,19,3,0,15,1,10]
["N-nitrosomethyl-2-hydroxypropylamine","N-nitrosomethyl-2-hydroxypropylamine","C028132",0,0,0,0,0,0,10]
["N-Nitrosopyrrolidine","N-Nitrosopyrrolidine","D009242",8,8,2,0,0,1,10]
["Phenylpropanolamine","Phenylpropanolamine","D010665",43,15,2,0,2,0,10]
["Platelet Activating Factor","Platelet Activating Factor","D010972",114,84,35,32,93,1,10]
["Prostaglandin D2","Prostaglandin D2","D015230",16,18,102,6,331,1,10]
["3-(methylnitrosamino)propionitrile","3-(methylnitrosamino)propionitrile","C042162",4,0,0,0,0,0,9]
["Acetylcholine","Acetylcholine","D000109",409,58,67,5,70,10,9]
["Atropine","Atropine","D001285",269,30,4,0,4,1,9]
["BCG Vaccine","BCG Vaccine","D001500",28,47,68,7,39,5,9]
["Cellulose","Cellulose","D002482",1792,11,172,2,38,27,9]
["Cyproheptadine","Cyproheptadine","D003533",10,10,4,0,6,0,9]
["diallylnitrosamine","diallylnitrosamine","C015125",0,0,0,0,0,0,9]
["diisopropanolnitrosamine","diisopropanolnitrosamine","C012457",4,5,3,1,0,8,9]
["Doxorubicin","Doxorubicin","D004317",1741,210,1588,81,3420,18,9]
["fluticasone furoate","fluticasone furoate","C523187",0,12,2,0,0,0,9]
["Fusidic Acid","Fusidic Acid","D005672",12,16,2,0,0,1,9]
["Hexachlorophene","Hexachlorophene","D006582",18,3,2,0,2,0,9]
["Hydrochloric Acid","Hydrochloric Acid","D006851",931,52,8,6,17,2,9]
["Methylmethacrylate","Methylmethacrylate","D020366",26,17,12,6,0,0,9]
["Naphazoline","Naphazoline","D009278",12,13,0,0,0,1,9]
["Phenacetin","Phenacetin","D010615",30,26,0,0,0,1,9]
["Polymethyl Methacrylate","Polymethyl Methacrylate","D019904",141,25,76,7,32,0,9]
["remifentanil","remifentanil","C071741",11,1,4,0,28,0,9]
["Restylane","Restylane","C445361",0,5,0,0,0,0,9]
["Toluene","Toluene","D014050",165,48,30,1,147,13,9]
["Urea","Urea","D014508",1690,37,293,8,151,6,9]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C132,B132)","v":"1,4-dichloro-2-butene"},"1,4-dichloro-2-butene","C010709",0,0,0,0,0,0,8]
["2,6-xylidine","2,6-xylidine","C007766",6,9,0,0,0,0,8]
["azelastine","azelastine","C020976",2,30,2,2,0,0,8]
["Azithromycin","Azithromycin","D017963",93,11,20,1,39,0,8]
["Cellulose, Oxidized","Cellulose, Oxidized","D002483",18,5,10,0,2,0,8]
["Chlortetracycline","Chlortetracycline","D002751",74,11,0,0,1,0,8]
["Methacholine Chloride","Methacholine Chloride","D016210",16,49,10,0,0,0,8]
["methyl iodide","methyl iodide","C014055",6,5,0,0,0,0,8]
["Penicillin G","Penicillin G","D010400",273,17,4,0,4,2,8]
["Prednisolone","Prednisolone","D011239",140,121,42,23,92,2,8]
["Rubber","Rubber","D012408",99,3,2,0,0,0,8]
["sulfuric acid","sulfuric acid","C033158",143,4,2,8,0,0,8]
["Tetracaine","Tetracaine","D013748",99,7,2,0,2,0,8]
["Vitamin A","Vitamin A","D014801",276,55,99,153,85,7,8]
["Acetic Acid","Acetic Acid","D019342",681,31,30,11,58,12,7]
["Caffeine","Caffeine","D002110",342,24,86,2,241,14,7]
["CD3 Complex","CD3 Complex","D017252",6,6,141,2,164,7,7]
["Ethylene Dibromide","Ethylene Dibromide","D015946",6,5,0,0,0,4,7]
["Fluorescein","Fluorescein","D019793",186,18,3,7,16,0,7]
["Heparin","Heparin","D006493",929,234,359,129,126,32,7]
["Heroin","Heroin","D003932",50,16,3,0,30,0,7]
["Hydrogen Peroxide","Hydrogen Peroxide","D006861",2815,133,435,18,2274,78,7]
["Itraconazole","Itraconazole","D017964",67,8,31,7,7,0,7]
["Ivermectin","Ivermectin","D007559",46,5,19,1,20,5,7]
["Ketorolac Tromethamine","Ketorolac Tromethamine","D020911",22,4,2,0,0,0,7]
["Niacinamide","Niacinamide","D009536",210,57,543,47,561,4,7]
["N-vinyl-2-pyrrolidinone","N-vinyl-2-pyrrolidinone","C042670",18,0,4,0,4,0,7]
["Oseltamivir","Oseltamivir","D053139",18,8,5,1,6,0,7]
["phenethyl isothiocyanate","phenethyl isothiocyanate","C058305",6,2,75,2,187,1,7]
["satratoxin G","satratoxin G","C028268",0,4,2,0,18,0,7]
["Sumatriptan","Sumatriptan","D018170",26,6,0,0,0,0,7]
["Tetanus Toxoid","Tetanus Toxoid","D013745",32,20,18,0,9,0,7]
["Tripelennamine","Tripelennamine","D014309",6,2,0,0,0,0,7]
["urea formaldehyde foam","urea formaldehyde foam","C028278",2,0,0,0,0,0,7]
["Vincristine","Vincristine","D014750",54,40,77,5,204,1,7]
["9,10-Dimethyl-1,2-benzanthracene","9,10-Dimethyl-1,2-benzanthracene","D015127",8,20,54,29,94,18,6]
["Acetaminophen","Acetaminophen","D000082",450,386,46,1,249,3,6]
["acetochlor","acetochlor","C043377",16,4,2,0,5,4,6]
["acrylic acid","acrylic acid","C036658",141,11,29,0,4,0,6]
["Amoxicillin","Amoxicillin","D000658",165,8,7,4,5,0,6]
["Ascorbic Acid","Ascorbic Acid","D001205",1498,86,356,31,637,36,6]
["Carmustine","Carmustine","D002330",26,11,28,3,40,4,6]
["catechol","catechol","C034221",141,0,23,0,10,4,6]
["Choline","Choline","D002794",318,23,49,2,77,11,6]
["Chondroitin","Chondroitin","D002807",150,3,7,1,4,0,6]
["Clotrimazole","Clotrimazole","D003022",36,0,17,3,28,0,6]
["Crack Cocaine","Crack Cocaine","D016578",2,11,2,0,2,2,6]
["decalin","decalin","C007229",0,0,8,0,0,0,6]
["Dinoprostone","Dinoprostone","D015232",226,53,441,48,319,4,6]
["HhAntag691","HhAntag691","C538724",4,2,24,0,20,0,6]
["Lindane","Lindane","D001556",62,23,12,0,16,1,6]
["Methyl Chloride","Methyl Chloride","D008737",10,1,0,0,0,0,6]
["methylethyl ketone","methylethyl ketone","C005222",4,2,0,0,0,0,6]
["N-amyl-N-methylnitrosamine","N-amyl-N-methylnitrosamine","C025033",2,2,0,0,0,0,6]
["Niacin","Niacin","D009525",126,10,24,2,31,4,6]
["N-nitrosomethyl-2-oxopropylamine","N-nitrosomethyl-2-oxopropylamine","C028133",0,0,0,0,0,0,6]
["N-nitroso-N'-methylpiperazine","N-nitroso-N'-methylpiperazine","C014710",0,4,0,0,0,0,6]
["Novobiocin","Novobiocin","D009675",40,0,53,0,17,1,6]
["Oxacillin","Oxacillin","D010068",30,5,0,0,0,1,6]
["Pentachlorophenol","Pentachlorophenol","D010416",222,6,6,4,23,1,6]
["Poloxamer","Poloxamer","D020442",124,15,80,1,79,0,6]
["Prostaglandins E","Prostaglandins E","D011458",185,18,10,6,6,0,6]
["resorcinol","resorcinol","C031389",48,0,12,0,2,0,6]
["Rubella Vaccine","Rubella Vaccine","D012411",2,3,2,0,1,0,6]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C196,B196)","v":"Sodium, Dietary"},"Sodium, Dietary","D012982",166,8,2,2,3,0,6]
["tetrahydrozoline","tetrahydrozoline","C005810",0,0,0,0,0,0,6]
["Vinyl Chloride","Vinyl Chloride","D014752",10,1,0,2,2,15,6]
["Vitamin B 12","Vitamin B 12","D014805",481,41,40,10,41,19,6]
["Vitamin D","Vitamin D","D014807",101,34,383,10,262,2,6]
["1,4-bis(2-(3,5-dichloropyridyloxy))benzene","1,4-bis(2-(3,5-dichloropyridyloxy))benzene","C028474",2,0,19,0,10,1,5]
["2-Propanol","2-Propanol","D019840",37,1,0,0,2,1,5]
["Adrenochrome","Adrenochrome","D000323",36,3,0,0,0,0,5]
["Alprostadil","Alprostadil","D000527",83,36,31,13,56,0,5]
["chlorhexidine gluconate","chlorhexidine gluconate","C010882",35,7,6,5,8,0,5]
["Clindamycin","Clindamycin","D002981",77,12,2,0,0,0,5]
["Deoxyglucose","Deoxyglucose","D003847",128,17,131,5,203,10,5]
["Diazepam","Diazepam","D003975",267,23,21,0,20,1,5]
["enterotoxin A, Staphylococcal","enterotoxin A, Staphylococcal","C026066",32,6,34,0,21,0,5]
["fexofenadine","fexofenadine","C093230",10,19,2,0,2,0,5]
["Folic Acid","Folic Acid","D005492",1034,38,376,16,343,34,5]
["Framycetin","Framycetin","D005601",10,2,12,3,0,1,5]
["Gasoline","Gasoline","D005742",76,19,5,0,10,5,5]
["Guanine","Guanine","D006147",367,12,106,10,163,147,5]
["Heptavalent Pneumococcal Conjugate Vaccine","Heptavalent Pneumococcal Conjugate Vaccine","D000069443",0,0,2,0,0,0,5]
["Hydrogel, Polyethylene Glycol Dimethacrylate","Hydrogel, Polyethylene Glycol Dimethacrylate","D020136",496,11,390,13,59,0,5]
["Keratan Sulfate","Keratan Sulfate","D007632",26,1,24,3,19,1,5]
["Ketamine","Ketamine","D007649",283,22,47,8,182,0,5]
["Lactic Acid","Lactic Acid","D019344",3228,68,1001,39,242,16,5]
["Methanol","Methanol","D000432",546,66,56,1,63,9,5]
["methyl isocyanate","methyl isocyanate","C008461",4,14,0,0,3,5,5]
["Metoclopramide","Metoclopramide","D008787",121,16,3,0,4,0,5]
["Olopatadine Hydrochloride","Olopatadine Hydrochloride","D000069605",0,9,0,0,2,0,5]
["Paraffin","Paraffin","D010232",24,9,2,2,1,0,5]
["Petroleum","Petroleum","D010578",333,33,16,2,18,7,5]
["Phenytoin","Phenytoin","D010672",209,81,33,2,19,0,5]
["Potassium Iodide","Potassium Iodide","D011193",30,3,4,0,18,0,5]
["propylene","propylene","C013658",2,1,14,0,0,0,5]
["Ranitidine","Ranitidine","D011899",631,4,3,4,6,0,5]
["Reserpine","Reserpine","D012110",70,43,6,0,3,0,5]
["rupatadine","rupatadine","C103639",2,1,0,0,0,0,5]
["Saccharin","Saccharin","D012439",65,9,16,0,8,1,5]
["Sodium Chloride, Dietary","Sodium Chloride, Dietary","D017673",89,3,9,14,23,2,5]
["Sodium Nitrite","Sodium Nitrite","D012977",145,10,24,5,17,1,5]
["thioperamide","thioperamide","C052075",0,0,0,0,2,0,5]
["tramazoline","tramazoline","C005370",0,3,0,0,0,0,5]
["Urethane","Urethane","D014520",63,16,15,12,15,3,5]
["zolmitriptan","zolmitriptan","C089750",18,6,0,0,0,0,5]
["1,6-hexamethylene diisocyanate","1,6-hexamethylene diisocyanate","C015262",4,4,3,0,0,0,4]
["2-butanone oxime","2-butanone oxime","C104767",0,1,0,0,0,0,4]
["6-Aminonicotinamide","6-Aminonicotinamide","D015120",2,4,8,0,10,1,4]
["allyl isothiocyanate","allyl isothiocyanate","C004471",18,1,21,3,30,0,4]
["Amantadine","Amantadine","D000547",61,4,19,0,26,2,4]
["Amiloride","Amiloride","D000584",686,45,30,4,58,7,4]
["Amoxicillin-Potassium Clavulanate Combination","Amoxicillin-Potassium Clavulanate Combination","D019980",10,3,0,0,0,0,4]
["Ampicillin","Ampicillin","D000667",205,12,2,2,2,2,4]
["Astemizole","Astemizole","D016589",4,6,7,0,8,0,4]
["baysilon","baysilon","C013830",72,4,85,0,3,0,4]
["Carbon Monoxide","Carbon Monoxide","D002248",624,93,69,9,261,2,4]
["Cefazolin","Cefazolin","D002437",49,2,2,0,0,1,4]
["Chitin","Chitin","D002686",834,24,54,4,30,12,4]
["Cholesterol","Cholesterol","D002784",977,94,384,47,581,22,4]
["chromium trioxide","chromium trioxide","C028801",2,0,2,0,2,4,4]
["cidofovir","cidofovir","C059262",10,7,16,4,33,0,4]
["cresidine","cresidine","C013453",0,2,0,2,0,0,4]
["Cytosine","Cytosine","D003596",332,12,40,6,58,66,4]
["Dacarbazine","Dacarbazine","D003606",32,24,422,18,567,7,4]
["DDT","DDT","D003634",88,6,15,4,34,0,4]
["Diethylhexyl Phthalate","Diethylhexyl Phthalate","D004051",26,21,61,0,176,3,4]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C260,B260)","v":"dimethyl-4-toluidine"},"dimethyl-4-toluidine","C015835",0,0,0,0,0,0,4]
["Dinoprost","Dinoprost","D015237",83,11,15,5,57,0,4]
["enterotoxin B, staphylococcal","enterotoxin B, staphylococcal","C031818",22,22,56,1,90,3,4]
["Hypochlorous Acid","Hypochlorous Acid","D006997",214,10,9,0,41,1,4]
["Ipratropium","Ipratropium","D009241",22,70,0,0,4,0,4]
["isoborneol","isoborneol","C022871",4,11,6,0,14,0,4]
["Isoflurane","Isoflurane","D007530",204,44,54,1,276,2,4]
["Isoniazid","Isoniazid","D007538",176,32,16,1,35,7,4]
["Isotretinoin","Isotretinoin","D015474",8,21,38,13,62,0,4]
["ivalon sponge","ivalon sponge","C026699",0,1,0,1,0,0,4]
["Ketorolac","Ketorolac","D020910",22,7,4,1,4,0,4]
["Leukotriene E4","Leukotriene E4","D017999",4,8,1,0,4,0,4]
["Maltose","Maltose","D008320",194,4,4,0,2,3,4]
["Metronidazole","Metronidazole","D008795",192,16,22,7,11,5,4]
["Mitomycin","Mitomycin","D016685",144,61,157,9,255,22,4]
["Morphine","Morphine","D009020",360,28,79,18,240,4,4]
["Nitrosomethylurethane","Nitrosomethylurethane","D009605",0,1,0,4,0,0,4]
["N-nitrosallyl-2-oxopropylamine","N-nitrosallyl-2-oxopropylamine","C041198",0,0,0,0,0,0,4]
["N-nitroso-2-hydroxypropylamine","N-nitroso-2-hydroxypropylamine","C041197",0,0,0,0,0,0,4]
["N-nitrosoallyl-2,3-dihydroxypropylamine","N-nitrosoallyl-2,3-dihydroxypropylamine","C041199",0,0,0,0,0,0,4]
["N-nitroso-N-allyl-N-ethanolamine","N-nitroso-N-allyl-N-ethanolamine","C041196",0,0,0,0,0,0,4]
["N'-nitrosonornicotine-N-oxide","N'-nitrosonornicotine-N-oxide","C039742",0,0,0,0,0,0,4]
["O-(6)-methylguanine","O-(6)-methylguanine","C008449",10,5,9,4,29,26,4]
["Phenylethyl Alcohol","Phenylethyl Alcohol","D010626",47,10,129,6,221,3,4]
["phenylglycidyl ether","phenylglycidyl ether","C016050",4,0,0,0,0,0,4]
["Povidone","Povidone","D011205",216,15,31,2,25,0,4]
["Propanidid","Propanidid","D011410",90,1,0,0,0,0,4]
["propylene dichloride","propylene dichloride","C004765",0,0,0,4,0,1,4]
["ramatroban","ramatroban","C063119",2,10,0,0,0,0,4]
["sevoflurane","sevoflurane","C009250",97,12,42,0,205,1,4]
["Sildenafil Citrate","Sildenafil Citrate","D000068677",55,24,49,2,84,2,4]
["Silicon Dioxide","Silicon Dioxide","D012822",2531,39,394,4,348,2,4]
["Skatole","Skatole","D012862",16,27,2,0,9,0,4]
["Sodium Bicarbonate","Sodium Bicarbonate","D017693",1481,10,8,0,9,0,4]
["Starch","Starch","D013213",1108,31,66,2,28,19,4]
["Styrene","Styrene","D020058",46,16,13,0,19,3,4]
["sulfanilamide","sulfanilamide","C036944",42,4,0,0,4,0,4]
["sunitinib","sunitinib","C473478",2,16,239,115,184,3,4]
["Tegafur","Tegafur","D005641",14,6,19,14,42,0,4]
["Tolmetin","Tolmetin","D014046",40,0,2,0,2,0,4]
["Tretinoin","Tretinoin","D014212",102,61,1066,101,1513,16,4]
["Zinc Sulfate","Zinc Sulfate","D019287",36,27,29,2,34,2,4]
["1,1-dichloro-1-fluoroethane","1,1-dichloro-1-fluoroethane","C068320",0,0,0,0,0,0,3]
["1,2-epoxybutane","1,2-epoxybutane","C027488",4,2,0,0,0,0,3]
["1,6-diaminohexane","1,6-diaminohexane","C007297",8,0,2,0,2,0,3]
["17-phenylprostaglandin F2alpha","17-phenylprostaglandin F2alpha","C027042",0,0,0,0,0,0,3]
["1-nitropyrene","1-nitropyrene","C032668",4,0,2,0,11,7,3]
["1-nitrosopiperazine","1-nitrosopiperazine","C014711",4,3,0,0,0,0,3]
["1-Propanol","1-Propanol","D000433",49,11,4,0,0,2,3]
["2-(4-methoxyphenyl)-N-(4-methylbenzyl)-N-(1-methylpiperidin-4-yl)acetamide","2-(4-methoxyphenyl)-N-(4-methylbenzyl)-N-(1-methylpiperidin-4-yl)acetamide","C492669",0,0,0,0,0,0,3]
["2,2-dichloro-1,1,1-trifluoroethane","2,2-dichloro-1,1,1-trifluoroethane","C067411",0,3,0,0,0,0,3]
["2,4,5-trichlorophenol","2,4,5-trichlorophenol","C009534",8,0,0,0,0,0,3]
["2,6-dimethoxy-1,4-benzoquinone","2,6-dimethoxy-1,4-benzoquinone","C030511",0,0,0,0,0,0,3]
["2-chloro-4-toluidine","2-chloro-4-toluidine","C518671",0,0,0,0,0,0,3]
["3-xylene","3-xylene","C031285",0,6,0,0,0,0,3]
["4-(methylnitrosoamino)-4-(3-pyridyl)-1-butanol","4-(methylnitrosoamino)-4-(3-pyridyl)-1-butanol","C051577",0,0,0,0,0,0,3]
["4,16-androstadien-3-one","4,16-androstadien-3-one","C003524",0,0,0,0,0,0,3]
["4-Nitroquinoline-1-oxide","4-Nitroquinoline-1-oxide","D015112",12,0,21,4,13,9,3]
["Acetone","Acetone","D000096",200,16,6,4,6,3,3]
["Acyclovir","Acyclovir","D000212",105,31,6,0,21,5,3]
["Albuterol","Albuterol","D000420",133,24,27,1,22,0,3]
["allyl glycidyl ether","allyl glycidyl ether","C054361",6,4,0,4,0,0,3]
["Aminophylline","Aminophylline","D000628",107,1,1,0,11,0,3]
["Anabasine","Anabasine","D000691",8,0,0,0,0,0,3]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C324,B324)","v":"asphalt"},"asphalt","C006647",16,1,3,0,2,0,3]
["Benzene","Benzene","D001554",125,16,60,4,112,12,3]
["benzoylecgonine","benzoylecgonine","C005618",34,1,0,0,0,0,3]
["benzyl isothiocyanate","benzyl isothiocyanate","C031403",8,2,54,4,112,0,3]
["beta-myrcene","beta-myrcene","C008574",4,0,0,0,0,2,3]
["bis(2-chloroethoxy)methane","bis(2-chloroethoxy)methane","C495703",2,2,0,0,0,0,3]
["bis(4-nitrophenyl)phosphate","bis(4-nitrophenyl)phosphate","C002887",6,0,0,0,0,0,3]
["Bis(Chloromethyl) Ether","Bis(Chloromethyl) Ether","D001725",0,0,0,0,0,0,3]
["Bupivacaine","Bupivacaine","D002045",327,36,24,2,93,0,3]
["butachlor","butachlor","C054409",6,4,0,0,2,0,3]
["butyl acetate","butyl acetate","C006848",12,5,0,0,0,0,3]
["caffeoylxanthiazonoside","caffeoylxanthiazonoside","C000594078",0,0,0,0,0,0,3]
["Calcium Sulfate","Calcium Sulfate","D002133",93,1,31,0,2,0,3]
["Carboplatin","Carboplatin","D016190",34,23,110,12,214,2,3]
["Cephalexin","Cephalexin","D002506",74,6,2,0,2,0,3]
["CGS 27023A","CGS 27023A","C097658",0,0,0,2,2,0,3]
["Chlormethiazole","Chlormethiazole","D002719",12,4,0,0,0,0,3]
["Chlorpromazine","Chlorpromazine","D002746",294,34,17,0,27,2,3]
["choline magnesium trisalicylate","choline magnesium trisalicylate","C017959",0,0,0,0,0,0,3]
["chromic acid","chromic acid","C034944",4,4,0,0,0,0,3]
["chrysoidine","chrysoidine","C005562",6,0,0,0,0,0,3]
["Citalopram","Citalopram","D015283",46,3,21,0,19,2,3]
["Clozapine","Clozapine","D003024",37,11,15,1,29,0,3]
["Coffee","Coffee","D003069",178,2,26,1,26,2,3]
["copper (II) diacetyl-di(N(4)-methylthiosemicarbazone)","copper (II) diacetyl-di(N(4)-methylthiosemicarbazone)","C089548",2,0,10,2,3,0,3]
["Corn Oil","Corn Oil","D003314",20,2,4,0,11,0,3]
["Curcumin","Curcumin","D003474",320,66,1632,87,2471,7,3]
["dermonecrotic toxin, Pasteurella multocida","dermonecrotic toxin, Pasteurella multocida","C052804",4,6,0,0,0,0,3]
["Diacetyl","Diacetyl","D003931",76,9,3,0,9,2,3]
["diethylmethylnitrosourea","diethylmethylnitrosourea","C026466",0,0,0,0,0,0,3]
["Dimenhydrinate","Dimenhydrinate","D004111",7,2,0,0,0,0,3]
["dimethylcarbamyl chloride","dimethylcarbamyl chloride","C001036",2,1,0,0,0,0,3]
["dimethylnitramine","dimethylnitramine","C013962",0,2,0,0,0,0,3]
["Disulfiram","Disulfiram","D004221",39,18,59,4,74,1,3]
["Drinking Water","Drinking Water","D060766",317,0,14,0,9,8,3]
["EBV-encoded nuclear antigen 1","EBV-encoded nuclear antigen 1","C417029",4,0,24,1,10,2,3]
["Edetic Acid","Edetic Acid","D004492",872,20,20,3,18,4,3]
["Enflurane","Enflurane","D004737",92,21,0,0,0,1,3]
["Epichlorohydrin","Epichlorohydrin","D004811",26,2,1,0,3,0,3]
["erythritol anhydride","erythritol anhydride","C007366",12,5,6,0,9,12,3]
["ethyl acrylate","ethyl acrylate","C040833",13,8,0,0,2,0,3]
["ethyl chloroformate","ethyl chloroformate","C007658",2,2,0,0,0,0,3]
["ethylbenzene","ethylbenzene","C004912",8,2,0,0,12,0,3]
["fenoxazoline","fenoxazoline","C040400",0,1,0,0,0,0,3]
["Fentanyl","Fentanyl","D005283",279,12,16,0,20,2,3]
["FluLaval","FluLaval","C517981",0,0,0,0,0,0,3]
["flunisolide","flunisolide","C007734",0,24,0,2,2,0,3]
["Fluocinolone Acetonide","Fluocinolone Acetonide","D005446",6,55,9,2,2,0,3]
["fluorescein isothiocyanate dextran","fluorescein isothiocyanate dextran","C015219",72,18,0,1,0,0,3]
["furfuryl alcohol","furfuryl alcohol","C012986",8,2,2,0,0,0,3]
["Gadolinium DTPA","Gadolinium DTPA","D019786",36,27,14,91,11,0,3]
["Glycerol","Glycerol","D005990",690,29,97,6,39,18,3]
["Haloperidol","Haloperidol","D006220",68,8,22,0,56,1,3]
["histamine phosphate","histamine phosphate","C027556",4,9,0,1,0,0,3]
["Hydroxyurea","Hydroxyurea","D006918",26,18,59,5,100,6,3]
["Hydroxyzine","Hydroxyzine","D006919",24,16,0,0,0,0,3]
["hylan-B gel","hylan-B gel","C445362",0,1,0,0,0,0,3]
["iloperidone","iloperidone","C081732",0,0,0,0,0,0,3]
["Indocyanine Green","Indocyanine Green","D007208",38,50,22,123,39,0,3]
["indole-3-carbinol","indole-3-carbinol","C016517",20,3,92,2,161,3,3]
["Industrial Waste","Industrial Waste","D007220",2486,3,37,0,5,5,3]
["Isoproterenol","Isoproterenol","D007545",296,269,24,1,108,1,3]
["ivacaftor","ivacaftor","C545203",8,3,0,0,0,2,3]
["Kanamycin","Kanamycin","D007612",86,14,1,0,10,3,3]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C388,B388)","v":"Lactose"},"Lactose","D007785",622,5,23,0,9,8,3]
["Magnesium Oxide","Magnesium Oxide","D008277",115,0,13,0,8,0,3]
["Mannitol","Mannitol","D008353",264,42,11,0,32,4,3]
["Medpor","Medpor","C084562",0,0,0,2,0,0,3]
["Meperidine","Meperidine","D008614",195,5,2,0,7,0,3]
["Methyl Methanesulfonate","Methyl Methanesulfonate","D008741",26,6,4,0,31,26,3]
["methyl(acetoxymethyl)nitrosamine","methyl(acetoxymethyl)nitrosamine","C014659",0,0,0,0,0,1,3]
["Methylene Blue","Methylene Blue","D008751",590,18,16,40,51,3,3]
["Molsidomine","Molsidomine","D008981",33,6,2,0,69,0,3]
["niguldipine","niguldipine","C054074",4,0,0,0,0,0,3]
["nitrosobenzylmethylamine","nitrosobenzylmethylamine","C014707",2,5,4,2,10,1,3]
["N-nitrodiethylamine","N-nitrodiethylamine","C031406",0,0,0,0,0,0,3]
["N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine","N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine","C013624",0,0,0,0,0,0,3]
["N-nitroso-2,6-dimethylmorpholine","N-nitroso-2,6-dimethylmorpholine","C014130",0,2,0,0,0,0,3]
["N'-nitrosoanatabine","N'-nitrosoanatabine","C032978",2,0,0,0,0,0,3]
["N-nitrosodiethanolamine","N-nitrosodiethanolamine","C014129",8,1,2,0,0,0,3]
["N-nitrosomethyl-2,3-dihydroxypropylamine","N-nitrosomethyl-2,3-dihydroxypropylamine","C040535",0,0,0,0,0,0,3]
["N-nitrosomethyldecylamine","N-nitrosomethyldecylamine","C029647",0,0,0,0,0,0,3]
["N-nitrosomethyldodecylamine","N-nitrosomethyldodecylamine","C009914",0,0,0,2,0,0,3]
["N-nitrosomethylnonylamine","N-nitrosomethylnonylamine","C029646",0,0,0,0,0,0,3]
["N-nitrosomethyloctylamine","N-nitrosomethyloctylamine","C029645",0,0,0,0,0,0,3]
["N-nitrosomethyltetradecylamine","N-nitrosomethyltetradecylamine","C029648",0,0,0,0,0,0,3]
["N-nitrosomethylundecylamine","N-nitrosomethylundecylamine","C017919",0,0,0,0,0,0,3]
["N-nitrosopiperidine","N-nitrosopiperidine","C002743",2,6,4,0,8,0,3]
["N-trimethyl chitosan chloride","N-trimethyl chitosan chloride","C118071",47,14,18,2,12,0,3]
["Ofloxacin","Ofloxacin","D015242",181,12,12,0,17,2,3]
["Oleandomycin","Oleandomycin","D009827",42,0,0,0,0,0,3]
["Oleic Acid","Oleic Acid","D019301",203,11,81,1,152,6,3]
["oleoresins","oleoresins","C018620",4,3,6,0,0,0,3]
["Ondansetron","Ondansetron","D017294",43,9,6,0,0,0,3]
["p-Aminoazobenzene","p-Aminoazobenzene","D010128",10,0,2,0,0,0,3]
["Penicillin G Procaine","Penicillin G Procaine","D010402",8,3,0,0,0,0,3]
["Pentaerythritol Tetranitrate","Pentaerythritol Tetranitrate","D010417",8,0,0,0,0,0,3]
["Pentetic Acid","Pentetic Acid","D004369",84,26,6,10,11,0,3]
["Petrolatum","Petrolatum","D010577",6,6,0,0,0,0,3]
["Phenoxybenzamine","Phenoxybenzamine","D010643",77,20,1,0,0,0,3]
["phenylisothiocyanate","phenylisothiocyanate","C005441",6,0,2,1,2,0,3]
["Pilocarpine","Pilocarpine","D010862",137,14,13,0,16,1,3]
["polylactic acid-polyglycolic acid copolymer","polylactic acid-polyglycolic acid copolymer","C043435",458,16,579,18,151,0,3]
["propachlor","propachlor","C011088",6,2,0,0,1,0,3]
["Propiolactone","Propiolactone","D011420",11,1,2,0,2,1,3]
["Prostaglandins F, Synthetic","Prostaglandins F, Synthetic","D011461",15,1,8,0,22,0,3]
["Ro 28-2653","Ro 28-2653","C453902",0,2,0,1,2,0,3]
["Ro 31-9790","Ro 31-9790","C097661",2,0,0,0,2,0,3]
["rofecoxib","rofecoxib","C116926",6,2,23,7,34,0,3]
["rotigotine","rotigotine","C047508",10,2,0,0,0,0,3]
["Scopolamine Hydrobromide","Scopolamine Hydrobromide","D012601",46,7,4,0,20,0,3]
["sinigrin","sinigrin","C010330",6,0,6,0,3,0,3]
["Smog","Smog","D012905",6,6,0,2,0,0,3]
["sodium bichromate","sodium bichromate","C016104",0,6,0,0,2,0,3]
["Sodium Cyanide","Sodium Cyanide","D012966",36,1,2,0,10,0,3]
["Stainless Steel","Stainless Steel","D013193",153,6,87,0,11,0,3]
["Steam","Steam","D013227",46,5,3,1,1,0,3]
["sulforafan","sulforafan","C016766",6,2,106,0,204,0,3]
["Surgicel","Surgicel","C013695",2,2,0,0,0,0,3]
["Tacrolimus","Tacrolimus","D016559",59,48,165,5,281,8,3]
["tetramethylpyrazine","tetramethylpyrazine","C017953",12,7,98,7,158,0,3]
["Thiotepa","Thiotepa","D013852",36,8,8,5,2,1,3]
["Thiram","Thiram","D013893",18,0,0,1,6,0,3]
["tinazoline","tinazoline","C033219",0,2,0,0,0,0,3]
["Triamcinolone Acetonide","Triamcinolone Acetonide","D014222",32,81,32,24,49,0,3]
["Trimethoprim, Sulfamethoxazole Drug Combination","Trimethoprim, Sulfamethoxazole Drug Combination","D015662",34,3,4,0,2,2,3]
["Tromethamine","Tromethamine","D014325",601,11,0,0,2,0,3]
["WEB 2086","WEB 2086","C052518",0,2,2,2,4,0,3]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C452,B452)","v":"2,3-pentanedione"},"2,3-pentanedione","C013186",0,4,0,0,0,0,2]
["2-chloroethyl ethyl sulfide","2-chloroethyl ethyl sulfide","C031278",2,3,9,0,20,7,2]
["2-cyclohexen-1-one","2-cyclohexen-1-one","C028215",2,0,0,0,0,1,2]
["2-ethylhexyl lactate","2-ethylhexyl lactate","C114967",0,0,0,0,0,0,2]
["3,3'-iminodipropionitrile","3,3'-iminodipropionitrile","C008110",0,16,4,0,8,0,2]
["3-buten-2-one","3-buten-2-one","C057920",0,1,0,0,3,0,2]
["3-Iodobenzylguanidine","3-Iodobenzylguanidine","D019797",16,4,7,0,5,0,2]
["3-methylfuran","3-methylfuran","C039851",0,3,0,0,0,0,2]
["4'-hydroxypropranolol sulfate ester","4'-hydroxypropranolol sulfate ester","C040851",0,0,0,0,0,0,2]
["4-methylcyclohexyl-1,6-dicarboxylic acid anhydride","4-methylcyclohexyl-1,6-dicarboxylic acid anhydride","C051070",0,0,0,0,0,0,2]
["7-methylguanine","7-methylguanine","C008450",8,1,2,0,0,2,2]
["Acridine Orange","Acridine Orange","D000165",87,5,3,2,24,3,2]
["Agar","Agar","D000362",160,1,6,0,1,0,2]
["Alfentanil","Alfentanil","D015760",33,0,0,0,0,0,2]
["alginic acid","alginic acid","C008970",982,10,357,7,54,6,2]
["Amphetamine","Amphetamine","D000661",186,13,6,0,8,1,2]
["Arachidonic Acid","Arachidonic Acid","D016718",177,27,100,9,233,4,2]
["baicalin","baicalin","C038044",42,8,83,0,199,0,2]
["Benzo(a)pyrene","Benzo(a)pyrene","D001564",74,17,116,42,229,72,2]
["Benzocaine","Benzocaine","D001566",45,1,1,0,0,0,2]
["beta Carotene","beta Carotene","D019207",108,14,57,15,125,15,2]
["beta-1,3-glucan","beta-1,3-glucan","C033363",16,3,9,0,10,3,2]
["bone wax","bone wax","C055480",0,1,0,0,0,0,2]
["Brompheniramine","Brompheniramine","D001977",4,3,0,0,0,0,2]
["butyl methacrylate-vinylpyrrolidone copolymer","butyl methacrylate-vinylpyrrolidone copolymer","C054377",0,0,1,0,0,0,2]
["Calcium, Dietary","Calcium, Dietary","D002136",327,18,10,2,17,1,2]
["Camphor","Camphor","D002164",20,11,8,0,5,0,2]
["Carbachol","Carbachol","D002217",73,8,15,0,16,0,2]
["carbazochrome","carbazochrome","C073338",4,0,0,0,0,0,2]
["Carmine","Carmine","D002329",28,1,0,2,0,0,2]
["carmustine with prolifeprosan 20","carmustine with prolifeprosan 20","C453779",0,0,0,0,0,0,2]
["Catechin","Catechin","D002392",293,33,809,57,1336,3,2]
["Chlorophyll","Chlorophyll","D002734",372,16,39,1,84,12,2]
["Chloroquine","Chloroquine","D002738",350,14,135,4,190,1,2]
["CI 959","CI 959","C061662",0,2,0,0,0,0,2]
["Ciprofloxacin","Ciprofloxacin","D002939",374,20,72,0,47,13,2]
["Clonidine","Clonidine","D003000",72,8,2,1,8,0,2]
["Cloxacillin","Cloxacillin","D003023",54,0,0,0,0,0,2]
["Codeine","Codeine","D003061",77,9,0,0,6,0,2]
["daminozide","daminozide","C014499",4,0,0,0,0,0,2]
["Dental Amalgam","Dental Amalgam","D003723",97,7,1,0,0,0,2]
["Dermalive","Dermalive","C482306",0,0,0,0,0,0,2]
["Dexmedetomidine","Dexmedetomidine","D020927",26,5,12,0,106,0,2]
["Dextromethorphan","Dextromethorphan","D003915",28,1,6,0,5,0,2]
["di-2-ethylhexyl sebacate","di-2-ethylhexyl sebacate","C037634",0,0,0,0,0,0,2]
["diborane","diborane","C024731",0,0,0,0,0,0,2]
["dimethyl glutarate","dimethyl glutarate","C067353",0,4,0,0,0,0,2]
["dimethyl succinate","dimethyl succinate","C056451",0,4,0,0,0,0,2]
["dimethyladipate","dimethyladipate","C067354",0,4,0,0,0,0,2]
["dioxidine","dioxidine","C001077",2,3,0,0,0,4,2]
["Diphenhydramine","Diphenhydramine","D004155",65,14,2,0,7,0,2]
["divinyl benzene","divinyl benzene","C004985",14,3,1,0,0,0,2]
["Droperidol","Droperidol","D004329",54,2,0,0,0,0,2]
["Enbucrilate","Enbucrilate","D004659",23,11,17,8,18,0,2]
["Enoxaparin","Enoxaparin","D017984",14,28,22,6,10,0,2]
["estasol","estasol","C067355",0,5,0,0,0,0,2]
["ethyl lactate","ethyl lactate","C015866",4,0,0,0,0,0,2]
["Fluorescein-5-isothiocyanate","Fluorescein-5-isothiocyanate","D016650",169,26,5,4,18,1,2]
["Fluprednisolone","Fluprednisolone","D005477",0,4,0,0,0,0,2]
["flutropium bromide","flutropium bromide","C039778",0,0,0,0,0,0,2]
["Furaldehyde","Furaldehyde","D005662",118,14,16,0,20,2,2]
["Furosemide","Furosemide","D005665",343,38,2,1,4,0,2]
["geniposide","geniposide","C007835",6,4,16,0,38,0,2]
["Genistein","Genistein","D019833",80,11,572,37,730,8,2]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C516,B516)","v":"Gentian Violet"},"Gentian Violet","D005840",148,10,12,1,10,0,2]
["Glucose","Glucose","D005947",4247,208,1352,64,1988,80,2]
["glycofurol","glycofurol","C018557",0,2,0,0,0,0,2]
["Glycogen","Glycogen","D006003",377,22,24,9,19,13,2]
["Gutta-Percha","Gutta-Percha","D006171",16,2,1,0,0,0,2]
["Heparin, Low-Molecular-Weight","Heparin, Low-Molecular-Weight","D006495",29,31,52,34,49,0,2]
["human epithelial antigen-125","human epithelial antigen-125","C115012",2,0,2,4,0,0,2]
["Hydrofluoric Acid","Hydrofluoric Acid","D006858",26,13,0,0,2,0,2]
["iobitridol","iobitridol","C093233",2,1,0,0,2,0,2]
["Iohexol","Iohexol","D007472",21,9,4,4,32,0,2]
["isobutyl lactate","isobutyl lactate","C028445",0,0,0,0,0,0,2]
["Ketoconazole","Ketoconazole","D007654",86,10,9,0,17,1,2]
["K-Y jelly","K-Y jelly","C042973",0,0,0,0,0,0,2]
["Leucovorin","Leucovorin","D002955",56,6,8,0,11,0,2]
["Levofloxacin","Levofloxacin","D064704",76,1,11,0,11,0,2]
["Lomustine","Lomustine","D008130",6,2,2,0,7,5,2]
["Measles Vaccine","Measles Vaccine","D008458",10,11,16,0,9,1,2]
["mercaptoundecahydrododecaborate","mercaptoundecahydrododecaborate","C014651",0,1,1,0,3,0,2]
["Mercuric Chloride","Mercuric Chloride","D008627",56,33,22,0,67,3,2]
["Methoxsalen","Methoxsalen","D008730",10,8,16,1,57,21,2]
["methyl bromide","methyl bromide","C005218",6,24,0,4,0,2,2]
["Methylene Chloride","Methylene Chloride","D008752",24,0,10,1,13,4,2]
["MF59 oil emulsion","MF59 oil emulsion","C089950",5,3,6,0,1,0,2]
["Midazolam","Midazolam","D008874",102,15,10,0,32,0,2]
["milbemycin","milbemycin","C027837",2,0,0,0,0,0,2]
["Minocycline","Minocycline","D008911",43,17,83,10,225,1,2]
["Monocrotaline","Monocrotaline","D016686",6,5,35,3,28,1,2]
["mucicarmine","mucicarmine","C029618",0,0,0,2,0,0,2]
["myrtol","myrtol","C055632",0,2,0,0,0,0,2]
["N-Acetylneuraminic Acid","N-Acetylneuraminic Acid","D019158",152,5,37,2,39,18,2]
["n-butyl lactate","n-butyl lactate","C114966",0,0,0,0,0,0,2]
["Nedocromil","Nedocromil","D017835",2,10,1,0,0,0,2]
["Nicorandil","Nicorandil","D020108",24,3,10,0,41,0,2]
["Nitroprusside","Nitroprusside","D009599",158,14,23,1,165,2,2]
["N-methylformimino methyl ester","N-methylformimino methyl ester","C035481",0,2,0,0,0,0,2]
["O-deacetyl platelet activating factor","O-deacetyl platelet activating factor","C029271",4,10,0,5,2,0,2]
["oligonol","oligonol","C514283",0,0,2,0,9,0,2]
["Opium","Opium","D009892",14,0,0,4,2,0,2]
["Oxonic Acid","Oxonic Acid","D010094",8,2,19,7,29,0,2]
["Oxyphenbutazone","Oxyphenbutazone","D010113",28,4,0,0,0,0,2]
["parecoxib","parecoxib","C409945",0,1,5,0,13,0,2]
["Penicillin V","Penicillin V","D010404",42,3,1,0,0,1,2]
["Pentamidine","Pentamidine","D010419",10,6,12,0,14,2,2]
["Pentazocine","Pentazocine","D010423",67,11,0,0,4,0,2]
["petasin","petasin","C418727",0,0,2,0,0,0,2]
["phenethicillin","phenethicillin","C100209",0,0,0,0,0,0,2]
["Phenprocoumon","Phenprocoumon","D010644",2,16,0,0,0,0,2]
["phenylephrine, lidocaine drug combination","phenylephrine, lidocaine drug combination","C546419",0,0,0,0,0,0,2]
["Phosphorylcholine","Phosphorylcholine","D010767",170,3,139,3,245,2,2]
["piclamilast","piclamilast","C087566",0,2,2,0,2,0,2]
["Piroxicam","Piroxicam","D010894",132,11,14,2,50,0,2]
["Podophyllin","Podophyllin","D011033",2,4,0,0,1,0,2]
["polidocanol","polidocanol","C008976",14,23,4,5,9,0,2]
["polyacrylamide gels","polyacrylamide gels","C016680",56,5,9,0,1,0,2]
["Polydioxanone","Polydioxanone","D016687",4,0,8,0,2,0,2]
["Polyglactin 910","Polyglactin 910","D011098",67,6,69,3,25,0,2]
["Polyglycolic Acid","Polyglycolic Acid","D011100",474,20,611,18,158,0,2]
["polymeric 4,4'-diphenylmethane diisocyanate","polymeric 4,4'-diphenylmethane diisocyanate","C087867",2,0,2,0,0,0,2]
["polyurethane foam","polyurethane foam","C028279",35,0,11,2,0,0,2]
["polyvinylidene fluoride","polyvinylidene fluoride","C024865",40,0,21,2,0,0,2]
["posaconazole","posaconazole","C101425",19,1,2,0,5,1,2]
["potassium thiocyanate","potassium thiocyanate","C009941",8,0,0,0,0,0,2]
["Prilocaine","Prilocaine","D011318",45,9,0,0,2,0,2]
["propylene glycol methyl ether","propylene glycol methyl ether","C005216",0,7,0,0,0,0,2]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C580,B580)","v":"Prostaglandins D"},"Prostaglandins D","D011457",10,1,0,0,0,0,2]
["R 61837","R 61837","C057389",4,0,0,0,0,0,2]
["rhodamine B","rhodamine B","C029773",186,0,5,0,8,0,2]
["S 1 (combination)","S 1 (combination)","C079198",4,2,19,7,29,0,2]
["selamectin","selamectin","C414354",0,0,2,0,0,0,2]
["Smallpox Vaccine","Smallpox Vaccine","D012900",0,20,1,0,0,0,2]
["sodium borate","sodium borate","C010634",14,0,0,0,1,0,2]
["Sodium Hypochlorite","Sodium Hypochlorite","D012973",175,21,8,0,4,0,2]
["Sodium Salicylate","Sodium Salicylate","D012980",101,10,4,2,53,0,2]
["Sphingosine","Sphingosine","D013110",87,33,310,45,962,12,2]
["sphingosine 1-phosphate","sphingosine 1-phosphate","C060506",24,11,182,41,310,4,2]
["Squalene","Squalene","D013185",17,3,25,1,27,0,2]
["SR 140333","SR 140333","C085215",0,2,1,0,0,0,2]
["stannic oxide","stannic oxide","C045358",66,0,5,0,4,0,2]
["Succinylcholine","Succinylcholine","D013390",102,2,2,0,0,0,2]
["Sulfisomidine","Sulfisomidine","D013443",4,0,0,0,0,0,2]
["Sulfisoxazole","Sulfisoxazole","D013444",42,0,0,0,0,0,2]
["talipexole","talipexole","C024763",0,0,0,0,1,0,2]
["Tamoxifen","Tamoxifen","D013629",68,83,733,78,769,18,2]
["Technetium Tc 99m Medronate","Technetium Tc 99m Medronate","D013669",14,19,5,3,0,0,2]
["temozolomide","temozolomide","C047246",16,19,408,17,538,6,2]
["tetradecyl maltoside","tetradecyl maltoside","C459187",0,4,0,0,0,0,2]
["tetrahydrofuran","tetrahydrofuran","C018674",14,6,16,0,6,0,2]
["Thalidomide","Thalidomide","D013792",40,17,208,158,258,3,2]
["Thiamine","Thiamine","D013831",351,23,24,0,48,11,2]
["thiocyanate","thiocyanate","C031760",134,1,0,0,6,0,2]
["Thromboxane A2","Thromboxane A2","D013928",44,21,14,3,18,0,2]
["Tobramycin","Tobramycin","D014031",75,10,9,0,4,1,2]
["Trimethoprim","Trimethoprim","D014295",161,8,5,0,4,1,2]
["Vardenafil Dihydrochloride","Vardenafil Dihydrochloride","D000069058",4,2,4,0,11,0,2]
["Vinblastine","Vinblastine","D014747",67,19,117,22,196,2,2]
["Vitamin E","Vitamin E","D014810",209,123,285,30,717,15,2]
["Xylazine","Xylazine","D014991",89,5,2,0,6,0,2]
["Zanamivir","Zanamivir","D053243",0,3,0,0,0,0,2]
["Ze 339","Ze 339","C476335",0,0,0,0,0,0,2]
["1-(1,3-carboxypropyl)-4,7-carboxymethyl-1,4,7-triazacyclononane","1-(1,3-carboxypropyl)-4,7-carboxymethyl-1,4,7-triazacyclononane","C572723",0,0,0,2,0,0,1]
["10-carboxymethyl-9-acridanone","10-carboxymethyl-9-acridanone","C026430",0,4,1,0,8,0,1]
["11-dehydrosinulariolide","11-dehydrosinulariolide","C569844",0,0,4,0,10,0,1]
["13-valent pneumococcal vaccine","13-valent pneumococcal vaccine","C538862",0,2,0,0,0,0,1]
["15-keto-13,14-dihydroprostaglandin F2alpha","15-keto-13,14-dihydroprostaglandin F2alpha","C008228",4,0,0,0,0,0,1]
["2-(4-fluorophenyl)-4-(1-phenethyl-1,2,3,6-tetrahydropyridin-4-yl)-3-(pyridin-4-yl)-1H-pyrrole","2-(4-fluorophenyl)-4-(1-phenethyl-1,2,3,6-tetrahydropyridin-4-yl)-3-(pyridin-4-yl)-1H-pyrrole","C497778",0,0,0,0,0,0,1]
["2,2,4-trimethyl-1,3-pentanediol diisobutyrate","2,2,4-trimethyl-1,3-pentanediol diisobutyrate","C001508",0,0,0,0,0,0,1]
["2,4-dinitrotoluene","2,4-dinitrotoluene","C016403",12,2,1,0,0,2,1]
["2,5-dihydroxybenzoic acid","2,5-dihydroxybenzoic acid","C010925",22,1,3,0,3,0,1]
["25-hydroxyvitamin D","25-hydroxyvitamin D","C104450",5,1,21,0,10,0,1]
["2-anthramine","2-anthramine","C006593",2,0,1,0,1,2,1]
["2-diethylaminoethanol","2-diethylaminoethanol","C007369",6,1,0,0,0,0,1]
["2-isobutyl-3-methoxypyrazine","2-isobutyl-3-methoxypyrazine","C034376",4,4,0,0,0,0,1]
["2-methyl-2-butenal","2-methyl-2-butenal","C480346",2,0,0,0,0,0,1]
["2-phenylphenol","2-phenylphenol","C004369",26,0,6,0,0,0,1]
["3,4-methylenedioxypyrovalerone","3,4-methylenedioxypyrovalerone","C554666",0,2,2,0,4,0,1]
["3-chloro-2-methylprop-1-ene","3-chloro-2-methylprop-1-ene","C050660",0,0,0,0,0,0,1]
["3-methyl-2-butene-1-thiol","3-methyl-2-butene-1-thiol","C512562",0,0,0,0,0,0,1]
["4-(3-(2,4-dihydroxyphenyl)-5-(2,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide","4-(3-(2,4-dihydroxyphenyl)-5-(2,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide","C000609214",0,0,1,0,0,0,1]
["4-Butyrolactone","4-Butyrolactone","D015107",98,4,144,2,197,8,1]
["4CMenB vaccine","4CMenB vaccine","C570015",0,0,0,0,0,0,1]
["4-O-methyl-12-O-tetradecanoylphorbol 13-acetate","4-O-methyl-12-O-tetradecanoylphorbol 13-acetate","C020922",0,0,2,0,4,0,1]
["4-phenylbutyric acid","4-phenylbutyric acid","C075773",0,8,35,0,86,2,1]
["5,7,4'-trihydroxy-8-methoxyflavone","5,7,4'-trihydroxy-8-methoxyflavone","C093385",0,0,0,0,0,0,1]
["6'-(hydroxylethyl)-1-(haba)-sisomicin","6'-(hydroxylethyl)-1-(haba)-sisomicin","C550938",2,0,0,0,0,0,1]
["8-Hydroxy-2-(di-n-propylamino)tetralin","8-Hydroxy-2-(di-n-propylamino)tetralin","D017371",11,0,2,0,6,0,1]
["9-anthroic acid","9-anthroic acid","C010030",2,0,0,0,0,0,1]
["ABO Blood-Group System","ABO Blood-Group System","D000017",126,20,4,21,5,1,1]
["acetaminophen, pholcodine, pseudoephedrine drug combination","acetaminophen, pholcodine, pseudoephedrine drug combination","C041604",0,0,0,0,0,0,1]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C644,B644)","v":"Acetazolamide"},"Acetazolamide","D000086",660,8,7,4,15,0,1]
["Acid Rain","Acid Rain","D015258",405,2,0,0,0,0,1]
["Acitretin","Acitretin","D017255",0,1,8,2,15,0,1]
["Acriflavine","Acriflavine","D000167",14,3,9,2,17,1,1]
["Adapalene","Adapalene","D000068816",2,0,6,0,4,0,1]
["Adenine","Adenine","D000225",548,13,121,2,165,75,1]
["Aflatoxin B1","Aflatoxin B1","D016604",136,24,26,1,102,49,1]
["alcaligin","alcaligin","C092056",0,0,0,0,0,1,1]
["Alloxan","Alloxan","D000496",38,16,4,2,12,0,1]
["alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid","alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid","D018350",8,3,6,0,13,2,1]
["alpha-naphthoflavone","alpha-naphthoflavone","C011512",0,2,2,0,2,2,1]
["alpha-tricalcium phosphate","alpha-tricalcium phosphate","C485828",215,2,26,0,0,0,1]
["Alprenolol","Alprenolol","D000526",20,0,0,0,0,0,1]
["Aluminum Oxide","Aluminum Oxide","D000537",533,6,65,2,32,0,1]
["Amberlite XAD-2 resin","Amberlite XAD-2 resin","C003771",16,0,0,0,0,0,1]
["Amikacin","Amikacin","D000583",52,5,3,0,11,4,1]
["Aminosalicylic Acid","Aminosalicylic Acid","D010131",26,2,0,0,2,0,1]
["Amiodarone","Amiodarone","D000638",70,22,10,0,51,1,1]
["androst-16-en-3-ol","androst-16-en-3-ol","C003530",0,1,0,0,0,0,1]
["androst-16-en-3-one","androst-16-en-3-one","C000214",0,4,0,0,0,0,1]
["aniline","aniline","C023650",159,3,27,0,4,5,1]
["anthrax toxin","anthrax toxin","C030325",133,14,38,9,63,16,1]
["Antimony Sodium Gluconate","Antimony Sodium Gluconate","D000967",0,2,7,0,2,0,1]
["Antral","Antral","C091590",0,1,0,0,0,0,1]
["apaflurane","apaflurane","C094049",0,0,0,0,0,0,1]
["Apomorphine","Apomorphine","D001058",36,14,2,0,12,0,1]
["Aquamid","Aquamid","C486838",0,0,0,0,0,0,1]
["Atracurium","Atracurium","D001279",49,0,6,0,6,0,1]
["axitinib","axitinib","C503983",2,1,16,17,17,0,1]
["azapetine","azapetine","C004448",0,1,0,0,0,0,1]
["Barium Sulfate","Barium Sulfate","D001466",76,13,2,2,0,0,1]
["benazepril","benazepril","C044946",12,0,2,1,3,0,1]
["benoxinate","benoxinate","C005298",6,0,0,0,2,0,1]
["benzaldehyde","benzaldehyde","C032175",21,4,4,0,8,0,1]
["Benzoin Gum","Benzoin Gum","C457659",2,1,0,0,0,0,1]
["betadex","betadex","C031215",584,4,31,1,26,1,1]
["beta-erythroidine","beta-erythroidine","C004873",0,0,0,0,0,0,1]
["Betamethasone","Betamethasone","D001623",47,54,23,9,33,0,1]
["bis(4-hydroxycinnamoyl)methane","bis(4-hydroxycinnamoyl)methane","C034786",6,0,26,0,25,0,1]
["BMS 181885","BMS 181885","C111853",0,0,0,0,0,0,1]
["boric acid","boric acid","C032688",48,9,16,2,6,0,1]
["Bortezomib","Bortezomib","D000069286",10,14,490,40,1212,3,1]
["Bouin's solution","Bouin's solution","C026239",0,1,0,0,0,0,1]
["brequinar","brequinar","C046943",2,0,0,0,2,0,1]
["brevetoxin","brevetoxin","C053342",4,0,8,0,6,0,1]
["Brimonidine Tartrate","Brimonidine Tartrate","D000068438",12,4,2,0,6,0,1]
["Bromocriptine","Bromocriptine","D001971",6,13,14,0,40,0,1]
["Brompton mixture","Brompton mixture","C020234",0,0,0,0,0,0,1]
["Buprenorphine","Buprenorphine","D002047",55,10,4,0,17,1,1]
["Busulfan","Busulfan","D002066",26,8,31,2,66,4,1]
["butylbenzyl phthalate","butylbenzyl phthalate","C027561",14,3,12,0,10,0,1]
["Calcium Carbonate","Calcium Carbonate","D002119",816,4,48,1,20,1,1]
["Calcium Oxalate","Calcium Oxalate","D002129",330,14,5,2,31,2,1]
["caloreen","caloreen","C013862",0,0,0,0,0,0,1]
["Canola Oil","Canola Oil","D000074262",32,3,5,0,3,2,1]
["capsazepine","capsazepine","C071423",53,3,14,0,20,0,1]
["capsular polysaccharide K1","capsular polysaccharide K1","C036962",2,1,0,0,0,2,1]
["Carbimazole","Carbimazole","D002231",0,5,0,0,0,0,1]
["carbomycin","carbomycin","C059423",0,0,0,0,0,0,1]
["Carbon Disulfide","Carbon Disulfide","D002246",19,10,0,4,12,0,1]
["Carboxymethylcellulose Sodium","Carboxymethylcellulose Sodium","D002266",234,12,44,1,3,0,1]
["Carrageenan","Carrageenan","D002351",195,24,42,12,36,1,1]
["carvedilol","carvedilol","C043211",64,9,15,0,87,0,1]
["CD68 antigen, human","CD68 antigen, human","C067980",0,3,7,4,9,0,1]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C708,B708)","v":"Cefamandole"},"Cefamandole","D002435",8,0,0,0,0,0,1]
["Cefoxitin","Cefoxitin","D002440",16,1,0,0,0,0,1]
["cefprozil","cefprozil","C052018",0,0,0,0,0,0,1]
["Ceftazidime","Ceftazidime","D002442",48,1,1,0,0,2,1]
["ceftibuten","ceftibuten","C054360",25,0,0,0,0,0,1]
["ceftiofur","ceftiofur","C053503",10,1,0,0,0,0,1]
["Ceftriaxone","Ceftriaxone","D002443",42,3,5,0,10,1,1]
["Celecoxib","Celecoxib","D000068579",55,15,443,66,586,0,1]
["Cephalothin","Cephalothin","D002512",50,0,0,0,0,0,1]
["cepharanthine","cepharanthine","C006947",10,1,16,2,50,0,1]
["Chewing Gum","Chewing Gum","D002638",219,1,2,0,0,0,1]
["Chlorambucil","Chlorambucil","D002699",69,11,45,1,74,7,1]
["chlorcyclizine","chlorcyclizine","C084597",2,1,0,0,0,0,1]
["chloroethylaminouracil","chloroethylaminouracil","C006994",0,0,0,0,0,0,1]
["Cholecalciferol","Cholecalciferol","D002762",36,12,173,4,139,1,1]
["Cimetidine","Cimetidine","D002927",542,26,21,8,31,0,1]
["Clioquinol","Clioquinol","D007464",16,1,12,2,18,0,1]
["clopidogrel","clopidogrel","C055162",29,15,17,3,18,0,1]
["Coal","Coal","D003031",210,5,2,2,5,1,1]
["Cod Liver Oil","Cod Liver Oil","D003060",4,0,2,0,3,0,1]
["Colchicine","Colchicine","D003078",100,32,109,6,117,2,1]
["coproporphyrin III","coproporphyrin III","C026971",4,0,0,0,0,0,1]
["coumarin","coumarin","C030123",80,61,77,1,59,1,1]
["Cyanamide","Cyanamide","D003484",4,6,4,0,4,0,1]
["cyclopentamine","cyclopentamine","C013459",0,1,0,0,0,0,1]
["Cytochalasin D","Cytochalasin D","D015638",6,1,8,2,15,0,1]
["Dapsone","Dapsone","D003622",33,21,2,1,6,0,1]
["demethoxycurcumin","demethoxycurcumin","C050229",8,0,21,0,27,0,1]
["Deoxycholic Acid","Deoxycholic Acid","D003840",158,23,68,7,157,2,1]
["Dermatan Sulfate","Dermatan Sulfate","D003871",44,3,30,2,5,0,1]
["Dexamethasone Isonicotinate","Dexamethasone Isonicotinate","D003908",0,0,0,0,0,0,1]
["dexbrompheniramine","dexbrompheniramine","C015121",0,0,0,0,0,0,1]
["Diatrizoate","Diatrizoate","D003973",46,22,0,0,6,0,1]
["Dicloxacillin","Dicloxacillin","D004009",12,1,0,0,0,0,1]
["Dicumarol","Dicumarol","D001728",22,26,7,0,20,0,1]
["Diethylstilbestrol","Diethylstilbestrol","D004054",69,27,52,126,99,1,1]
["Digoxigenin","Digoxigenin","D004076",4,0,4,0,3,1,1]
["Digoxin","Digoxin","D004077",109,14,21,2,29,2,1]
["Dihematoporphyrin Ether","Dihematoporphyrin Ether","D017323",8,22,14,6,55,2,1]
["Dihydro-beta-Erythroidine","Dihydro-beta-Erythroidine","D004079",0,0,0,0,0,0,1]
["Dihydroergotamine","Dihydroergotamine","D004087",2,10,0,0,2,1,1]
["dihydrosafrole","dihydrosafrole","C035396",0,0,0,0,0,0,1]
["Dimethindene","Dimethindene","D004115",4,0,0,0,0,0,1]
["dimethyl methylphosphonate","dimethyl methylphosphonate","C031116",6,0,0,0,0,0,1]
["dimethyl sulfate","dimethyl sulfate","C007482",2,1,2,0,0,2,1]
["dimethyl sulfide","dimethyl sulfide","C004784",22,0,0,0,2,0,1]
["Diphtheria Toxoid","Diphtheria Toxoid","D004168",14,10,4,0,0,0,1]
["Dipyrone","Dipyrone","D004177",24,6,5,0,7,0,1]
["disialo-lacto-N-norhexaosyl ceramide","disialo-lacto-N-norhexaosyl ceramide","C045713",0,0,0,0,0,0,1]
["dithiobis(succinimidylpropionate)","dithiobis(succinimidylpropionate)","C011240",2,0,0,0,0,0,1]
["docetaxel","docetaxel","C067311",61,15,493,46,795,0,1]
["doramectin","doramectin","C084101",0,0,2,0,0,0,1]
["Doxepin","Doxepin","D004316",18,2,0,0,2,0,1]
["DryVax vaccine","DryVax vaccine","C078786",0,0,0,0,0,0,1]
["EBNA4 antigen","EBNA4 antigen","C438197",0,0,0,0,0,0,1]
["Echothiophate Iodide","Echothiophate Iodide","D004456",4,0,0,0,0,0,1]
["Emetine","Emetine","D004640",12,4,7,0,24,2,1]
["enilconazole","enilconazole","C017435",4,0,2,0,0,0,1]
["enterotoxin C, staphylococcal","enterotoxin C, staphylococcal","C034959",8,3,21,0,3,1,1]
["enterotoxin, Clostridium","enterotoxin, Clostridium","C035598",4,6,0,0,9,2,1]
["enviroxime","enviroxime","C021595",0,0,0,0,0,0,1]
["Eosine Yellowish-(YS)","Eosine Yellowish-(YS)","D004801",78,3,3,1,10,0,1]
["Epoprostenol","Epoprostenol","D011464",141,30,54,5,65,2,1]
["Ergonovine","Ergonovine","D004874",4,1,0,0,0,0,1]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C772,B772)","v":"Ergotamine"},"Ergotamine","D004878",18,19,2,0,0,1,1]
["Erlotinib Hydrochloride","Erlotinib Hydrochloride","D000069347",8,3,236,11,230,1,1]
["Ether","Ether","D004986",79,10,6,0,5,1,1]
["Ethiodized Oil","Ethiodized Oil","D004998",2,3,0,2,2,0,1]
["ethyl acetate","ethyl acetate","C007650",10,3,20,1,30,1,1]
["ethyl cellulose","ethyl cellulose","C013517",102,0,5,0,0,0,1]
["Ethylene Oxide","Ethylene Oxide","D005027",35,12,6,0,5,1,1]
["Etoposide","Etoposide","D005047",61,13,181,2,934,8,1]
["Etretinate","Etretinate","D005050",0,12,1,16,5,0,1]
["eucalyptol","eucalyptol","C010087",6,11,10,0,8,1,1]
["Fenbendazole","Fenbendazole","D005273",6,3,2,0,3,0,1]
["Fenthion","Fenthion","D005284",6,4,0,0,3,0,1]
["fenvalerate","fenvalerate","C017690",10,1,9,0,17,0,1]
["ferric chloride","ferric chloride","C024555",121,3,12,0,15,2,1]
["ferrous sulfate","ferrous sulfate","C020748",86,4,4,0,8,0,1]
["Firefly Luciferin","Firefly Luciferin","D049454",68,0,2,0,3,0,1]
["firocoxib","firocoxib","C487384",0,0,0,0,0,0,1]
["florfenicol","florfenicol","C035534",16,1,0,0,0,0,1]
["Floxacillin","Floxacillin","D005436",17,2,0,0,0,0,1]
["FluBlok","FluBlok","C528512",0,0,0,0,0,0,1]
["Flunitrazepam","Flunitrazepam","D005445",37,2,0,0,0,0,1]
["Fluoxetine","Fluoxetine","D005473",54,12,165,0,90,4,1]
["Freund's Adjuvant","Freund's Adjuvant","D005620",2,16,10,0,9,0,1]
["furan","furan","C039281",22,3,26,10,30,2,1]
["galactomannan","galactomannan","C012990",40,1,12,0,4,0,1]
["galactosaminoglycan","galactosaminoglycan","C007815",2,0,0,0,0,0,1]
["gamma-Tocopherol","gamma-Tocopherol","D024504",4,4,24,2,32,1,1]
["gastrodin","gastrodin","C045345",4,2,7,0,19,0,1]
["gatifloxacin","gatifloxacin","C078049",43,0,3,0,1,0,1]
["gefitinib","gefitinib","C419708",8,7,506,24,500,0,1]
["gelomyrtol","gelomyrtol","C016469",0,0,0,0,0,0,1]
["gentamicin A","gentamicin A","C030880",0,0,0,0,0,0,1]
["Ginkgo biloba extract","Ginkgo biloba extract","C063170",4,6,12,3,122,0,1]
["glycolide E-caprolactone copolymer","glycolide E-caprolactone copolymer","C095495",0,1,1,1,0,0,1]
["halopredone acetate","halopredone acetate","C015912",0,1,0,0,0,0,1]
["Hexobarbital","Hexobarbital","D006591",32,2,0,0,0,0,1]
["Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18","Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18","D000068857",0,0,2,0,0,0,1]
["hyaluronic acid benzyl ester","hyaluronic acid benzyl ester","C086358",0,0,1,0,0,0,1]
["Hydrobromic Acid","Hydrobromic Acid","D018054",0,1,0,0,0,0,1]
["Hydrogen Cyanide","Hydrogen Cyanide","D006856",62,0,0,0,2,0,1]
["hydroquinone","hydroquinone","C031927",95,6,41,0,86,3,1]
["Hydroxocobalamin","Hydroxocobalamin","D006879",28,2,0,0,2,0,1]
["hydroxyapatite cement","hydroxyapatite cement","C475044",2,2,4,0,0,0,1]
["hydroxyapatite-polylactide","hydroxyapatite-polylactide","C499699",2,0,4,0,0,0,1]
["hydroxydione","hydroxydione","C084598",0,0,2,0,0,0,1]
["hydroxypropylcellulose","hydroxypropylcellulose","C008079",24,2,7,0,2,0,1]
["hypothiocyanite ion","hypothiocyanite ion","C014607",30,0,0,0,2,0,1]
["Ice","Ice","D007053",68,4,1,1,1,4,1]
["Iloprost","Iloprost","D016285",12,21,11,2,13,0,1]
["Imatinib Mesylate","Imatinib Mesylate","D000068877",28,27,675,29,943,31,1]
["Indapamide","Indapamide","D007190",8,1,2,0,4,0,1]
["indole","indole","C030374",47,1,75,1,32,6,1]
["Indomethacin","Indomethacin","D007213",407,52,102,18,230,1,1]
["Inositol 1,4,5-Trisphosphate","Inositol 1,4,5-Trisphosphate","D015544",155,12,15,1,37,5,1]
["Iodized Oil","Iodized Oil","D007459",4,37,2,2,6,0,1]
["Ipecac","Ipecac","D007486",2,2,0,0,0,0,1]
["isononanoyl oxybenzene sulfonate","isononanoyl oxybenzene sulfonate","C057121",0,0,0,0,0,0,1]
["isothiocyanic acid","isothiocyanic acid","C037152",4,2,17,0,28,0,1]
["Josamycin","Josamycin","D015570",10,2,2,1,2,0,1]
["Juvéderm","Juvéderm","C527044",0,0,0,0,0,0,1]
["kakkon-to","kakkon-to","C090831",0,0,0,0,0,0,1]
["Kerosene","Kerosene","D007648",12,1,2,0,2,0,1]
["Ketoprofen","Ketoprofen","D007660",211,2,10,5,9,1,1]
["Ketotifen","Ketotifen","D007665",14,7,2,1,2,0,1]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C836,B836)","v":"Kitasamycin"},"Kitasamycin","D015939",0,0,2,0,0,0,1]
["Kloroperka","Kloroperka","C029585",0,0,0,0,0,0,1]
["KOB03","KOB03","C585464",0,1,0,0,0,0,1]
["lamotrigine","lamotrigine","C047781",20,8,8,0,15,0,1]
["Latex","Latex","D007840",165,6,24,3,14,0,1]
["Lavsan","Lavsan","C025539",0,2,0,0,0,0,1]
["Leukotriene B4","Leukotriene B4","D007975",42,14,26,1,29,0,1]
["Levamisole","Levamisole","D007978",22,51,5,3,8,1,1]
["Levonorgestrel","Levonorgestrel","D016912",5,10,20,10,21,0,1]
["Levorphanol","Levorphanol","D007981",8,1,0,0,0,0,1]
["Lewis X Antigen","Lewis X Antigen","D016256",8,3,24,5,16,3,1]
["lime","lime","C016538",282,3,7,0,0,0,1]
["Linezolid","Linezolid","D000069349",12,4,4,0,6,3,1]
["Linoleic Acid","Linoleic Acid","D019787",126,10,39,4,70,2,1]
["liposomal amphotericin B","liposomal amphotericin B","C068538",0,2,7,0,5,0,1]
["lornoxicam","lornoxicam","C059451",22,0,0,0,2,0,1]
["Lugol's solution","Lugol's solution","C010389",4,2,0,0,2,0,1]
["Lutrol F 127","Lutrol F 127","C510078",4,4,0,0,0,0,1]
["Mannomustine","Mannomustine","D008357",0,0,0,0,0,0,1]
["marbofloxacin","marbofloxacin","C080260",4,1,0,0,0,0,1]
["Materia Medica","Materia Medica","D008419",28,2,78,3,64,0,1]
["Mechlorethamine","Mechlorethamine","D008466",38,17,26,0,47,7,1]
["Mefloquine","Mefloquine","D015767",36,0,8,0,19,2,1]
["Menhaden oil","Menhaden oil","C033266",2,4,2,0,4,0,1]
["Mepivacaine","Mepivacaine","D008619",73,4,0,0,4,0,1]
["Meprobamate","Meprobamate","D008620",14,0,0,0,0,0,1]
["Methamphetamine","Methamphetamine","D008694",101,27,38,1,204,3,1]
["Methane","Methane","D008697",966,2,76,1,52,2,1]
["Methoxyflurane","Methoxyflurane","D008733",205,14,0,0,0,0,1]
["methyl acrylate","methyl acrylate","C035956",6,0,2,0,0,0,1]
["Methyl Green","Methyl Green","D008739",10,1,0,0,3,0,1]
["methyl tert-butyl ether","methyl tert-butyl ether","C043243",40,2,4,0,4,1,1]
["Methylcellulose","Methylcellulose","D008747",360,7,13,3,2,0,1]
["Methylcholanthrene","Methylcholanthrene","D008748",36,14,21,41,12,1,1]
["methylprednisolone acetate","methylprednisolone acetate","C000873",2,7,0,2,4,0,1]
["Metoprolol","Metoprolol","D008790",89,4,4,1,29,0,1]
["Metyrapone","Metyrapone","D008797",14,21,3,4,1,0,1]
["milbemycin oxime","milbemycin oxime","C078973",0,0,0,0,0,2,1]
["Milrinone","Milrinone","D020105",29,2,0,0,7,0,1]
["Mineral Oil","Mineral Oil","D008899",20,9,2,0,4,0,1]
["mivacurium","mivacurium","C049430",0,0,0,0,2,0,1]
["modafinil","modafinil","C048833",2,0,4,0,2,0,1]
["Mollomed","Mollomed","C027899",0,0,0,0,0,0,1]
["mono-isobutyl phthalate","mono-isobutyl phthalate","C575690",0,0,0,0,0,0,1]
["monomethoxypolyethyleneglycol-polylactide block copolymer","monomethoxypolyethyleneglycol-polylactide block copolymer","C542623",8,0,20,1,14,0,1]
["monooctanoin","monooctanoin","C025343",4,2,0,0,0,0,1]
["moxifloxacin","moxifloxacin","C104727",36,0,7,0,1,1,1]
["Mycophenolic Acid","Mycophenolic Acid","D009173",46,21,191,9,144,5,1]
["N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide","N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide","C063509",10,0,6,4,64,5,1]
["NanoGel","NanoGel","C413692",146,2,36,2,34,0,1]
["naphtha","naphtha","C004544",2,5,2,0,2,0,1]
["naratriptan","naratriptan","C106783",6,0,0,0,0,0,1]
["Naseptin","Naseptin","C070815",0,1,0,0,0,0,1]
["n-butoxyethanol","n-butoxyethanol","C017096",2,7,2,0,6,1,1]
["n-butyl acrylate","n-butyl acrylate","C032490",8,0,2,0,0,0,1]
["neomycin sulfate, pyridine carboxylate of dexamethasone, tyzanol drug combination","neomycin sulfate, pyridine carboxylate of dexamethasone, tyzanol drug combination","C000886",0,0,0,0,0,0,1]
["Neostigmine","Neostigmine","D009388",59,3,0,0,0,0,1]
["Nifedipine","Nifedipine","D009543",138,23,39,1,67,1,1]
["nitinol","nitinol","C013616",12,5,19,0,2,0,1]
["Nitric Acid","Nitric Acid","D017942",44,3,1,4,4,0,1]
["Nitrofurazone","Nitrofurazone","D009583",19,12,4,0,2,3,1]
["Nitroglycerin","Nitroglycerin","D005996",75,36,9,1,13,2,1]
["nitrosoazetidine","nitrosoazetidine","C005145",0,0,0,0,0,0,1]
["N-nitroso-(2,2,2-trifluoroethyl)ethylamine","N-nitroso-(2,2,2-trifluoroethyl)ethylamine","C038526",0,1,0,0,0,0,1]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C900,B900)","v":"N-nitroso-1,3-oxazolidine"},"N-nitroso-1,3-oxazolidine","C035920",0,0,0,0,0,0,1]
["N-nitroso-5-methyl-1,3-oxazolidine","N-nitroso-5-methyl-1,3-oxazolidine","C027753",0,0,0,0,0,0,1]
["N-nitrosomorpholine","N-nitrosomorpholine","C002741",26,5,0,0,6,4,1]
["Norethindrone","Norethindrone","D009640",27,19,22,2,16,0,1]
["norethindrone acetate","norethindrone acetate","C024262",7,2,4,0,5,0,1]
["Nystatin","Nystatin","D009761",78,3,0,1,2,4,1]
["octamethylcyclotetrasiloxane","octamethylcyclotetrasiloxane","C024064",2,0,0,0,0,0,1]
["octenidine","octenidine","C034213",2,11,8,0,0,0,1]
["octyl 2-cyanoacrylate","octyl 2-cyanoacrylate","C100832",2,2,5,0,0,0,1]
["olanzapine","olanzapine","C076029",26,9,24,2,24,0,1]
["Olive Oil","Olive Oil","D000069463",166,2,46,2,71,2,1]
["o-Phthalaldehyde","o-Phthalaldehyde","D009764",76,0,2,0,0,0,1]
["Oxycodone","Oxycodone","D010098",18,4,0,0,0,0,1]
["oxycodone-acetaminophen","oxycodone-acetaminophen","C514822",0,3,0,0,0,0,1]
["paladon","paladon","C024149",0,0,0,0,0,0,1]
["Paliperidone Palmitate","Paliperidone Palmitate","D000068882",8,4,2,1,2,0,1]
["Paspat","Paspat","C038593",0,0,0,0,0,0,1]
["Pefloxacin","Pefloxacin","D015366",24,1,0,2,3,1,1]
["Penicillin G Benzathine","Penicillin G Benzathine","D010401",4,9,0,0,0,0,1]
["Pentobarbital","Pentobarbital","D010424",230,17,2,0,9,0,1]
["peramivir","peramivir","C414210",0,0,0,0,0,1,1]
["Pertussis Vaccine","Pertussis Vaccine","D010567",8,13,10,0,1,2,1]
["Phenobarbital","Phenobarbital","D010634",249,42,39,0,49,5,1]
["Phentolamine","Phentolamine","D010646",45,20,3,1,3,0,1]
["Phenylbutazone","Phenylbutazone","D010653",91,24,0,1,2,0,1]
["Phloretin","Phloretin","D010693",36,1,20,0,41,0,1]
["Phosgene","Phosgene","D010705",7,0,0,0,6,0,1]
["phosphoric acid","phosphoric acid","C030242",90,1,7,0,0,0,1]
["phthalic acid","phthalic acid","C032279",68,0,8,0,10,0,1]
["Physiomer","Physiomer","C448784",0,3,0,2,0,0,1]
["Picibanil","Picibanil","D010844",2,5,7,0,12,0,1]
["Pimozide","Pimozide","D010868",0,2,12,0,10,0,1]
["piperonal","piperonal","C005454",0,1,0,0,0,0,1]
["PL 732","PL 732","C035051",22,0,0,0,0,0,1]
["pleconaril","pleconaril","C115201",0,0,0,0,0,0,1]
["p-Methoxy-N-methylphenethylamine","p-Methoxy-N-methylphenethylamine","D003189",37,8,2,1,0,0,1]
["Pneumabort-K","Pneumabort-K","C076173",0,0,0,0,0,0,1]
["polihexanide","polihexanide","C031233",9,4,11,0,2,0,1]
["Poliovirus Vaccine, Inactivated","Poliovirus Vaccine, Inactivated","D011054",0,2,0,0,0,0,1]
["Poliovirus Vaccine, Oral","Poliovirus Vaccine, Oral","D011055",10,6,1,0,1,3,1]
["poly(lactide)","poly(lactide)","C033616",189,8,247,2,21,0,1]
["polycaprolactone","polycaprolactone","C016240",170,5,629,5,37,0,1]
["Polyethyleneimine","Polyethyleneimine","D011094",568,9,147,10,148,1,1]
["poly-N-isopropylacrylamide","poly-N-isopropylacrylamide","C052970",140,0,34,0,8,0,1]
["polypyrrole","polypyrrole","C067635",146,2,47,1,3,0,1]
["polytetrafluoroethane","polytetrafluoroethane","C010946",0,1,0,0,0,0,1]
["polyvinyl acetal","polyvinyl acetal","C104919",0,1,0,0,0,0,1]
["polyvinyl acetate","polyvinyl acetate","C013215",14,0,2,0,0,0,1]
["poractant alfa","poractant alfa","C068291",10,0,0,0,6,0,1]
["Potassium Chloride","Potassium Chloride","D011189",378,18,2,0,22,4,1]
["Praziquantel","Praziquantel","D011223",16,3,7,0,10,1,1]
["prednazoline","prednazoline","C042176",0,1,0,0,0,0,1]
["Prochlorperazine","Prochlorperazine","D011346",6,3,0,0,0,0,1]
["Promethazine","Promethazine","D011398",66,24,0,0,0,0,1]
["Proplast","Proplast","D011428",0,0,0,1,0,0,1]
["proplast II","proplast II","C036587",0,0,0,1,0,0,1]
["pumice","pumice","C005144",16,0,0,0,0,0,1]
["pycnogenols","pycnogenols","C024070",2,0,4,0,24,0,1]
["pyridine","pyridine","C023666",106,7,70,1,47,0,1]
["Pyrilamine","Pyrilamine","D011738",8,1,0,0,0,0,1]
["pyropheophorbide a","pyropheophorbide a","C040298",6,0,2,0,4,0,1]
["pyrrobutamine","pyrrobutamine","C013665",0,0,0,0,0,0,1]
["Quinacrine","Quinacrine","D011796",72,14,23,6,47,0,1]
["Quinine","Quinine","D011803",103,13,4,0,9,1,1]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C964,B964)","v":"Remoxipride"},"Remoxipride","D017330",2,0,0,0,6,0,1]
["REP8839","REP8839","C533960",0,2,0,0,0,0,1]
["Reston","Reston","C030534",0,0,0,0,0,0,1]
["resveratrol","resveratrol","C059514",94,35,1086,31,1815,8,1]
["RFI 641","RFI 641","C434804",0,0,0,0,0,0,1]
["rhin A.T.P.","rhin A.T.P.","C030165",0,0,0,0,0,0,1]
["Rifaprim","Rifaprim","C020800",0,0,0,0,0,0,1]
["Rivastigmine","Rivastigmine","D000068836",8,6,0,0,1,0,1]
["roridin L","roridin L","C447461",0,0,0,0,0,0,1]
["Ruthenium Red","Ruthenium Red","D012430",24,6,0,0,6,0,1]
["Safrole","Safrole","D012451",8,0,8,0,32,0,1]
["Salicylic Acid","Salicylic Acid","D020156",269,6,41,1,59,3,1]
["Salmeterol Xinafoate","Salmeterol Xinafoate","D000068299",14,7,3,1,10,0,1]
["saprisartan potassium","saprisartan potassium","C089586",0,1,0,0,0,0,1]
["SDZ 249-665","SDZ 249-665","C425286",0,0,0,0,0,0,1]
["SEIM enterotoxin, Staphylococcus aureus","SEIM enterotoxin, Staphylococcus aureus","C495715",0,0,1,0,0,0,1]
["SEIO enterotoxin, Staphylococcus aureus","SEIO enterotoxin, Staphylococcus aureus","C495716",0,0,1,0,0,0,1]
["Selenious Acid","Selenious Acid","D020887",44,5,19,0,34,0,1]
["Semustine","Semustine","D012673",0,0,0,0,0,0,1]
["sesamol","sesamol","C025583",4,0,2,0,31,0,1]
["Sewage","Sewage","D012722",3166,2,37,0,6,4,1]
["sho-seiryu-to","sho-seiryu-to","C090832",0,5,3,0,2,0,1]
["shuang-huang-lian","shuang-huang-lian","C516400",2,0,0,0,0,0,1]
["sialosyl-Tn antigen","sialosyl-Tn antigen","C055491",4,0,5,16,4,0,1]
["sibutramine","sibutramine","C058254",4,0,0,0,2,0,1]
["Silver Nitrate","Silver Nitrate","D012835",44,18,6,1,13,1,1]
["Silver Sulfadiazine","Silver Sulfadiazine","D012837",8,3,10,1,0,0,1]
["Sinupret","Sinupret","C028353",0,8,0,0,0,0,1]
["Sisomicin","Sisomicin","D012853",28,2,0,0,0,1,1]
["Snap (resin)","Snap (resin)","C091347",2,0,0,0,0,0,1]
["Sodium Benzoate","Sodium Benzoate","D020160",16,1,2,0,0,0,1]
["sodium nitrate","sodium nitrate","C031618",16,0,2,0,4,0,1]
["Sodium Pertechnetate Tc 99m","Sodium Pertechnetate Tc 99m","D013670",16,3,1,0,3,0,1]
["Soil","Soil","D012987",4331,3,13,2,1,3,1]
["Soot","Soot","D053260",38,2,14,0,8,1,1]
["sorbsan","sorbsan","C078112",0,0,0,0,0,0,1]
["sparfloxacin","sparfloxacin","C061363",32,0,2,0,4,0,1]
["sphingosine phosphorylcholine","sphingosine phosphorylcholine","C005356",8,1,14,0,22,0,1]
["stachyflin","stachyflin","C120519",0,0,2,0,0,0,1]
["stachyflin III","stachyflin III","C421362",0,0,0,0,0,0,1]
["stachyflin III, phosphate ester","stachyflin III, phosphate ester","C421364",0,0,0,0,0,0,1]
["Strychnine","Strychnine","D013331",52,5,19,2,19,1,1]
["succinylsulfanilamide","succinylsulfanilamide","C030166",0,0,0,0,0,0,1]
["Sudan Black B","Sudan Black B","C016118",2,1,0,0,0,0,1]
["Sulfadiazine","Sulfadiazine","D013411",76,6,0,0,0,0,1]
["Sulfamethoxazole","Sulfamethoxazole","D013420",136,3,9,1,2,3,1]
["Sulfamoxole","Sulfamoxole","D013423",0,0,0,0,0,0,1]
["sulfathiazole","sulfathiazole","C005312",12,1,0,0,1,1,1]
["superoxidized water","superoxidized water","C118085",34,3,0,0,4,0,1]
["T-2 Toxin","T-2 Toxin","D013605",21,29,28,0,124,1,1]
["Tacrine","Tacrine","D013619",25,8,12,0,37,1,1]
["tanshinone","tanshinone","C021751",18,0,218,6,339,0,1]
["Tea Tree Oil","Tea Tree Oil","D020947",8,2,4,0,2,0,1]
["Technetium Tc 99m Exametazime","Technetium Tc 99m Exametazime","D019690",8,11,2,0,6,0,1]
["Technetium Tc 99m Pentetate","Technetium Tc 99m Pentetate","D016284",2,7,0,2,1,0,1]
["temoporfin","temoporfin","C072269",16,19,7,0,38,0,1]
["terephthalic acid","terephthalic acid","C011363",28,0,3,0,2,0,1]
["tertiary-amyl methyl ether","tertiary-amyl methyl ether","C096680",2,3,0,0,0,0,1]
["Tetrabenazine","Tetrabenazine","D013747",14,0,2,0,0,0,1]
["Tetradecanoylphorbol Acetate","Tetradecanoylphorbol Acetate","D013755",176,14,147,12,313,20,1]
["Theophylline","Theophylline","D013806",508,23,10,4,57,0,1]
["Thiamphenicol","Thiamphenicol","D013839",26,2,0,0,2,0,1]
["Thiopental","Thiopental","D013874",224,14,0,0,13,0,1]
["Thromboxane B2","Thromboxane B2","D013929",28,9,0,0,2,0,1]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C1028,B1028)","v":"Ticlopidine"},"Ticlopidine","D013988",35,18,19,3,20,0,1]
["Timolol","Timolol","D013999",60,8,8,0,11,0,1]
["toceranib phosphate","toceranib phosphate","C464577",0,0,0,0,4,0,1]
["Toluene 2,4-Diisocyanate","Toluene 2,4-Diisocyanate","D014051",2,19,6,0,0,0,1]
["Triad resin","Triad resin","C060386",2,0,0,0,0,0,1]
["Triaziquone","Triaziquone","D014228",4,3,0,0,2,1,1]
["Trichloroacetic Acid","Trichloroacetic Acid","D014238",50,17,5,2,9,0,1]
["trichrome stain","trichrome stain","C017768",2,1,0,0,1,0,1]
["Triclosan","Triclosan","D014260",115,0,34,0,27,0,1]
["Triprolidine","Triprolidine","D014311",8,3,0,0,0,0,1]
["Tuberculin","Tuberculin","D014373",28,6,6,0,5,1,1]
["UH 301","UH 301","C064282",0,0,0,0,0,0,1]
["Uracil Mustard","Uracil Mustard","D014499",0,0,0,0,0,0,1]
["Uric Acid","Uric Acid","D014527",842,30,26,2,46,0,1]
["Ursodeoxycholic Acid","Ursodeoxycholic Acid","D014580",49,13,44,0,180,0,1]
["Valproic Acid","Valproic Acid","D014635",71,64,426,15,511,2,1]
["vanadium pentoxide","vanadium pentoxide","C066075",8,3,7,2,12,2,1]
["vemurafenib","vemurafenib","C551177",2,3,127,13,74,0,1]
["Verapamil","Verapamil","D014700",248,45,43,2,79,3,1]
["verteporfin","verteporfin","C098350",0,10,30,31,38,0,1]
["vinyl polysiloxane","vinyl polysiloxane","C034183",2,0,2,0,0,0,1]
["Vitallium","Vitallium","D014800",6,2,4,0,3,0,1]
["Vitamin K","Vitamin K","D014812",127,23,26,0,64,8,1]
["whitlockite","whitlockite","C021767",6,1,0,0,0,0,1]
["WP1066","WP1066","C519885",0,0,21,2,19,0,1]
["xingnaojing","xingnaojing","C000594497",0,2,0,0,2,0,1]
["Xylose","Xylose","D014994",242,9,23,0,4,15,1]
["Y 27632","Y 27632","C108830",2,1,100,1,68,0,1]
["Yellow Fever Vaccine","Yellow Fever Vaccine","D022341",0,0,5,0,1,0,1]
["zinc chloride","zinc chloride","C016837",88,5,15,0,44,0,1]
["zinc hematoporphyrin","zinc hematoporphyrin","C017802",0,0,0,1,2,0,1]
["Zinc Oxide","Zinc Oxide","D015034",358,25,105,0,167,3,1]
["(((4-(ethoxycarbonyl)phenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methan-1-one","(((4-(ethoxycarbonyl)phenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methan-1-one","C508274",0,0,2,0,1,0,0]
["(((4-(ethoxycarbonyl)phenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methane-1-thione","(((4-(ethoxycarbonyl)phenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methane-1-thione","C508275",0,0,2,0,1,0,0]
["(((4-nitrophenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methane-1-thione","(((4-nitrophenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methane-1-thione","C476105",0,0,8,2,13,0,0]
["((-)-7-(3-amino-1-azetidinyl)-8-chloro-1-cyclopropyl-1,4-dihydro-6-fluoro-4-oxo-3-quinolinecarboxylic acid)","((-)-7-(3-amino-1-azetidinyl)-8-chloro-1-cyclopropyl-1,4-dihydro-6-fluoro-4-oxo-3-quinolinecarboxylic acid)","C444451",2,0,0,0,0,0,0]
["((-)-7-(3-amino-2-methyl-1-azetidinyl)-8-chloro-1-cyclopropyl-1,4-dihydro-6-fluoro-4-oxo-3-quinolinecarboxylic acid)","((-)-7-(3-amino-2-methyl-1-azetidinyl)-8-chloro-1-cyclopropyl-1,4-dihydro-6-fluoro-4-oxo-3-quinolinecarboxylic acid)","C444450",2,0,0,0,0,0,0]
["((1R,2R)-1,2-diaminocyclohexane)platinum(II)","((1R,2R)-1,2-diaminocyclohexane)platinum(II)","C554217",2,0,2,0,0,0,0]
["((1S)-1-((((1S)-1-benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl)-3-methylbutyl)carbamic acid 5-methoxy-3-oxapentyl ester","((1S)-1-((((1S)-1-benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl)-3-methylbutyl)carbamic acid 5-methoxy-3-oxapentyl ester","C515164",0,0,2,0,4,0,0]
["((2,3,7,8,12,13,17,18-octakis(benzylthio)-5,10,15,20-tetraazaporphyrin))nickel(II)","((2,3,7,8,12,13,17,18-octakis(benzylthio)-5,10,15,20-tetraazaporphyrin))nickel(II)","C488536",2,0,0,0,0,0,0]
["((2,6-bis(1-methylethyl)phenoxy)sulfonyl)carbamic acid 2,6-bis(1-methylethyl)phenyl ester","((2,6-bis(1-methylethyl)phenoxy)sulfonyl)carbamic acid 2,6-bis(1-methylethyl)phenyl ester","C086204",2,0,0,0,0,0,0]
["((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)","((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)","C478479",0,0,20,0,14,0,0]
["((5-nitrofuran-2-yl)methyl-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenyl 4-chlorobutyl(methyl)phosphoramidate)","((5-nitrofuran-2-yl)methyl-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenyl 4-chlorobutyl(methyl)phosphoramidate)","C548776",0,0,2,0,1,0,0]
["((5Z)5-(1,3-benzodioxol-5-yl)methylene-2-phenylamino-3,5-dihydro-4H-imidazol-4-one)","((5Z)5-(1,3-benzodioxol-5-yl)methylene-2-phenylamino-3,5-dihydro-4H-imidazol-4-one)","C578491",0,0,0,0,2,0,0]
["((7-chloroquinolin-4-yl)amino)chalcone","((7-chloroquinolin-4-yl)amino)chalcone","C587511",0,0,2,0,0,0,0]
["((diethylenetriamine)copper(II)(mu-imidazolate)copper(II)(diethylenetriamine)) perchlorate","((diethylenetriamine)copper(II)(mu-imidazolate)copper(II)(diethylenetriamine)) perchlorate","C500449",2,0,0,0,0,0,0]
["((dihydroindenyl)oxy)alkanoic acid","((dihydroindenyl)oxy)alkanoic acid","C059990",2,0,0,0,0,0,0]
["((E)-(5)-(3,5-di-tert-butyl-4-hydroxybenzylidene)- 2-ethyl-1,2-isothiazolidine-1,1-dioxide)","((E)-(5)-(3,5-di-tert-butyl-4-hydroxybenzylidene)- 2-ethyl-1,2-isothiazolidine-1,1-dioxide)","C409872",0,0,0,0,2,0,0]
["((eta6-p-cymene)Ru(4,4,4-trifluoro-1-(4-chlorophenyl)-1,3-butanedione)-1,3,5-triaza-7-phosphaadamantane)","((eta6-p-cymene)Ru(4,4,4-trifluoro-1-(4-chlorophenyl)-1,3-butanedione)-1,3,5-triaza-7-phosphaadamantane)","C000599960",0,0,0,0,2,0,0]
["((H2O)(terpy)Mn(mu-O)2Mn(terpy)(OH2))(NO3)3","((H2O)(terpy)Mn(mu-O)2Mn(terpy)(OH2))(NO3)3","C550429",2,0,0,0,0,0,0]
["((N-morpholine)metylene)daunorubicin","((N-morpholine)metylene)daunorubicin","C561665",4,0,0,0,0,0,0]
["((N-piperidine)methylene)daunorubicin hydrochloride","((N-piperidine)methylene)daunorubicin hydrochloride","C000592427",2,0,0,0,0,0,0]
["((Py-3')TPP-Ru(phen)2Cl)Cl","((Py-3')TPP-Ru(phen)2Cl)Cl","C547322",0,0,0,0,1,0,0]
["((S)-2-acetylamino-3-((R)-(1-(3-(piperidin-4-yl)propionyl)piperidin-3-ylcarbonyl))amino) propionic acid trihydrate","((S)-2-acetylamino-3-((R)-(1-(3-(piperidin-4-yl)propionyl)piperidin-3-ylcarbonyl))amino) propionic acid trihydrate","C496616",0,0,0,0,2,0,0]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695",0,1,101,2,70,0,0]
["(1-(2-(5-(N,N-dimethylamino)naphthalenesulfonamido)ethyl)-1,4,7,10-tetraazacyclododecane)zinc(II)","(1-(2-(5-(N,N-dimethylamino)naphthalenesulfonamido)ethyl)-1,4,7,10-tetraazacyclododecane)zinc(II)","C473936",0,0,0,0,1,0,0]
["(1-(3-aminophenyl)-1H-pyrrol-3-yl)(3,4,5-trimethoxyphenyl)methanone","(1-(3-aminophenyl)-1H-pyrrol-3-yl)(3,4,5-trimethoxyphenyl)methanone","C000594994",0,0,2,0,0,0,0]
["(1-(4-((4-methoxybenzyl)amino)quinazolin-2-yl)piperidin-2-yl)methanol","(1-(4-((4-methoxybenzyl)amino)quinazolin-2-yl)piperidin-2-yl)methanol","C000621119",0,0,0,0,1,0,0]
["(1-(4-fluorophenyl)-4a-methyl-5,6,7,8-tetrahydro-4H-benzo(f)indazol-5-yl)-(4-(trifluoromethyl)phenyl)methanol","(1-(4-fluorophenyl)-4a-methyl-5,6,7,8-tetrahydro-4H-benzo(f)indazol-5-yl)-(4-(trifluoromethyl)phenyl)methanol","C548783",0,0,2,0,0,0,0]
["(1,10-phenanthroline)(2-phthalic acid)lanthanum(III)","(1,10-phenanthroline)(2-phthalic acid)lanthanum(III)","C510633",2,0,0,0,0,0,0]
["(1,2,4)triazolo(1,5-a)pyridinylpyridine","(1,2,4)triazolo(1,5-a)pyridinylpyridine","C587479",0,0,2,0,0,0,0]
["(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane","(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane","C478160",0,0,22,0,20,0,0]
["(1,2-bis(2, 6-difluoro-3-hydroxyphenyl)ethylene-diamine)platinum(II)","(1,2-bis(2, 6-difluoro-3-hydroxyphenyl)ethylene-diamine)platinum(II)","C488612",0,0,0,0,2,0,0]
["(1,2-bis(6-methoxy-2H-chromen-3-yl)methylene)hydrazine","(1,2-bis(6-methoxy-2H-chromen-3-yl)methylene)hydrazine","C000596021",0,0,2,0,0,0,0]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C1092,B1092)","v":"(1,2-di(cyclopentadienyl)-1,2-di(3-dimethoxyphenyl)ethanediyl)titanium dichloride"},"(1,2-di(cyclopentadienyl)-1,2-di(3-dimethoxyphenyl)ethanediyl)titanium dichloride","C507877",0,0,4,0,2,0,0]
["(1,2-di(cyclopentadienyl)-1,2-di(4-N,N-dimethylaminophenyl)ethanediyl)titanium dichloride","(1,2-di(cyclopentadienyl)-1,2-di(4-N,N-dimethylaminophenyl)ethanediyl)titanium dichloride","C507876",0,0,3,0,0,0,0]
["(1,2-diamino-4-nitrobenzene)dichloroplatinum(II)","(1,2-diamino-4-nitrobenzene)dichloroplatinum(II)","C052444",2,0,0,0,0,0,0]
["(1,2-diaminocyclohexane)(5,6-dimethyl-1,10-phenanthroline)platinum(II)","(1,2-diaminocyclohexane)(5,6-dimethyl-1,10-phenanthroline)platinum(II)","C539772",0,0,0,0,1,0,0]
["(1,3,5-triaminocyclohexane)copper(II)","(1,3,5-triaminocyclohexane)copper(II)","C472375",2,0,0,0,0,0,0]
["(1,4,7)triazecan-9-ol","(1,4,7)triazecan-9-ol","C492882",2,0,0,0,2,0,0]
["(1,4,7,10-tetrakis((N-(1H-imidazol-2-yl)carbamoyl)methyl)-1,4,7,10-tetraazacyclododecane)thulium(III)","(1,4,7,10-tetrakis((N-(1H-imidazol-2-yl)carbamoyl)methyl)-1,4,7,10-tetraazacyclododecane)thulium(III)","C533989",2,0,0,0,0,0,0]
["(1,4,7-triazacyclodecane)platinum(II)","(1,4,7-triazacyclodecane)platinum(II)","C543510",0,0,2,0,0,0,0]
["(1,8-dimethyl-1,3,6,8,10,13-hexaazacyclotetradecane)nickel(II)","(1,8-dimethyl-1,3,6,8,10,13-hexaazacyclotetradecane)nickel(II)","C573701",2,0,0,0,0,0,0]
["(10)-dehydrogingerdione","(10)-dehydrogingerdione","C561631",0,0,3,0,0,0,0]
["(10)-gingerdiol","(10)-gingerdiol","C000589423",0,0,0,0,2,0,0]
["(10)-shogaol","(10)-shogaol","C585130",0,0,2,0,0,0,0]
["(10-methyl-9-anthryl)methyl imidothiocarbamate","(10-methyl-9-anthryl)methyl imidothiocarbamate","C568282",0,0,2,0,2,0,0]
["(11aS)-8-hydroxy-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo(2,1-c)(1,4)benzodiazepin-5-one","(11aS)-8-hydroxy-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo(2,1-c)(1,4)benzodiazepin-5-one","C474072",3,0,2,0,5,0,0]
["(13-(2-(butylamino)-2-oxoacetamido)tridec-8(Z)-enoic acid)","(13-(2-(butylamino)-2-oxoacetamido)tridec-8(Z)-enoic acid)","C558112",0,0,0,0,2,0,0]
["(13-(3-propylureido)tridec-8-enoic acid)","(13-(3-propylureido)tridec-8-enoic acid)","C558111",0,0,0,0,2,0,0]
["(13aS)-deoxytylophorinine","(13aS)-deoxytylophorinine","C569808",0,0,0,0,2,0,0]
["(14E,18E,22E,26E)-methyl nonacosa-14,18,22,26 tetraenoate","(14E,18E,22E,26E)-methyl nonacosa-14,18,22,26 tetraenoate","C000602013",0,0,2,0,2,0,0]
["(1-6)-alpha-glucomannan","(1-6)-alpha-glucomannan","C022901",64,0,5,0,4,0,0]
["(16-mercapto)hexadecanoic acid (2-chlorophenyl)diphenylmethyl ester","(16-mercapto)hexadecanoic acid (2-chlorophenyl)diphenylmethyl ester","C470761",2,0,0,0,0,0,0]
["(18)F-ICMT11","(18)F-ICMT11","C571272",0,0,0,0,4,0,0]
["(19Z)-halichondramide","(19Z)-halichondramide","C495172",0,0,2,0,0,0,0]
["(1alpha,2alpha,8beta,9beta)-1,8-bis(acetyloxy)-2,9-bis(benzoyloxy)-14-hydroxy-beta-dihydroagarofuran","(1alpha,2alpha,8beta,9beta)-1,8-bis(acetyloxy)-2,9-bis(benzoyloxy)-14-hydroxy-beta-dihydroagarofuran","C587585",0,0,2,0,2,0,0]
["(1-chloroethenyl)oxirane","(1-chloroethenyl)oxirane","C439367",2,0,0,0,0,0,0]
["(1E)-1-((pyridin-2-yl)methyleneamino)-3-(3-(pyridin-2-yl)imidazo(1,5-a)pyridin-2(3H)-yl)propan-2-ol","(1E)-1-((pyridin-2-yl)methyleneamino)-3-(3-(pyridin-2-yl)imidazo(1,5-a)pyridin-2(3H)-yl)propan-2-ol","C560104",0,0,0,0,1,0,0]
["(1E,4E)-1,5-bis(2-methoxyphenyl)penta-1,4-dien-3-one","(1E,4E)-1,5-bis(2-methoxyphenyl)penta-1,4-dien-3-one","C571782",0,0,0,0,2,0,0]
["(1-ferrocenyl-4,4,4-trifluoro-1,3-butanedionat-k2O,O')rhodium(I)","(1-ferrocenyl-4,4,4-trifluoro-1,3-butanedionat-k2O,O')rhodium(I)","C487804",0,0,0,0,2,0,0]
["(1-methylene-(4-nitrophenol)-1,4,7,10-tetraazacyclododecane-4,7,10-triacetamide)gadolinium(III)","(1-methylene-(4-nitrophenol)-1,4,7,10-tetraazacyclododecane-4,7,10-triacetamide)gadolinium(III)","C492702",2,0,0,0,0,0,0]
["(1-methylene-(4-nitrophenol)-1,4,7,10-tetraazacyclododecane-4,7,10-triacetate)gadolinium(III)","(1-methylene-(4-nitrophenol)-1,4,7,10-tetraazacyclododecane-4,7,10-triacetate)gadolinium(III)","C492701",2,0,0,0,0,0,0]
["(1-O-octadecyl-2-O-(2'-deoxy-2'-aminoglucopyranosyl)glycerol(3))phosphorylcholine","(1-O-octadecyl-2-O-(2'-deoxy-2'-aminoglucopyranosyl)glycerol(3))phosphorylcholine","C505983",0,0,2,0,0,0,0]
["(1-O-octadecyl-2-O-(2'-deoxy-2'-dimethylmaleimidoglucopyranosyl)glycerol(3))phosphorylcholine","(1-O-octadecyl-2-O-(2'-deoxy-2'-dimethylmaleimidoglucopyranosyl)glycerol(3))phosphorylcholine","C505984",0,0,2,0,0,0,0]
["(1-oxyl-2,2,5,5-tetramethylpyrroline-3-methyl)methanethiosulfonate","(1-oxyl-2,2,5,5-tetramethylpyrroline-3-methyl)methanethiosulfonate","C034248",2,0,0,0,0,0,0]
["(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester","(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester","C021279",4,0,0,0,0,0,0]
["(1R,2S)-(-)-N-dodecyl-N-methylephedrinium bromide","(1R,2S)-(-)-N-dodecyl-N-methylephedrinium bromide","C514924",2,0,0,0,0,0,0]
["(1r,4r)-4-amino-N-(3,5-bis(4-carbamimidoylphenoxy)phenyl)cyclohexanecarboxamide","(1r,4r)-4-amino-N-(3,5-bis(4-carbamimidoylphenoxy)phenyl)cyclohexanecarboxamide","C000600996",0,0,2,0,0,0,0]
["(1RS,5SR,6RS)-5-hydroxybicyclo(4.3.0)non-2-ene-2-carbaldehyde","(1RS,5SR,6RS)-5-hydroxybicyclo(4.3.0)non-2-ene-2-carbaldehyde","C543382",0,0,2,0,0,0,0]
["(1S*,3R*,5R*)-3-methyl-2-oxa-bicyclo(3.3.1)nonan-7-one","(1S*,3R*,5R*)-3-methyl-2-oxa-bicyclo(3.3.1)nonan-7-one","C579827",0,0,0,0,2,0,0]
["(1S,2E,4R,6R,7E,11E)-2,7,11-cembratriene-4,6-diol","(1S,2E,4R,6R,7E,11E)-2,7,11-cembratriene-4,6-diol","C569865",0,0,2,0,0,0,0]
["(1S,2S)-2-(2-(N-((3-benzimidazol-2-yl)propyl)-N-methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride","(1S,2S)-2-(2-(N-((3-benzimidazol-2-yl)propyl)-N-methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride","C484287",0,0,6,1,2,0,0]
["(1S,2S,3E,7E,11E)-3,7,11,15-cembratetraen-17,2-olide","(1S,2S,3E,7E,11E)-3,7,11,15-cembratetraen-17,2-olide","C576714",0,0,2,0,4,0,0]
["(1-vinyl-2-pyrrolidone)-(maleic anhydride) copolymer","(1-vinyl-2-pyrrolidone)-(maleic anhydride) copolymer","C102419",2,0,0,0,0,0,0]
["(2 S)-5,7,4'-trihydroxy-2'-methoxy-8,5'- di(3-methyl-2-butenyl)-6-methyflavanone","(2 S)-5,7,4'-trihydroxy-2'-methoxy-8,5'- di(3-methyl-2-butenyl)-6-methyflavanone","C555980",0,0,2,0,0,0,0]
["(2'-((cyclopropanecarbonylethylamino)methyl)-6-methoxy-4'-trifluoromethyl-biphenyl-3-yl)acetic acid","(2'-((cyclopropanecarbonylethylamino)methyl)-6-methoxy-4'-trifluoromethyl-biphenyl-3-yl)acetic acid","C548542",0,0,0,2,0,0,0]
["(2-(1-(3-methoxycarbonylmethyl-1H-indol-2-yl)-1-methylethyl)-1H-indol-3-yl)acetic acid methyl ester","(2-(1-(3-methoxycarbonylmethyl-1H-indol-2-yl)-1-methylethyl)-1H-indol-3-yl)acetic acid methyl ester","C559930",0,0,6,0,4,0,0]
["(2-(1-diethylaminoacetoxy)pentyl)benzoic acid (2-methoxy-4-(2-(4-nitrooxybutoxycarbonyl)vinyl))phenyl ester","(2-(1-diethylaminoacetoxy)pentyl)benzoic acid (2-methoxy-4-(2-(4-nitrooxybutoxycarbonyl)vinyl))phenyl ester","C554089",0,0,0,0,2,0,0]
["(2-(2-(4-chlorobenzyloxy)phenoxy)ethyl)-(2-(2,6-dimethoxyphenoxy)ethyl)amine","(2-(2-(4-chlorobenzyloxy)phenoxy)ethyl)-(2-(2,6-dimethoxyphenoxy)ethyl)amine","C507721",0,0,1,0,1,0,0]
["(2-(2',3'-dihydrobenzo(1,4)dioxin-6'-yl)-2-hydroxy-1-pyrrolidin-1-ylmethylethyl)nonanoic acid amide","(2-(2',3'-dihydrobenzo(1,4)dioxin-6'-yl)-2-hydroxy-1-pyrrolidin-1-ylmethylethyl)nonanoic acid amide","C520404",0,0,2,0,2,0,0]
["(2-(2,5-dimethoxyphenylthio)-6-methoxybenzylideneamino)guanidine","(2-(2,5-dimethoxyphenylthio)-6-methoxybenzylideneamino)guanidine","C541073",0,0,0,0,1,0,0]
["(2-(2,6-dichloro-phenylamino)-phenyl)-acetic acid","(2-(2,6-dichloro-phenylamino)-phenyl)-acetic acid","C546555",2,0,0,0,0,0,0]
["(2-(4-methoxyphenyl)-4-quinolinyl)(2-piperidinyl)methanol","(2-(4-methoxyphenyl)-4-quinolinyl)(2-piperidinyl)methanol","C546115",0,0,2,0,3,0,0]
["(2-(6-aminopurine-9-yl)-1-hydroxy-phosphine acyl ethyl)phosphonic acid","(2-(6-aminopurine-9-yl)-1-hydroxy-phosphine acyl ethyl)phosphonic acid","C000588614",0,0,0,0,2,0,0]
["(2,2'-6',2'')-terpyridine","(2,2'-6',2'')-terpyridine","C517923",2,0,2,0,4,0,0]
["(2,2'-bipyridyl)(pentamethylcyclopentadienyl)rhodium","(2,2'-bipyridyl)(pentamethylcyclopentadienyl)rhodium","C476958",2,0,0,0,0,0,0]
["(2,3,5,6,8,9,11,12-octahydro-N-(3-(1,4,7,10-tetraazacyclododec-1-yl)propyl)-1,4,7,10,13-benzopentaoxacyclopentadecin-15-amine)copper(II)","(2,3,5,6,8,9,11,12-octahydro-N-(3-(1,4,7,10-tetraazacyclododec-1-yl)propyl)-1,4,7,10,13-benzopentaoxacyclopentadecin-15-amine)copper(II)","C524279",2,0,0,0,0,0,0]
["(2,3,5,6-tetrafluoro-4-methoxymethylphenyl)methyl-2,2-dimethyl-3-(1-propenyl)cyclopropanecarboxylate","(2,3,5,6-tetrafluoro-4-methoxymethylphenyl)methyl-2,2-dimethyl-3-(1-propenyl)cyclopropanecarboxylate","C492600",0,0,3,0,1,0,0]
["(2,3-dihydrobenzo(b)(1,4)dioxin-2-yl)(5-(3-fluorophenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)methanone","(2,3-dihydrobenzo(b)(1,4)dioxin-2-yl)(5-(3-fluorophenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)methanone","C578257",0,0,2,0,0,0,0]
["(2,3-epoxypropyl)benzene","(2,3-epoxypropyl)benzene","C497708",0,0,0,0,0,1,0]
["(2,4-dihydroxy-5-isopropylphenyl)-(5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl)methanone","(2,4-dihydroxy-5-isopropylphenyl)-(5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl)methanone","C552103",0,0,6,0,0,0,0]
["(20S*,24R*)-epoxy-9,19-cyclolanstane-3beta,12beta,16beta,25-pentaol-3-O-beta-D-xylopyranoside","(20S*,24R*)-epoxy-9,19-cyclolanstane-3beta,12beta,16beta,25-pentaol-3-O-beta-D-xylopyranoside","C000592398",0,0,2,0,0,0,0]
["(213)Bi-DTPA-F3","(213)Bi-DTPA-F3","C580872",0,0,0,0,2,0,0]
["(23R)-26-deoxycimicifugoside","(23R)-26-deoxycimicifugoside","C540475",0,0,2,0,0,0,0]
["(24S)-ergostane-3beta,5alpha,6beta-triol","(24S)-ergostane-3beta,5alpha,6beta-triol","C586171",0,0,0,0,2,0,0]
["(25R)-17alpha-hydroxyspitost-5-en-3beta-yl O-alpha-L-rhamnopyranosyl-(1-2)-O-(alpha-L-rhamnopyranosyl-(1-3))-4-O-acetyl-beta-D-glucopyranoside","(25R)-17alpha-hydroxyspitost-5-en-3beta-yl O-alpha-L-rhamnopyranosyl-(1-2)-O-(alpha-L-rhamnopyranosyl-(1-3))-4-O-acetyl-beta-D-glucopyranoside","C000594700",0,0,0,0,2,0,0]
["(25S)-ruscogenin 1-sulfate-3-O-alpha-L-rhamnopyranoside","(25S)-ruscogenin 1-sulfate-3-O-alpha-L-rhamnopyranoside","C583591",0,0,2,0,0,0,0]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C1156,B1156)","v":"(2-adamantyl)naphthol"},"(2-adamantyl)naphthol","C574741",0,0,2,0,0,0,0]
["(2-boronoethyl)-cysteine","(2-boronoethyl)-cysteine","C425062",0,0,1,0,0,0,0]
["(2E)-3-(2-naphtyl)-1-(3'-methoxy-4'-hydroxy-phenyl)-2-propen-1-one","(2E)-3-(2-naphtyl)-1-(3'-methoxy-4'-hydroxy-phenyl)-2-propen-1-one","C556214",0,0,0,0,2,0,0]
["(2E)-3-(4-hydroxy-3-methoxyphenyl) phenylpro-2-1-one","(2E)-3-(4-hydroxy-3-methoxyphenyl) phenylpro-2-1-one","C532465",0,0,0,0,2,0,0]
["(2E)-decenal","(2E)-decenal","C476489",2,0,0,0,0,0,0]
["(2E)-N,N-dibutyl-3-(4-hydroxy-3-methoxyphenyl)acrylamide","(2E)-N,N-dibutyl-3-(4-hydroxy-3-methoxyphenyl)acrylamide","C518368",0,0,0,0,2,0,0]
["(2E)-undecenal","(2E)-undecenal","C476488",2,0,0,0,0,0,0]
["(2E,2'E)-1,1'-(3-hydroxy-5-methylbiphenyl-2,6-diyl)bis(3-(3-chlorophenyl)prop-2-en-1-one)","(2E,2'E)-1,1'-(3-hydroxy-5-methylbiphenyl-2,6-diyl)bis(3-(3-chlorophenyl)prop-2-en-1-one)","C559238",0,0,0,0,1,0,0]
["(2E,2'E)-1,1'-(4'-chloro-3-hydroxy-5-methylbiphenyl-2,6-diyl)bis(3-phenylprop-2-en-1-one)","(2E,2'E)-1,1'-(4'-chloro-3-hydroxy-5-methylbiphenyl-2,6-diyl)bis(3-phenylprop-2-en-1-one)","C559237",0,0,0,0,1,0,0]
["(2E,4E,6E,10E)-3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid","(2E,4E,6E,10E)-3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid","C487689",0,0,4,0,3,0,0]
["(2-fluoro-2',5'-dimethyl-4'-(6-(3-methyl-2-butenyloxy)pyridin-3-yl) biphenyl-4-yl)-(3-methyl-2-butenyl)amine","(2-fluoro-2',5'-dimethyl-4'-(6-(3-methyl-2-butenyloxy)pyridin-3-yl) biphenyl-4-yl)-(3-methyl-2-butenyl)amine","C538781",0,0,2,0,0,0,0]
["(2-fluorobenzyl)-(2-methyl-2-phenyl-2H-chromen-6-yl-amine)","(2-fluorobenzyl)-(2-methyl-2-phenyl-2H-chromen-6-yl-amine)","C558761",0,0,0,1,0,0,0]
["(2-hydroxy-3-methoxybenzoyl-2-aminoethyl)-bis(2,3-dihydroxybenzoyl-2-aminoethyl)amine","(2-hydroxy-3-methoxybenzoyl-2-aminoethyl)-bis(2,3-dihydroxybenzoyl-2-aminoethyl)amine","C420445",2,0,0,0,0,0,0]
["(2-hydroxy-5-methoxyphenyl)(9H-pyrido(2,3-b)indol-3-yl)methanone","(2-hydroxy-5-methoxyphenyl)(9H-pyrido(2,3-b)indol-3-yl)methanone","C000605533",0,0,0,0,2,0,0]
["(2-hydroxyaminovinyl)triphenylphosphonium","(2-hydroxyaminovinyl)triphenylphosphonium","C528230",0,0,0,0,4,0,0]
["(2-hydroxybenzoyl-2-aminoethyl)-bis(2,3-dihydroxybenzoyl-2-aminoethyl)amine","(2-hydroxybenzoyl-2-aminoethyl)-bis(2,3-dihydroxybenzoyl-2-aminoethyl)amine","C420444",2,0,0,0,0,0,0]
["(2-hydroxyethyl) trimethylammonium hydroxide","(2-hydroxyethyl) trimethylammonium hydroxide","C528098",2,0,0,0,0,0,0]
["(2-methyl-4-phenyl-4H-benzo(4,5)thiazolo(3,2-a)pyrimidin-3-yl)(4-methylpiperazin-1-yl)methanone","(2-methyl-4-phenyl-4H-benzo(4,5)thiazolo(3,2-a)pyrimidin-3-yl)(4-methylpiperazin-1-yl)methanone","C000589304",0,0,2,0,0,0,0]
["(2-methyl-n-butyl)shikonin","(2-methyl-n-butyl)shikonin","C583586",0,0,2,0,2,0,0]
["(2-phenylthiazol-4-yl)-(3,4,5-trimethoxyphenyl)methanone","(2-phenylthiazol-4-yl)-(3,4,5-trimethoxyphenyl)methanone","C550330",0,0,2,0,2,0,0]
["(2R,3R)-3,5-dihydroxy-7-methoxyflavanone 3-(2-methyl)butyrate","(2R,3R)-3,5-dihydroxy-7-methoxyflavanone 3-(2-methyl)butyrate","C549662",0,0,0,0,1,0,0]
["(2R,3S)-3',4',5,7-tetrahydroxyflavan-3-yl octadecanoate","(2R,3S)-3',4',5,7-tetrahydroxyflavan-3-yl octadecanoate","C509175",0,0,2,0,0,0,0]
["(2R,3S)-pinobanksin-3-cinnamate","(2R,3S)-pinobanksin-3-cinnamate","C000591505",0,0,0,0,2,0,0]
["(2R,3Z)-N-(1-hydroxyoctadec-3-en-2-yl)pivalamide","(2R,3Z)-N-(1-hydroxyoctadec-3-en-2-yl)pivalamide","C559741",0,0,0,0,2,0,0]
["(2S)-2-(4-(((3S)-1-acetimidoyl-3-pyrrolidinyl)oxy)phenyl)-3-(7-amidino-2-naphtyl)propanoic acid","(2S)-2-(4-(((3S)-1-acetimidoyl-3-pyrrolidinyl)oxy)phenyl)-3-(7-amidino-2-naphtyl)propanoic acid","C086910",4,0,0,0,0,0,0]
["(2'S)-columbianetin-3'-sulfate","(2'S)-columbianetin-3'-sulfate","C548752",0,0,0,0,2,0,0]
["(2''S,3aR,6S,7aR)-3''-acetyl-3a,7a-dihydro-2,2,2'-2',-tetramethyl-5'-(4-bromophenyl)-spiro(spiro(1,3-dioxolo(4,5-D)-pyrane-6(7H),5'(4'H)-1',3'-dioxolo)-7(6H),2''(3''H)-(1,3,4)-oxadiazole)","(2''S,3aR,6S,7aR)-3''-acetyl-3a,7a-dihydro-2,2,2'-2',-tetramethyl-5'-(4-bromophenyl)-spiro(spiro(1,3-dioxolo(4,5-D)-pyrane-6(7H),5'(4'H)-1',3'-dioxolo)-7(6H),2''(3''H)-(1,3,4)-oxadiazole)","C512376",0,0,2,0,0,0,0]
["(2S,3S)-pterosin C 3-O-beta-D-(40-(E)-caffeoyl)-glucopyranoside","(2S,3S)-pterosin C 3-O-beta-D-(40-(E)-caffeoyl)-glucopyranoside","C000622494",0,0,2,0,0,0,0]
["(2S,3S)-pterosin C 3-O-beta-D-(6'-(E)-p-coumaroyl)-glucopyranoside","(2S,3S)-pterosin C 3-O-beta-D-(6'-(E)-p-coumaroyl)-glucopyranoside","C000622495",0,0,2,0,0,0,0]
["(2S,3S,4R,8Z)-1-O-(beta-D-galactopyranosyl)-2N-((2'R)-2'-hydroxypentacosanoilamino)8(Z)-octadecene-1,3,4-triol","(2S,3S,4R,8Z)-1-O-(beta-D-galactopyranosyl)-2N-((2'R)-2'-hydroxypentacosanoilamino)8(Z)-octadecene-1,3,4-triol","C550892",0,0,2,0,0,0,0]
["(2S,4R)-methyl-1-acetyl-4-(N-(4-bromophenyl)sulfamoyloxy)pyrrolidine-2-carboxylate","(2S,4R)-methyl-1-acetyl-4-(N-(4-bromophenyl)sulfamoyloxy)pyrrolidine-2-carboxylate","C560356",0,0,2,0,0,0,0]
["(2S,4S,10R)-4-(3-hydroxy-4-methoxyphenyl)-quinolizidin-2-acetate","(2S,4S,10R)-4-(3-hydroxy-4-methoxyphenyl)-quinolizidin-2-acetate","C531207",0,0,2,0,0,0,0]
["(2'S,7'S)-O-2-methylbutanoyl-columbianetin","(2'S,7'S)-O-2-methylbutanoyl-columbianetin","C548753",0,0,0,0,2,0,0]
["(3-((2,3,4,5-tetrahydroxyhexane-1,6-diyl)))di-1H-imidazole","(3-((2,3,4,5-tetrahydroxyhexane-1,6-diyl)))di-1H-imidazole","C523912",2,0,0,0,0,0,0]
["(3-((2,3-dihydroxybutane-1,4-diyl)))-di-1H-imidazole","(3-((2,3-dihydroxybutane-1,4-diyl)))-di-1H-imidazole","C523911",2,0,0,0,0,0,0]
["(3-(1H-indol-2-yl)phenyl)(1H-indol-2-yl)methanone","(3-(1H-indol-2-yl)phenyl)(1H-indol-2-yl)methanone","C557277",0,0,4,0,2,0,0]
["(3-(1H-indol-2-yl)phenyl)(3,4,5-trimethoxyphenyl)methanone","(3-(1H-indol-2-yl)phenyl)(3,4,5-trimethoxyphenyl)methanone","C556166",0,0,0,0,2,0,0]
["(3-(2,6-dichloro-phenylamino)phenyl)acetic acid 2-methanesulphonylsulphanyl ethyl ester","(3-(2,6-dichloro-phenylamino)phenyl)acetic acid 2-methanesulphonylsulphanyl ethyl ester","C573319",0,0,0,0,2,0,0]
["(3-(4-tolylamino)-5-amino-1H-1,2,4-triazol-1-yl)(3,4,5-trimethoxyphenyl)methanone","(3-(4-tolylamino)-5-amino-1H-1,2,4-triazol-1-yl)(3,4,5-trimethoxyphenyl)methanone","C000595013",0,0,2,0,2,0,0]
["(3-(benzyloxy)-4-methoxyphenyl)(5,6,7-trimethoxy-1-methyl-1H-indol-3-yl)methanone","(3-(benzyloxy)-4-methoxyphenyl)(5,6,7-trimethoxy-1-methyl-1H-indol-3-yl)methanone","C582560",0,0,2,0,0,0,0]
["(3,10-dihydroxybenz(c)xanthene-7-yl)-4-carboxy-2-methylbenzene","(3,10-dihydroxybenz(c)xanthene-7-yl)-4-carboxy-2-methylbenzene","C533355",2,0,0,0,0,0,0]
["(3,3')spiro((hexahydropyrrolo(1,2-a)pyrazine-1,4-dione)-6,3'-(2',3'-dihydrothieno(2,3-b)naphtho-4',9'-dione))","(3,3')spiro((hexahydropyrrolo(1,2-a)pyrazine-1,4-dione)-6,3'-(2',3'-dihydrothieno(2,3-b)naphtho-4',9'-dione))","C553169",0,0,2,0,2,0,0]
["(3,3'-diphenyl-1,1'-binaphthyl)-20-crown-6","(3,3'-diphenyl-1,1'-binaphthyl)-20-crown-6","C530035",2,0,0,0,0,0,0]
["(3,4-dihydroxyphenylamino)-2-imidazoline","(3,4-dihydroxyphenylamino)-2-imidazoline","C011775",2,0,0,0,1,0,0]
["(3,5,6-trimethylpyrazin-2-yl)methyl 2-(4-(2-methylpropyl)phenyl)propanoate","(3,5,6-trimethylpyrazin-2-yl)methyl 2-(4-(2-methylpropyl)phenyl)propanoate","C495410",0,2,0,0,0,0,0]
["(3,5-bis((4-fluorophenyl)methylidene)-1-((1-hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl)piperidin-4-one)","(3,5-bis((4-fluorophenyl)methylidene)-1-((1-hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl)piperidin-4-one)","C541427",0,0,8,0,11,0,0]
["(3,6-dimethyl-2-(2,4,6-trimethylphenoxy)pyridin-4-yl)(1-ethylpropyl)amine","(3,6-dimethyl-2-(2,4,6-trimethylphenoxy)pyridin-4-yl)(1-ethylpropyl)amine","C529296",0,0,0,0,0,1,0]
["(3alpha,5beta,17beta)-3-hydroxy-18-norandrostane-17-carbonitrile","(3alpha,5beta,17beta)-3-hydroxy-18-norandrostane-17-carbonitrile","C495276",0,0,0,0,0,1,0]
["(3-amino-4-methoxyphenyl)(2-hydroxy-3,4,5-trimethoxyphenyl)methanone","(3-amino-4-methoxyphenyl)(2-hydroxy-3,4,5-trimethoxyphenyl)methanone","C000593389",0,0,2,0,0,0,0]
["(3-aminopropyl)dimethylethoxysilane","(3-aminopropyl)dimethylethoxysilane","C582385",2,0,0,0,0,0,0]
["(3-aminopropyl)dimethylmethoxysilane","(3-aminopropyl)dimethylmethoxysilane","C543126",2,0,0,0,0,0,0]
["(3-chloro-2-hydroxypropyl)trimethylammonium chloride","(3-chloro-2-hydroxypropyl)trimethylammonium chloride","C496948",6,0,0,0,0,0,0]
["(3-chloro-4-fluoro-phenyl)-(6-(4-diethylaminomethyl-piperidin-1yl)-pyrimido(5,4-d)pyrimidin-4-yl)amine","(3-chloro-4-fluoro-phenyl)-(6-(4-diethylaminomethyl-piperidin-1yl)-pyrimido(5,4-d)pyrimidin-4-yl)amine","C495482",0,0,0,0,2,0,0]
["(3-dimyristyloxypropyl)(dimethyl)(hydroxyethyl)ammonium","(3-dimyristyloxypropyl)(dimethyl)(hydroxyethyl)ammonium","C087276",2,0,0,0,0,0,0]
["(3-ethyl-2-methyl-quinolin-6-yl)-(4-methoxycyclohexyl)methanone methanesulfonate","(3-ethyl-2-methyl-quinolin-6-yl)-(4-methoxycyclohexyl)methanone methanesulfonate","C502015",0,0,0,0,2,0,0]
["(3-hydroxy-4-methoxyphenyl)(2-hydroxy-3,4,5-trimethoxyphenyl)methanone","(3-hydroxy-4-methoxyphenyl)(2-hydroxy-3,4,5-trimethoxyphenyl)methanone","C000593388",0,0,2,0,0,0,0]
["(3-isocyanatopropyl) triethoxysilane","(3-isocyanatopropyl) triethoxysilane","C492426",2,0,0,0,0,0,0]
["(3-mercaptopropyl)trimethoxysilane","(3-mercaptopropyl)trimethoxysilane","C102833",16,0,0,0,0,0,0]
["(3-methylbutyryl)urea","(3-methylbutyryl)urea","C119881",2,0,0,0,0,0,0]
["(3-oxo-4-methylazaandrost-1-ene-17-yl)-2,2,2-trifluoroethyl ester carbamic acid","(3-oxo-4-methylazaandrost-1-ene-17-yl)-2,2,2-trifluoroethyl ester carbamic acid","C000594012",0,0,2,0,2,0,0]
["(3S,4aR,7S)-7,8-dihydroxy-3-methyl-3,4,10,5,6,7-hexahydro-1H-isochromen-1-one","(3S,4aR,7S)-7,8-dihydroxy-3-methyl-3,4,10,5,6,7-hexahydro-1H-isochromen-1-one","C579826",0,0,0,0,2,0,0]
["(3Z)-3-(1H-pyrrol-2-yl)-methyllidene)-1-(1-(piperidylmethyl)-1,3-dihydro-2H-indol-2-one mesylate","(3Z)-3-(1H-pyrrol-2-yl)-methyllidene)-1-(1-(piperidylmethyl)-1,3-dihydro-2H-indol-2-one mesylate","C504089",0,0,0,1,5,0,0]
["(4-(((4-(4-(2-chlorophenyl)-1-piperazinyl)-6-phenyl-2-pyrimidinyl)thio)methyl)-benzoic acid)","(4-(((4-(4-(2-chlorophenyl)-1-piperazinyl)-6-phenyl-2-pyrimidinyl)thio)methyl)-benzoic acid)","C000612188",0,0,0,0,2,0,0]
["(4-((1-(3-fluorophenyl)methyl)-1H-indazol-5-ylamino)-5-methylpyrrolo(2,1-f)(1,2,4)triazin-6-yl)carbamic acid 3-morpholinylmethyl ester","(4-((1-(3-fluorophenyl)methyl)-1H-indazol-5-ylamino)-5-methylpyrrolo(2,1-f)(1,2,4)triazin-6-yl)carbamic acid 3-morpholinylmethyl ester","C545531",0,0,2,0,2,0,0]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C1220,B1220)","v":"(4-((5,6-diphenylpyrazin-2-yl)(isopropyl)amino)butoxy)acetic acid"},"(4-((5,6-diphenylpyrazin-2-yl)(isopropyl)amino)butoxy)acetic acid","C531934",0,0,2,0,0,0,0]
["(4-(10, 13-dimethyl-3-methylsulfonyloxy-2,3,4,5,6,7,8,9,11,12,14,15,16, 17-tetradecahydro-1H-cyclopenta(a)phenanthren-17-yl)pentyl) methanesulfonate","(4-(10, 13-dimethyl-3-methylsulfonyloxy-2,3,4,5,6,7,8,9,11,12,14,15,16, 17-tetradecahydro-1H-cyclopenta(a)phenanthren-17-yl)pentyl) methanesulfonate","C544140",0,0,2,0,3,0,0]
["(4'-(10-methyl-9-anthryl)-2,2'-6',2''-terpyridine-6,6''-diyl)bis(methylenenitrilo) tetrakis(acetate)-Eu(3+)","(4'-(10-methyl-9-anthryl)-2,2'-6',2''-terpyridine-6,6''-diyl)bis(methylenenitrilo) tetrakis(acetate)-Eu(3+)","C522821",2,0,0,0,0,0,0]
["(4-(2-(3,5-bis(ethoxycarbonyloxy)phenyl)vinyl)phenyl) ethyl carbonate","(4-(2-(3,5-bis(ethoxycarbonyloxy)phenyl)vinyl)phenyl) ethyl carbonate","C000608951",0,0,2,0,2,0,0]
["(4-(3,5-bis-(2-(4-hydroxy-3-methoxy-phenyl)vinyl)-4,5-dihydro-pyrazol-1-yl)-phenyl)-(4-methyl-piperazin-1-yl)methanone","(4-(3,5-bis-(2-(4-hydroxy-3-methoxy-phenyl)vinyl)-4,5-dihydro-pyrazol-1-yl)-phenyl)-(4-methyl-piperazin-1-yl)methanone","C521695",0,0,2,0,0,0,0]
["(4-(3-chlorophenyl)piperazin-1-yl)(2-ethoxyphenyl)methanone","(4-(3-chlorophenyl)piperazin-1-yl)(2-ethoxyphenyl)methanone","C587628",0,0,0,0,4,0,0]
["(4-(4-(6-amino-5-(benzo(d)oxazol-2-yl)pyridin-3-yl)-1H-pyrazol-1-yl)piperidin-1-yl)ethanone","(4-(4-(6-amino-5-(benzo(d)oxazol-2-yl)pyridin-3-yl)-1H-pyrazol-1-yl)piperidin-1-yl)ethanone","C580772",0,0,2,0,4,0,0]
["(4-(4'-chloro-2'-fluoro)phenylamino)-6,7-dimethylquinazoline","(4-(4'-chloro-2'-fluoro)phenylamino)-6,7-dimethylquinazoline","C575425",0,0,2,0,0,0,0]
["(4-(4-chlorophenyl)-6-((4-nitrophenoxy) methyl) morpholin-3-one)","(4-(4-chlorophenyl)-6-((4-nitrophenoxy) methyl) morpholin-3-one)","C521396",0,0,0,0,1,0,0]
["(4-(5-amino-4-carbamoylimidazol-1-yl)-2,3-dihydroxycyclopentyl) methyl phosphate","(4-(5-amino-4-carbamoylimidazol-1-yl)-2,3-dihydroxycyclopentyl) methyl phosphate","C559837",0,0,2,0,2,0,0]
["(4-(7-(3,5-dimethyloxyphenyl)-1H-pyrazolo(3,4)pyridin-6-yl)-4-fluoro)benzene","(4-(7-(3,5-dimethyloxyphenyl)-1H-pyrazolo(3,4)pyridin-6-yl)-4-fluoro)benzene","C541943",0,0,0,0,2,0,0]
["(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride","(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride","D008455",0,0,0,0,0,1,0]
["(4,11-bis(carboxymethyl)-1,4,8,11-tetraazabicyclo(6.6.2)hexadecane)copper(II)","(4,11-bis(carboxymethyl)-1,4,8,11-tetraazabicyclo(6.6.2)hexadecane)copper(II)","C483895",0,0,0,1,0,0,0]
["(4,4'-diethylaminomethyl-2,2'-bipyridine)bis(2,2'-bipyridine)ruthenium(II)","(4,4'-diethylaminomethyl-2,2'-bipyridine)bis(2,2'-bipyridine)ruthenium(II)","C106537",2,0,0,0,0,0,0]
["(4,4-dimethyl-2,2-bipyridine)(acetylacetonate)copper(II)","(4,4-dimethyl-2,2-bipyridine)(acetylacetonate)copper(II)","C525246",0,0,4,0,6,0,0]
["(4-amidinophenyl)methanesulfonyl fluoride","(4-amidinophenyl)methanesulfonyl fluoride","C027226",2,0,0,0,0,0,0]
["(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)","(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)","C517041",0,0,0,0,1,0,0]
["(4-amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl)(2,3-difluoro-6-methoxyphenyl)methanone","(4-amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl)(2,3-difluoro-6-methoxyphenyl)methanone","C515235",0,0,2,0,1,0,0]
["(4-amino-2-(thiophen-3-yl)thiazol-5-yl)(3,4,5-trimethoxyphenyl)methanone","(4-amino-2-(thiophen-3-yl)thiazol-5-yl)(3,4,5-trimethoxyphenyl)methanone","C575284",0,0,2,0,2,0,0]
["(4-benzylpiperazin-1-yl)acetic acid (3-allyl-2-hydroxybenzylidene)hydrazine","(4-benzylpiperazin-1-yl)acetic acid (3-allyl-2-hydroxybenzylidene)hydrazine","C514579",4,0,6,0,28,0,0]
["(4-bromophenyl)(4-(3,4,5-trimethoxyphenyl)-1H-pyrrol-3-yl)methanone","(4-bromophenyl)(4-(3,4,5-trimethoxyphenyl)-1H-pyrrol-3-yl)methanone","C000614476",0,0,2,0,0,0,0]
["(4-bromophenyl)-3-(4-((6-(2-morpholin-4-ylethoxy)benzothiazol-2-ylamino)methyl)phenyl)urea","(4-bromophenyl)-3-(4-((6-(2-morpholin-4-ylethoxy)benzothiazol-2-ylamino)methyl)phenyl)urea","C000622737",0,0,2,0,0,0,0]
["(4-chlorophenyl)-9H-indeno(2,1-d)pyrimidine-2,4-diamine","(4-chlorophenyl)-9H-indeno(2,1-d)pyrimidine-2,4-diamine","C575841",0,0,2,0,0,0,0]
["(4-fluorophenyl)((5-(5-(5-fluoropyridin-2-yl)-1,2,4-oxadiazol-3-yl)-2-methylpiperidin-1-yl)methanone","(4-fluorophenyl)((5-(5-(5-fluoropyridin-2-yl)-1,2,4-oxadiazol-3-yl)-2-methylpiperidin-1-yl)methanone","C000594260",0,1,0,0,0,0,0]
["(4-hydroxy-3-nitrocoumarin)bis(phenanthroline)silver(I)","(4-hydroxy-3-nitrocoumarin)bis(phenanthroline)silver(I)","C539395",0,0,2,0,2,0,0]
["(4-iodobutyl)triphenylphosphonium","(4-iodobutyl)triphenylphosphonium","C456341",2,0,0,0,0,0,0]
["(4-methoxyphenyl)(3,4,5-trimethoxyphenyl)methanone","(4-methoxyphenyl)(3,4,5-trimethoxyphenyl)methanone","C560639",0,0,2,0,2,0,0]
["(4-oxo-3,4-dihydroquinazolin-2-yl)methyl 4-methoxybenzylcarbamodithioate","(4-oxo-3,4-dihydroquinazolin-2-yl)methyl 4-methoxybenzylcarbamodithioate","C000611423",0,0,2,0,0,0,0]
["(4R)-5,10-seco-19-norpregna-4,5-diene-3,10,20-trione","(4R)-5,10-seco-19-norpregna-4,5-diene-3,10,20-trione","C015501",2,0,0,0,0,0,0]
["(4-serotonyl)-4-serotonin","(4-serotonyl)-4-serotonin","C115055",2,0,0,0,0,0,0]
["(4SR,5SR)-4-(hydroxymethyl)-3-methylene-5-octyldihydrofuran-2(3H)-one","(4SR,5SR)-4-(hydroxymethyl)-3-methylene-5-octyldihydrofuran-2(3H)-one","C000618473",0,0,0,0,2,0,0]
["(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","C546624",0,1,27,0,27,0,0]
["(5-(2-methoxy-5-chloro-5-phenyl)furan-2-ylcarbonyl)guanidine","(5-(2-methoxy-5-chloro-5-phenyl)furan-2-ylcarbonyl)guanidine","C502305",2,0,0,0,0,0,0]
["(5(4),10(4),15(4),20(4)-tetra-tert-butyl-5(2),5(6),15(2),15(6)-tetrakis(2,2-bis(carboxylato)ethyl)-5,10,15,20-tetraphenylporphyrin)iron(III)","(5(4),10(4),15(4),20(4)-tetra-tert-butyl-5(2),5(6),15(2),15(6)-tetrakis(2,2-bis(carboxylato)ethyl)-5,10,15,20-tetraphenylporphyrin)iron(III)","C545844",2,0,0,0,0,0,0]
["(5,10,15,20-tetrakis(N-(benzyl-4'-carboxylate)-2-pyridinium)-21H,23H-porphine)iron(III)","(5,10,15,20-tetrakis(N-(benzyl-4'-carboxylate)-2-pyridinium)-21H,23H-porphine)iron(III)","C539253",0,0,0,0,2,0,0]
["(5,6-dimethyl-1,10-phenanthroline)(1,2-diaminocyclohexane)platinum(II)","(5,6-dimethyl-1,10-phenanthroline)(1,2-diaminocyclohexane)platinum(II)","C529817",0,0,2,0,0,0,0]
["(5,6-dimethyl-1,10-phenanthroline)(ethylenediamine)platinum(II)","(5,6-dimethyl-1,10-phenanthroline)(ethylenediamine)platinum(II)","C529819",0,0,2,0,0,0,0]
["(5-amino-3-methyl-6-methoxybenzo(b)furan-2-yl)(3,4,5-trimethoxyphenyl) methanone","(5-amino-3-methyl-6-methoxybenzo(b)furan-2-yl)(3,4,5-trimethoxyphenyl) methanone","C569481",0,0,0,0,2,0,0]
["(5aR)-5a-C-pentyl-4-epi-isofagomine","(5aR)-5a-C-pentyl-4-epi-isofagomine","C000614378",2,0,0,0,0,0,0]
["(5-chloro-N-(1,1-dioxo-1H-1lamda(6)-benzo(b)thiophen-6-yl)-2-hydroxybenzamide","(5-chloro-N-(1,1-dioxo-1H-1lamda(6)-benzo(b)thiophen-6-yl)-2-hydroxybenzamide","C000595831",0,0,2,0,0,0,0]
["(5-fluoro-2-methyl-1-(3,5-dimethoxy-4-hydroxybenzylidene)-3-(N-benzyl)indene)acetamide","(5-fluoro-2-methyl-1-(3,5-dimethoxy-4-hydroxybenzylidene)-3-(N-benzyl)indene)acetamide","C508487",0,0,2,0,2,0,0]
["(5-fluoro-2-methyl-1-(4-pyridyl)methylene-3-(N-benzyl)-indene)-acetamide hydrochloride","(5-fluoro-2-methyl-1-(4-pyridyl)methylene-3-(N-benzyl)-indene)-acetamide hydrochloride","C439285",0,0,2,0,14,0,0]
["(5-fluoro-2-methyl-3-quinolin-2-ylmethylindo-1-yl)acetic acid","(5-fluoro-2-methyl-3-quinolin-2-ylmethylindo-1-yl)acetic acid","C571151",0,0,0,0,2,0,0]
["(5-methyl-1,10-phenanthroline)(1,2-diaminocyclohexane)platinum(II)","(5-methyl-1,10-phenanthroline)(1,2-diaminocyclohexane)platinum(II)","C529818",0,0,2,0,0,0,0]
["(5-tert-butyl-2-hydroxyisophthalaldehyde-bis-2-pyridinehydrazone)Zn(II)","(5-tert-butyl-2-hydroxyisophthalaldehyde-bis-2-pyridinehydrazone)Zn(II)","C584230",2,0,0,0,0,0,0]
["(5Z)-7-((1R,2R, 3R,5S)-2-((1E)-3,3-difluoro-4-phenoxy -1-butenyl)-3,5-dihydroxycyclopentyl)-5-heptenoic acid","(5Z)-7-((1R,2R, 3R,5S)-2-((1E)-3,3-difluoro-4-phenoxy -1-butenyl)-3,5-dihydroxycyclopentyl)-5-heptenoic acid","C485334",0,0,2,0,0,0,0]
["(6-(3-chloro-4-fluoro-benzyl)-4-hydroxy-2-methyl-3,5-dioxo-2,3,5,6,7,8-hexahydro-(2,6)naphthyridine-1-carboxylic acid dimethylamide)","(6-(3-chloro-4-fluoro-benzyl)-4-hydroxy-2-methyl-3,5-dioxo-2,3,5,6,7,8-hexahydro-(2,6)naphthyridine-1-carboxylic acid dimethylamide)","C538972",2,0,0,0,0,0,0]
["(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine","(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine","C516138",0,0,21,0,21,0,0]
["(6-(thiophen-2-yl)-3-(3,4,5-trimethoxyphenyl)-6,7-dihydro-5H-(1,2,4)triazolo(3,4-b)(1,3,4)thiadiazin-7-yl)(p-tolyl)methanone","(6-(thiophen-2-yl)-3-(3,4,5-trimethoxyphenyl)-6,7-dihydro-5H-(1,2,4)triazolo(3,4-b)(1,3,4)thiadiazin-7-yl)(p-tolyl)methanone","C000607136",0,0,2,0,0,0,0]
["(6,7-dimethoxy-2,4-dihydroindeno(1,2-c)pyrazol-3-yl)(3-fluorophenyl)amine","(6,7-dimethoxy-2,4-dihydroindeno(1,2-c)pyrazol-3-yl)(3-fluorophenyl)amine","C505208",2,0,0,0,0,0,0]
["(6,7-dimethoxyquinolin-4-yl)(5-methoxy-2,2-dimethyl-2H-chromen-6-yl)methyl acetate","(6,7-dimethoxyquinolin-4-yl)(5-methoxy-2,2-dimethyl-2H-chromen-6-yl)methyl acetate","C000601052",0,0,2,0,0,0,0]
["(68Ga)Glu-urea-Lys(Ahx)-HBED-CC","(68Ga)Glu-urea-Lys(Ahx)-HBED-CC","C000604952",2,0,0,0,0,0,0]
["(6-amino-1-methyl-5-nitrosouracilato-N3)triphenylphosphinegold(I)","(6-amino-1-methyl-5-nitrosouracilato-N3)triphenylphosphinegold(I)","C584133",0,0,2,0,0,0,0]
["(6E,10E)isopolycerasoidol","(6E,10E)isopolycerasoidol","C000606813",0,0,0,0,2,0,0]
["(6E,10E)isopolycerasoidol methyl ester","(6E,10E)isopolycerasoidol methyl ester","C000606814",0,0,0,0,2,0,0]
["(7.7)paracyclophane","(7.7)paracyclophane","C544518",0,0,1,0,0,0,0]
["(7-diethylaminocoumarin-4-yl)methyl phosphate","(7-diethylaminocoumarin-4-yl)methyl phosphate","C556999",2,0,0,0,0,0,0]
["(7-hydroxy-4-methylcoumarin)cerium(III)","(7-hydroxy-4-methylcoumarin)cerium(III)","C493506",2,0,0,0,0,0,0]
["(7''R)-8-(1-(4'-hydroxy-3'-methoxyphenyl)prop-2-en-1-yl)chrysin","(7''R)-8-(1-(4'-hydroxy-3'-methoxyphenyl)prop-2-en-1-yl)chrysin","C549661",0,0,0,0,1,0,0]
["(7''R)-8-(1-(4'-hydroxy-3'-methoxyphenyl)prop-2-en-1-yl)galangin","(7''R)-8-(1-(4'-hydroxy-3'-methoxyphenyl)prop-2-en-1-yl)galangin","C549660",0,0,0,0,1,0,0]
["(8R)-3beta,8-dihydroxypolypoda-13E,17E,21-triene","(8R)-3beta,8-dihydroxypolypoda-13E,17E,21-triene","C562122",0,0,0,0,2,0,0]
["(8R,9S)-8,9-dihydro-6,9-epoxy-8,9-anhydropseudoerythromycin A","(8R,9S)-8,9-dihydro-6,9-epoxy-8,9-anhydropseudoerythromycin A","C560918",0,2,0,0,0,0,0]
["(90)Y-2,3-dicarboxypropane-1,1-diphosphonic acid","(90)Y-2,3-dicarboxypropane-1,1-diphosphonic acid","C528986",2,0,0,0,0,0,0]
["(all-E) phytoene","(all-E) phytoene","C100185",0,0,0,0,1,0,0]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C1284,B1284)","v":"(Au(d2pypp)(2))Cl"},"(Au(d2pypp)(2))Cl","C523596",0,0,2,0,2,0,0]
["(benzoxazol-2-ylmethyl)phosphonic acid","(benzoxazol-2-ylmethyl)phosphonic acid","C555445",2,0,0,0,0,0,0]
["(bipyridine)(2-phenyl(5-fluoro)-imidazo(f)-1,10-phenathroline)ruthenium","(bipyridine)(2-phenyl(5-fluoro)-imidazo(f)-1,10-phenathroline)ruthenium","C465028",2,0,0,0,0,0,0]
["(bipyridine)(morpholine dithiocarbamate)platinum(II)","(bipyridine)(morpholine dithiocarbamate)platinum(II)","C000589196",2,0,0,0,2,0,0]
["(bis(3,5-dimethylpyrazol-1-yl)acetate)bis(tris(hydroxymethyl)phosphine)copper(I)","(bis(3,5-dimethylpyrazol-1-yl)acetate)bis(tris(hydroxymethyl)phosphine)copper(I)","C517226",0,0,0,0,2,0,0]
["(bromodifluoromethyl)trimethylsilane","(bromodifluoromethyl)trimethylsilane","C000599115",2,0,0,0,0,0,0]
["(bromoiso-valeryl)urea","(bromoiso-valeryl)urea","C119882",2,0,0,0,0,0,0]
["(C(2)H(10)N(2))(5)(NH(4))(4)H(2)(Se(2)W(10)V(8)O(62)).9H(2)O","(C(2)H(10)N(2))(5)(NH(4))(4)H(2)(Se(2)W(10)V(8)O(62)).9H(2)O","C541881",0,0,2,0,2,0,0]
["(Cd(C(6)H(6)O(7))(H(2)O))(n)","(Cd(C(6)H(6)O(7))(H(2)O))(n)","C478298",2,0,0,0,0,0,0]
["(Co(2-hydroxyhippuric acid)(imidazol)(3)).H(2)O (2)","(Co(2-hydroxyhippuric acid)(imidazol)(3)).H(2)O (2)","C490238",2,0,0,0,0,0,0]
["(copper2II(3,5-ditertiarybutylsalicylate)4(ethanol)4)","(copper2II(3,5-ditertiarybutylsalicylate)4(ethanol)4)","C515535",0,0,0,0,2,0,0]
["(Cr(salprn)(H2O)2)ClO4","(Cr(salprn)(H2O)2)ClO4","C417305",0,0,0,0,2,0,0]
["(Cu(4,4'-dimethyl-2,2'-bipyridine)(glycinato)(H2O))NO3","(Cu(4,4'-dimethyl-2,2'-bipyridine)(glycinato)(H2O))NO3","C586190",0,0,0,0,2,0,0]
["(Cu(4,7-dimethyl-1,10-phenanthroline)(acetylacetonato)(H2O))NO3","(Cu(4,7-dimethyl-1,10-phenanthroline)(acetylacetonato)(H2O))NO3","C586191",0,0,0,0,2,0,0]
["(Cu(4-methylcoumarin-6,7-dioxactetate)(phenanthroline)2)","(Cu(4-methylcoumarin-6,7-dioxactetate)(phenanthroline)2)","C523706",0,0,4,0,4,0,0]
["(Cu(Imidazol)(4)Cl(2))(Cu(imidazole)(4)Cl)(2)(2-hydroxyhippuric acid)(2)","(Cu(Imidazol)(4)Cl(2))(Cu(imidazole)(4)Cl)(2)(2-hydroxyhippuric acid)(2)","C490236",2,0,0,0,0,0,0]
["(Cu(Py-3')TPP-Ru(phen)2Cl)(PF6)","(Cu(Py-3')TPP-Ru(phen)2Cl)(PF6)","C547324",0,0,0,0,1,0,0]
["(diaminocyclohexane)(demethylcantharidin)platinum(II)","(diaminocyclohexane)(demethylcantharidin)platinum(II)","C534069",0,1,0,0,2,0,0]
["(diaminocyclohexane)(diacetato)(dichloro)platinum","(diaminocyclohexane)(diacetato)(dichloro)platinum","C119451",0,0,0,0,2,0,0]
["(diaminocyclohexane)bis(2-tert-butoxyacetate)platinum(II)","(diaminocyclohexane)bis(2-tert-butoxyacetate)platinum(II)","C562059",0,0,0,0,1,0,0]
["(dichloro)tetraammineruthenium(III)","(dichloro)tetraammineruthenium(III)","C543901",0,0,3,0,6,0,0]
["(diethoxyphosphoryl)-5-methylpyrroline N-oxide","(diethoxyphosphoryl)-5-methylpyrroline N-oxide","C510912",2,0,0,0,0,0,0]
["(diethylenetriamine)(imidazoline)copper(II) perchlorate","(diethylenetriamine)(imidazoline)copper(II) perchlorate","C500448",2,0,0,0,0,0,0]
["(diethylenetriamine)-platinum(II)","(diethylenetriamine)-platinum(II)","C438825",2,0,0,0,0,0,0]
["(dimethoxyphosphoryl)methyl 2-methylacrylate","(dimethoxyphosphoryl)methyl 2-methylacrylate","C582225",2,0,0,0,0,0,0]
["(E)-((3-cyclopentyloxy-4-methoxyphenyl)methylene)-hydrazinecarboxamide","(E)-((3-cyclopentyloxy-4-methoxyphenyl)methylene)-hydrazinecarboxamide","C483181",0,2,0,0,0,0,0]
["(E)-1-(2,3,6-trimethylphenyl)buta-1,3-diene","(E)-1-(2,3,6-trimethylphenyl)buta-1,3-diene","C504097",2,0,0,0,0,0,0]
["(E)-1-(2'-hydroxy-4',6'-dimethoxyphenyl)-3-(4-methylthio)phenyl)prop-2-ene-1-one","(E)-1-(2'-hydroxy-4',6'-dimethoxyphenyl)-3-(4-methylthio)phenyl)prop-2-ene-1-one","C000617911",0,0,2,0,2,0,0]
["(E)-1-(2-hydroxyphenyl)-3-(2-methoxynaphthalen-1-yl)prop-2-en-1-one","(E)-1-(2-hydroxyphenyl)-3-(2-methoxynaphthalen-1-yl)prop-2-en-1-one","C000619667",0,0,0,0,2,0,0]
["(E)-1-(2-nitrovinyl)naphthalene","(E)-1-(2-nitrovinyl)naphthalene","C000599592",0,0,0,0,1,0,0]
["(E)-1-(3,4-dihydroxyphenethyl)-3-styrylurea","(E)-1-(3,4-dihydroxyphenethyl)-3-styrylurea","C548394",0,0,6,0,4,0,0]
["(E)-1-(3'-fluoro-(1,1'-biphenyl-3-yl)-3-(3-hydroxy-4-methoxyphenyl)prop-2-en-1-one)","(E)-1-(3'-fluoro-(1,1'-biphenyl-3-yl)-3-(3-hydroxy-4-methoxyphenyl)prop-2-en-1-one)","C000617793",0,0,0,0,2,0,0]
["(E)-1-(4-tert-butylbenzyl)-N'-(1-(5-chloro-2-hydroxyphenyl) ethylidene)-3-(4-chlorophenyl)-1H-pyrazole-5-carbohydrazide","(E)-1-(4-tert-butylbenzyl)-N'-(1-(5-chloro-2-hydroxyphenyl) ethylidene)-3-(4-chlorophenyl)-1H-pyrazole-5-carbohydrazide","C540832",0,0,0,0,1,0,0]
["(E)-3-(1H-Indol-3-yl)-N-(2,4,6-trimethoxyphenyl)acrylamide","(E)-3-(1H-Indol-3-yl)-N-(2,4,6-trimethoxyphenyl)acrylamide","C000600993",0,0,2,0,2,0,0]
["(E)-3-(2-bromophenyl)-N-(4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)phenyl)acrylamide","(E)-3-(2-bromophenyl)-N-(4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)phenyl)acrylamide","C546525",0,0,2,0,0,0,0]
["(E)-3-(5-(5-chloro-2,4-dihydroxyphenyl)-4-(4-hydroxyphenyl)isoxazol-3-yl)-1-(4-(2-methoxyphenyl)piperazin-1-yl)prop-2-en-1-one","(E)-3-(5-(5-chloro-2,4-dihydroxyphenyl)-4-(4-hydroxyphenyl)isoxazol-3-yl)-1-(4-(2-methoxyphenyl)piperazin-1-yl)prop-2-en-1-one","C000595383",0,0,2,0,0,0,0]
["(E)-3-(hydroxy(4-nitrophenyl)methyl)-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one","(E)-3-(hydroxy(4-nitrophenyl)methyl)-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one","C583250",0,0,0,0,2,0,0]
["(E)-3-(hydroxy(phenyl)methyl)-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one","(E)-3-(hydroxy(phenyl)methyl)-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one","C583249",0,0,0,0,2,0,0]
["(E)-3-(hydroxy(thiophen-2-yl)methyl)-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one","(E)-3-(hydroxy(thiophen-2-yl)methyl)-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one","C583248",0,0,0,0,2,0,0]
["(E)-4-(ethoxymethylene)-2-phenyloxazol-5(4H)-one","(E)-4-(ethoxymethylene)-2-phenyloxazol-5(4H)-one","C570750",2,0,0,0,0,0,0]
["(E)-4-carboxystyryl-4-chlorobenzylsulfone, sodium salt","(E)-4-carboxystyryl-4-chlorobenzylsulfone, sodium salt","C520364",0,0,2,0,4,0,0]
["(E)-4-hydroxy-3-methylbut-2-enyl diphosphate","(E)-4-hydroxy-3-methylbut-2-enyl diphosphate","C547602",0,0,4,0,0,0,0]
["(E)-8-acetoxy-2-(2-(3,4-diacetoxyphenyl)ethenyl)quinazoline","(E)-8-acetoxy-2-(2-(3,4-diacetoxyphenyl)ethenyl)quinazoline","C000615691",0,0,0,0,2,0,0]
["(E)-9-(2-nitrovinyl)anthracene","(E)-9-(2-nitrovinyl)anthracene","C000599593",2,0,0,0,1,0,0]
["(E)-alpha-benzylthio chalcone","(E)-alpha-benzylthio chalcone","C549755",0,0,2,0,0,0,0]
["(E)-methyl 2-(7-chloroquinolin-4-ylthio)-3-(4-hydroxyphenyl)acrylate","(E)-methyl 2-(7-chloroquinolin-4-ylthio)-3-(4-hydroxyphenyl)acrylate","C000589136",0,0,2,0,0,0,0]
["(E)-oxindolylidene acetate","(E)-oxindolylidene acetate","C000610865",0,0,2,0,0,0,0]
["(eta(5)-cyclopentadienyl)(1,2-bis(diphenylphosphine)ethane)(1,3,5-triazine)ruthenium(II)","(eta(5)-cyclopentadienyl)(1,2-bis(diphenylphosphine)ethane)(1,3,5-triazine)ruthenium(II)","C539770",0,0,2,0,0,0,0]
["(eta(5)-cyclopentadienyl)(pyridazine)bis(triphenyphosphine)ruthenium(II)","(eta(5)-cyclopentadienyl)(pyridazine)bis(triphenyphosphine)ruthenium(II)","C539771",0,0,2,0,0,0,0]
["(eta6-p-cymene)Ru(9-aminoacridine)Cl","(eta6-p-cymene)Ru(9-aminoacridine)Cl","C543743",0,0,2,0,0,0,0]
["(ethanol)(2,3,7,8,12,13,17,18-octaethylporphinato)manganese(III) perchlorate","(ethanol)(2,3,7,8,12,13,17,18-octaethylporphinato)manganese(III) perchlorate","C103292",2,0,0,0,0,0,0]
["(ethylenedinitrilo)-tetramethylenephosphonic acid","(ethylenedinitrilo)-tetramethylenephosphonic acid","C018940",4,0,0,0,0,0,0]
["(Fe(III)Mn(II)(BPBPMP)(OAc)(2))ClO(4)","(Fe(III)Mn(II)(BPBPMP)(OAc)(2))ClO(4)","C472285",2,0,0,0,0,0,0]
["(fluorescein-6-carbonyloxy)acetoaminomethylene bisphosphonic acid","(fluorescein-6-carbonyloxy)acetoaminomethylene bisphosphonic acid","C104510",2,0,0,0,0,0,0]
["(glycinato-kappa(2)N,O)oxidobis(peroxido-kappa(2)O,O')vanadate(V) tetrahydrate","(glycinato-kappa(2)N,O)oxidobis(peroxido-kappa(2)O,O')vanadate(V) tetrahydrate","C587648",2,0,0,0,0,0,0]
["(isonicotinic acid (2-(4,4,5,5-tetramethyl-(1,3,2)dioxaborolan-2-yl)benzylidene)hydrazide)","(isonicotinic acid (2-(4,4,5,5-tetramethyl-(1,3,2)dioxaborolan-2-yl)benzylidene)hydrazide)","C541518",0,0,0,0,2,0,0]
["(lactide-co-glycolide)-monomethoxy-poly(polyethylene glycol)","(lactide-co-glycolide)-monomethoxy-poly(polyethylene glycol)","C000614851",2,0,0,0,0,0,0]
["(M)-bicelaphanol A","(M)-bicelaphanol A","C582699",0,0,0,0,2,0,0]
["(meso-tetrakis(sulfonatomesityl)porphyrinato)iron(III)","(meso-tetrakis(sulfonatomesityl)porphyrinato)iron(III)","C521848",2,0,0,0,0,0,0]
["(methyl 2,3,6-trideoxy-alpha-talopyranosido)-(3,2-d)-2-cyclohexanone","(methyl 2,3,6-trideoxy-alpha-talopyranosido)-(3,2-d)-2-cyclohexanone","C045834",2,0,0,0,0,0,0]
["(MnIV4O5(terpy)4(H2O)2)(ClO4)6","(MnIV4O5(terpy)4(H2O)2)(ClO4)6","C490328",2,0,0,0,0,0,0]
["(mu4-oxo)tetra-mu4-acetate(4-hydroxy-3,5-bis(morpholinomethyl))tetracopper(II)","(mu4-oxo)tetra-mu4-acetate(4-hydroxy-3,5-bis(morpholinomethyl))tetracopper(II)","C585577",0,0,0,0,2,0,0]
["(N(1),N(12))bis(ethyl)-6,7-dehydrospermine","(N(1),N(12))bis(ethyl)-6,7-dehydrospermine","C415967",0,0,4,0,4,0,0]
["(N'-(2-hydroxybenzylidene)-1-benzyl-3-phenyl-1H-pyrazole-5-carbohydrazide)copper(II)","(N'-(2-hydroxybenzylidene)-1-benzyl-3-phenyl-1H-pyrazole-5-carbohydrazide)copper(II)","C545878",0,0,0,0,1,0,0]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C1348,B1348)","v":"(N-(3,5-dichloro-2-oxidobenzylidene)-4-chlorobenzyhydrazidato)(o-methylbenzyl)aquatin(IV)"},"(N-(3,5-dichloro-2-oxidobenzylidene)-4-chlorobenzyhydrazidato)(o-methylbenzyl)aquatin(IV)","C000610766",0,0,2,0,2,0,0]
["(N-(4-(2,2,2-trifluoroethyl) benzylidene) (7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthren-1-yl) meth-anamine)","(N-(4-(2,2,2-trifluoroethyl) benzylidene) (7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthren-1-yl) meth-anamine)","C527614",0,0,2,0,1,0,0]
["(N(6)-adenyl)styrene oxide","(N(6)-adenyl)styrene oxide","C440254",2,0,0,0,0,0,0]
["(N-(N',N'-dimethylaminoethyl)-1,8-naphthalimide-4-sulfide)(triethylphosphine)gold(I)","(N-(N',N'-dimethylaminoethyl)-1,8-naphthalimide-4-sulfide)(triethylphosphine)gold(I)","C538800",0,0,0,0,2,0,0]
["(N,N'-bis(quinolin-2-yl-methylidene)octa-4-ene-2,6-diyne-1,8-diamine)zinc(II) chloride","(N,N'-bis(quinolin-2-yl-methylidene)octa-4-ene-2,6-diyne-1,8-diamine)zinc(II) chloride","C567984",0,0,0,0,2,0,0]
["(N,N-diethylamino)-4-hydroxyflavylium","(N,N-diethylamino)-4-hydroxyflavylium","C528790",2,0,0,0,0,0,0]
["(N',N''E,N',N''E)-N',N''-(((propane-1,3-diylbis(oxy))bis(2,1-phenylene))bis(methanylylidene))di(isonicotinohydrazide)","(N',N''E,N',N''E)-N',N''-(((propane-1,3-diylbis(oxy))bis(2,1-phenylene))bis(methanylylidene))di(isonicotinohydrazide)","C000603139",2,0,0,0,0,0,0]
["(NH4)4H4(Se2Mo2V4O24).7H2O","(NH4)4H4(Se2Mo2V4O24).7H2O","C569095",2,0,0,0,2,0,0]
["(Ni(Py-3')TPP-Ru(phen)2Cl)(PF6)","(Ni(Py-3')TPP-Ru(phen)2Cl)(PF6)","C547323",0,0,0,0,1,0,0]
["(nitrilotris(methylene))triphosphonic acid","(nitrilotris(methylene))triphosphonic acid","C041182",4,0,0,0,0,0,0]
["(N-methoxy-N-methyl)-4-(5-benzoylbenzimidazole-2-yl)-3,5-dimethylpyrrole-2-carboxamide hydrochloride","(N-methoxy-N-methyl)-4-(5-benzoylbenzimidazole-2-yl)-3,5-dimethylpyrrole-2-carboxamide hydrochloride","C568815",0,2,0,0,0,0,0]
["(N-propargyl-(3R) aminoindan-5-yl)-ethyl methyl carbamate","(N-propargyl-(3R) aminoindan-5-yl)-ethyl methyl carbamate","C423264",0,0,0,0,7,0,0]
["(N-salicylidene-L-glutamato)copper(II) monohydrate","(N-salicylidene-L-glutamato)copper(II) monohydrate","C530823",0,0,4,0,0,0,0]
["(polyethylene-acrylic acid) copolymer","(polyethylene-acrylic acid) copolymer","C083316",0,0,2,0,0,0,0]
["(polyethyleneiminomethyl phosphonate)tin(II)","(polyethyleneiminomethyl phosphonate)tin(II)","C489335",2,0,0,0,0,0,0]
["(Pt(2-methylthiomethylpyridine)(OH2)2)2","(Pt(2-methylthiomethylpyridine)(OH2)2)2","C572366",2,0,0,0,0,0,0]
["(Pt(NH(3))(achsh)Cl(2))","(Pt(NH(3))(achsh)Cl(2))","C460960",0,0,0,0,2,0,0]
["(R)-1-(1H-indol-3-yl)-2-phenylmethanesulfonyl-1,2,3,4-tetrahydroisoquinoline","(R)-1-(1H-indol-3-yl)-2-phenylmethanesulfonyl-1,2,3,4-tetrahydroisoquinoline","C551678",0,0,4,0,2,0,0]
["(R)-1-O-(4-(1-pyrenylethynyl)phenylmethyl)glycerol","(R)-1-O-(4-(1-pyrenylethynyl)phenylmethyl)glycerol","C507245",0,0,2,0,0,0,0]
["(R)-2-(3-((benzoxazol-2-yl-d4 (3-(4-methoxyphenoxy-d7)propyl)amino)methyl)phenoxy) butanoic acid","(R)-2-(3-((benzoxazol-2-yl-d4 (3-(4-methoxyphenoxy-d7)propyl)amino)methyl)phenoxy) butanoic acid","C540740",0,0,1,0,0,0,0]
["(R)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide","(R)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide","C000619999",0,0,2,0,0,0,0]
["(R,E)-N-(1-hydroxy-4-(tridecylthio)but-3-en-2-yl)octanamide","(R,E)-N-(1-hydroxy-4-(tridecylthio)but-3-en-2-yl)octanamide","C574152",0,0,0,0,2,0,0]
["(R,E)-N-(1-hydroxy-4-(tridecylthio)but-3-en-2-yl)pivalamide","(R,E)-N-(1-hydroxy-4-(tridecylthio)but-3-en-2-yl)pivalamide","C574131",0,0,0,0,2,0,0]
["(R,E)-N-(7-chloro-1-(1-(4-(dimethylamino)but-2-enoyl)azepan-3-yl)-1H-benzo(d)imidazol-2-yl)-2-methylisonicotinamide","(R,E)-N-(7-chloro-1-(1-(4-(dimethylamino)but-2-enoyl)azepan-3-yl)-1H-benzo(d)imidazol-2-yl)-2-methylisonicotinamide","C000619734",0,0,2,0,0,0,0]
["(R,S)-2-((8-chlorobenzofurano(2,3-b)quinolinyl)oxy)propionic acid","(R,S)-2-((8-chlorobenzofurano(2,3-b)quinolinyl)oxy)propionic acid","C511151",0,0,2,0,0,0,0]
["(R,S)-4-((4'-hydroxy-3-((4-hydroxyphenyl)ethynyl)biphenyl-2-yl)(4-hydroxyphenyl)methylene)-2,5-cyclohexadien-1-one","(R,S)-4-((4'-hydroxy-3-((4-hydroxyphenyl)ethynyl)biphenyl-2-yl)(4-hydroxyphenyl)methylene)-2,5-cyclohexadien-1-one","C530550",0,0,0,0,2,0,0]
["(Rh(bpy)2(chrysi))3+","(Rh(bpy)2(chrysi))3+","C409422",0,2,2,0,0,0,0]
["(Ru(bpy)2(Hbopip))(ClO4)2","(Ru(bpy)2(Hbopip))(ClO4)2","C513694",2,0,0,0,0,0,0]
["(ruthenium(1,4,5,8-tetraazaphenanthrene)(2)5-(4-(N-methyl-N-(7-chloroquinolin-4-yl)amino)-2-thiabutylcarboxamido)1,10-phenanthroline)","(ruthenium(1,4,5,8-tetraazaphenanthrene)(2)5-(4-(N-methyl-N-(7-chloroquinolin-4-yl)amino)-2-thiabutylcarboxamido)1,10-phenanthroline)","C453179",2,0,0,0,0,0,0]
["(S)-1-((S)-2-amino-3-(4-(1-(4-fluorobenzyl)-1H-1,2,3-triazol-4-yl)phenyl)propanoyl)pyrrolidine-2-carbonitrile hydrochloride","(S)-1-((S)-2-amino-3-(4-(1-(4-fluorobenzyl)-1H-1,2,3-triazol-4-yl)phenyl)propanoyl)pyrrolidine-2-carbonitrile hydrochloride","C587123",0,0,2,0,0,0,0]
["(S)-1-(1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one","(S)-1-(1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one","C000619637",0,0,2,0,0,0,0]
["(S)-1-(3-((2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)phenyl)amino)-1-(tetrahydrofuran-3-yl)-6,7-dihydro-1H-pyrazolo(4,3-c)pyridin-5(4H)-yl)ethanone","(S)-1-(3-((2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)phenyl)amino)-1-(tetrahydrofuran-3-yl)-6,7-dihydro-1H-pyrazolo(4,3-c)pyridin-5(4H)-yl)ethanone","C000620287",0,0,2,0,0,0,0]
["(S)-1-(5-hydroxy-1,5-dimethylhexyl)-3-(7-(4-methoxyphenyl)-(1,2,4-triazolo(1,5-a)pyrimidin-2-yl))urea","(S)-1-(5-hydroxy-1,5-dimethylhexyl)-3-(7-(4-methoxyphenyl)-(1,2,4-triazolo(1,5-a)pyrimidin-2-yl))urea","C509974",0,0,2,0,0,0,0]
["(S)-2-(3,4-dimethoxyphenyl)-1-(5-methoxy-2,2-dimethyl-2H-chromen-6-yl)propan-1-one","(S)-2-(3,4-dimethoxyphenyl)-1-(5-methoxy-2,2-dimethyl-2H-chromen-6-yl)propan-1-one","C578797",0,0,2,0,0,0,0]
["(S)-2-(benzylideneamino)-3-hydroxy-N-tetrade-cylpropanamide","(S)-2-(benzylideneamino)-3-hydroxy-N-tetrade-cylpropanamide","C573361",0,0,2,0,2,0,0]
["(S)-2,3-dihydrobenzo(b)furan-3-carboxylic acid","(S)-2,3-dihydrobenzo(b)furan-3-carboxylic acid","C576845",2,0,0,0,0,0,0]
["(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one","(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one","C470586",0,0,0,0,2,0,0]
["(S)-4-amino-4,5-dihydro-2-thiophenecarboxylic acid","(S)-4-amino-4,5-dihydro-2-thiophenecarboxylic acid","C524002",2,0,0,0,0,0,0]
["(S)-4-tert-butyldimethylsilyloxy-2-cyclopenten-1-one","(S)-4-tert-butyldimethylsilyloxy-2-cyclopenten-1-one","C486212",0,0,0,0,2,0,0]
["(S)-5-chloro-2,3-dihydrobenzo(b)furan-3-carboxylic acid","(S)-5-chloro-2,3-dihydrobenzo(b)furan-3-carboxylic acid","C576846",2,0,0,0,0,0,0]
["(S)-chloro-1-(2-thienyl)-1-propanol","(S)-chloro-1-(2-thienyl)-1-propanol","C581188",2,0,1,0,0,0,0]
["(S)-trans-gamma-monocyclofarnesol","(S)-trans-gamma-monocyclofarnesol","C578736",2,0,0,0,0,0,0]
["(S,S)-ethylenediaminedisuccinate","(S,S)-ethylenediaminedisuccinate","C499100",8,0,0,0,0,0,0]
["(Z)-2-(6-(thieanisyl-2-yl)hexa-3-en-1,5-diynyl)benzenamine","(Z)-2-(6-(thieanisyl-2-yl)hexa-3-en-1,5-diynyl)benzenamine","C518618",0,0,2,0,2,0,0]
["(Z)-2-amino-5-chlorobenzophenonamidinohydrazone acetate","(Z)-2-amino-5-chlorobenzophenonamidinohydrazone acetate","C080444",2,0,0,0,0,0,0]
["(Z)-3,4,3',5'-tetramethoxystilbene","(Z)-3,4,3',5'-tetramethoxystilbene","C582758",0,0,2,0,2,0,0]
["(Z)-7-acetoxy-methyl-11-methyl-3-methylene-dodeca-1,6,10-triene","(Z)-7-acetoxy-methyl-11-methyl-3-methylene-dodeca-1,6,10-triene","C556213",0,0,2,0,2,0,0]
["027075 compound","027075 compound","C000620092",0,0,0,0,2,0,0]
["1 alpha-(hydroxymethyl)-25-hydroxyvitamin D3","1 alpha-(hydroxymethyl)-25-hydroxyvitamin D3","C076210",0,0,1,0,0,0,0]
["1 alpha,24-dihydroxyvitamin D3","1 alpha,24-dihydroxyvitamin D3","C023850",0,1,14,2,9,0,0]
["1 alpha-hydroxyergocalciferol","1 alpha-hydroxyergocalciferol","C042533",0,0,2,0,2,0,0]
["1-(((3-hydroxy-1-adamantyl)amino)acetyl)-2-cyanopyrrolidine","1-(((3-hydroxy-1-adamantyl)amino)acetyl)-2-cyanopyrrolidine","C475520",0,0,0,0,2,0,0]
["1-((1-methyl-5-(2-(4-(2-(1-methylethoxy)phenyl)-1-piperazinyl)ethyl)-1H-pyrrol-2-yl)methyl)-2-piperidone","1-((1-methyl-5-(2-(4-(2-(1-methylethoxy)phenyl)-1-piperazinyl)ethyl)-1H-pyrrol-2-yl)methyl)-2-piperidone","C096245",2,0,0,0,0,0,0]
["1-((1-O-octadecyl-2-O-methylglycero)phospho)-3-deoxy-myo-inositol","1-((1-O-octadecyl-2-O-methylglycero)phospho)-3-deoxy-myo-inositol","C435044",0,0,2,0,4,0,0]
["1-((2-(acetylamino)-2-carboxyethyl)thio)-2-amino-3-oxo-8-carboxyl-3H-phenoxiazine","1-((2-(acetylamino)-2-carboxyethyl)thio)-2-amino-3-oxo-8-carboxyl-3H-phenoxiazine","C485864",2,0,0,0,0,0,0]
["1-((2-(acetylamino)-2-carboxyethyl)thio)-2-amino-3-oxo-8-formyl-3H-phenoxiazine","1-((2-(acetylamino)-2-carboxyethyl)thio)-2-amino-3-oxo-8-formyl-3H-phenoxiazine","C485863",2,0,0,0,0,0,0]
["1-((2-adamantyl)amino)acetyl-2-cyano-(S)-pyrrolidine, monohydrochloride","1-((2-adamantyl)amino)acetyl-2-cyano-(S)-pyrrolidine, monohydrochloride","C569631",0,0,2,0,0,0,0]
["1-((2-chloro-6-fluorobenzylidene)amino)-3-((5-methyl-2-oxo-2,3-dihydro-1H-indol-3-ylidene)amino)thiourea","1-((2-chloro-6-fluorobenzylidene)amino)-3-((5-methyl-2-oxo-2,3-dihydro-1H-indol-3-ylidene)amino)thiourea","C000616831",0,0,2,0,2,0,0]
["1-((2-di-p-tolylbismuthanophenyl)diazenyl)pyrrolidine","1-((2-di-p-tolylbismuthanophenyl)diazenyl)pyrrolidine","C583560",0,0,0,0,1,0,0]
["1-((2-hydroxyethoxy)methyl)-6-(phenylthio)thymine","1-((2-hydroxyethoxy)methyl)-6-(phenylthio)thymine","C061818",0,0,2,0,0,0,0]
["1-((2-hydroxyethyl)amino)-2-amino-1,2-dideoxyglucose triphenyltin(IV)","1-((2-hydroxyethyl)amino)-2-amino-1,2-dideoxyglucose triphenyltin(IV)","C574212",0,0,0,0,2,0,0]
["1-((2-hydroxyethyl)amino)-4-methyl-9H-thioxanthen-9-one","1-((2-hydroxyethyl)amino)-4-methyl-9H-thioxanthen-9-one","C550714",2,0,0,0,0,0,0]
["1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone","1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone","C053433",4,0,10,0,4,1,0]
["1-((3-chloromethyl)phenyl)-3-prop-2-ynylurea","1-((3-chloromethyl)phenyl)-3-prop-2-ynylurea","C574963",0,0,2,0,0,0,0]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C1412,B1412)","v":"1-((3-chlorophenyl)methyl)-1H-indole-3-carbinol"},"1-((3-chlorophenyl)methyl)-1H-indole-3-carbinol","C000595256",0,0,2,0,2,0,0]
["1-((4,5-bis(4-methoxyphenyl)-2-thiazoyl)carbonyl)-4-methylpiperazine","1-((4,5-bis(4-methoxyphenyl)-2-thiazoyl)carbonyl)-4-methylpiperazine","C085131",0,0,2,0,2,0,0]
["1-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride","1-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride","C092824",2,0,0,0,0,0,0]
["1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole","1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole","C090859",0,0,4,0,5,0,0]
["1-((5-((4-(2-methoxyphenyl)-1-piperazinyl)methyl)-2-furanyl)methyl)-2-azepinone","1-((5-((4-(2-methoxyphenyl)-1-piperazinyl)methyl)-2-furanyl)methyl)-2-azepinone","C096246",2,0,0,0,0,0,0]
["1-((5-((4-(2-methoxy-phenyl)-1-piperazinyl)methyl)-2-furanyl)methyl)-2-azocinone","1-((5-((4-(2-methoxy-phenyl)-1-piperazinyl)methyl)-2-furanyl)methyl)-2-azocinone","C096247",2,0,0,0,0,0,0]
["1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine","1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine","C484309",0,0,7,0,4,0,0]
["1-(1-(3,4,5-trimethoxyphenyl)vinyl)-1H-indol-4-amine","1-(1-(3,4,5-trimethoxyphenyl)vinyl)-1H-indol-4-amine","C000595116",0,0,2,0,0,0,0]
["1-(1-(imidazo(1,2-a)pyridin-6-yl)ethyl)-6-(1-methyl-1H-pyrazol-4-yl)-1H-(1,2,3)triazolo(4,5-b)pyrazine","1-(1-(imidazo(1,2-a)pyridin-6-yl)ethyl)-6-(1-methyl-1H-pyrazol-4-yl)-1H-(1,2,3)triazolo(4,5-b)pyrazine","C000593259",0,0,2,0,0,0,0]
["1-(1,4-benzodioxan-6-ylcarbonyl)piperidine","1-(1,4-benzodioxan-6-ylcarbonyl)piperidine","C443080",0,0,2,0,0,0,0]
["1-(1,4-dihydro-5,8-dihydroxy-1,4-dioxonaphthalen-2-yl)-4-methylpent-3-enylfuran-2-caroxylate","1-(1,4-dihydro-5,8-dihydroxy-1,4-dioxonaphthalen-2-yl)-4-methylpent-3-enylfuran-2-caroxylate","C512540",0,0,2,0,2,0,0]
["1-(10-pyrenedecanoyl)-2,3-dioleoylglycerol","1-(10-pyrenedecanoyl)-2,3-dioleoylglycerol","C046439",2,0,0,0,0,0,0]
["1-(13-hydroperoxy-9,11-octadecadienoyl)glycerol","1-(13-hydroperoxy-9,11-octadecadienoyl)glycerol","C426011",2,0,0,0,0,0,0]
["1-(1-acryloylpyrrolidin-3-yl)-7-(3-methyl-4-(4-methylpiperazin-1-yl)phenylamino)-3-phenyl-3,4-dihydropyrimido(4,5-d)pyrimidin-2(1H)-one","1-(1-acryloylpyrrolidin-3-yl)-7-(3-methyl-4-(4-methylpiperazin-1-yl)phenylamino)-3-phenyl-3,4-dihydropyrimido(4,5-d)pyrimidin-2(1H)-one","C587007",0,0,2,0,0,0,0]
["1-(1-butyl)-4-(2-oxo-1-benzimidazolinyl)piperidine","1-(1-butyl)-4-(2-oxo-1-benzimidazolinyl)piperidine","C120154",2,0,0,0,0,0,0]
["1-(1-carboxymethyl)-3-(2-hydroxypropyl)pyridinium betaine","1-(1-carboxymethyl)-3-(2-hydroxypropyl)pyridinium betaine","C058440",2,0,0,0,0,0,0]
["1-(1H-1,2,4-triazole)-2-(2,4-diflurophenyl)-3-(N-methyl-N-(4-iodo-benzyl)amino)-2-propanol","1-(1H-1,2,4-triazole)-2-(2,4-diflurophenyl)-3-(N-methyl-N-(4-iodo-benzyl)amino)-2-propanol","C518326",2,0,0,0,0,0,0]
["1-(1H-indol-3-yl)-3-(3H-indol-3-ylidene)propan-2-one","1-(1H-indol-3-yl)-3-(3H-indol-3-ylidene)propan-2-one","C547593",2,0,0,0,0,0,0]
["1-(1-hydroxy-5-isoquinolinesulfonyl)homopiperazine","1-(1-hydroxy-5-isoquinolinesulfonyl)homopiperazine","C110851",0,0,0,0,2,0,0]
["1-(1-hydroxy-6,6,9-trimethyl-6a,7,8,9,10,10a-hexahydro-6H-benzo(c)chromen-2-yl)ethanone","1-(1-hydroxy-6,6,9-trimethyl-6a,7,8,9,10,10a-hexahydro-6H-benzo(c)chromen-2-yl)ethanone","C575739",0,0,0,1,2,0,0]
["1-(1'-naphthyl)ethanol","1-(1'-naphthyl)ethanol","C521161",6,0,0,0,0,0,0]
["1-(1-naphthyl)ethylamine","1-(1-naphthyl)ethylamine","C055450",0,0,0,0,2,0,0]
["1-(1-naphthylmethyl)piperazine","1-(1-naphthylmethyl)piperazine","C511391",2,0,0,0,0,0,0]
["1-(2-((1H-indol-5-yl)oxy)ethyl)-4,4-dimethyl-6-(pyridin-3-yl)-1,2,3,4-tetrahydroquinoline","1-(2-((1H-indol-5-yl)oxy)ethyl)-4,4-dimethyl-6-(pyridin-3-yl)-1,2,3,4-tetrahydroquinoline","C000622280",0,0,2,0,0,0,0]
["1-(2-((3-(2-(1H-indol-3-yl)ethyl)-5-(propylthio)-3H-(1,2,3)triazolo(4,5-d)pyrimidin-7-yl)amino)ethyl)-3-(pyridin-3-yl)thiourea","1-(2-((3-(2-(1H-indol-3-yl)ethyl)-5-(propylthio)-3H-(1,2,3)triazolo(4,5-d)pyrimidin-7-yl)amino)ethyl)-3-(pyridin-3-yl)thiourea","C000623331",0,0,2,0,2,0,0]
["1-(2-((Z)-6-(2-(trifluoromethyl)phenyl)hexa-3-en-1,5-diynyl)phenyl)piperidin-2-one","1-(2-((Z)-6-(2-(trifluoromethyl)phenyl)hexa-3-en-1,5-diynyl)phenyl)piperidin-2-one","C545767",0,0,0,0,1,0,0]
["1-(2-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)ethoxycarbonyloxymethyl)-4-(N'-cyano-N''-(6-(4-chlorophenoxy)hexyl)-N-guanidino)pyridinium","1-(2-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)ethoxycarbonyloxymethyl)-4-(N'-cyano-N''-(6-(4-chlorophenoxy)hexyl)-N-guanidino)pyridinium","C541789",0,0,0,1,2,0,0]
["1-(2-(2-(4-pyridyl)-2-imidazoline-1-yl)ethyl)-3-(4-carboxyphenyl)urea","1-(2-(2-(4-pyridyl)-2-imidazoline-1-yl)ethyl)-3-(4-carboxyphenyl)urea","C033192",0,2,0,0,0,0,0]
["1-(2-(2,5-dimethoxyphenylthio)benzylidene)semicarbazide","1-(2-(2,5-dimethoxyphenylthio)benzylidene)semicarbazide","C541072",0,0,0,0,1,0,0]
["1-(2-(2-methoxyphenylamino)ethylamino)-3-(naphthalene-1-yloxy)propan-2-ol","1-(2-(2-methoxyphenylamino)ethylamino)-3-(naphthalene-1-yloxy)propan-2-ol","C586405",0,4,4,0,10,0,0]
["1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole","1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole","C063159",0,1,12,0,6,0,0]
["1-(2-(3,4-dimethoxyphenyl)ethyl)-4-(3-(3-iodophenyl)propyl)piperazine","1-(2-(3,4-dimethoxyphenyl)ethyl)-4-(3-(3-iodophenyl)propyl)piperazine","C515064",0,0,2,0,0,0,0]
["1-(2-(4-benzyl-4-hydroxypiperidin-1-yl)ethyl)-3-(2-methylquinolin-4-yl)urea","1-(2-(4-benzyl-4-hydroxypiperidin-1-yl)ethyl)-3-(2-methylquinolin-4-yl)urea","C493249",0,0,2,0,0,0,0]
["1-(2-(acridin-9-ylamino)ethyl)-1,3-dimethylthiourea","1-(2-(acridin-9-ylamino)ethyl)-1,3-dimethylthiourea","C471910",0,0,2,0,2,0,0]
["1-(2-(decylthio)ethyl)azacyclopentane-2-one","1-(2-(decylthio)ethyl)azacyclopentane-2-one","C075725",0,2,0,0,0,0,0]
["1-(2-(N-ethylamino)-5-fluorophenoxy)-2-(2-fluoro-4-aminophenoxy)ethane-N,N',N'-triacetic acid","1-(2-(N-ethylamino)-5-fluorophenoxy)-2-(2-fluoro-4-aminophenoxy)ethane-N,N',N'-triacetic acid","C093046",2,0,0,0,0,0,0]
["1-(2, 4-dichlorophenyl)-4, 5-dihydro-5-methyl-1H-pyrazole-3,5-dicarboxylic acid diethyl ester","1-(2, 4-dichlorophenyl)-4, 5-dihydro-5-methyl-1H-pyrazole-3,5-dicarboxylic acid diethyl ester","C555731",4,0,0,0,0,0,0]
["1-(2',3',4',6'-tetraacetylglucopyranosyloxyl)-1,4a,5,7a-tetrahydro-7-(acetomethyl)-cyclopentapyran-4-caroboxylic acid methyl ester","1-(2',3',4',6'-tetraacetylglucopyranosyloxyl)-1,4a,5,7a-tetrahydro-7-(acetomethyl)-cyclopentapyran-4-caroboxylic acid methyl ester","C469218",0,0,0,0,4,0,0]
["1-(2,3,4-trideoxy-2-methylene-beta-d-glycero-hex-3-enopyranosyl)thymine","1-(2,3,4-trideoxy-2-methylene-beta-d-glycero-hex-3-enopyranosyl)thymine","C522701",0,0,2,0,0,0,0]
["1-(2,3-dichloro-4-((3-(4-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)methoxy)phenyl)-2-methylenebutan-1-one","1-(2,3-dichloro-4-((3-(4-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)methoxy)phenyl)-2-methylenebutan-1-one","C587438",0,0,0,0,2,0,0]
["1-(2,3-dichloro-4-((3-phenyl-1,2,4-oxadiazol-5-yl)methoxy)phenyl)-2-methylenebutan-1-one","1-(2,3-dichloro-4-((3-phenyl-1,2,4-oxadiazol-5-yl)methoxy)phenyl)-2-methylenebutan-1-one","C587437",0,0,0,0,2,0,0]
["1-(2,3-dichlorobenzoyl)-5-methoxy-2-methyl-(2-(mopholin-4-yl)ethyl)-1H-indole","1-(2,3-dichlorobenzoyl)-5-methoxy-2-methyl-(2-(mopholin-4-yl)ethyl)-1H-indole","C463040",0,0,2,0,0,0,0]
["1-(2,4-diamino phenylazo)naphthalene","1-(2,4-diamino phenylazo)naphthalene","C568744",2,0,0,0,0,0,0]
["1-(2,4-dichlorobenzyl)indazole-3-carbohydrazide","1-(2,4-dichlorobenzyl)indazole-3-carbohydrazide","C432482",0,0,2,0,0,0,0]
["1-(2,4-dimethoxyphenyl)-3-(1-methylindolyl)propenone","1-(2,4-dimethoxyphenyl)-3-(1-methylindolyl)propenone","C546292",0,0,2,0,2,0,0]
["1-(2',4'-dinitroaminophenyl)-4,4,6-trimethyl-1,4-dihydropyrimidine-2-thiol","1-(2',4'-dinitroaminophenyl)-4,4,6-trimethyl-1,4-dihydropyrimidine-2-thiol","C553037",4,0,0,0,0,0,0]
["1-(2,6-dichlorophenyl)indolin-2-one","1-(2,6-dichlorophenyl)indolin-2-one","C456899",2,0,0,0,0,0,0]
["1-(2',6'-difluorophenyl)-1H,3H-thiazolo(3,4-a)benzimidazole","1-(2',6'-difluorophenyl)-1H,3H-thiazolo(3,4-a)benzimidazole","C073244",2,0,0,0,3,0,0]
["1-(2,6-dihydroxy-4-methoxyphenyl)-2-(4-hydroxyphenyl)ethanone","1-(2,6-dihydroxy-4-methoxyphenyl)-2-(4-hydroxyphenyl)ethanone","C000593722",0,0,0,0,1,0,0]
["1-(2,6-dimethylphenoxy)-2-(3,4-dimethoxyphenylethylamino)propane","1-(2,6-dimethylphenoxy)-2-(3,4-dimethoxyphenylethylamino)propane","C057485",2,0,0,0,0,0,0]
["1-(2,7-difluoro-6-hydroxy-4,5-bis(1,2,3-dithioarsolan-2-yl)-3-oxo-3H-xanthen-9-yl)-4-oxo-4H-quinolizine-3-carboxylic Acid","1-(2,7-difluoro-6-hydroxy-4,5-bis(1,2,3-dithioarsolan-2-yl)-3-oxo-3H-xanthen-9-yl)-4-oxo-4H-quinolizine-3-carboxylic Acid","C000592216",2,0,0,0,0,0,0]
["1-(2-aminoethyl-(6-hydrazinopyridine-3-carbamidyl))-3,5-bis-(2-fluorobenzylidene)-4-piperidone","1-(2-aminoethyl-(6-hydrazinopyridine-3-carbamidyl))-3,5-bis-(2-fluorobenzylidene)-4-piperidone","C571719",0,0,2,0,0,0,0]
["1-(2-bromo-3,4,5-trimethoxyphenyl)-3-(3-hydroxy-4-methoxyphenylamino)prop-2-en-1-one","1-(2-bromo-3,4,5-trimethoxyphenyl)-3-(3-hydroxy-4-methoxyphenylamino)prop-2-en-1-one","C575279",0,0,2,0,2,0,0]
["1-(2-bromobenzyloxy)-4-bromo-2-benzylidene rhodanine","1-(2-bromobenzyloxy)-4-bromo-2-benzylidene rhodanine","C550529",0,0,1,0,1,0,0]
["1-(2-bromoethyl)-6-oxyl-5,5,7,7-tetramethyltetrahydroimidazo(1,5-b)(1,2,4)oxadiazol-2-one","1-(2-bromoethyl)-6-oxyl-5,5,7,7-tetramethyltetrahydroimidazo(1,5-b)(1,2,4)oxadiazol-2-one","C527426",2,0,0,0,0,0,0]
["1-(2'-carboxyethyl)-3-hydroxy-2-methyl-4-pyridinone","1-(2'-carboxyethyl)-3-hydroxy-2-methyl-4-pyridinone","C415337",2,0,0,0,0,0,0]
["1-(2-carboxyethyl)adenine","1-(2-carboxyethyl)adenine","C026369",2,0,0,0,0,0,0]
["1-(2-chloro-2-phenylethyl)-3-(4-methylphenyl)-1H-pyrazolo(3,4-d)pyrimidin-4-amine","1-(2-chloro-2-phenylethyl)-3-(4-methylphenyl)-1H-pyrazolo(3,4-d)pyrimidin-4-amine","C000601372",0,0,2,0,0,0,0]
["1-(2-chloro-2-phenylethyl)-6-(methylthio)-N-(2-phenylethyl)-1H-pyrazolo(3,4-d)pyrimidin-4-amine","1-(2-chloro-2-phenylethyl)-6-(methylthio)-N-(2-phenylethyl)-1H-pyrazolo(3,4-d)pyrimidin-4-amine","C531241",0,0,0,0,2,0,0]
["1-(2-chloro-6-fluorophenyl)-5-methylindolin-2-one","1-(2-chloro-6-fluorophenyl)-5-methylindolin-2-one","C555769",2,0,0,0,0,0,0]
["1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one","1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one","C569107",0,0,1,0,2,0,0]
["1-(2-chloroethyl)-1-nitrosourea","1-(2-chloroethyl)-1-nitrosourea","C017139",2,0,2,0,1,0,0]
["1-(2-chloroethyl)-3-(2-(5-fluoro-3-oxobenzoselenazol-2(3H)-yl)ethyl)-1-nitrosourea","1-(2-chloroethyl)-3-(2-(5-fluoro-3-oxobenzoselenazol-2(3H)-yl)ethyl)-1-nitrosourea","C000613750",0,0,2,0,0,0,0]
["1-(2-chloroethyl)-3-(2-(dimethylaminosulfonyl)ethyl)-1-nitrosourea","1-(2-chloroethyl)-3-(2-(dimethylaminosulfonyl)ethyl)-1-nitrosourea","C052991",6,0,0,0,0,0,0]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C1476,B1476)","v":"1-(2-chloroimidazo(1,2-a)pyridin-3-ylsulfonyl)-3-(4,6-dimethoxypyrimidin-2-yl)urea"},"1-(2-chloroimidazo(1,2-a)pyridin-3-ylsulfonyl)-3-(4,6-dimethoxypyrimidin-2-yl)urea","C433346",2,0,0,0,0,0,0]
["1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","C472829",0,1,15,0,35,0,0]
["1-(2-fluoro-2-deoxy-3,5-O-dibenzoylarabinofuranosyl)-5-bromouracil","1-(2-fluoro-2-deoxy-3,5-O-dibenzoylarabinofuranosyl)-5-bromouracil","C470853",0,0,1,0,0,0,0]
["1-(2-fluoro-2-deoxyarabinofuranosyl)-5-bromouracil","1-(2-fluoro-2-deoxyarabinofuranosyl)-5-bromouracil","C470854",0,0,1,0,0,0,0]
["1-(2-fluoro-4-(1H-pyrazol-1-yl)phenyl)-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one","1-(2-fluoro-4-(1H-pyrazol-1-yl)phenyl)-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one","C000594749",0,1,0,0,0,0,0]
["1-(2-guanidinoethyl)-4-(2-hydroxyethyl)-1,4,7-triazacyclononane hydrochloride","1-(2-guanidinoethyl)-4-(2-hydroxyethyl)-1,4,7-triazacyclononane hydrochloride","C518837",2,0,0,0,0,0,0]
["1-(2-hydroxy-2-methylpropyl)-N-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide","1-(2-hydroxy-2-methylpropyl)-N-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide","C530596",0,0,2,0,2,0,0]
["1-(2-hydroxy-3- methyl 4,5-dimethoxyphenyl)-3-(1H-pyrrol-2-yl)-2-propen-1-one","1-(2-hydroxy-3- methyl 4,5-dimethoxyphenyl)-3-(1H-pyrrol-2-yl)-2-propen-1-one","C000608030",0,0,0,0,2,0,0]
["1-(2-hydroxy-3-methoxybenzaldehyde)-4-aminosalicylhydrazone","1-(2-hydroxy-3-methoxybenzaldehyde)-4-aminosalicylhydrazone","C572874",2,0,2,0,2,0,0]
["1-(2-hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione","1-(2-hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione","C506624",0,0,2,0,8,0,0]
["1-(2''-hydroxycyclohexyl)-3'-aminopropyl-4-(3'-aminopropyl)piperazine","1-(2''-hydroxycyclohexyl)-3'-aminopropyl-4-(3'-aminopropyl)piperazine","C531920",2,0,0,0,0,0,0]
["1-(2-hydroxyethyl)-3-(6-(2-methoxyphenyl)benzo(d)thiazol-2-yl)urea","1-(2-hydroxyethyl)-3-(6-(2-methoxyphenyl)benzo(d)thiazol-2-yl)urea","C000589392",0,0,2,0,2,0,0]
["1-(2-hydroxyethyl)-3,5,7-triaza-1-azoniatricyclo(3.3.1.1(3,7))decane bromide","1-(2-hydroxyethyl)-3,5,7-triaza-1-azoniatricyclo(3.3.1.1(3,7))decane bromide","C574188",0,0,0,0,2,0,0]
["1-(2-methoxy-5-nitrophenylazo)-2-hydroxy-3-(3-nitrophenylcarbamoyl)naphthalene","1-(2-methoxy-5-nitrophenylazo)-2-hydroxy-3-(3-nitrophenylcarbamoyl)naphthalene","C506598",6,0,0,0,0,0,0]
["1-(2-methoxybenzylidene)-4-phenylthiosemicarbazide","1-(2-methoxybenzylidene)-4-phenylthiosemicarbazide","C538805",2,0,0,0,0,0,0]
["1-(2-methoxyphenyl)piperazine","1-(2-methoxyphenyl)piperazine","C040083",0,0,0,0,0,2,0]
["1-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea","1-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea","C420062",2,0,0,0,0,0,0]
["1-(2-methylphenyl)-4-methylamino-6-methyl-2,3-dihydropyrrolo(3,2-c)quinoline","1-(2-methylphenyl)-4-methylamino-6-methyl-2,3-dihydropyrrolo(3,2-c)quinoline","C069657",0,0,2,0,0,0,0]
["1-(2-naphthyl)-3-methyl-5-pyrazolone","1-(2-naphthyl)-3-methyl-5-pyrazolone","C527199",2,0,0,0,0,0,0]
["1-(2-nitro-1-imidazolyl)-3-aziridino-2-propanol","1-(2-nitro-1-imidazolyl)-3-aziridino-2-propanol","C041712",14,0,0,1,0,0,0]
["1-(2-nitrophenyl)ethyl sulfate","1-(2-nitrophenyl)ethyl sulfate","C473956",2,0,0,0,0,0,0]
["1-(2-nitrophenyl)-ethylhexadecylsulfonate","1-(2-nitrophenyl)-ethylhexadecylsulfonate","C000614029",2,0,0,0,0,0,0]
["1-(2-nitrophenyl)ethylpyranine","1-(2-nitrophenyl)ethylpyranine","C466316",2,0,0,0,0,0,0]
["1-(2-pyridylazo)-2-naphthol","1-(2-pyridylazo)-2-naphthol","C041728",18,0,0,0,0,0,0]
["1-(2-pyridylmethylidene)-5-(salicylidene)thiocarbonylhydrazone","1-(2-pyridylmethylidene)-5-(salicylidene)thiocarbonylhydrazone","C049366",2,0,0,0,0,0,0]
["1-(2-pyrrolidinylcarbonyl)-2-pyrrolidinylboronic acid","1-(2-pyrrolidinylcarbonyl)-2-pyrrolidinylboronic acid","C083014",2,0,0,0,0,0,0]
["1-(2-thiazolylazo)-2-naphthol","1-(2-thiazolylazo)-2-naphthol","C054556",2,0,0,0,0,0,0]
["1-(2-thiazolylazo)-p-cresol","1-(2-thiazolylazo)-p-cresol","C496275",2,0,0,0,0,0,0]
["1-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea","1-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea","C582286",0,0,2,0,2,0,0]
["1-(3-((4-(4-acetylphenyl)piperazin-1-yl)methyl)-4-hydroxy-5-methoxyphenyl)-3-(pyridin-3-yl)prop-2-en-1-one","1-(3-((4-(4-acetylphenyl)piperazin-1-yl)methyl)-4-hydroxy-5-methoxyphenyl)-3-(pyridin-3-yl)prop-2-en-1-one","C559076",0,0,0,0,2,0,0]
["1-(3-(1H-imidazol-1-yl)propyl)-4-benzoyl-5-(4-bromophenyl)-3-isopropoxy-1H-pyrrol-2(5H)-one","1-(3-(1H-imidazol-1-yl)propyl)-4-benzoyl-5-(4-bromophenyl)-3-isopropoxy-1H-pyrrol-2(5H)-one","C577939",0,0,2,0,2,0,0]
["1-(3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo(4,5)cyclohepta(1,2-b)pyridin-7-yl)-N-(pyridin-2-ylmethyl)methanesulfonamide","1-(3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo(4,5)cyclohepta(1,2-b)pyridin-7-yl)-N-(pyridin-2-ylmethyl)methanesulfonamide","C581209",0,0,2,0,0,0,0]
["1-(3-(2-(1-benzothiophen-5-yl) ethoxy) propyl)-3-azetidinol maleate","1-(3-(2-(1-benzothiophen-5-yl) ethoxy) propyl)-3-azetidinol maleate","C503102",0,1,2,0,2,0,0]
["1-(3-(2H-1,2,3-triazol-2-yl)phenyl)-N-6-(2-aminocyclohexyl)-1H-pyrazolo(3,4-b)pyrazine-3,6-diamine","1-(3-(2H-1,2,3-triazol-2-yl)phenyl)-N-6-(2-aminocyclohexyl)-1H-pyrazolo(3,4-b)pyrazine-3,6-diamine","C000620493",0,0,2,0,0,0,0]
["1-(3-(2-methylpyridin-4-yl)-1H-pyrazolo(4,3-c)pyridin-6-yl)-3-(1-phenylethyl)urea","1-(3-(2-methylpyridin-4-yl)-1H-pyrazolo(4,3-c)pyridin-6-yl)-3-(1-phenylethyl)urea","C000619474",0,0,2,0,0,0,0]
["1-(3-(3-(3,4,5-trimethoxybenzoyl)-1H-pyrrol-1-yl)phenyl)guanidine","1-(3-(3-(3,4,5-trimethoxybenzoyl)-1H-pyrrol-1-yl)phenyl)guanidine","C000594995",0,0,2,0,0,0,0]
["1-(3-(3,4,5-trimethoxyphenyl)acryloyl)piperidin-2-one","1-(3-(3,4,5-trimethoxyphenyl)acryloyl)piperidin-2-one","C000601731",0,0,2,0,2,0,0]
["1-(3-(3-aminopropylamino)-2-hydroxylpropylamino)-9,10-anthraquinone","1-(3-(3-aminopropylamino)-2-hydroxylpropylamino)-9,10-anthraquinone","C579330",0,0,0,0,2,0,0]
["1-(3-(4-aminobutylamino)-2-hydroxylpropylamino)-9,10-anthraquinone","1-(3-(4-aminobutylamino)-2-hydroxylpropylamino)-9,10-anthraquinone","C579331",0,0,0,0,2,0,0]
["1-(3-(4-methoxyphenyl)acryloyl)pyrrolidin-2-one","1-(3-(4-methoxyphenyl)acryloyl)pyrrolidin-2-one","C000601732",0,0,2,0,2,0,0]
["1-(3-(4-tert-butylphenoxy)propyl)piperidine","1-(3-(4-tert-butylphenoxy)propyl)piperidine","C000608066",2,0,0,0,0,0,0]
["1-(3-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)propyl)-4-(2-(3-fluorophenyl)ethyl)piperazine","1-(3-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)propyl)-4-(2-(3-fluorophenyl)ethyl)piperazine","C117663",2,0,0,0,0,0,0]
["1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea","1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea","C575620",0,0,3,0,0,0,0]
["1-(3',4',5'-trimethoxy)phenylnaphtho(2,1b)furan","1-(3',4',5'-trimethoxy)phenylnaphtho(2,1b)furan","C509743",0,0,2,0,0,0,0]
["1-(3',4',5'-trimethoxyphenyl)-2-nitroethylene","1-(3',4',5'-trimethoxyphenyl)-2-nitroethylene","C462659",2,0,0,0,0,0,0]
["1-(3',4',5'-trimethoxyphenyl)-3-(3'',4''-dimethoxy-2'-hydroxyphenyl)propane","1-(3',4',5'-trimethoxyphenyl)-3-(3'',4''-dimethoxy-2'-hydroxyphenyl)propane","C552420",0,0,0,0,2,0,0]
["1-(3,4,5-trimethoxyphenyl)-5-(4-ethoxyphenyl)-1H-1,2,4-triazole","1-(3,4,5-trimethoxyphenyl)-5-(4-ethoxyphenyl)-1H-1,2,4-triazole","C550171",0,0,0,0,1,0,0]
["1-(3,4,5-trimethoxyphenyl)-5-(4-ethoxyphenyl)-1H-tetrazole","1-(3,4,5-trimethoxyphenyl)-5-(4-ethoxyphenyl)-1H-tetrazole","C570919",0,0,2,0,2,0,0]
["1-(3',4'-dichloro-2-fluoro(1,1'-biphenyl)-4-yl)cyclopropanecarboxylic acid","1-(3',4'-dichloro-2-fluoro(1,1'-biphenyl)-4-yl)cyclopropanecarboxylic acid","C522246",0,1,0,0,4,0,0]
["1-(3,4-dichlorophenyl)acetyl-2-(1-pyrrolidinyl)methylpiperidine","1-(3,4-dichlorophenyl)acetyl-2-(1-pyrrolidinyl)methylpiperidine","C454101",0,0,0,0,2,0,0]
["1-(3,4-dihydroxyphenyl)-2-((1-mesityl-1H-imidazo(4,5-c)pyridin-2-yl)thio)ethanone","1-(3,4-dihydroxyphenyl)-2-((1-mesityl-1H-imidazo(4,5-c)pyridin-2-yl)thio)ethanone","C000595838",0,0,2,0,0,0,0]
["1-(3,4-dihydroxyphenyl)-2-thiocyanate-ethanone","1-(3,4-dihydroxyphenyl)-2-thiocyanate-ethanone","C527742",0,0,0,0,6,0,0]
["1-(3,4-dihydroxyphenyl)-3-(2-methoxyphenyl)prop-2-en-1-one","1-(3,4-dihydroxyphenyl)-3-(2-methoxyphenyl)prop-2-en-1-one","C000603962",0,0,0,0,2,0,0]
["1-(3,4-dihydroxystyryl)-3-(4-hydroxyphenethyl)urea","1-(3,4-dihydroxystyryl)-3-(4-hydroxyphenethyl)urea","C550461",0,0,2,0,0,0,0]
["1-(3,4-dimethoxybenzyl)-5-(2-(methylsulfonyl)-6-(trifluoromethyl)pyrimidin-4-yl)pyridin-2(1H)-one","1-(3,4-dimethoxybenzyl)-5-(2-(methylsulfonyl)-6-(trifluoromethyl)pyrimidin-4-yl)pyridin-2(1H)-one","C000622061",0,0,2,0,2,0,0]
["1-(3,4-dimethoxyphenyl)-3-(9H-pyrido(3,4-b)indol-1-yl)prop-2-en-1-one","1-(3,4-dimethoxyphenyl)-3-(9H-pyrido(3,4-b)indol-1-yl)prop-2-en-1-one","C000622459",0,0,0,0,2,0,0]
["1-(3,5-bis(trifluoromethyl)phenyl)-3-(4-bromo-2-(1H-tetrazol-5-yl)phenyl)thiourea","1-(3,5-bis(trifluoromethyl)phenyl)-3-(4-bromo-2-(1H-tetrazol-5-yl)phenyl)thiourea","C524410",0,0,0,0,2,0,0]
["1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl-)-1-pentanone","1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl-)-1-pentanone","C055365",2,0,0,0,0,0,0]
["1-(3',5'-dihydroxyphenoxy)-7-(2'',4'',6''-trihydroxyphenoxy)-2,4,9-trihydroxydibenzo-1,4,-dioxin","1-(3',5'-dihydroxyphenoxy)-7-(2'',4'',6''-trihydroxyphenoxy)-2,4,9-trihydroxydibenzo-1,4,-dioxin","C540360",0,0,2,0,0,0,0]
["1-(3'-aminopropyl)-3-hydroxy-2-methyl-4-pyridinone","1-(3'-aminopropyl)-3-hydroxy-2-methyl-4-pyridinone","C415336",2,0,0,0,0,0,0]
["1-(3-aminopropyl)imidazole","1-(3-aminopropyl)imidazole","C515394",6,0,0,0,0,0,0]
["1-(3-biphenyl-4-ylbutyl)piperidine","1-(3-biphenyl-4-ylbutyl)piperidine","C584299",0,0,2,0,0,0,0]
["1-(3-chloro-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone","1-(3-chloro-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone","C055364",0,0,6,0,0,0,0]
["1-(3-chlorophenyl)piperazine","1-(3-chlorophenyl)piperazine","C015068",2,0,0,0,0,0,0]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C1540,B1540)","v":"1-(3-cyano-4-neopentyloxyphenyl)pyrazole-4-carboxylic acid"},"1-(3-cyano-4-neopentyloxyphenyl)pyrazole-4-carboxylic acid","C433950",0,0,2,0,0,0,0]
["1-(3-hydroxy-6-(hydroxymethyl)-4-oxopyridyl)-2-ethanesulfonic acid","1-(3-hydroxy-6-(hydroxymethyl)-4-oxopyridyl)-2-ethanesulfonic acid","C085370",2,0,0,0,0,0,0]
["1-(3-sulfonatopropyl)-4-(beta)(2-(di-n-butylamino)-6-naphthylvinyl)pyridinium betaine","1-(3-sulfonatopropyl)-4-(beta)(2-(di-n-butylamino)-6-naphthylvinyl)pyridinium betaine","C050019",2,0,0,0,0,0,0]
["1-(3-trifluoromethylphenyl)piperazine","1-(3-trifluoromethylphenyl)piperazine","C018406",2,0,2,0,2,0,0]
["1-(4-((1H-pyrazolo(3,4-d)pyrimidin-4-yl)oxy)-2-fluorophenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea","1-(4-((1H-pyrazolo(3,4-d)pyrimidin-4-yl)oxy)-2-fluorophenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea","C000593421",0,0,1,1,0,0,0]
["1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno(3,2-d)pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one","1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno(3,2-d)pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one","C569670",0,0,2,0,2,0,0]
["1-(4-((3-(4-methylpiperazin-1-yl)propyl)amino)benzyl)-5-(trifluoromethyl)pyridin-2(1H)-one","1-(4-((3-(4-methylpiperazin-1-yl)propyl)amino)benzyl)-5-(trifluoromethyl)pyridin-2(1H)-one","C000607330",0,0,2,0,0,0,0]
["1-(4-((4-(dimethylamino)piperidin-1-yl)carbonyl)phenyl)-3-(4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl)urea","1-(4-((4-(dimethylamino)piperidin-1-yl)carbonyl)phenyl)-3-(4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl)urea","C549060",0,0,14,0,8,0,0]
["1-(4-(1H-1,2,4-triazol-1-yl)benzylidene)-2-(4-(4-nitrophenyl)thiazol-2-yl)hydrazine","1-(4-(1H-1,2,4-triazol-1-yl)benzylidene)-2-(4-(4-nitrophenyl)thiazol-2-yl)hydrazine","C000596312",0,0,2,0,0,0,0]
["1-(4-(1H-benzo(d)imidazol-2-yl)phenyl)-9H-pyrido(3,4-b)indole","1-(4-(1H-benzo(d)imidazol-2-yl)phenyl)-9H-pyrido(3,4-b)indole","C000616874",0,0,2,0,0,0,0]
["1-(4-(1H-pyrazolo(3,4-d)pyrimidin-4-yloxy)-3-fluorophenyl)-3-(5-tert-butylisoxazol-3-yl)urea","1-(4-(1H-pyrazolo(3,4-d)pyrimidin-4-yloxy)-3-fluorophenyl)-3-(5-tert-butylisoxazol-3-yl)urea","C000610642",0,0,2,0,2,0,0]
["1-(4-(1H-pyrazolo(3,4-d)pyrimidin-4-yloxy)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea","1-(4-(1H-pyrazolo(3,4-d)pyrimidin-4-yloxy)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea","C582543",0,0,4,0,2,0,0]
["1-(4-(2-ethoxy-4-methyl-1H-pyrrol-1-yl)-3-hydroxy-2,2-dimethylchroman-6-yl)-3-phenylurea","1-(4-(2-ethoxy-4-methyl-1H-pyrrol-1-yl)-3-hydroxy-2,2-dimethylchroman-6-yl)-3-phenylurea","C569385",0,0,2,0,2,0,0]
["1-(4-(2-fluoroethoxy)benzyl)-5-(1-(2-methoxymethylpyrrolidinyl)sulfonyl)isatin","1-(4-(2-fluoroethoxy)benzyl)-5-(1-(2-methoxymethylpyrrolidinyl)sulfonyl)isatin","C516218",0,0,0,0,2,0,0]
["1-(4-(4-(aminosulfonyl)phenyl)-1H-1,2,3-triazole)-2,3,4-tri-O-acetyl-6-O-(((bis((2-((2,2-dimethylpropionyl)sulfanyl)ethoxy))phosphoryloxy)ethyl))glucopyranoside","1-(4-(4-(aminosulfonyl)phenyl)-1H-1,2,3-triazole)-2,3,4-tri-O-acetyl-6-O-(((bis((2-((2,2-dimethylpropionyl)sulfanyl)ethoxy))phosphoryloxy)ethyl))glucopyranoside","C000603805",2,0,0,0,0,0,0]
["1-(4-(4-fluorophenyl)piperazine-1-yl)-3-(2-oxopyrrolidin-1-yl)propane","1-(4-(4-fluorophenyl)piperazine-1-yl)-3-(2-oxopyrrolidin-1-yl)propane","C439505",4,0,0,0,0,0,0]
["1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one","1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one","C553294",0,0,2,1,2,0,0]
["1-(4-(5,6,7,8-tetrahydronaphthyloxy)phenyl)-1-hydroxymethylphosphonic acid","1-(4-(5,6,7,8-tetrahydronaphthyloxy)phenyl)-1-hydroxymethylphosphonic acid","C116525",0,0,0,0,0,1,0]
["1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone","1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone","C517943",0,0,29,1,18,0,0]
["1-(4-(6-chloro-7-(2-fluorophenyl)quinazolin-4-yl)piperazin-1-yl)prop-2-en-1-one","1-(4-(6-chloro-7-(2-fluorophenyl)quinazolin-4-yl)piperazin-1-yl)prop-2-en-1-one","C000623134",0,0,0,0,2,0,0]
["1-(4-(benzo(d)(1,3)dioxol-5-ylmethyl)piperazin-1-yl)-5-(1,2-dithiolan-3-yl)pentan-1-one","1-(4-(benzo(d)(1,3)dioxol-5-ylmethyl)piperazin-1-yl)-5-(1,2-dithiolan-3-yl)pentan-1-one","C569199",0,0,2,0,0,0,0]
["1-(4'-(dimethylamino)-5-hydroxy-(1,1'-biphenyl)-3-yl)-4-(2-(2-ethoxyphenyl)hydrazono)-3-methyl-1H-pyrazol-5(4H)-one","1-(4'-(dimethylamino)-5-hydroxy-(1,1'-biphenyl)-3-yl)-4-(2-(2-ethoxyphenyl)hydrazono)-3-methyl-1H-pyrazol-5(4H)-one","C000598567",0,0,0,0,2,0,0]
["1-(4-(ferrocenyl ethynyl)phenyl)-1-ethanone","1-(4-(ferrocenyl ethynyl)phenyl)-1-ethanone","C520373",2,0,0,0,0,0,0]
["1-(4-(furo(2,3-b)quinolin-4-ylamino)phenyl)ethanone","1-(4-(furo(2,3-b)quinolin-4-ylamino)phenyl)ethanone","C510259",0,0,3,0,2,0,0]
["1-(4-(furo(2,3-b)quinolin-4-ylamino)phenyl)ethanone O-2-aminoethyloxime","1-(4-(furo(2,3-b)quinolin-4-ylamino)phenyl)ethanone O-2-aminoethyloxime","C561229",0,0,0,0,1,0,0]
["1-(4-(trimethylamino)phenyl)-6-phenylhexa-1,3,5-triene","1-(4-(trimethylamino)phenyl)-6-phenylhexa-1,3,5-triene","C033628",6,0,0,0,1,0,0]
["1-(4,4-bis(4-fluorophenyl)butyl)-4-(4-fluorophenoxy)-1,2,3,6-tetrahydropyridine","1-(4,4-bis(4-fluorophenyl)butyl)-4-(4-fluorophenoxy)-1,2,3,6-tetrahydropyridine","C049269",0,1,0,0,0,0,0]
["1-(4,7-dimethylbenzothiazol-2-yl)-3-(3-fluoro-4-(6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinolin-4-yloxy)phenyl)urea","1-(4,7-dimethylbenzothiazol-2-yl)-3-(3-fluoro-4-(6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinolin-4-yloxy)phenyl)urea","C000614530",0,0,2,0,0,0,0]
["1-(4-aminophenyl)methyl-3-(3-nitrophenyl)-1,3-dihydroimidazo(4,5-b)pyridine-2-one","1-(4-aminophenyl)methyl-3-(3-nitrophenyl)-1,3-dihydroimidazo(4,5-b)pyridine-2-one","C414810",0,0,0,0,4,0,0]
["1-(4-bromoacetamidobenzyl)EDTA","1-(4-bromoacetamidobenzyl)EDTA","C042007",4,0,0,0,0,0,0]
["1-(4-bromophenyl)ethanol","1-(4-bromophenyl)ethanol","C522554",2,0,0,0,0,0,0]
["1-(4'-carboxyethyl)-6-diphenyl-1,3,5-hexatriene","1-(4'-carboxyethyl)-6-diphenyl-1,3,5-hexatriene","C037385",2,0,0,0,0,0,0]
["1-(4-carboxyphenyl)-3,3-dimethyltriazene","1-(4-carboxyphenyl)-3,3-dimethyltriazene","C030838",4,0,0,0,0,0,0]
["1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2-cyano-4-hydroxyphenyl)urea","1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2-cyano-4-hydroxyphenyl)urea","C572620",0,0,2,1,2,0,0]
["1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(6-(3-((2-(piperidin-1-yl)ethylamino)methyl)-1H-indazol-1-yl)pyidin-3-yl)urea","1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(6-(3-((2-(piperidin-1-yl)ethylamino)methyl)-1H-indazol-1-yl)pyidin-3-yl)urea","C000608247",0,0,2,1,2,0,0]
["1-(4-chlorophenyl)-3-(3-((2,4-dichlorophenyl)amino)-1,1-dioxidobenzo(d)isothiazol-5-yl)urea","1-(4-chlorophenyl)-3-(3-((2,4-dichlorophenyl)amino)-1,1-dioxidobenzo(d)isothiazol-5-yl)urea","C000591016",0,0,2,0,0,0,0]
["1-(4-chlorophenyl)-3-(3-(4-chlorophenyl)-5,5-dimethyl-1-(3-(5-nitrofuran-2-yl)allyldienehydrazinocarbonylmethyl)-2-oxoimidazolidin-4-yl)-1-hydroxyurea","1-(4-chlorophenyl)-3-(3-(4-chlorophenyl)-5,5-dimethyl-1-(3-(5-nitrofuran-2-yl)allyldienehydrazinocarbonylmethyl)-2-oxoimidazolidin-4-yl)-1-hydroxyurea","C492847",0,0,2,0,0,0,0]
["1-(4-chlorophenyl)-4,4,4-trifluoro-3-hydroxy-2-buten-1-one","1-(4-chlorophenyl)-4,4,4-trifluoro-3-hydroxy-2-buten-1-one","C000622919",2,0,0,0,0,0,0]
["1-(4-chlorophenyl)imidazole","1-(4-chlorophenyl)imidazole","C525744",0,0,0,0,0,1,0]
["1-(4-Cl-benzyl)-3-Cl-4-(CF3-phenylamino)-1H-pyrrol-2.5-dione","1-(4-Cl-benzyl)-3-Cl-4-(CF3-phenylamino)-1H-pyrrol-2.5-dione","C550019",0,0,2,0,2,0,0]
["1-(4-dimethylaminomethylphenyl)-8,9-dihydro-7H-2,7,9a-benzo(cd)azulen-6-one","1-(4-dimethylaminomethylphenyl)-8,9-dihydro-7H-2,7,9a-benzo(cd)azulen-6-one","C479234",0,0,2,0,2,0,0]
["1-(4-fluorophenyl)-2-oxo-N-(4-((2-(thiophen-3-yl)-3H-imidazo(4,5-b)pyridin-7-yl)oxy)phenyl)-1,2-dihydropyridine-3-carboxamide","1-(4-fluorophenyl)-2-oxo-N-(4-((2-(thiophen-3-yl)-3H-imidazo(4,5-b)pyridin-7-yl)oxy)phenyl)-1,2-dihydropyridine-3-carboxamide","C575180",0,0,2,0,0,0,0]
["1-(4-fluorophenyl)-4-(4-(5-fluoro-2-pyrimidinyl)-1-piperazinyl)butan-1-one","1-(4-fluorophenyl)-4-(4-(5-fluoro-2-pyrimidinyl)-1-piperazinyl)butan-1-one","C081146",2,0,0,0,0,0,0]
["1-(4-hydroxy-3-((4-(4-(3-(pyridin-3-yl)acryloyl)phenyl)piperazin-1-yl)methyl)phenyl)-3-(pyridin-3-yl)prop-2-en-1-one","1-(4-hydroxy-3-((4-(4-(3-(pyridin-3-yl)acryloyl)phenyl)piperazin-1-yl)methyl)phenyl)-3-(pyridin-3-yl)prop-2-en-1-one","C559075",0,0,0,0,1,0,0]
["1-(4-hydroxy-3-methoxyphenyl)-7-(3,4-dihydroxyphenyl)-4E-en-3-heptanone","1-(4-hydroxy-3-methoxyphenyl)-7-(3,4-dihydroxyphenyl)-4E-en-3-heptanone","C539887",0,0,0,0,2,0,0]
["1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium) propane dibromide","1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium) propane dibromide","C481758",0,0,0,0,2,0,0]
["1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)butane","1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)butane","C488676",0,0,0,0,2,0,0]
["1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene","1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene","C090768",2,0,0,0,0,0,0]
["1-(4-hydroxyphenyl)-2-n-propyl-1,2-dicarba-closo-dodecaborane","1-(4-hydroxyphenyl)-2-n-propyl-1,2-dicarba-closo-dodecaborane","C000597991",0,0,2,0,0,0,0]
["1-(4-iodophenylsulfonyl)-N-(1-oxo-3-phenylpropan-2-yl)pyrrolidine-2-carboxamide","1-(4-iodophenylsulfonyl)-N-(1-oxo-3-phenylpropan-2-yl)pyrrolidine-2-carboxamide","C513860",0,0,2,0,0,0,0]
["1-(4-isothiocyanatobenzyl)diethylenetriaminepentaacetic acid","1-(4-isothiocyanatobenzyl)diethylenetriaminepentaacetic acid","C054343",2,0,0,0,0,0,0]
["1-(4-methoxyphenyl)pyridinium","1-(4-methoxyphenyl)pyridinium","C026560",0,0,1,0,6,0,0]
["1-(4-methylpent-2-enyl)-2-(4-phenylbut-2-enyl)disulfane","1-(4-methylpent-2-enyl)-2-(4-phenylbut-2-enyl)disulfane","C553806",0,0,0,0,2,0,0]
["1-(4-methylpiperazin-1-yl)-3-(5-nitrofuran-2-yl)prop-2-en-1-one","1-(4-methylpiperazin-1-yl)-3-(5-nitrofuran-2-yl)prop-2-en-1-one","C000603673",0,0,0,0,2,0,0]
["1-(4-morpholinophenyl)-3-(3-fluorophenyl)propenone","1-(4-morpholinophenyl)-3-(3-fluorophenyl)propenone","C574513",0,0,0,0,2,0,0]
["1-(4-morpholinophenyl)-3-(4-fluorophenyl)propenone","1-(4-morpholinophenyl)-3-(4-fluorophenyl)propenone","C574514",0,0,0,0,2,0,0]
["1-(4-nitrophenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone","1-(4-nitrophenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone","C512077",0,0,0,0,2,0,0]
["1-(4-nitrophenyl)-2,5-di(2-thienyl)-1 H-pyrrole","1-(4-nitrophenyl)-2,5-di(2-thienyl)-1 H-pyrrole","C545172",2,0,0,0,0,0,0]
["1-(4-nitrophenyl)piperazine","1-(4-nitrophenyl)piperazine","C000595696",2,0,0,0,0,0,0]
["1-(4-nitrophenylsulfonyl)-N-(1-oxo-3-phenylpropan-2-yl)pyrrolidine-2-carboxamide","1-(4-nitrophenylsulfonyl)-N-(1-oxo-3-phenylpropan-2-yl)pyrrolidine-2-carboxamide","C513859",0,0,2,0,0,0,0]
["1-(4-toluenesulfonyl)cytosine","1-(4-toluenesulfonyl)cytosine","C509984",0,0,2,0,2,0,0]
["1-(4-trifluoromethoxyphenyl)-3-(4-(5-trifluoromethyl-2,5-dihydropyrazol-1-yl)phenyl)urea","1-(4-trifluoromethoxyphenyl)-3-(4-(5-trifluoromethyl-2,5-dihydropyrazol-1-yl)phenyl)urea","C577854",0,0,0,0,2,0,0]
["1-(5-((2,4-difluorophenyl)thio)-4-nitrothiophen-2-yl)ethanone","1-(5-((2,4-difluorophenyl)thio)-4-nitrothiophen-2-yl)ethanone","C570895",0,0,4,0,2,0,0]
["1-(5-(2-(3,5-dimethoxyphenyl)vinyl)-2-methoxyphenyl)-3-(2-morpholin-4-ylethyl)urea","1-(5-(2-(3,5-dimethoxyphenyl)vinyl)-2-methoxyphenyl)-3-(2-morpholin-4-ylethyl)urea","C539258",0,0,2,0,0,0,0]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C1604,B1604)","v":"1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine"},"1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine","C552956",14,1,0,0,0,0,0]
["1-(5-(3-((1-(4-fluorobenzyl)-1H-1,2,3-triazol-4-yl)methoxy)-4-methoxyphenyl)-3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)ethanone","1-(5-(3-((1-(4-fluorobenzyl)-1H-1,2,3-triazol-4-yl)methoxy)-4-methoxyphenyl)-3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)ethanone","C000615606",0,0,2,0,2,0,0]
["1-(5-(4-bromophenoxy)pentyl)-3-(4-pyridyl)-2-imidazolidinone","1-(5-(4-bromophenoxy)pentyl)-3-(4-pyridyl)-2-imidazolidinone","C492441",0,0,0,0,0,1,0]
["1-(5,5,5-trichloro-2-methoxy-4-oxopenten-2-yl)-4-trichloromethylpyrimidin-2(1H)-one","1-(5,5,5-trichloro-2-methoxy-4-oxopenten-2-yl)-4-trichloromethylpyrimidin-2(1H)-one","C000597458",0,0,2,0,2,0,0]
["1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl (E)-2-(4-(3-oxo-3-(3-(trifluoromethoxy)phenyl)prop-1-en-1-yl)phenoxy)acetate","1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl (E)-2-(4-(3-oxo-3-(3-(trifluoromethoxy)phenyl)prop-1-en-1-yl)phenoxy)acetate","C000620830",0,0,2,0,4,0,0]
["1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-enyl-3-(3-(trifluoromethyl)phenyl)acrylate","1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-enyl-3-(3-(trifluoromethyl)phenyl)acrylate","C586338",0,0,0,0,1,0,0]
["1-(5-bromo-2-pyridylazo)-2-naphthol-6-sulfonic acid","1-(5-bromo-2-pyridylazo)-2-naphthol-6-sulfonic acid","C433167",2,0,0,0,0,0,0]
["1-(5-carboxypentyl)-4-(2-(N-ethyl-carbazole-3-yl)vinyl)pyridinium bromide","1-(5-carboxypentyl)-4-(2-(N-ethyl-carbazole-3-yl)vinyl)pyridinium bromide","C000613210",2,0,0,0,0,0,0]
["1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea","1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea","C508388",0,0,0,0,0,1,0]
["1-(5-chloro-2-methyl-phenyl)-3-(4-(5-trifluoromethyl-pyrazol-1-yl)-phenyl)thiourea","1-(5-chloro-2-methyl-phenyl)-3-(4-(5-trifluoromethyl-pyrazol-1-yl)-phenyl)thiourea","C575050",0,0,0,0,2,0,0]
["1-(5-chloro-6-(3-methyl-4-(6-(trifluoromethyl)-4-(3,4,5-trifluorophenyl)-1H-benzo(d)imidazol-2-yl)piperazin-1-yl)pyridin-3-yl)ethane-1,2-diol","1-(5-chloro-6-(3-methyl-4-(6-(trifluoromethyl)-4-(3,4,5-trifluorophenyl)-1H-benzo(d)imidazol-2-yl)piperazin-1-yl)pyridin-3-yl)ethane-1,2-diol","C512086",2,0,0,0,0,0,0]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307",4,1,73,10,96,0,0]
["1-(5-isoquinolinylsulfonyl)-3-methylpiperazine","1-(5-isoquinolinylsulfonyl)-3-methylpiperazine","C080501",0,0,0,0,2,0,0]
["1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione","1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione","C060229",0,0,3,0,4,0,0]
["1-(6-(3,5-dichloro-4-hydroxyphenyl)-4-((4-((dimethylamino)methyl)cyclohexyl)amino)-1,5-naphthyridin-3-yl)ethanone","1-(6-(3,5-dichloro-4-hydroxyphenyl)-4-((4-((dimethylamino)methyl)cyclohexyl)amino)-1,5-naphthyridin-3-yl)ethanone","C585656",0,0,5,0,3,0,0]
["1-(9'-(o-carboxyphenyl)-6'-amino-2'-chloro-3'-xanthanone)-4,10-(diethyl)-7-(2-pyridylmethyl)-1,4,7,10-tetraazacyclododecane","1-(9'-(o-carboxyphenyl)-6'-amino-2'-chloro-3'-xanthanone)-4,10-(diethyl)-7-(2-pyridylmethyl)-1,4,7,10-tetraazacyclododecane","C473809",2,0,0,0,0,0,0]
["1-(9-fluorenyl)ethyl chloroformate","1-(9-fluorenyl)ethyl chloroformate","C052812",2,0,0,0,0,0,0]
["1-(9-fluorenyl)methyl chloroformate","1-(9-fluorenyl)methyl chloroformate","C054007",8,0,0,0,0,0,0]
["1-(9-hydroperoxy-10,12-octadecadienoyl)glycerol","1-(9-hydroperoxy-10,12-octadecadienoyl)glycerol","C426010",2,0,0,0,0,0,0]
["1-(acetyloxy)-3,5,6,6a,7,8,9,10-octahydro-10-hydroxy-7,8-dimethyl-7-(3-methylpenta-2,4-dien-1-yl)naphtho(1,8a-c)furan-3,5-diyl dibutanoate","1-(acetyloxy)-3,5,6,6a,7,8,9,10-octahydro-10-hydroxy-7,8-dimethyl-7-(3-methylpenta-2,4-dien-1-yl)naphtho(1,8a-c)furan-3,5-diyl dibutanoate","C548433",0,0,4,0,4,0,0]
["1-(benzofuran-2-yl(phenyl)methyl)-3-(2-(4-methoxyphenyl)-2-oxoethyl)-1H-benzo(d)imidazol-3-ium","1-(benzofuran-2-yl(phenyl)methyl)-3-(2-(4-methoxyphenyl)-2-oxoethyl)-1H-benzo(d)imidazol-3-ium","C583775",0,0,2,0,0,0,0]
["1-(benzofuran-2-yl(phenyl)methyl)-3-(2-(naphthalen-2-yl)-2-oxoethyl)-1H-benzo(d)imidazol-3-ium","1-(benzofuran-2-yl(phenyl)methyl)-3-(2-(naphthalen-2-yl)-2-oxoethyl)-1H-benzo(d)imidazol-3-ium","C583774",0,0,2,0,0,0,0]
["1-(benzofuran-2-yl)-2-propylaminopentane","1-(benzofuran-2-yl)-2-propylaminopentane","C404200",0,0,0,0,2,0,0]
["1-(carboxymethylthio)tetradecane","1-(carboxymethylthio)tetradecane","C062078",0,0,6,0,9,0,0]
["1-(chrysen-6-yl)-3-(4-nitrophenyl)thiourea","1-(chrysen-6-yl)-3-(4-nitrophenyl)thiourea","C000624346",0,0,2,0,2,0,0]
["1-(di-(2-pyridyl)methylene)-5-salicylidenethiocarbonohydrazide","1-(di-(2-pyridyl)methylene)-5-salicylidenethiocarbonohydrazide","C066715",2,0,0,0,0,0,0]
["1-(ferrocenemethyl)-1,4,7,10-tetraazacyclododecane","1-(ferrocenemethyl)-1,4,7,10-tetraazacyclododecane","C520109",2,0,0,0,0,0,0]
["1-(hydroxymethyl)-6,7,8-trihydroxyindolizidine","1-(hydroxymethyl)-6,7,8-trihydroxyindolizidine","C524717",0,0,2,0,0,0,0]
["1-(methylimino-N-oxy)-6-(2-morpholinoethoxy)-3-phenyl-1H-indene-2-carboxylic acid ethyl ester","1-(methylimino-N-oxy)-6-(2-morpholinoethoxy)-3-phenyl-1H-indene-2-carboxylic acid ethyl ester","C513115",0,0,2,0,6,0,0]
["1-(N-(2-hydroxyethyl)acetamido)-2-hydroxylaminoimidazole","1-(N-(2-hydroxyethyl)acetamido)-2-hydroxylaminoimidazole","C049945",2,0,0,0,0,0,0]
["1-(N-methyl-4,4'-bipyridinium)-1-(2-hydroxy-5-nitrophenyl)methane","1-(N-methyl-4,4'-bipyridinium)-1-(2-hydroxy-5-nitrophenyl)methane","C066054",2,0,0,0,0,0,0]
["1-(p-fluorphenacyl)-2-methyl-4-nitroimidazole","1-(p-fluorphenacyl)-2-methyl-4-nitroimidazole","C500177",0,0,2,0,0,0,0]
["1-(p-methoxyphenacyl)-2-methyl-4-nitroimidazole","1-(p-methoxyphenacyl)-2-methyl-4-nitroimidazole","C500178",0,0,2,0,0,0,0]
["1-(p-methylphenacyl)-2-methyl-4-nitro imidazole","1-(p-methylphenacyl)-2-methyl-4-nitro imidazole","C500176",0,0,2,0,0,0,0]
["1-(propoxymethyl)maleimide","1-(propoxymethyl)maleimide","C557741",0,0,2,0,6,0,0]
["1-(tert-butylamino)-3-(5-tert-butylaminomethyl-2-methoxyphenoxy)propan-2-ol","1-(tert-butylamino)-3-(5-tert-butylaminomethyl-2-methoxyphenoxy)propan-2-ol","C519077",0,1,0,0,0,0,0]
["1-(tetrahydro-4-hydroxy-5-(hydroxymethyl)furan-2-yl)pyrimidine-2,4(1H,3H)-dione","1-(tetrahydro-4-hydroxy-5-(hydroxymethyl)furan-2-yl)pyrimidine-2,4(1H,3H)-dione","C539903",0,0,2,0,0,0,0]
["1,(N2)-ethenoguanine","1,(N2)-ethenoguanine","C085534",0,0,0,0,0,2,0]
["1,1'-((((5-(trifluoromethyl)pyrimidine-2,4-diyl)bis(azanediyl))bis(3-methoxy-4,1-phenylene))bis(piperazine-4,1-diyl))bis(ethan-1-one)","1,1'-((((5-(trifluoromethyl)pyrimidine-2,4-diyl)bis(azanediyl))bis(3-methoxy-4,1-phenylene))bis(piperazine-4,1-diyl))bis(ethan-1-one)","C000597555",0,0,2,0,0,0,0]
["1,1'-((1,1'-biphenyl)-4,4'-diyl)bis(3-(piperidin-1-yl)propan-1-one)dihydrochloride","1,1'-((1,1'-biphenyl)-4,4'-diyl)bis(3-(piperidin-1-yl)propan-1-one)dihydrochloride","C000614891",0,0,0,0,2,0,0]
["1,1'-((4,4,7,7-tetramethyl)-4,7-diazaundecamethylene)bis-4-(3-methyl-2,3-dihydro(benzo-1,3-oxazole)-2-methylidene)quinolinium","1,1'-((4,4,7,7-tetramethyl)-4,7-diazaundecamethylene)bis-4-(3-methyl-2,3-dihydro(benzo-1,3-oxazole)-2-methylidene)quinolinium","C075296",2,0,0,0,0,0,0]
["1,1'-((propane-1,3-diyl)dioxy)bis(7-methoxy-2-methylidene-1,2,3,10,11,11a-hexahydro-5H-pyrrolo(2,1-c)(1,4)benzodiazepin-5,11-dione)","1,1'-((propane-1,3-diyl)dioxy)bis(7-methoxy-2-methylidene-1,2,3,10,11,11a-hexahydro-5H-pyrrolo(2,1-c)(1,4)benzodiazepin-5,11-dione)","C423343",0,0,0,0,2,0,0]
["1,1'-(1,3-phenylene)bis(3-(3,5-dimethylphenyl)thiourea)","1,1'-(1,3-phenylene)bis(3-(3,5-dimethylphenyl)thiourea)","C000595180",0,0,0,0,2,0,0]
["1,1'-(4,4,7,7-tetramethyl-4,7-diazaundecamethylene)bis-4-(3-methyl-2,3-dihydro(benzo-1,3-thiazole)-2-methylidene)quinolinium","1,1'-(4,4,7,7-tetramethyl-4,7-diazaundecamethylene)bis-4-(3-methyl-2,3-dihydro(benzo-1,3-thiazole)-2-methylidene)quinolinium","C075295",2,0,0,0,0,0,0]
["1,1'-(biphenyl-4,4'-diyl)-bis(3-(dimethylamino)propan-1-one)","1,1'-(biphenyl-4,4'-diyl)-bis(3-(dimethylamino)propan-1-one)","C000595502",0,0,0,0,2,0,0]
["1,1',1'',1'''-(ethylenedinitrilo)tetra-2-propanol","1,1',1'',1'''-(ethylenedinitrilo)tetra-2-propanol","C010629",4,0,0,0,0,0,0]
["1,1,1',1'-tetramethyl (60)fullerenodipyrrolidinium","1,1,1',1'-tetramethyl (60)fullerenodipyrrolidinium","C000593228",0,0,0,0,2,0,0]
["1,1,1,2-tetrachloroethane","1,1,1,2-tetrachloroethane","C031336",2,0,0,0,0,0,0]
["1,1,1,2-tetrafluoro-2-chloroethane","1,1,1,2-tetrafluoro-2-chloroethane","C072959",0,1,0,0,0,0,0]
["1,1,1,3,3-pentachloroacetone","1,1,1,3,3-pentachloroacetone","C054043",2,0,0,0,0,0,0]
["1,1,1,3,3-pentafluoropropane","1,1,1,3,3-pentafluoropropane","C403631",0,1,0,0,0,0,0]
["1,1,1-trichloroethane","1,1,1-trichloroethane","C024566",8,4,0,0,0,0,0]
["1,1,1-trifluoro-2-chloroethane","1,1,1-trifluoro-2-chloroethane","C016800",2,0,0,0,0,0,0]
["1,1,1-trifluoro-4-phenylbutan-2-one","1,1,1-trifluoro-4-phenylbutan-2-one","C059358",0,0,0,0,0,2,0]
["1,1,1-trifluoro-6-(naphthalen-2-yl)hexan-2-one","1,1,1-trifluoro-6-(naphthalen-2-yl)hexan-2-one","C587596",0,0,0,0,2,0,0]
["1,1,2,2-tetrachloroethane","1,1,2,2-tetrachloroethane","C015530",8,0,0,0,0,0,0]
["1,1',2,2'-tetraoleoylcardiolipin","1,1',2,2'-tetraoleoylcardiolipin","C519576",2,0,0,0,0,0,0]
["1,1,2-trichloro-3,3,3-trifluoro-1-propene","1,1,2-trichloro-3,3,3-trifluoro-1-propene","C060270",0,1,0,0,0,0,0]
["1,1',3,3,3',3'-hexamethylindotricarbocyanine","1,1',3,3,3',3'-hexamethylindotricarbocyanine","C053313",2,0,0,0,2,0,0]
["1,1,3,3-tetramethylguanidine","1,1,3,3-tetramethylguanidine","C477069",2,0,0,0,0,0,0]
["1,1,3,3-tetramethylurea","1,1,3,3-tetramethylurea","C004168",0,2,0,0,0,0,0]
["1,1,3-tris(3-indolyl)cyclohexane","1,1,3-tris(3-indolyl)cyclohexane","C531174",0,0,2,0,2,0,0]
["1,1,4,4-butanetetracarboxylic acid","1,1,4,4-butanetetracarboxylic acid","C065777",2,0,0,0,0,0,0]
["1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-N5-(2-phenylpropyl)-N5'-(2-phenylpropyl)-2,2'-binaphthyl-5,5'-dicarboxamide","1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-N5-(2-phenylpropyl)-N5'-(2-phenylpropyl)-2,2'-binaphthyl-5,5'-dicarboxamide","C550162",0,0,2,0,11,0,0]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C1668,B1668)","v":"1,10-phenanthroline"},"1,10-phenanthroline","C025205",28,4,25,0,35,2,0]
["1,10-phenanthroline-2,9-dicarboxylic acid","1,10-phenanthroline-2,9-dicarboxylic acid","C519844",2,0,0,0,0,0,0]
["1,10-phenanthroline-5,6-dione","1,10-phenanthroline-5,6-dione","C037153",4,0,4,0,0,0,0]
["1,10-phenanthroline-vanadyl complex","1,10-phenanthroline-vanadyl complex","C091442",2,0,0,0,0,0,0]
["1,12-benzoperylene","1,12-benzoperylene","C006718",2,0,0,0,0,0,0]
["1,12-bis(4-methyl-5-(2-hydroxyethyl)thiazol-3-ium-3-yl)dodecane","1,12-bis(4-methyl-5-(2-hydroxyethyl)thiazol-3-ium-3-yl)dodecane","C499114",2,0,0,0,0,0,0]
["1,12-diamino-3,6,9-triazadodecane","1,12-diamino-3,6,9-triazadodecane","C502960",0,0,4,0,0,0,0]
["1,12-diaziridinyl-4,9-diazadodecane","1,12-diaziridinyl-4,9-diazadodecane","C097784",0,0,0,0,2,0,0]
["1,12-dimethylspermine","1,12-dimethylspermine","C073195",0,0,2,0,2,0,0]
["1,12-dodecamethylenediamine","1,12-dodecamethylenediamine","C016417",2,3,0,0,2,0,0]
["1,13-bis(8-quinolyl)-1,4,7,10,13-pentaoxatridecane","1,13-bis(8-quinolyl)-1,4,7,10,13-pentaoxatridecane","C000593036",2,0,0,0,0,0,0]
["1,14-bis(2,3-dihydroxybenzoyl)-5,10-bis(1-hydroxy-2-pyridon-6-oyl)-1,5,10,14-tetraazatetradecane","1,14-bis(2,3-dihydroxybenzoyl)-5,10-bis(1-hydroxy-2-pyridon-6-oyl)-1,5,10,14-tetraazatetradecane","C080800",2,0,0,0,0,0,0]
["1,15-bis(ethylamino)-4,8,12-triazapentadecane","1,15-bis(ethylamino)-4,8,12-triazapentadecane","C094172",2,0,0,0,0,0,0]
["1,15-bis(N5-(3,3-(diphenyl)propyl)-N1-biguanido)-4,12-diazapentadecane","1,15-bis(N5-(3,3-(diphenyl)propyl)-N1-biguanido)-4,12-diazapentadecane","C000595073",0,0,2,0,0,0,0]
["1,1'-beta-D-glucopyranosyl-3,3'-bis(5-bromoindolyl)-octyl methane","1,1'-beta-D-glucopyranosyl-3,3'-bis(5-bromoindolyl)-octyl methane","C000598856",0,0,2,1,0,0,0]
["1,1'-binaphthyl","1,1'-binaphthyl","C412330",2,0,0,0,0,0,0]
["1,1'-binaphthyl-2,2'-diamine","1,1'-binaphthyl-2,2'-diamine","C500338",4,0,0,0,0,0,0]
["1,1'-binaphthyl-2,2'-diyl hydrogen phosphate","1,1'-binaphthyl-2,2'-diyl hydrogen phosphate","C107195",2,0,0,0,0,0,0]
["1,1-bis(3'-(5-methoxyindolyl))-1-(p-t-butylphenyl)indolesmethane","1,1-bis(3'-(5-methoxyindolyl))-1-(p-t-butylphenyl)indolesmethane","C500672",0,0,0,0,2,0,0]
["1,1-bis(3'-indolyl)-1-(4-biphenyl)methane","1,1-bis(3'-indolyl)-1-(4-biphenyl)methane","C505817",0,1,12,0,6,0,0]
["1,1-bis(3'-indolyl)-1-(4-chlorophenyl)methane","1,1-bis(3'-indolyl)-1-(4-chlorophenyl)methane","C534880",0,0,0,0,2,0,0]
["1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane","1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane","C552530",0,0,4,0,4,0,0]
["1,1-bis(3'-indolyl)-1-(4-t-butylphenyl)methane","1,1-bis(3'-indolyl)-1-(4-t-butylphenyl)methane","C505816",0,1,14,0,13,0,0]
["1,1-bis(3'-indolyl)-1-(4-trifluoromethylphenyl)methane","1,1-bis(3'-indolyl)-1-(4-trifluoromethylphenyl)methane","C492909",0,0,4,0,5,0,0]
["1,1-bis(3'-indolyl)-1-(p-anisyl)methane","1,1-bis(3'-indolyl)-1-(p-anisyl)methane","C545255",0,0,0,0,1,0,0]
["1,1-bis(3'-indolyl)methane","1,1-bis(3'-indolyl)methane","C512018",2,1,6,0,3,0,0]
["1,1-bis(4-hydroxyphenyl)-2-phenylbut-1-ene","1,1-bis(4-hydroxyphenyl)-2-phenylbut-1-ene","C052383",0,0,2,0,2,0,0]
["1,1-bis(4-hydroxyphenyl)cyclohexane","1,1-bis(4-hydroxyphenyl)cyclohexane","C517113",2,0,0,0,0,0,0]
["1,1'-bis-(4-sulfobutyl)indotricarbocyanine-5,5'-dicarboxylic acid diglucamide","1,1'-bis-(4-sulfobutyl)indotricarbocyanine-5,5'-dicarboxylic acid diglucamide","C430879",0,0,0,1,0,0,0]
["1,1-diamino-2,2-dinitroethene","1,1-diamino-2,2-dinitroethene","C533965",2,0,0,0,0,0,0]
["1,1-dichloro-2-(4-methoxyphenyl)-3-phenylcyclopropane","1,1-dichloro-2-(4-methoxyphenyl)-3-phenylcyclopropane","C531316",0,0,2,0,2,0,0]
["1,1-dichloro-2,3-diphenyl-2-(4-methoxyphenyl)cyclopropane","1,1-dichloro-2,3-diphenyl-2-(4-methoxyphenyl)cyclopropane","C075421",0,0,0,0,2,0,0]
["1,1-dichloro-4-ethyl-5-(4-nitrophenyl)hexan-2-one","1,1-dichloro-4-ethyl-5-(4-nitrophenyl)hexan-2-one","C561927",0,0,0,0,0,1,0]
["1,1-dichloroacetone","1,1-dichloroacetone","C051717",0,1,0,0,0,0,0]
["1,1-dichloroethane","1,1-dichloroethane","C501196",0,2,0,0,0,0,0]
["1,1-dichloropropene","1,1-dichloropropene","C500392",0,0,0,0,1,2,0]
["1,1-dicyano-2-(4,5-dimethoxy-2-nitrophenyl)ethene","1,1-dicyano-2-(4,5-dimethoxy-2-nitrophenyl)ethene","C417196",4,0,0,0,0,0,0]
["1,1-diethyl-2-hydroxy-2-nitrosohydrazine","1,1-diethyl-2-hydroxy-2-nitrosohydrazine","C084012",0,1,0,0,2,0,0]
["1,1-difluoro-1-trimethylsilanyl methylphosphonic acid","1,1-difluoro-1-trimethylsilanyl methylphosphonic acid","C522995",2,0,0,0,0,0,0]
["1,1-difluoro-3-hexadecanamido-2-(5-hydroxypentyl)-4-phenylbutanephosphonic acid","1,1-difluoro-3-hexadecanamido-2-(5-hydroxypentyl)-4-phenylbutanephosphonic acid","C473787",0,0,0,0,1,0,0]
["1,1-difluoroethylene","1,1-difluoroethylene","C007384",0,0,2,0,0,0,0]
["1,1-dimethyl-2-(2-(quinolin-4-yl)vinyl)-1H-benzo(e)indole","1,1-dimethyl-2-(2-(quinolin-4-yl)vinyl)-1H-benzo(e)indole","C000601531",2,0,1,0,0,0,0]
["1,1-dimethyl-4-acetylpiperazinium","1,1-dimethyl-4-acetylpiperazinium","C080419",0,0,1,0,0,0,0]
["1,1-dimethyl-5-(1-hydroxypropyl)-4,6,7-trimethylindan","1,1-dimethyl-5-(1-hydroxypropyl)-4,6,7-trimethylindan","C107655",2,0,0,0,0,0,0]
["1,1-dimethylbutyl-1-deoxy-Delta(9)-THC","1,1-dimethylbutyl-1-deoxy-Delta(9)-THC","C432747",0,0,7,3,11,0,0]
["1,1'-dimethylferrocene","1,1'-dimethylferrocene","C050099",2,0,0,0,0,0,0]
["1',1'-dimethylheptyl-delta(8)-tetrahydrocannabinol-11-oic acid","1',1'-dimethylheptyl-delta(8)-tetrahydrocannabinol-11-oic acid","C113759",0,1,0,0,0,0,0]
["1,1-dimethylurea","1,1-dimethylurea","C018275",2,0,0,0,0,1,0]
["1,1-diphenyl-2-picrylhydrazyl","1,1-diphenyl-2-picrylhydrazyl","C004931",36,0,8,0,4,0,0]
["1,1-diphenylethene","1,1-diphenylethene","C587461",2,0,0,0,0,0,0]
["1,1'-disulfobutyl-3,3,3',3'-tetramethylindotricarbocyanine","1,1'-disulfobutyl-3,3,3',3'-tetramethylindotricarbocyanine","C479728",2,0,0,0,0,0,0]
["1,1-ethanediol","1,1-ethanediol","C041868",2,0,0,0,0,0,0]
["1,1'-oxalyldiimidazole","1,1'-oxalyldiimidazole","C554599",2,0,0,0,0,0,0]
["1,2(4)-topaminequinone","1,2(4)-topaminequinone","C083552",2,0,0,0,0,0,0]
["1,2-(palmitoyl-NBD-aminocaproyl)phosphatidylethanolamine","1,2-(palmitoyl-NBD-aminocaproyl)phosphatidylethanolamine","C052267",2,0,0,0,0,0,0]
["1,2,2,4,5,5,-hexamethyl-3-imidazolidine oxide","1,2,2,4,5,5,-hexamethyl-3-imidazolidine oxide","C079221",4,0,0,0,0,0,0]
["1,2,3,4,6,7,8-heptachlorodibenzodioxin","1,2,3,4,6,7,8-heptachlorodibenzodioxin","C046839",0,0,0,0,2,0,0]
["1,2,3,4,6,7-hexachlorinated naphthalene","1,2,3,4,6,7-hexachlorinated naphthalene","C412791",0,1,0,0,0,0,0]
["1,2,3,4,6-penta-O-galloylglucopyranoside","1,2,3,4,6-penta-O-galloylglucopyranoside","C000615595",0,0,0,0,2,0,0]
["1,2,3,4-tetrahydro-1-(phenylmethyl)isoquinoline","1,2,3,4-tetrahydro-1-(phenylmethyl)isoquinoline","C084924",0,0,0,0,5,0,0]
["1,2,3,4-tetrahydro-1-phenylisoquinoline","1,2,3,4-tetrahydro-1-phenylisoquinoline","C096775",0,0,0,0,2,0,0]
["1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid","1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid","C054910",0,0,2,0,2,0,0]
["1,2,3,4-tetrahydroisoquinoline","1,2,3,4-tetrahydroisoquinoline","C014843",2,0,12,0,9,0,0]
["1,2,3,4-tetrahydroisoquinoline carboxylic acid","1,2,3,4-tetrahydroisoquinoline carboxylic acid","C031270",2,0,0,0,0,0,0]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C1732,B1732)","v":"1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid"},"1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid","C078986",4,0,0,0,0,0,0]
["1,2,3,4-tetrahydroquinoline","1,2,3,4-tetrahydroquinoline","C542964",4,0,10,0,4,0,0]
["1,2,3,5,6,7-hexachloronaphthalene","1,2,3,5,6,7-hexachloronaphthalene","C575652",0,1,0,0,0,0,0]
["1,2,3,5,6,7-hexahydroquinoxaline","1,2,3,5,6,7-hexahydroquinoxaline","C539014",0,0,0,0,0,1,0]
["1,2,3,6-tetragalloylglucose","1,2,3,6-tetragalloylglucose","C060475",2,0,0,0,0,0,0]
["1,2,3,7,8-pentachlorodibenzo-p-dioxin","1,2,3,7,8-pentachlorodibenzo-p-dioxin","C051452",0,0,2,0,1,0,0]
["1,2,3,9-tetrahydro-4H-carbazol-4-one","1,2,3,9-tetrahydro-4H-carbazol-4-one","C513019",2,0,0,0,0,0,0]
["1,2,3-trichloropropane","1,2,3-trichloropropane","C009536",2,1,2,0,0,2,0]
["1,2,4,5-benzenetetraamine","1,2,4,5-benzenetetraamine","C539551",0,0,4,0,4,0,0]
["1,2,4,5-tetrabromobenzene","1,2,4,5-tetrabromobenzene","C110818",0,1,0,0,0,0,0]
["1,2,4-butanetriol","1,2,4-butanetriol","C000610906",2,0,0,0,0,0,0]
["1,2,4-triazine","1,2,4-triazine","C093444",0,0,4,0,9,0,0]
["1,2,4-triazole","1,2,4-triazole","C045575",8,0,26,0,10,0,0]
["1,2,4-triazole(1,5a)pyrimidine","1,2,4-triazole(1,5a)pyrimidine","C419143",0,0,2,0,2,0,0]
["1,2,4-triazole-3-carboxamide","1,2,4-triazole-3-carboxamide","C017957",0,0,2,0,0,0,0]
["1,2,4-tribromobenzene","1,2,4-tribromobenzene","C026924",0,1,0,0,0,0,0]
["1,2,4-trichlorobenzene","1,2,4-trichlorobenzene","C009947",0,0,0,0,0,1,0]
["1,2,4-trihydroxyanthraquinone Be","1,2,4-trihydroxyanthraquinone Be","C116389",2,0,0,0,0,0,0]
["1,2,4-trinitrobenzene","1,2,4-trinitrobenzene","C043308",2,0,0,0,0,0,0]
["1,2,4-trioxane","1,2,4-trioxane","C503429",4,0,4,0,4,0,0]
["1,2,5,6-dibenzanthracene","1,2,5,6-dibenzanthracene","C026486",2,0,0,0,0,0,0]
["1,2,5,8-tetrahydroxy anthraquinone","1,2,5,8-tetrahydroxy anthraquinone","C543211",2,0,3,0,4,0,0]
["1,2,5-oxadiazole 2-oxide","1,2,5-oxadiazole 2-oxide","C528141",0,0,10,0,0,0,0]
["1,2,5-selenadiazolo-(3,4-d)pyrimidine-5,7-(4H,6H)-dione","1,2,5-selenadiazolo-(3,4-d)pyrimidine-5,7-(4H,6H)-dione","C529179",0,0,0,0,2,0,0]
["1,2,7,8-tetrachlorodibenzo-p-dioxin","1,2,7,8-tetrachlorodibenzo-p-dioxin","C445379",0,2,0,0,0,0,0]
["1,2,9,10-tetrachlorodecane","1,2,9,10-tetrachlorodecane","C467419",2,0,0,0,0,0,0]
["1,2,9,9a-tetrahydrocyclopropa(1,2-c)benz(1,2-e)indol-4-one","1,2,9,9a-tetrahydrocyclopropa(1,2-c)benz(1,2-e)indol-4-one","C506823",4,0,2,0,0,0,0]
["1,24-dihydroxyvitamin D2","1,24-dihydroxyvitamin D2","C063087",0,0,2,0,0,0,0]
["1,25-dihydroxy-16,23-diene vitamin D3","1,25-dihydroxy-16,23-diene vitamin D3","C116777",0,0,0,0,2,0,0]
["1,25-dihydroxy-16-ene-vitamin D3","1,25-dihydroxy-16-ene-vitamin D3","C087630",0,0,0,0,2,0,0]
["1,25-dihydroxy-19-norprevitamin D3","1,25-dihydroxy-19-norprevitamin D3","C083611",0,0,2,0,0,0,0]
["1,25-dihydroxy-19-norvitamin D3","1,25-dihydroxy-19-norvitamin D3","C083610",0,0,0,0,2,0,0]
["1,25-dihydroxy-20S-21(3-hydroxy-3-methyl-butyl)-23-yne-26,27-hexafluoro-vitamin D3","1,25-dihydroxy-20S-21(3-hydroxy-3-methyl-butyl)-23-yne-26,27-hexafluoro-vitamin D3","C514501",0,0,2,0,0,0,0]
["1,25-dihydroxy-21-(3-hydroxy-3-methyl-4,4,4-tributyl)-23-yne-26,27-hexafluorocholecalciferol","1,25-dihydroxy-21-(3-hydroxy-3-methyl-4,4,4-tributyl)-23-yne-26,27-hexafluorocholecalciferol","C552206",0,0,9,0,2,0,0]
["1,25-dihydroxy-21-(3-hydroxy-3-methylbutyl)vitamin D(3)","1,25-dihydroxy-21-(3-hydroxy-3-methylbutyl)vitamin D(3)","C411462",10,0,10,1,1,0,0]
["1,25-dihydroxy-23-thiavitamin D3","1,25-dihydroxy-23-thiavitamin D3","C074474",0,0,0,0,2,0,0]
["1,25-dihydroxy-26-(hydroxymethyl)-26-methylvitamin D3","1,25-dihydroxy-26-(hydroxymethyl)-26-methylvitamin D3","C560303",0,0,2,0,0,0,0]
["1,25-dihydroxy-26-(hydroxymethyl)vitamin D3","1,25-dihydroxy-26-(hydroxymethyl)vitamin D3","C560304",0,0,2,0,0,0,0]
["1,25-dihydroxyergocalciferol","1,25-dihydroxyergocalciferol","C003564",0,0,7,1,3,0,0]
["1,25-dihydroxyvitamin D","1,25-dihydroxyvitamin D","C097949",0,2,31,0,21,0,0]
["1,25-dihydroxyvitamin D3-3-bromoacetate","1,25-dihydroxyvitamin D3-3-bromoacetate","C104313",0,0,10,0,12,0,0]
["1,2-benzenedithiol","1,2-benzenedithiol","C102217",2,0,0,0,0,0,0]
["1,2-benzisothiazoline-3-one","1,2-benzisothiazoline-3-one","C015699",4,0,2,0,2,0,0]
["1,2-benzodithiol-3-one-1,1-dioxide","1,2-benzodithiol-3-one-1,1-dioxide","C414667",2,0,0,0,0,0,0]
["1,2-bis(10(2',4'-hexadienoyloxy)decanoyl)-sn-glycero-3-phosphocholine","1,2-bis(10(2',4'-hexadienoyloxy)decanoyl)-sn-glycero-3-phosphocholine","C077390",2,0,0,0,0,0,0]
["1,2-bis(11-aminoundecanoyl)-3-glucopyranosylglycerol","1,2-bis(11-aminoundecanoyl)-3-glucopyranosylglycerol","C478012",2,0,0,0,0,0,0]
["1,2'-bis(2-(1,3-benzothiazol-2-yl)phenoxy)-2-ethoxyethane","1,2'-bis(2-(1,3-benzothiazol-2-yl)phenoxy)-2-ethoxyethane","C000594738",2,0,0,0,0,0,0]
["1,2-bis(2-amino-5,6-difluorophenoxy)ethane-N,N,N',N'-tetraacetic acid","1,2-bis(2-amino-5,6-difluorophenoxy)ethane-N,N,N',N'-tetraacetic acid","C087511",2,0,0,0,0,0,0]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379",29,7,2,0,59,1,0]
["1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","C025603",31,1,2,0,37,1,0]
["1,2-bis(2-pyridyl)ethylene","1,2-bis(2-pyridyl)ethylene","C530364",0,0,2,0,0,0,0]
["1,2-bis(3,5-dioxopiperazin-1-yl)ethane","1,2-bis(3,5-dioxopiperazin-1-yl)ethane","C000283",0,0,0,0,2,0,0]
["1,2-bis(isothiazol-5-yl)disulfane","1,2-bis(isothiazol-5-yl)disulfane","C579148",0,0,2,0,2,0,0]
["1,2-bis(methylsulfonyl)-1--(2-chloroethyl)-2-((1-(4-nitrophenyl)ethoxy)carbonyl)hydrazine","1,2-bis(methylsulfonyl)-1--(2-chloroethyl)-2-((1-(4-nitrophenyl)ethoxy)carbonyl)hydrazine","C118156",2,0,0,0,0,0,0]
["1,2-bis(octadeca-2,4-dienoyl)-glycero-3-phosphocholine","1,2-bis(octadeca-2,4-dienoyl)-glycero-3-phosphocholine","C102749",2,0,0,0,0,0,0]
["1,2-bis-manephosphotidylcholine","1,2-bis-manephosphotidylcholine","C045294",2,0,0,0,0,0,0]
["1,2-cyclohexanediamine","1,2-cyclohexanediamine","C030435",4,0,6,0,7,0,0]
["1,2-cyclohexanediol","1,2-cyclohexanediol","C064619",2,2,0,0,0,0,0]
["1,2-cyclohexanedione","1,2-cyclohexanedione","C018031",4,0,0,0,0,0,0]
["1,2-dehydro-N-acetyldopamine","1,2-dehydro-N-acetyldopamine","C053357",6,0,0,0,0,0,0]
["1,2-di(quinazolin-4-yl)diselane","1,2-di(quinazolin-4-yl)diselane","C000613607",0,0,2,0,2,0,0]
["1,2-diacetoxy-6-methoxy-3,3,14-trimethyl-1,2,3,14-tetrahydro-7H-benzo(b)chromeno(6,5-g)(1,8)naphthyridin-7-one","1,2-diacetoxy-6-methoxy-3,3,14-trimethyl-1,2,3,14-tetrahydro-7H-benzo(b)chromeno(6,5-g)(1,8)naphthyridin-7-one","C000595867",0,0,2,0,0,0,0]
["1,2-diacetylbenzene","1,2-diacetylbenzene","C048792",0,2,0,0,4,0,0]
["1,2-diacylglycerol","1,2-diacylglycerol","C011439",19,2,3,0,6,0,0]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C1796,B1796)","v":"1,2-diamino-4,5-methylenedioxybenzene"},"1,2-diamino-4,5-methylenedioxybenzene","C058886",2,0,0,0,0,0,0]
["1,2-diaminoanthraquinone","1,2-diaminoanthraquinone","C118201",0,0,2,0,2,0,0]
["1,2-diaminobenzene","1,2-diaminobenzene","C034193",24,0,0,0,0,0,0]
["1,2-diaminocyclohexaneplatinum II citrate","1,2-diaminocyclohexaneplatinum II citrate","C044245",0,0,0,0,2,0,0]
["1,2-diaminocyclohexyl platinum sulfate","1,2-diaminocyclohexyl platinum sulfate","C024236",2,0,0,0,2,0,0]
["1,2-dianilinoethane","1,2-dianilinoethane","C007305",2,0,0,0,0,0,0]
["1,2-diarachidonoyl-glycero-3-phosphoethanolamine","1,2-diarachidonoyl-glycero-3-phosphoethanolamine","C044820",0,1,0,0,2,0,0]
["1,2-dibromo-2,4-dicyanobutane","1,2-dibromo-2,4-dicyanobutane","C039411",0,0,2,0,0,0,0]
["1,2-dibromobenzene","1,2-dibromobenzene","C102879",0,2,0,0,0,0,0]
["1,2-dichloro-4-nitrobenzene","1,2-dichloro-4-nitrobenzene","C028328",2,0,0,0,0,0,0]
["1,2-dichloroethylene","1,2-dichloroethylene","C035384",2,0,0,0,0,1,0]
["1,2-didecanoylphosphatidylcholine","1,2-didecanoylphosphatidylcholine","C015132",0,6,0,0,0,0,0]
["1,2-didodecanoyl-glycero-3-phosphocholine","1,2-didodecanoyl-glycero-3-phosphocholine","C054349",2,0,0,0,0,0,0]
["1,2-dielaidoylphosphatidylethanolamine","1,2-dielaidoylphosphatidylethanolamine","C020888",28,1,0,0,3,0,0]
["1,2-diethylbenzene","1,2-diethylbenzene","C064750",0,2,0,0,0,0,0]
["1,2-diformylhydrazine","1,2-diformylhydrazine","C017224",2,0,0,0,0,0,0]
["1,2-dihexadecyl-3-O-octadecenoyl-sn-glycerol","1,2-dihexadecyl-3-O-octadecenoyl-sn-glycerol","C038662",2,0,0,0,0,0,0]
["1,2-dihexadecyl-sn-glycero-3-phosphocholine","1,2-dihexadecyl-sn-glycero-3-phosphocholine","C052298",6,0,0,0,0,0,0]
["1,2-dihexanoylphosphatidylethanolamine","1,2-dihexanoylphosphatidylethanolamine","C048072",4,0,0,0,0,0,0]
["1,2-dihexanoyl-sn-glycero-3-phosphorylcholine","1,2-dihexanoyl-sn-glycero-3-phosphorylcholine","C092445",2,0,0,0,0,0,0]
["1,2-dihydro-1,8,10-trihydroxy-2-(2-hydroxypropan-2-yl)-9-(3-methylbut-2-enyl)furo(3,2-a)xanthen-11-one","1,2-dihydro-1,8,10-trihydroxy-2-(2-hydroxypropan-2-yl)-9-(3-methylbut-2-enyl)furo(3,2-a)xanthen-11-one","C530094",0,0,2,0,0,0,0]
["1,2-dihydro-5-(1H-indol-2-yl)-1,2,4-triazole-3-thione","1,2-dihydro-5-(1H-indol-2-yl)-1,2,4-triazole-3-thione","C586652",0,0,2,0,0,0,0]
["1,2-dihydro-alpha-santonin","1,2-dihydro-alpha-santonin","C032735",2,0,0,0,0,0,0]
["1',2'-dihydrorotenone","1',2'-dihydrorotenone","C044985",0,0,0,0,2,0,0]
["1,2-dihydroxy-1,2-dihydronaphthalene","1,2-dihydroxy-1,2-dihydronaphthalene","C042334",4,0,0,0,0,0,0]
["1,2-dihydroxy-4'-chlorobiphenyl","1,2-dihydroxy-4'-chlorobiphenyl","C074625",2,0,0,0,0,0,0]
["1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt","1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt","D014013",8,1,6,0,11,0,0]
["1,2-dihydroxy-epoxy-1,2,3,4-tetrahydro-5-methylchrysene","1,2-dihydroxy-epoxy-1,2,3,4-tetrahydro-5-methylchrysene","C037783",0,0,0,0,1,3,0]
["1,2-dihydroxynaphthalene","1,2-dihydroxynaphthalene","C050642",0,0,0,0,2,0,0]
["1,2-dilauroylphosphatidylcholine","1,2-dilauroylphosphatidylcholine","C015153",12,0,0,0,0,0,0]
["1,2-dilauroylphosphatidylethanolamine","1,2-dilauroylphosphatidylethanolamine","C007445",4,0,0,0,0,0,0]
["1,2-dilinoleoyl-3-phosphatidylethanolamine","1,2-dilinoleoyl-3-phosphatidylethanolamine","C038191",0,0,0,0,2,0,0]
["1,2-dimethoxyethane","1,2-dimethoxyethane","C024683",2,0,0,0,0,0,0]
["1,2-Dimethylhydrazine","1,2-Dimethylhydrazine","D019813",16,1,43,4,55,1,0]
["1,2-dimethylimidazole","1,2-dimethylimidazole","C032654",2,0,0,0,0,0,0]
["1,2-dimethylindole-3-sulfonyl chloride","1,2-dimethylindole-3-sulfonyl chloride","C543052",2,0,0,0,0,0,0]
["1,2-dimyristoylphosphatidylethanolamine","1,2-dimyristoylphosphatidylethanolamine","C018525",6,0,0,0,0,0,0]
["1,2-dimyristoyl-sn-glycero-3-phosphatidylethanol","1,2-dimyristoyl-sn-glycero-3-phosphatidylethanol","C104364",2,0,0,0,0,0,0]
["1,2-dioctanoylglycerol","1,2-dioctanoylglycerol","C044295",13,0,0,0,0,0,0]
["1,2-dioctanoylthiophosphatidylcholine","1,2-dioctanoylthiophosphatidylcholine","C053953",2,0,0,0,0,0,0]
["1,2-dioleoyl-3-succinylglycerol","1,2-dioleoyl-3-succinylglycerol","C088169",2,0,0,0,0,0,0]
["1,2-dioleoyl-glycero-3-phosphatidyl ethanolamine","1,2-dioleoyl-glycero-3-phosphatidyl ethanolamine","C410262",30,0,0,0,3,0,0]
["1,2-dioleoyloxy-3-(trimethylammonium)propane","1,2-dioleoyloxy-3-(trimethylammonium)propane","C070046",20,2,5,0,5,0,0]
["1,2-dioleoylphosphatidylserine","1,2-dioleoylphosphatidylserine","C042511",18,0,3,0,5,0,0]
["1,2-dioleoyl-sn-glycero-3-phosphoglycerol","1,2-dioleoyl-sn-glycero-3-phosphoglycerol","C051388",8,0,0,0,4,0,0]
["1,2-dioxetane","1,2-dioxetane","C079142",2,0,0,0,0,0,0]
["1,2-dipalmitoyl glycero-3-thiophosphate","1,2-dipalmitoyl glycero-3-thiophosphate","C050849",2,0,0,0,0,0,0]
["1,2-dipalmitoyl-3-phosphatidylethanolamine","1,2-dipalmitoyl-3-phosphatidylethanolamine","C007510",16,0,4,0,0,0,0]
["1,2-dipalmitoyl-3-succinylglycerol","1,2-dipalmitoyl-3-succinylglycerol","C088171",2,0,0,0,0,0,0]
["1,2-dipalmitoyloxypropanethiophospho-1-inositol","1,2-dipalmitoyloxypropanethiophospho-1-inositol","C106414",0,0,0,0,0,1,0]
["1,2-Dipalmitoylphosphatidylcholine","1,2-Dipalmitoylphosphatidylcholine","D015060",96,2,4,0,4,0,0]
["1,2-dipalmitoylphosphatidylglycerol","1,2-dipalmitoylphosphatidylglycerol","C030345",24,0,0,0,0,0,0]
["1,2-dipalmitoyl-sn-glycero-3-phosphatidylethanol","1,2-dipalmitoyl-sn-glycero-3-phosphatidylethanol","C104363",2,0,0,0,0,0,0]
["1,2-diphenylhydrazine","1,2-diphenylhydrazine","C032041",2,0,0,0,0,0,0]
["1,2-diphytanoylphosphatidylcholine","1,2-diphytanoylphosphatidylcholine","C021016",12,0,0,0,0,0,0]
["1,2-distearoyllecithin","1,2-distearoyllecithin","C010942",10,0,4,1,0,0,0]
["1,2-distearoylphosphatidylethanolamine","1,2-distearoylphosphatidylethanolamine","C038089",8,0,6,0,0,0,0]
["1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-methoxy-poly(ethylene glycol 2000)","1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-methoxy-poly(ethylene glycol 2000)","C519184",4,0,5,0,3,0,0]
["1,2-dithienylcyclopentene","1,2-dithienylcyclopentene","C517933",2,0,0,0,0,0,0]
["1,2-dithiol-3-thione","1,2-dithiol-3-thione","C049325",0,0,2,0,5,2,0]
["1,2-dithiolane","1,2-dithiolane","C448825",0,0,2,0,0,0,0]
["1,2-dithiolane-4-carboxylic acid","1,2-dithiolane-4-carboxylic acid","C010035",0,0,0,0,1,0,0]
["1,2-epoxy-3,4-dihydroxy-1,2,3,4-tetrahydrobenzo(c)phenanthrene","1,2-epoxy-3,4-dihydroxy-1,2,3,4-tetrahydrobenzo(c)phenanthrene","C090203",0,0,0,0,0,2,0]
["1,2-ethanedithiol","1,2-ethanedithiol","C031854",2,0,2,0,0,0,0]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C1860,B1860)","v":"1,2-heptanoylphosphatidylcholine"},"1,2-heptanoylphosphatidylcholine","C038470",2,0,0,0,0,0,0]
["1,2-hexanoylphosphatidylcholine","1,2-hexanoylphosphatidylcholine","C032166",6,0,0,0,0,0,0]
["1,2-indanedione","1,2-indanedione","C413384",2,0,0,0,0,0,0]
["1,2-isopropylidene-6-chloro-deoxyglucofuranose","1,2-isopropylidene-6-chloro-deoxyglucofuranose","C055776",2,0,0,0,0,0,0]
["1,2-ketimino-7-amino-8-hydroxynaphthalene-3,6-disulfonic acid","1,2-ketimino-7-amino-8-hydroxynaphthalene-3,6-disulfonic acid","C488308",2,0,0,0,0,0,0]
["1,2-linoleoylphosphatidylcholine","1,2-linoleoylphosphatidylcholine","C002448",6,0,0,0,4,0,0]
["1,2-naphthalenedicarboxylic anhydride","1,2-naphthalenedicarboxylic anhydride","C120468",0,0,2,0,2,0,0]
["1,2-naphthoquinone","1,2-naphthoquinone","C040756",2,0,4,0,2,1,0]
["1,2-naphthoquinone-1-methide","1,2-naphthoquinone-1-methide","C545849",2,0,0,0,0,0,0]
["1,2-naphthoquinone-4-sulfonate","1,2-naphthoquinone-4-sulfonate","C011942",14,0,0,0,0,0,0]
["1,2-O-isopropylidene glycerol","1,2-O-isopropylidene glycerol","C507843",2,0,0,0,0,0,0]
["1,2-oleoylphosphatidylcholine","1,2-oleoylphosphatidylcholine","C017251",58,0,0,0,0,0,0]
["1,3-((4-(2,4-diamino-5-methylphenyl)diazenylphenyl)hydrazinylidene)-6-oxocyclohexa-1,4-diene-1-carboxylic acid","1,3-((4-(2,4-diamino-5-methylphenyl)diazenylphenyl)hydrazinylidene)-6-oxocyclohexa-1,4-diene-1-carboxylic acid","C553279",0,0,0,0,2,0,0]
["1,3,4,5-tetramethyl-2-((2-oxopropyl)thio)imidazolium","1,3,4,5-tetramethyl-2-((2-oxopropyl)thio)imidazolium","C088946",2,0,0,0,0,0,0]
["1,3,4,6-tetrachloro-3 alpha,6 alpha-diphenylglycoluril","1,3,4,6-tetrachloro-3 alpha,6 alpha-diphenylglycoluril","C012385",4,0,0,0,0,0,0]
["1,3,4-oxadiazole","1,3,4-oxadiazole","C583463",0,0,31,0,11,0,0]
["1,3,4-thiadiazole","1,3,4-thiadiazole","C058949",6,0,30,0,4,0,0]
["1,3,4-thiadiazole hydroxamic acid","1,3,4-thiadiazole hydroxamic acid","C576646",0,0,2,0,0,0,0]
["1,3,4-tri-O-galloyl-6-O-caffeoyl-beta-D-glucopyranose","1,3,4-tri-O-galloyl-6-O-caffeoyl-beta-D-glucopyranose","C580888",0,0,1,0,2,0,0]
["1,3,5,7-cyclooctatetraene","1,3,5,7-cyclooctatetraene","C534209",2,0,0,0,0,0,0]
["1,3,5,7-tetramethyl-8-(4'-aminophenyl)-4,4-difluoro-4-bora-3a,4a-diaza-s-indacence","1,3,5,7-tetramethyl-8-(4'-aminophenyl)-4,4-difluoro-4-bora-3a,4a-diaza-s-indacence","C492643",2,0,0,0,0,0,0]
["1,3,5,7-tetramethyl-8-phenyl-(2-maleimide)-difluoroboradiaza-s-indacene","1,3,5,7-tetramethyl-8-phenyl-(2-maleimide)-difluoroboradiaza-s-indacene","C534661",2,0,0,0,0,0,0]
["1,3,5,8-tetrahydroxy-2,4-bis(3-methyl-2-butenyl)xanthone","1,3,5,8-tetrahydroxy-2,4-bis(3-methyl-2-butenyl)xanthone","C000605798",0,0,4,0,6,0,0]
["1,3,5-triamino-1,3,5-trideoxy-inositol","1,3,5-triamino-1,3,5-trideoxy-inositol","C116452",4,0,0,0,0,0,0]
["1,3,5-triamino-2,4,6-trimethoxycyclohexane","1,3,5-triamino-2,4,6-trimethoxycyclohexane","C421445",2,0,0,0,0,0,0]
["1,3,5-triaminocyclohexane","1,3,5-triaminocyclohexane","C421444",4,0,0,0,0,0,0]
["1,3,5-triaza-7-phosphaadamantane","1,3,5-triaza-7-phosphaadamantane","C501763",2,0,14,0,2,0,0]
["1,3,5-triazaspiro(5.5)undeca-1,3-diene","1,3,5-triazaspiro(5.5)undeca-1,3-diene","C548621",0,0,2,0,0,0,0]
["1,3,5-triazine-2,4,6-triamine hexaacetic acid","1,3,5-triazine-2,4,6-triamine hexaacetic acid","C000607934",2,0,0,0,0,0,0]
["1,3,5-trideoxy-1,3,5-tris(dimethylamino)-cis-inositol","1,3,5-trideoxy-1,3,5-tris(dimethylamino)-cis-inositol","C438143",4,0,0,0,0,0,0]
["1,3,5-trihydroxy-13,13-dimethyl-2H-pyran(7,6-b)xanthone","1,3,5-trihydroxy-13,13-dimethyl-2H-pyran(7,6-b)xanthone","C576555",0,0,0,0,2,0,0]
["1,3,5-trihydroxy-6-methoxy-7-(3-methylbut-2-enyl)xanthone","1,3,5-trihydroxy-6-methoxy-7-(3-methylbut-2-enyl)xanthone","C534859",0,0,0,0,1,0,0]
["1,3,5-trimethoxy-2-(9-anthracenyl)methylamino-4,6-diaminocyclohexane","1,3,5-trimethoxy-2-(9-anthracenyl)methylamino-4,6-diaminocyclohexane","C448020",2,0,0,0,0,0,0]
["1,3,5-tris((2,3-dihydroxybenzylidene)aminomethyl)cyclohexane","1,3,5-tris((2,3-dihydroxybenzylidene)aminomethyl)cyclohexane","C538816",2,0,0,0,0,0,0]
["1,3,5-tris((oxiran-2-yl)methyl)-1,3,5-triazinane-2,4,6-trione","1,3,5-tris((oxiran-2-yl)methyl)-1,3,5-triazinane-2,4,6-trione","C000592913",0,0,0,0,2,0,0]
["1,3,5-tris(4-hydroxyphenyl)-4-propyl-1H-pyrazole","1,3,5-tris(4-hydroxyphenyl)-4-propyl-1H-pyrazole","C419153",0,0,11,0,4,0,0]
["1,3,6,7-tetrahydroxyxanthone","1,3,6,7-tetrahydroxyxanthone","C575656",0,0,2,0,2,0,0]
["1,3,6,8-pyrene tetrasulfonate","1,3,6,8-pyrene tetrasulfonate","C041343",2,0,0,0,0,0,0]
["1,3,6,8-tetrahydroxynaphthalene","1,3,6,8-tetrahydroxynaphthalene","C121288",0,0,0,0,0,1,0]
["1,3,6-naphthalenetrisulfonate","1,3,6-naphthalenetrisulfonate","C114532",0,0,0,2,2,0,0]
["1,3,6-pyrenetrisulfonic acid trisodium salt","1,3,6-pyrenetrisulfonic acid trisodium salt","C569134",2,0,0,0,0,0,0]
["1,3,6-trihydroxy-2-methyl-9,10-anthraquinone-3-O-(6'-acetylglucoside)","1,3,6-trihydroxy-2-methyl-9,10-anthraquinone-3-O-(6'-acetylglucoside)","C069463",0,0,0,0,2,0,0]
["1,3,6-trisulfonylpyrene 8-isothiocyanate","1,3,6-trisulfonylpyrene 8-isothiocyanate","C034660",2,0,0,0,0,0,0]
["1,3,8-trihydroxy-6-methoxyanthraquinone","1,3,8-trihydroxy-6-methoxyanthraquinone","C460121",0,0,2,0,0,0,0]
["1,3a,6a-triazapentalene","1,3a,6a-triazapentalene","C568178",0,0,2,0,0,0,0]
["1,3-alternate 25,27-dipropoxy-26,28-bis-(3-propyloxy)-calix(4)arene","1,3-alternate 25,27-dipropoxy-26,28-bis-(3-propyloxy)-calix(4)arene","C498313",2,0,0,0,0,0,0]
["1,3-benzenediamidoethanethiol","1,3-benzenediamidoethanethiol","C473336",2,0,0,0,0,0,0]
["1,3-benzodioxole","1,3-benzodioxole","C040539",0,2,0,0,0,0,0]
["1,3-benzothiazol-2-yl(2-((2-(3-pyridinyl)ethyl)amino)-4-pyrimidinyl)acetonitrile","1,3-benzothiazol-2-yl(2-((2-(3-pyridinyl)ethyl)amino)-4-pyrimidinyl)acetonitrile","C489138",0,0,1,0,2,0,0]
["1,3-bis((3,4,5-trihydroxybenzoyl)oxy)naphthalene","1,3-bis((3,4,5-trihydroxybenzoyl)oxy)naphthalene","C572947",0,0,2,0,2,0,0]
["1,3-bis(1,1,3,3,5,5-hexaethoxy-1,3,5-trisilacyclohexyl)propane","1,3-bis(1,1,3,3,5,5-hexaethoxy-1,3,5-trisilacyclohexyl)propane","C512088",0,0,1,0,0,0,0]
["1,3-bis(2-(1,3-benzothiazol-2-yl)phenoxy)propane","1,3-bis(2-(1,3-benzothiazol-2-yl)phenoxy)propane","C000594737",2,0,0,0,0,0,0]
["1,3-bis(3,5-dichlorophenyl)urea","1,3-bis(3,5-dichlorophenyl)urea","C577482",0,0,2,0,4,0,0]
["1,3-bis(4-amidinophenoxy)-2-(4-amidinophenoxymethyl)ethylpropane","1,3-bis(4-amidinophenoxy)-2-(4-amidinophenoxymethyl)ethylpropane","C074442",4,0,0,0,0,0,0]
["1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole","1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole","C524478",0,0,0,0,6,0,0]
["1,3-bis(4-morpholino)-2-O-sulfopropane","1,3-bis(4-morpholino)-2-O-sulfopropane","C503727",2,0,0,0,0,0,0]
["1,3-bis(bis(pyridin-2-ylmethyl)amino)propan-2-ol","1,3-bis(bis(pyridin-2-ylmethyl)amino)propan-2-ol","C514153",6,0,0,0,0,0,0]
["1,3-bis(N,N,N-trimethylammonium)-2-propylacrylate dichloride","1,3-bis(N,N,N-trimethylammonium)-2-propylacrylate dichloride","C555758",2,0,0,0,0,0,0]
["1,3-bis(N,N,N-trimethylammonium)-2-propylmethacrylate dichloride","1,3-bis(N,N,N-trimethylammonium)-2-propylmethacrylate dichloride","C555757",2,0,0,0,0,0,0]
["1,3-bis(N,N-dimethylamino)-2-O-sulfopropane","1,3-bis(N,N-dimethylamino)-2-O-sulfopropane","C503728",2,0,0,0,0,0,0]
["1,3-bis(N,N-dipropylamino)-2-O-sulfopropane","1,3-bis(N,N-dipropylamino)-2-O-sulfopropane","C503729",2,0,0,0,0,0,0]
["1,3-bis(tris(hydroxymethyl)methylamino)propane","1,3-bis(tris(hydroxymethyl)methylamino)propane","C034249",6,0,0,0,0,0,0]
["1,3-butadiene","1,3-butadiene","C031763",8,2,2,0,5,20,0]
["1,3-butyl ethylene glycol disalicylate","1,3-butyl ethylene glycol disalicylate","C000601791",2,0,0,0,0,0,0]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C1924,B1924)","v":"1,3-butylene glycol"},"1,3-butylene glycol","C028491",4,0,0,0,0,0,0]
["1,3-capryloyl-2-arachidonoyl glycerol","1,3-capryloyl-2-arachidonoyl glycerol","C539983",0,0,0,0,2,0,0]
["1,3-cyclic glycerophosphate","1,3-cyclic glycerophosphate","C081854",2,0,0,0,0,0,0]
["1,3-cyclohexadiene","1,3-cyclohexadiene","C034005",0,0,2,0,0,0,0]
["1,3-di(1H-indol-3-yl)propan-2-one","1,3-di(1H-indol-3-yl)propan-2-one","C547592",2,0,0,0,0,0,0]
["1,3-di-(4-amidinophenoxy)-2,2-bis-(4-amidinophenoxymethyl)propane","1,3-di-(4-amidinophenoxy)-2,2-bis-(4-amidinophenoxymethyl)propane","C057885",2,0,0,0,0,0,0]
["1,3-diacetoxy-1-(4-nitrophenyl)-2-propylisothiocyanate","1,3-diacetoxy-1-(4-nitrophenyl)-2-propylisothiocyanate","C408386",2,0,0,0,0,0,0]
["1,3-diaza-2-oxophenothiazin-3-ylacetic acid","1,3-diaza-2-oxophenothiazin-3-ylacetic acid","C492077",2,0,0,0,0,0,0]
["1,3-dibromo-2-propanone","1,3-dibromo-2-propanone","C047048",2,0,0,0,0,0,0]
["1,3-dibromo-5,5-dimethylhydantoin","1,3-dibromo-5,5-dimethylhydantoin","C056578",2,0,0,0,0,0,0]
["1,3-dibromobenzene","1,3-dibromobenzene","C102880",0,2,0,0,0,0,0]
["1,3-dichloro-1-propene","1,3-dichloro-1-propene","C023891",10,6,2,0,0,0,0]
["1,3-dichloro-2-propanol","1,3-dichloro-2-propanol","C033489",4,2,0,0,8,0,0]
["1,3-dichloro-4,4,5,5-tetramethyl-2-imidazolidinone","1,3-dichloro-4,4,5,5-tetramethyl-2-imidazolidinone","C069218",2,0,0,0,0,0,0]
["1,3-dichloro-6-trifluoromethyl-9-phenanthryl-3-(n-butyl)aminopropanol","1,3-dichloro-6-trifluoromethyl-9-phenanthryl-3-(n-butyl)aminopropanol","C044961",4,0,0,0,0,0,0]
["1,3-dichloroacetone","1,3-dichloroacetone","C047675",2,1,0,0,0,0,0]
["1,3-dichlorobenzene","1,3-dichlorobenzene","C042146",2,0,0,0,0,0,0]
["1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one","1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one","C532657",0,0,2,0,2,0,0]
["1,3-dihydro-6-methoxy-1-methyl-3-((3,4,5-trimethoxyphenyl)methylene)-2H-indol-2-one","1,3-dihydro-6-methoxy-1-methyl-3-((3,4,5-trimethoxyphenyl)methylene)-2H-indol-2-one","C546021",0,0,2,0,0,0,0]
["1,3-dihydroxy-12H-benzo(b)xanthen-12-one","1,3-dihydroxy-12H-benzo(b)xanthen-12-one","C543282",0,0,2,0,0,0,0]
["1,3-dihydroxy-5-(tridec-4',7'-dienyl)benzene","1,3-dihydroxy-5-(tridec-4',7'-dienyl)benzene","C499259",0,0,2,0,2,0,0]
["1,3-dihydroxy-5,6-dimethoxy-2-methoxymethyl-9,10-anthraquinone","1,3-dihydroxy-5,6-dimethoxy-2-methoxymethyl-9,10-anthraquinone","C534270",0,0,2,0,0,0,0]
["1,3-dihydroxy-5,6-dimethoxy-7-(3-methylbut-2-enyl)xanthone","1,3-dihydroxy-5,6-dimethoxy-7-(3-methylbut-2-enyl)xanthone","C534858",0,0,0,0,1,0,0]
["1,3-dihydroxy-9,10-anthraquinone-2-carboxylic acid","1,3-dihydroxy-9,10-anthraquinone-2-carboxylic acid","C000609613",0,0,0,0,2,0,0]
["1,3-dimethyl-1,3-bis(4-fluorophenyl)-1,3-bis(3-(1-(4-butypiperazinyl))propyl)disiloxane","1,3-dimethyl-1,3-bis(4-fluorophenyl)-1,3-bis(3-(1-(4-butypiperazinyl))propyl)disiloxane","C523096",0,0,0,0,2,0,0]
["1,3-dimethyl-2-((2-oxopropyl)sulfanyl)-1H-imidazol-3-ium","1,3-dimethyl-2-((2-oxopropyl)sulfanyl)-1H-imidazol-3-ium","C000613701",0,0,0,0,2,0,0]
["1,3-dimethyl-2-((2-oxopropyl)thio)imidazolium","1,3-dimethyl-2-((2-oxopropyl)thio)imidazolium","C088947",2,0,0,0,0,0,0]
["1,3-dimethylthiourea","1,3-dimethylthiourea","C038983",2,5,0,0,13,2,0]
["1,3-dinitropyrene","1,3-dinitropyrene","C037413",0,0,0,0,2,1,0]
["1,3-di-O-feruloylquinic acid","1,3-di-O-feruloylquinic acid","C420868",2,0,0,0,0,0,0]
["1,3-dipalmitoyl-2-phosphatidylcholine","1,3-dipalmitoyl-2-phosphatidylcholine","C039559",4,0,0,0,0,0,0]
["1,3-diphenyl-3-(piperidin-1-yl)propan-1-one","1,3-diphenyl-3-(piperidin-1-yl)propan-1-one","C000611208",0,0,2,0,2,0,0]
["1,3-diphenyl-4-(4'-fluro)benzal-5-pyrazolone-4-ethyl thiosemicarbazone","1,3-diphenyl-4-(4'-fluro)benzal-5-pyrazolone-4-ethyl thiosemicarbazone","C504553",2,0,0,0,0,0,0]
["1,3-dipropyl-8-cyclopentylxanthine","1,3-dipropyl-8-cyclopentylxanthine","C051360",4,2,6,0,2,0,0]
["1,3-dipyridylazulene","1,3-dipyridylazulene","C518680",2,0,0,0,0,0,0]
["1,3-dithiane","1,3-dithiane","C012947",2,0,0,0,0,0,0]
["1,3-ditolylguanidine","1,3-ditolylguanidine","C050232",0,1,0,0,0,0,0]
["1,3-mannosylmannose","1,3-mannosylmannose","C108662",2,0,0,0,0,0,0]
["1,3-o-hydroxyphenyl-5-phenylformazan","1,3-o-hydroxyphenyl-5-phenylformazan","C512103",2,0,0,0,0,0,0]
["1,3-pentadiene","1,3-pentadiene","C011970",4,0,0,0,0,0,0]
["1,3-propane sultone","1,3-propane sultone","C003218",2,1,0,0,0,0,0]
["1,3-propanediol","1,3-propanediol","C041787",58,0,7,0,0,2,0]
["1,3-propanedithiol","1,3-propanedithiol","C508630",2,0,0,0,0,0,0]
["1,3-xylan","1,3-xylan","C065917",2,0,2,0,2,0,0]
["1,4-(4-4'-Bis-((4-(dimethylamine)pyridinium-1-yl) methyl)diphenyl)butane dibromide","1,4-(4-4'-Bis-((4-(dimethylamine)pyridinium-1-yl) methyl)diphenyl)butane dibromide","C507944",0,0,6,0,5,0,0]
["1,4,13-trihydroxy-eudesm-11(12)-ene","1,4,13-trihydroxy-eudesm-11(12)-ene","C511332",0,0,2,0,0,0,0]
["1,4,5,6,7,9-hexahydroxy-2-methoxy-7-methyl-5,6,8,8a,9,10a-hexahydro-7,9-epoxyanthracen-10-one","1,4,5,6,7,9-hexahydroxy-2-methoxy-7-methyl-5,6,8,8a,9,10a-hexahydro-7,9-epoxyanthracen-10-one","C540512",0,0,2,0,0,0,0]
["1,4,5,8-naphthalene tetracarboxylic acid 4,5-anhydride","1,4,5,8-naphthalene tetracarboxylic acid 4,5-anhydride","C075326",2,0,0,0,0,0,0]
["1,4,5,8-naphthalenetetracarboxylic diimide","1,4,5,8-naphthalenetetracarboxylic diimide","C429685",0,0,0,0,2,0,0]
["1,4,6,7,9-pentahydroxy-2-methoxy-7-methyl-5,6,8,8a,9,10a-hexahydro-7,9-epoxyanthracen-10-one","1,4,6,7,9-pentahydroxy-2-methoxy-7-methyl-5,6,8,8a,9,10a-hexahydro-7,9-epoxyanthracen-10-one","C540513",0,0,2,0,0,0,0]
["1,4,6-trihydroxy-2-methoxy-7-methyl-5,6,8,8a,9,10a-hexahydro-7,9-epoxyanthracen-10-one","1,4,6-trihydroxy-2-methoxy-7-methyl-5,6,8,8a,9,10a-hexahydro-7,9-epoxyanthracen-10-one","C540511",0,0,2,0,0,0,0]
["1,4,7,10,13,16,21,24-octaazabicyclo(8.8.8)hexacosane","1,4,7,10,13,16,21,24-octaazabicyclo(8.8.8)hexacosane","C525617",0,0,2,0,0,0,0]
["1,4,7,10,13,16-hexathia-18-crown-2,3,11,12-tetraone","1,4,7,10,13,16-hexathia-18-crown-2,3,11,12-tetraone","C441452",2,0,0,0,0,0,0]
["1,4,7,10-tetra(carboxyethyl)-1,4,7,10-tetraazacyclododecane","1,4,7,10-tetra(carboxyethyl)-1,4,7,10-tetraazacyclododecane","C436943",2,0,0,0,0,0,0]
["1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid","1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid","C071349",36,2,4,2,4,0,0]
["1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylenephosphonic acid)","1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylenephosphonic acid)","C082084",2,0,0,0,0,0,0]
["1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid","1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid","C520644",8,0,2,0,0,0,0]
["1,4,7,10-tetraazacyclododecane-1,4,7-trisacetic acid-10-maleimidoethylacetamide-europium","1,4,7,10-tetraazacyclododecane-1,4,7-trisacetic acid-10-maleimidoethylacetamide-europium","C549509",2,0,0,0,0,0,0]
["1,4,7,10-tetraazacyclododecane-1,7-diacetic acid","1,4,7,10-tetraazacyclododecane-1,7-diacetic acid","C561329",2,0,0,0,0,0,0]
["1,4,7,10-tetrakis(2,2'-bipyridyl-5-ylmethyl-bis(2,2'-bipyridine)ruthenium(II))-1,4,7,10-tetraazacyclododecane","1,4,7,10-tetrakis(2,2'-bipyridyl-5-ylmethyl-bis(2,2'-bipyridine)ruthenium(II))-1,4,7,10-tetraazacyclododecane","C453699",2,0,0,0,0,0,0]
["1,4,7,10-tetrakis(carbamoylmethyl)-1,4,7,10-tetraazacyclododecane","1,4,7,10-tetrakis(carbamoylmethyl)-1,4,7,10-tetraazacyclododecane","C522450",6,0,0,0,0,0,0]
["1,4,7-triazacyclononane","1,4,7-triazacyclononane","C075712",14,0,2,0,0,0,0]
["1,4,7-triazacyclononane-1-(methyl(2-carboxyethyl)phosphinic acid)-4,7-bis(methyl(2-hydroxymethyl)phosphinic acid)","1,4,7-triazacyclononane-1-(methyl(2-carboxyethyl)phosphinic acid)-4,7-bis(methyl(2-hydroxymethyl)phosphinic acid)","C576503",2,0,0,0,0,0,0]
["1,4,7-triazacyclononane-1,4,7-tris-(glutaric acid)","1,4,7-triazacyclononane-1,4,7-tris-(glutaric acid)","C581281",2,0,0,0,0,0,0]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C1988,B1988)","v":"1,4,7-triazacyclononane-1,4-diacetic acid-7-p-hydroxyphenylacetic acid"},"1,4,7-triazacyclononane-1,4-diacetic acid-7-p-hydroxyphenylacetic acid","C540064",2,0,0,0,0,0,0]
["1,4,7-triazacyclononane-1,4-diacetic acid-7-p-isothiocyanatophenylacetic acid","1,4,7-triazacyclononane-1,4-diacetic acid-7-p-isothiocyanatophenylacetic acid","C540062",2,0,0,0,0,0,0]
["1,4,7-triazacyclononane-1-acetic acid-4,7-di-p-isothiocyanatophenylacetic acid","1,4,7-triazacyclononane-1-acetic acid-4,7-di-p-isothiocyanatophenylacetic acid","C540063",2,0,0,0,0,0,0]
["1,4,7-triazacyclononane-N,N',N''-triacetic acid","1,4,7-triazacyclononane-N,N',N''-triacetic acid","C048993",8,0,2,2,2,0,0]
["1,4,7-triazacyclononane-N,N',N''-tris(methylenephosphonate monoethyl ester)","1,4,7-triazacyclononane-N,N',N''-tris(methylenephosphonate monoethyl ester)","C068116",2,0,0,0,0,0,0]
["1,4,7-tris(carbamoylmethyl)-1,4,7,10- tetraazacyclododecane","1,4,7-tris(carbamoylmethyl)-1,4,7,10- tetraazacyclododecane","C525828",2,0,0,0,0,0,0]
["1,4,7-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecane","1,4,7-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecane","C436944",2,0,0,0,0,0,0]
["1,4,8,12-tetraazacyclotetradecane osmium(III) chloride","1,4,8,12-tetraazacyclotetradecane osmium(III) chloride","C530492",2,0,0,0,0,0,0]
["1,4,-benzenedicarboxylic acid, 2-(10-(dimethylamino)-4-fluoro-3-oxo-3H-benzo(c)xanthen-7-yl)","1,4,-benzenedicarboxylic acid, 2-(10-(dimethylamino)-4-fluoro-3-oxo-3H-benzo(c)xanthen-7-yl)","C521638",2,0,0,0,0,0,0]
["1,4-androstadiene-3,17-dione","1,4-androstadiene-3,17-dione","C006573",4,0,0,0,2,1,0]
["1,4-anthraquinone","1,4-anthraquinone","C416442",0,0,2,0,0,0,0]
["1,4-benzodioxan","1,4-benzodioxan","C527681",0,0,6,0,2,0,0]
["1,4-benzoquinone guanylhydrazone thiosemicarbazone","1,4-benzoquinone guanylhydrazone thiosemicarbazone","C037931",2,0,0,0,0,0,0]
["1,4-bis(1-naphthyl)-2,3-dinitro-1,3-butadiene","1,4-bis(1-naphthyl)-2,3-dinitro-1,3-butadiene","C500384",0,0,4,0,2,0,0]
["1,4-diacetoxy-2,3-dicyanobenzene","1,4-diacetoxy-2,3-dicyanobenzene","C057660",4,0,0,0,0,0,0]
["1,4-dihydropyrimidine","1,4-dihydropyrimidine","C586280",0,0,6,0,0,0,0]
["1,4-hexadiene","1,4-hexadiene","C032726",2,0,0,0,0,0,0]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C2052,B2052)","v":"1,5,9,13,17,21,25,29-octaazacyclodotriacontane"},"1,5,9,13,17,21,25,29-octaazacyclodotriacontane","C522301",2,0,0,0,0,0,0]
["1,5-bis(2,3-dimethoxyphenyl)penta-1,4-dien-3-one","1,5-bis(2,3-dimethoxyphenyl)penta-1,4-dien-3-one","C560296",0,0,2,0,2,0,0]
["1,5-dihydro-7-(1-piperidinyl)-imidazo(2,1-b)quinazolin-2(3H)-one","1,5-dihydro-7-(1-piperidinyl)-imidazo(2,1-b)quinazolin-2(3H)-one","C049662",0,0,2,0,0,0,0]
["1,6-anhydro-3,4-dideoxyhex-3-enopyran-2-ulose","1,6-anhydro-3,4-dideoxyhex-3-enopyran-2-ulose","C512757",0,0,2,0,0,0,0]
["1,7,7-trimethylbicyclo(2.2.1)heptan-2-yl 3-(3,4-dihydroxyphenyl)-2-hydroxypropanoate","1,7,7-trimethylbicyclo(2.2.1)heptan-2-yl 3-(3,4-dihydroxyphenyl)-2-hydroxypropanoate","C554681",0,0,0,0,1,0,0]
["1,8-diazafluoren-one","1,8-diazafluoren-one","C406982",0,0,1,0,0,0,0]
["1,N(6)-ethenoadenine","1,N(6)-ethenoadenine","C004981",2,0,0,0,0,4,0]
["10-(octyloxy)decyl-2-(trimethylammonium)ethyl phosphate","10-(octyloxy)decyl-2-(trimethylammonium)ethyl phosphate","C552819",0,0,1,0,4,0,0]
["10,10'-dimethyl-9,9'-biacridinium bis(monomethyl terephthalate)","10,10'-dimethyl-9,9'-biacridinium bis(monomethyl terephthalate)","C000599298",0,0,0,0,1,0,0]
["10-antofine N-oxide","10-antofine N-oxide","C420907",0,0,0,0,2,0,0]
["10-hydroxy-11,12-cyclopropyleicosa-5,8,14-trienoic acid methyl ester","10-hydroxy-11,12-cyclopropyleicosa-5,8,14-trienoic acid methyl ester","C454100",0,0,0,0,2,0,0]
["10-methoxy-9-nitrocamptothecin","10-methoxy-9-nitrocamptothecin","C513484",2,0,8,0,3,0,0]
["11,13-dihydro-dehydroleucodine","11,13-dihydro-dehydroleucodine","C518543",0,0,2,0,2,0,0]
["11-hydroxy-5,8,12,14-eicosatetraenoic acid","11-hydroxy-5,8,12,14-eicosatetraenoic acid","C027356",0,0,0,2,0,0,0]
["11-nor-delta(9)-tetrahydrocannabinol-9-carboxylic acid","11-nor-delta(9)-tetrahydrocannabinol-9-carboxylic acid","C016780",14,0,0,0,0,0,0]
["12,20-dihydroxy-5,8,10,14-eicosatetraenoic acid","12,20-dihydroxy-5,8,10,14-eicosatetraenoic acid","C040735",2,0,0,0,0,0,0]
["12-deoxyphorbolphenylacetate-20-acetate","12-deoxyphorbolphenylacetate-20-acetate","C029705",0,0,0,0,2,0,0]
["12-oleanene-3,16,23,28-tetrol","12-oleanene-3,16,23,28-tetrol","C546448",0,0,2,0,0,0,0]
["13,14-dihydro-15-ketoprostaglandin E1","13,14-dihydro-15-ketoprostaglandin E1","C036808",2,0,0,0,0,0,0]
["1396-11 compound","1396-11 compound","C520470",0,0,2,0,4,0,0]
["13-hydroperoxylinoleic acid","13-hydroperoxylinoleic acid","C032890",0,0,0,0,1,0,0]
["14-deoxyandrographolide","14-deoxyandrographolide","C114791",0,0,0,0,4,0,0]
["14-fluororetinal","14-fluororetinal","C065196",2,0,0,0,0,0,0]
["15-cyclohexyl-omega-pentanor-7-thiaprostaglandin E1","15-cyclohexyl-omega-pentanor-7-thiaprostaglandin E1","C051203",2,0,0,0,0,0,0]
["15-hydroxyeicosanoic acid","15-hydroxyeicosanoic acid","C073049",0,0,0,0,2,0,0]
["16-(4-fluorophenoxy)lipoxin A4","16-(4-fluorophenoxy)lipoxin A4","C447621",0,0,2,2,2,0,0]
["16-hydroxypalmitic acid","16-hydroxypalmitic acid","C063407",0,0,0,0,1,0,0]
["17,18,19,20-tetranor-16-(3-biphenyl)-2,3,13,14-tetradehydroprostaglandin E1","17,18,19,20-tetranor-16-(3-biphenyl)-2,3,13,14-tetradehydroprostaglandin E1","C561620",0,0,2,0,0,0,0]
["17-octadecynoic acid","17-octadecynoic acid","C047008",0,0,0,1,0,0,0]
["19-hydroxy-1alpha,6-diacetoxy-6,7-seco-ent-kaur-16-en-15-one-7,20-olide","19-hydroxy-1alpha,6-diacetoxy-6,7-seco-ent-kaur-16-en-15-one-7,20-olide","C547088",0,0,0,0,2,0,0]
["1a alloantigen, human","1a alloantigen, human","C039231",0,0,2,2,1,0,0]
["1-allyl-3-(2-ethoxyethyl)trisulfide","1-allyl-3-(2-ethoxyethyl)trisulfide","C000607509",0,0,0,0,1,0,0]
["1alpha-hydroxymethyl-16-ene-24,24-difluoro-25-hydroxy-26,27-bis-homovitamin D3","1alpha-hydroxymethyl-16-ene-24,24-difluoro-25-hydroxy-26,27-bis-homovitamin D3","C580739",0,0,0,0,2,0,0]
["1-aminopyrene","1-aminopyrene","C004482",2,0,2,0,0,0,0]
["1-benzoyl-N-(4-nitrophenyl)-3-phenyl-6,7-dihydro-1H-pyrazolo(4,3-c)pyridine-5(4H)-carboxamide","1-benzoyl-N-(4-nitrophenyl)-3-phenyl-6,7-dihydro-1H-pyrazolo(4,3-c)pyridine-5(4H)-carboxamide","C000589300",0,0,2,0,0,0,0]
["1-beta-aminoethylferrocene","1-beta-aminoethylferrocene","C572365",0,0,2,0,0,0,0]
["1-butyl-3-methylimidazolium hexafluorophosphate","1-butyl-3-methylimidazolium hexafluorophosphate","C412621",25,0,2,0,0,0,0]
["1-cyclohexyluracil","1-cyclohexyluracil","C000538",2,0,0,0,0,0,0]
["1-deoxy-1-((N-(phosphonomethyl)-2-oxoethyl)amino)mannitol-6-phosphate","1-deoxy-1-((N-(phosphonomethyl)-2-oxoethyl)amino)mannitol-6-phosphate","C405337",2,0,0,0,0,0,0]
["1-ethyl-2-pyrrolidinylmethyl-alpha-phenylcyclopentylglycolate, 1-ethyl-3-piperidyl-alpha-phenylcyclopentylglycolate drug combination","1-ethyl-2-pyrrolidinylmethyl-alpha-phenylcyclopentylglycolate, 1-ethyl-3-piperidyl-alpha-phenylcyclopentylglycolate drug combination","C001621",2,0,0,0,0,0,0]
["1-fluoro-2-(3-pyridinyl)ethylidene-1,1-bisphosphonic acid","1-fluoro-2-(3-pyridinyl)ethylidene-1,1-bisphosphonic acid","C526809",0,0,1,0,0,0,0]
["1-hexanol","1-hexanol","C036260",4,2,0,0,0,0,0]
["1H-Indene-2-carboxylic acid, 1-(1,3-benzodioxol-5-yl)-3-(2- (carboxymethoxy)-4-methoxyphenyl)-2,3-dihydro-5-propoxy-, (1S,2R,3S)-","1H-Indene-2-carboxylic acid, 1-(1,3-benzodioxol-5-yl)-3-(2- (carboxymethoxy)-4-methoxyphenyl)-2,3-dihydro-5-propoxy-, (1S,2R,3S)-","C087551",2,0,0,0,4,0,0]
["1-hydroxy-1-phenyl-2-propanone","1-hydroxy-1-phenyl-2-propanone","C035293",8,0,0,0,0,0,0]
["1-hydroxyanthraquinone","1-hydroxyanthraquinone","C061208",0,0,0,0,0,1,0]
["1-kestose","1-kestose","C072433",2,0,2,0,0,0,0]
["1-methyl-1,4-dihydroindeno(1,2-c)pyrazole","1-methyl-1,4-dihydroindeno(1,2-c)pyrazole","C000619632",0,0,2,0,0,0,0]
["1-methyl-3-octylimidazolium bromide","1-methyl-3-octylimidazolium bromide","C534649",0,0,0,0,2,0,0]
["1-methylcytosine","1-methylcytosine","C031532",4,0,0,0,0,0,0]
["1-methylpiperazine","1-methylpiperazine","C048073",2,0,0,0,0,0,0]
["1-myristoyl-2-(12-((5-dimethylamino-1-naphthalenesulfonyl)amino)dodecanoyl)-sn-glycero-3-phosphocholine","1-myristoyl-2-(12-((5-dimethylamino-1-naphthalenesulfonyl)amino)dodecanoyl)-sn-glycero-3-phosphocholine","C496906",6,0,2,0,0,0,0]
["1-Naphthylisothiocyanate","1-Naphthylisothiocyanate","D015058",2,6,7,0,6,0,0]
["1-nitronaphthalene","1-nitronaphthalene","C016614",4,5,0,0,0,0,0]
["1-O-(beta-D-galactopyranosyl)-(2S,3S,4R,8Z)-2-((2'R)-2'-hydroxydocosanoilamino)-8(Z)-octadecene-1,3,4-triol","1-O-(beta-D-galactopyranosyl)-(2S,3S,4R,8Z)-2-((2'R)-2'-hydroxydocosanoilamino)-8(Z)-octadecene-1,3,4-triol","C550893",0,0,2,0,0,0,0]
["1-octyl-3-benzylimidazolium bromide","1-octyl-3-benzylimidazolium bromide","C000593650",2,0,0,0,0,0,0]
["1-O-hexadecyl-2-desoxy-2-aminoarachidonoylglycero-3-phosphocholine","1-O-hexadecyl-2-desoxy-2-aminoarachidonoylglycero-3-phosphocholine","C091046",0,0,0,0,1,0,0]
["1-oleoyl-2-((N-(7-(nitro)-2,1,3-benzoxadiazol-4-yl)amino)hexanoyl)glycero-3-phosphate","1-oleoyl-2-((N-(7-(nitro)-2,1,3-benzoxadiazol-4-yl)amino)hexanoyl)glycero-3-phosphate","C086969",2,0,0,0,0,0,0]
["1-palmitoyl-2-(5-oxovaleroyl)phosphatidylcholine","1-palmitoyl-2-(5-oxovaleroyl)phosphatidylcholine","C119546",0,0,0,0,1,0,0]
["1-palmitoyl-2-oleyl-sn-glycero-3-ethylphosphocholine","1-palmitoyl-2-oleyl-sn-glycero-3-ethylphosphocholine","C000613173",2,0,2,0,0,0,0]
["1-palmityl-2-acetylglycerol","1-palmityl-2-acetylglycerol","C055394",0,0,2,0,0,0,0]
["1-phenyl-2-palmitoylamino-3-morpholino-1-propanol","1-phenyl-2-palmitoylamino-3-morpholino-1-propanol","C095823",0,0,0,0,1,0,0]
["1-tetradecyl-3-methylimidazolium","1-tetradecyl-3-methylimidazolium","C521426",2,0,0,0,0,0,0]
["2-((1-(2-(2-(2-(1-(2-hydroxybenzylideneamino)ethyl)phenyl)diselanyl)phenyl)ethylimino)methyl)phenol","2-((1-(2-(2-(2-(1-(2-hydroxybenzylideneamino)ethyl)phenyl)diselanyl)phenyl)ethylimino)methyl)phenol","C539691",2,0,0,0,0,0,0]
["2-((2,6-dichlorophenyl)amino)benzeneacetic acid 4-(3H-1,2-dithiol-3-thione-5-yl)phenyl ester","2-((2,6-dichlorophenyl)amino)benzeneacetic acid 4-(3H-1,2-dithiol-3-thione-5-yl)phenyl ester","C520611",0,0,2,0,4,0,0]
["2-((4-(4-(acridin-9-ylamino)phenylthio)phenyl)(2-hydroxyethyl)amino)ethan-1-ol","2-((4-(4-(acridin-9-ylamino)phenylthio)phenyl)(2-hydroxyethyl)amino)ethan-1-ol","C530271",0,0,2,0,1,0,0]
["2-((4-methylphenyl)sulfonyl)-5-nitrofuran","2-((4-methylphenyl)sulfonyl)-5-nitrofuran","C000604167",0,0,2,0,0,0,0]
["2-((N-ethylcarbazole)-3-sulfonylethylenediamine)-1-N,N-2-(2-methypyridy)","2-((N-ethylcarbazole)-3-sulfonylethylenediamine)-1-N,N-2-(2-methypyridy)","C573849",2,0,0,0,0,0,0]
["2-(1H-indol-3-yl)-3-pentylamino-maleimide","2-(1H-indol-3-yl)-3-pentylamino-maleimide","C503757",0,2,0,0,2,0,0]
["2-(2-(2-(diethylamino)-2-oxoacetamido)propan-2-yl)-4-(4-fluorobenzylcarbamoyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-5-yl benzoate","2-(2-(2-(diethylamino)-2-oxoacetamido)propan-2-yl)-4-(4-fluorobenzylcarbamoyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-5-yl benzoate","C573637",0,0,2,0,0,0,0]
["2-(2',4'-diacetoxy-5'-carboxypentanoyl)octadecylcellobioside","2-(2',4'-diacetoxy-5'-carboxypentanoyl)octadecylcellobioside","C476096",2,0,0,0,0,0,0]
["2-(2-aminocyclohexylamino)-4-(m-tolylamino)pyrimidine-5-carboxamide","2-(2-aminocyclohexylamino)-4-(m-tolylamino)pyrimidine-5-carboxamide","C569036",0,0,2,0,2,0,0]
["2-(2-chlorostyryl)-3,5,6-trimethylpyrazine","2-(2-chlorostyryl)-3,5,6-trimethylpyrazine","C000613321",0,0,0,0,2,0,0]
["2-(2'-hydroxyphenyl)benzoxazole","2-(2'-hydroxyphenyl)benzoxazole","C433838",2,0,0,0,0,0,0]
["2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)acetamide","2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)acetamide","C096011",0,4,4,2,1,0,0]
["2-(3-((((2-chlorobenzyl)amino)carbonyl)amino)-2-thienyl)-5,6-dihydroxypyrimidine-4-carboxylic acid","2-(3-((((2-chlorobenzyl)amino)carbonyl)amino)-2-thienyl)-5,6-dihydroxypyrimidine-4-carboxylic acid","C509708",0,0,0,0,0,1,0]
["2-(3-(4-((2,6-dimethylmorpholino)methyl)styryl)-1H-indazol-6-yl)-5'-methoxyspiro(cyclopropane-1,3'-indolin)-2'-one","2-(3-(4-((2,6-dimethylmorpholino)methyl)styryl)-1H-indazol-6-yl)-5'-methoxyspiro(cyclopropane-1,3'-indolin)-2'-one","C000592365",0,0,3,0,0,0,0]
["2-(3,4-dimethoxybenzylidene)-5-(4-hydroxy-3-methoxybenzylidene)cyclopentanone","2-(3,4-dimethoxybenzylidene)-5-(4-hydroxy-3-methoxybenzylidene)cyclopentanone","C000614105",0,0,2,0,2,0,0]
["2-(3-chlorophenyloamino)-5-(2,4-dihydroxyphenyl)-1,3,4-thiadiazole","2-(3-chlorophenyloamino)-5-(2,4-dihydroxyphenyl)-1,3,4-thiadiazole","C570682",0,0,2,0,0,0,0]
["2-(3-maleimidopropanamido)-9-(((succinimido)oxycarbonyl)oxymethyl)-7-sulfofluorene","2-(3-maleimidopropanamido)-9-(((succinimido)oxycarbonyl)oxymethyl)-7-sulfofluorene","C492427",2,0,0,0,0,0,0]
["2-(4-(2-(4-(dimethylamino)phenyl)pyridin-4-yl)-5-(3-methoxy-5-methylphenyl)-1H-pyrazol-1-yl)acetonitrile","2-(4-(2-(4-(dimethylamino)phenyl)pyridin-4-yl)-5-(3-methoxy-5-methylphenyl)-1H-pyrazol-1-yl)acetonitrile","C579033",0,0,2,1,2,0,0]
["2-(4-(4-(benzyloxy)benzyl)piperazin-1-yl)-N'-(3,5-di-tert-butyl-2-hydroxybenzylidene)acetohydrazide","2-(4-(4-(benzyloxy)benzyl)piperazin-1-yl)-N'-(3,5-di-tert-butyl-2-hydroxybenzylidene)acetohydrazide","C000597017",0,0,2,0,4,0,0]
["2-(4-(dimethylamino)styryl)-1-methylpyridinium","2-(4-(dimethylamino)styryl)-1-methylpyridinium","C011786",6,0,0,0,0,0,0]
["2-(4-amino-3-chloro-5-trifluomethyl-phenyl)-2-tert-butylamino-ethanol chloride","2-(4-amino-3-chloro-5-trifluomethyl-phenyl)-2-tert-butylamino-ethanol chloride","C477926",0,0,2,0,0,0,0]
["2-(4-chlorophenoxy)-N-(4-(2-(4-chlorophenoxy)acetamido)cyclohexyl)acetamide","2-(4-chlorophenoxy)-N-(4-(2-(4-chlorophenoxy)acetamido)cyclohexyl)acetamide","C000599093",0,0,0,0,0,1,0]
["2-(4-hydroxyanilino)-4-(4-chlorophenyl)thiazole","2-(4-hydroxyanilino)-4-(4-chlorophenyl)thiazole","C530150",0,0,2,0,2,0,0]
["2-(4'-methylaminophenyl)benzothiazole","2-(4'-methylaminophenyl)benzothiazole","C473078",2,0,0,0,0,0,0]
["2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole","2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole","C408604",0,1,0,0,2,0,0]
["2-(5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-(2-hydroxypentan-3-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid","2-(5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-(2-hydroxypentan-3-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid","C575269",0,0,2,0,0,0,0]
["2-(6-(2-carboxyvinyl)-2,3-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)acrylic acid","2-(6-(2-carboxyvinyl)-2,3-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)acrylic acid","C539487",0,0,2,0,6,0,0]
["2-(6'-methyl-2'-benzothiazolylazo)chromotropic acid","2-(6'-methyl-2'-benzothiazolylazo)chromotropic acid","C515530",2,0,0,0,0,0,0]
["2-(benzylsulfinyl)ethyl pyridin-3-ylmethylcarbamodithioate","2-(benzylsulfinyl)ethyl pyridin-3-ylmethylcarbamodithioate","C584447",0,0,2,0,0,0,0]
["2-(methacryloyloxy)ethyl phosphate","2-(methacryloyloxy)ethyl phosphate","C454021",0,0,2,0,0,0,0]
["2-(N-(2-hydroxyethyl)amino)methyl-3H-quinazolin-4-one","2-(N-(2-hydroxyethyl)amino)methyl-3H-quinazolin-4-one","C577340",0,0,0,0,2,0,0]
["2-(N-myristoylamino)-1-phenyl-1-propanol","2-(N-myristoylamino)-1-phenyl-1-propanol","C099657",0,0,0,0,2,0,0]
["2-(quinolin-2-ylmethylene)hydrazinecarbothioamide","2-(quinolin-2-ylmethylene)hydrazinecarbothioamide","C549333",0,0,4,0,2,0,0]
["2,2'-(piperazine-1,4-diyl)bis(N-(quinolin-8-yl)acetamide)","2,2'-(piperazine-1,4-diyl)bis(N-(quinolin-8-yl)acetamide)","C561433",2,0,0,0,0,0,0]
["2,2,3,3-tetrafluoro-1-propanol","2,2,3,3-tetrafluoro-1-propanol","C519792",2,0,0,0,0,0,0]
["2,2',4,4'-tetrahydroxybenzophenone","2,2',4,4'-tetrahydroxybenzophenone","C035476",0,0,2,0,2,0,0]
["2,2,5,7,8-pentamethyl-6-hydroxychroman","2,2,5,7,8-pentamethyl-6-hydroxychroman","C120726",0,0,2,0,0,0,0]
["2,2'-biimidazole","2,2'-biimidazole","C065541",0,0,2,0,2,0,0]
["2,2-bis(bromomethyl)-1,3-propanediol","2,2-bis(bromomethyl)-1,3-propanediol","C060080",2,2,0,0,0,0,0]
["2,2-dimethylcyclopropanecarboxamide","2,2-dimethylcyclopropanecarboxamide","C522704",2,0,0,0,0,0,0]
["2,3,23-trihydroxy-urs-12-ene-28-olic acid","2,3,23-trihydroxy-urs-12-ene-28-olic acid","C000605817",0,0,2,0,2,0,0]
["2,3,4,5-tetrahydro-2,6-pyridinedicarboxylic acid","2,3,4,5-tetrahydro-2,6-pyridinedicarboxylic acid","C048697",0,0,2,0,0,0,0]
["2,3,4-trimethylpentane","2,3,4-trimethylpentane","C053045",0,1,0,0,0,0,0]
["2,3,5-trihydroxy-5-(propylcarbamoyl)cyclohexyl 6-(4-ethoxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoate","2,3,5-trihydroxy-5-(propylcarbamoyl)cyclohexyl 6-(4-ethoxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoate","C000589734",0,0,0,0,2,0,0]
["2,3-bis(2-hydroxyethylsulfanyl)-(1,4)naphthoquinone","2,3-bis(2-hydroxyethylsulfanyl)-(1,4)naphthoquinone","C451261",0,0,1,0,2,0,0]
["2,3-diaminonaphthalene","2,3-diaminonaphthalene","C026373",6,0,0,0,0,0,0]
["2,3-dichloro-1-propanol","2,3-dichloro-1-propanol","C076159",2,0,2,0,0,0,0]
["2,3-dihydro-2,5-dihydroxy-6-methyl-4H-pyran-4-one","2,3-dihydro-2,5-dihydroxy-6-methyl-4H-pyran-4-one","C427244",0,0,2,0,2,0,0]
["2,3-dihydroxyterephthalamide","2,3-dihydroxyterephthalamide","C435763",2,0,0,0,0,0,0]
["2,3-dinor-6-ketoprostaglandin F1alpha","2,3-dinor-6-ketoprostaglandin F1alpha","C028290",4,0,0,0,2,0,0]
["2,3-naphthoquinone-3-methide","2,3-naphthoquinone-3-methide","C545848",2,0,0,0,0,0,0]
["2,4,4-trimethylpentene","2,4,4-trimethylpentene","C509682",2,0,0,0,0,0,0]
["2,4',5-trichlorobiphenyl","2,4',5-trichlorobiphenyl","C015550",0,0,0,0,2,0,0]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C3396,B3396)","v":"2,4,6-tribromophenol"},"2,4,6-tribromophenol","C004554",6,0,0,0,0,0,0]
["2,4,6-trimercaptotriazine","2,4,6-trimercaptotriazine","C447403",2,0,0,0,0,0,0]
["2,4-bis(p-hydroxyphenyl)-2-butenal","2,4-bis(p-hydroxyphenyl)-2-butenal","C580808",0,0,12,0,10,0,0]
["2,4-dichloroaniline","2,4-dichloroaniline","C054619",2,0,0,0,0,0,0]
["2,4-difluoro-N-(2-(methyloxy)-5-(4-(4-pyridazinyl)-6-quinolinyl)-3-pyridinyl)benzenesulfonamide","2,4-difluoro-N-(2-(methyloxy)-5-(4-(4-pyridazinyl)-6-quinolinyl)-3-pyridinyl)benzenesulfonamide","C561454",0,0,5,0,4,0,0]
["2',4'-dihydroxychalcone","2',4'-dihydroxychalcone","C059354",0,0,2,0,6,0,0]
["2',4'-dinitrophenyl 2-deoxy-2-fluorogalactopyranoside","2',4'-dinitrophenyl 2-deoxy-2-fluorogalactopyranoside","C074857",2,0,0,0,0,0,0]
["2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid","2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid","C488288",0,0,13,1,30,0,0]
["2,5-diazabicyclo(2.2.2)octane","2,5-diazabicyclo(2.2.2)octane","C000619635",0,0,2,0,2,0,0]
["2,5-dimethylisosorbide","2,5-dimethylisosorbide","C040079",2,0,0,0,0,0,0]
["2,5-dimethylpyrrolylbenzoic acid","2,5-dimethylpyrrolylbenzoic acid","C000611121",0,0,2,0,0,0,0]
["2,6-diacetylpyridine bis((4)N-methylthiosemicarbazone)","2,6-diacetylpyridine bis((4)N-methylthiosemicarbazone)","C000591678",0,0,2,0,0,0,0]
["2,6-diamino-9-benzyl-9-deazapurine","2,6-diamino-9-benzyl-9-deazapurine","C495614",0,0,2,0,0,0,0]
["2,6-dichlorophenyl-3,3-bis(indolyl)methane","2,6-dichlorophenyl-3,3-bis(indolyl)methane","C549636",2,0,0,0,0,0,0]
["2,6-dimethyl-5-methoxycarbonyl-4-(2'-nitrophenyl)pyridine-3-carboxylic acid","2,6-dimethyl-5-methoxycarbonyl-4-(2'-nitrophenyl)pyridine-3-carboxylic acid","C534548",0,0,0,0,2,0,0]
["2,6-N,N'-methyl-quinolinio-3-yl-pyridine dicarboxamide","2,6-N,N'-methyl-quinolinio-3-yl-pyridine dicarboxamide","C502660",0,0,2,0,2,0,0]
["2',7'-dichlorofluoresceinylphosphatidylethanolamine","2',7'-dichlorofluoresceinylphosphatidylethanolamine","C059738",2,0,0,0,0,0,0]
["2,9-dibutyl-1,10-phenanthroline","2,9-dibutyl-1,10-phenanthroline","C443419",0,0,0,0,2,0,0]
["20-alpha-dihydrodydrogesterone","20-alpha-dihydrodydrogesterone","C514239",0,0,0,0,2,0,0]
["22,26-azasterol","22,26-azasterol","C103731",0,0,2,0,0,0,0]
["22-1-1 antigen","22-1-1 antigen","C099099",0,0,0,0,2,0,0]
["24-diamino-5-phenylthiazole","24-diamino-5-phenylthiazole","C000612000",0,0,2,0,0,0,0]
["2-5,6,7,8,4'-pentamethoxyflavanone","2-5,6,7,8,4'-pentamethoxyflavanone","C544133",0,0,2,0,2,0,0]
["25-methoxyhispidol A","25-methoxyhispidol A","C569903",0,0,2,0,0,0,0]
["26-trifluoro-(E)-9,10-dehydro-12,13-desoxyepothilone B","26-trifluoro-(E)-9,10-dehydro-12,13-desoxyepothilone B","C493047",0,0,2,0,2,0,0]
["2-acetamido-2-deoxy-6-O-(2,2-bis(hydroxymethyl)-3-hydroxypropyl)glucopyranoside","2-acetamido-2-deoxy-6-O-(2,2-bis(hydroxymethyl)-3-hydroxypropyl)glucopyranoside","C473670",0,0,2,0,0,0,0]
["2-acetylpyridine","2-acetylpyridine","C543930",0,0,2,0,4,0,0]
["2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline","2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline","C036990",10,1,5,0,2,13,0]
["2-amino-3-cyano-7-(dimethylamino)-4-(3-methoxy-4,5-methylenedioxyphenyl)-4H-chromene","2-amino-3-cyano-7-(dimethylamino)-4-(3-methoxy-4,5-methylenedioxyphenyl)-4H-chromene","C494722",0,0,4,0,3,0,0]
["2-amino-4-boronobutanoic acid","2-amino-4-boronobutanoic acid","C426904",2,0,0,0,2,0,0]
["2-amino-4-picoline","2-amino-4-picoline","C015672",0,1,0,0,0,0,0]
["2-amino-6-methyldipyrido(1,2-a-3',2'-d)imidazole","2-amino-6-methyldipyrido(1,2-a-3',2'-d)imidazole","C023785",6,0,0,0,0,5,0]
["2-amino-delta(2)-thiazoline-4-carboxylic acid","2-amino-delta(2)-thiazoline-4-carboxylic acid","C015674",2,0,0,0,0,0,0]
["2-aminomethyl-4-tert-butyl-6-propionylphenol","2-aminomethyl-4-tert-butyl-6-propionylphenol","C037467",2,0,0,0,0,0,0]
["2-Aminopurine","2-Aminopurine","D015075",26,1,4,0,15,7,0]
["2-aziridin-1-yl-3-((2-((2-(3-aziridin-1-yl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)thio)ethoxy)ethyl)thio)naphthoquinone","2-aziridin-1-yl-3-((2-((2-(3-aziridin-1-yl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)thio)ethoxy)ethyl)thio)naphthoquinone","C507359",0,0,0,0,1,0,0]
["2-benzoquinone dioxime","2-benzoquinone dioxime","C039169",2,0,0,0,0,0,0]
["2-bromo-5-(2-bromo-2-nitrovinyl)furan","2-bromo-5-(2-bromo-2-nitrovinyl)furan","C577632",0,0,2,0,0,0,0]
["2-butenal","2-butenal","C012796",10,5,0,0,11,5,0]
["2-carboxyarabinitol","2-carboxyarabinitol","C091324",2,0,0,0,0,0,0]
["2-chloro-4-methylthiobutanoic acid","2-chloro-4-methylthiobutanoic acid","C093068",2,1,0,0,0,0,0]
["2-chloro-5-nitrobenzanilide","2-chloro-5-nitrobenzanilide","C457499",0,0,8,1,9,0,0]
["2-chloro-N-(2-(1-oxo-3-(p-toly)pyrrolo(1,2-a)pyrazin-2(1H)-yl)acetamide","2-chloro-N-(2-(1-oxo-3-(p-toly)pyrrolo(1,2-a)pyrazin-2(1H)-yl)acetamide","C000592921",0,0,2,0,2,0,0]
["2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-hepten-6-ynamide","2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-hepten-6-ynamide","C115284",2,0,6,0,0,0,0]
["2-cyanoacetamide","2-cyanoacetamide","C031594",10,0,2,0,0,0,0]
["2-deoxy-7-O-methyllemnacarnol","2-deoxy-7-O-methyllemnacarnol","C528522",0,0,2,0,0,0,0]
["2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole","2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole","C492322",0,0,7,0,9,0,0]
["2-ethanolamino-2-demethoxy-17-ethanolimino-hypocrellin B","2-ethanolamino-2-demethoxy-17-ethanolimino-hypocrellin B","C578600",0,0,0,0,2,0,0]
["2-ethylhexanol","2-ethylhexanol","C034017",0,2,2,0,0,0,0]
["2-fluoro-3-(2-azetidinylmethoxy)pyridine","2-fluoro-3-(2-azetidinylmethoxy)pyridine","C119803",2,1,0,0,0,2,0]
["2-fluorobenzoic acid","2-fluorobenzoic acid","C022894",2,0,0,0,0,0,0]
["2-heptyl-3-hydroxy-4-quinolone","2-heptyl-3-hydroxy-4-quinolone","C407944",2,0,1,0,1,0,0]
["2-hexadecynoic acid","2-hexadecynoic acid","C031203",0,0,4,0,2,0,0]
["2-hydroxy-3',4,5'-trimethoxystilbene","2-hydroxy-3',4,5'-trimethoxystilbene","C561464",0,0,2,0,2,0,0]
["2-hydroxy-5-nitro-alpha-toluenesulfonic acid","2-hydroxy-5-nitro-alpha-toluenesulfonic acid","C044452",0,0,0,1,0,0,0]
["2-hydroxybutyric acid","2-hydroxybutyric acid","C031570",2,0,0,0,1,0,0]
["2-hydroxyethyl methacrylate phosphate","2-hydroxyethyl methacrylate phosphate","C026575",0,0,1,0,0,0,0]
["2-hydroxymethyl-4-(4-(N,N-dimethylaminosulfonyl)-1-piperazino)pyrimidine","2-hydroxymethyl-4-(4-(N,N-dimethylaminosulfonyl)-1-piperazino)pyrimidine","C106112",2,0,0,0,0,0,0]
["2-Hydroxypropyl-beta-cyclodextrin","2-Hydroxypropyl-beta-cyclodextrin","D000073738",206,12,26,1,13,0,0]
["2-isopropylmalic acid","2-isopropylmalic acid","C502920",4,0,0,0,0,0,0]
["2-isopropylphenol","2-isopropylphenol","C091238",2,0,0,0,0,0,0]
["2-mercaptothiazoline","2-mercaptothiazoline","C005104",2,0,0,0,0,0,0]
["2-methoxy-5-(2-(3,4,5-trimethoxyphenyl)thiophen-3-yl)aniline","2-methoxy-5-(2-(3,4,5-trimethoxyphenyl)thiophen-3-yl)aniline","C575717",0,0,2,0,4,0,0]
["2-methoxyjuglone","2-methoxyjuglone","C582936",0,0,0,0,2,0,0]
["2-methyl-1,4-hydroquinone","2-methyl-1,4-hydroquinone","C062397",0,0,2,0,2,1,0]
["2-methyl-3-hydroxy-4-pyridinecarboxylic acid","2-methyl-3-hydroxy-4-pyridinecarboxylic acid","C529743",0,0,0,0,2,0,0]
["2-methyl-5-(1-methylethyl)bicyclo(3.1.0)hexan-2-ol","2-methyl-5-(1-methylethyl)bicyclo(3.1.0)hexan-2-ol","C534325",0,0,2,0,0,0,0]
["2-methylbutanoic acid","2-methylbutanoic acid","C019475",4,0,0,0,0,0,0]
["2-methyl-N-benzenesulfonyl-N(4)-bromoacetylquinonediimide","2-methyl-N-benzenesulfonyl-N(4)-bromoacetylquinonediimide","C014090",2,0,0,0,0,0,0]
["2-N,N-diethylaminocarbonyloxymethyl-1-diphenylmethyl-4-(3,4,5-trimethoxybenzoyl)piperazine","2-N,N-diethylaminocarbonyloxymethyl-1-diphenylmethyl-4-(3,4,5-trimethoxybenzoyl)piperazine","C549421",0,0,2,0,4,0,0]
["2-n-butylmalonate","2-n-butylmalonate","C006860",2,0,0,0,0,0,0]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C4228,B4228)","v":"2-nitrobenzaldehyde"},"2-nitrobenzaldehyde","C043850",6,0,0,0,0,0,0]
["2-nitrophenyl selenocyanic acid","2-nitrophenyl selenocyanic acid","C044301",2,0,0,0,0,0,0]
["2-nonenal","2-nonenal","C013166",0,0,0,0,1,0,0]
["2-octanone","2-octanone","C037075",6,0,0,0,0,0,0]
["2-O-talopyranosylmannopyranoside","2-O-talopyranosylmannopyranoside","C050370",2,0,0,0,0,0,0]
["2-pentenenitrile","2-pentenenitrile","C062712",0,2,0,0,0,0,0]
["2-phenylethylenesulfonamide","2-phenylethylenesulfonamide","C545662",0,0,0,0,3,2,0]
["2-phenylpyridine","2-phenylpyridine","C058324",0,0,2,0,0,0,0]
["2-p-tolyl-3,4-dihydro-2H-benzo(h)chromene-5,6-dione","2-p-tolyl-3,4-dihydro-2H-benzo(h)chromene-5,6-dione","C588158",0,0,2,0,2,0,0]
["2-succinyl-6-hydroxycyclohexa-2,4-diene-1-carboxylic acid","2-succinyl-6-hydroxycyclohexa-2,4-diene-1-carboxylic acid","C087010",2,0,0,0,0,0,0]
["2-tert-butylhydroquinone","2-tert-butylhydroquinone","C018855",8,2,8,0,47,1,0]
["2-thiopyridine","2-thiopyridine","C029347",4,0,0,0,0,0,0]
["2-undecylsulfonyl-5,8-dimethoxy-1,4-naphthoquinone","2-undecylsulfonyl-5,8-dimethoxy-1,4-naphthoquinone","C000594165",0,0,2,0,0,0,0]
["3-((2-benzyl-6-(3-hydroxy-4-methoxypyrrolidin-1-yl)pyridin-3-yl)ethynyl)quinuclidin-3-ol","3-((2-benzyl-6-(3-hydroxy-4-methoxypyrrolidin-1-yl)pyridin-3-yl)ethynyl)quinuclidin-3-ol","C489151",0,0,2,0,0,0,0]
["3-((4-(6-bromo-2-(4-(4-methylpiperazin-1-yl)phenyl)-3H-imidazo(4,5-b)pyridin-7-yl)piperazin-1-yl)methyl)-5-methylisoxazole","3-((4-(6-bromo-2-(4-(4-methylpiperazin-1-yl)phenyl)-3H-imidazo(4,5-b)pyridin-7-yl)piperazin-1-yl)methyl)-5-methylisoxazole","C551619",0,1,3,0,4,0,0]
["3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide","3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide","C000590771",0,0,2,0,2,0,0]
["3-(1-(1-(benzo(d)oxazol-2-yl)-2-methylpropyl)-1H-1,2,3-triazol-4-yl)-N-hydroxyacrylamide","3-(1-(1-(benzo(d)oxazol-2-yl)-2-methylpropyl)-1H-1,2,3-triazol-4-yl)-N-hydroxyacrylamide","C574634",0,0,4,0,4,0,0]
["3'-(1-chloroethyl)-2,3-dihydro-1H-imidazo(2,1-i)purine-4-ium-7-yl-3'-deoxy-1',5',6'-tri-O-(methylsulfonyl)-muco-inositol chloride","3'-(1-chloroethyl)-2,3-dihydro-1H-imidazo(2,1-i)purine-4-ium-7-yl-3'-deoxy-1',5',6'-tri-O-(methylsulfonyl)-muco-inositol chloride","C118646",0,0,0,1,0,0,0]
["3-(2-((3,4-dihydroxyphenyl)-(4-(2-dimethylaminoethyl)imidazol-1-yl)methyl)benzo(1,3)dioxol-5-yl)propionic acid","3-(2-((3,4-dihydroxyphenyl)-(4-(2-dimethylaminoethyl)imidazol-1-yl)methyl)benzo(1,3)dioxol-5-yl)propionic acid","C000607981",0,0,0,2,0,0,0]
["3-(2-(4-(3-guanidinopropyl)(1,2,3)triazol-1-yl)acetylamino)-3-phenylpropionic acid","3-(2-(4-(3-guanidinopropyl)(1,2,3)triazol-1-yl)acetylamino)-3-phenylpropionic acid","C553292",0,0,0,1,0,0,0]
["3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone","3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone","C549041",0,0,2,0,36,0,0]
["3-(2-aminoethyl)-5-(3-(4-butoxylphenyl)propylidene)thiazolidine-2,4-dione","3-(2-aminoethyl)-5-(3-(4-butoxylphenyl)propylidene)thiazolidine-2,4-dione","C583313",0,0,2,0,2,0,0]
["3-(3-(4-methylpiperazin-1-yl)cyclobutyl)-1-(2-phenylquinolin-7-yl)imidazo(1,5-a)pyrazin-8-ylamine","3-(3-(4-methylpiperazin-1-yl)cyclobutyl)-1-(2-phenylquinolin-7-yl)imidazo(1,5-a)pyrazin-8-ylamine","C523453",0,0,4,0,2,0,0]
["3-(3,4,5-trimethoxyphenylselenyl)-1H-indole","3-(3,4,5-trimethoxyphenylselenyl)-1H-indole","C000601655",0,0,2,0,0,0,0]
["3-(3-hydroxy-4-methoxyphenyl)-4-(3,4,5-trimethoxyphenyl)-1,2,5-selenadiazole","3-(3-hydroxy-4-methoxyphenyl)-4-(3,4,5-trimethoxyphenyl)-1,2,5-selenadiazole","C000596773",0,0,0,0,2,0,0]
["3-(4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-ylcarbonyl)thiazolidine","3-(4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-ylcarbonyl)thiazolidine","C579035",0,0,2,0,2,0,0]
["3-(4'-acetoxy-3',5'-dimethoxy)benzylidene-1,2-dihydropyrrolo(2,1-b)quinazoline-9-one","3-(4'-acetoxy-3',5'-dimethoxy)benzylidene-1,2-dihydropyrrolo(2,1-b)quinazoline-9-one","C451659",0,0,1,0,1,0,0]
["3-(4-chloro-3-nitrobenzylidene)pentane-2,4-dione","3-(4-chloro-3-nitrobenzylidene)pentane-2,4-dione","C511620",0,0,0,0,2,0,0]
["3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid","3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid","C472791",0,0,10,0,21,0,0]
["3-(4-nitro-3-(trifluoromethyl)phenyl)-3a,4,5,6,7,7a-hexahydrobenzo(d)isoxazole","3-(4-nitro-3-(trifluoromethyl)phenyl)-3a,4,5,6,7,7a-hexahydrobenzo(d)isoxazole","C000593238",0,0,2,0,0,0,0]
["3-(5-nitro-2-hydroxybenzylideneamino)-2-(5-nitro-2-hydroxyphenyl)-2,3-dihydroquinazolin-4(1H)-one","3-(5-nitro-2-hydroxybenzylideneamino)-2-(5-nitro-2-hydroxyphenyl)-2,3-dihydroquinazolin-4(1H)-one","C000608778",0,0,0,0,2,0,0]
["3-(cis-2,6-dimethylpiperidino)sydnonimine","3-(cis-2,6-dimethylpiperidino)sydnonimine","C072857",2,0,0,0,0,0,0]
["3-(hydroxymethyl)phenytoin","3-(hydroxymethyl)phenytoin","C043104",2,0,0,0,0,0,0]
["3-(N-phenylamino)-1,2-propanediol 1-oleoyl ester","3-(N-phenylamino)-1,2-propanediol 1-oleoyl ester","C092834",0,0,0,0,1,0,0]
["3-(trimethylsilyl)propanesulfonic acid","3-(trimethylsilyl)propanesulfonic acid","C009580",2,0,0,0,0,0,0]
["3,16-dihydroxyandrost-5-ene-17,19-dione","3,16-dihydroxyandrost-5-ene-17,19-dione","C066747",0,0,2,0,0,0,0]
["3,3',4,4',5,5'-hexamethoxystilbene","3,3',4,4',5,5'-hexamethoxystilbene","C000616258",0,0,2,0,0,0,0]
["3,3',5,5'-tetrabromo-m-cresojsulphonphthalein","3,3',5,5'-tetrabromo-m-cresojsulphonphthalein","C549155",2,0,0,0,0,0,0]
["3,3'-dihexyl-2,2'-oxacarbocyanine","3,3'-dihexyl-2,2'-oxacarbocyanine","C007392",0,0,0,0,2,0,0]
["3,3'-diselenodipropionic acid","3,3'-diselenodipropionic acid","C524945",0,0,1,0,10,0,0]
["3,4,5,6-tetrabromophenolsulfonephthalein","3,4,5,6-tetrabromophenolsulfonephthalein","C076970",2,0,0,0,0,0,0]
["3',4',6'-tri-O-feruloylsucrose","3',4',6'-tri-O-feruloylsucrose","C581085",0,0,2,0,0,0,0]
["3,4'-bis-(4-hydroxycoumarin-3-yl)-2,5-hexanediol","3,4'-bis-(4-hydroxycoumarin-3-yl)-2,5-hexanediol","C576529",2,0,0,0,0,0,0]
["3',4'-didemethylnobiletin","3',4'-didemethylnobiletin","C534647",0,0,0,0,2,0,0]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C4740,B4740)","v":"3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone"},"3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone","C108729",0,0,2,1,4,0,0]
["3,4-dihydroxybenzohydroxamic acid","3,4-dihydroxybenzohydroxamic acid","C035419",2,0,2,0,11,0,0]
["3,4-dihydroxyphenyllactic acid","3,4-dihydroxyphenyllactic acid","C035055",4,0,14,2,30,0,0]
["3,4-epoxy-5alpha-androstan-17-one","3,4-epoxy-5alpha-androstan-17-one","C505558",0,0,2,0,0,0,0]
["3,5,3',4',5'-pentamethoxystilbene","3,5,3',4',5'-pentamethoxystilbene","C494914",0,0,2,0,0,0,0]
["3,5-bis(2-fluorobenzylidene)piperidin-4-one","3,5-bis(2-fluorobenzylidene)piperidin-4-one","C524042",0,0,22,2,34,0,0]
["3,5-dichlorobenzonitrile","3,5-dichlorobenzonitrile","C543727",2,0,0,0,0,0,0]
["3,5-dimethyl-7H-furo(3,2-g)chromen-7-one","3,5-dimethyl-7H-furo(3,2-g)chromen-7-one","C560573",0,0,0,0,4,0,0]
["3,6,9-trihydroxypterocarpan","3,6,9-trihydroxypterocarpan","C042061",2,0,0,0,0,0,0]
["3,6-epidioxy-1,10-bisaboladiene","3,6-epidioxy-1,10-bisaboladiene","C576517",0,0,2,0,2,0,0]
["3,7,12-trihydroxycoprostanic acid","3,7,12-trihydroxycoprostanic acid","C003681",2,0,0,0,0,0,0]
["3,9-dihydroxypterocarpan","3,9-dihydroxypterocarpan","C042060",2,0,0,0,0,0,0]
["3-acetamido-4-methyl benzoic acid","3-acetamido-4-methyl benzoic acid","C000591486",0,0,2,0,0,0,0]
["3-acetyldeoxynivalenol","3-acetyldeoxynivalenol","C043247",2,0,2,0,2,0,0]
["3alpha,12alpha-dihydroxy-5beta-cholan-24-amine","3alpha,12alpha-dihydroxy-5beta-cholan-24-amine","C530421",2,0,0,0,0,0,0]
["3alpha-O-(beta-D-glucopyranosyl)desoxypodophyllotoxin","3alpha-O-(beta-D-glucopyranosyl)desoxypodophyllotoxin","C000602205",0,0,2,0,0,0,0]
["3-amino-3-(4-fluorophenyl)-1H-quinoline-2,4-dione","3-amino-3-(4-fluorophenyl)-1H-quinoline-2,4-dione","C000591011",0,0,0,0,4,0,0]
["3-amino-6-(3-methoxyphenyl)thieno(2.3-b)pyridine-2-carboxamide","3-amino-6-(3-methoxyphenyl)thieno(2.3-b)pyridine-2-carboxamide","C574230",0,0,2,0,2,0,0]
["3-aminophenol","3-aminophenol","C055528",4,0,0,0,0,0,0]
["3-benzyl-5-((2-nitrophenoxy)methyl)dihydrofuran-2(3H)-one","3-benzyl-5-((2-nitrophenoxy)methyl)dihydrofuran-2(3H)-one","C553471",0,0,0,0,2,0,0]
["3beta-choloro-2'-amino-3'-cyanocholest-6-eno(5,7-de)4H-pyran","3beta-choloro-2'-amino-3'-cyanocholest-6-eno(5,7-de)4H-pyran","C000589409",0,0,0,0,2,0,0]
["3-bromo-2-ketoglutarate","3-bromo-2-ketoglutarate","C029384",2,0,0,0,0,0,0]
["3-bromopyridine","3-bromopyridine","C517741",0,0,1,0,0,0,0]
["3-carboxy-5-methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazolecarboxamide","3-carboxy-5-methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazolecarboxamide","C073586",2,0,0,0,0,0,0]
["3-chloro-2-hydroxy-(3,4-dimethyl-5-isoxazolyl)-1,4-naphthoquinon-4-imine","3-chloro-2-hydroxy-(3,4-dimethyl-5-isoxazolyl)-1,4-naphthoquinon-4-imine","C121800",2,0,0,0,0,0,0]
["3-chlorolactate","3-chlorolactate","C007000",0,0,2,0,0,0,0]
["3-C-methylerythritol","3-C-methylerythritol","C043904",2,0,0,0,0,1,0]
["3-deoxy-3-C-methylene-ribo-hexose-6-phosphate","3-deoxy-3-C-methylene-ribo-hexose-6-phosphate","C440770",2,0,0,0,0,0,0]
["3-dinitrobenzene","3-dinitrobenzene","C017906",4,2,4,0,4,1,0]
["3-ethylpyridine","3-ethylpyridine","C039675",0,0,2,0,0,0,0]
["3-fluorophenol","3-fluorophenol","C085046",2,0,0,0,0,0,0]
["3-hydroxy-17a-azahomoandrostan-7-one-4-N,N-bis(2-chloroethyl)aminophenyl acetate","3-hydroxy-17a-azahomoandrostan-7-one-4-N,N-bis(2-chloroethyl)aminophenyl acetate","C541692",0,0,2,0,2,0,0]
["3-hydroxy-3-methylbutene","3-hydroxy-3-methylbutene","C027250",2,0,0,0,0,0,0]
["3-hydroxy-4-methoxy-beta-methyl-beta-nitrostyrene","3-hydroxy-4-methoxy-beta-methyl-beta-nitrostyrene","C512238",0,0,6,0,4,0,0]
["3-hydroxyandrosta-5,7-diene-17-carboxylic acid","3-hydroxyandrosta-5,7-diene-17-carboxylic acid","C549476",0,0,2,0,0,0,0]
["3-hydroxy-gamma-butyrolactone","3-hydroxy-gamma-butyrolactone","C511346",0,0,1,0,0,0,0]
["3-hydroxyphysodic acid","3-hydroxyphysodic acid","C501217",0,0,2,0,0,0,0]
["3-indolecarboxylic acid","3-indolecarboxylic acid","C000616673",0,0,2,0,2,0,0]
["3-isopropyl-2-methyl-4-methyleneisoxazolidin-5-one","3-isopropyl-2-methyl-4-methyleneisoxazolidin-5-one","C571418",0,0,2,0,4,0,0]
["3-methoxy-11-methyldibenz(b,f)oxazepine-8-carboxylate","3-methoxy-11-methyldibenz(b,f)oxazepine-8-carboxylate","C058844",0,1,0,0,0,0,0]
["3-methoxybenzoic acid","3-methoxybenzoic acid","C056267",2,0,0,0,0,0,0]
["3-methylcatechol","3-methylcatechol","C031136",6,0,0,0,0,1,0]
["3-methylene-2-norbornanone","3-methylene-2-norbornanone","C497854",0,0,0,0,2,0,0]
["3-nitrobenzamidine","3-nitrobenzamidine","C025392",0,0,0,0,2,0,0]
["3-N-methylspiperone","3-N-methylspiperone","C039167",2,1,0,0,0,0,0]
["3-O-(3,4,5-trimethoxybenzoyl)catechin","3-O-(3,4,5-trimethoxybenzoyl)catechin","C559677",2,0,0,0,0,0,0]
["3-O-(N-(p-fluorobenzenesulfonyl)carbamoyl)oleanolic acid","3-O-(N-(p-fluorobenzenesulfonyl)carbamoyl)oleanolic acid","C000602451",0,0,2,0,2,0,0]
["3-O-desmethyl-13a-deoxytylophorinine","3-O-desmethyl-13a-deoxytylophorinine","C000605938",0,0,3,0,0,0,0]
["3-O-methylsphingomyelin","3-O-methylsphingomyelin","C508074",0,0,0,0,2,0,0]
["3-oxo-abieta-13-ene","3-oxo-abieta-13-ene","C000617261",0,0,0,0,2,0,0]
["3-oxo-tirucall-8,24-dien-21-oic acid","3-oxo-tirucall-8,24-dien-21-oic acid","C432163",0,0,0,0,2,0,0]
["3-phenylpropyl caffeate","3-phenylpropyl caffeate","C000602374",0,0,2,0,0,0,0]
["3-sulfoglucuronyl-lacto-N-norhexaosylceramide","3-sulfoglucuronyl-lacto-N-norhexaosylceramide","C063679",2,0,0,0,0,0,0]
["3-toluoyl dimethylaminoethanol","3-toluoyl dimethylaminoethanol","C026354",2,0,0,0,0,0,0]
["4-((3-(1,6-dihyro-6-oxo-9H-purin-9-yl)-1-oxopropyl)amino)benzoic acid","4-((3-(1,6-dihyro-6-oxo-9H-purin-9-yl)-1-oxopropyl)amino)benzoic acid","C086241",0,0,0,0,4,0,0]
["4-((4-fluoro-2-isopropoxyphenyl)amino)-N-(2-methoxyethyl)-5-methylthieno(2,3-d)pyrimidine-6-carboxamide","4-((4-fluoro-2-isopropoxyphenyl)amino)-N-(2-methoxyethyl)-5-methylthieno(2,3-d)pyrimidine-6-carboxamide","C000601057",0,0,2,0,0,0,0]
["4-((alpha-L-rhamnosyloxy)benzyl)isothiocyanate","4-((alpha-L-rhamnosyloxy)benzyl)isothiocyanate","C000600309",0,0,0,0,6,0,0]
["4-(1H-imidazol-1-yl)retinoic acid methyl ester","4-(1H-imidazol-1-yl)retinoic acid methyl ester","C575619",0,0,0,0,2,0,0]
["4-(2-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)-1-propenyl)benzoic acid","4-(2-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)-1-propenyl)benzoic acid","C525646",0,0,0,0,1,0,0]
["4-(2-butyl-6,7-dichlor-2-cyclopentyl-indan-1-one-5-yl)oxybutyric acid","4-(2-butyl-6,7-dichlor-2-cyclopentyl-indan-1-one-5-yl)oxybutyric acid","C443139",0,0,2,0,0,0,0]
["4-(3'-(1-adamantyl)-4'-hydroxyphenyl)-3-(3'-acetamidopropyloxy)cinnamic acid","4-(3'-(1-adamantyl)-4'-hydroxyphenyl)-3-(3'-acetamidopropyloxy)cinnamic acid","C488108",0,0,0,0,2,0,0]
["4-(3-(2-nitro-1-imidazolyl)-propylamino)-7-chloroquinoline hydrochloride","4-(3-(2-nitro-1-imidazolyl)-propylamino)-7-chloroquinoline hydrochloride","C434187",0,0,0,0,2,0,0]
["4-(3-amino-4-(2,4,5-trifluorophenyl)butanoyl)-3-(tert-butoxymethyl)piperazin-2-one","4-(3-amino-4-(2,4,5-trifluorophenyl)butanoyl)-3-(tert-butoxymethyl)piperazin-2-one","C557982",0,0,2,0,0,0,0]
["4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl 2-((4-(nitrooxy)butanoyl)oxy)benzoate","4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl 2-((4-(nitrooxy)butanoyl)oxy)benzoate","C571898",0,0,6,0,6,0,0]
["4-(4-(4-chloro-phenyl)thiazol-2-ylamino)phenol","4-(4-(4-chloro-phenyl)thiazol-2-ylamino)phenol","C525025",0,0,12,0,19,0,0]
["4-(4-acetyl-4,5-dihydro-5-(3,4,5-trimethoxyphenyl)-1,3,4-oxadiazol-2-yl)-N,N-dimethylbenzeneamine","4-(4-acetyl-4,5-dihydro-5-(3,4,5-trimethoxyphenyl)-1,3,4-oxadiazol-2-yl)-N,N-dimethylbenzeneamine","C431623",0,0,0,0,2,0,0]
["4-(4-dimethylaminostyryl)-1-methylpyridinium","4-(4-dimethylaminostyryl)-1-methylpyridinium","C032315",2,0,0,0,0,0,0]
["4-(5-(6-(3-chlorophenylamino)pyrazin-2-yl)pyridin-3-ylamino)butan-1-ol","4-(5-(6-(3-chlorophenylamino)pyrazin-2-yl)pyridin-3-ylamino)butan-1-ol","C502987",0,0,2,0,0,0,0]
["4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)benzoic acid","4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)benzoic acid","C064545",2,1,0,2,2,0,0]
["4-(6-hydroxy-7-tricyclo(3.3.1.13,7)dec-1-yl-2-naphthalenyl)benzoic acid","4-(6-hydroxy-7-tricyclo(3.3.1.13,7)dec-1-yl-2-naphthalenyl)benzoic acid","C000591478",0,0,1,0,0,0,0]
["4-(benzyloxy)-1-phenylbut-2-yn-1-ol","4-(benzyloxy)-1-phenylbut-2-yn-1-ol","C572362",0,0,2,0,0,0,0]
["4-(dimethylamino)naphthalene-1-boronic acid","4-(dimethylamino)naphthalene-1-boronic acid","C485394",2,0,0,0,0,0,0]
["4-(isopropylamino)-2-(2-pyridyl)-2-phenylbutyramide","4-(isopropylamino)-2-(2-pyridyl)-2-phenylbutyramide","C030438",2,0,0,0,0,0,0]
["4-(ribofuranosyl)aminobenzene 5'-phosphate","4-(ribofuranosyl)aminobenzene 5'-phosphate","C114049",2,0,0,0,0,0,0]
["4,4'-(1,2-dimethyl-1,2-ethanediyl)bis-2,6-piperazinedione","4,4'-(1,2-dimethyl-1,2-ethanediyl)bis-2,6-piperazinedione","C070899",0,0,2,0,9,2,0]
["4,4'-diaminobenzanilide","4,4'-diaminobenzanilide","C033740",0,0,0,0,0,1,0]
["4,4'-dithiodimorpholine","4,4'-dithiodimorpholine","C013975",0,0,0,0,2,0,0]
["4,4'-methylenebis(2,6-diisopropylaniline)","4,4'-methylenebis(2,6-diisopropylaniline)","C043627",2,0,0,0,0,0,0]
["4,5-dihydropyrazole-1-carbothioamide","4,5-dihydropyrazole-1-carbothioamide","C559799",0,0,2,0,0,0,0]
["4,5-epoxymorphinan","4,5-epoxymorphinan","C496139",0,0,4,0,0,0,0]
["4,6-dinitro-o-cresol","4,6-dinitro-o-cresol","C024132",12,0,0,0,4,0,0]
["4,8-dioctyl-3,9-dioxo-6-hydroxy-4,8-diaza-1,11-undecanedicarboxylate","4,8-dioctyl-3,9-dioxo-6-hydroxy-4,8-diaza-1,11-undecanedicarboxylate","C522046",2,0,0,0,0,0,0]
["4-acetylantroquinonol B","4-acetylantroquinonol B","C555021",0,0,10,0,2,0,0]
["4-amino-2-phenoxymethanesulfonanilide","4-amino-2-phenoxymethanesulfonanilide","C108971",2,0,0,0,0,0,0]
["4-amino-5-benzoyl-2-(4-methoxyphenylamino)thiazole","4-amino-5-benzoyl-2-(4-methoxyphenylamino)thiazole","C496402",0,0,4,1,6,0,0]
["4-aminodiphenylamine","4-aminodiphenylamine","C031506",2,0,0,0,0,0,0]
["4-aminophenylphosphate","4-aminophenylphosphate","C068798",8,0,0,0,0,0,0]
["4-aminopyrrolopyrimidine","4-aminopyrrolopyrimidine","C584284",0,0,2,0,0,0,0]
["4-aza-2,3-didehydropodophyllotoxin","4-aza-2,3-didehydropodophyllotoxin","C467920",0,0,0,0,4,0,0]
["4-biphenylamine","4-biphenylamine","C006757",6,0,0,0,2,7,0]
["4-bromophenacyl bromide","4-bromophenacyl bromide","C006821",10,1,3,2,4,0,0]
["4-chloro-1,2-diaminobenzene","4-chloro-1,2-diaminobenzene","C015060",0,0,0,0,2,0,0]
["4-chlorobiphenyl","4-chlorobiphenyl","C006983",2,0,2,0,0,0,0]
["4-chloro-N-((2-chlorophenyl)(2-methyl-1H-indol-3-yl)methyl)aniline","4-chloro-N-((2-chlorophenyl)(2-methyl-1H-indol-3-yl)methyl)aniline","C000604910",0,0,2,0,2,0,0]
["4-chloro-N-(hydroxymethyl)benzamide","4-chloro-N-(hydroxymethyl)benzamide","C050284",2,0,0,0,0,0,0]
["4-cyclododecyl-2,6-dimethylmorpholine acetate","4-cyclododecyl-2,6-dimethylmorpholine acetate","C077547",2,0,0,0,0,0,0]
["4-deoxypyridoxine","4-deoxypyridoxine","C004675",0,0,0,0,4,0,0]
["4-dichlorobenzene","4-dichlorobenzene","C018511",2,2,2,0,2,0,0]
["4EGI-1 compound","4EGI-1 compound","C517852",0,0,14,0,12,0,0]
["4-fluoro-2-(5-(2-hydroxy-1-phenylethylamino)-3-(3-methyl-1H-indazol-5-yl)pyridin-2-yl)phenol","4-fluoro-2-(5-(2-hydroxy-1-phenylethylamino)-3-(3-methyl-1H-indazol-5-yl)pyridin-2-yl)phenol","C000622275",0,0,2,0,0,0,0]
["4-geranyloxy-1-(2-methylbutanoyl)phloroglucinol","4-geranyloxy-1-(2-methylbutanoyl)phloroglucinol","C546529",0,0,2,0,0,0,0]
["4-hydroxy-2-hexenal","4-hydroxy-2-hexenal","C045934",2,2,0,0,4,0,0]
["4-hydroxy-5-methylene-3-undecyclidenedihydrofuran-2(3H)-one","4-hydroxy-5-methylene-3-undecyclidenedihydrofuran-2(3H)-one","C585128",0,0,2,0,2,0,0]
["4-hydroxybenzaldehyde","4-hydroxybenzaldehyde","C011483",2,0,4,0,0,0,0]
["4'-hydroxydiclofenac","4'-hydroxydiclofenac","C108036",0,0,2,0,0,0,0]
["4-hydroxylevamisole","4-hydroxylevamisole","C048326",2,0,0,0,0,0,0]
["4-hydroxymidazolam","4-hydroxymidazolam","C042940",2,0,0,0,0,0,0]
["4-hydroxyquinoline","4-hydroxyquinoline","C034010",4,0,0,0,0,0,0]
["4-isopropylbenzaldehyde thiosemicarbazone","4-isopropylbenzaldehyde thiosemicarbazone","C111909",0,0,0,0,4,0,0]
["4-isopropylphenol","4-isopropylphenol","C028690",4,1,0,0,0,0,0]
["4-methoxybenzenediazonium","4-methoxybenzenediazonium","C519293",2,0,0,0,0,0,0]
["4-methoxymandelic acid","4-methoxymandelic acid","C066949",2,0,0,0,0,0,0]
["4-methyl-5-(4-pyridinyl)-2(3H)-oxazolone","4-methyl-5-(4-pyridinyl)-2(3H)-oxazolone","C076169",0,0,0,1,0,0,0]
["4-methylcyclohexylamine","4-methylcyclohexylamine","C059116",2,0,2,0,0,0,0]
["4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((1-nicotinoylpiperidin-4-yl)oxy)benzamide","4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((1-nicotinoylpiperidin-4-yl)oxy)benzamide","C000621653",0,0,2,0,2,0,0]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C6084,B6084)","v":"4-methylthiazole-5-carboxylic acid"},"4-methylthiazole-5-carboxylic acid","C000596735",0,0,2,0,0,0,0]
["4-N,N-dimethylaminoazobenzene-4'-sulfonyl chloride","4-N,N-dimethylaminoazobenzene-4'-sulfonyl chloride","C010572",6,0,0,0,0,0,0]
["4-nitroaniline","4-nitroaniline","C019498",12,0,0,0,0,0,0]
["4-nitroimidazole","4-nitroimidazole","C052587",12,0,2,0,0,0,0]
["4-nitrophenyl butyrate","4-nitrophenyl butyrate","C033592",4,0,0,0,0,0,0]
["4-nitrophenylgalactoside","4-nitrophenylgalactoside","C059200",4,0,0,0,0,0,0]
["4-nitrophenyl-O-6-deoxy-6-((2-pyridyl)amino)-alpha-D-glucopyranosyl-(1-4)-O-alpha-D-glucopyranosyl-(1-4)-O-alpha-D-glucopyranosyl-(1-4)-O-alpha-D-glucopyranosyl-(1-4)-alpha-D-glucopyranoside","4-nitrophenyl-O-6-deoxy-6-((2-pyridyl)amino)-alpha-D-glucopyranosyl-(1-4)-O-alpha-D-glucopyranosyl-(1-4)-O-alpha-D-glucopyranosyl-(1-4)-O-alpha-D-glucopyranosyl-(1-4)-alpha-D-glucopyranoside","C049264",2,0,0,0,0,0,0]
["4-nitrososulfamethoxazole","4-nitrososulfamethoxazole","C072956",0,0,4,0,0,0,0]
["4'-O-methylepigallocatechin","4'-O-methylepigallocatechin","C518873",2,0,0,0,0,0,0]
["4-oxy-6-(4-oxybezoyloxy)dauc-8,9-en","4-oxy-6-(4-oxybezoyloxy)dauc-8,9-en","C111068",2,0,2,0,7,0,0]
["4-palmitoyl-sinomenine","4-palmitoyl-sinomenine","C000591720",0,0,2,0,0,0,0]
["4-propyl-5-(4-pyridinyl)-2(3H)-oxazolone","4-propyl-5-(4-pyridinyl)-2(3H)-oxazolone","C069455",0,0,0,1,0,0,0]
["4-pyridylanilinothiazole","4-pyridylanilinothiazole","C000593071",0,0,2,0,0,0,0]
["4-toluenesulfonamide","4-toluenesulfonamide","C025417",0,3,1,0,2,0,0]
["4-vinyl-2,6-dimethoxyphenol","4-vinyl-2,6-dimethoxyphenol","C488411",0,0,2,0,2,0,0]
["5-((4-methylphenyl)methylene)-2-(phenylamino)-4(5H)-thiazolone","5-((4-methylphenyl)methylene)-2-(phenylamino)-4(5H)-thiazolone","C503119",0,0,4,0,6,0,0]
["5-((5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl)-N-(2-hydroxy-3-morpholin-4-ylpropyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide","5-((5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl)-N-(2-hydroxy-3-morpholin-4-ylpropyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide","C513935",0,0,1,0,0,0,0]
["5-(2,4-dihydroxybenzylidene)-2-(phenylimino)-1,3-thiazolidin","5-(2,4-dihydroxybenzylidene)-2-(phenylimino)-1,3-thiazolidin","C503643",0,0,2,1,4,0,0]
["5-(2-cyclohexylidene-ethyl)-5-ethylbarbiturate","5-(2-cyclohexylidene-ethyl)-5-ethylbarbiturate","C024321",2,0,0,0,0,0,0]
["5-(3-Chloro-4-ethoxyphenyl)-1-(3,4,5-trimethoxyphenyl)-1H-1,2,4-triazole","5-(3-Chloro-4-ethoxyphenyl)-1-(3,4,5-trimethoxyphenyl)-1H-1,2,4-triazole","C550172",0,0,0,0,1,0,0]
["5-(3-hydroxypropyl)-7-methoxy-2-(3'-methoxy-4'-hydroxyphenyl)-3-benzo(b)furancarbaldehyde","5-(3-hydroxypropyl)-7-methoxy-2-(3'-methoxy-4'-hydroxyphenyl)-3-benzo(b)furancarbaldehyde","C481599",0,0,0,0,1,0,0]
["5-(4-acryloyloxyphenyl)-10,15,20-tritolylporphyrin","5-(4-acryloyloxyphenyl)-10,15,20-tritolylporphyrin","C521430",2,0,0,0,0,0,0]
["5-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one","5-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one","C524814",0,0,12,0,12,0,0]
["5-(4-phenylbutoxy)psoralen","5-(4-phenylbutoxy)psoralen","C499898",0,0,1,0,0,0,0]
["5-(6-(5-(difluoro(methylsulfonyl)methyl)-1,3,4-oxadiazol-2-yl)-5-isopropylpyrrolo(2,1-f)(1,2,4)triazin-4-ylamino)-2,4-difluoro-N-methoxybenzamide","5-(6-(5-(difluoro(methylsulfonyl)methyl)-1,3,4-oxadiazol-2-yl)-5-isopropylpyrrolo(2,1-f)(1,2,4)triazin-4-ylamino)-2,4-difluoro-N-methoxybenzamide","C501755",0,0,2,0,0,0,0]
["5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide","5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide","C085754",0,0,1,0,1,0,0]
["5-(N-(4,6-dimethoxypyrimidin-2-ylcarbamoyl)sulfamoyl)-1-methyl-1H-pyrazole-4-carboxylic acid","5-(N-(4,6-dimethoxypyrimidin-2-ylcarbamoyl)sulfamoyl)-1-methyl-1H-pyrazole-4-carboxylic acid","C539324",2,0,0,0,0,0,0]
["5,10,15,20-tetrakis(7-sulfonatobenzo(b)thiophene)porphyrin","5,10,15,20-tetrakis(7-sulfonatobenzo(b)thiophene)porphyrin","C000603348",0,0,0,0,1,0,0]
["5,10-diphenyl-4,9-dimethyl-4,9-diazapyrenium","5,10-diphenyl-4,9-dimethyl-4,9-diazapyrenium","C504891",0,0,0,0,2,0,0]
["5,18-bis(2-hydroxyhexadecyl)-1,5,18,22-tetraazadocosane","5,18-bis(2-hydroxyhexadecyl)-1,5,18,22-tetraazadocosane","C478377",2,0,0,0,0,0,0]
["5,4'-O-beta-D-diglucopyranosyl cirsimaritin","5,4'-O-beta-D-diglucopyranosyl cirsimaritin","C560460",0,0,2,0,0,0,0]
["5,5-dimethyl-3-(alpha,alpha,alpha,4-tetrafluoro-3-tolyl)hydantoin","5,5-dimethyl-3-(alpha,alpha,alpha,4-tetrafluoro-3-tolyl)hydantoin","C037557",2,0,0,0,0,0,0]
["5,6,11,12,17,18-hexahydrocyclononatriindole","5,6,11,12,17,18-hexahydrocyclononatriindole","C074140",4,0,0,0,0,0,0]
["5,6-dihydroxy-2-indolylcarboxylic acid","5,6-dihydroxy-2-indolylcarboxylic acid","C030692",12,0,3,0,5,0,0]
["5,6-dihydroxy-3,7,4'-trimethoxyflavonol","5,6-dihydroxy-3,7,4'-trimethoxyflavonol","C000613445",0,0,0,0,2,0,0]
["5,7,3',4',5'-pentamethoxyflavone","5,7,3',4',5'-pentamethoxyflavone","C488726",0,0,2,0,1,0,0]
["5,7-dihydroxychromone","5,7-dihydroxychromone","C080094",0,0,0,0,2,0,0]
["5,8-dihydroxy-2-(2-(4-methoxyphenyl)ethyl)chromone","5,8-dihydroxy-2-(2-(4-methoxyphenyl)ethyl)chromone","C066414",2,0,0,0,0,0,0]
["5a,9-dimethyl-3-methylene-3,3a,4,5,5a,6,7,8-octahydro-1-oxacyclopenta(c)azulen-2-one","5a,9-dimethyl-3-methylene-3,3a,4,5,5a,6,7,8-octahydro-1-oxacyclopenta(c)azulen-2-one","C513993",0,0,2,0,0,0,0]
["5-amino-1-(1-cyanopiperidin-3-yl)-3-(4-(2,4-difluorophenoxy)phenyl)-1H-pyrazole-4-carboxamide","5-amino-1-(1-cyanopiperidin-3-yl)-3-(4-(2,4-difluorophenoxy)phenyl)-1H-pyrazole-4-carboxamide","C585580",0,0,2,0,0,0,0]
["5-amino-8-hydroxyquinoline","5-amino-8-hydroxyquinoline","C528550",2,0,2,0,2,0,0]
["5-azidoxanthenone-4-acetic acid","5-azidoxanthenone-4-acetic acid","C524098",0,1,0,0,0,0,0]
["5beta-cholestan-3-one","5beta-cholestan-3-one","C500347",0,0,0,0,2,0,0]
["5-chloro-4,5-didehydrojasmonate","5-chloro-4,5-didehydrojasmonate","C553470",0,0,2,0,2,0,0]
["5-deazafolic acid","5-deazafolic acid","C040505",2,0,0,0,0,0,0]
["5-deazariboflavin","5-deazariboflavin","C007228",6,0,0,0,0,0,0]
["5-ethoxycarbonyl-6-methyl-4-(3-nitrophenyl)-3,4-dihydropyrimidin-2-(1H)-thione","5-ethoxycarbonyl-6-methyl-4-(3-nitrophenyl)-3,4-dihydropyrimidin-2-(1H)-thione","C584768",0,1,0,0,0,0,0]
["5-fluoro-N,2-dimethyl-N'-((6-(pyridin-3-yl)imidazo(1,2-a)pyridin-3-yl)methylene)benzenesulfonohydrazide","5-fluoro-N,2-dimethyl-N'-((6-(pyridin-3-yl)imidazo(1,2-a)pyridin-3-yl)methylene)benzenesulfonohydrazide","C000593995",0,0,2,0,0,0,0]
["5-geranyloxy-7-methoxycoumarin","5-geranyloxy-7-methoxycoumarin","C442483",0,0,0,0,2,0,0]
["5-hydroxy-6,7,8,3',4'-pentamethoxyflavone","5-hydroxy-6,7,8,3',4'-pentamethoxyflavone","C553978",0,1,2,0,4,0,0]
["5-hydroxy-8-methoxy-2-phenyl-7-(4-(pyrrolidin-1-yl)butoxy)4H-chromen-4-one","5-hydroxy-8-methoxy-2-phenyl-7-(4-(pyrrolidin-1-yl)butoxy)4H-chromen-4-one","C561826",0,0,2,0,5,0,0]
["5-hydroxymethyluracil","5-hydroxymethyluracil","C008055",6,0,0,0,2,0,0]
["5-ketogluconic acid","5-ketogluconic acid","C093583",6,0,0,0,0,0,0]
["5-methoxyanthranilic acid","5-methoxyanthranilic acid","C582649",2,0,0,0,0,0,0]
["5-methoxypsoralen","5-methoxypsoralen","C022909",0,0,4,1,6,5,0]
["5-methyltetrahydrofolate pentaglutamate","5-methyltetrahydrofolate pentaglutamate","C403520",2,0,0,0,0,0,0]
["5-nitro-5'-hydroxyindirubin-3'-oxime","5-nitro-5'-hydroxyindirubin-3'-oxime","C000609730",0,0,0,0,1,0,0]
["5-O-feruloylarabinose","5-O-feruloylarabinose","C072516",2,0,0,0,0,0,0]
["5-phenyl-15-(3-hydroxyphenyl)porphyrin","5-phenyl-15-(3-hydroxyphenyl)porphyrin","C540818",0,0,0,0,1,0,0]
["5-ylidene-4- aminothiazol-2(5H)-one","5-ylidene-4- aminothiazol-2(5H)-one","C000607212",0,0,2,0,0,0,0]
["6-(1-(2,6-difluorophenyl)ethyl)-2-(dimethylamino)-5-methylpyrimidin-4(3H)-one","6-(1-(2,6-difluorophenyl)ethyl)-2-(dimethylamino)-5-methylpyrimidin-4(3H)-one","C506288",0,0,2,0,0,0,0]
["6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-quinoxalinedione","6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-quinoxalinedione","C086162",2,0,0,0,0,0,0]
["6-(2-hydroxyimino-2-(4-methoxyphenyl)ethoxy)-2-phenyl-4H-1-benzopyran-4-one","6-(2-hydroxyimino-2-(4-methoxyphenyl)ethoxy)-2-phenyl-4H-1-benzopyran-4-one","C000608830",0,0,2,0,2,0,0]
["6-(3-hydroxybenzylamino)-9-tetrahydrofuran-2-ylpurine","6-(3-hydroxybenzylamino)-9-tetrahydrofuran-2-ylpurine","C540741",2,0,0,0,0,0,0]
["6-(4-chlorobenzyl)-1H-spiro(imidazo(1,5-c)thiazole-3,3'-indoline)-2',5,7(6H,7aH)-trione","6-(4-chlorobenzyl)-1H-spiro(imidazo(1,5-c)thiazole-3,3'-indoline)-2',5,7(6H,7aH)-trione","C000594641",0,0,2,0,6,0,0]
["6-(9-(diethylamino)-5-oxo-5 H-benzo(alpha)phenoxazin-2-yloxy)hex-2-enyl acetate","6-(9-(diethylamino)-5-oxo-5 H-benzo(alpha)phenoxazin-2-yloxy)hex-2-enyl acetate","C541734",2,0,0,0,0,0,0]
["6(hydroxymethyl)-1,4-anthracenedione","6(hydroxymethyl)-1,4-anthracenedione","C530630",0,0,1,0,0,0,0]
["6,6',7,7'-tetrahydroxy-3,3'-dimethyl-5,5'-bis(4-methylphenethyl)-2,2'-binaphthyl-1,1',4,4'-tetraone","6,6',7,7'-tetrahydroxy-3,3'-dimethyl-5,5'-bis(4-methylphenethyl)-2,2'-binaphthyl-1,1',4,4'-tetraone","C554508",0,0,2,0,1,0,0]
["6,7,4'-trihydroxyisoflavone","6,7,4'-trihydroxyisoflavone","C502164",0,0,7,1,2,0,0]
["6,7-dihydroxy-3-(-prop-1-enyl)isobenzofuran-1(3H)-one","6,7-dihydroxy-3-(-prop-1-enyl)isobenzofuran-1(3H)-one","C530897",0,0,2,0,0,0,0]
["6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one","6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one","C438505",0,0,0,0,1,0,0]
["6-acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo(d)oxazol-2(3H)-one","6-acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo(d)oxazol-2(3H)-one","C557789",0,1,0,0,2,0,0]
["6-acrylic phenethyl ester-2-pyranone","6-acrylic phenethyl ester-2-pyranone","C000599524",0,0,0,0,1,0,0]
["6-aminophenanthridine","6-aminophenanthridine","C549408",0,0,0,0,0,1,0]
["6-bromoacetyl-2-dimethylaminonaphthalene","6-bromoacetyl-2-dimethylaminonaphthalene","C122155",0,0,0,0,1,1,0]
["6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide","6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide","C550547",0,0,8,0,3,0,0]
["6-demethyl-9-(N,N-dimethylglycylamido)-6-deoxytetracycline","6-demethyl-9-(N,N-dimethylglycylamido)-6-deoxytetracycline","C085306",2,0,0,0,0,1,0]
["6-ethyl-6-(4-((phenylthio)methyl)phenyl)-6,7-dihydrobenzo(b)pyrrolo(1,2-d)(1,4)oxazepin-7-one","6-ethyl-6-(4-((phenylthio)methyl)phenyl)-6,7-dihydrobenzo(b)pyrrolo(1,2-d)(1,4)oxazepin-7-one","C558526",0,0,2,0,2,0,0]
["6-fluoropyridoxal phosphate","6-fluoropyridoxal phosphate","C044386",2,0,0,0,0,0,0]
["6-hydrazinopyridine-3-carboxylic acid","6-hydrazinopyridine-3-carboxylic acid","C120392",0,0,0,0,2,0,0]
["6-hydroxy-9-methoxy-11H-indeno(1,2-c)quinolin-11-one O-2-(pyrrolidin-1-yl)ethyl oxime","6-hydroxy-9-methoxy-11H-indeno(1,2-c)quinolin-11-one O-2-(pyrrolidin-1-yl)ethyl oxime","C552106",0,0,0,0,2,0,0]
["6-iodopenicillanic acid","6-iodopenicillanic acid","C031528",4,0,0,0,0,0,0]
["6-ketocholestanol","6-ketocholestanol","C063833",2,0,0,0,0,0,0]
["6-methoxy-8-(3-diethylaminopropylamino)quinoline","6-methoxy-8-(3-diethylaminopropylamino)quinoline","C057521",0,2,0,0,0,0,0]
["6-monoamino-6-monodeoxy-beta-cyclodextrin","6-monoamino-6-monodeoxy-beta-cyclodextrin","C000596609",2,0,0,0,0,0,0]
["6-O-angeloylprenolin","6-O-angeloylprenolin","C509025",0,0,2,0,0,0,0]
["6-paradol","6-paradol","C421614",0,0,4,0,6,0,0]
["6-sulfogalactopyranoyl-1-4-N-acetyl-6-sulfoglucosamine","6-sulfogalactopyranoyl-1-4-N-acetyl-6-sulfoglucosamine","C502748",0,0,0,0,2,0,0]
["6-thio-(5N,6S)-(4-(N'-dansylamino)butyliminomethylidene)nojirimycin","6-thio-(5N,6S)-(4-(N'-dansylamino)butyliminomethylidene)nojirimycin","C557857",2,0,0,0,0,0,0]
["7-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-5-(3-piperidinyl)-1,4-dihydro-2H-pyrido(2,3-d)(1,3)oxazin-2-one","7-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-5-(3-piperidinyl)-1,4-dihydro-2H-pyrido(2,3-d)(1,3)oxazin-2-one","C502972",0,0,4,0,2,0,0]
["7-(4-(2,2-bisphosphonoethyl)piperazin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid","7-(4-(2,2-bisphosphonoethyl)piperazin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid","C455825",2,0,0,0,0,0,0]
["7-(N-benzyl-N-methylamino)-2-oxo-2H-chromene-3-carboxylic acid","7-(N-benzyl-N-methylamino)-2-oxo-2H-chromene-3-carboxylic acid","C588295",0,0,2,0,0,0,0]
["7,3'-dihydroxy-4'-methoxyisoflavone","7,3'-dihydroxy-4'-methoxyisoflavone","C121707",2,0,40,1,37,0,0]
["7,8,4'-trihydroxyisoflavone","7,8,4'-trihydroxyisoflavone","C502165",0,0,1,1,0,0,0]
["7,8-dihydroneopterin","7,8-dihydroneopterin","C000976",4,0,0,0,20,0,0]
["7,9-difluoro-5-(4-(2-piperidin-1-ylethoxy)phenyl)-5H-6-oxachrysen-2-ol","7,9-difluoro-5-(4-(2-piperidin-1-ylethoxy)phenyl)-5H-6-oxachrysen-2-ol","C508986",0,0,2,0,0,0,0]
["7-amino-4-trifluoromethylcoumarin","7-amino-4-trifluoromethylcoumarin","C055467",2,0,0,0,0,0,0]
["7-bromoindirubin-3'-oxime","7-bromoindirubin-3'-oxime","C514974",0,1,0,0,4,0,0]
["7-chloro-2,3-dihydro-1-(2-methylbenzoyl)-4(1H)-quinolinone 4-oxime-O-sulfonic acid","7-chloro-2,3-dihydro-1-(2-methylbenzoyl)-4(1H)-quinolinone 4-oxime-O-sulfonic acid","C079648",2,0,0,0,0,0,0]
["7-deazapurine","7-deazapurine","C512929",2,0,4,0,0,0,0]
["7-ethyl-7-hydroxy-10H-1,3-Dioxolo(4,5-g)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-8,11(7H,12H)-dione","7-ethyl-7-hydroxy-10H-1,3-Dioxolo(4,5-g)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-8,11(7H,12H)-dione","C578515",0,0,2,0,4,0,0]
["7-hydroxy-2-(4-hydroxystyryl)-1-benzopyrylium","7-hydroxy-2-(4-hydroxystyryl)-1-benzopyrylium","C576709",2,0,0,0,0,0,0]
["7-hydroxymethotrexate","7-hydroxymethotrexate","C011864",10,0,0,0,0,0,0]
["7-ketolithocholic acid","7-ketolithocholic acid","C023020",4,0,0,0,0,0,0]
["7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine","7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine","C576403",0,1,2,0,4,0,0]
["7-methyljuglone","7-methyljuglone","C517013",0,0,2,0,6,0,0]
["7-nitrobenzoxadiazole","7-nitrobenzoxadiazole","C542965",2,0,0,0,0,0,0]
["7-phenyl-6H-(1,2,5)oxadiazolo(3,4-e)indole 3-oxide","7-phenyl-6H-(1,2,5)oxadiazolo(3,4-e)indole 3-oxide","C559941",0,0,2,0,1,0,0]
["8-(2-(2-pentyl-cyclopropylmethyl)cyclopropyl)octanoic acid","8-(2-(2-pentyl-cyclopropylmethyl)cyclopropyl)octanoic acid","C506022",0,0,0,0,2,0,0]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C7364,B7364)","v":"8-(3-dimethylaminopropionyl)-1,6-benzodioxocane"},"8-(3-dimethylaminopropionyl)-1,6-benzodioxocane","C097945",0,2,0,0,0,0,0]
["8,11-dihydroxy-6-((2-(dimethylamino)ethyl)amino)-7H-benzo(e)perimidin-7-one","8,11-dihydroxy-6-((2-(dimethylamino)ethyl)amino)-7H-benzo(e)perimidin-7-one","C121667",0,0,0,0,2,0,0]
["8,9-anhydroerythromycin A 6,9-hemiketal","8,9-anhydroerythromycin A 6,9-hemiketal","C093673",0,0,2,0,0,0,0]
["8-aza-7-deazaadenine","8-aza-7-deazaadenine","C414764",4,0,2,0,0,0,0]
["8-cetylberberine","8-cetylberberine","C000604411",0,0,2,0,2,0,0]
["8-gingerol","8-gingerol","C534464",0,0,2,0,0,0,0]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C7428,B7428)","v":"8-hydroxy-7-(4-sulfo-1-naphthylazo)-5-quinoline sulfonic acid"},"8-hydroxy-7-(4-sulfo-1-naphthylazo)-5-quinoline sulfonic acid","C527682",4,0,0,0,0,0,0]
["8-methyl-2-(morpholine-4-yl)-7-(pyridine-3-methoxy)-4H-1,3-benzoxacine-4-one","8-methyl-2-(morpholine-4-yl)-7-(pyridine-3-methoxy)-4H-1,3-benzoxacine-4-one","C000594950",0,0,0,0,2,0,0]
["8-methylpentadecanoic acid","8-methylpentadecanoic acid","C098700",4,0,0,0,0,0,0]
["8-oxo-O(6)-benzylguanine","8-oxo-O(6)-benzylguanine","C110997",2,0,0,0,0,0,0]
["9-((3-chloro)phenylamine)-2-(3-(diethylamine)propylamine)thiazolo(5,4-b)quinoline","9-((3-chloro)phenylamine)-2-(3-(diethylamine)propylamine)thiazolo(5,4-b)quinoline","C560931",0,0,2,0,0,0,0]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C7492,B7492)","v":"9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine"},"9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine","C050127",2,1,0,0,0,0,0]
["9-(dimethylaminoethoxy)ellipticine","9-(dimethylaminoethoxy)ellipticine","C529584",0,0,0,0,2,0,0]
["9,10-dimethoxy-3,3-dimethyl-7,7a,13,13atetrahydro-3H-chromeno(3,4-b)pyrano(2,3-h)chromen-7-ol","9,10-dimethoxy-3,3-dimethyl-7,7a,13,13atetrahydro-3H-chromeno(3,4-b)pyrano(2,3-h)chromen-7-ol","C569212",0,0,0,0,2,0,0]
["9-amino-6-chloro-2-methoxyacridine","9-amino-6-chloro-2-methoxyacridine","C010847",2,0,2,0,0,0,0]
["9-bromo-5-(4,5-dimethoxy-1,3-dihydroisobenzofuran-1-yl)-4-methoxy-6-methyl-5,6,7,8-tetrahydro-(1,3)-dioxolo(4,5-g)isoquinoline","9-bromo-5-(4,5-dimethoxy-1,3-dihydroisobenzofuran-1-yl)-4-methoxy-6-methyl-5,6,7,8-tetrahydro-(1,3)-dioxolo(4,5-g)isoquinoline","C550328",0,0,0,0,3,0,0]
["9-deoxo-12-deoxy-9,12-epoxyerythromycin","9-deoxo-12-deoxy-9,12-epoxyerythromycin","C069957",2,0,0,0,0,0,0]
["9-ethyladenine","9-ethyladenine","C001172",6,0,0,0,0,0,0]
["9-fluorenylmethoxycarbonyl","9-fluorenylmethoxycarbonyl","C496789",8,0,2,0,0,0,0]
["9-hydroxystearic acid","9-hydroxystearic acid","C070375",0,0,11,0,3,0,0]
["9-methylguanine","9-methylguanine","C116701",2,0,0,0,0,0,0]
["9-oxononanoyl cholesterol","9-oxononanoyl cholesterol","C114702",0,0,2,0,0,0,0]
["A 315675","A 315675","C456059",0,0,0,0,0,1,0]
["A-674563","A-674563","C000619514",0,0,8,0,4,0,0]
["AA9 compound","AA9 compound","C000612900",0,0,2,0,0,0,0]
["abiraterone","abiraterone","C089740",0,0,14,0,4,0,0]
["aburatubolactam C","aburatubolactam C","C112446",0,0,0,0,2,0,0]
["Ac-cel compound","Ac-cel compound","C585532",0,0,0,0,2,0,0]
["acemannan","acemannan","C058414",4,2,14,0,2,0,0]
["acetaminophen, codeine drug combination","acetaminophen, codeine drug combination","C526278",0,1,0,0,0,0,0]
["Acetohexamide","Acetohexamide","D000092",6,0,0,0,0,0,0]
["acetosyringone","acetosyringone","C051667",8,0,0,0,0,1,0]
["Acetylene","Acetylene","D000114",46,2,9,0,12,0,0]
["acetyltanshinone IIA","acetyltanshinone IIA","C552419",0,0,4,0,4,0,0]
["acetyltrimethylsilane","acetyltrimethylsilane","C477044",6,0,0,0,0,0,0]
["acid citrate dextrose","acid citrate dextrose","C002113",24,0,0,0,0,0,0]
["acid red 337","acid red 337","C568618",2,0,0,0,0,0,0]
["aclacinomycins","aclacinomycins","C011157",4,0,3,0,5,1,0]
["acridan","acridan","C011633",2,0,0,0,0,0,0]
["actein","actein","C096064",0,0,14,0,8,0,0]
["acutolysin D, Agkistrodon","acutolysin D, Agkistrodon","C488502",2,0,0,0,0,0,0]
["Adapalene, Benzoyl Peroxide Drug Combination","Adapalene, Benzoyl Peroxide Drug Combination","D000068801",0,2,0,0,0,0,0]
["adefovir dipivoxil","adefovir dipivoxil","C106812",2,0,2,0,0,1,0]
["AdipoRon","AdipoRon","C585113",0,0,2,0,2,0,0]
["ADT-094","ADT-094","C000609868",0,0,1,0,1,0,0]
["AEOL 10150","AEOL 10150","C472668",0,0,2,2,6,0,0]
["AF-HF001","AF-HF001","C000611870",0,0,0,0,2,0,0]
["AG 556","AG 556","C098981",0,1,0,0,2,0,0]
["agelastatin A","agelastatin A","C464968",0,0,4,0,0,0,0]
["agkistin","agkistin","C411880",0,0,0,2,2,0,0]
["agrocinopin B","agrocinopin B","C109409",0,0,0,0,0,1,0]
["aildenafil","aildenafil","C520604",2,0,0,0,0,0,0]
["ajudazol B","ajudazol B","C485091",0,0,0,0,0,1,0]
["AL 8810 ethylamide","AL 8810 ethylamide","C518977",0,0,0,0,2,0,0]
["alclometasone dipropionate","alclometasone dipropionate","C021137",0,2,0,0,0,0,0]
["Alexa fluor 546","Alexa fluor 546","C481052",2,0,2,0,2,0,0]
["alisol B 23-acetate","alisol B 23-acetate","C526957",0,0,4,0,4,0,0]
["alkamin","alkamin","C539372",0,0,2,0,0,0,0]
["allergen Blo t 5","allergen Blo t 5","C094701",2,0,0,0,0,0,0]
["allobarbital","allobarbital","C084828",2,0,0,0,2,0,0]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C8068,B8068)","v":"allyl formate"},"allyl formate","C034499",0,2,0,0,0,0,0]
["allylthiourea","allylthiourea","C009842",4,0,0,0,2,0,0]
["Aloe vera gel","Aloe vera gel","C586178",4,0,0,0,0,0,0]
["alpha-(4-methoxyphenyl)-2',3,4,4'-tetramethoxychalcone","alpha-(4-methoxyphenyl)-2',3,4,4'-tetramethoxychalcone","C000608611",0,0,0,0,1,0,0]
["alpha-bergamotene","alpha-bergamotene","C423904",0,0,0,0,0,1,0]
["alpha-conotoxin Vc1.1","alpha-conotoxin Vc1.1","C507383",2,0,0,0,0,0,0]
["alpha-glucoheptonic acid","alpha-glucoheptonic acid","C007852",0,0,0,0,1,0,0]
["alpha-ionone","alpha-ionone","C011879",6,0,0,0,0,0,0]
["alpha-keto-delta-(NG,NG-dimethylguanidino)valeric acid","alpha-keto-delta-(NG,NG-dimethylguanidino)valeric acid","C569758",2,0,0,0,0,0,0]
["alpha-methylhydrocinnamic acid","alpha-methylhydrocinnamic acid","C470568",0,0,4,0,4,0,0]
["alpha-tenoyltrifluoroacetone","alpha-tenoyltrifluoroacetone","C510738",2,0,0,0,0,0,0]
["alpha-tocopherol phosphate","alpha-tocopherol phosphate","C012552",0,0,2,0,13,0,0]
["altersolanol A","altersolanol A","C058812",0,0,2,0,4,0,0]
["aluminoborate cement","aluminoborate cement","C036916",0,1,0,0,0,0,0]
["aluminum hydroxide, magnesium hydroxide, simethicone drug combination","aluminum hydroxide, magnesium hydroxide, simethicone drug combination","C008570",8,0,0,0,0,0,0]
["aluminum phosphide","aluminum phosphide","C001864",0,2,0,0,3,0,0]
["ALVAC-HIV vCP1452","ALVAC-HIV vCP1452","C468116",0,0,1,0,0,0,0]
["amariin","amariin","C581165",0,0,0,0,2,0,0]
["Amberlite IR-120","Amberlite IR-120","C025242",2,0,0,0,0,0,0]
["Ambroxol","Ambroxol","D000551",33,0,0,0,5,0,0]
["amidoxanthone","amidoxanthone","C000611507",0,0,2,0,2,0,0]
["aminobenzanthrone","aminobenzanthrone","C516993",2,0,0,0,0,0,0]
["aminoindanol","aminoindanol","C116915",2,0,2,0,0,0,0]
["aminopropylsilane","aminopropylsilane","C024702",2,0,0,0,0,0,0]
["Amitriptyline","Amitriptyline","D000639",87,8,8,0,24,0,0]
["amminedichloro(cyclohexylamine)platinum(II)","amminedichloro(cyclohexylamine)platinum(II)","C097758",0,0,4,0,1,0,0]
["ammonium carbonate","ammonium carbonate","C040502",6,0,0,0,0,0,0]
["ammophos","ammophos","C049682",2,0,0,0,0,0,0]
["ampelopsin","ampelopsin","C106407",2,0,24,1,31,0,0]
["amphotericin B, deoxycholate drug combination","amphotericin B, deoxycholate drug combination","C059765",2,0,2,0,1,0,0]
["amrubicinol","amrubicinol","C116173",0,3,0,0,5,0,0]
["amylopectin sulfate","amylopectin sulfate","C000153",0,0,0,2,0,0,0]
["anabaseine","anabaseine","C091713",2,0,0,0,0,0,0]
["AndoSan","AndoSan","C579023",0,0,2,0,0,0,0]
["androstane","androstane","C033936",0,0,6,0,4,0,0]
["angelylalkannin","angelylalkannin","C580562",0,0,2,0,2,0,0]
["anisodamine","anisodamine","C003922",7,3,6,0,5,0,0]
["Anisomycin","Anisomycin","D000841",0,0,14,0,54,0,0]
["antcin K","antcin K","C000602429",0,0,0,0,2,0,0]
["Anthralin","Anthralin","D000875",12,1,14,0,8,0,0]
["antibiotic 6108B","antibiotic 6108B","C066090",2,0,0,0,0,0,0]
["antigen Dlx-2","antigen Dlx-2","C092261",0,1,0,0,1,0,0]
["Antipyrine","Antipyrine","D000983",92,19,15,0,162,0,0]
["Apamin","Apamin","D001030",14,0,6,0,2,0,0]
["apigenin-7-O-glucuronide","apigenin-7-O-glucuronide","C456097",2,0,0,0,0,0,0]
["apigeninidin","apigeninidin","C104027",4,0,0,0,0,1,0]
["apoptolidin","apoptolidin","C114125",0,0,2,0,19,0,0]
["apricoxib","apricoxib","C514354",0,0,4,1,4,0,0]
["aquacobalamin","aquacobalamin","C043960",8,0,0,0,0,0,0]
["arabinobiose","arabinobiose","C434937",2,0,0,0,0,0,0]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C8644,B8644)","v":"arachidic acid"},"arachidic acid","C094477",2,0,0,0,0,0,0]
["arbekacin","arbekacin","C031986",0,2,0,0,0,0,0]
["Arecoline","Arecoline","D001115",6,3,23,0,22,1,0]
["argentatin A","argentatin A","C465304",0,0,4,0,0,0,0]
["aristolochic acid II","aristolochic acid II","C042310",4,0,0,0,0,2,0]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C8708,B8708)","v":"ARM resin"},"ARM resin","C090889",2,0,0,0,0,0,0]
["arpadol","arpadol","C000618350",0,0,2,0,0,0,0]
["arsenazo I","arsenazo I","C035803",2,0,0,0,0,0,0]
["arsenosugar","arsenosugar","C449161",4,0,0,0,2,0,0]
["artemetin","artemetin","C054132",0,0,0,0,2,0,0]
["AS 2-006A","AS 2-006A","C406665",0,0,0,0,2,0,0]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C8772,B8772)","v":"AS2553627"},"AS2553627","C000617792",0,0,2,0,0,0,0]
["ascorbigen","ascorbigen","C053152",2,0,2,0,0,0,0]
["asoprisnil","asoprisnil","C488516",0,0,10,0,10,0,0]
["asperfuranone","asperfuranone","C552682",0,0,2,0,2,0,0]
["Asta Z 7557","Asta Z 7557","C037933",4,1,2,0,2,0,0]
["astragalin heptaacetate","astragalin heptaacetate","C562213",0,0,2,0,2,0,0]
["asulam","asulam","C010036",6,0,0,0,0,0,0]
["atranol","atranol","C493895",2,0,1,0,0,0,0]
["Atrazine","Atrazine","D001280",152,5,27,1,30,1,0]
["aureusidin","aureusidin","C416232",2,0,0,0,0,0,0]
["aurovertin B","aurovertin B","C034402",0,0,2,0,2,0,0]
["avermectin","avermectin","C019264",20,0,6,0,4,2,0]
["AWD 131-138","AWD 131-138","C116306",2,0,0,0,0,0,0]
["Azacosterol","Azacosterol","D001373",2,0,0,0,0,0,0]
["azasetron","azasetron","C070671",0,0,2,0,4,0,0]
["AZD2014","AZD2014","C585537",0,0,9,0,8,0,0]
["AZD2461","AZD2461","C000609611",0,0,2,0,2,0,0]
["azilsartan","azilsartan","C521273",0,0,0,0,2,0,0]
["aziridine","aziridine","C033132",17,0,7,0,2,0,0]
["azulene","azulene","C005525",2,1,1,0,4,0,0]
["B19 monocarbonyl curcumin","B19 monocarbonyl curcumin","C587237",0,0,0,0,2,0,0]
["bacimethrin","bacimethrin","C054356",0,0,0,0,0,1,0]
["bafilomycin B1","bafilomycin B1","C052501",12,0,0,0,4,0,0]
["bamboo salt","bamboo salt","C000605706",0,0,0,0,2,0,0]
["bambuterol","bambuterol","C047766",4,0,0,0,0,0,0]
["barium hydroxyapatite","barium hydroxyapatite","C041297",0,0,1,0,0,0,0]
["basic yellow 28","basic yellow 28","C516484",8,0,0,0,0,0,0]
["bathocuproine","bathocuproine","C002478",2,0,0,0,0,0,0]
["Bay 12-9566","Bay 12-9566","C113281",0,0,0,3,0,0,0]
["bazedoxifene","bazedoxifene","C447119",2,8,14,0,8,0,0]
["Bc-4 active principle","Bc-4 active principle","C078192",0,0,0,0,2,0,0]
["bedaquiline","bedaquiline","C493870",4,0,4,1,0,0,0]
["beidellite","beidellite","C010863",2,0,0,0,0,0,0]
["bendazac lysine","bendazac lysine","C036067",0,1,0,0,0,0,0]
["benphothiamine","benphothiamine","C013835",0,0,11,0,19,0,0]
["benz(c)acridine","benz(c)acridine","C035985",4,0,0,0,4,0,0]
["benzamidoxime","benzamidoxime","C053561",2,0,2,0,2,0,0]
["benzenesulfonamide","benzenesulfonamide","C038198",7,0,24,0,8,0,0]
["benzo(a)pyrene 4,5-epoxide","benzo(a)pyrene 4,5-epoxide","C006707",4,0,0,0,0,0,0]
["benzo(b)acronycine","benzo(b)acronycine","C504489",0,0,4,0,0,0,0]
["benzo(d)oxazol-2(3H)-one","benzo(d)oxazol-2(3H)-one","C000612781",0,0,2,0,0,0,0]
["benzo-lipoxin A4","benzo-lipoxin A4","C562252",0,0,0,0,2,0,0]
["benzothiazoline","benzothiazoline","C058836",0,0,0,0,1,0,0]
["benzoxazolone","benzoxazolone","C017057",4,0,4,0,2,0,0]
["Benzyl Alcohol","Benzyl Alcohol","D019905",22,2,0,0,7,0,0]
["Benzyl Viologen","Benzyl Viologen","D001594",4,0,0,0,0,0,0]
["benzylhydrazine","benzylhydrazine","C006730",0,0,2,0,2,0,0]
["bepafant","bepafant","C063964",0,2,0,0,4,0,0]
["berupipam","berupipam","C096844",2,0,0,0,0,0,0]
["beta-2-himachalen-6-ol","beta-2-himachalen-6-ol","C000617228",0,0,0,0,6,0,0]
["beta-D-galactopyranosylmethyl-4-nitrophenyltriazene","beta-D-galactopyranosylmethyl-4-nitrophenyltriazene","C018547",2,0,0,0,0,0,0]
["beta-glucono-1,5-lactone","beta-glucono-1,5-lactone","C010730",30,0,0,0,0,0,0]
["beta-macrocarpene","beta-macrocarpene","C531190",2,0,0,0,0,0,0]
["beta-Naphthoflavone","beta-Naphthoflavone","D019324",2,6,7,0,6,1,0]
["Betaxolol","Betaxolol","D015784",12,0,0,0,1,0,0]
["betulin","betulin","C002503",2,0,46,0,51,0,0]
["BFD-22","BFD-22","C000609140",0,0,2,0,2,0,0]
["BIBF 1000","BIBF 1000","C509119",0,0,0,0,4,0,0]
["bicozamycin","bicozamycin","C024504",0,0,0,0,0,2,0]
["biflorin","biflorin","C522781",0,0,0,0,2,0,0]
["bilirubin diglucuronide","bilirubin diglucuronide","C019270",2,0,0,0,0,0,0]
["bimosiamose","bimosiamose","C496819",2,0,2,0,0,0,0]
["binol-bisboronic acid","binol-bisboronic acid","C499491",2,0,0,0,0,0,0]
["biosporin","biosporin","C091592",2,0,0,0,0,0,0]
["birnessite","birnessite","C505018",38,0,0,0,0,0,0]
["bis(2-(1-methyl-1H-imidazolyl)phenyl)phosphate","bis(2-(1-methyl-1H-imidazolyl)phenyl)phosphate","C527956",4,0,0,0,0,0,0]
["bis(2,3-dibromosalicyl)fumarate","bis(2,3-dibromosalicyl)fumarate","C050588",2,0,2,0,2,0,0]
["bis(2-aminobutanol)dichloroplatinum(II)","bis(2-aminobutanol)dichloroplatinum(II)","C516534",2,0,0,0,0,0,0]
["bis(3,5-dimethyl-5-hydroxymethyl-2-oxomorpholin-3-yl)","bis(3,5-dimethyl-5-hydroxymethyl-2-oxomorpholin-3-yl)","C047248",0,2,0,0,0,0,0]
["bis(4,7-dimethyl-1,10-phenanthroline)sulfatooxovanadium(IV)","bis(4,7-dimethyl-1,10-phenanthroline)sulfatooxovanadium(IV)","C411475",0,0,0,0,4,0,0]
["bis(8(4-(4-amino-1-methyl-1H-pyrrole-2-carbonylamino)-1-methyl-1H-pyrrole-2-carbonylamino)naphthalene-1,5-disulfonic acid) tetrasodium salt","bis(8(4-(4-amino-1-methyl-1H-pyrrole-2-carbonylamino)-1-methyl-1H-pyrrole-2-carbonylamino)naphthalene-1,5-disulfonic acid) tetrasodium salt","C115096",0,0,0,1,0,0,0]
["bis(diazo)benzidine","bis(diazo)benzidine","C006770",2,0,0,0,0,0,0]
["bis(isopropyloxymethylcarbonyl) 9-(2-phosphonomethoxypropyl)adenine","bis(isopropyloxymethylcarbonyl) 9-(2-phosphonomethoxypropyl)adenine","C111774",2,0,0,0,0,0,0]
["bis(tert-butylphenyl) phosphate","bis(tert-butylphenyl) phosphate","C075901",0,0,2,0,0,0,0]
["bisantrene-tetrachloroplatinum dianion complex","bisantrene-tetrachloroplatinum dianion complex","C075424",2,0,0,0,0,0,0]
["Bisfil","Bisfil","C078905",2,0,0,0,0,0,0]
["bisnafide","bisnafide","C084899",4,0,0,0,0,0,0]
["bisperoxo(1,10-phenanthroline)oxovanadate(1-)","bisperoxo(1,10-phenanthroline)oxovanadate(1-)","C102120",0,0,0,0,6,0,0]
["bisphosphatidic acid","bisphosphatidic acid","C021632",2,0,0,0,0,0,0]
["Biuret","Biuret","D001737",4,0,0,0,0,0,0]
["BK10040","BK10040","C000592788",0,0,0,0,2,0,0]
["Blood Glucose","Blood Glucose","D001786",923,50,85,15,119,0,0]
["BMS188797","BMS188797","C436443",0,0,0,0,1,0,0]
["BMS-871","BMS-871","C000604995",0,0,2,0,0,0,0]
["BN 52063","BN 52063","C050422",0,1,0,0,0,0,0]
["boesenbergin A","boesenbergin A","C581718",0,0,0,0,2,0,0]
["Bonolive","Bonolive","C000601880",0,0,0,0,2,0,0]
["boron nitride","boron nitride","C017282",4,0,14,0,3,0,0]
["boseongazepine C","boseongazepine C","C000596315",0,0,2,0,0,0,0]
["BPC11 compound","BPC11 compound","C000610764",0,0,0,0,2,0,0]
["brassinin","brassinin","C089020",2,0,10,0,6,0,0]
["breviscapine","breviscapine","C061097",4,0,4,1,20,0,0]
["brivaracetam","brivaracetam","C482793",0,0,2,0,2,0,0]
["Bromcresol Green","Bromcresol Green","D001961",28,0,0,0,0,0,0]
["bromo(2,9-(2,5,8-triaza-5-(N-anthracene-9-methylamino)ethyl)-(9)-1,10-phenanthrolinophane)zinc(II)","bromo(2,9-(2,5,8-triaza-5-(N-anthracene-9-methylamino)ethyl)-(9)-1,10-phenanthrolinophane)zinc(II)","C511192",2,0,0,0,0,0,0]
["bromodichloromethane","bromodichloromethane","C025191",6,0,2,0,0,0,0]
["bromopyruvate","bromopyruvate","C017092",22,7,40,3,74,0,0]
["bronopol","bronopol","C006827",2,1,0,0,0,0,0]
["bryostatin 16","bryostatin 16","C102705",0,0,2,0,0,0,0]
["BU 224","BU 224","C105826",0,0,0,0,2,0,0]
["budlein A","budlein A","C520233",0,0,4,0,2,0,0]
["bullatine A","bullatine A","C587049",0,0,0,0,2,0,0]
["buriti oil","buriti oil","C548591",2,0,0,0,0,0,0]
["Butaclamol","Butaclamol","D002069",2,0,0,0,0,0,0]
["butrin","butrin","C049386",0,0,2,0,2,0,0]
["butyl fructofuranoside","butyl fructofuranoside","C098581",0,0,2,0,0,0,0]
["butyramide","butyramide","C006866",2,0,1,0,0,0,0]
["butyroyloxymethyl 4-phenylbutyrate","butyroyloxymethyl 4-phenylbutyrate","C523320",0,0,2,0,0,0,0]
["BY 831-78","BY 831-78","C061000",2,0,0,0,0,0,0]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C10052,B10052)","v":"C 1368"},"C 1368","C550259",0,0,2,0,0,0,0]
["C.I. Acid Violet 109","C.I. Acid Violet 109","C000606670",2,0,0,0,0,0,0]
["C.I. Reactive Red 228","C.I. Reactive Red 228","C587837",2,0,0,0,0,0,0]
["C4a-hydroperoxyflavin","C4a-hydroperoxyflavin","C531259",2,0,0,0,0,0,0]
["cabozantinib","cabozantinib","C558660",4,1,36,7,16,0,0]
["cafestol","cafestol","C053400",2,0,6,0,6,0,0]
["caffeoylmalic acid","caffeoylmalic acid","C099798",0,0,0,0,2,0,0]
["calanquinone A","calanquinone A","C530567",0,0,2,0,0,0,0]
["Calcitriol","Calcitriol","D002117",91,22,517,24,503,9,0]
["calcium borate","calcium borate","C031316",0,0,0,1,0,0,0]
["Calcium Fluoride","Calcium Fluoride","D002124",69,0,0,0,1,0,0]
["calcium phosphate, dibasic, dihydrate","calcium phosphate, dibasic, dihydrate","C494366",68,0,21,0,2,0,0]
["calcium propionate","calcium propionate","C514136",4,0,0,0,0,0,0]
["calix(4)arene","calix(4)arene","C121325",44,0,10,0,2,0,0]
["calix(6)arene","calix(6)arene","C476540",18,0,4,0,2,0,0]
["calystegine B(2)","calystegine B(2)","C095613",2,0,0,0,0,0,0]
["camphorataimide B","camphorataimide B","C574869",0,0,2,0,2,0,0]
["canadine","canadine","C004645",0,0,2,0,2,0,0]
["canertinib dihydrochloride","canertinib dihydrochloride","C072383",0,0,0,0,2,0,0]
["Canrenoic Acid","Canrenoic Acid","D002191",0,0,2,0,0,0,0]
["capilliposide C","capilliposide C","C511098",0,0,4,0,3,0,0]
["caracurine V","caracurine V","C041536",0,0,0,0,0,1,0]
["carbendazim","carbendazim","C006698",42,3,4,0,16,3,0]
["carboapatite","carboapatite","C030782",31,0,17,0,0,0,0]
["Carbonated Water","Carbonated Water","D061545",0,0,1,0,0,0,0]
["carbopol 940","carbopol 940","C006903",490,8,28,0,10,0,0]
["Carboxin","Carboxin","D002261",0,0,0,0,0,1,0]
["carboxymethyl-chitosan","carboxymethyl-chitosan","C514968",70,0,24,1,22,0,0]
["carboxymethyl-gamma-cyclodextrin","carboxymethyl-gamma-cyclodextrin","C092583",2,0,0,0,0,0,0]
["Carolina rinse solution","Carolina rinse solution","C070887",2,0,0,0,0,0,0]
["caryophyllene","caryophyllene","C024714",4,0,11,1,4,0,0]
["casiopeina II-glycine","casiopeina II-glycine","C505569",0,0,6,0,5,0,0]
["catechin gallate","catechin gallate","C417939",2,0,6,0,4,0,0]
["catharinine","catharinine","C058716",2,0,0,0,0,0,0]
["cavity shield","cavity shield","C454339",4,0,0,0,0,0,0]
["CB694","CB694","C507920",0,0,2,0,0,0,0]
["CC 1065","CC 1065","C018782",8,0,6,0,3,1,0]
["CD 2019","CD 2019","C101407",0,2,0,0,0,0,0]
["CD6 antigen","CD6 antigen","C062279",0,0,9,0,5,1,0]
["CDRI-85-92","CDRI-85-92","C452083",2,0,0,0,0,0,0]
["cefditoren pivoxil","cefditoren pivoxil","C057710",6,0,0,0,0,0,0]
["Cefmenoxime","Cefmenoxime","D015281",2,1,0,0,0,0,0]
["cefpirome","cefpirome","C038950",12,1,0,0,0,0,0]
["Cellobiose","Cellobiose","D002475",86,3,0,0,1,0,0]
["cellulose tris(3-chloro-4-methylphenylcarbamate)","cellulose tris(3-chloro-4-methylphenylcarbamate)","C538979",4,0,0,0,0,0,0]
["CEP-37440","CEP-37440","C000611391",0,0,3,0,2,0,0]
["Cephradine","Cephradine","D002515",24,0,0,0,0,0,0]
["ceramide N-methylaminoethylphosphonate","ceramide N-methylaminoethylphosphonate","C063234",0,0,2,1,2,0,0]
["cetalkonium chloride","cetalkonium chloride","C012817",4,0,0,0,0,0,0]
["cetylacetyl(imidazol-4-ylmethyl)polyethylenimine","cetylacetyl(imidazol-4-ylmethyl)polyethylenimine","C055354",2,0,0,0,0,0,0]
["CG 400549","CG 400549","C523750",2,0,0,0,0,0,0]
["CGP 20308","CGP 20308","C052584",2,0,0,0,0,0,0]
["CGP 70726","CGP 70726","C413266",2,0,0,0,0,0,0]
["CH 141","CH 141","C045719",8,0,0,0,0,0,0]
["chabranol","chabranol","C545600",0,0,2,0,2,0,0]
["chan-yu-bao-yuan-tang","chan-yu-bao-yuan-tang","C569176",0,0,4,0,6,0,0]
["chelidonine","chelidonine","C062047",0,1,4,0,20,0,0]
["ChemFil II","ChemFil II","C054101",6,0,0,0,0,0,0]
["chimaphilin","chimaphilin","C057774",0,0,4,0,4,0,0]
["chitosan sulfate","chitosan sulfate","C480355",13,0,9,0,0,0,0]
["chitotriose","chitotriose","C041161",4,0,0,0,0,0,0]
["chloramphenicol 3-acetate","chloramphenicol 3-acetate","C026822",2,0,0,0,0,0,0]
["chlorin p6","chlorin p6","C072905",18,3,4,0,8,0,0]
["chloro(1,10-phenanthroline)(N-propylnorfloxacinato)copper(II)","chloro(1,10-phenanthroline)(N-propylnorfloxacinato)copper(II)","C528497",0,1,2,0,1,0,0]
["chloroacetol phosphate","chloroacetol phosphate","C100168",2,0,0,0,0,0,0]
["chlorodibromomethane","chlorodibromomethane","C032707",4,0,0,0,0,0,0]
["chlorophenylguanidine","chlorophenylguanidine","C478080",2,0,0,0,0,0,0]
["chloropinnoite","chloropinnoite","C475672",2,0,0,0,0,0,0]
["Chlorotoxin","Chlorotoxin","C091539",0,0,4,2,2,0,0]
["chlorpyrifos-methyl","chlorpyrifos-methyl","C007031",2,0,0,0,0,0,0]
["cholest-5-ene-3,4-diol","cholest-5-ene-3,4-diol","C099828",0,0,2,0,0,0,0]
["cholesteryl butanoate","cholesteryl butanoate","C092211",0,0,2,0,0,0,0]
["Cholic Acid","Cholic Acid","D019826",43,3,21,0,22,3,0]
["chondroitin sulfate, sodium hyaluronate drug combination","chondroitin sulfate, sodium hyaluronate drug combination","C501944",2,0,0,0,0,0,0]
["chromomycin A2","chromomycin A2","C000594480",0,0,2,0,2,0,0]
["chrysarobin","chrysarobin","C013883",2,0,0,0,0,0,0]
["chrysoplenetin","chrysoplenetin","C472159",0,0,0,0,2,0,0]
["cibacron blue-sepharose","cibacron blue-sepharose","C017842",6,0,0,0,0,0,0]
["cilostamide","cilostamide","C021294",0,0,0,0,1,0,0]
["cimiside E","cimiside E","C545903",0,0,2,0,2,0,0]
["cinnabar","cinnabar","C034211",14,0,0,0,2,0,0]
["cinobufotalin","cinobufotalin","C063451",0,0,6,0,8,0,0]
["cis-(Cr(C2O4)(BaraNH2)(OH2)2)","cis-(Cr(C2O4)(BaraNH2)(OH2)2)","C568723",2,0,0,0,0,0,0]
["Cisapride","Cisapride","D020117",102,0,0,0,1,1,0]
["citral","citral","C007076",32,2,12,0,20,1,0]
["citrus pectin","citrus pectin","C586814",4,0,2,0,4,0,0]
["clausine E","clausine E","C522708",0,0,2,0,0,0,0]
["clauszoline-I","clauszoline-I","C572360",0,0,2,0,0,0,0]
["cleistanthoside A tetraacetate","cleistanthoside A tetraacetate","C579714",2,0,2,0,2,0,0]
["clerosterol","clerosterol","C583592",0,0,0,0,2,0,0]
["Clinitest","Clinitest","C010892",4,0,0,0,0,0,0]
["Clobetasol","Clobetasol","D002990",2,37,4,0,0,0,0]
["clofilium","clofilium","C022799",2,1,0,0,7,1,0]
["Cloprostenol","Cloprostenol","D003008",2,5,2,0,13,0,0]
["C-MED-100","C-MED-100","C406667",0,1,0,0,0,0,0]
["CML-1 plant extract","CML-1 plant extract","C518724",0,0,6,0,5,0,0]
["COB223","COB223","C000604218",0,0,2,1,2,0,0]
["cobra cytotoxin III","cobra cytotoxin III","C055953",0,0,0,0,2,0,0]
["cohumulone","cohumulone","C442487",2,0,0,0,0,0,0]
["Colforsin","Colforsin","D005576",20,7,50,0,46,5,0]
["communesin A","communesin A","C522026",0,0,0,0,0,1,0]
["compound 106","compound 106","C588327",0,0,0,0,2,0,0]
["Congo Red","Congo Red","D003224",153,1,1,0,2,2,0]
["conotoxin GV","conotoxin GV","C055407",0,0,0,0,4,0,0]
["coomassie Brilliant Blue","coomassie Brilliant Blue","C004692",20,0,4,1,20,0,0]
["copper platinum chloride","copper platinum chloride","C422063",2,0,0,0,0,0,0]
["copper-thiosemicarbazone complex","copper-thiosemicarbazone complex","C066363",0,0,2,0,0,0,0]
["coproporphyrin I","coproporphyrin I","C031467",8,1,0,0,0,0,0]
["corilagin","corilagin","C049096",0,0,8,0,10,0,0]
["coronene","coronene","C012256",2,0,2,0,0,0,0]
["cosalane","cosalane","C083060",2,0,0,0,0,0,0]
["cotylenin A","cotylenin A","C423222",0,0,14,0,9,0,0]
["CP 41","CP 41","C108009",2,0,0,0,0,0,0]
["CPDA solutions","CPDA solutions","C034876",11,0,0,0,0,1,0]
["CPUYS707","CPUYS707","C575129",0,0,2,0,0,0,0]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C11396,B11396)","v":"crambescidin 800"},"crambescidin 800","C490355",0,0,2,0,4,0,0]
["Creosote","Creosote","D003407",8,2,0,0,0,0,0]
["Crest Gum Care","Crest Gum Care","C098421",6,0,0,0,0,0,0]
["Croton Oil","Croton Oil","D003436",0,7,2,0,4,0,0]
["cryptating agent 221","cryptating agent 221","C053547",2,0,0,0,0,0,0]
["crystalloid solutions","crystalloid solutions","C007162",142,0,0,0,0,0,0]
["Cucumis trigonus extract","Cucumis trigonus extract","C028646",4,0,0,0,0,0,0]
["cucurbitacin IIa","cucurbitacin IIa","C557526",0,0,0,0,2,0,0]
["cudraflavone B","cudraflavone B","C542041",0,0,4,0,2,0,0]
["cupferron","cupferron","C031808",8,0,0,0,0,0,0]
["Curare","Curare","D003472",11,1,0,0,0,0,0]
["cutin","cutin","C000521",8,0,0,0,0,1,0]
["CX 3543","CX 3543","C545184",0,0,0,0,2,0,0]
["cyanine dye 5","cyanine dye 5","C085321",4,0,3,0,2,0,0]
["cyanohydrin","cyanohydrin","C430593",4,0,0,0,0,0,0]
["cyathins","cyathins","C007179",0,0,0,0,2,0,0]
["cyclic DTPA anhydride","cyclic DTPA anhydride","C039777",2,0,0,0,0,0,0]
["cycloartenyl ferulate","cycloartenyl ferulate","C540967",0,0,0,0,6,0,0]
["cyclodextrin-epichlorohydrin polymer","cyclodextrin-epichlorohydrin polymer","C102558",2,0,0,0,0,0,0]
["cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester","cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester","C500528",2,0,2,0,7,0,0]
["cyclohexyl methylphosphonic acid","cyclohexyl methylphosphonic acid","C073636",2,0,0,0,0,0,0]
["cyclophane 1","cyclophane 1","C121239",2,0,0,0,0,0,0]
["cylindrospermopsin","cylindrospermopsin","C089595",20,3,15,0,18,0,0]
["cypripedin","cypripedin","C021986",0,0,0,0,2,0,0]
["Cystaphos","Cystaphos","D003539",2,0,0,0,0,0,0]
["cytolysin III (Stoichactis helianthus)","cytolysin III (Stoichactis helianthus)","C038137",0,0,2,0,2,0,0]
["CZ415 compound","CZ415 compound","C000621007",0,0,2,0,2,0,0]
["Dabigatran","Dabigatran","D000069604",4,5,4,0,0,0,0]
["Da-Cheng-Qi","Da-Cheng-Qi","C551430",0,1,0,0,2,0,0]
["damsin","damsin","C012266",0,0,3,0,0,0,0]
["dansyl hydrazine","dansyl hydrazine","C027913",4,0,0,0,1,0,0]
["dansylgalactosamine","dansylgalactosamine","C041456",2,0,0,0,0,0,0]
["DAPI","DAPI","C007293",32,1,2,0,14,0,0]
["DAUFmor compound","DAUFmor compound","C584765",0,2,0,0,3,0,0]
["dazmegrel","dazmegrel","C039242",2,2,0,0,2,0,0]
["DDP733","DDP733","C527576",2,0,0,0,0,0,0]
["DEAE-Cellulose","DEAE-Cellulose","D003636",22,0,0,0,0,0,0]
["decamethrin","decamethrin","C017180",16,1,5,0,59,3,0]
["decumbenone B","decumbenone B","C470966",0,0,2,0,0,0,0]
["deferasirox","deferasirox","C415250",4,2,34,2,45,0,0]
["DegraPol","DegraPol","C104154",2,0,4,0,1,0,0]
["dehydroandrographolide","dehydroandrographolide","C478098",4,0,2,0,0,0,0]
["dehydroeffusol","dehydroeffusol","C573784",0,0,0,1,2,0,0]
["dehydroxymethylepoxyquinomicin","dehydroxymethylepoxyquinomicin","C464444",0,0,30,0,71,0,0]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C11908,B11908)","v":"Delor 106"},"Delor 106","C073236",0,0,0,0,2,0,0]
["deltanit","deltanit","C052300",0,0,2,0,0,0,0]
["demethylcitalopram","demethylcitalopram","C514709",2,0,0,0,0,0,0]
["demethylfruticuline A","demethylfruticuline A","C539555",0,0,2,0,2,0,0]
["dendrotoxin","dendrotoxin","C020273",4,0,2,0,0,1,0]
["deoxyapoaranotin","deoxyapoaranotin","C558011",0,0,0,0,1,0,0]
["deoxynivalenol","deoxynivalenol","C007262",44,5,62,2,135,1,0]
["depsidone","depsidone","C000875",0,0,2,0,2,0,0]
["derricin","derricin","C000604275",0,0,2,0,0,0,0]
["desmethylicaritin","desmethylicaritin","C499404",0,0,4,0,2,0,0]
["desmethylselegiline","desmethylselegiline","C017861",0,0,0,0,3,0,0]
["Devazepide","Devazepide","D020109",2,4,0,0,2,1,0]
["Dexrazoxane","Dexrazoxane","D064730",0,1,4,0,14,0,0]
["Dextran Sulfate","Dextran Sulfate","D016264",101,5,39,0,51,0,0]
["D-glycero-D-talo heptitol","D-glycero-D-talo heptitol","C000620899",0,0,2,0,0,0,0]
["di huang yin zi","di huang yin zi","C582425",0,0,0,0,2,0,0]
["di-2-pyridyl ketone isonicotinoyl hydrazone","di-2-pyridyl ketone isonicotinoyl hydrazone","C511462",0,0,2,0,2,0,0]
["diacetylmonoxime","diacetylmonoxime","C004717",12,3,1,0,8,0,0]
["diammineplatinum(IV) tetrachloride","diammineplatinum(IV) tetrachloride","C501018",2,0,0,0,0,0,0]
["dianhydro-3,4-diacetylgalactitol","dianhydro-3,4-diacetylgalactitol","C027991",0,0,2,0,4,0,0]
["diaziquone","diaziquone","C029108",16,0,0,0,0,0,0]
["Dibekacin","Dibekacin","D003982",4,3,0,0,0,0,0]
["dibenzo(b,d)thiophene tethered imidazo(1,2-a)pyridine-3-carboxamide","dibenzo(b,d)thiophene tethered imidazo(1,2-a)pyridine-3-carboxamide","C000620936",0,0,2,0,0,0,0]
["dibromoacetic acid","dibromoacetic acid","C088674",4,1,2,0,6,0,0]
["dibromoacetonitrile","dibromoacetonitrile","C051715",2,0,0,0,2,0,0]
["dibutyltin dilaurate","dibutyltin dilaurate","C010409",0,2,0,0,0,0,0]
["dichloro(4-cymene)(1,3,5-triaza-7-phosphatricyclo(3.3.1.1)decane)ruthenium(II)","dichloro(4-cymene)(1,3,5-triaza-7-phosphatricyclo(3.3.1.1)decane)ruthenium(II)","C530402",0,0,4,0,2,0,0]
["dichloro(methyl N-(dithiocarboxy-kS,kS')-N-methylglicinato)gold(III)","dichloro(methyl N-(dithiocarboxy-kS,kS')-N-methylglicinato)gold(III)","C518839",0,0,2,0,2,0,0]
["Dichlorodiphenyldichloroethane","Dichlorodiphenyldichloroethane","D003632",10,8,2,0,4,0,0]
["diclofenac hydroxyethylpyrrolidine","diclofenac hydroxyethylpyrrolidine","C064142",2,0,0,0,0,0,0]
["dicrotophos","dicrotophos","C000944",0,0,0,0,2,0,0]
["Dicyclohexylcarbodiimide","Dicyclohexylcarbodiimide","D004024",90,0,2,0,0,1,0]
["didemnaketal G","didemnaketal G","C000599726",0,0,2,0,0,0,0]
["diethyl 2-amino-5-(((5-nitrofuran-2-yl)methylidene)amino)thiophene-3,4-dicarboxylate","diethyl 2-amino-5-(((5-nitrofuran-2-yl)methylidene)amino)thiophene-3,4-dicarboxylate","C000596767",0,0,2,0,0,0,0]
["diethyl(2-methyl-2-pyrrolidinyl)phosphonate","diethyl(2-methyl-2-pyrrolidinyl)phosphonate","C113107",4,0,0,0,0,0,0]
["diethylene glycol monomethyl ether","diethylene glycol monomethyl ether","C048214",3,0,2,0,4,0,0]
["diffusomycin","diffusomycin","C077919",2,0,0,0,0,0,0]
["difructose anhydride I","difructose anhydride I","C036365",6,0,0,0,0,0,0]
["Digitoxin","Digitoxin","D004074",28,6,20,1,16,0,0]
["dihydroaustrasulfone alcohol","dihydroaustrasulfone alcohol","C000590752",0,0,8,1,0,0,0]
["dihydrobetulinic acid","dihydrobetulinic acid","C098641",0,0,2,0,4,0,0]
["Dihydroergocristine","Dihydroergocristine","D025442",2,0,0,0,0,0,0]
["dihydroouabain","dihydroouabain","C000977",2,0,0,0,0,0,0]
["dihydrosterculic acid","dihydrosterculic acid","C029355",0,0,2,0,2,0,0]
["dihydroxy-isosteviol-methyl-ester","dihydroxy-isosteviol-methyl-ester","C579618",0,0,0,0,2,0,0]
["diisoeugenol","diisoeugenol","C087580",0,0,0,0,2,0,0]
["Diltiazem","Diltiazem","D004110",156,12,8,0,22,1,0]
["dimercaptosuccinic acid monomethyl ester","dimercaptosuccinic acid monomethyl ester","C071157",2,0,0,0,0,0,0]
["dimethoxon","dimethoxon","C002302",6,0,0,0,0,1,0]
["dimethyl pyrocarbonate","dimethyl pyrocarbonate","C061815",2,0,0,0,0,0,0]
["dimethylamide-crotonin","dimethylamide-crotonin","C475025",0,0,0,0,4,0,0]
["dimethylenastron","dimethylenastron","C518969",0,0,8,0,2,0,0]
["dimethyltin","dimethyltin","C039760",12,0,0,0,2,0,0]
["dinaciclib","dinaciclib","C553669",0,0,17,0,29,0,0]
["dinobuton","dinobuton","C004789",2,0,0,0,0,0,0]
["di-n-pentyl phthalate","di-n-pentyl phthalate","C034171",0,2,0,0,0,0,0]
["dioleoylphosphatidic acid","dioleoylphosphatidic acid","C037657",8,0,0,0,0,0,0]
["diosgenyl rhamnopyranosyl-(1-2)-(xylopyranosyl-(1-4))arabinopyranoside","diosgenyl rhamnopyranosyl-(1-2)-(xylopyranosyl-(1-4))arabinopyranoside","C000599089",0,0,0,0,2,0,0]
["diperoxovanadate","diperoxovanadate","C091767",12,0,0,0,0,0,0]
["diphenylborinic acid","diphenylborinic acid","C044960",2,0,0,0,0,0,0]
["diphenylthiohydantoin","diphenylthiohydantoin","C073336",0,0,2,0,0,0,0]
["Diphtheria-Tetanus-Pertussis Vaccine","Diphtheria-Tetanus-Pertussis Vaccine","D015721",0,4,3,0,0,0,0]
["dipyrido(3,2-a-2',3'-c)phenazine","dipyrido(3,2-a-2',3'-c)phenazine","C443808",0,0,0,0,4,0,0]
["direct black 19","direct black 19","C049357",2,0,0,0,0,0,0]
["direct yellow","direct yellow","C502684",4,0,0,0,0,0,0]
["disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate","disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate","C076126",0,0,4,0,0,0,0]
["Disperse Orange 1","Disperse Orange 1","C556349",0,0,0,0,2,0,0]
["disuccinimidyl suberate","disuccinimidyl suberate","C019358",4,0,0,0,0,0,0]
["dithiobis(4-butyrylamino-m-phenylboronic acid)","dithiobis(4-butyrylamino-m-phenylboronic acid)","C510907",2,0,0,0,0,0,0]
["Dithionitrobenzoic Acid","Dithionitrobenzoic Acid","D004228",60,0,0,0,0,0,0]
["DK-AH 268","DK-AH 268","C087873",2,0,0,0,0,0,0]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C12740,B12740)","v":"DMP 406"},"DMP 406","C118280",0,0,0,0,2,0,0]
["Dodecanol","Dodecanol","D007851",16,0,2,0,0,0,0]
["dodecyl sulfobetaine","dodecyl sulfobetaine","C500979",4,0,0,0,0,0,0]
["Dolichol Monophosphate Mannose","Dolichol Monophosphate Mannose","D004287",4,0,0,0,0,0,0]
["dong quai","dong quai","C109695",0,0,2,0,6,0,0]
["dotriacontane","dotriacontane","C578748",2,0,0,0,0,0,0]
["doxorubicin-cobalt(II) complex","doxorubicin-cobalt(II) complex","C053170",2,0,0,0,0,0,0]
["DQ 2556","DQ 2556","C050465",2,0,0,0,0,0,0]
["DRAQ5NO","DRAQ5NO","C406029",0,0,0,0,1,0,0]
["droxicam","droxicam","C049073",2,0,0,0,0,0,0]
["DT 5461","DT 5461","C077208",0,0,0,1,0,0,0]
["duocarmycin B1","duocarmycin B1","C060648",4,0,0,0,0,0,0]
["dyclonine","dyclonine","C100063",2,0,0,0,2,0,0]
["DYZ-2-90","DYZ-2-90","C581519",0,0,0,0,2,0,0]
["E 3604","E 3604","C053455",2,0,0,0,0,0,0]
["E671 bisindole","E671 bisindole","C509868",0,0,0,0,1,0,0]
["EBI-907","EBI-907","C000611488",0,0,2,0,0,0,0]
["Ecasol","Ecasol","C545343",2,0,2,0,0,0,0]
["echinocystic acid","echinocystic acid","C022999",0,0,0,0,7,0,0]
["EF25-(GSH)2","EF25-(GSH)2","C000598849",0,0,2,0,1,0,0]
["eglumetad","eglumetad","C104753",0,0,0,0,2,0,0]
["EGP-2 antigen, human","EGP-2 antigen, human","C478989",0,0,0,0,3,0,0]
["elemane aldehyde","elemane aldehyde","C579703",0,0,2,0,2,0,0]
["eleutheroside E","eleutheroside E","C421885",0,0,2,0,0,0,0]
["ellipticine","ellipticine","C034192",28,2,30,0,35,3,0]
["embellistatin","embellistatin","C517529",0,0,0,1,0,0,0]
["emedastine","emedastine","C043345",4,1,0,0,0,0,0]
["Emser Salt","Emser Salt","C427003",4,0,0,0,0,0,0]
["endosulfan sulfate","endosulfan sulfate","C544689",0,0,0,0,2,0,0]
["enhydrin","enhydrin","C521984",0,0,0,0,2,0,0]
["enrofloxacin","enrofloxacin","C052904",60,3,7,0,7,1,0]
["enterotoxin D, Staphylococcal","enterotoxin D, Staphylococcal","C019368",4,1,1,0,2,0,0]
["enterotoxin, Bacillus cereus","enterotoxin, Bacillus cereus","C040792",6,0,0,0,0,0,0]
["eosinylphosphatidylethanolamine","eosinylphosphatidylethanolamine","C059736",2,0,0,0,0,0,0]
["epilactose","epilactose","C047464",2,0,0,0,0,0,0]
["epimedin C","epimedin C","C106054",2,0,1,1,0,0,0]
["eprinomectin","eprinomectin","C101434",4,0,0,0,0,0,0]
["EPZ-5676","EPZ-5676","C583893",0,0,3,0,0,0,0]
["ERB 041","ERB 041","C478102",0,0,2,0,0,0,0]
["ergolide","ergolide","C099797",0,0,0,0,2,0,0]
["Eriochrome Black T","Eriochrome Black T","C014527",12,0,0,1,0,0,0]
["eritoran","eritoran","C512420",0,0,4,0,3,0,0]
["erucyl amide","erucyl amide","C049508",0,0,0,1,0,0,0]
["erythrocarpine E","erythrocarpine E","C569836",0,0,2,0,2,0,0]
["ESAT-6 antigen, Mycobacterium leprae","ESAT-6 antigen, Mycobacterium leprae","C525005",0,0,0,0,2,0,0]
["esmolol","esmolol","C036604",15,0,0,0,5,0,0]
["Etanidazole","Etanidazole","D017341",10,5,4,2,6,0,0]
["ethane sulfonate","ethane sulfonate","C002634",0,1,0,0,0,0,0]
["ethaselen-1","ethaselen-1","C529432",0,0,2,0,0,0,0]
["ethoxylated bis-phenol A dimethacrylate","ethoxylated bis-phenol A dimethacrylate","C074277",2,0,0,0,0,0,0]
["ethyl 2-cyanoacrylate","ethyl 2-cyanoacrylate","C029054",2,2,2,0,0,0,0]
["ethyl 3,5-dimethyl-4-((indolin-2-one-3-ylidene)methyl)-1H-pyrrole-2-carboxylate","ethyl 3,5-dimethyl-4-((indolin-2-one-3-ylidene)methyl)-1H-pyrrole-2-carboxylate","C547915",0,0,2,0,0,0,0]
["ethyl 6-(5-(phenylsulfonamido)pyridin-3-yl)imidazo(1,2-a)pyridine-3-carboxylate","ethyl 6-(5-(phenylsulfonamido)pyridin-3-yl)imidazo(1,2-a)pyridine-3-carboxylate","C577242",0,0,10,2,12,0,0]
["ethyl caffeate","ethyl caffeate","C032773",2,0,4,0,2,0,0]
["ethyl isothiocyanate","ethyl isothiocyanate","C039155",0,0,2,0,2,0,0]
["ethyl propiolate","ethyl propiolate","C544697",6,0,0,0,0,0,0]
["ethyl-4-S-cysteaminylphenol","ethyl-4-S-cysteaminylphenol","C494919",0,0,2,0,0,0,0]
["ethylene glycol monoethyl ether acetate","ethylene glycol monoethyl ether acetate","C022278",0,1,0,0,0,0,0]
["Ethylenebis(dithiocarbamates)","Ethylenebis(dithiocarbamates)","D005028",2,0,2,0,4,0,0]
["ethylhydrocupreine","ethylhydrocupreine","C017303",0,0,0,0,0,1,0]
["Etilefrine","Etilefrine","D005039",3,0,0,0,0,0,0]
["etofylline","etofylline","C008749",2,0,1,0,0,0,0]
["etridiazol","etridiazol","C014547",2,0,0,0,0,0,0]
["Eudragit NE 30-D","Eudragit NE 30-D","C477853",10,0,0,0,0,0,0]
["eukovoside","eukovoside","C488309",2,0,0,0,0,0,0]
["eupatilin","eupatilin","C045325",0,1,15,0,27,0,0]
["euplotin C","euplotin C","C493253",2,0,0,0,5,0,0]
["evocarpine","evocarpine","C059242",0,0,0,0,2,0,0]
["exopolysaccharide, Enterobacter amnigenus","exopolysaccharide, Enterobacter amnigenus","C503194",2,0,0,0,0,0,0]
["exopolysaccharide, Pseudomonas","exopolysaccharide, Pseudomonas","C064841",2,1,0,0,0,1,0]
["factor F430","factor F430","C023540",2,0,0,0,0,0,0]
["Famotidine","Famotidine","D015738",246,4,2,4,2,0,0]
["farnesyl anthranilate","farnesyl anthranilate","C413602",0,0,0,0,2,0,0]
["Fasnall compound","Fasnall compound","C000624393",0,0,2,0,0,0,0]
["Fast Violet B","Fast Violet B","C067037",2,0,0,0,0,0,0]
["FDC blue lake no.2","FDC blue lake no.2","C025129",2,0,0,0,0,0,0]
["Fendiline","Fendiline","D005275",0,0,4,0,0,0,0]
["fenofibric acid","fenofibric acid","C006012",2,0,0,0,2,0,0]
["Fenretinide","Fenretinide","D017313",4,6,66,12,414,0,0]
["feralex","feralex","C447640",2,0,0,0,0,0,0]
["ferric oxide","ferric oxide","C000499",822,15,145,19,110,4,0]
["ferriprotoporphyrin IX-chloroquine complex","ferriprotoporphyrin IX-chloroquine complex","C069269",2,0,0,0,0,0,0]
["ferrochromium","ferrochromium","C027393",4,0,0,0,0,0,0]
["ferrous oxide","ferrous oxide","C034236",28,1,2,0,5,0,0]
["fibrinogen-related antigen","fibrinogen-related antigen","C023456",0,2,0,0,0,0,0]
["Ficoll","Ficoll","D005362",10,0,1,0,1,0,0]
["FK 3311","FK 3311","C085566",2,0,0,0,0,0,0]
["flavipin","flavipin","C000621062",0,0,2,0,0,0,0]
["flavopereirine","flavopereirine","C034262",2,0,0,0,0,0,0]
["flexibilisin B","flexibilisin B","C546133",0,0,2,0,0,0,0]
["flor-essence","flor-essence","C488083",0,0,1,0,0,0,0]
["fluazuron","fluazuron","C104929",0,0,0,0,2,0,0]
["Flunarizine","Flunarizine","D005444",22,3,0,0,12,0,0]
["fluocinolone","fluocinolone","C035394",0,0,2,0,0,0,0]
["fluorenone oxime","fluorenone oxime","C017876",2,0,0,0,0,0,0]
["fluoresceinated methotrexate","fluoresceinated methotrexate","C036539",4,0,0,0,0,0,0]
["fluoroazomycin arabinoside","fluoroazomycin arabinoside","C498052",0,0,2,3,0,0,0]
["fluoroform","fluoroform","C009554",2,0,0,0,0,0,0]
["fluorotelomer acrylate","fluorotelomer acrylate","C540553",2,0,0,0,0,0,0]
["fluprednidene acetate","fluprednidene acetate","C100064",0,1,0,0,0,0,0]
["Flurothyl","Flurothyl","D005481",2,0,0,0,2,0,0]
["FM 4-64","FM 4-64","C092350",4,0,0,0,0,0,0]
["formamidoxime","formamidoxime","C001250",2,0,0,0,0,0,0]
["formocresol","formocresol","C031025",0,4,0,0,1,1,0]
["fortimicins","fortimicins","C023521",2,0,0,0,0,0,0]
["fosmidomycin","fosmidomycin","C024640",4,0,2,0,0,0,0]
["FPL 57231","FPL 57231","C034338",2,0,0,0,0,0,0]
["FR 186054","FR 186054","C112873",0,1,0,0,0,0,0]
["frondosin A","frondosin A","C524890",0,0,2,1,2,0,0]
["Fructose","Fructose","D005632",543,18,44,2,79,3,0]
["Fucose","Fucose","D005643",140,4,21,2,16,3,0]
["fuji IX","fuji IX","C110713",16,0,2,0,0,0,0]
["fumagillin","fumagillin","C026211",4,0,13,24,2,0,0]
["fura red","fura red","C082877",2,0,0,0,0,0,0]
["furaneol","furaneol","C058427",8,0,0,0,0,0,0]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C14084,B14084)","v":"furfuryl methacrylate"},"furfuryl methacrylate","C085853",0,0,1,0,0,0,0]
["fustin","fustin","C522894",0,0,2,0,3,0,0]
["futoxide","futoxide","C011828",0,0,2,0,2,0,0]
["G244-LM","G244-LM","C582304",0,0,2,0,0,0,0]
["gabaculine","gabaculine","C012987",2,0,0,0,0,1,0]
["gadolinium(III) 1,2-hydroxypyridonate","gadolinium(III) 1,2-hydroxypyridonate","C500102",2,0,0,0,0,0,0]
["galactaric acid","galactaric acid","C000090",8,0,2,0,2,0,0]
["galactosyl-(1-3)galactose","galactosyl-(1-3)galactose","C055075",2,0,2,0,4,1,0]
["gallocatechin gallate","gallocatechin gallate","C417940",4,0,0,1,3,0,0]
["gambierol","gambierol","C435770",0,0,4,0,0,0,0]
["gamma-eudesmol","gamma-eudesmol","C499668",0,0,2,0,2,0,0]
["ganglioside, GD2","ganglioside, GD2","C019403",2,0,18,1,21,1,0]
["ganoderic acid S","ganoderic acid S","C572163",0,0,0,0,2,0,0]
["gapicomine","gapicomine","C009853",3,0,0,0,0,0,0]
["GC 1 compound","GC 1 compound","C413355",0,0,9,0,0,0,0]
["Gd-DOTA-4amP","Gd-DOTA-4amP","C471303",4,0,0,0,0,0,0]
["gelsemine","gelsemine","C063230",2,0,2,0,2,0,0]
["geneserine","geneserine","C060406",2,0,0,0,0,0,0]
["genistin","genistin","C040641",12,4,8,1,12,0,0]
["geranyl pyrophosphate","geranyl pyrophosphate","C015234",4,0,0,0,0,0,0]
["germanicol acetate","germanicol acetate","C110693",0,0,0,0,2,0,0]
["GGTI-2154","GGTI-2154","C482418",0,1,0,0,2,0,0]
["gilvocarcin V","gilvocarcin V","C031781",0,0,4,0,0,1,0]
["ginsenoside 20S-protopanaxatriol","ginsenoside 20S-protopanaxatriol","C507965",0,0,4,0,6,0,0]
["ginsenoside Rg2","ginsenoside Rg2","C026474",0,0,2,0,13,0,0]
["ginsenoside Rh2 20,24-epoxide","ginsenoside Rh2 20,24-epoxide","C000613467",0,0,2,0,2,0,0]
["gintonin","gintonin","C000603040",0,0,4,0,0,0,0]
["glass ionomer","glass ionomer","C015897",6,0,0,0,0,0,0]
["Gliclazide","Gliclazide","D005907",42,0,2,0,18,0,0]
["globotetraose","globotetraose","C035968",0,0,0,0,0,1,0]
["glucogallin","glucogallin","C060474",2,0,0,0,2,0,0]
["glucosaminic acid","glucosaminic acid","C035547",6,0,0,0,0,0,0]
["glucose, glycerol, hydroxyethyl starch, perfluorodecalin, perfluorotripropylamine, pluronic F-68, salts, yolk phospholipids drug combination","glucose, glycerol, hydroxyethyl starch, perfluorodecalin, perfluorotripropylamine, pluronic F-68, salts, yolk phospholipids drug combination","C017323",24,5,0,0,0,0,0]
["Glucuronic Acid","Glucuronic Acid","D020723",76,0,19,2,5,1,0]
["glutaryl phosphatidylcholine","glutaryl phosphatidylcholine","C029316",2,0,0,0,0,0,0]
["glycerol dialkyl nonitol tetraethyl ether","glycerol dialkyl nonitol tetraethyl ether","C085775",2,0,0,0,0,0,0]
["glycidyl 4-nitrobenzoate","glycidyl 4-nitrobenzoate","C546586",0,0,0,0,0,2,0]
["glycitin","glycitin","C433283",4,1,5,0,2,0,0]
["glycoluril","glycoluril","C092018",4,0,0,0,0,0,0]
["Glycyrrhetinic Acid","Glycyrrhetinic Acid","D006034",48,16,103,2,113,0,0]
["GN25 compound","GN25 compound","C587449",0,0,2,0,2,0,0]
["gnidimacrin","gnidimacrin","C013006",0,0,2,0,0,0,0]
["Gold Sodium Thiosulfate","Gold Sodium Thiosulfate","D012971",4,0,0,0,0,0,0]
["GP 7","GP 7","C071346",0,0,2,0,8,0,0]
["GR 63799X","GR 63799X","C067522",0,0,2,0,0,0,0]
["grandisin","grandisin","C074346",0,0,2,1,0,0,0]
["griffithin","griffithin","C529099",0,0,2,0,2,0,0]
["GSK 1838705A","GSK 1838705A","C546191",0,0,4,0,2,0,0]
["GSK1325756","GSK1325756","C581951",2,0,0,0,0,0,0]
["GT0918","GT0918","C000599887",2,0,0,0,0,0,0]
["guanacastepene E","guanacastepene E","C516935",0,0,0,0,2,0,0]
["guanidine biboric acid adduct","guanidine biboric acid adduct","C117044",0,0,0,0,4,0,0]
["guizhi-fuling","guizhi-fuling","C525079",0,0,2,1,4,0,0]
["GutGard","GutGard","C554040",3,0,0,0,0,0,0]
["GW 4064","GW 4064","C412815",0,0,6,0,6,0,0]
["GW8510","GW8510","C500810",0,0,0,0,3,0,0]
["gymnodimine","gymnodimine","C407350",2,0,0,0,0,0,0]
["H-2A antigen","H-2A antigen","C108513",0,0,0,0,1,0,0]
["HABA","HABA","C001413",4,0,0,0,0,0,0]
["haloperidol decanoate","haloperidol decanoate","C033563",0,0,2,0,0,0,0]
["Harmine","Harmine","D006247",35,0,46,2,50,1,0]
["HBME-1 antigen","HBME-1 antigen","C432845",0,1,1,0,0,0,0]
["hederacolchisid A1","hederacolchisid A1","C467827",0,0,2,1,4,0,0]
["heliomycin","heliomycin","C007912",0,0,2,0,2,0,0]
["hematein","hematein","C007915",8,0,0,0,4,0,0]
["heme a","heme a","C027728",26,0,1,0,0,0,0]
["hemicellulose","hemicellulose","C007916",114,0,8,0,0,0,0]
["heparin, N-desulfated","heparin, N-desulfated","C044153",0,0,0,1,0,0,0]
["heptakis(2,3,6-tri-O-methyl)cyclomaltoheptaose","heptakis(2,3,6-tri-O-methyl)cyclomaltoheptaose","C487420",4,0,0,0,0,0,0]
["heptakis-6-sulfato-beta-cyclodextrin","heptakis-6-sulfato-beta-cyclodextrin","C475632",2,0,0,0,0,0,0]
["herbal compound 861","herbal compound 861","C476499",0,0,2,0,2,0,0]
["herniarin","herniarin","C007929",0,0,2,0,0,0,0]
["heteronemin","heteronemin","C493748",0,0,8,0,10,0,0]
["hexachlorobutadiene","hexachlorobutadiene","C001335",2,3,0,0,2,0,0]
["hexadeca-4,7,10,13-tetraenoic acid","hexadeca-4,7,10,13-tetraenoic acid","C562199",0,0,0,0,2,0,0]
["hexafluorosilicate","hexafluorosilicate","C004832",12,0,0,0,2,0,0]
["Hexavac","Hexavac","C426944",0,0,1,0,0,0,0]
["hexyl laurate","hexyl laurate","C514485",2,0,0,0,0,0,0]
["HG-7-86-01","HG-7-86-01","C576477",0,0,2,0,0,0,0]
["himbacine","himbacine","C048172",2,0,0,0,0,0,0]
["hirsutanol A","hirsutanol A","C569055",0,0,6,0,5,0,0]
["histamine trifluoromethyl-toluidide","histamine trifluoromethyl-toluidide","C087869",0,0,2,0,0,0,0]
["HKI 46F08","HKI 46F08","C534527",0,0,2,0,2,0,0]
["HMQ18-22","HMQ18-22","C577310",0,0,2,0,0,0,0]
["Homogentisic Acid","Homogentisic Acid","D006713",6,1,0,0,2,1,0]
["horminone","horminone","C045490",0,0,0,0,2,0,0]
["HPMA coploymer-doxorubicin-galactosamine","HPMA coploymer-doxorubicin-galactosamine","C438845",2,0,2,0,2,0,0]
["HTH-01-015","HTH-01-015","C586756",0,0,2,0,0,0,0]
["huang-lien-chieh-tu-tang","huang-lien-chieh-tu-tang","C045607",0,0,4,0,2,0,0]
["huperzine B","huperzine B","C053016",2,0,0,0,0,0,0]
["Hydralazine","Hydralazine","D006830",54,31,13,4,14,0,0]
["hydratropic acid","hydratropic acid","C013025",4,0,0,0,0,0,0]
["hydroperoxyisophosphamide","hydroperoxyisophosphamide","C012353",0,0,0,0,2,0,0]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C15172,B15172)","v":"hydrostannane"},"hydrostannane","C510267",0,0,2,0,0,0,0]
["hydroxyethyl methacrylate-methacrylic acid-ethyl methacrylate copolymer","hydroxyethyl methacrylate-methacrylic acid-ethyl methacrylate copolymer","C063229",2,0,0,0,0,0,0]
["hydroxyfluorapatite","hydroxyfluorapatite","C488645",2,0,0,0,0,0,0]
["hydroxylamine-O-sulfonic acid","hydroxylamine-O-sulfonic acid","C008042",2,0,0,0,0,0,0]
["hydroxypropyl distarch phosphate","hydroxypropyl distarch phosphate","C050767",4,0,0,0,0,0,0]
["hydroxyspheroidene","hydroxyspheroidene","C005638",0,0,0,0,0,1,0]
["hylan","hylan","C049816",0,0,2,0,4,0,0]
["hypoestoxide","hypoestoxide","C432343",0,0,2,0,0,0,0]
["iberogast","iberogast","C039964",0,0,2,0,4,0,0]
["ibutilide","ibutilide","C067192",4,0,0,0,4,1,0]
["ICI 215001","ICI 215001","C076355",2,0,0,0,0,0,0]
["Idarubicin","Idarubicin","D015255",16,2,20,1,72,2,0]
["IDN 5109","IDN 5109","C404743",0,0,2,2,6,0,0]
["iejimalide C","iejimalide C","C520299",0,0,2,0,0,0,0]
["ikarugamycin","ikarugamycin","C074292",0,0,0,0,2,0,0]
["imidapril","imidapril","C065166",4,0,0,1,4,0,0]
["imidazo(1,2-a)pyrimidine","imidazo(1,2-a)pyrimidine","C000607116",0,0,2,0,0,0,0]
["Imipenem","Imipenem","D015378",24,8,0,0,0,1,0]
["IMP1338","IMP1338","C000613086",0,0,2,0,2,0,0]
["INCB018424","INCB018424","C540383",2,0,29,0,26,0,0]
["indanomycin","indanomycin","C114124",0,0,0,0,0,1,0]
["indeno(1,2-b)indole","indeno(1,2-b)indole","C000606774",0,0,2,0,0,0,0]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C15428,B15428)","v":"Indigo Carmine"},"Indigo Carmine","D007203",39,0,2,2,2,0,0]
["indole-3-acetic acid ethyl ester","indole-3-acetic acid ethyl ester","C070971",0,0,0,0,0,1,0]
["indoline-2,3-dione","indoline-2,3-dione","C572590",0,0,2,0,0,0,0]
["Indoprofen","Indoprofen","D007216",4,0,0,0,0,0,0]
["Indoxamycin B","Indoxamycin B","C545165",0,0,2,0,0,0,0]
["INK128","INK128","C572449",0,1,22,1,20,0,0]
["inositol 1,4-bis(phosphate)","inositol 1,4-bis(phosphate)","C044259",4,0,0,0,0,0,0]
["inositol phosphate glycan","inositol phosphate glycan","C028039",6,0,0,0,0,0,0]
["inotodiol","inotodiol","C517091",0,0,4,0,6,0,0]
["iodobenzene","iodobenzene","C031905",0,3,0,0,0,0,0]
["Iodoquinol","Iodoquinol","D004103",8,0,0,0,0,0,0]
["iomeprol","iomeprol","C057937",2,0,2,5,4,0,0]
["IPA-3 compound","IPA-3 compound","C541795",0,0,8,0,6,0,0]
["ipragliflozin","ipragliflozin","C572941",0,0,2,0,0,0,0]
["irampanel","irampanel","C119322",2,0,0,0,0,0,0]
["irilone","irilone","C530234",0,0,4,0,0,0,0]
["iron bis(1,2-dimethylphosphino)ethane complex","iron bis(1,2-dimethylphosphino)ethane complex","C050346",2,0,0,0,0,0,0]
["iron(III)-tetraphenylporphyrin","iron(III)-tetraphenylporphyrin","C510466",2,0,0,0,0,0,0]
["isatin 3-picolinoyl hydrazone","isatin 3-picolinoyl hydrazone","C490229",0,0,0,0,1,0,0]
["ISIR-042","ISIR-042","C000605940",0,0,4,0,2,0,0]
["isobutyl alcohol","isobutyl alcohol","C040507",4,0,0,0,0,3,0]
["isocampneoside II","isocampneoside II","C587325",0,0,0,0,2,0,0]
["isochamaejasmin","isochamaejasmin","C507044",0,0,0,0,4,0,0]
["isoeugenol","isoeugenol","C036643",7,1,6,0,0,0,0]
["isoglobotriaosylceramide","isoglobotriaosylceramide","C037097",2,0,0,0,0,0,0]
["isointermedeol","isointermedeol","C528862",0,0,2,0,2,0,0]
["isomandelalide A","isomandelalide A","C000611641",0,0,2,0,0,0,0]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C15748,B15748)","v":"isoneorautenol"},"isoneorautenol","C000593596",0,0,0,0,2,0,0]
["isopomiferin","isopomiferin","C533098",2,0,2,0,0,0,0]
["isopropyl methylphosphonic acid","isopropyl methylphosphonic acid","C048760",2,0,0,0,0,0,0]
["isoquinoline-3-carboxylic acid","isoquinoline-3-carboxylic acid","C000606691",0,0,2,0,2,0,0]
["isoschisandrolic acid","isoschisandrolic acid","C522400",0,0,0,0,2,0,0]
["isosorbide-2,5-diaspirinate","isosorbide-2,5-diaspirinate","C534491",2,0,0,0,0,0,0]
["isovaleric acid","isovaleric acid","C008216",16,0,2,0,0,0,0]
["isoxicam","isoxicam","C013580",6,0,0,0,0,0,0]
["J 104132","J 104132","C119319",4,0,0,0,0,0,0]
["jasminanhydride","jasminanhydride","C523738",0,0,2,0,0,0,0]
["jatrophone","jatrophone","C006386",0,0,2,0,2,0,0]
["jesridonin","jesridonin","C000606573",0,0,2,0,6,0,0]
["Jiedu Xiaozheng Yin","Jiedu Xiaozheng Yin","C587679",0,0,10,1,6,0,0]
["JM 223","JM 223","C103115",0,0,0,0,2,0,0]
["JNJ-7706621","JNJ-7706621","C506121",0,0,2,0,4,0,0]
["jujuboside B","jujuboside B","C540008",0,0,0,0,2,0,0]
["JW55 compound","JW55 compound","C000613569",0,0,2,0,0,0,0]
["K antigens","K antigens","C030659",0,0,0,0,0,1,0]
["K99 antigen","K99 antigen","C031429",6,1,1,0,0,0,0]
["kaempferol-7-O-alpha-L-rhamnopyranoside","kaempferol-7-O-alpha-L-rhamnopyranoside","C516876",0,0,0,0,2,0,0]
["kalantubolide A","kalantubolide A","C587655",0,0,0,0,2,0,0]
["kangjia","kangjia","C545319",0,0,2,0,0,0,0]
["kartogenin","kartogenin","C572342",0,0,2,0,0,0,0]
["KB 3022","KB 3022","C064847",2,0,0,0,0,0,0]
["keramzit","keramzit","C016529",2,0,0,0,0,0,0]
["ketoprofen glucuronide","ketoprofen glucuronide","C044223",6,0,0,0,0,0,0]
["khasianine","khasianine","C110213",0,0,0,0,1,0,0]
["kinamycin C","kinamycin C","C515381",0,0,2,0,0,0,0]
["Klimadynon","Klimadynon","C584106",0,0,0,0,2,0,0]
["KNK 437","KNK 437","C410027",0,0,4,0,11,0,0]
["kollicoat MAE 30 D","kollicoat MAE 30 D","C117135",6,0,0,0,0,0,0]
["KR33426","KR33426","C569343",0,0,2,0,4,0,0]
["Kraft lignin","Kraft lignin","C076151",37,0,0,0,0,0,0]
["KSP-BCS-1alphaCHF2-1624F2-2 compound","KSP-BCS-1alphaCHF2-1624F2-2 compound","C517242",0,0,2,0,0,0,0]
["KU675 compound","KU675 compound","C000600174",0,0,2,0,0,0,0]
["Kurasper F","Kurasper F","C472990",0,0,2,0,0,0,0]
["KW 2149","KW 2149","C057625",4,0,0,0,0,0,0]
["KY88 liver-livo","KY88 liver-livo","C492792",0,0,0,0,2,0,0]
["L 345","L 345","C064071",2,0,0,0,0,0,0]
["labedipinedilol A","labedipinedilol A","C500368",0,0,4,0,6,0,0]
["Labrafil M 1944 CS","Labrafil M 1944 CS","C514708",2,0,0,0,0,0,0]
["lactosylfructoside","lactosylfructoside","C043603",2,0,0,0,0,0,0]
["laidlomycin","laidlomycin","C010208",8,0,0,0,0,0,0]
["laminarin sulfate","laminarin sulfate","C053460",0,0,2,1,2,0,0]
["Lansoprazole","Lansoprazole","D064747",113,2,14,0,8,0,0]
["LA-Plus","LA-Plus","C113097",0,0,0,0,2,0,0]
["Lasalocid","Lasalocid","D007832",48,1,4,0,2,0,0]
["laulimalide","laulimalide","C117305",0,0,15,0,4,0,0]
["laurdan","laurdan","C065580",12,0,0,0,0,0,0]
["lavender oil","lavender oil","C045718",0,0,2,0,2,0,0]
["LC15-0444","LC15-0444","C534891",0,0,2,0,8,0,0]
["leachianone G","leachianone G","C474046",2,0,0,0,0,0,0]
["leflunomide","leflunomide","C045463",2,2,41,2,46,0,0]
["lemongrass oil","lemongrass oil","C052901",0,0,0,0,2,0,0]
["Lepromin","Lepromin","D007916",0,3,0,0,0,0,0]
["leucocyanidin","leucocyanidin","C001532",2,0,0,0,0,0,0]
["leucomalachite green","leucomalachite green","C015320",14,0,2,0,1,3,0]
["levocabastine","levocabastine","C047340",0,15,2,0,2,0,0]
["lewis(a)-lewis(x)","lewis(a)-lewis(x)","C111125",0,0,0,2,0,0,0]
["LFM A13","LFM A13","C118451",0,0,2,0,6,0,0]
["licochalcone C","licochalcone C","C000600260",0,0,0,0,4,0,0]
["ligerin","ligerin","C580644",0,0,2,0,0,0,0]
["lilial","lilial","C038018",0,0,2,0,0,0,0]
["linderoline","linderoline","C571115",0,0,2,0,0,0,0]
["linolenin","linolenin","C434927",0,0,0,0,2,0,0]
["lipophosphonoglycan","lipophosphonoglycan","C008290",8,0,0,0,1,6,0]
["lipoxin A4","lipoxin A4","C040527",8,4,45,9,57,0,0]
["liriodenol","liriodenol","C000605009",0,0,2,0,0,0,0]
["lithium acetate","lithium acetate","C488804",0,1,0,0,0,0,0]
["liu-wei-di-huang wan","liu-wei-di-huang wan","C476907",0,0,5,0,2,0,0]
["lividomycin","lividomycin","C100306",4,0,0,0,0,0,0]
["lobetyolin","lobetyolin","C521561",2,0,0,0,0,0,0]
["loganic acid","loganic acid","C002947",2,0,0,0,0,0,0]
["longamide B","longamide B","C511002",0,0,2,0,0,0,0]
["Lorazepam","Lorazepam","D008140",42,5,2,0,0,0,0]
["louisianin A","louisianin A","C096930",0,0,0,1,0,0,0]
["LQFM030","LQFM030","C000618691",0,0,3,1,3,0,0]
["LU 25-109-T","LU 25-109-T","C108369",2,0,0,0,0,0,0]
["lucidenic acid B","lucidenic acid B","C527145",0,0,0,0,2,0,0]
["lumisantonin","lumisantonin","C054379",2,0,0,0,0,0,0]
["lupitidine","lupitidine","C101022",2,0,0,0,0,0,0]
["LXR 1035","LXR 1035","C403588",0,0,0,0,2,0,0]
["LY 290042","LY 290042","C549075",0,0,2,0,3,0,0]
["LY-2157299","LY-2157299","C557799",2,0,5,1,1,0,0]
["Ly-364947","Ly-364947","C520284",0,0,2,0,0,0,0]
["Lye","Lye","D008191",6,4,0,0,0,0,0]
["lysoganglioside G(M2)","lysoganglioside G(M2)","C048941",0,0,0,0,2,0,0]
["lyxose","lyxose","C043333",12,0,0,0,0,0,0]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C16772,B16772)","v":"macelignan"},"macelignan","C502026",0,0,2,0,0,0,0]
["madecassoside","madecassoside","C093443",0,0,8,0,10,0,0]
["Magnesium Chloride","Magnesium Chloride","D015636",58,2,5,0,6,0,0]
["magnesium phosphate","magnesium phosphate","C030781",32,0,17,0,0,0,0]
["magnosalin","magnosalin","C069674",0,0,0,2,0,0,0]
["Mal d 2 allergen, Malus domestica","Mal d 2 allergen, Malus domestica","C531902",2,0,0,0,0,0,0]
["maleamic acid","maleamic acid","C008311",6,0,4,0,0,0,0]
["maltitol","maltitol","C010745",14,0,0,0,0,0,0]
["maltohexaose","maltohexaose","C016549",8,0,0,0,0,0,0]
["manassantin B","manassantin B","C482885",0,0,2,0,0,0,0]
["manganese dioxide","manganese dioxide","C016552",126,2,1,1,4,0,0]
["manganese oxide","manganese oxide","C027424",221,0,9,0,9,0,0]
["manniflavanone","manniflavanone","C000606656",0,0,2,0,0,0,0]
["mannose-6-phosphate","mannose-6-phosphate","C027693",12,0,13,0,4,0,0]
["manool","manool","C482828",0,0,2,0,0,0,0]
["marchantin A","marchantin A","C096123",0,0,2,0,2,0,0]
["marinobufagenin","marinobufagenin","C093896",0,0,7,2,7,0,0]
["mastoparan Polybia-MPII, Polybia paulista","mastoparan Polybia-MPII, Polybia paulista","C550859",0,0,0,0,2,0,0]
["maytansinol","maytansinol","C562224",0,0,2,0,0,0,0]
["MC1575","MC1575","C583610",0,0,3,0,1,0,0]
["MCS-18","MCS-18","C534850",0,0,2,0,0,0,0]
["MDL 105519","MDL 105519","C101788",2,0,0,0,0,0,0]
["ME 2303","ME 2303","C059081",2,1,0,0,0,0,0]
["Meclofenamic Acid","Meclofenamic Acid","D008469",10,0,6,1,0,0,0]
["medicarpin","medicarpin","C047353",4,0,0,0,6,0,0]
["meglumine ioxithalamate","meglumine ioxithalamate","C001694",0,1,0,0,0,0,0]
["Melarsoprol","Melarsoprol","D008549",0,0,0,0,7,0,0]
["Melibiose","Melibiose","D008553",16,0,2,0,2,1,0]
["menoprogen","menoprogen","C529990",0,1,1,0,4,0,0]
["mepirodipine","mepirodipine","C050699",2,0,0,0,0,0,0]
["Mercaptoethanol","Mercaptoethanol","D008623",114,3,5,0,15,0,0]
["meriolin 3","meriolin 3","C523800",0,0,2,1,2,0,0]
["merulinic acids","merulinic acids","C018593",3,0,0,0,0,0,0]
["meso-tetra-(3-methoxyl-4-hydroxyl) phenyl manganese porphyrin","meso-tetra-(3-methoxyl-4-hydroxyl) phenyl manganese porphyrin","C571238",2,0,0,0,0,0,0]
["Mesterolone","Mesterolone","D008655",2,0,0,0,4,0,0]
["metapristone","metapristone","C000592521",0,0,8,0,2,0,0]
["methacrylated dextran","methacrylated dextran","C514458",2,0,0,0,0,0,0]
["methacryloxypropyltrimethoxysilane","methacryloxypropyltrimethoxysilane","C017492",14,0,0,0,0,0,0]
["Methandrostenolone","Methandrostenolone","D008696",2,3,0,0,0,0,0]
["Methazolamide","Methazolamide","D008704",8,0,0,0,4,0,0]
["methionol","methionol","C555618",4,0,0,0,0,0,0]
["Methoxamine","Methoxamine","D008729",21,17,0,0,0,0,0]
["Methyclothiazide","Methyclothiazide","D008736",2,0,0,0,0,0,0]
["methyl 2-(7-hydroxy-2-oxonaphtho(1,2-b)furan-3(2H)-yliden)acetate","methyl 2-(7-hydroxy-2-oxonaphtho(1,2-b)furan-3(2H)-yliden)acetate","C573736",0,0,2,0,0,0,0]
["methyl 25-hydroxy-3-oxoolean-12-en-28-oate","methyl 25-hydroxy-3-oxoolean-12-en-28-oate","C530744",0,0,9,0,10,0,0]
["methyl 2-pyridyl ketone oxime","methyl 2-pyridyl ketone oxime","C534157",2,0,0,0,0,0,0]
["methyl 3-bromo-2-methylpropanoate","methyl 3-bromo-2-methylpropanoate","C477060",0,0,0,0,0,1,0]
["methyl 6-(benzyloxycarbonylamino)-2-(2-(2,6-dioxo-3-(3,4,5-trimethoxybenzamido)piperidin-1-yl)acetamido)hexanoate","methyl 6-(benzyloxycarbonylamino)-2-(2-(2,6-dioxo-3-(3,4,5-trimethoxybenzamido)piperidin-1-yl)acetamido)hexanoate","C534400",0,0,2,0,0,0,0]
["methyl anthranilate","methyl anthranilate","C038892",2,0,0,0,0,0,0]
["methyl chlorotetrolate","methyl chlorotetrolate","C051334",4,0,0,0,0,0,0]
["methyl hydrogen fumarate","methyl hydrogen fumarate","C509058",2,0,0,0,0,0,0]
["methyl palmitate","methyl palmitate","C019012",0,1,5,0,2,0,0]
["methyl salicylate 2-O-lactoside","methyl salicylate 2-O-lactoside","C000597005",0,0,2,0,0,0,0]
["methyl thioacetate","methyl thioacetate","C026500",4,0,0,0,0,0,0]
["methylamphotericin B","methylamphotericin B","C017501",4,0,0,0,0,0,0]
["methylbenzoprim","methylbenzoprim","C064625",0,0,2,0,0,0,0]
["methylene bromide","methylene bromide","C027947",0,0,0,0,0,1,0]
["methylhydroxybenzimidate","methylhydroxybenzimidate","C014099",4,0,0,0,0,0,0]
["methylmercury II","methylmercury II","C030957",4,0,0,0,0,0,0]
["methylophiopogonanone A","methylophiopogonanone A","C543188",0,0,0,0,2,0,0]
["methylpyrrolidinone chitosan","methylpyrrolidinone chitosan","C085060",0,0,1,0,0,0,0]
["Methyltestosterone","Methyltestosterone","D008777",6,6,4,0,4,0,0]
["methyprylon","methyprylon","C084583",2,0,0,0,0,0,0]
["metsulfuron methyl","metsulfuron methyl","C050296",24,1,0,0,0,0,0]
["metylperon","metylperon","C008522",2,0,0,0,0,0,0]
["MF 438","MF 438","C548713",0,0,2,0,2,0,0]
["MI-538","MI-538","C000609009",0,0,2,0,0,0,0]
["microorganism fermentation extract","microorganism fermentation extract","C508178",0,0,4,0,4,0,0]
["miglitol","miglitol","C045621",2,0,0,0,2,0,0]
["milnacipran","milnacipran","C048107",8,0,0,0,0,0,0]
["Mirex","Mirex","D008917",2,0,0,0,2,0,0]
["Misonidazole","Misonidazole","D008920",38,7,7,12,1,0,0]
["MitoBloCK-1","MitoBloCK-1","C550341",0,0,2,0,0,0,0]
["MK 0591","MK 0591","C078266",0,0,3,0,9,1,0]
["MK-886","MK-886","C060893",4,0,9,0,50,0,0]
["MLN 944","MLN 944","C505210",0,0,2,0,0,0,0]
["MNSs Blood-Group System","MNSs Blood-Group System","D008951",36,0,0,0,0,0,0]
["moenomycin A","moenomycin A","C437243",0,0,0,0,0,1,0]
["molybdocene dichloride","molybdocene dichloride","C024389",2,0,0,0,0,0,0]
["monaphilone A","monaphilone A","C553312",0,0,2,0,1,0,0]
["mono(2-methacryloyloxy)ethyl phthalate","mono(2-methacryloyloxy)ethyl phthalate","C079977",0,0,1,0,0,0,0]
["mono-6-deoxy-6-(3R,4R-dihydroxypyrrolidine)-beta-cyclodextrin chloride","mono-6-deoxy-6-(3R,4R-dihydroxypyrrolidine)-beta-cyclodextrin chloride","C540477",2,0,0,0,0,0,0]
["monogalactosyldiacylglycerol","monogalactosyldiacylglycerol","C009909",2,0,6,0,7,0,0]
["monomethoxy poly(ethylene glycol)-block-copoly(6,14-dimethyl-1,3,9,11-tetraoxa-6,14-diazacyclohexadecane-2,10-dione-co-epsilon-caprolactone)","monomethoxy poly(ethylene glycol)-block-copoly(6,14-dimethyl-1,3,9,11-tetraoxa-6,14-diazacyclohexadecane-2,10-dione-co-epsilon-caprolactone)","C574289",2,0,0,0,0,0,0]
["mono-N-carboxymethylchitosan","mono-N-carboxymethylchitosan","C426873",4,2,0,0,0,0,0]
["monosulfuron","monosulfuron","C495688",4,0,0,0,0,0,0]
["morin","morin","C008548",28,3,30,2,40,0,0]
["morphine-3-glucuronide","morphine-3-glucuronide","C018108",6,0,0,0,0,0,0]
["motuporamine C","motuporamine C","C409085",0,0,0,1,0,0,0]
["mPEG-O-2-methylpropionaldehyde","mPEG-O-2-methylpropionaldehyde","C513579",0,0,2,1,0,0,0]
["MS023 compound","MS023 compound","C000612606",0,0,2,0,0,0,0]
["mucoid exopolysaccharide (P aeruginosa)","mucoid exopolysaccharide (P aeruginosa)","C046129",0,0,0,0,0,1,0]
["mulberrofuran F1","mulberrofuran F1","C570056",0,0,2,0,0,0,0]
["mumie","mumie","C045109",0,0,2,0,4,0,0]
["muriflasteroid A","muriflasteroid A","C581587",0,0,2,0,2,0,0]
["Muscimol","Muscimol","D009118",6,0,3,0,10,0,0]
["MX 84 ester","MX 84 ester","C114101",0,0,0,0,1,0,0]
["mycaminose","mycaminose","C013610",0,0,0,0,0,1,0]
["myriaporone 4","myriaporone 4","C505860",0,0,2,0,0,0,0]
["myrmicacin","myrmicacin","C017552",0,0,2,0,0,0,0]
["n 1 allergen, rat","n 1 allergen, rat","C472325",0,0,1,0,0,0,0]
["N-((2-chloro-6-methylquinolin-3-yl)methylene)-2-methylpropan-2-amine oxide","N-((2-chloro-6-methylquinolin-3-yl)methylene)-2-methylpropan-2-amine oxide","C570908",0,1,0,0,0,0,0]
["N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine","N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine","C570530",0,0,0,0,2,0,0]
["N-(1-(3-(3-(hydroxyamino)-3-oxoprop-1-en-1-yl)phenoxy)-3-(1H-indol-3-yl)propan-2-yl)-4-methoxybenzamide","N-(1-(3-(3-(hydroxyamino)-3-oxoprop-1-en-1-yl)phenoxy)-3-(1H-indol-3-yl)propan-2-yl)-4-methoxybenzamide","C000600800",0,0,2,0,2,0,0]
["N(1),N(3),6-trimethylcycloheptadiimidazole-2,8-diamine","N(1),N(3),6-trimethylcycloheptadiimidazole-2,8-diamine","C102665",2,0,0,0,0,0,0]
["N(1)-phenyl-N(2)-(2-pyridinylmethyl)diazenedicarboxamide","N(1)-phenyl-N(2)-(2-pyridinylmethyl)diazenedicarboxamide","C518001",0,0,0,0,2,0,0]
["N-(12-cyanoindolizino(2,3-b)quinoxalin-2-yl)thiophene-2-carboxamide","N-(12-cyanoindolizino(2,3-b)quinoxalin-2-yl)thiophene-2-carboxamide","C574708",0,0,2,0,2,0,0]
["N-(2-(1H-indazol-3-yl)-1H-pyrrole(3,2-b)pyridin-5-yl)-4-chloro-N-methylbenzamide","N-(2-(1H-indazol-3-yl)-1H-pyrrole(3,2-b)pyridin-5-yl)-4-chloro-N-methylbenzamide","C556664",0,0,0,0,2,0,0]
["N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin","N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin","C097963",0,0,2,0,0,0,0]
["N-(2-(4-o-fluorophenylpiperazin-1-yl)ethyl)-2,5-dimethyl-1 -phenylpyrrole-3,4-dicarboximide","N-(2-(4-o-fluorophenylpiperazin-1-yl)ethyl)-2,5-dimethyl-1 -phenylpyrrole-3,4-dicarboximide","C548176",2,0,0,0,0,0,0]
["N-(2-(dimethylamino)ethyl)-2,6-dimethyl-1-oxo-1,2-dihydroxybenzo(b)-1,6-naphthyridine-4-carboxamide","N-(2-(dimethylamino)ethyl)-2,6-dimethyl-1-oxo-1,2-dihydroxybenzo(b)-1,6-naphthyridine-4-carboxamide","C533598",0,0,4,0,0,0,0]
["N(2)-(2-aminocyclohexyl)-N(6)-(3-chlorophenyl)-9-ethyl-9H-purine-2,6-diamine","N(2)-(2-aminocyclohexyl)-N(6)-(3-chlorophenyl)-9-ethyl-9H-purine-2,6-diamine","C469937",0,0,0,0,7,0,0]
["N-(2,4-dimethoxyphenyl)-4-(4-methoxyphenyl)-1,3-thiazol-2-amine","N-(2,4-dimethoxyphenyl)-4-(4-methoxyphenyl)-1,3-thiazol-2-amine","C000622049",0,0,2,0,0,0,0]
["N-(2-acetamido)-2-aminoethanesulfonic acid","N-(2-acetamido)-2-aminoethanesulfonic acid","C024789",2,0,0,0,0,0,0]
["N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide","N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide","C080955",0,1,75,6,162,0,0]
["N-(2-hydroxyethyl)-N-carboxymethylnitrosamine","N-(2-hydroxyethyl)-N-carboxymethylnitrosamine","C038290",4,0,0,0,0,0,0]
["N-(2-hydroxyethyl)retinamide","N-(2-hydroxyethyl)retinamide","C022147",0,2,0,0,0,0,0]
["N-(2-thiolethyl)-2-(2-(N'-(2,6-dichlorophenyl)amino) phenyl)acetamide","N-(2-thiolethyl)-2-(2-(N'-(2,6-dichlorophenyl)amino) phenyl)acetamide","C472071",0,0,0,0,2,0,0]
["N-(3-(4,5-dihydro-1,3-thiazol-2-yl)-1,3-thiazolidin-2-ylidene)-5H-dibenzo(a,d)(7)annulen-5-amine","N-(3-(4,5-dihydro-1,3-thiazol-2-yl)-1,3-thiazolidin-2-ylidene)-5H-dibenzo(a,d)(7)annulen-5-amine","C541013",0,0,2,0,0,0,0]
["N-(3-(dimethylamino)propyl)octadecanamide","N-(3-(dimethylamino)propyl)octadecanamide","C480523",2,0,0,0,0,0,0]
["N-(3-bromophenyl)-7-methoxy-6-(3-(3-methoxypyrrolidin-1-yl)propoxy)quinazolin-4-amine","N-(3-bromophenyl)-7-methoxy-6-(3-(3-methoxypyrrolidin-1-yl)propoxy)quinazolin-4-amine","C539257",0,0,2,0,2,0,0]
["N-(3-fluoro-1-phenethylpiperidine-4-yl)-N-phenylpropionamide","N-(3-fluoro-1-phenethylpiperidine-4-yl)-N-phenylpropionamide","C000624316",2,0,0,0,0,0,0]
["N-(3-pyrene)maleimide","N-(3-pyrene)maleimide","C003944",4,0,0,0,4,1,0]
["N-(4-(2-(6-dimethylamino)benzofuranyl)phenyl)maleimide","N-(4-(2-(6-dimethylamino)benzofuranyl)phenyl)maleimide","C049623",2,0,0,0,0,0,0]
["N-(4-(4-((5-(2-methoxyethoxy)pyrazine-2-yl)thio)-2,6-dimethylphenyl)thiazol-2-yl)isonicotinamide","N-(4-(4-((5-(2-methoxyethoxy)pyrazine-2-yl)thio)-2,6-dimethylphenyl)thiazol-2-yl)isonicotinamide","C000595235",0,0,0,0,1,0,0]
["N(4)-acetylsulfaquinoxaline","N(4)-acetylsulfaquinoxaline","C044234",2,0,0,0,0,0,0]
["N(4)-hydroxycytosine","N(4)-hydroxycytosine","C021202",0,0,0,0,0,1,0]
["N-(4-bromobenzoyl)-S,S-dimethyliminosulfurane","N-(4-bromobenzoyl)-S,S-dimethyliminosulfurane","C119492",2,0,0,0,0,0,0]
["N-(4-difluoromethoxyphenyl)-N'-pinacolyl-N''-cyanoguanidine","N-(4-difluoromethoxyphenyl)-N'-pinacolyl-N''-cyanoguanidine","C559719",0,3,0,0,6,0,0]
["N-(4-hydroxybenzyl)-1,3,4-triphenyl-4,5-dihydro-1H-pyrazole-5-carboxamide","N-(4-hydroxybenzyl)-1,3,4-triphenyl-4,5-dihydro-1H-pyrazole-5-carboxamide","C000589318",0,0,4,0,2,0,0]
["N-(4-morpholinophenyl)-3-oxobenzo(d)isothiazole-2(3H)-carboxamide","N-(4-morpholinophenyl)-3-oxobenzo(d)isothiazole-2(3H)-carboxamide","C000593358",0,0,0,0,2,0,0]
["N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4-(2-oxo-1-pyrrolidinyl)phenyl)propanamide","N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4-(2-oxo-1-pyrrolidinyl)phenyl)propanamide","C500624",0,0,2,0,0,0,0]
["N-(5-dodecyl-4-hydroxytetrahydrofuran-3-yl)-2-hydroxyheptadecanamide","N-(5-dodecyl-4-hydroxytetrahydrofuran-3-yl)-2-hydroxyheptadecanamide","C527653",0,0,2,0,0,0,0]
["N-(7-(4-nitrobenzo-2-oxa-1,3-diazole))-6-aminocaproyl sphingosine","N-(7-(4-nitrobenzo-2-oxa-1,3-diazole))-6-aminocaproyl sphingosine","C037974",2,0,0,0,5,0,0]
["N-(7-nitrobenzo(c)(1,2,5)oxadiazol-4-yl)demethyltamoxifen","N-(7-nitrobenzo(c)(1,2,5)oxadiazol-4-yl)demethyltamoxifen","C000590551",0,0,1,0,0,0,0]
["N-(carboxymethyl)chitosan","N-(carboxymethyl)chitosan","C068302",4,0,2,0,0,0,0]
["N-(triethylammonium)-3-propyl(15)ane-N5","N-(triethylammonium)-3-propyl(15)ane-N5","C407019",0,0,2,0,0,0,0]
["N,1,4,4-tetramethyl-8-((4-(4-methylpiperazin-1-yl)phenyl)amino)-4,5-dihydro-1H-pyrazolo(4,3-h)quinazoline-3-carboxamide","N,1,4,4-tetramethyl-8-((4-(4-methylpiperazin-1-yl)phenyl)amino)-4,5-dihydro-1H-pyrazolo(4,3-h)quinazoline-3-carboxamide","C550092",0,0,8,0,2,0,0]
["N,N',N''-triacetylchitotriose","N,N',N''-triacetylchitotriose","C019117",8,0,1,0,0,0,0]
["N,N'-bis(2-hydroxyperoxy-2-methoxyethyl)-1,4,5,8-naphthalenetetracarboxylic diimide","N,N'-bis(2-hydroxyperoxy-2-methoxyethyl)-1,4,5,8-naphthalenetetracarboxylic diimide","C067580",0,0,0,0,0,1,0]
["N,N'-bis(dibenzyl)ethylenediaminediacetic acid","N,N'-bis(dibenzyl)ethylenediaminediacetic acid","C092592",2,0,0,0,0,0,0]
["N,N-diacetylchitobiose","N,N-diacetylchitobiose","C010913",4,0,0,0,0,1,0]
["N,N-diethyl-4-((2-(4-methoxyphenyl)-1H-indol-3-yl)methyl)aniline","N,N-diethyl-4-((2-(4-methoxyphenyl)-1H-indol-3-yl)methyl)aniline","C000594978",0,0,2,0,2,0,0]
["N,N-dimethyl-2-(2-amino-4-cyanophenylthio)benzylamine","N,N-dimethyl-2-(2-amino-4-cyanophenylthio)benzylamine","C420885",2,0,0,0,0,0,0]
["N,N-dimethylaniline","N,N-dimethylaniline","C015157",8,0,2,0,0,0,0]
["N,N-diphenylbenzamide","N,N-diphenylbenzamide","C554248",0,0,1,0,0,0,0]
["N,N'-ethylenediamine-di-(2-hidroxy-5-sulfophenylacetic) acid","N,N'-ethylenediamine-di-(2-hidroxy-5-sulfophenylacetic) acid","C501683",2,0,0,0,0,0,0]
["N1-(3-(dimethylamino)propyl)-N8-hydroxy-2-((naphthalene-1-loxy)methyl)oct-2-enediamide","N1-(3-(dimethylamino)propyl)-N8-hydroxy-2-((naphthalene-1-loxy)methyl)oct-2-enediamide","C572619",0,0,4,0,4,0,0]
["N1-(6-(3-(2-aminopyrimidin-4-yl)-1H-indol-5-yl)pyrazin-2-yl)-N2,N2-dimethylethane-1,2-diamine","N1-(6-(3-(2-aminopyrimidin-4-yl)-1H-indol-5-yl)pyrazin-2-yl)-N2,N2-dimethylethane-1,2-diamine","C000593985",0,0,2,0,0,0,0]
["N1-hydroxy-N8-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo(e)(1,4)diazepin-3-yl)octanediamide","N1-hydroxy-N8-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo(e)(1,4)diazepin-3-yl)octanediamide","C000600790",0,0,2,0,2,0,0]
["N2-(4-aminocyclohexyl)-9-cyclopentyl-N6-(6-(2-hydroxyphenyl)pyridin-3-ylmethyl)-9H-purine-2,6-diamine","N2-(4-aminocyclohexyl)-9-cyclopentyl-N6-(6-(2-hydroxyphenyl)pyridin-3-ylmethyl)-9H-purine-2,6-diamine","C584253",0,0,0,0,1,0,0]
["N-3-tolyl-4-chlorobenzohydroxamic acid","N-3-tolyl-4-chlorobenzohydroxamic acid","C044239",2,0,0,0,0,0,0]
["Na5SeV5O18","Na5SeV5O18","C517309",3,0,2,0,2,0,0]
["N-acetoxy-4-acetylaminobiphenyl","N-acetoxy-4-acetylaminobiphenyl","C022916",0,0,0,0,2,0,0]
["N-acetylcochinol-O-phosphate","N-acetylcochinol-O-phosphate","C455219",2,18,13,21,14,0,0]
["N-acetylphytosphingosine","N-acetylphytosphingosine","C511415",0,0,0,0,1,0,0]
["N-acetyl-S-(alpha-methyl-4-(2-methylpropyl)benzeneacetyl)cysteine 4-(nitrooxy)butyl ester","N-acetyl-S-(alpha-methyl-4-(2-methylpropyl)benzeneacetyl)cysteine 4-(nitrooxy)butyl ester","C488176",0,0,2,0,5,0,0]
["Nafoxidine","Nafoxidine","D009256",0,0,0,0,2,0,0]
["nalmefene","nalmefene","C038981",2,3,2,0,0,0,0]
["nanaomycin A","nanaomycin A","C008638",2,0,0,0,0,0,0]
["naoningkang","naoningkang","C533632",0,0,0,0,2,0,0]
["naphthazarin","naphthazarin","C005503",0,0,2,0,12,0,0]
["Naproxen","Naproxen","D009288",169,3,23,0,21,0,0]
["nasulysin-1, Porthidium nasutum","nasulysin-1, Porthidium nasutum","C000619000",0,0,0,0,2,0,0]
["Natamycin","Natamycin","D010866",16,0,0,0,0,1,0]
["N-benzyl-N,O-succinyl chitosan","N-benzyl-N,O-succinyl chitosan","C000600300",2,0,0,0,2,0,0]
["NB-p260 antigen","NB-p260 antigen","C120894",0,0,0,0,3,0,0]
["N-butylbenzenesulfonamide","N-butylbenzenesulfonamide","C065565",0,0,2,0,0,0,0]
["NC 174","NC 174","C083643",4,0,0,0,0,0,0]
["N-caproylsphingosine","N-caproylsphingosine","C101954",4,1,17,2,88,0,0]
["NCL-240","NCL-240","C000611383",0,0,2,0,6,0,0]
["N-cyclopropyl-4-(8-((tetrahydro-2H-pyran-4-yl)methylamino)-6-(1,1,1-trifluoro-2-methylpropan-2-ylamino)imidazo(1,2-b)pyridazin-3-yl)benzamide","N-cyclopropyl-4-(8-((tetrahydro-2H-pyran-4-yl)methylamino)-6-(1,1,1-trifluoro-2-methylpropan-2-ylamino)imidazo(1,2-b)pyridazin-3-yl)benzamide","C000597468",0,0,2,0,0,0,0]
["N-desmethylnizatidine","N-desmethylnizatidine","C066301",2,0,0,0,0,0,0]
["NE 10244","NE 10244","C108383",0,0,0,0,1,0,0]
["Necrostatin-5","Necrostatin-5","C519552",0,1,0,0,4,0,0]
["Nelfinavir","Nelfinavir","D019888",7,6,33,1,65,0,0]
["neocarzinostatin chromophore","neocarzinostatin chromophore","C032372",6,0,0,0,0,0,0]
["neoisoliquiritin","neoisoliquiritin","C098467",0,0,0,1,3,0,0]
["neosergeolide","neosergeolide","C540910",0,0,2,0,2,0,0]
["N-ethoxymethyl-3-amino-1,2,4-benzotriazine-1,4-dioxide","N-ethoxymethyl-3-amino-1,2,4-benzotriazine-1,4-dioxide","C552435",0,0,2,0,2,0,0]
["N-ethyl perfluorooctane sulfonamido acetate","N-ethyl perfluorooctane sulfonamido acetate","C542083",2,0,0,0,0,0,0]
["neurotropin","neurotropin","C010491",0,2,0,1,10,0,0]
["N-ferrocenyl-N-benzylaminocarbonyloxymethyl-phenylboronic acid pinacol ester","N-ferrocenyl-N-benzylaminocarbonyloxymethyl-phenylboronic acid pinacol ester","C000605505",0,0,0,0,2,0,0]
["NH 125","NH 125","C414024",0,0,1,0,0,0,0]
["N-hexanoyldihydrosphingosine","N-hexanoyldihydrosphingosine","C492068",0,0,2,0,2,0,0]
["N-hydroxy-4-(3-methyl-2-phenylbutyrylamino)benzamide","N-hydroxy-4-(3-methyl-2-phenylbutyrylamino)benzamide","C504522",0,0,0,0,2,0,0]
["N-hydroxyacetaminophen","N-hydroxyacetaminophen","C017372",6,0,0,0,0,0,0]
["nicotiflorin","nicotiflorin","C513882",0,0,2,0,3,0,0]
["niduloic acid","niduloic acid","C104484",0,0,0,0,1,0,0]
["nikkomycin L(x)","nikkomycin L(x)","C121128",2,0,0,0,0,0,0]
["nimbolide","nimbolide","C042198",0,0,31,3,37,0,0]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C19012,B19012)","v":"NIPAM-ODA copolymer"},"NIPAM-ODA copolymer","C112703",2,0,0,0,0,0,0]
["NISC-6","NISC-6","C000622663",0,0,2,0,2,0,0]
["nitramisole","nitramisole","C026100",2,0,0,0,0,0,0]
["nitritocobalamin","nitritocobalamin","C092105",2,0,0,0,0,0,0]
["nitroflurbiprofen","nitroflurbiprofen","C095631",0,0,0,0,6,0,0]
["nitrosobenzene","nitrosobenzene","C012456",4,0,2,0,0,0,0]
["nivalenol tetraacetate","nivalenol tetraacetate","C069217",2,0,0,0,0,0,0]
["NL-608","NL-608","C578405",0,0,2,0,2,0,0]
["N-methyl-2-(1-(3-aminopropyl)-1H-indol-3-yl)-3-(1H-indol-3-yl)maleimide","N-methyl-2-(1-(3-aminopropyl)-1H-indol-3-yl)-3-(1H-indol-3-yl)maleimide","C503756",0,1,0,0,0,0,0]
["N-methyl-5-(4'-pentylphenyl)-2-aminopent-4-ene-1,3-diol","N-methyl-5-(4'-pentylphenyl)-2-aminopent-4-ene-1,3-diol","C544832",0,0,2,1,2,0,0]
["N-methylglucosamine","N-methylglucosamine","C047635",0,0,0,0,2,0,0]
["N-methyl-N-(3-((2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino)-methyl)-pyridin-2-yl)-methanesulfonamide","N-methyl-N-(3-((2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino)-methyl)-pyridin-2-yl)-methanesulfonamide","C527797",0,0,6,2,2,0,0]
["NMS-P118","NMS-P118","C000603349",0,0,2,0,0,0,0]
["N-n-butyl haloperidol iodide","N-n-butyl haloperidol iodide","C482574",0,0,0,0,6,0,0]
["N-nitrosopropranolol","N-nitrosopropranolol","C037601",4,0,0,0,0,0,0]
["NOC 9","NOC 9","C099612",2,0,0,0,2,0,0]
["N-octyl-beta-valienamine","N-octyl-beta-valienamine","C116532",2,0,0,0,0,0,0]
["Nod factor IV, Rhizobium meliloti","Nod factor IV, Rhizobium meliloti","C092082",2,0,0,0,0,0,0]
["nonanal","nonanal","C008664",0,0,0,0,1,0,0]
["noradrenaline sulfate","noradrenaline sulfate","C017574",2,0,0,0,0,0,0]
["nordimaprit","nordimaprit","C025838",0,1,0,0,0,0,0]
["Norfloxacin","Norfloxacin","D009643",151,2,3,2,3,5,0]
["norsalsolinol","norsalsolinol","C020784",2,0,0,0,2,0,0]
["Nortriptyline","Nortriptyline","D009661",32,5,4,0,7,0,0]
["Noxythiolin","Noxythiolin","D009677",6,0,0,0,0,0,0]
["NPC 16","NPC 16","C559142",0,1,4,0,4,0,0]
["N-phenyl-N'-(3,5-dimethylpyrazol-4-yl)thiourea","N-phenyl-N'-(3,5-dimethylpyrazol-4-yl)thiourea","C490153",2,0,0,0,0,0,0]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C19332,B19332)","v":"NS 1652"},"NS 1652","C405615",2,0,0,0,0,0,0]
["NS-0011","NS-0011","C000604565",0,0,2,0,0,0,0]
["NSC 23766","NSC 23766","C487513",0,0,7,0,5,0,0]
["NSC 727447","NSC 727447","C539163",0,0,0,0,0,1,0]
["NSC666715","NSC666715","C000604551",0,0,0,0,2,0,0]
["NSI-189","NSI-189","C000620627",0,0,2,0,0,0,0]
["N-succinimidyloxycarbonylmethyl tris(2,4,6-trimethoxyphenyl)phosphonium","N-succinimidyloxycarbonylmethyl tris(2,4,6-trimethoxyphenyl)phosphonium","C000608117",2,0,0,0,0,0,0]
["N-tert-butylhydroxylamine","N-tert-butylhydroxylamine","C072771",0,0,0,0,1,0,0]
["NU 1025","NU 1025","C115774",0,0,2,0,8,0,0]
["N-vinylimidazole","N-vinylimidazole","C425704",10,0,0,0,0,0,0]
["NVP-BKM120","NVP-BKM120","C571178",0,0,43,1,47,1,0]
["O(2)-(2,4-dinitro-5-(N-methyl-N-4-carboxyphenylamino)phenyl 1-N,N-dimethylamino)diazen-1-ium-1,2-diolate","O(2)-(2,4-dinitro-5-(N-methyl-N-4-carboxyphenylamino)phenyl 1-N,N-dimethylamino)diazen-1-ium-1,2-diolate","C485370",0,0,2,0,0,0,0]
["O-(fluoresceinylmethyl)hydroxylamine","O-(fluoresceinylmethyl)hydroxylamine","C118023",2,0,0,0,0,0,0]
["O2-(2,4-dinitro-5-((2-(12-en-28-galactopyranosyloleanolate-3-yl)oxy-2-oxoethyl)amino)phenyl) 1-(N-hydroxyethylmethylamino)diazen-1-ium-1,2-diolate","O2-(2,4-dinitro-5-((2-(12-en-28-galactopyranosyloleanolate-3-yl)oxy-2-oxoethyl)amino)phenyl) 1-(N-hydroxyethylmethylamino)diazen-1-ium-1,2-diolate","C576900",0,0,4,0,4,0,0]
["oakmoss","oakmoss","C044724",0,0,1,0,0,0,0]
["Obidoxime Chloride","Obidoxime Chloride","D009768",8,0,0,0,0,0,0]
["ochratoxin B","ochratoxin B","C045354",2,0,2,0,0,0,0]
["octabromotetrakis(4-methylpyridyl)porphine","octabromotetrakis(4-methylpyridyl)porphine","C000588762",2,0,0,0,0,0,0]
["octadecyl polyoxyethylene ether","octadecyl polyoxyethylene ether","C043444",4,0,0,0,0,0,0]
["octapinol","octapinol","C039611",2,0,1,0,0,0,0]
["octyl-2-sulfate","octyl-2-sulfate","C034597",2,0,0,0,0,0,0]
["odapipam","odapipam","C075357",2,0,0,0,0,0,0]
["OKN 007","OKN 007","C552724",0,1,7,1,5,0,0]
["oleifolioside A","oleifolioside A","C546794",0,0,0,0,2,0,0]
["oleoylsphingosine","oleoylsphingosine","C031412",2,0,0,0,0,0,0]
["oligochitosan","oligochitosan","C493484",16,0,6,0,5,0,0]
["olsalazine","olsalazine","C032587",10,0,0,0,2,0,0]
["OMDM-2 cpd","OMDM-2 cpd","C474343",0,0,2,0,0,0,0]
["omtriptolide","omtriptolide","C417603",0,0,2,0,2,0,0]
["oncocalyxone A","oncocalyxone A","C408504",0,0,1,0,2,0,0]
["ONO 6240","ONO 6240","C048549",0,1,0,0,0,0,0]
["Onyx copolymer","Onyx copolymer","C450660",0,3,0,4,0,0,0]
["ophiopogonin D","ophiopogonin D","C046996",0,0,4,0,6,0,0]
["OptiBond SOLO","OptiBond SOLO","C428805",0,0,0,0,2,0,0]
["orange oil","orange oil","C087245",10,0,2,0,0,0,0]
["oridonin","oridonin","C011959",6,3,162,2,270,0,0]
["orteronel","orteronel","C571806",0,0,2,0,0,0,0]
["osmium ammine B","osmium ammine B","C058639",2,0,0,0,0,0,0]
["OSU-2S","OSU-2S","C560545",0,0,2,0,2,0,0]
["ottelione A","ottelione A","C468748",0,0,4,0,2,0,0]
["oval cell marker OV-6","oval cell marker OV-6","C115011",0,1,0,0,0,0,0]
["oxalomalic acid","oxalomalic acid","C015407",0,0,2,0,5,0,0]
["Oxazolone","Oxazolone","D010081",6,1,10,1,0,2,0]
["oxetane","oxetane","C005287",2,0,0,0,0,0,0]
["oxovanadium IV","oxovanadium IV","C075743",16,0,18,0,15,0,0]
["oxyhyponitrite","oxyhyponitrite","C021229",8,0,0,0,0,0,0]
["oxypropanolamine","oxypropanolamine","C507551",0,0,2,0,0,0,0]
["P2-246-259","P2-246-259","C501564",0,1,0,0,0,0,0]
["PA024 compound","PA024 compound","C000608768",0,0,4,0,4,0,0]
["Pactamycin","Pactamycin","D010142",2,0,2,0,2,0,0]
["paederosidic acid","paederosidic acid","C000588809",0,0,0,0,2,0,0]
["palladium-meso-tetra(4-carboxyphenyl)porphine","palladium-meso-tetra(4-carboxyphenyl)porphine","C079625",6,0,0,0,0,0,0]
["pamabrom","pamabrom","C069987",2,0,0,0,0,0,0]
["Panavia TPN-S","Panavia TPN-S","C093719",2,0,0,0,0,0,0]
["panenza vaccine","panenza vaccine","C560398",0,0,2,0,2,0,0]
["panobinostat","panobinostat","C496932",0,1,126,3,164,0,0]
["papulacandin B","papulacandin B","C020789",0,0,0,0,0,2,0]
["Paramethasone","Paramethasone","D010248",0,4,0,0,0,0,0]
["paratocarpin E","paratocarpin E","C000620935",0,0,2,0,2,0,0]
["parylene","parylene","C011055",6,0,16,0,0,0,0]
["paucinervin D","paucinervin D","C553480",0,0,0,0,2,0,0]
["PB28 compound","PB28 compound","C513937",0,0,4,0,3,0,0]
["p-carboxymethylphenyl 1,1-bis(3'-indolyl)-1-(p-carboxymethylphenyl)methane","p-carboxymethylphenyl 1,1-bis(3'-indolyl)-1-(p-carboxymethylphenyl)methane","C000610380",0,0,2,0,0,0,0]
["PCNT13","PCNT13","C000621057",0,0,0,0,2,0,0]
["PD 173074","PD 173074","C115711",0,0,26,0,20,1,0]
["p-Dimethylaminoazobenzene","p-Dimethylaminoazobenzene","D004124",42,3,1,0,0,1,0]
["pectenotoxin 2","pectenotoxin 2","C098380",2,0,7,0,10,0,0]
["pegylated zinc protoporphyrin","pegylated zinc protoporphyrin","C476103",0,0,2,0,5,0,0]
["penethamate hydroiodide","penethamate hydroiodide","C008780",4,0,0,0,0,0,0]
["penicillenone","penicillenone","C530588",0,0,2,0,0,0,0]
["pentachlorobenzene","pentachlorobenzene","C003060",2,0,0,0,0,0,0]
["pentaethylene glycol monododecyl ether","pentaethylene glycol monododecyl ether","C077053",2,0,0,0,0,0,0]
["pentamer formyl thiophene acetic acid","pentamer formyl thiophene acetic acid","C572917",2,0,0,0,0,0,0]
["pentyl 4-(N-doxazolidinylcarbonyloxymethyl)phenylcarbamate","pentyl 4-(N-doxazolidinylcarbonyloxymethyl)phenylcarbamate","C517056",0,0,2,0,0,0,0]
["peperomin E","peperomin E","C545363",0,0,2,0,4,0,0]
["perfloxacin","perfloxacin","C077130",2,0,0,0,0,0,0]
["perfluorooctane","perfluorooctane","C073608",0,0,6,0,0,0,0]
["perhydroxyl radical","perhydroxyl radical","C049375",26,1,1,0,3,4,0]
["perillic acid","perillic acid","C078706",2,0,2,0,5,0,0]
["Perlan Blue","Perlan Blue","C029678",0,1,0,0,0,0,0]
["peroxyoxalate","peroxyoxalate","C044622",12,0,0,0,0,0,0]
["perylene bisimide","perylene bisimide","C510697",6,0,1,0,0,0,0]
["petunidin-3-glucoside","petunidin-3-glucoside","C455107",0,0,0,0,2,0,0]
["PF-05089771","PF-05089771","C000618268",2,0,0,0,0,0,0]
["phaseollin (isoflavan)","phaseollin (isoflavan)","C053345",0,1,2,0,2,0,0]
["phenacyl bromide","phenacyl bromide","C013190",2,0,0,0,0,0,0]
["Phencyclidine","Phencyclidine","D010622",62,4,8,0,36,1,0]
["Pheniramine","Pheniramine","D010632",4,1,0,0,4,0,0]
["phenothiazine","phenothiazine","C031637",20,1,8,0,13,0,0]
["Phentermine","Phentermine","D010645",12,1,2,0,0,0,0]
["phenyl vinyl ether","phenyl vinyl ether","C096130",2,0,0,0,0,0,0]
["phenylacetic acid","phenylacetic acid","C025136",24,0,5,0,22,1,0]
["phenylmercuric nitrate, basic","phenylmercuric nitrate, basic","C008860",2,0,0,0,0,0,0]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C20420,B20420)","v":"phenylsulfate"},"phenylsulfate","C025208",0,0,0,0,2,0,0]
["phidianidine B","phidianidine B","C559225",0,0,2,0,0,0,0]
["pholcodine","pholcodine","C008872",4,0,0,0,0,0,0]
["phorbaside B","phorbaside B","C520583",0,0,2,0,0,0,0]
["phorbolol myristate acetate","phorbolol myristate acetate","C016658",0,0,6,0,9,0,0]
["phosphatidylcholine hydroperoxide","phosphatidylcholine hydroperoxide","C057590",8,0,0,0,1,0,0]
["phosphatidylinositol 3-phosphate","phosphatidylinositol 3-phosphate","C055525",4,0,2,0,4,1,0]
["phosphomannopentaose sulfate","phosphomannopentaose sulfate","C120158",2,0,2,3,2,0,0]
["phosphoramide","phosphoramide","C005438",2,0,0,0,0,0,0]
["photobilirubin","photobilirubin","C028529",2,0,0,0,0,0,0]
["phthalocyanine Pc 4","phthalocyanine Pc 4","C107448",0,0,0,0,35,0,0]
["p-Hydroxynorephedrine","p-Hydroxynorephedrine","D010137",0,0,0,0,2,0,0]
["physapubenolide","physapubenolide","C000623234",0,0,4,0,4,0,0]
["physostigmine heptyl","physostigmine heptyl","C052450",6,0,0,0,0,0,0]
["phytomonic acid","phytomonic acid","C028716",2,0,0,0,0,0,0]
["picosulfate sodium","picosulfate sodium","C005701",7,0,0,0,0,0,0]
["pierreione B","pierreione B","C584582",0,0,0,0,2,0,0]
["pillar(6)arene","pillar(6)arene","C581440",8,0,4,0,2,0,0]
["pimaric acid","pimaric acid","C008911",0,0,2,0,0,0,0]
["pinocembrin","pinocembrin","C016063",2,1,2,0,22,0,0]
["pioloform","pioloform","C036549",2,0,0,0,0,0,0]
["piperazinomethyl polystyrene","piperazinomethyl polystyrene","C520893",2,0,0,0,0,0,0]
["piplartine","piplartine","C479506",0,1,4,0,8,0,0]
["pirinixil","pirinixil","C016908",0,0,0,0,1,0,0]
["pirprofen","pirprofen","C008924",4,1,0,0,0,0,0]
["pivalyloxymethyl butyrate","pivalyloxymethyl butyrate","C070441",0,0,4,1,8,0,0]
["PKH67","PKH67","C451241",0,0,3,0,1,0,0]
["plancitoxin I, Acanthaster planci","plancitoxin I, Acanthaster planci","C000602793",0,0,2,0,2,0,0]
["plastochromanol 8","plastochromanol 8","C013649",2,0,82,3,102,0,0]
["platinum basic fuchsin complex","platinum basic fuchsin complex","C065097",2,0,0,0,0,0,0]
["platinum(II) tetrachlorodianion (Fast Black)2","platinum(II) tetrachlorodianion (Fast Black)2","C060457",2,0,0,0,0,0,0]
["plukenetione A","plukenetione A","C534123",0,0,2,0,0,0,0]
["PMS 777","PMS 777","C507206",0,0,0,0,4,0,0]
["PNU-282987","PNU-282987","C498513",0,0,0,0,10,0,0]
["policosanol","policosanol","C080710",2,1,0,0,2,0,0]
["poly((3,3''-di(S)-5-amino-5-carbonyl-3-oxapentyl)-(2,2'-5',2''))-5,5''-terthiophenylene hydrochloride","poly((3,3''-di(S)-5-amino-5-carbonyl-3-oxapentyl)-(2,2'-5',2''))-5,5''-terthiophenylene hydrochloride","C499361",2,0,0,0,0,0,0]
["poly(1,3-phenylenediamine)","poly(1,3-phenylenediamine)","C435915",8,0,0,0,0,0,0]
["poly(2-(3-thienyl)ethyloxy-4-butylsulfonate)","poly(2-(3-thienyl)ethyloxy-4-butylsulfonate)","C551285",2,0,0,0,0,0,0]
["poly(2-acrylamido-2-methyl-1-propanesulfonic acid)","poly(2-acrylamido-2-methyl-1-propanesulfonic acid)","C077118",14,0,4,0,0,0,0]
["poly(2-hydroxy-1-(2-hydroxy-4-sulfo-1-napthylazo)-3-naphthoic acid)","poly(2-hydroxy-1-(2-hydroxy-4-sulfo-1-napthylazo)-3-naphthoic acid)","C580937",2,0,0,0,0,0,0]
["poly(3-(3,4-dihydroxyphenyl)glyceric acid)","poly(3-(3,4-dihydroxyphenyl)glyceric acid)","C525096",0,0,0,0,2,0,0]
["poly(3-hydroxybutyrate)-co-(3-hydroxyvalerate)","poly(3-hydroxybutyrate)-co-(3-hydroxyvalerate)","C052620",40,1,68,0,7,0,0]
["poly(4-hydroxybutanoate)","poly(4-hydroxybutanoate)","C107955",6,0,2,0,2,0,0]
["poly(6-aminohexyl propylene phosphate)","poly(6-aminohexyl propylene phosphate)","C508217",0,0,2,0,0,0,0]
["poly(acrylic acid-co-acrylamido-2-methyl-1-propanesulfonic acid)-graft-poly(N,N-dimethylacrylamide)","poly(acrylic acid-co-acrylamido-2-methyl-1-propanesulfonic acid)-graft-poly(N,N-dimethylacrylamide)","C522817",2,0,0,0,0,0,0]
["poly(aniline-co-o-aminophenol)","poly(aniline-co-o-aminophenol)","C522165",4,0,0,0,0,0,0]
["poly(butyl methacrylate-co-ethylene dimethacrylate-co-(2-(methacryloyloxy)ethyl)trimethylammonium chloride)","poly(butyl methacrylate-co-ethylene dimethacrylate-co-(2-(methacryloyloxy)ethyl)trimethylammonium chloride)","C550992",2,0,0,0,0,0,0]
["poly(D,L-lactide)-g-poly(N-isopropyl acrylamide-co-methacrylic acid)","poly(D,L-lactide)-g-poly(N-isopropyl acrylamide-co-methacrylic acid)","C503833",2,0,0,0,0,0,0]
["poly(epsilon-caprolactone-co-lactide)-poly(ethylene glycol)","poly(epsilon-caprolactone-co-lactide)-poly(ethylene glycol)","C512884",6,0,0,0,0,0,0]
["poly(ethylene glycol) methacrylate polymer","poly(ethylene glycol) methacrylate polymer","C450003",4,0,1,0,0,0,0]
["poly(ethylene glycol)-poly(caprolactone)-poly(ethylene glycol)","poly(ethylene glycol)-poly(caprolactone)-poly(ethylene glycol)","C502908",2,0,1,0,0,0,0]
["poly(ethylene oxide)-poly(3-hydroxybutyrate)-poly(ethylene oxide)","poly(ethylene oxide)-poly(3-hydroxybutyrate)-poly(ethylene oxide)","C512724",0,0,0,0,1,0,0]
["poly(glycerol-dodecanoate)","poly(glycerol-dodecanoate)","C547113",0,0,4,0,0,0,0]
["poly(hydroxyethyl methacrylate-co-poly(ethylene glycol)-methacrylate)","poly(hydroxyethyl methacrylate-co-poly(ethylene glycol)-methacrylate)","C533029",2,0,0,0,0,0,0]
["poly(lactic acid-co-epsilon-caprolactone)","poly(lactic acid-co-epsilon-caprolactone)","C550605",2,0,32,0,0,0,0]
["poly(lactide-co-6-methyl-2,5-morpholinedione)","poly(lactide-co-6-methyl-2,5-morpholinedione)","C118769",2,0,0,0,0,0,0]
["poly(methacrylic acid-ethylene glycol)","poly(methacrylic acid-ethylene glycol)","C099679",18,0,0,0,0,0,0]
["poly(methyloctylsiloxane)","poly(methyloctylsiloxane)","C475630",2,0,0,0,0,0,0]
["poly(N,N-cystaminebis(acrylamide(2)-4-(aminomethyl)piperidine)-polyethylene glycol","poly(N,N-cystaminebis(acrylamide(2)-4-(aminomethyl)piperidine)-polyethylene glycol","C000612522",2,0,0,0,0,0,0]
["poly(N-isopropylacrylamide)-dextran-maleic acid","poly(N-isopropylacrylamide)-dextran-maleic acid","C523567",2,0,0,0,0,0,0]
["poly(N-isopropylacrylamide-co-propylacrylic acid)","poly(N-isopropylacrylamide-co-propylacrylic acid)","C512582",6,0,0,0,0,0,0]
["poly(octadecanoic anhydride)","poly(octadecanoic anhydride)","C529486",2,0,0,0,0,0,0]
["poly(phenylacetylene)","poly(phenylacetylene)","C519145",0,0,0,0,2,0,0]
["poly(sodium styrenesulfonate-co-2-vinylnaphthalene)","poly(sodium styrenesulfonate-co-2-vinylnaphthalene)","C403056",2,0,0,0,0,0,0]
["poly(tetrahydrofuran)","poly(tetrahydrofuran)","C524501",2,0,0,0,0,0,0]
["poly(trimellitylimido-tyrosine-co-sebacic acid-co-1,3-bis(carboxyphemoxy)propane) anhydride","poly(trimellitylimido-tyrosine-co-sebacic acid-co-1,3-bis(carboxyphemoxy)propane) anhydride","C114275",2,0,0,0,0,0,0]
["polyamic acid","polyamic acid","C513053",5,0,1,0,0,0,0]
["poly-beta-hydroxybutyrate","poly-beta-hydroxybutyrate","C003182",120,1,41,0,2,6,0]
["polycarbonate","polycarbonate","C005506",32,0,23,0,4,0,0]
["polydiisopropyl fumarate","polydiisopropyl fumarate","C560929",0,0,2,0,0,0,0]
["polyetherurethane urea","polyetherurethane urea","C044690",4,0,5,0,2,0,0]
["polyethylene glycol-poly(lactic-co-glycolic acid)-polyethylene glycol","polyethylene glycol-poly(lactic-co-glycolic acid)-polyethylene glycol","C520330",2,0,0,0,0,0,0]
["polyglyceryl-6-dioleate","polyglyceryl-6-dioleate","C480531",2,0,0,0,0,0,0]
["polyglycerylmethacrylate","polyglycerylmethacrylate","C009932",2,1,0,0,0,0,0]
["polyisobutyl cyanoacrylate","polyisobutyl cyanoacrylate","C049456",16,0,0,0,0,0,0]
["polymethylhydrosiloxane","polymethylhydrosiloxane","C408752",2,0,0,0,0,0,0]
["polyoxydine","polyoxydine","C081207",6,0,0,0,0,0,0]
["polyoxypropyleneamine","polyoxypropyleneamine","C064807",2,0,0,0,0,0,0]
["polyprenylpyrophosphate","polyprenylpyrophosphate","C008981",2,0,0,0,0,0,0]
["polysaccharide b, Bletilla striata","polysaccharide b, Bletilla striata","C000591471",0,0,2,0,2,0,0]
["polyterephthalic acid anhydride","polyterephthalic acid anhydride","C045870",4,0,0,0,0,0,0]
["polythionates","polythionates","C026265",10,0,0,0,0,0,0]
["polyvinylmethylsiloxanediol","polyvinylmethylsiloxanediol","C085317",2,0,0,0,0,0,0]
["ponceau 6R","ponceau 6R","C017664",2,0,0,0,0,0,0]
["Porphobilinogen","Porphobilinogen","D011162",26,0,0,0,8,1,0]
["potassium cardioplegic solution","potassium cardioplegic solution","C018369",25,3,0,0,6,0,0]
["potassium metabisulfite","potassium metabisulfite","C005199",2,0,1,0,0,0,0]
["potassium persulfate","potassium persulfate","C009007",47,0,0,0,0,0,0]
["pradimicin FA 2","pradimicin FA 2","C066544",0,0,0,0,1,0,0]
["praeruptorin A","praeruptorin A","C441070",2,0,5,0,0,0,0]
["prednisolone acetate","prednisolone acetate","C009935",5,2,0,2,0,0,0]
["prenol","prenol","C009034",2,0,0,0,0,0,0]
["Primaquine","Primaquine","D011319",38,0,6,0,6,0,0]
["pristanic acid","pristanic acid","C002844",2,0,0,0,0,0,0]
["Probenecid","Probenecid","D011339",65,1,2,0,4,0,0]
["procion green H-E4BD","procion green H-E4BD","C026268",0,0,0,0,0,1,0]
["pro-F-EGCG2","pro-F-EGCG2","C548750",0,0,0,0,2,0,0]
["profenamine","profenamine","C084820",4,2,2,0,0,0,0]
["ProOsteon","ProOsteon","C000591213",0,1,2,0,0,0,0]
["propargyl ether","propargyl ether","C531209",0,0,2,0,0,0,0]
["propazine","propazine","C100043",2,0,0,0,0,0,0]
["propionylcholine","propionylcholine","C009062",2,0,0,0,0,0,0]
["propyl 4-(2-(4,6-dimethoxypyrimidin-2-yloxy)benzylamino)benzoate","propyl 4-(2-(4,6-dimethoxypyrimidin-2-yloxy)benzylamino)benzoate","C543844",10,0,0,0,0,0,0]
["propylene-1,2-diaminotetraacetic acid-ruthenium(III) complex","propylene-1,2-diaminotetraacetic acid-ruthenium(III) complex","C109683",2,0,0,0,0,0,0]
["prostaglandin B2","prostaglandin B2","C042026",0,0,1,0,0,0,0]
["prostaglandin E3","prostaglandin E3","C033246",0,0,7,1,2,0,0]
["protect bond primer","protect bond primer","C513790",2,0,0,0,0,0,0]
["prothioconazole","prothioconazole","C550005",0,0,2,0,0,0,0]
["protosappanin A","protosappanin A","C090723",0,0,1,0,0,0,0]
["proxigermanium","proxigermanium","C066750",2,0,2,0,1,0,0]
["prucalopride","prucalopride","C406662",2,0,0,0,1,0,0]
["Pseudoephedrine","Pseudoephedrine","D054199",18,1,0,0,2,0,0]
["psilostachyin C","psilostachyin C","C560366",0,0,2,0,4,0,0]
["psoralidin","psoralidin","C102768",0,0,9,0,12,0,0]
["PTC-209","PTC-209","C586999",0,0,6,0,6,0,0]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C21764,B21764)","v":"p-tert-butyl catechol"},"p-tert-butyl catechol","C015047",2,0,0,0,0,0,0]
["pullulan","pullulan","C009109",92,1,19,0,4,2,0]
["purfalcamine","purfalcamine","C531239",0,0,2,0,0,0,0]
["Putrescine","Putrescine","D011700",102,9,41,2,51,1,0]
["pyracarbolid","pyracarbolid","C012522",0,0,2,0,0,0,0]
["pyrazolo(3,4-d)pyridazin","pyrazolo(3,4-d)pyridazin","C502763",0,0,2,0,2,0,0]
["pyrazolo(3,4-d)pyrimidine","pyrazolo(3,4-d)pyrimidine","C014175",0,0,28,0,8,0,0]
["Pyridinolcarbamate","Pyridinolcarbamate","D011727",0,3,0,0,0,0,0]
["pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid","pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid","C077792",10,2,0,0,7,0,0]
["pyridyldithiopropionoylamino-poly(ethylene glycol)-distearoylphosphatidylethanolamine","pyridyldithiopropionoylamino-poly(ethylene glycol)-distearoylphosphatidylethanolamine","C095031",0,0,0,0,1,0,0]
["pyrindamycin A","pyrindamycin A","C057900",2,0,2,0,0,0,0]
["pyrogallol sulfonphthalein","pyrogallol sulfonphthalein","C058731",8,0,0,0,0,0,0]
["pyrrocidine A","pyrrocidine A","C508751",0,0,0,0,2,0,0]
["pyrrolo(1,2-a)quinoxaline","pyrrolo(1,2-a)quinoxaline","C531444",0,0,2,0,0,0,0]
["pyrrolo-cytosine","pyrrolo-cytosine","C571245",2,0,0,0,0,0,0]
["qianliening","qianliening","C579120",0,0,8,0,8,0,0]
["Quartz","Quartz","D011791",103,0,15,0,14,0,0]
["quercetin 3-O-methyl ether","quercetin 3-O-methyl ether","C459210",0,0,4,0,6,0,0]
["qufeng zhidong","qufeng zhidong","C545315",0,0,2,0,0,0,0]
["quinaldine blue","quinaldine blue","C019071",4,0,0,0,0,0,0]
["quinethazone","quinethazone","C050700",0,0,0,0,0,1,0]
["Quinolinic Acid","Quinolinic Acid","D017378",12,17,5,0,35,0,0]
["quintozene","quintozene","C005805",4,0,0,0,0,0,0]
["R 66703","R 66703","C060692",2,0,0,0,0,0,0]
["rabdocoetsin B","rabdocoetsin B","C557752",0,0,0,0,2,0,0]
["rac-glycerol 1-monodecanoate","rac-glycerol 1-monodecanoate","C004204",8,0,0,0,0,0,0]
["radolmidine","radolmidine","C400294",2,0,0,0,0,0,0]
["Raltegravir Potassium","Raltegravir Potassium","D000068898",4,0,4,0,3,1,0]
["raptinal","raptinal","C000611311",0,0,0,0,2,0,0]
["razaxaban","razaxaban","C500057",2,0,0,0,0,0,0]
["Re 80","Re 80","C085268",0,0,0,1,0,0,0]
["reactive red 120 dye","reactive red 120 dye","C042516",22,0,0,0,0,0,0]
["Reamberin","Reamberin","C549374",9,1,0,0,0,0,0]
["recoflavone","recoflavone","C121889",0,0,5,0,2,0,0]
["reevesioside F","reevesioside F","C585486",2,0,3,0,4,0,0]
["Reinecke Salt","Reinecke Salt","C001818",4,0,0,0,0,0,0]
["Remaxol","Remaxol","C555877",0,0,0,0,2,0,0]
["renzapride","renzapride","C053006",2,0,0,0,0,0,0]
["resilon sealer","resilon sealer","C486892",2,0,2,0,0,0,0]
["resorufin","resorufin","C014180",10,0,5,0,2,1,0]
["retinol palmitate","retinol palmitate","C014794",12,1,2,8,3,0,0]
["retinylidene dimedone","retinylidene dimedone","C023048",0,0,0,4,0,0,0]
["rhamnan","rhamnan","C065836",0,0,2,0,0,1,0]
["Rhamnose","Rhamnose","D012210",66,1,8,0,17,1,0]
["rhenanite","rhenanite","C076375",2,0,0,0,0,0,0]
["rhinopront syrup","rhinopront syrup","C093377",0,2,0,0,0,0,0]
["rhodac","rhodac","C437344",0,0,0,0,2,0,0]
["rhododendrol","rhododendrol","C115945",0,1,4,0,4,0,0]
["ribociclib","ribociclib","C000589651",0,0,10,0,8,0,0]
["ridaifen-B","ridaifen-B","C528171",0,0,0,0,1,0,0]
["rilmazafone","rilmazafone","C041075",2,0,0,0,0,0,0]
["rimcazole","rimcazole","C034931",0,0,2,0,1,0,0]
["ritetronium","ritetronium","C012121",0,0,3,0,0,0,0]
["RK-33 compound","RK-33 compound","C000603512",0,0,2,0,1,0,0]
["Ro 13-3978","Ro 13-3978","C000591057",0,0,2,0,0,0,0]
["Ro 25-6760","Ro 25-6760","C113532",0,0,0,0,3,0,0]
["Robenidine","Robenidine","D012370",2,0,0,0,0,0,0]
["roeko seal","roeko seal","C465381",0,0,2,0,0,0,0]
["Rolipram","Rolipram","D020889",2,4,12,3,23,0,0]
["rosbin","rosbin","C000613751",0,0,0,0,2,0,0]
["RotaTeq","RotaTeq","C492535",0,0,0,0,0,1,0]
["Roussin's Black Salt","Roussin's Black Salt","C078952",0,0,0,0,2,0,0]
["RPI-1 compound","RPI-1 compound","C477359",0,0,0,1,2,0,0]
["RS66 alloy","RS66 alloy","C588231",0,0,2,0,0,0,0]
["RTI 3021-012","RTI 3021-012","C117799",0,0,0,0,2,0,0]
["rubropunctatin","rubropunctatin","C556146",0,0,2,0,3,0,0]
["ruthenium chloride","ruthenium chloride","C038365",0,0,2,0,0,0,0]
["ruthenium(2-(4-(pyridin-2-yl)phenyl)-1H-imidazo(4,5-f)(1,10)phenanthroline)","ruthenium(2-(4-(pyridin-2-yl)phenyl)-1H-imidazo(4,5-f)(1,10)phenanthroline)","C560355",2,0,0,0,0,0,0]
["S 12340","S 12340","C085571",0,1,0,0,0,0,0]
["S 2242","S 2242","C092709",0,1,0,0,0,0,0]
["S,S,S-tris(2-ethylhexyl) phosphorotrithioate","S,S,S-tris(2-ethylhexyl) phosphorotrithioate","C520219",2,0,0,0,0,0,0]
["S30972-1","S30972-1","C418862",0,0,0,0,2,0,0]
["safingol","safingol","C005682",12,4,3,0,78,1,0]
["sairei-to","sairei-to","C080903",0,0,5,1,2,0,0]
["sakuranetin","sakuranetin","C099724",0,0,3,0,0,0,0]
["salicylamide","salicylamide","C031060",8,0,4,0,0,0,0]
["Saliva, Artificial","Saliva, Artificial","D012464",123,1,2,0,0,0,0]
["salonitenolide","salonitenolide","C011103",0,0,2,0,0,0,0]
["salternamide A","salternamide A","C000600890",0,0,0,0,2,0,0]
["salvinorin A","salvinorin A","C090499",0,0,2,0,0,1,0]
["sann-joong-kuey-jian-tang","sann-joong-kuey-jian-tang","C584126",0,0,2,0,4,0,0]
["sappanone A","sappanone A","C000601074",0,0,2,0,0,0,0]
["SAR405","SAR405","C000594652",0,0,4,0,0,0,0]
["sarcodonin G","sarcodonin G","C410409",0,0,2,0,2,0,0]
["satavaptan","satavaptan","C103281",0,0,0,0,2,1,0]
["satratoxin H","satratoxin H","C014184",0,0,0,0,5,0,0]
["saxifragifolin B","saxifragifolin B","C523878",0,0,1,0,1,0,0]
["SB-559457","SB-559457","C546477",0,0,2,0,0,0,0]
["SBI-0640756","SBI-0640756","C000607014",0,0,2,0,0,0,0]
["SC-2001","SC-2001","C572884",0,0,1,0,8,0,0]
["SC-alphaalphadelta9","SC-alphaalphadelta9","C115707",0,0,0,0,2,0,0]
["Sch 29482","Sch 29482","C033922",2,0,0,0,0,0,0]
["schiartane","schiartane","C512130",0,0,2,0,2,0,0]
["schizandrin","schizandrin","C011105",0,0,6,0,16,0,0]
["sclerotiorin","sclerotiorin","C101449",0,0,1,0,2,0,0]
["scoparone","scoparone","C018145",2,0,14,0,0,0,0]
["scyphostatin","scyphostatin","C121123",0,0,0,0,2,0,0]
["sea nettle toxin","sea nettle toxin","C031441",2,0,0,0,2,0,0]
["secoisolariciresinol diglucoside","secoisolariciresinol diglucoside","C090142",6,0,7,0,11,0,0]
["Selegiline","Selegiline","D012642",18,0,8,0,90,0,0]
["Self Cure adhesive","Self Cure adhesive","C474194",4,0,0,0,0,0,0]
["Semaxinib","Semaxinib","C116890",2,4,30,28,38,0,0]
["sensitin","sensitin","C012031",2,0,0,0,0,0,0]
["sepiapterin","sepiapterin","C016727",2,0,2,0,8,1,0]
["sesaminol","sesaminol","C066016",0,0,0,0,10,0,0]
["SH003 extract","SH003 extract","C000613735",0,0,6,1,7,0,0]
["shemamruthaa","shemamruthaa","C000588470",0,0,2,0,4,0,0]
["shenqui-wan","shenqui-wan","C484999",0,0,0,0,2,0,0]
["shimotsu-to","shimotsu-to","C079710",0,0,0,1,2,0,0]
["shosaiko-to","shosaiko-to","C461320",0,1,6,0,10,0,0]
["sialyl Le(a) ganglioside","sialyl Le(a) ganglioside","C064564",0,0,0,2,1,0,0]
["sialyl-Le(a) oligosaccharide","sialyl-Le(a) oligosaccharide","C058981",0,0,0,0,0,1,0]
["silicon nitride","silicon nitride","C032734",16,0,7,0,0,0,0]
["silver chloride","silver chloride","C037548",32,0,0,0,2,0,0]
["silydianin","silydianin","C015505",2,0,0,0,2,0,0]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C23108,B23108)","v":"Simulgel A"},"Simulgel A","C480768",2,0,0,0,0,0,0]
["sinapinic acid","sinapinic acid","C073734",10,0,6,0,8,0,0]
["sintokamide C","sintokamide C","C549486",0,0,2,0,0,0,0]
["Sirolimus","Sirolimus","D020123",38,34,1359,94,898,11,0]
["SJ 172550","SJ 172550","C549331",0,0,2,0,2,0,0]
["SK-7041","SK-7041","C497103",0,0,6,0,6,0,0]
["SL11144","SL11144","C483830",0,0,0,0,1,0,0]
["SM-1 compound","SM-1 compound","C000619853",0,0,0,0,2,0,0]
["S-methyl-N,N-diethyldithiocarbamoyl sulfoxide","S-methyl-N,N-diethyldithiocarbamoyl sulfoxide","C557567",0,0,0,0,2,0,0]
["SNS 314","SNS 314","C532454",0,0,8,0,4,0,0]
["sodium 1,2-naphthoquine-4-sulfonate","sodium 1,2-naphthoquine-4-sulfonate","C533173",2,0,0,0,0,0,0]
["sodium bisulfide","sodium bisulfide","C025451",10,0,14,2,45,0,0]
["sodium citrate","sodium citrate","C102006",88,5,4,0,12,0,0]
["sodium hexafluorostanate","sodium hexafluorostanate","C035907",2,0,0,0,0,0,0]
["sodium phosphate","sodium phosphate","C018279",110,5,0,0,3,0,0]
["sodium pyrophosphate","sodium pyrophosphate","C003319",20,0,0,0,0,0,0]
["sokotrasterol sulfate","sokotrasterol sulfate","C041016",0,0,0,1,0,0,0]
["Solid Waste","Solid Waste","D062611",141,0,0,0,0,0,0]
["Soman","Soman","D012999",46,9,8,2,4,1,0]
["sophoranone","sophoranone","C461819",0,0,0,0,2,0,0]
["Sorbic Acid","Sorbic Acid","D013011",184,8,2,0,0,3,0]
["soyasapogenol A","soyasapogenol A","C116604",4,0,0,0,4,0,0]
["Sparteine","Sparteine","D013034",10,0,0,0,0,0,0]
["Spermine","Spermine","D013096",187,10,80,2,168,8,0]
["SPI031","SPI031","C000622119",0,0,2,0,0,0,0]
["SPIKET-P","SPIKET-P","C409002",0,0,0,0,1,0,0]
["spiradoline","spiradoline","C051272",0,1,0,0,0,0,0]
["spiroglumide","spiroglumide","C076954",2,0,0,0,0,0,0]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C23428,B23428)","v":"spiropyran"},"spiropyran","C088184",24,0,0,0,0,0,0]
["sporidesmin","sporidesmin","C001873",0,1,0,0,0,0,0]
["SR 13193","SR 13193","C500402",0,0,2,0,0,0,0]
["SR 33805","SR 33805","C084255",0,0,0,1,0,0,0]
["SRT3025","SRT3025","C000601293",0,0,2,0,0,0,0]
["ST 91","ST 91","C011266",2,0,0,0,0,0,0]
["stage-specific embryonic antigen-3","stage-specific embryonic antigen-3","C052924",0,0,3,0,1,0,0]
["stambomycin C","stambomycin C","C558883",0,0,2,0,0,0,0]
["staphylotoxin","staphylotoxin","C036117",4,0,0,0,1,0,0]
["staurosporine aglycone","staurosporine aglycone","C049985",3,0,6,0,20,0,0]
["steffimycin","steffimycin","C009944",0,0,2,0,0,0,0]
["stevioside","stevioside","C012043",24,0,7,0,9,0,0]
["stilbazolium merocyanine","stilbazolium merocyanine","C095319",2,0,0,0,0,0,0]
["stiripentol","stiripentol","C021092",2,0,0,0,0,0,0]
["streptothricin F","streptothricin F","C009156",0,0,0,0,0,1,0]
["STRO-1 antigen, rat","STRO-1 antigen, rat","C527498",0,0,2,0,0,0,0]
["strychnine N-oxide","strychnine N-oxide","C083068",0,0,0,0,2,0,0]
["styryldivinyl benzene","styryldivinyl benzene","C118675",2,0,0,0,0,0,0]
["suberic bishydroxamate","suberic bishydroxamate","C493163",0,0,0,0,8,0,0]
["suberin","suberin","C065875",8,0,0,0,0,0,0]
["sucrose monolaurate","sucrose monolaurate","C018152",12,2,0,0,0,0,0]
["sudan III","sudan III","C033006",6,0,2,0,2,0,0]
["sulcotrione","sulcotrione","C079906",12,0,0,0,0,0,0]
["sulfametrole","sulfametrole","C012047",2,0,0,0,0,0,0]
["sulfamidochrysoidine","sulfamidochrysoidine","C003359",2,0,0,0,0,0,0]
["sulfinyl nitrite","sulfinyl nitrite","C569942",0,0,0,0,2,0,0]
["sulfoquinovosyl diglyceride","sulfoquinovosyl diglyceride","C013694",4,0,7,0,6,1,0]
["sulfoquinovosylacylglycerol","sulfoquinovosylacylglycerol","C496611",0,1,0,0,0,0,0]
["Suloctidil","Suloctidil","D013468",2,0,0,2,0,0,0]
["sultopride","sultopride","C012052",6,2,0,0,0,0,0]
["superphosphate","superphosphate","C033414",2,0,0,0,0,0,0]
["Suprofen","Suprofen","D013496",12,0,0,0,0,0,0]
["SY0916","SY0916","C550310",0,0,2,0,2,0,0]
["syringopicroside","syringopicroside","C038066",2,0,0,0,0,0,0]
["T 0070907","T 0070907","C458508",0,0,6,0,6,0,0]
["T 588","T 588","C082372",0,0,0,0,2,0,0]
["taccalonolide AF","taccalonolide AF","C570720",0,0,4,0,0,0,0]
["Tadalafil","Tadalafil","D000068581",12,4,15,2,25,0,0]
["taiwanin A","taiwanin A","C419332",0,0,2,0,9,0,0]
["talatisamine","talatisamine","C069834",0,0,0,0,2,0,0]
["talniflumate","talniflumate","C488233",4,0,0,0,0,0,0]
["TAN 1323 C","TAN 1323 C","C092165",0,0,0,1,0,0,0]
["taraxerol acetate","taraxerol acetate","C404196",0,0,3,0,4,0,0]
["tashinone IIA","tashinone IIA","C530742",0,0,2,0,0,0,0]
["Taurochenodeoxycholic Acid","Taurochenodeoxycholic Acid","D013655",10,3,23,1,137,0,0]
["Taurolithocholic Acid","Taurolithocholic Acid","D013658",8,4,0,0,20,0,0]
["taxodione","taxodione","C009387",0,0,0,0,4,0,0]
["TBE 31","TBE 31","C531972",0,0,4,0,4,0,0]
["tebufenozide","tebufenozide","C082026",0,0,2,0,4,0,0]
["technetium Tc 99m bis(1,2-dimethylphosphino)ethane","technetium Tc 99m bis(1,2-dimethylphosphino)ethane","C031898",2,0,0,0,0,0,0]
["technetium Tc 99m propylene amine oxime","technetium Tc 99m propylene amine oxime","C044310",2,0,0,0,0,0,0]
["Technetium Tc 99m Pyrophosphate","Technetium Tc 99m Pyrophosphate","D016698",6,16,0,0,0,0,0]
["teferrol","teferrol","C013276",8,0,0,0,0,0,0]
["teleocidins","teleocidins","C022176",0,1,0,0,4,0,0]
["Temazepam","Temazepam","D013693",12,1,0,0,0,0,0]
["tempidon","tempidon","C002273",2,0,0,0,0,0,0]
["tenovin-1","tenovin-1","C000594735",0,0,2,0,2,0,0]
["tenuigenin","tenuigenin","C493220",0,0,2,0,8,0,0]
["terminaloside M","terminaloside M","C000613793",0,0,2,0,0,0,0]
["tert.-butylcarbamoylquinine","tert.-butylcarbamoylquinine","C419303",2,0,0,0,0,0,0]
["tert-butylbicyclo-2-benzoate","tert-butylbicyclo-2-benzoate","C046308",4,0,0,0,0,0,0]
["Testolactone","Testolactone","D013738",2,0,0,0,0,0,0]
["tetra(p-dimethylaminophenyl)porphyrin","tetra(p-dimethylaminophenyl)porphyrin","C540002",2,0,0,0,0,0,0]
["tetrabromophenolphthalein ethyl ester","tetrabromophenolphthalein ethyl ester","C018157",2,0,0,0,0,0,0]
["tetrachloroisophthalonitrile","tetrachloroisophthalonitrile","C005806",14,0,0,0,2,0,0]
["tetraethyl anthracene-9,10-diyl-9,10-bis(phosphonate)","tetraethyl anthracene-9,10-diyl-9,10-bis(phosphonate)","C587916",0,0,0,0,2,0,0]
["Tetrahydropapaveroline","Tetrahydropapaveroline","D013765",6,1,0,0,7,0,0]
["tetrakis(2-hydroxyethyl)orthosilicate","tetrakis(2-hydroxyethyl)orthosilicate","C524896",2,0,0,0,0,0,0]
["tetramethylolphosphonium chloride","tetramethylolphosphonium chloride","C014850",4,0,1,0,0,0,0]
["tetrandrine","tetrandrine","C009438",16,3,84,7,162,0,0]
["tetraphenylphosphonium polyoxomolybdate","tetraphenylphosphonium polyoxomolybdate","C519104",0,1,2,0,0,0,0]
["tetrazanbigen","tetrazanbigen","C552897",0,0,2,0,2,0,0]
["tetronic 701","tetronic 701","C012571",0,0,6,0,0,0,0]
["tezampanel","tezampanel","C082309",2,0,0,0,0,0,0]
["thailanstatin C","thailanstatin C","C582012",0,0,2,0,0,0,0]
["theaflavin digallate","theaflavin digallate","C077197",0,0,0,0,9,0,0]
["thermospermine","thermospermine","C021097",3,0,1,0,0,0,0]
["thiazinogeldanamycin","thiazinogeldanamycin","C000613167",2,0,0,0,0,0,0]
["thidiazuron","thidiazuron","C016785",0,0,2,0,0,0,0]
["thieno(3,2-d)(1,2,3)triazolo(1,5-a)pyrimidine","thieno(3,2-d)(1,2,3)triazolo(1,5-a)pyrimidine","C586343",0,0,2,0,0,0,0]
["thiobenzamide","thiobenzamide","C015539",4,5,0,0,0,0,0]
["thiocyanic acid","thiocyanic acid","C026976",6,0,0,0,0,0,0]
["thiometon","thiometon","C100178",2,0,0,0,0,0,0]
["thiopalmitic acid","thiopalmitic acid","C091863",2,0,0,0,0,0,0]
["thiosuccinic acid","thiosuccinic acid","C024599",4,0,0,0,0,0,0]
["thomasidioic acid","thomasidioic acid","C475898",2,0,0,0,0,0,0]
["thulium-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate","thulium-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate","C463281",2,0,0,0,0,0,0]
["thyrsiferyl 23-acetate","thyrsiferyl 23-acetate","C091148",0,0,0,0,3,0,0]
["tian-xian","tian-xian","C568834",0,0,4,0,2,0,0]
["tibolone","tibolone","C027385",0,6,21,3,10,0,0]
["Tiletamine","Tiletamine","D013992",19,0,0,0,0,0,0]
["tiludronic acid","tiludronic acid","C058651",2,0,3,0,5,0,0]
["tinuvin","tinuvin","C016151",0,0,2,0,0,0,0]
["Titanium-Niobium-Hafnium alloy","Titanium-Niobium-Hafnium alloy","C000611998",0,0,2,0,0,0,0]
["TKI-31","TKI-31","C515161",0,0,2,0,0,0,0]
["TMU-35435","TMU-35435","C000622070",0,0,0,0,2,0,0]
["tocopherol monoglucoside","tocopherol monoglucoside","C460320",2,0,0,0,0,0,0]
["Todralazine","Todralazine","D014032",2,1,0,0,0,2,0]
["Tolnaftate","Tolnaftate","D014047",6,0,0,0,0,0,0]
["toosendanin","toosendanin","C036454",0,0,10,0,24,1,0]
["topsentin","topsentin","C070184",0,0,2,0,2,0,0]
["Toxaphene","Toxaphene","D014112",4,0,0,0,3,0,0]
["toxin VII","toxin VII","C042143",2,0,0,0,0,0,0]
["TP202377","TP202377","C581196",0,0,2,0,0,0,0]
["Traceptin","Traceptin","C025011",2,0,0,0,0,0,0]
["trans-2-(4'-(N,N-dimethylamino)styryl)imidazo(4,5-b)pyridine","trans-2-(4'-(N,N-dimethylamino)styryl)imidazo(4,5-b)pyridine","C000598103",2,0,0,0,0,0,0]
["trans-3-(4'-hydroxyphenyl)-2-propenoic acid","trans-3-(4'-hydroxyphenyl)-2-propenoic acid","C495469",0,0,2,0,0,0,0]
["trans-N-vinylformamide","trans-N-vinylformamide","C581348",4,0,0,0,0,0,0]
["trehazolin","trehazolin","C071816",4,0,0,0,0,0,0]
["triacsin C","triacsin C","C034613",0,0,0,0,6,0,0]
["triazolaminoquinoleine","triazolaminoquinoleine","C465922",2,0,0,0,0,0,0]
["tributylphenyltetraethoxylate","tributylphenyltetraethoxylate","C479481",2,0,0,0,0,0,0]
["Trichlorfon","Trichlorfon","D014236",27,5,0,0,5,0,0]
["trichloroacetamide","trichloroacetamide","C009528",2,0,0,0,0,0,0]
["trichothecene NX-2","trichothecene NX-2","C000608633",2,0,0,0,0,0,0]
["triethyl phosphate","triethyl phosphate","C009549",2,0,0,0,0,0,0]
["triethylamine","triethylamine","C016162",23,0,0,0,0,0,0]
["trifluoroacetic anhydride","trifluoroacetic anhydride","C017958",0,0,2,0,2,0,0]
["trigonoliimine A","trigonoliimine A","C551376",0,0,2,0,0,0,0]
["trijuganone C","trijuganone C","C071585",0,0,0,0,1,0,0]
["trimellitic anhydride","trimellitic anhydride","C015559",0,2,5,0,0,0,0]
["trimethaphan camsylate","trimethaphan camsylate","C017774",2,0,0,0,0,0,0]
["trimethyltin","trimethyltin","C046488",4,7,6,0,35,0,0]
["Trimipramine","Trimipramine","D014299",6,0,0,0,0,0,0]
["triolimus","triolimus","C578609",0,1,4,0,0,0,0]
["triphenyltetrazolium","triphenyltetrazolium","C009591",12,10,0,0,1,0,0]
["tripterine","tripterine","C050414",6,4,117,8,170,0,0]
["tris(2,2'-bipyridine)osmium(II)","tris(2,2'-bipyridine)osmium(II)","C069311",2,0,0,0,0,0,0]
["tris(2-maleimidoethyl)amine","tris(2-maleimidoethyl)amine","C434955",0,0,0,0,0,1,0]
["tris(9,10-phenanthrenequinone diimine)ruthenium(II)","tris(9,10-phenanthrenequinone diimine)ruthenium(II)","C541998",0,0,2,0,0,0,0]
["tris-2,2,2-(3-(4,4'-dimethoxytrityloxy)propyloxymethyl)ethyl-N,N-diisopropylaminocyanethoxy phosphoramidite","tris-2,2,2-(3-(4,4'-dimethoxytrityloxy)propyloxymethyl)ethyl-N,N-diisopropylaminocyanethoxy phosphoramidite","C497025",0,0,2,0,0,0,0]
["trityloxymethyl butyrolactol","trityloxymethyl butyrolactol","C496795",2,0,0,0,0,0,0]
["Troeger's base","Troeger's base","C083830",2,0,2,0,0,0,0]
["tryptamine","tryptamine","C030820",8,0,4,0,4,1,0]
["TSWU-CD4 compound","TSWU-CD4 compound","C000600957",0,0,0,0,2,0,0]
["tubliseal","tubliseal","C048769",0,1,0,0,0,0,0]
["tulobuterol","tulobuterol","C010809",6,2,0,0,0,0,0]
["turimycin","turimycin","C011138",2,0,0,0,0,0,0]
["TX3 toxin, Buthus martensii","TX3 toxin, Buthus martensii","C418406",0,0,0,0,0,1,0]
["Ty21a typhoid vaccine","Ty21a typhoid vaccine","C072772",2,0,0,0,0,0,0]
["Tyrode's solution","Tyrode's solution","C037692",6,0,0,0,0,0,0]
["U 54494A","U 54494A","C054216",2,1,0,0,0,0,0]
["UAMC-2526","UAMC-2526","C000621420",0,0,2,0,0,0,0]
["ubiquinone-O","ubiquinone-O","C109863",4,0,0,0,6,0,0]
["UDP-glucosamine","UDP-glucosamine","C026712",2,0,0,0,0,0,0]
["UltraCal XS","UltraCal XS","C531021",2,0,0,0,0,0,0]
["UMF 078","UMF 078","C089375",2,0,0,0,0,0,0]
["UNC1999","UNC1999","C000619732",0,0,2,0,2,0,0]
["Unifil S","Unifil S","C483424",2,0,0,0,0,0,0]
["uremia middle molecule toxins","uremia middle molecule toxins","C026865",0,0,0,0,2,0,0]
["urovision","urovision","C027278",4,0,0,0,0,0,0]
["usabamycin C","usabamycin C","C571321",0,0,2,0,0,0,0]
["V 10367","V 10367","C108850",0,0,0,0,4,0,0]
["valencene","valencene","C506706",0,0,2,0,0,0,0]
["valproic acid glucuronide","valproic acid glucuronide","C041285",2,0,0,0,0,0,0]
["vanadicene dithiocarbamate","vanadicene dithiocarbamate","C421742",0,0,0,0,2,0,0]
["vanillyl nonanoate","vanillyl nonanoate","C508530",0,0,0,0,2,0,0]
["VEL-0230","VEL-0230","C000599727",0,0,0,0,2,0,0]
["veratraldehyde","veratraldehyde","C427725",2,0,0,0,0,0,0]
["vernolide-A","vernolide-A","C558651",0,0,6,2,2,0,0]
["versicolorin C","versicolorin C","C029827",0,0,2,0,0,0,0]
["vexibinol","vexibinol","C064849",2,0,0,0,4,0,0]
["vicenin","vicenin","C117329",0,0,0,0,2,0,0]
["Vindesine","Vindesine","D014751",0,0,0,0,2,0,0]
["vinylidene chloride","vinylidene chloride","C029297",2,1,0,0,2,1,0]
["viridicatumtoxin","viridicatumtoxin","C042170",0,1,0,0,0,0,0]
["Vitamin B 6","Vitamin B 6","D025101",36,0,13,3,19,1,0]
["vitamin MK 7","vitamin MK 7","C062629",6,0,1,0,0,1,0]
["vitexin rhamnoside","vitexin rhamnoside","C021329",2,0,0,0,2,0,0]
["vitexin-2-O-xyloside","vitexin-2-O-xyloside","C586695",0,0,4,0,3,0,0]
["vitisin A","vitisin A","C412469",2,0,2,0,4,0,0]
["Vitrabond","Vitrabond","C067790",18,1,0,0,0,0,0]
["Vitremer","Vitremer","C084550",48,0,0,0,0,0,0]
["Vivaglass Fil","Vivaglass Fil","C119198",2,0,0,0,0,0,0]
["VLE 776","VLE 776","C434322",0,0,0,0,0,1,0]
["VLX1570","VLX1570","C000623193",0,0,2,0,4,0,0]
["VLX40","VLX40","C584431",0,0,0,0,2,0,0]
["VLX600","VLX600","C000602558",0,0,2,0,0,0,0]
["VN-66-1 compound","VN-66-1 compound","C529070",0,0,2,0,2,0,0]
["VNP 20009","VNP 20009","C465023",0,0,3,0,1,0,0]
["VNPT55","VNPT55","C000609869",0,0,0,0,1,0,0]
["VO(Br,OH-acph)2","VO(Br,OH-acph)2","C118178",0,0,0,0,1,0,0]
["voacamine","voacamine","C005891",0,0,0,0,7,0,0]
["voacangine","voacangine","C012098",0,0,1,1,0,0,0]
["vobasine","vobasine","C057239",0,0,0,0,1,0,0]
["voglibose","voglibose","C102817",0,1,1,0,0,0,0]
["volinanserin","volinanserin","C079049",2,0,0,0,0,0,0]
["volonomycin","volonomycin","C012680",2,0,0,0,0,0,0]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C25412,B25412)","v":"vomilenine"},"vomilenine","C119909",2,0,0,0,0,0,0]
["VO-OHpic","VO-OHpic","C000600334",0,0,2,0,0,0,0]
["vorapaxar","vorapaxar","C530299",0,0,0,0,1,0,0]
["Voriconazole","Voriconazole","D065819",25,5,14,0,2,0,0]
["vorinostat","vorinostat","C111237",2,3,319,11,503,0,0]
["vorozole","vorozole","C060523",0,0,0,0,2,0,0]
["vortioxetine","vortioxetine","C557874",0,0,2,0,0,0,0]
["vosaroxin","vosaroxin","C485113",0,1,4,0,15,0,0]
["vouacapan","vouacapan","C073437",0,0,2,0,0,0,0]
["VPS Coriolus versicolor extract","VPS Coriolus versicolor extract","C504606",0,0,2,0,2,0,0]
["VRT 532","VRT 532","C535089",0,2,0,0,0,0,0]
["VRX0466617","VRX0466617","C520468",0,0,2,0,2,0,0]
["VS-5584","VS-5584","C585120",0,0,4,0,0,0,0]
["VST-50","VST-50","C587763",0,1,0,0,0,0,0]
["VT-464","VT-464","C000601472",0,0,2,0,0,0,0]
["VUFB 13468","VUFB 13468","C034234",0,0,0,0,2,0,0]
["VX","VX","C009680",16,4,0,0,2,0,0]
["VX680","VX680","C484810",0,0,31,0,52,0,0]
["VX-944","VX-944","C504340",0,0,2,0,2,0,0]
["VX-970","VX-970","C000598331",0,0,2,0,2,0,0]
["VX-VC 43","VX-VC 43","C045065",2,0,0,0,0,0,0]
["VyproII","VyproII","C510058",0,1,0,0,0,0,0]
["W 6211","W 6211","C049612",2,0,0,0,0,0,0]
["W 7","W 7","C017967",5,0,0,0,2,0,0]
["waixenicin A","waixenicin A","C568854",0,0,2,0,0,0,0]
["wakayin","wakayin","C508208",0,0,4,0,0,0,0]
["walsuronoid B","walsuronoid B","C521919",0,0,2,0,2,0,0]
["waltherione-A","waltherione-A","C502881",0,0,2,0,4,0,0]
["waltherione-B","waltherione-B","C540622",0,0,2,0,4,0,0]
["warifteine","warifteine","C003931",0,0,4,0,0,0,0]
["warkmycin","warkmycin","C586019",0,0,2,0,0,0,0]
["Waste Water","Waste Water","D062065",1178,3,28,0,13,4,0]
["water soluble chitin","water soluble chitin","C400945",4,0,2,0,2,0,0]
["wave flowable composite","wave flowable composite","C471181",0,0,2,0,0,0,0]
["WAY 120491","WAY 120491","C067406",2,0,0,0,0,0,0]
["WAY 200070","WAY 200070","C502077",0,0,1,0,0,0,0]
["WAY-362450","WAY-362450","C540004",0,0,0,0,2,0,0]
["WB-38 compound","WB-38 compound","C000604215",0,0,2,0,2,0,0]
["WC3 rotavirus vaccine","WC3 rotavirus vaccine","C058442",2,0,0,0,0,0,0]
["WC-II-89","WC-II-89","C540207",0,0,0,0,2,0,0]
["We 201","We 201","C006065",6,0,2,0,0,0,0]
["weddellite","weddellite","C016188",4,0,0,0,0,0,0]
["wedelolactone","wedelolactone","C051122",2,0,12,1,15,0,0]
["weicao","weicao","C531139",2,0,0,0,0,0,0]
["Weichang'an","Weichang'an","C528002",0,0,0,0,2,0,0]
["Wei-Chang-An-Wan","Wei-Chang-An-Wan","C545640",0,0,2,0,0,0,0]
["weiganli","weiganli","C540476",0,0,2,0,0,0,0]
["weikangfu","weikangfu","C510020",0,0,0,0,2,0,0]
["weikangning","weikangning","C550198",0,0,2,0,0,0,0]
["weiqi","weiqi","C000595070",0,0,2,0,2,0,0]
["weisiensin B","weisiensin B","C539120",0,1,0,0,4,0,0]
["welan","welan","C068570",6,0,0,0,0,0,0]
["welsonin A1","welsonin A1","C000611401",0,0,2,0,0,0,0]
["welsonin A2","welsonin A2","C000611402",0,0,2,0,0,0,0]
["wen luo yin","wen luo yin","C587446",0,0,0,1,0,0,0]
["wenhua juanbi","wenhua juanbi","C588019",0,0,2,0,2,0,0]
["wenpi decoction","wenpi decoction","C523153",0,0,2,0,2,0,0]
["wen-pi-tang","wen-pi-tang","C474692",0,0,0,0,4,0,0]
["wenshen xiaozheng tang","wenshen xiaozheng tang","C000592912",0,0,4,1,2,0,0]
["wentilactone B","wentilactone B","C454809",0,0,2,0,4,0,0]
["wenxia changfu","wenxia changfu","C571442",0,0,2,0,2,0,0]
["wenyang huazho tongluo","wenyang huazho tongluo","C000610657",0,0,2,0,2,0,0]
["wenyangbushen","wenyangbushen","C000610758",0,0,0,0,2,0,0]
["WF 16775 A1","WF 16775 A1","C079474",0,0,0,1,0,0,0]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C25476,B25476)","v":"WF 16775 A2"},"WF 16775 A2","C079475",0,0,0,1,0,0,0]
["WF-208","WF-208","C000604983",0,0,2,0,2,0,0]
["whewellite","whewellite","C016189",8,0,0,0,0,0,0]
["WHI P131","WHI P131","C116180",0,0,0,0,7,0,0]
["WHI P154","WHI P154","C113888",0,0,0,0,3,0,0]
["WIB801C","WIB801C","C000605556",0,0,1,0,0,0,0]
["widdrol","widdrol","C078670",0,0,2,1,4,0,0]
["Wikyungtang","Wikyungtang","C493316",0,0,0,0,2,0,0]
["wilforonide","wilforonide","C431468",2,0,0,0,0,0,0]
["wilfortrine","wilfortrine","C062677",0,0,4,0,2,0,0]
["wilfoside C3N","wilfoside C3N","C535061",0,0,2,0,1,0,0]
["William's medium E","William's medium E","C475563",0,0,1,0,1,0,0]
["WIN 22169","WIN 22169","C091449",2,0,0,0,0,0,0]
["WIN 34B","WIN 34B","C569023",0,0,2,0,0,0,0]
["Win 54954","Win 54954","C062554",0,1,0,0,2,0,0]
["Win 55212-2","Win 55212-2","C070417",0,3,31,2,53,0,0]
["Win 57273","Win 57273","C062556",6,0,0,0,0,0,0]
["WIN 62577","WIN 62577","C086110",0,0,3,0,0,0,0]
["WIN 64338","WIN 64338","C087374",0,2,0,0,0,0,0]
["withacnistin","withacnistin","C441970",0,0,0,0,2,0,0]
["withaferin A","withaferin A","C009684",0,2,74,3,141,0,0]
["withangulatin A","withangulatin A","C059043",0,0,0,0,2,0,0]
["withanolide D","withanolide D","C010376",0,0,0,0,5,0,0]
["withaphysalin F","withaphysalin F","C488716",0,0,2,0,0,0,0]
["withaphysalin M","withaphysalin M","C486267",0,0,2,0,1,0,0]
["withaphysalin N","withaphysalin N","C486265",0,0,2,0,1,0,0]
["withaphysalin O","withaphysalin O","C486266",0,0,2,0,1,0,0]
["WJ1376-1","WJ1376-1","C000588914",0,0,0,0,2,0,0]
["WJ1398-1","WJ1398-1","C000588915",0,0,0,0,2,0,0]
["WK175","WK175","C450199",0,0,0,0,2,0,0]
["WK234 compound","WK234 compound","C561686",0,0,2,0,2,0,0]
["WL 276","WL 276","C530697",0,0,0,0,1,0,0]
["WM130 compound","WM130 compound","C000602836",0,0,6,0,4,0,0]
["WMC-79","WMC-79","C506941",0,0,0,0,2,0,0]
["WMJ-S-001","WMJ-S-001","C000600248",0,0,3,1,3,0,0]
["wodeshiol","wodeshiol","C410704",2,0,0,0,0,0,0]
["wogonin","wogonin","C085514",6,0,59,6,138,0,0]
["wogonoside","wogonoside","C473995",6,0,8,1,6,0,0]
["wood vinegar","wood vinegar","C080339",0,0,0,0,2,0,0]
["woodfordin C","woodfordin C","C065469",0,0,0,0,2,0,0]
["wortmannin","wortmannin","C009687",6,3,16,2,57,0,0]
["WP 1193","WP 1193","C551527",0,0,0,0,2,0,0]
["WP 631","WP 631","C104426",0,0,2,0,18,0,0]
["WP 744","WP 744","C451735",0,0,0,0,5,0,0]
["WP 936","WP 936","C518183",0,0,0,0,2,0,0]
["WP-1034","WP-1034","C505031",0,0,0,0,2,0,0]
["WP760","WP760","C523719",0,0,0,0,2,0,0]
["WR 1065","WR 1065","C020174",14,1,1,0,10,12,0]
["WR 151327","WR 151327","C048392",0,1,0,0,0,1,0]
["WR 77913","WR 77913","C035284",0,1,0,0,0,0,0]
["WS 79089A","WS 79089A","C088493",2,0,0,0,0,0,0]
["WS 79089B","WS 79089B","C088494",2,0,0,0,0,0,0]
["WS 79089C","WS 79089C","C088495",2,0,0,0,0,0,0]
["WS6 compound","WS6 compound","C000604999",0,0,2,0,0,0,0]
["WSS25 glucan","WSS25 glucan","C553930",0,0,0,1,0,0,0]
["wubeizi","wubeizi","C000601190",0,0,2,0,0,0,0]
["wuyaoshunqisan","wuyaoshunqisan","C473660",0,0,0,0,2,0,0]
["wuzhi","wuzhi","C582515",0,0,2,0,0,0,0]
["wuzi yanzong","wuzi yanzong","C528421",0,1,0,0,6,0,0]
["WW-781","WW-781","C031916",2,0,0,0,0,0,0]
["WW85 compound","WW85 compound","C506898",0,0,0,0,4,0,0]
["Wy 26703","Wy 26703","C038538",2,0,0,0,0,0,0]
["Wy 41770","Wy 41770","C042276",2,0,0,0,0,0,0]
["WY 45727","WY 45727","C053415",2,0,0,0,0,0,0]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C25540,B25540)","v":"WYC02-9"},"WYC02-9","C585836",0,0,0,1,4,0,0]
["wye","wye","C012099",0,0,2,0,2,0,0]
["WYE 125132","WYE 125132","C547581",0,0,1,0,3,0,0]
["WYE-354","WYE-354","C000614249",0,0,0,0,4,0,0]
["WYE-687","WYE-687","C000608239",0,0,4,0,4,0,0]
["WYK431","WYK431","C000594718",0,0,2,0,2,0,0]
["WZ4002","WZ4002","C571455",0,0,2,0,0,0,0]
["WZ4003","WZ4003","C586755",0,0,2,0,0,0,0]
["WZ4-49-1","WZ4-49-1","C000623223",0,0,0,0,2,0,0]
["WZB117","WZB117","C576807",0,0,4,0,0,0,0]
["X22 compound","X22 compound","C000600451",0,0,0,0,4,0,0]
["X-370 compound","X-370 compound","C000600791",0,0,2,0,2,0,0]
["X-387","X-387","C572198",0,0,2,0,0,0,0]
["XAD-4 resin","XAD-4 resin","C012101",24,0,0,0,0,0,0]
["xaliproden","xaliproden","C462299",0,0,2,0,0,0,0]
["Xamoterol","Xamoterol","D017307",2,0,0,0,0,0,0]
["xanafide","xanafide","C522694",0,0,1,0,0,0,0]
["xanomeline","xanomeline","C075257",4,0,0,0,0,0,0]
["xanthan gum","xanthan gum","C002563",120,4,14,0,2,3,0]
["xanthatin","xanthatin","C022186",0,0,17,2,8,0,0]
["xanthenone-4-acetic acid","xanthenone-4-acetic acid","C066138",0,3,2,0,0,0,0]
["Xanthine","Xanthine","D019820",32,0,4,0,3,1,0]
["Xanthinol Niacinate","Xanthinol Niacinate","D014971",0,1,2,0,0,0,0]
["xanthoangelol","xanthoangelol","C068244",0,0,2,0,6,0,0]
["xanthobilirubic acid","xanthobilirubic acid","C013337",4,0,0,0,0,0,0]
["xanthoceraside","xanthoceraside","C548611",0,0,0,0,4,0,0]
["xanthochymol","xanthochymol","C414432",0,0,0,0,4,0,0]
["xanthohumol","xanthohumol","C104536",4,0,70,8,82,2,0]
["xantholipin","xantholipin","C573547",0,0,0,0,2,0,0]
["xanthomegnin","xanthomegnin","C009688",2,0,0,0,0,1,0]
["xanthomicrol","xanthomicrol","C462036",0,0,4,0,0,0,0]
["xanthommatin","xanthommatin","C002866",4,0,0,0,0,0,0]
["xanthomonadin I","xanthomonadin I","C108932",0,0,0,0,0,1,0]
["xanthone","xanthone","C009689",4,0,25,1,21,0,0]
["Xanthopterin","Xanthopterin","D014976",4,0,2,0,0,0,0]
["xanthorrhizol","xanthorrhizol","C120248",2,0,2,0,12,0,0]
["xanthoxyletin","xanthoxyletin","C477468",0,0,4,0,4,0,0]
["xanthurenic acid","xanthurenic acid","C028330",8,0,0,0,4,0,0]
["xantocillin","xantocillin","C493153",0,0,2,0,2,0,0]
["XAV939","XAV939","C544261",0,0,13,0,9,0,0]
["XCT790","XCT790","C488234",0,1,10,1,2,0,0]
["XE 820","XE 820","C078981",2,0,0,0,0,0,0]
["xeniolide F","xeniolide F","C461725",0,0,2,0,0,0,0]
["Xeno compomer","Xeno compomer","C417842",6,0,1,0,0,0,0]
["Xeno III","Xeno III","C487957",10,0,0,0,3,0,0]
["Xeno V","Xeno V","C575872",0,0,0,0,1,0,0]
["xerophilusin B","xerophilusin B","C410911",0,0,2,0,2,0,0]
["xestoquinone","xestoquinone","C068501",0,0,0,0,2,0,0]
["XI-006","XI-006","C000607970",0,0,0,0,4,0,0]
["xiamycin","xiamycin","C556785",0,0,2,0,0,0,0]
["Xianhe Yanling","Xianhe Yanling","C561425",0,0,2,0,0,0,0]
["xiao zhi ling","xiao zhi ling","C120431",0,1,0,0,0,0,0]
["xiaobuxin-tang","xiaobuxin-tang","C532342",0,0,2,0,0,0,0]
["xiaoji","xiaoji","C000597954",0,0,4,0,4,0,0]
["xiaotan sanjie","xiaotan sanjie","C000598250",0,0,2,2,0,0,0]
["xiaotan tongfu","xiaotan tongfu","C000589577",2,0,2,0,2,0,0]
["xiao-xu-ming","xiao-xu-ming","C548754",0,0,0,0,4,0,0]
["xiaoyao","xiaoyao","C516449",0,0,2,0,0,0,0]
["XIE18-6 compound","XIE18-6 compound","C000611987",0,0,2,0,0,0,0]
["Xiexin decoction","Xiexin decoction","C518364",0,0,2,0,1,0,0]
["xihuang","xihuang","C000598753",0,0,2,0,0,0,0]
["xilobam","xilobam","C017798",2,0,0,0,0,0,0]
["ximelagatran","ximelagatran","C426686",0,1,0,0,2,0,0]
["ximenynic acid","ximenynic acid","C053760",0,0,2,1,2,0,0]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C25604,B25604)","v":"ximoprofen"},"ximoprofen","C061944",2,0,0,0,0,0,0]
["xingbi","xingbi","C000613610",0,2,0,0,0,0,0]
["Xingren","Xingren","C000612342",0,0,2,0,0,0,0]
["xinjiachalcone A","xinjiachalcone A","C000608131",0,0,2,0,0,0,0]
["Xinnao Shutong","Xinnao Shutong","C528303",0,0,0,0,2,0,0]
["xinqin","xinqin","C000617119",0,2,0,0,0,0,0]
["xiongshao","xiongshao","C528128",0,0,4,0,2,0,0]
["Xipamide","Xipamide","D014988",8,0,0,0,0,0,0]
["XJB-5-131","XJB-5-131","C523959",0,0,0,0,1,0,0]
["XK 469","XK 469","C118180",2,0,8,0,11,0,0]
["XL 888","XL 888","C559121",0,0,6,0,2,0,0]
["XL147","XL147","C581157",0,0,4,1,1,0,0]
["XL413 compound","XL413 compound","C574818",0,0,6,0,2,0,0]
["XL647","XL647","C571826",0,0,2,0,2,0,0]
["XL765","XL765","C576808",0,0,7,1,5,0,0]
["XLR-11","XLR-11","C585106",0,0,0,0,2,0,0]
["XM 462","XM 462","C530382",0,0,2,0,4,0,0]
["XMD 8-92","XMD 8-92","C568790",0,0,4,1,0,0,0]
["XMD15-44","XMD15-44","C000605794",0,0,2,0,0,0,0]
["XP-Bond","XP-Bond","C532387",0,0,4,0,2,0,0]
["XR5944","XR5944","C434883",0,0,0,0,2,0,0]
["XRP44X compound","XRP44X compound","C527882",0,0,2,0,0,0,0]
["XRP6258","XRP6258","C532412",0,0,0,0,2,0,0]
["Xuebijing","Xuebijing","C549376",0,1,3,0,7,0,0]
["Xue-Fu-Zhu-Yu decoction","Xue-Fu-Zhu-Yu decoction","C513826",0,0,6,1,2,0,0]
["XUESETONG","XUESETONG","C509799",0,0,0,1,4,0,0]
["xueyu danhuang","xueyu danhuang","C000612393",0,0,2,0,0,0,0]
["xuezhikang","xuezhikang","C496822",0,0,2,0,6,0,0]
["XY99-5038","XY99-5038","C431083",0,0,0,0,3,0,0]
["xylene cyanol","xylene cyanol","C048951",2,0,0,0,0,0,0]
["xylenol orange","xylenol orange","C016833",22,0,0,0,0,0,0]
["Xylitol","Xylitol","D014993",212,5,13,1,7,2,0]
["xylobiose","xylobiose","C004173",6,0,0,0,0,0,0]
["xylogalacturonan","xylogalacturonan","C465879",2,0,0,0,0,0,0]
["xyloglucan","xyloglucan","C029353",44,3,13,0,6,3,0]
["xyloketal B","xyloketal B","C515343",0,0,2,0,2,0,0]
["xylooligosaccharide","xylooligosaccharide","C570991",40,0,2,0,0,0,0]
["xylopine","xylopine","C062700",0,0,0,0,2,0,0]
["xylopyranose","xylopyranose","C431715",0,0,0,0,2,0,0]
["xylose 1-phosphate","xylose 1-phosphate","C054739",2,0,0,0,0,0,0]
["xylosides","xylosides","C010807",12,1,9,1,3,0,0]
["xylosyl-1-4-xylosyl-1-(4-methylumbelliferone)","xylosyl-1-4-xylosyl-1-(4-methylumbelliferone)","C091993",2,0,0,0,0,0,0]
["xylosylfructoside","xylosylfructoside","C043602",2,0,0,0,0,0,0]
["xylotriose","xylotriose","C515044",4,0,0,0,0,0,0]
["Xylulose","Xylulose","D014996",10,0,1,0,0,1,0]
["xylulose-5-phosphate","xylulose-5-phosphate","C031625",2,0,0,0,0,0,0]
["xymedon","xymedon","C069705",0,0,0,0,4,0,0]
["Xyz 033 mp","Xyz 033 mp","C417723",0,0,0,0,2,0,0]
["Y 32885","Y 32885","C460080",0,0,0,1,0,0,0]
["Y-0452","Y-0452","C000624118",0,0,0,0,2,0,0]
["Y306zh compound","Y306zh compound","C000598606",0,0,2,0,0,0,0]
["Y-39983","Y-39983","C520365",0,0,2,0,0,0,0]
["Y-632 compound","Y-632 compound","C000613759",0,0,0,0,2,0,0]
["yakuchinone B","yakuchinone B","C121978",0,0,0,0,2,0,0]
["yakuchinone-A","yakuchinone-A","C042566",0,0,0,0,2,0,0]
["yang wei kang liu","yang wei kang liu","C531973",0,0,0,0,2,0,0]
["Yang-Gan-Wan","Yang-Gan-Wan","C415597",0,0,0,0,2,0,0]
["yanghe","yanghe","C533613",0,0,2,0,0,0,0]
["yangjing","yangjing","C000617882",0,0,2,0,0,0,0]
["yangonin","yangonin","C110481",0,0,0,0,2,0,0]
["yangzheng xiaoji","yangzheng xiaoji","C579032",0,0,8,1,4,0,0]
["yaotongning","yaotongning","C000600253",0,0,2,0,0,0,0]
["Yariv reagent","Yariv reagent","C104977",0,0,0,0,2,0,0]
["yatakemycin","yatakemycin","C474180",2,0,0,0,0,0,0]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C25668,B25668)","v":"yatein"},"yatein","C452802",0,0,2,0,0,0,0]
["YC137","YC137","C493272",0,0,2,0,5,0,0]
["YCZ-18","YCZ-18","C000604930",0,0,2,0,0,0,0]
["yellow 2G","yellow 2G","C010377",2,0,0,0,0,0,0]
["yellow 6","yellow 6","C000602706",0,0,1,0,0,0,0]
["Yellow II","Yellow II","C031741",0,1,0,0,0,0,0]
["yellow RL","yellow RL","C551303",2,0,0,0,0,0,0]
["yersiniabactin","yersiniabactin","C104398",0,0,0,0,0,2,0]
["yessotoxin","yessotoxin","C066632",2,2,5,0,33,0,0]
["YF 476","YF 476","C104428",8,1,0,0,0,0,0]
["YF-452","YF-452","C000620091",0,0,0,1,0,0,0]
["YF479 compound","YF479 compound","C000599719",0,0,2,0,0,0,0]
["YH 1885","YH 1885","C108798",3,0,0,0,4,0,0]
["YH 439","YH 439","C098009",2,1,0,0,0,0,0]
["YH-GKA","YH-GKA","C581883",0,0,2,0,2,0,0]
["YHK herbal compound","YHK herbal compound","C516652",0,0,2,0,1,0,0]
["YHO-13351","YHO-13351","C562147",0,0,2,0,2,0,0]
["Yi Guan Jian Decoction","Yi Guan Jian Decoction","C539461",0,0,0,0,2,0,0]
["yifei huoxue","yifei huoxue","C578966",0,0,2,0,0,0,0]
["yifei xuanfei jiangzhuo","yifei xuanfei jiangzhuo","C000607643",0,0,0,0,1,0,0]
["Yi-Gan San","Yi-Gan San","C524644",0,0,2,0,6,0,0]
["yiguanjian decoction","yiguanjian decoction","C576320",0,0,2,1,0,0,0]
["yiki-huoxue","yiki-huoxue","C033946",0,0,0,0,2,0,0]
["yiliuyin","yiliuyin","C540810",0,0,0,1,0,0,0]
["yinchenhao","yinchenhao","C579121",0,0,2,0,4,0,0]
["yinian jiangya","yinian jiangya","C553679",0,0,2,0,0,0,0]
["yiqi huatan","yiqi huatan","C583788",0,0,0,0,2,0,0]
["yi-qi-bu-shen","yi-qi-bu-shen","C568835",0,0,0,0,2,0,0]
["yi-qi-fu-mai","yi-qi-fu-mai","C584693",0,0,0,0,4,0,0]
["yishen","yishen","C525740",0,0,0,0,2,0,0]
["YJA 20379-1","YJA 20379-1","C110270",4,0,0,0,0,0,0]
["YK 4-279","YK 4-279","C562345",0,0,9,0,10,0,0]
["YK-3-237","YK-3-237","C000588455",0,0,2,0,1,0,0]
["YK-5-252","YK-5-252","C000622718",0,0,2,0,0,0,0]
["YLT192","YLT192","C000602658",0,0,2,0,0,0,0]
["YLT256","YLT256","C000613727",0,0,2,0,4,0,0]
["YM 022","YM 022","C087260",2,0,0,0,0,0,0]
["YM 155","YM 155","C523798",0,0,64,1,103,0,0]
["YM 39558","YM 39558","C113467",2,0,0,0,0,0,0]
["YM 529","YM 529","C087958",6,0,11,1,26,0,0]
["YM 60828","YM 60828","C111032",2,0,0,0,0,0,0]
["YM 872","YM 872","C110629",0,3,2,0,0,0,0]
["YM-201627","YM-201627","C512723",0,0,2,0,0,0,0]
["YM-231146","YM-231146","C506332",0,0,2,1,0,0,0]
["YM-359445","YM-359445","C509950",0,0,2,1,0,0,0]
["Yohimbine","Yohimbine","D015016",16,4,2,0,8,0,0]
["yomogin","yomogin","C117320",0,0,2,0,2,0,0]
["yonkenafil","yonkenafil","C000613072",2,0,0,0,0,0,0]
["YO-PRO 1","YO-PRO 1","C089813",0,0,0,0,6,0,0]
["yoropyrazone","yoropyrazone","C573846",0,0,0,0,2,0,0]
["Yoshixol","Yoshixol","C107152",0,0,0,0,3,0,0]
["yougui","yougui","C552041",0,0,0,0,1,0,0]
["you-gui-wan","you-gui-wan","C502768",0,3,1,0,0,0,0]
["YoYo-3","YoYo-3","C412625",2,0,0,0,0,0,0]
["YS 49","YS 49","C090309",0,0,1,0,4,0,0]
["YS 822A","YS 822A","C066092",2,0,0,0,0,0,0]
["YSK 2821","YSK 2821","C531032",0,2,2,0,2,0,0]
["YSK05","YSK05","C580570",10,0,0,0,0,0,0]
["YSL-12","YSL-12","C000613984",0,0,2,0,2,0,0]
["ytterbium(III)-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid 10-o-aminoanilide","ytterbium(III)-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid 10-o-aminoanilide","C572942",4,0,0,0,0,0,0]
["ytterbium-tetramethyl-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid","ytterbium-tetramethyl-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid","C101405",2,0,0,0,0,0,0]
["yttrium(III)-1,4,7,10-tetraazacyclotetradecane-N,N',N'',N'''-tetraacetic acid","yttrium(III)-1,4,7,10-tetraazacyclotetradecane-N,N',N'',N'''-tetraacetic acid","C113625",2,0,0,0,0,0,0]
["yu ping feng san","yu ping feng san","C506362",0,0,3,0,2,0,0]
["Yuanhuacin","Yuanhuacin","C029912",0,0,4,0,2,0,0]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C25732,B25732)","v":"Yuanhuagine"},"Yuanhuagine","C512332",0,0,2,0,0,0,0]
["yuchangning","yuchangning","C534052",2,0,0,0,0,0,0]
["yunnanterpene D","yunnanterpene D","C582815",0,0,2,0,0,0,0]
["yunnanterpene E","yunnanterpene E","C582816",0,0,2,0,0,0,0]
["yupingfeng","yupingfeng","C532967",0,0,8,0,0,0,0]
["YXM110","YXM110","C000609610",0,0,2,0,2,0,0]
["Z 338","Z 338","C410959",2,1,0,0,0,0,0]
["Z-10 nitro compound","Z-10 nitro compound","C000621791",0,0,0,0,2,0,0]
["Z-360","Z-360","C528831",0,0,4,0,2,0,0]
["zabofloxacin","zabofloxacin","C480202",0,1,0,0,0,0,0]
["zacopride","zacopride","C055971",4,0,0,0,0,0,0]
["zafirlukast","zafirlukast","C062735",6,4,0,0,1,0,0]
["zaleplon","zaleplon","C085665",4,1,0,0,0,0,0]
["zaluzanin-D","zaluzanin-D","C474047",0,0,0,0,2,0,0]
["zampanolide","zampanolide","C444900",0,0,8,0,2,0,0]
["zapotin","zapotin","C517807",0,0,0,0,7,0,0]
["zaprinast","zaprinast","C011145",2,0,2,0,6,0,0]
["zaragozic acid B","zaragozic acid B","C079089",2,0,0,0,0,0,0]
["zardaverine","zardaverine","C066436",0,0,2,0,2,0,0]
["zatebradine","zatebradine","C043636",2,0,0,0,0,0,0]
["ZB716 compound","ZB716 compound","C000621128",0,0,2,0,0,0,0]
["ZBB-006","ZBB-006","C557212",0,0,0,0,2,0,0]
["ZBH-1205","ZBH-1205","C000618348",0,0,0,0,1,0,0]
["ZCR 2060","ZCR 2060","C091433",0,2,0,0,0,0,0]
["ZCVI4-2","ZCVI4-2","C561136",4,0,0,0,0,0,0]
["ZD 2767","ZD 2767","C097602",0,0,0,0,1,0,0]
["ZD 4190","ZD 4190","C405268",0,0,3,3,0,0,0]
["ZD 9331","ZD 9331","C094299",0,0,2,0,4,0,0]
["ZD4054","ZD4054","C511404",0,0,10,3,6,0,0]
["Ze 450","Ze 450","C510722",0,0,2,0,0,0,0]
["zearalenol","zearalenol","C029659",2,1,11,0,18,1,0]
["Zearalenone","Zearalenone","D015025",54,11,80,4,132,4,0]
["Zeatin","Zeatin","D015026",2,0,0,0,0,0,0]
["zeaxanthin dipalmitate","zeaxanthin dipalmitate","C109854",0,0,0,0,2,0,0]
["zederone","zederone","C586942",0,2,0,0,0,0,0]
["zedoarondiol","zedoarondiol","C546347",0,0,2,0,2,0,0]
["Zeneca ZD 6169","Zeneca ZD 6169","C095007",2,0,0,0,0,0,0]
["zengmian yiliu","zengmian yiliu","C000601926",0,0,0,0,1,0,0]
["zephiramine","zephiramine","C005883",6,0,0,0,0,0,0]
["Zeranol","Zeranol","D015029",2,2,27,0,26,1,0]
["zerumbone","zerumbone","C403304",2,0,34,3,68,0,0]
["zetidoline","zetidoline","C027277",2,0,0,0,0,0,0]
["zhankuic acid A","zhankuic acid A","C098367",0,0,1,0,2,0,0]
["zhen-wu-tang","zhen-wu-tang","C560527",0,0,0,0,2,0,0]
["zhibai dihuang","zhibai dihuang","C540472",0,0,1,0,4,0,0]
["zhikang capsule","zhikang capsule","C000617393",0,0,0,0,2,0,0]
["ziconotide","ziconotide","C078452",2,1,0,0,0,1,0]
["zilascorb","zilascorb","C070680",4,3,0,0,19,0,0]
["zileuton","zileuton","C063449",2,1,10,0,11,0,0]
["zilongjin","zilongjin","C558114",0,0,6,0,5,0,0]
["Zilpaterol","Zilpaterol","C475840",10,0,2,0,0,0,0]
["zinc 1,4,8,11,15,18,22,25-octa-n-butoxyphthalocyanine","zinc 1,4,8,11,15,18,22,25-octa-n-butoxyphthalocyanine","C061188",0,1,0,0,2,0,0]
["Zinc Acetate","Zinc Acetate","D019345",10,1,1,0,6,0,0]
["zinc chlorin","zinc chlorin","C558702",2,0,0,0,0,0,0]
["zinc fluoride","zinc fluoride","C038904",4,0,0,0,2,0,0]
["zinc gluconate arginine","zinc gluconate arginine","C482583",0,2,0,0,0,0,0]
["zinc hydroxide","zinc hydroxide","C052745",12,0,2,0,0,1,0]
["zinc iodide","zinc iodide","C029770",2,0,0,0,0,0,0]
["zinc meso-tetrakis(1-methylpyridinium-4-yl)porphyrin chloride","zinc meso-tetrakis(1-methylpyridinium-4-yl)porphyrin chloride","C000590154",2,0,0,0,0,0,0]
["zinc monoglycerolate","zinc monoglycerolate","C067226",2,0,0,0,0,0,0]
["zinc nitrate","zinc nitrate","C042103",6,0,0,0,0,0,0]
["zinc octabutoxyphthalocyanine","zinc octabutoxyphthalocyanine","C562089",2,0,0,0,0,0,0]
["Zinc Oxide-Eugenol Cement","Zinc Oxide-Eugenol Cement","D015035",22,7,16,0,2,0,0]
["zinc oxide-non-eugenol cement","zinc oxide-non-eugenol cement","C449162",0,0,2,0,0,0,0]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C25796,B25796)","v":"zinc phosphate"},"zinc phosphate","C043952",14,0,2,0,0,0,0]
["Zinc Phosphate Cement","Zinc Phosphate Cement","D015036",48,0,0,0,0,0,0]
["zinc phthalocyanine disulfonate","zinc phthalocyanine disulfonate","C064329",0,1,0,0,4,0,0]
["zinc phthalocyanine sulfonate","zinc phthalocyanine sulfonate","C064328",0,0,0,0,2,0,0]
["zinc protoporphyrin","zinc protoporphyrin","C017803",12,2,8,2,22,0,0]
["zinc selenide","zinc selenide","C044696",28,0,1,0,0,0,0]
["zinc silicate","zinc silicate","C029500",2,0,2,0,0,0,0]
["zinc sulfide","zinc sulfide","C031238",122,1,10,0,10,0,0]
["zinc tetra(4-N-methylpyridyl)porphine","zinc tetra(4-N-methylpyridyl)porphine","C060088",0,0,0,0,1,0,0]
["zinc tetrasulfophthalocyanine","zinc tetrasulfophthalocyanine","C052735",4,2,0,0,2,1,0]
["zinc(II) dipicolylamine","zinc(II) dipicolylamine","C509592",0,0,2,0,3,0,0]
["zinc(II) phthalocyanine trisulfonic acid","zinc(II) phthalocyanine trisulfonic acid","C063072",0,0,7,0,7,0,0]
["zinc(II)-octadecyl-phthalocyanine","zinc(II)-octadecyl-phthalocyanine","C114656",0,1,0,0,1,0,0]
["ZINC32101539","ZINC32101539","C000612733",0,0,2,0,0,0,0]
["ZINC33468944","ZINC33468944","C000612732",0,0,2,0,0,0,0]
["ZINC69391","ZINC69391","C000595961",0,0,2,0,0,0,0]
["zinc-desferrioxamine","zinc-desferrioxamine","C086228",0,1,0,0,0,0,0]
["zinc-tetrakis(p-sulfonatophenyl)porphyrin","zinc-tetrakis(p-sulfonatophenyl)porphyrin","C474512",0,0,0,0,2,0,0]
["Zineb","Zineb","D015038",16,1,4,0,19,2,0]
["zingerone","zingerone","C013738",0,0,2,1,10,0,0]
["zingiberene","zingiberene","C477983",2,0,2,0,0,0,0]
["zinniol","zinniol","C051798",0,1,0,0,0,0,0]
["Zinostatin","Zinostatin","D009353",51,6,4,1,17,5,0]
["zinpyr-1","zinpyr-1","C501987",6,0,0,0,0,0,0]
["Zinpyr-4","Zinpyr-4","C501988",2,0,0,0,0,0,0]
["zinquin","zinquin","C084731",4,1,0,0,1,0,0]
["zinterol","zinterol","C002904",0,0,0,0,2,0,0]
["Zionomer","Zionomer","C070891",2,0,0,0,0,0,0]
["zipeprol","zipeprol","C013341",2,0,0,0,0,0,0]
["ziprasidone","ziprasidone","C092292",12,3,6,0,0,0,0]
["Ziram","Ziram","D015039",2,5,0,0,10,0,0]
["zirconium hydrogen monothiophosphate","zirconium hydrogen monothiophosphate","C545302",2,0,0,0,0,0,0]
["zirconyl hematoxylin","zirconyl hematoxylin","C418048",6,0,0,0,0,0,0]
["Zishen Yutai","Zishen Yutai","C000615671",0,1,0,0,0,0,0]
["ziyuglycoside I","ziyuglycoside I","C484848",0,0,2,0,4,0,0]
["ziyuglycoside II","ziyuglycoside II","C000588918",0,0,4,1,6,0,0]
["ZJ-101","ZJ-101","C000621213",0,0,4,0,0,0,0]
["Zj6413","Zj6413","C000609887",0,0,2,0,2,0,0]
["ZK 191784","ZK 191784","C470666",0,0,2,0,0,0,0]
["ZK 93426","ZK 93426","C042568",2,0,0,0,0,0,0]
["ZK159222","ZK159222","C410228",0,0,2,0,0,0,0]
["ZK60 magnesium alloy","ZK60 magnesium alloy","C586529",4,0,0,0,0,0,0]
["ZL-004","ZL-004","C571930",0,0,2,0,0,0,0]
["ZLD1039","ZLD1039","C000613153",0,0,2,0,2,0,0]
["ZLD10A compound","ZLD10A compound","C000613814",0,0,2,0,2,0,0]
["ZLJ33 compound","ZLJ33 compound","C000595659",0,0,2,0,0,0,0]
["ZLM-7 compound","ZLM-7 compound","C000613742",0,0,2,1,0,0,0]
["ZLN005","ZLN005","C581161",0,0,0,0,2,0,0]
["ZM 241385","ZM 241385","C097270",0,0,2,0,0,1,0]
["ZM323881","ZM323881","C478783",0,0,0,1,0,0,0]
["ZM-66 compound","ZM-66 compound","C000593067",0,0,2,0,2,0,0]
["Zn(cyclen)(lumazine)","Zn(cyclen)(lumazine)","C482467",2,0,0,0,0,0,0]
["Zn(II)-DpaTyr","Zn(II)-DpaTyr","C521584",2,0,0,0,0,0,0]
["Zn(II)-phthalocyanine","Zn(II)-phthalocyanine","C052159",10,15,16,0,48,0,0]
["ZnAF-1","ZnAF-1","C462060",2,0,0,0,0,0,0]
["ZnAF-2","ZnAF-2","C462061",2,0,0,0,0,0,0]
["Zn-BC-AM","Zn-BC-AM","C497948",0,0,1,0,4,0,0]
["ZnPc(COOH)16","ZnPc(COOH)16","C549929",0,0,0,0,2,0,0]
["zoanthenol","zoanthenol","C457061",0,0,2,0,0,0,0]
["Zolazepam","Zolazepam","D015041",19,0,0,0,0,0,0]
["zoledronic acid","zoledronic acid","C088658",12,15,378,28,378,0,0]
["zolpidem","zolpidem","C049109",10,1,2,0,0,1,0]
["zomepirac","zomepirac","C020549",12,0,0,0,0,0,0]
["zomepirac glucuronide","zomepirac glucuronide","C027368",6,0,0,0,0,0,0]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C25860,B25860)","v":"Zonarol"},"Zonarol","C000603465",0,0,0,0,2,0,0]
["zoniclezole","zoniclezole","C078649",2,0,0,0,0,0,0]
["zoniporide","zoniporide","C424422",0,2,0,0,2,0,0]
["zonisamide","zonisamide","C022189",11,2,0,0,6,0,0]
["Zonyl","Zonyl","C038646",2,0,0,0,0,0,0]
["zopfiellin","zopfiellin","C470145",2,0,0,0,0,0,0]
["zopiclone","zopiclone","C515050",12,1,0,0,0,0,0]
["zopiclone N-oxide","zopiclone N-oxide","C053228",2,0,0,0,0,0,0]
["zopolrestat","zopolrestat","C067172",4,0,0,2,2,0,0]
["zorubicin","zorubicin","C002205",2,0,0,0,0,0,0]
["zosuquidar trihydrochloride","zosuquidar trihydrochloride","C095179",0,0,0,0,2,0,0]
["zotarolimus","zotarolimus","C489443",0,2,16,0,5,0,0]
["Zoxazolamine","Zoxazolamine","D015049",4,2,0,0,0,0,0]
["ZP-CT-A compound","ZP-CT-A compound","C512934",0,0,1,0,0,0,0]
["ZR 2003","ZR 2003","C570100",0,0,4,0,2,0,0]
["ZR2002","ZR2002","C493478",0,0,2,0,2,0,0]
["ZRBA1 compound","ZRBA1 compound","C503825",0,0,4,0,5,0,0]
["ZRF4 compound","ZRF4 compound","C562198",0,0,2,0,0,0,0]
["ZS-9 compound","ZS-9 compound","C000597310",2,0,0,0,0,0,0]
["ZSM-5 zeolite","ZSM-5 zeolite","C570564",4,0,1,0,0,0,0]
["ZSTK474","ZSTK474","C510150",0,0,28,2,13,0,0]
["ZT-25 compound","ZT-25 compound","C000611678",0,0,0,0,2,0,0]
["zuogui","zuogui","C552040",0,0,5,0,0,0,0]
["zuojin","zuojin","C545320",0,0,0,0,2,0,0]
["Zuo-Jin-Wan","Zuo-Jin-Wan","C560510",0,0,0,0,4,0,0]
["zwittergent 3-12","zwittergent 3-12","C034730",8,0,0,0,0,0,0]
["ZXHA-TC compound","ZXHA-TC compound","C000622577",0,0,2,0,0,0,0]
["ZY-1 compound","ZY-1 compound","C000588574",0,0,2,0,0,0,0]
["ZYD88 herbal formula","ZYD88 herbal formula","C483847",0,0,2,1,2,0,0]
["Zyflamend","Zyflamend","C519312",0,0,13,0,10,1,0]
["Zymosan","Zymosan","D015054",28,3,9,1,5,0,0]
["zymosterol","zymosterol","C015582",2,0,1,0,0,0,0]

{"sheet":"Detail","index":1,"n_rows":343946,"n_cols":18,"rows_kept":4500,"cut":true,"hidden":false,"merged":[],"bounds":{"rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0}}
["Detail - AOP "]
["Chemical MeSH Name (hyperlinked)","ChemName","chemuid","catord","event_id","event_order","Event Process","Event Action","MeSH term (hyperlinked)","uid","MeSHterm","basescore","Score","Pub Yr","pmid","Title","LinkPMID","aop_id"]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C3,B3)","v":"(((4-(ethoxycarbonyl)phenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methan-1-one"},"(((4-(ethoxycarbonyl)phenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methan-1-one","C508274","5_KE",768,5,"Cytotoxicity","Increase",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J3,K3)","v":"Apoptosis"},"D017209","Apoptosis",1,1,2005,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q3,Q3)","v":"16133793"},"Flexible heteroarotinoids (Flex-Hets) exhibit improved therapeutic ratios as anti-cancer agents over retinoic acid receptor agonists.","16133793",136]
["(((4-(ethoxycarbonyl)phenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methan-1-one","(((4-(ethoxycarbonyl)phenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methan-1-one","C508274","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2005,"16133793","Flexible heteroarotinoids (Flex-Hets) exhibit improved therapeutic ratios as anti-cancer agents over retinoic acid receptor agonists.","16133793",136]
["(((4-(ethoxycarbonyl)phenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methane-1-thione","(((4-(ethoxycarbonyl)phenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methane-1-thione","C508275","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2005,"16133793","Flexible heteroarotinoids (Flex-Hets) exhibit improved therapeutic ratios as anti-cancer agents over retinoic acid receptor agonists.","16133793",136]
["(((4-(ethoxycarbonyl)phenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methane-1-thione","(((4-(ethoxycarbonyl)phenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methane-1-thione","C508275","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2005,"16133793","Flexible heteroarotinoids (Flex-Hets) exhibit improved therapeutic ratios as anti-cancer agents over retinoic acid receptor agonists.","16133793",136]
["(((4-nitrophenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methane-1-thione","(((4-nitrophenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methane-1-thione","C476105","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2003,"12839980","The synthetic heteroarotinoid SHetA2 induces apoptosis in squamous carcinoma cells through a receptor-independent and mitochondria-dependent pathway.","12839980",136]
["(((4-nitrophenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methane-1-thione","(((4-nitrophenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methane-1-thione","C476105","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2005,"16133793","Flexible heteroarotinoids (Flex-Hets) exhibit improved therapeutic ratios as anti-cancer agents over retinoic acid receptor agonists.","16133793",136]
["(((4-nitrophenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methane-1-thione","(((4-nitrophenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methane-1-thione","C476105","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2008,"18593935","CAAT/enhancer binding protein homologous protein-dependent death receptor 5 induction is a major component of SHetA2-induced apoptosis in lung cancer cells.","18593935",136]
["(((4-nitrophenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methane-1-thione","(((4-nitrophenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methane-1-thione","C476105","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2008,"19001438","Involvement of c-FLIP and survivin down-regulation in flexible heteroarotinoid-induced apoptosis and enhancement of TRAIL-initiated apoptosis in lung cancer cells.","19001438",136]
["(((4-nitrophenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methane-1-thione","(((4-nitrophenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methane-1-thione","C476105","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2009,"19417155","Development of flexible-heteroarotinoids for kidney cancer.","19417155",136]
["(((4-nitrophenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methane-1-thione","(((4-nitrophenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methane-1-thione","C476105","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2009,"19804900","Induction of death receptor ligand-mediated apoptosis in epithelial ovarian carcinoma: The search for sensitizing agents.","19804900",136]
["(((4-nitrophenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methane-1-thione","(((4-nitrophenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methane-1-thione","C476105","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2010,"20032777","NF-kappaB is involved in SHetA2 circumvention of TNF-alpha resistance, but not induction of intrinsic apoptosis.","20032777",136]
["(((4-nitrophenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methane-1-thione","(((4-nitrophenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methane-1-thione","C476105","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28844711","Novel flexible heteroarotinoid, SL-1-18, promotes ERα degradation to inhibit breast cancer cell growth.","28844711",136]
["(((4-nitrophenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methane-1-thione","(((4-nitrophenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methane-1-thione","C476105","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2005,"16133793","Flexible heteroarotinoids (Flex-Hets) exhibit improved therapeutic ratios as anti-cancer agents over retinoic acid receptor agonists.","16133793",136]
["(((4-nitrophenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methane-1-thione","(((4-nitrophenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methane-1-thione","C476105","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"18802666","Flexible heteroarotinoid (Flex-Het) SHetA2 inhibits angiogenesis in vitro and in vivo.","18802666",136]
["(((4-nitrophenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methane-1-thione","(((4-nitrophenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methane-1-thione","C476105","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25880346","Synthesis and evaluation of second generation Flex-Het scaffolds against the human ovarian cancer A2780 cell line.","25880346",136]
["(((4-nitrophenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methane-1-thione","(((4-nitrophenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methane-1-thione","C476105","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28844711","Novel flexible heteroarotinoid, SL-1-18, promotes ERα degradation to inhibit breast cancer cell growth.","28844711",136]
["(((4-nitrophenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methane-1-thione","(((4-nitrophenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methane-1-thione","C476105","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2009,"18802666","Flexible heteroarotinoid (Flex-Het) SHetA2 inhibits angiogenesis in vitro and in vivo.","18802666",136]
["(((4-nitrophenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methane-1-thione","(((4-nitrophenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methane-1-thione","C476105","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2013,"23852423","Chemoprevention of colon and small intestinal tumorigenesis in APC(min/+) mice by SHetA2 (NSC721689) without toxicity.","23852423",136]
["((-)-7-(3-amino-1-azetidinyl)-8-chloro-1-cyclopropyl-1,4-dihydro-6-fluoro-4-oxo-3-quinolinecarboxylic acid)","((-)-7-(3-amino-1-azetidinyl)-8-chloro-1-cyclopropyl-1,4-dihydro-6-fluoro-4-oxo-3-quinolinecarboxylic acid)","C444451","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2001,"11600365","Antibacterial activities and pharmacokinetics of E-4767 and E-5065, two new 8-chlorofluoroquinolones with a 7-azetidin ring substituent.","11600365",136]
["((-)-7-(3-amino-2-methyl-1-azetidinyl)-8-chloro-1-cyclopropyl-1,4-dihydro-6-fluoro-4-oxo-3-quinolinecarboxylic acid)","((-)-7-(3-amino-2-methyl-1-azetidinyl)-8-chloro-1-cyclopropyl-1,4-dihydro-6-fluoro-4-oxo-3-quinolinecarboxylic acid)","C444450","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2001,"11600365","Antibacterial activities and pharmacokinetics of E-4767 and E-5065, two new 8-chlorofluoroquinolones with a 7-azetidin ring substituent.","11600365",136]
["((1R,2R)-1,2-diaminocyclohexane)platinum(II)","((1R,2R)-1,2-diaminocyclohexane)platinum(II)","C554217","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"22195780","New polymer-platinum (II) antitumor conjugates.","22195780",136]
["((1R,2R)-1,2-diaminocyclohexane)platinum(II)","((1R,2R)-1,2-diaminocyclohexane)platinum(II)","C554217","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2011,"22195780","New polymer-platinum (II) antitumor conjugates.","22195780",136]
["((1S)-1-((((1S)-1-benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl)-3-methylbutyl)carbamic acid 5-methoxy-3-oxapentyl ester","((1S)-1-((((1S)-1-benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl)-3-methylbutyl)carbamic acid 5-methoxy-3-oxapentyl ester","C515164","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"20823194","Calpain inhibitor protects cells against light-induced retinal degeneration.","20823194",136]
["((1S)-1-((((1S)-1-benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl)-3-methylbutyl)carbamic acid 5-methoxy-3-oxapentyl ester","((1S)-1-((((1S)-1-benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl)-3-methylbutyl)carbamic acid 5-methoxy-3-oxapentyl ester","C515164","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"21709005","Calpain inhibition restores basal autophagy and suppresses MNU-induced photoreceptor cell death in mice.","21709005",136]
["((1S)-1-((((1S)-1-benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl)-3-methylbutyl)carbamic acid 5-methoxy-3-oxapentyl ester","((1S)-1-((((1S)-1-benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl)-3-methylbutyl)carbamic acid 5-methoxy-3-oxapentyl ester","C515164","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24447070","Effects of a novel orally administered calpain inhibitor SNJ-1945 on immunomodulation and neurodegeneration in a murine model of multiple sclerosis.","24447070",136]
["((2,3,7,8,12,13,17,18-octakis(benzylthio)-5,10,15,20-tetraazaporphyrin))nickel(II)","((2,3,7,8,12,13,17,18-octakis(benzylthio)-5,10,15,20-tetraazaporphyrin))nickel(II)","C488536","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2004,"15200384","Fabrication of PVC based membrane using nickel porphyrazine as ionophore in the screening of thiocyanate ion in aqueous and real samples.","15200384",136]
["((2,6-bis(1-methylethyl)phenoxy)sulfonyl)carbamic acid 2,6-bis(1-methylethyl)phenyl ester","((2,6-bis(1-methylethyl)phenoxy)sulfonyl)carbamic acid 2,6-bis(1-methylethyl)phenyl ester","C086204","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1994,"8126693","Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 6. The first water-soluble ACAT inhibitor with lipid-regulating activity.","8126693",136]
["((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)","((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)","C478479","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2003,"14500382","A novel small molecule met inhibitor induces apoptosis in cells transformed by the oncogenic TPR-MET tyrosine kinase.","14500382",136]
["((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)","((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)","C478479","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2009,"19502802","Cancer cells harboring MET gene amplification activate alternative signaling pathways to escape MET inhibition but remain sensitive to Hsp90 inhibitors.","19502802",136]
["((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)","((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)","C478479","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"20370683","Inhibition of c-Met with the specific small molecule tyrosine kinase inhibitor SU11274 decreases growth and metastasis formation of experimental human melanoma.","20370683",136]
["((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)","((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)","C478479","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2011,"21057531","Inhibition of c-Met downregulates TIGAR expression and reduces NADPH production leading to cell death.","21057531",136]
["((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)","((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)","C478479","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"21575221","Inhibition of phosphorylated c-Met in rhabdomyosarcoma cell lines by a small molecule inhibitor SU11274.","21575221",136]
["((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)","((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)","C478479","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"21654317","PTEN reconstitution alters glioma responses to c-Met pathway inhibition.","21654317",136]
["((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)","((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)","C478479","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23527257","Synergistic effect of afatinib with su11274 in non-small cell lung cancer cells resistant to gefitinib or erlotinib.","23527257",136]
["((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)","((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)","C478479","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27175734","Tyrosine kinase inhibitor SU11274 increased tumorigenicity and enriched for melanoma-initiating cells by bioenergetic modulation.","27175734",136]
["((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)","((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)","C478479","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2008,"18021219","Effect of a c-Met-specific, ATP-competitive small-molecule inhibitor SU11274 on human ovarian carcinoma cell growth, motility, and invasion.","18021219",136]
["((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)","((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)","C478479","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20164465","MET oncogene inhibition as a potential target of therapy for uveal melanomas.","20164465",136]
["((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)","((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)","C478479","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20370683","Inhibition of c-Met with the specific small molecule tyrosine kinase inhibitor SU11274 decreases growth and metastasis formation of experimental human melanoma.","20370683",136]
["((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)","((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)","C478479","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21057531","Inhibition of c-Met downregulates TIGAR expression and reduces NADPH production leading to cell death.","21057531",136]
["((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)","((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)","C478479","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21572247","Effect of c-Met inhibitor SU11274 on hepatocellular carcinoma cell growth.","21572247",136]
["((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)","((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)","C478479","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21575221","Inhibition of phosphorylated c-Met in rhabdomyosarcoma cell lines by a small molecule inhibitor SU11274.","21575221",136]
["((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)","((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)","C478479","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21654317","PTEN reconstitution alters glioma responses to c-Met pathway inhibition.","21654317",136]
["((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)","((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)","C478479","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23876900","Effect of c-Met inhibitor SU11274 on human colon cancer cell growth.","23876900",136]
["((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)","((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)","C478479","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"24033536","Combined γ-tocotrienol and Met inhibitor treatment suppresses mammary cancer cell proliferation, epithelial-to-mesenchymal transition and migration.","24033536",136]
["((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)","((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)","C478479","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27175734","Tyrosine kinase inhibitor SU11274 increased tumorigenicity and enriched for melanoma-initiating cells by bioenergetic modulation.","27175734",136]
["((5-nitrofuran-2-yl)methyl-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenyl 4-chlorobutyl(methyl)phosphoramidate)","((5-nitrofuran-2-yl)methyl-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenyl 4-chlorobutyl(methyl)phosphoramidate)","C548776","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2010,"20086055","A novel geranylgeranyl transferase inhibitor in combination with lovastatin inhibits proliferation and induces autophagy in STS-26T MPNST cells.","20086055",136]
["((5-nitrofuran-2-yl)methyl-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenyl 4-chlorobutyl(methyl)phosphoramidate)","((5-nitrofuran-2-yl)methyl-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenyl 4-chlorobutyl(methyl)phosphoramidate)","C548776","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20086055","A novel geranylgeranyl transferase inhibitor in combination with lovastatin inhibits proliferation and induces autophagy in STS-26T MPNST cells.","20086055",136]
["((5Z)5-(1,3-benzodioxol-5-yl)methylene-2-phenylamino-3,5-dihydro-4H-imidazol-4-one)","((5Z)5-(1,3-benzodioxol-5-yl)methylene-2-phenylamino-3,5-dihydro-4H-imidazol-4-one)","C578491","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"26381812","Leucettine L41, a DYRK1A-preferential DYRKs/CLKs inhibitor, prevents memory impairments and neurotoxicity induced by oligomeric Aβ25-35 peptide administration in mice.","26381812",136]
["((7-chloroquinolin-4-yl)amino)chalcone","((7-chloroquinolin-4-yl)amino)chalcone","C587511","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23871905","Synthesis of novel analogs of 2-pyrazoline obtained from [(7-chloroquinolin-4-yl)amino]chalcones and hydrazine as potential antitumor and antimalarial agents.","23871905",136]
["((diethylenetriamine)copper(II)(mu-imidazolate)copper(II)(diethylenetriamine)) perchlorate","((diethylenetriamine)copper(II)(mu-imidazolate)copper(II)(diethylenetriamine)) perchlorate","C500449","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2005,"15556452","Novel copper(II)-dien-imidazole/imidazolate-bridged copper(II) complexes. Crystal structure of [Cu(dien)(Him)](ClO4)2 and of [(dien)Cu(mu-im)Cu(dien)](ClO4)3, a homobinuclear model for the copper(II) site of the CuZn-superoxide dismutase.","15556452",136]
["((dihydroindenyl)oxy)alkanoic acid","((dihydroindenyl)oxy)alkanoic acid","C059990","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1991,"1998586","K+ efflux in deoxygenated sickle cells in the presence or absence of DIOA, a specific inhibitor of the [K+, Cl-] cotransport system.","1998586",136]
["((E)-(5)-(3,5-di-tert-butyl-4-hydroxybenzylidene)- 2-ethyl-1,2-isothiazolidine-1,1-dioxide)","((E)-(5)-(3,5-di-tert-butyl-4-hydroxybenzylidene)- 2-ethyl-1,2-isothiazolidine-1,1-dioxide)","C409872","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2005,"15996566","S-2474, a novel nonsteroidal anti-inflammatory drug, rescues cortical neurons from human group IIA secretory phospholipase A(2)-induced apoptosis.","15996566",136]
["((eta6-p-cymene)Ru(4,4,4-trifluoro-1-(4-chlorophenyl)-1,3-butanedione)-1,3,5-triaza-7-phosphaadamantane)","((eta6-p-cymene)Ru(4,4,4-trifluoro-1-(4-chlorophenyl)-1,3-butanedione)-1,3,5-triaza-7-phosphaadamantane)","C000599960","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25856666","Structure-Related Mode-of-Action Differences of Anticancer Organoruthenium Complexes with β-Diketonates.","25856666",136]
["((H2O)(terpy)Mn(mu-O)2Mn(terpy)(OH2))(NO3)3","((H2O)(terpy)Mn(mu-O)2Mn(terpy)(OH2))(NO3)3","C550429","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2010,"20372724","[(H2O)(terpy)Mn(mu-O)2Mn(terpy)(OH2)](NO3)3 (terpy = 2,2':6,2''-terpyridine) and its relevance to the oxygen-evolving complex of photosystem II examined through pH dependent cyclic voltammetry.","20372724",136]
["((N-morpholine)metylene)daunorubicin","((N-morpholine)metylene)daunorubicin","C561665","1_MIE",867,1,"Intracellular pH","Decrease","Acid-Base Equilibrium","D000136","Acid-Base Equilibrium",2,2,2012,"22124459","Acid-base catalysis of N-[(morpholine)methylene]daunorubicin.","22124459",136]
["((N-morpholine)metylene)daunorubicin","((N-morpholine)metylene)daunorubicin","C561665","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"22124459","Acid-base catalysis of N-[(morpholine)methylene]daunorubicin.","22124459",136]
["((N-piperidine)methylene)daunorubicin hydrochloride","((N-piperidine)methylene)daunorubicin hydrochloride","C000592427","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"24688433","The influence of pH and temperature on the stability of N-[(piperidine)methylene]daunorubicin Hydrochloride and a comparison of the stability of daunorubicin and its four new amidine derivatives in aqueous solutions.","24688433",136]
["((Py-3')TPP-Ru(phen)2Cl)Cl","((Py-3')TPP-Ru(phen)2Cl)Cl","C547322","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2010,"19958751","DNA binding and photocleavage properties and apoptosis-inducing activities of a ruthenium porphyrin complex [(Py-3')TPP-Ru(phen)2Cl]Cl and its heterometallic derivatives.","19958751",136]
["((S)-2-acetylamino-3-((R)-(1-(3-(piperidin-4-yl)propionyl)piperidin-3-ylcarbonyl))amino) propionic acid trihydrate","((S)-2-acetylamino-3-((R)-(1-(3-(piperidin-4-yl)propionyl)piperidin-3-ylcarbonyl))amino) propionic acid trihydrate","C496616","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2004,"15363977","Apoptotic activity of betulinic acid derivatives on murine melanoma B16 cell line.","15363977",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","3_KE",870,3,"Cell Proliferation","Increase","Airway Remodeling","D056151","Airway Remodeling",2,3,2017,"29237530","[Mechanism of action of BET bromodomain inhibitor JQ1 in treating airway remodeling in asthmatic mice].","29237530",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2012,"22904298","BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia.","22904298",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2012,"23249862","Small-molecule inhibition of BRD4 as a new potent approach to eliminate leukemic stem- and progenitor cells in acute myeloid leukemia AML.","23249862",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"24045185","Efficacy of BET bromodomain inhibition in Kras-mutant non-small cell lung cancer.","24045185",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25009295","Inhibition of bromodomain proteins for the treatment of human diffuse large B-cell lymphoma.","25009295",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C67,B67)","v":"(+)-JQ1 compound"},"(+)-JQ1 compound","C561695","5_KE",768,5,"Cytotoxicity","Increase",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J67,K67)","v":"Apoptosis"},"D017209","Apoptosis",1,2,2014,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q67,Q67)","v":"25053825"},"BET protein antagonist JQ1 is synergistically lethal with FLT3 tyrosine kinase inhibitor (TKI) and overcomes resistance to FLT3-TKI in AML cells expressing FLT-ITD.","25053825",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25307878","Synergistic effect of JQ1 and rapamycin for treatment of human osteosarcoma.","25307878",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2015,"25762632","JQ1 suppresses tumor growth through downregulating LDHA in ovarian cancer.","25762632",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"25961927","The BET bromodomain inhibitor JQ1 suppresses growth of pancreatic ductal adenocarcinoma in patient-derived xenograft models.","25961927",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"26051217","Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4.","26051217",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"26067464","Bromodomain and extraterminal inhibition blocks tumor progression and promotes differentiation in neuroblastoma.","26067464",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"26415225","The BET bromodomain inhibitor, JQ1, facilitates c-FLIP degradation and enhances TRAIL-induced apoptosis independent of BRD4 and c-Myc inhibition.","26415225",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"26485762","SMAC mimetic Debio 1143 synergizes with taxanes, topoisomerase inhibitors and bromodomain inhibitors to impede growth of lung adenocarcinoma cells.","26485762",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"26575167","Suppression of BRD4 inhibits human hepatocellular carcinoma by repressing MYC and enhancing BIM expression.","26575167",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"26623725","Targeting the EWS-ETS transcriptional program by BET bromodomain inhibition in Ewing sarcoma.","26623725",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"26733615","The Bromodomain Inhibitor JQ1 and the Histone Deacetylase Inhibitor Panobinostat Synergistically Reduce N-Myc Expression and Induce Anticancer Effects.","26733615",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2016,"26830473","BET protein inhibitor JQ1 inhibits growth and modulates WNT signaling in mesenchymal stem cells.","26830473",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"26911376","MCM5 as a target of BET inhibitors in thyroid cancer cells.","26911376",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27006472","Targeting the epigenetic readers in Ewing sarcoma inhibits the oncogenic transcription factor EWS/Fli1.","27006472",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27055867","BET inhibition represses miR17-92 to drive BIM-initiated apoptosis of normal and transformed hematopoietic cells.","27055867",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27259267","BET inhibition as a new strategy for the treatment of gastric cancer.","27259267",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27406984","BET Inhibition Induces Apoptosis in Aggressive B-Cell Lymphoma via Epigenetic Regulation of BCL-2 Family Members.","27406984",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27572308","JQ1 suppresses tumor growth via PTEN/PI3K/AKT pathway in endometrial cancer.","27572308",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27573714","JQ1, a small molecule inhibitor of BRD4, suppresses cell growth and invasion in oral squamous cell carcinoma.","27573714",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28356707","Epigenetic intervention with a BET inhibitor ameliorates acute retinal ganglion cell death in mice.","28356707",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27764802","MYCL is a target of a BET bromodomain inhibitor, JQ1, on growth suppression efficacy in small cell lung cancer cells.","27764802",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27775715","Design and characterization of bivalent BET inhibitors.","27775715",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"27864418","AMPK-ULK1-Mediated Autophagy Confers Resistance to BET Inhibitor JQ1 in Acute Myeloid Leukemia Stem Cells.","27864418",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28026145","The bromodomain inhibitor JQ1 triggers growth arrest and apoptosis in testicular germ cell tumours in vitro and in vivo.","28026145",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28059436","The BET Bromodomain Inhibitor JQ1 Suppresses Chondrosarcoma Cell Growth via Regulation of YAP/p21/c-Myc Signaling.","28059436",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28100396","Small molecules remain on target for c-Myc.","28100396",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28100400","Replication Study: BET bromodomain inhibition as a therapeutic strategy to target c-Myc.","28100400",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28391274","Inhibition of BRD4 Suppresses Cell Proliferation and Induces Apoptosis in Renal Cell Carcinoma.","28391274",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28418907","BH3-mimetics and BET-inhibitors elicit enhanced lethality in malignant glioma.","28418907",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28576751","Targeting of super-enhancers and mutant BRAF can suppress growth of BRAF-mutant colon cancer cells via repression of MAPK signaling pathway.","28576751",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28593508","BET bromodomain inhibitor JQ1 decreases CD30 and CCR4 expression and proliferation of cutaneous T-cell lymphoma cell lines.","28593508",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"29074567","Image-based drug screen identifies HDAC inhibitors as novel Golgi disruptors synergizing with JQ1.","29074567",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"29287727","Upregulation of Mcl-1 inhibits JQ1-triggered anticancer activity in hepatocellular carcinoma cells.","29287727",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22802445","BET bromodomain inhibition as a novel strategy for reactivation of HIV-1.","22802445",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2012,"22904298","BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia.","22904298",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"23129625","Sensitivity of human lung adenocarcinoma cell lines to targeted inhibition of BET epigenetic signaling proteins.","23129625",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"23137537","BET bromodomain inhibition rescues erythropoietin differentiation of human erythroleukemia cell line UT7.","23137537",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"23249862","Small-molecule inhibition of BRD4 as a new potent approach to eliminate leukemic stem- and progenitor cells in acute myeloid leukemia AML.","23249862",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"24045185","Efficacy of BET bromodomain inhibition in Kras-mutant non-small cell lung cancer.","24045185",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25009295","Inhibition of bromodomain proteins for the treatment of human diffuse large B-cell lymphoma.","25009295",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"25277525","BET protein inhibitor JQ1 attenuates Myc-amplified MCC tumor growth in vivo.","25277525",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25307878","Synergistic effect of JQ1 and rapamycin for treatment of human osteosarcoma.","25307878",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2015,"25721606","Inhibition of BET proteins impairs estrogen-mediated growth and transcription in breast cancers by pausing RNA polymerase advancement.","25721606",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2015,"25762632","JQ1 suppresses tumor growth through downregulating LDHA in ovarian cancer.","25762632",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"26051217","Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4.","26051217",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"26253517","Sensitivity of Small Cell Lung Cancer to BET Inhibition Is Mediated by Regulation of ASCL1 Gene Expression.","26253517",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"26254443","Synergistic activity of BET protein antagonist-based combinations in mantle cell lymphoma cells sensitive or resistant to ibrutinib.","26254443",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"26378038","Induction of USP17 by combining BET and HDAC inhibitors in breast cancer cells.","26378038",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"26485762","SMAC mimetic Debio 1143 synergizes with taxanes, topoisomerase inhibitors and bromodomain inhibitors to impede growth of lung adenocarcinoma cells.","26485762",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2016,"26505118","Bromodomain and extraterminal (BET) proteins regulate biliary-driven liver regeneration.","26505118",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"26575167","Suppression of BRD4 inhibits human hepatocellular carcinoma by repressing MYC and enhancing BIM expression.","26575167",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"26623725","Targeting the EWS-ETS transcriptional program by BET bromodomain inhibition in Ewing sarcoma.","26623725",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"26733615","The Bromodomain Inhibitor JQ1 and the Histone Deacetylase Inhibitor Panobinostat Synergistically Reduce N-Myc Expression and Induce Anticancer Effects.","26733615",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"26735014","Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer.","26735014",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"26792867","BET Bromodomain Inhibitors Enhance Efficacy and Disrupt Resistance to AR Antagonists in the Treatment of Prostate Cancer.","26792867",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2016,"26830473","BET protein inhibitor JQ1 inhibits growth and modulates WNT signaling in mesenchymal stem cells.","26830473",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27081696","Epigenetic reader BRD4 inhibition as a therapeutic strategy to suppress E2F2-cell cycle regulation circuit in liver cancer.","27081696",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"26908627","The Bromodomain BET Inhibitor JQ1 Suppresses Tumor Angiogenesis in Models of Childhood Sarcoma.","26908627",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"26983878","Dual Targeting of Bromodomain and Extraterminal Domain Proteins, and WNT or MAPK Signaling, Inhibits c-MYC Expression and Proliferation of Colorectal Cancer Cells.","26983878",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27006472","Targeting the epigenetic readers in Ewing sarcoma inhibits the oncogenic transcription factor EWS/Fli1.","27006472",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27259267","BET inhibition as a new strategy for the treatment of gastric cancer.","27259267",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27259270","BET bromodomain inhibitors suppress EWS-FLI1-dependent transcription and the IGF1 autocrine mechanism in Ewing sarcoma.","27259270",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27276402","Antimyeloma activity of bromodomain inhibitors on the human myeloma cell line U266 by downregulation of MYCL.","27276402",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27432991","Loss of TRIM33 causes resistance to BET bromodomain inhibitors through MYC- and TGF-β-dependent mechanisms.","27432991",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C131,B131)","v":"(+)-JQ1 compound"},"(+)-JQ1 compound","C561695","3_KE",870,3,"Cell Proliferation","Increase",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J131,K131)","v":"Cell Proliferation"},"D049109","Cell Proliferation",1,2,2017,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q131,Q131)","v":"27440272"},"Bromodomain and Extraterminal Protein Inhibitor JQ1 Suppresses Thyroid Tumor Growth in a Mouse Model.","27440272",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"27443262","Compensatory RNA polymerase 2 loading determines the efficacy and transcriptional selectivity of JQ1 in Myc-driven tumors.","27443262",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28100396","Small molecules remain on target for c-Myc.","28100396",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28100400","Replication Study: BET bromodomain inhibition as a therapeutic strategy to target c-Myc.","28100400",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2016,"27528027","Stromal remodeling by the BET bromodomain inhibitor JQ1 suppresses the progression of human pancreatic cancer.","27528027",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27572308","JQ1 suppresses tumor growth via PTEN/PI3K/AKT pathway in endometrial cancer.","27572308",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27573714","JQ1, a small molecule inhibitor of BRD4, suppresses cell growth and invasion in oral squamous cell carcinoma.","27573714",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27581642","Structure-Activity Relationship Study of N(6)-Benzoyladenine-Type BRD4 Inhibitors and Their Effects on Cell Differentiation and TNF-α Production.","27581642",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27764802","MYCL is a target of a BET bromodomain inhibitor, JQ1, on growth suppression efficacy in small cell lung cancer cells.","27764802",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27775715","Design and characterization of bivalent BET inhibitors.","27775715",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28026145","The bromodomain inhibitor JQ1 triggers growth arrest and apoptosis in testicular germ cell tumours in vitro and in vivo.","28026145",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28059436","The BET Bromodomain Inhibitor JQ1 Suppresses Chondrosarcoma Cell Growth via Regulation of YAP/p21/c-Myc Signaling.","28059436",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28254412","Bromodomain inhibitors, JQ1 and I-BET 762, as potential therapies for pancreatic cancer.","28254412",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28805822","Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation.","28805822",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28322577","BET proteins are a key component of immunoglobulin gene expression.","28322577",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28368473","Targeting MYC as a Therapeutic Intervention for Anaplastic Thyroid Cancer.","28368473",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28391274","Inhibition of BRD4 Suppresses Cell Proliferation and Induces Apoptosis in Renal Cell Carcinoma.","28391274",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28434841","Transcriptional Dependencies in Diffuse Intrinsic Pontine Glioma.","28434841",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28545522","BRD4 inhibition suppresses cell growth, migration and invasion of salivary adenoid cystic carcinoma.","28545522",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28576751","Targeting of super-enhancers and mutant BRAF can suppress growth of BRAF-mutant colon cancer cells via repression of MAPK signaling pathway.","28576751",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28593508","BET bromodomain inhibitor JQ1 decreases CD30 and CCR4 expression and proliferation of cutaneous T-cell lymphoma cell lines.","28593508",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2015,"25762632","JQ1 suppresses tumor growth through downregulating LDHA in ovarian cancer.","25762632",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2016,"26908627","The Bromodomain BET Inhibitor JQ1 Suppresses Tumor Angiogenesis in Models of Childhood Sarcoma.","26908627",136]
["(+)-JQ1 compound","(+)-JQ1 compound","C561695","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2017,"27292261","The BET inhibitor JQ1 selectively impairs tumour response to hypoxia and downregulates CA9 and angiogenesis in triple negative breast cancer.","27292261",136]
["(1-(2-(5-(N,N-dimethylamino)naphthalenesulfonamido)ethyl)-1,4,7,10-tetraazacyclododecane)zinc(II)","(1-(2-(5-(N,N-dimethylamino)naphthalenesulfonamido)ethyl)-1,4,7,10-tetraazacyclododecane)zinc(II)","C473936","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2003,"12646703","A macrocyclic zinc(II) fluorophore as a detector of apoptosis.","12646703",136]
["(1-(3-aminophenyl)-1H-pyrrol-3-yl)(3,4,5-trimethoxyphenyl)methanone","(1-(3-aminophenyl)-1H-pyrrol-3-yl)(3,4,5-trimethoxyphenyl)methanone","C000594994","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"25025991","New pyrrole derivatives with potent tubulin polymerization inhibiting activity as anticancer agents including hedgehog-dependent cancer.","25025991",136]
["(1-(4-((4-methoxybenzyl)amino)quinazolin-2-yl)piperidin-2-yl)methanol","(1-(4-((4-methoxybenzyl)amino)quinazolin-2-yl)piperidin-2-yl)methanol","C000621119","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2016,"27505441","Discovery, Synthesis, and Evaluation of 2,4-Diaminoquinazolines as a Novel Class of Pancreatic β-Cell-Protective Agents against Endoplasmic Reticulum (ER) Stress.","27505441",136]
["(1-(4-fluorophenyl)-4a-methyl-5,6,7,8-tetrahydro-4H-benzo(f)indazol-5-yl)-(4-(trifluoromethyl)phenyl)methanol","(1-(4-fluorophenyl)-4a-methyl-5,6,7,8-tetrahydro-4H-benzo(f)indazol-5-yl)-(4-(trifluoromethyl)phenyl)methanol","C548783","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20065017","Differential in vivo effects on target pathways of a novel arylpyrazole glucocorticoid receptor modulator compared with prednisolone.","20065017",136]
["(1,10-phenanthroline)(2-phthalic acid)lanthanum(III)","(1,10-phenanthroline)(2-phthalic acid)lanthanum(III)","C510633","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2006,"16242282","Determination of bovine serum albumin by a resonance light-scattering technique with the mixed-complex La(Phth)(phen)(3+).","16242282",136]
["(1,2,4)triazolo(1,5-a)pyridinylpyridine","(1,2,4)triazolo(1,5-a)pyridinylpyridine","C587479","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23871904","Synthesis and anticancer activity evaluation of a series of [1,2,4]triazolo[1,5-a]pyridinylpyridines in vitro and in vivo.","23871904",136]
["(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane","(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane","C478160","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2003,"12963029","A novel organoselenium compound induces cell cycle arrest and apoptosis in prostate cancer cell lines.","12963029",136]
["(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane","(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane","C478160","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2003,"14703435","[Induction of apoptosis in prostate cancer cell line PC-3 by BBSKE, a novel organoselenium compound, and its effect in vivo].","14703435",136]
["(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane","(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane","C478160","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2006,"15982805","A thioredoxin reductase inhibitor induces growth inhibition and apoptosis in five cultured human carcinoma cell lines.","15982805",136]
["(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane","(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane","C478160","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2007,"17116300","The mechanism of apoptosis induced by a novel thioredoxin reductase inhibitor in A549 cells: possible involvement of nuclear factor-kappaB-dependent pathway.","17116300",136]
["(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane","(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane","C478160","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2008,"18196608","A novel thioredoxin reductase inhibitor inhibits cell growth and induces apoptosis in HL-60 and K562 cells.","18196608",136]
["(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane","(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane","C478160","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2008,"18282784","The inhibitory effect of a novel organoselenium compound BBSKE on the tongue cancer Tca8113 in vitro and in vivo.","18282784",136]
["(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane","(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane","C478160","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"25227802","Synergistic effect of ethaselen and selenite treatment against A549 human non-small cell lung cancer cells.","25227802",136]
["(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane","(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane","C478160","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27372405","Synergistic inhibition of sunitinib and ethaselen against human colorectal cancer cells proliferation.","27372405",136]
["(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane","(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane","C478160","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"27917873","Dose-biomarker-response modeling of the anticancer effect of ethaselen in a human non-small cell lung cancer xenograft mouse model.","27917873",136]
["(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane","(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane","C478160","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28471109","Ethaselen: a novel organoselenium anticancer agent targeting thioredoxin reductase 1 reverses cisplatin resistance in drug-resistant K562 cells by inducing apoptosis.","28471109",136]
["(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane","(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane","C478160","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28757135","Synergism between thioredoxin reductase inhibitor ethaselen and sodium selenite in inhibiting proliferation and inducing death of human non-small cell lung cancer cells.","28757135",136]
["(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane","(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane","C478160","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2006,"15982805","A thioredoxin reductase inhibitor induces growth inhibition and apoptosis in five cultured human carcinoma cell lines.","15982805",136]
["(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane","(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane","C478160","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2008,"18196608","A novel thioredoxin reductase inhibitor inhibits cell growth and induces apoptosis in HL-60 and K562 cells.","18196608",136]
["(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane","(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane","C478160","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2008,"18282784","The inhibitory effect of a novel organoselenium compound BBSKE on the tongue cancer Tca8113 in vitro and in vivo.","18282784",136]
["(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane","(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane","C478160","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"20195699","Thioredoxin reductase inhibitor ethaselen increases the drug sensitivity of the colon cancer cell line LoVo towards cisplatin via regulation of G1 phase and reversal of G2/M phase arrest.","20195699",136]
["(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane","(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane","C478160","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20211232","Preparation of tri-block copolymer micelles loading novel organoselenium anticancer drug BBSKE and study of tissue distribution of copolymer micelles by imaging in vivo method.","20211232",136]
["(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane","(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane","C478160","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"20864247","Novel mechanism of ethaselen in poorly differentiated colorectal RKO cell growth inhibition: Simultaneous regulation of TrxR transcription, expression and enzyme activity.","20864247",136]
["(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane","(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane","C478160","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"25227802","Synergistic effect of ethaselen and selenite treatment against A549 human non-small cell lung cancer cells.","25227802",136]
["(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane","(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane","C478160","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"26027467","Synthesis and in vitro antiproliferative evaluation of novel hybrids from 1,3,4-thiadiazole and benzisoselenazolone.","26027467",136]
["(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane","(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane","C478160","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27372405","Synergistic inhibition of sunitinib and ethaselen against human colorectal cancer cells proliferation.","27372405",136]
["(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane","(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane","C478160","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28471109","Ethaselen: a novel organoselenium anticancer agent targeting thioredoxin reductase 1 reverses cisplatin resistance in drug-resistant K562 cells by inducing apoptosis.","28471109",136]
["(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane","(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane","C478160","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28757135","Synergism between thioredoxin reductase inhibitor ethaselen and sodium selenite in inhibiting proliferation and inducing death of human non-small cell lung cancer cells.","28757135",136]
["(1,2-bis(2, 6-difluoro-3-hydroxyphenyl)ethylene-diamine)platinum(II)","(1,2-bis(2, 6-difluoro-3-hydroxyphenyl)ethylene-diamine)platinum(II)","C488612","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2004,"15188223","[1, 2-Bis(2, 6-difluoro-3-hydroxyphenyl)ethylene-diamine]platinum(II) complexes, compounds for the endocrine therapy of breast cancer - mode of action I: antitumor activity due to the reduction of the endogenous estrogen level.","15188223",136]
["(1,2-bis(6-methoxy-2H-chromen-3-yl)methylene)hydrazine","(1,2-bis(6-methoxy-2H-chromen-3-yl)methylene)hydrazine","C000596021","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"25056546","Effects of the novel compound DK223 ([1E,2E-1,2-Bis(6-methoxy-2H-chromen-3-yl)methylene]hydrazine) on migration and proliferation of human keratinocytes and primary dermal fibroblasts.","25056546",136]
["(1,2-di(cyclopentadienyl)-1,2-di(3-dimethoxyphenyl)ethanediyl)titanium dichloride","(1,2-di(cyclopentadienyl)-1,2-di(3-dimethoxyphenyl)ethanediyl)titanium dichloride","C507877","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2006,"16699961","Novel titanocene anti-cancer drugs and their effect on apoptosis and the apoptotic pathway in prostate cancer cells.","16699961",136]
["(1,2-di(cyclopentadienyl)-1,2-di(3-dimethoxyphenyl)ethanediyl)titanium dichloride","(1,2-di(cyclopentadienyl)-1,2-di(3-dimethoxyphenyl)ethanediyl)titanium dichloride","C507877","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2005,"16222151","In-vitro anti-tumor activity studies of bridged and unbridged benzyl-substituted titanocenes.","16222151",136]
["(1,2-di(cyclopentadienyl)-1,2-di(3-dimethoxyphenyl)ethanediyl)titanium dichloride","(1,2-di(cyclopentadienyl)-1,2-di(3-dimethoxyphenyl)ethanediyl)titanium dichloride","C507877","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2006,"16699961","Novel titanocene anti-cancer drugs and their effect on apoptosis and the apoptotic pathway in prostate cancer cells.","16699961",136]
["(1,2-di(cyclopentadienyl)-1,2-di(4-N,N-dimethylaminophenyl)ethanediyl)titanium dichloride","(1,2-di(cyclopentadienyl)-1,2-di(4-N,N-dimethylaminophenyl)ethanediyl)titanium dichloride","C507876","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2005,"16222151","In-vitro anti-tumor activity studies of bridged and unbridged benzyl-substituted titanocenes.","16222151",136]
["(1,2-di(cyclopentadienyl)-1,2-di(4-N,N-dimethylaminophenyl)ethanediyl)titanium dichloride","(1,2-di(cyclopentadienyl)-1,2-di(4-N,N-dimethylaminophenyl)ethanediyl)titanium dichloride","C507876","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2006,"16513106","Antitumour activity of [1,2-di(cyclopentadienyl)-1,2-di(p-N,N-dimethylaminophenyl)-ethanediyl] titanium dichloride in xenografted Ehrlich's ascites tumour.","16513106",136]
["(1,2-diamino-4-nitrobenzene)dichloroplatinum(II)","(1,2-diamino-4-nitrobenzene)dichloroplatinum(II)","C052444","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1988,"3356002","Effect of hypoxia and acidosis on the cytotoxicity of four platinum complexes at normal and hyperthermic temperatures.","3356002",136]
["(1,2-diaminocyclohexane)(5,6-dimethyl-1,10-phenanthroline)platinum(II)","(1,2-diaminocyclohexane)(5,6-dimethyl-1,10-phenanthroline)platinum(II)","C539772","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2013,"23784536","The effects of 56MESS on mitochondrial and cytoskeletal proteins and the cell cycle in MDCK cells.","23784536",136]
["(1,3,5-triaminocyclohexane)copper(II)","(1,3,5-triaminocyclohexane)copper(II)","C472375","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2002,"12203021","Copper(II)- cis, cis-1,3,5-triaminocyclohexane complex-promoted hydrolysis of dipeptides: kinetic, speciation and structural studies.","12203021",136]
["(1,4,7)triazecan-9-ol","(1,4,7)triazecan-9-ol","C492882","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2004,"15050623","Nickel(II) and cobalt(II) complexes of hydroxyl-substituted triazamacrocyclic ligand as potential antitumor agents.","15050623",136]
["(1,4,7)triazecan-9-ol","(1,4,7)triazecan-9-ol","C492882","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2004,"15050623","Nickel(II) and cobalt(II) complexes of hydroxyl-substituted triazamacrocyclic ligand as potential antitumor agents.","15050623",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C195,B195)","v":"(1,4,7,10-tetrakis((N-(1H-imidazol-2-yl)carbamoyl)methyl)-1,4,7,10-tetraazacyclododecane)thulium(III)"},"(1,4,7,10-tetrakis((N-(1H-imidazol-2-yl)carbamoyl)methyl)-1,4,7,10-tetraazacyclododecane)thulium(III)","C533989","1_MIE",867,1,"Intracellular pH","Decrease",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J195,K195)","v":"Hydrogen-Ion Concentration"},"D006863","Hydrogen-Ion Concentration",2,2,2008,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q195,Q195)","v":"18729087"},"The thulium complex of 1,4,7,10-tetrakis{[N-(1H-imidazol-2-yl)carbamoyl]methyl}-1,4,7,10-tetraazacyclododecane (dotami) as a ParaCEST contrast agent.","18729087",136]
["(1,4,7-triazacyclodecane)platinum(II)","(1,4,7-triazacyclodecane)platinum(II)","C543510","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2008,"18717336","[Synthesis and antitumor activities of triazacyclodecane and its platinum (II) complex].","18717336",136]
["(1,8-dimethyl-1,3,6,8,10,13-hexaazacyclotetradecane)nickel(II)","(1,8-dimethyl-1,3,6,8,10,13-hexaazacyclotetradecane)nickel(II)","C573701","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"22341490","Degradation of Malachite green by Potassium persulphate, its enhancement by 1,8-dimethyl-1,3,6,8,10,13-hexaazacyclotetradecane nickel(II) perchlorate complex, and removal of antibacterial activity.","22341490",136]
["(10)-dehydrogingerdione","(10)-dehydrogingerdione","C561631","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22489648","1-Dehydro-[10]-gingerdione from ginger inhibits IKKβ activity for NF-κB activation and suppresses NF-κB-regulated expression of inflammatory genes.","22489648",136]
["(10)-dehydrogingerdione","(10)-dehydrogingerdione","C561631","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2013,"24267247","10-Dehydrogingerdione raises HDL-cholesterol through a CETP inhibition and wards off oxidation and inflammation in dyslipidemic rabbits.","24267247",136]
["(10)-gingerdiol","(10)-gingerdiol","C000589423","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28112417","[10]-Gingerol Reverts Malignant Phenotype of Breast Cancer Cells in 3D Culture.","28112417",136]
["(10)-shogaol","(10)-shogaol","C585130","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22408422","10-Shogaol, an antioxidant from Zingiber officinale for skin cell proliferation and migration enhancer.","22408422",136]
["(10-methyl-9-anthryl)methyl imidothiocarbamate","(10-methyl-9-anthryl)methyl imidothiocarbamate","C568282","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"25113507","XI-011 enhances cisplatin-induced apoptosis by functional restoration of p53 in head and neck cancer.","25113507",136]
["(10-methyl-9-anthryl)methyl imidothiocarbamate","(10-methyl-9-anthryl)methyl imidothiocarbamate","C568282","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"25113507","XI-011 enhances cisplatin-induced apoptosis by functional restoration of p53 in head and neck cancer.","25113507",136]
["(11aS)-8-hydroxy-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo(2,1-c)(1,4)benzodiazepin-5-one","(11aS)-8-hydroxy-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo(2,1-c)(1,4)benzodiazepin-5-one","C474072","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2007,"17530784","DC-81-Indole conjugate agent induces mitochondria mediated apoptosis in human melanoma A375 cells.","17530784",136]
["(11aS)-8-hydroxy-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo(2,1-c)(1,4)benzodiazepin-5-one","(11aS)-8-hydroxy-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo(2,1-c)(1,4)benzodiazepin-5-one","C474072","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2009,"19131253","Synthesis and antitumor activity of novel enediyne-linked pyrrolo[2,1-c][1,4]benzodiazepine hybrids.","19131253",136]
["(11aS)-8-hydroxy-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo(2,1-c)(1,4)benzodiazepin-5-one","(11aS)-8-hydroxy-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo(2,1-c)(1,4)benzodiazepin-5-one","C474072","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"21708181","A DC-81-indole conjugate agent suppresses melanoma A375 cell migration partially via interrupting VEGF production and stromal cell-derived factor-1α-mediated signaling.","21708181",136]
["(11aS)-8-hydroxy-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo(2,1-c)(1,4)benzodiazepin-5-one","(11aS)-8-hydroxy-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo(2,1-c)(1,4)benzodiazepin-5-one","C474072","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2004,"15109675","The effect of C2-fluoro group on the biological activity of DC-81 and its dimers.","15109675",136]
["(11aS)-8-hydroxy-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo(2,1-c)(1,4)benzodiazepin-5-one","(11aS)-8-hydroxy-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo(2,1-c)(1,4)benzodiazepin-5-one","C474072","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,3,2007,"17530784","DC-81-Indole conjugate agent induces mitochondria mediated apoptosis in human melanoma A375 cells.","17530784",136]
["(13-(2-(butylamino)-2-oxoacetamido)tridec-8(Z)-enoic acid)","(13-(2-(butylamino)-2-oxoacetamido)tridec-8(Z)-enoic acid)","C558112","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"21039415","Cardioprotective effect of a dual acting epoxyeicosatrienoic acid analogue towards ischaemia reperfusion injury.","21039415",136]
["(13-(3-propylureido)tridec-8-enoic acid)","(13-(3-propylureido)tridec-8-enoic acid)","C558111","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"21039415","Cardioprotective effect of a dual acting epoxyeicosatrienoic acid analogue towards ischaemia reperfusion injury.","21039415",136]
["(13aS)-deoxytylophorinine","(13aS)-deoxytylophorinine","C569808","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22276180","Synthesis, biological evaluation and mechanism studies of deoxytylophorinine and its derivatives as potential anticancer agents.","22276180",136]
["(14E,18E,22E,26E)-methyl nonacosa-14,18,22,26 tetraenoate","(14E,18E,22E,26E)-methyl nonacosa-14,18,22,26 tetraenoate","C000602013","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27669220","A Novel Tetraenoic Fatty Acid Isolated from Amaranthus spinosus Inhibits Proliferation and Induces Apoptosis of Human Liver Cancer Cells.","27669220",136]
["(14E,18E,22E,26E)-methyl nonacosa-14,18,22,26 tetraenoate","(14E,18E,22E,26E)-methyl nonacosa-14,18,22,26 tetraenoate","C000602013","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27669220","A Novel Tetraenoic Fatty Acid Isolated from Amaranthus spinosus Inhibits Proliferation and Induces Apoptosis of Human Liver Cancer Cells.","27669220",136]
["(1-6)-alpha-glucomannan","(1-6)-alpha-glucomannan","C022901","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2008,"18067882","Photoprotective effects of glucomannan isolated from Candida utilis.","18067882",136]
["(1-6)-alpha-glucomannan","(1-6)-alpha-glucomannan","C022901","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"25245263","Targeted depletion of tumour-associated macrophages by an alendronate-glucomannan conjugate for cancer immunotherapy.","25245263",136]
["(1-6)-alpha-glucomannan","(1-6)-alpha-glucomannan","C022901","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2005,"16269167","Immunohistochemical study of proliferating cell nuclear antigen (PCNA) in duckling liver fed with aflatoxin B1 and esterified glucomannan.","16269167",136]
["(1-6)-alpha-glucomannan","(1-6)-alpha-glucomannan","C022901","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2009,"19399729","Konjac glucomannan-based hydrogel with hyaluronic acid as a candidate for a novel scaffold for chondrocyte culture.","19399729",136]
["(1-6)-alpha-glucomannan","(1-6)-alpha-glucomannan","C022901","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25498700","Alkali-treated konjac glucomannan film as a novel wound dressing.","25498700",136]
["(1-6)-alpha-glucomannan","(1-6)-alpha-glucomannan","C022901","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2002,"12749587","Aflatoxin binders I: in vitro binding assay for aflatoxin B1 by several potential sequestering agents.","12749587",136]
["(1-6)-alpha-glucomannan","(1-6)-alpha-glucomannan","C022901","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2005,"15529331","Novel polyelectrolyte carboxymethyl konjac glucomannan-chitosan nanoparticles for drug delivery. II. Release of albumin in vitro.","15529331",136]
["(1-6)-alpha-glucomannan","(1-6)-alpha-glucomannan","C022901","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2005,"15739184","Novel polyelectrolyte carboxymethyl konjac glucomannan-chitosan nanoparticles for drug delivery. I. Physicochemical characterization of the carboxymethyl konjac glucomannan-chitosan nanoparticles.","15739184",136]
["(1-6)-alpha-glucomannan","(1-6)-alpha-glucomannan","C022901","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"16905245","Adsorption of heavy metal ions from aqueous solution by crosslinked carboxymethyl konjac glucomannan.","16905245",136]
["(1-6)-alpha-glucomannan","(1-6)-alpha-glucomannan","C022901","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2006,"17027233","Konjac acts as a natural laxative by increasing stool bulk and improving colonic ecology in healthy adults.","17027233",136]
["(1-6)-alpha-glucomannan","(1-6)-alpha-glucomannan","C022901","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"18257258","[Study on in vitro colon-specific enzymatic degradation performance of carboxymethyl konjac glucomannan].","18257258",136]
["(1-6)-alpha-glucomannan","(1-6)-alpha-glucomannan","C022901","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"18309662","[Studies on drug release from aminophylline konjac glucomannan matrix tablet].","18309662",136]
["(1-6)-alpha-glucomannan","(1-6)-alpha-glucomannan","C022901","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2008,"18460488","Supplementation of konjac glucomannan into a low-fiber Chinese diet promoted bowel movement and improved colonic ecology in constipated adults: a placebo-controlled, diet-controlled trial.","18460488",136]
["(1-6)-alpha-glucomannan","(1-6)-alpha-glucomannan","C022901","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2008,"18725277","Semi-permeable nanocapsules of konjac glucomannan-chitosan for enzyme immobilization.","18725277",136]
["(1-6)-alpha-glucomannan","(1-6)-alpha-glucomannan","C022901","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2009,"19604636","Removal of copper and lead from aqueous solution by carboxylic acid functionalized deacetylated konjac glucomannan.","19604636",136]
["(1-6)-alpha-glucomannan","(1-6)-alpha-glucomannan","C022901","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2009,"19650505","[Crosslinked carboxymethyl konjac glucomannan microcolumn preconcentration of trace lead, cadmium and copper in water samples and determination by graphite furnace atomic absorption spectrometry].","19650505",136]
["(1-6)-alpha-glucomannan","(1-6)-alpha-glucomannan","C022901","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2010,"20193979","Adsorption of tannin from aqueous solution by deacetylated konjac glucomannan.","20193979",136]
["(1-6)-alpha-glucomannan","(1-6)-alpha-glucomannan","C022901","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2010,"20647679","Characterization of the endoglucanase and glucomannanase activities of a glycoside hydrolase family 45 protein from Penicillium decumbens 114-2.","20647679",136]
["(1-6)-alpha-glucomannan","(1-6)-alpha-glucomannan","C022901","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2011,"22112413","Purification and characterization of a β-1,3-glucomannanase expressed in Pichia pastoris.","22112413",136]
["(1-6)-alpha-glucomannan","(1-6)-alpha-glucomannan","C022901","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2011,"22195909","In vitro evaluation of Konjac glucomannan as novel excipients for floating systems.","22195909",136]
["(1-6)-alpha-glucomannan","(1-6)-alpha-glucomannan","C022901","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2011,"22195928","Controlled acid hydrolysis and acetylation of glucomannans as drug carriers with designed pharmacokinetic behaviors.","22195928",136]
["(1-6)-alpha-glucomannan","(1-6)-alpha-glucomannan","C022901","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2013,"22820522","Production of polysaccharide from Agaricus subrufescens Peck on solid-state fermentation.","22820522",136]
["(1-6)-alpha-glucomannan","(1-6)-alpha-glucomannan","C022901","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"22822444","The effect of three gums on the retrogradation of indica rice starch.","22822444",136]
["(1-6)-alpha-glucomannan","(1-6)-alpha-glucomannan","C022901","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2013,"23465904","Optimization of hydrolysis conditions for the production of glucomanno-oligosaccharides from konjac using β-mannanase by response surface methodology.","23465904",136]
["(1-6)-alpha-glucomannan","(1-6)-alpha-glucomannan","C022901","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2013,"23911486","KGM and PMAA based pH-sensitive interpenetrating polymer network hydrogel for controlled drug release.","23911486",136]
["(1-6)-alpha-glucomannan","(1-6)-alpha-glucomannan","C022901","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2013,"23987407","The effect of degradation on κ-carrageenan/locust bean gum/konjac glucomannan gels at acidic pH.","23987407",136]
["(1-6)-alpha-glucomannan","(1-6)-alpha-glucomannan","C022901","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"24096158","Controlled release of anticancer drug using graphene oxide as a drug-binding effector in konjac glucomannan/sodium alginate hydrogels.","24096158",136]
["(1-6)-alpha-glucomannan","(1-6)-alpha-glucomannan","C022901","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"24274506","Synergistic degradation of konjac glucomannan by alkaline and thermal method.","24274506",136]
["(1-6)-alpha-glucomannan","(1-6)-alpha-glucomannan","C022901","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2015,"25466024","A thermophilic β-mannanase from Neosartorya fischeri P1 with broad pH stability and significant hydrolysis ability of various mannan polymers.","25466024",136]
["(1-6)-alpha-glucomannan","(1-6)-alpha-glucomannan","C022901","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2015,"25498602","Preparation and characterization of a novel pH-response dietary fiber: chitosan-coated konjac glucomannan.","25498602",136]
["(1-6)-alpha-glucomannan","(1-6)-alpha-glucomannan","C022901","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2015,"26428126","Effects of pH and temperature on colloidal properties and molecular characteristics of Konjac glucomannan.","26428126",136]
["(1-6)-alpha-glucomannan","(1-6)-alpha-glucomannan","C022901","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2016,"26814828","Development of Mag-FMBO in clay-reinforced KGM aerogels for arsenite removal.","26814828",136]
["(1-6)-alpha-glucomannan","(1-6)-alpha-glucomannan","C022901","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2016,"26826287","Removal of copper(II) using deacetylated konjac glucomannan conjugated soy protein isolate.","26826287",136]
["(1-6)-alpha-glucomannan","(1-6)-alpha-glucomannan","C022901","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2016,"27083814","Synthesis and evaluation of a novel cationic konjac glucomannan-based flocculant.","27083814",136]
["(1-6)-alpha-glucomannan","(1-6)-alpha-glucomannan","C022901","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2017,"27835835","Effect of natural antioxidants in Spanish salchichón elaborated with encapsulated n-3 long chain fatty acids in konjac glucomannan matrix.","27835835",136]
["(1-6)-alpha-glucomannan","(1-6)-alpha-glucomannan","C022901","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2017,"28578975","pH-Sensitive drug delivery system based on hydrophobic modified konjac glucomannan.","28578975",136]
["(1-6)-alpha-glucomannan","(1-6)-alpha-glucomannan","C022901","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1997,"9362121","Purification and characterization of konjac glucomannan degrading enzyme from anaerobic human intestinal bacterium, Clostridium butyricum-Clostridium beijerinckii group.","9362121",136]
["(16-mercapto)hexadecanoic acid (2-chlorophenyl)diphenylmethyl ester","(16-mercapto)hexadecanoic acid (2-chlorophenyl)diphenylmethyl ester","C470761","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2003,"12532011","A reversibly switching surface.","12532011",136]
["(18)F-ICMT11","(18)F-ICMT11","C571272","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2011,"22030029","Improved radiosynthesis of the apoptosis marker 18F-ICMT11 including biological evaluation.","22030029",136]
["(18)F-ICMT11","(18)F-ICMT11","C571272","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2012,"22226480","Imaging apoptosis with positron emission tomography: 'bench to bedside' development of the caspase-3/7 specific radiotracer [(18)F]ICMT-11.","22226480",136]
["(18)F-ICMT11","(18)F-ICMT11","C571272","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2013,"23949910","18F-ICMT-11, a caspase-3-specific PET tracer for apoptosis: biodistribution and radiation dosimetry.","23949910",136]
["(18)F-ICMT11","(18)F-ICMT11","C571272","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2014,"24618809","Preclinical assessment of carboplatin treatment efficacy in lung cancer by 18F-ICMT-11-positron emission tomography.","24618809",136]
["(19Z)-halichondramide","(19Z)-halichondramide","C495172","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23147639","Anti-proliferative effect of (19Z)-halichondramide, a novel marine macrolide isolated from the sponge Chondrosia corticata, is associated with G2/M cell cycle arrest and suppression of mTOR signaling in human lung cancer cells.","23147639",136]
["(1alpha,2alpha,8beta,9beta)-1,8-bis(acetyloxy)-2,9-bis(benzoyloxy)-14-hydroxy-beta-dihydroagarofuran","(1alpha,2alpha,8beta,9beta)-1,8-bis(acetyloxy)-2,9-bis(benzoyloxy)-14-hydroxy-beta-dihydroagarofuran","C587585","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23810286","Cytotoxic constituents from Celastrus paniculatus induce apoptosis and autophagy in breast cancer cells.","23810286",136]
["(1alpha,2alpha,8beta,9beta)-1,8-bis(acetyloxy)-2,9-bis(benzoyloxy)-14-hydroxy-beta-dihydroagarofuran","(1alpha,2alpha,8beta,9beta)-1,8-bis(acetyloxy)-2,9-bis(benzoyloxy)-14-hydroxy-beta-dihydroagarofuran","C587585","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23810286","Cytotoxic constituents from Celastrus paniculatus induce apoptosis and autophagy in breast cancer cells.","23810286",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C259,B259)","v":"(1-chloroethenyl)oxirane"},"(1-chloroethenyl)oxirane","C439367","1_MIE",867,1,"Intracellular pH","Decrease",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J259,K259)","v":"Hydrogen-Ion Concentration"},"D006863","Hydrogen-Ion Concentration",2,2,2010,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q259,Q259)","v":"20030381"},"DNA interstrand cross-linking activity of (1-Chloroethenyl)oxirane, a metabolite of beta-chloroprene.","20030381",136]
["(1E)-1-((pyridin-2-yl)methyleneamino)-3-(3-(pyridin-2-yl)imidazo(1,5-a)pyridin-2(3H)-yl)propan-2-ol","(1E)-1-((pyridin-2-yl)methyleneamino)-3-(3-(pyridin-2-yl)imidazo(1,5-a)pyridin-2(3H)-yl)propan-2-ol","C560104","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2011,"21431236","Impact of metal binding on the antitumor activity and cellular imaging of a metal chelator cationic imidazopyridine derivative.","21431236",136]
["(1E,4E)-1,5-bis(2-methoxyphenyl)penta-1,4-dien-3-one","(1E,4E)-1,5-bis(2-methoxyphenyl)penta-1,4-dien-3-one","C571782","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22159410","A novel mono-carbonyl analogue of curcumin induces apoptosis in ovarian             carcinoma cells via endoplasmic reticulum stress and reactive oxygen species production.","22159410",136]
["(1-ferrocenyl-4,4,4-trifluoro-1,3-butanedionat-k2O,O')rhodium(I)","(1-ferrocenyl-4,4,4-trifluoro-1,3-butanedionat-k2O,O')rhodium(I)","C487804","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2004,"15161024","Cytotoxicity and cell death pathways invoked by two new rhodium-ferrocene complexes in benign and malignant prostatic cell lines.","15161024",136]
["(1-methylene-(4-nitrophenol)-1,4,7,10-tetraazacyclododecane-4,7,10-triacetamide)gadolinium(III)","(1-methylene-(4-nitrophenol)-1,4,7,10-tetraazacyclododecane-4,7,10-triacetamide)gadolinium(III)","C492702","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2004,"15281814","Synthesis, relaxometric and photophysical properties of a new pH-responsive MRI contrast agent: the effect of other ligating groups on dissociation of a p-nitrophenolic pendant arm.","15281814",136]
["(1-methylene-(4-nitrophenol)-1,4,7,10-tetraazacyclododecane-4,7,10-triacetate)gadolinium(III)","(1-methylene-(4-nitrophenol)-1,4,7,10-tetraazacyclododecane-4,7,10-triacetate)gadolinium(III)","C492701","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2004,"15281814","Synthesis, relaxometric and photophysical properties of a new pH-responsive MRI contrast agent: the effect of other ligating groups on dissociation of a p-nitrophenolic pendant arm.","15281814",136]
["(1-O-octadecyl-2-O-(2'-deoxy-2'-aminoglucopyranosyl)glycerol(3))phosphorylcholine","(1-O-octadecyl-2-O-(2'-deoxy-2'-aminoglucopyranosyl)glycerol(3))phosphorylcholine","C505983","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2005,"16220990","Glucosamine-glycerophospholipids that activate cell-matrix adhesion and migration.","16220990",136]
["(1-O-octadecyl-2-O-(2'-deoxy-2'-dimethylmaleimidoglucopyranosyl)glycerol(3))phosphorylcholine","(1-O-octadecyl-2-O-(2'-deoxy-2'-dimethylmaleimidoglucopyranosyl)glycerol(3))phosphorylcholine","C505984","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2005,"16220990","Glucosamine-glycerophospholipids that activate cell-matrix adhesion and migration.","16220990",136]
["(1-oxyl-2,2,5,5-tetramethylpyrroline-3-methyl)methanethiosulfonate","(1-oxyl-2,2,5,5-tetramethylpyrroline-3-methyl)methanethiosulfonate","C034248","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1982,"6280514","A novel reversible thiol-specific spin label: papain active site labeling and inhibition.","6280514",136]
["(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester","(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester","C021279","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1991,"1896028","Binding of the cocaine analog 2 beta-[3H] carboxymethoxy-3 beta-(4-fluorophenyl)tropane to the serotonin transporter.","1896028",136]
["(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester","(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester","C021279","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1996,"8819521","Modeling of the pH dependence of the binding of WIN 35,428 to the dopamine transporter in rat striatal membranes: is the bioactive form positively charged or neutral?","8819521",136]
["(1R,2S)-(-)-N-dodecyl-N-methylephedrinium bromide","(1R,2S)-(-)-N-dodecyl-N-methylephedrinium bromide","C514924","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2006,"16949598","Tunable sustained release properties of \"onion-like\" phospholipids multilamellar vesicles.","16949598",136]
["(1r,4r)-4-amino-N-(3,5-bis(4-carbamimidoylphenoxy)phenyl)cyclohexanecarboxamide","(1r,4r)-4-amino-N-(3,5-bis(4-carbamimidoylphenoxy)phenyl)cyclohexanecarboxamide","C000600996","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24794746","Structure-guided discovery of 1,3,5 tri-substituted benzenes as potent and selective matriptase inhibitors exhibiting in vivo antitumor efficacy.","24794746",136]
["(1RS,5SR,6RS)-5-hydroxybicyclo(4.3.0)non-2-ene-2-carbaldehyde","(1RS,5SR,6RS)-5-hydroxybicyclo(4.3.0)non-2-ene-2-carbaldehyde","C543382","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"19194839","Bicyclononane aldehydes and antiproliferative constituents from Amomum tsao-ko.","19194839",136]
["(1S*,3R*,5R*)-3-methyl-2-oxa-bicyclo(3.3.1)nonan-7-one","(1S*,3R*,5R*)-3-methyl-2-oxa-bicyclo(3.3.1)nonan-7-one","C579827","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23387901","Tubulin inhibitors from an endophytic fungus isolated from Cedrus deodara.","23387901",136]
["(1S,2E,4R,6R,7E,11E)-2,7,11-cembratriene-4,6-diol","(1S,2E,4R,6R,7E,11E)-2,7,11-cembratriene-4,6-diol","C569865","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27681240","(1S,2E,4S,7E,11E)-2,7,11-Cembratriene-4,6-diol semisynthetic analogs as novel c-Met inhibitors for the control of c-Met-dependent breast malignancies.","27681240",136]
["(1S,2S)-2-(2-(N-((3-benzimidazol-2-yl)propyl)-N-methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride","(1S,2S)-2-(2-(N-((3-benzimidazol-2-yl)propyl)-N-methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride","C484287","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25989794","T-type calcium channel antagonists, mibefradil and NNC-55-0396 inhibit cell proliferation and induce cell apoptosis in leukemia cell lines.","25989794",136]
["(1S,2S)-2-(2-(N-((3-benzimidazol-2-yl)propyl)-N-methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride","(1S,2S)-2-(2-(N-((3-benzimidazol-2-yl)propyl)-N-methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride","C484287","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2008,"18455293","Selective blockade of T-type Ca2+ channels suppresses human breast cancer cell proliferation.","18455293",136]
["(1S,2S)-2-(2-(N-((3-benzimidazol-2-yl)propyl)-N-methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride","(1S,2S)-2-(2-(N-((3-benzimidazol-2-yl)propyl)-N-methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride","C484287","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21438841","Blockade of T-type Ca(2+) channels inhibits human ovarian cancer cell proliferation.","21438841",136]
["(1S,2S)-2-(2-(N-((3-benzimidazol-2-yl)propyl)-N-methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride","(1S,2S)-2-(2-(N-((3-benzimidazol-2-yl)propyl)-N-methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride","C484287","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25989794","T-type calcium channel antagonists, mibefradil and NNC-55-0396 inhibit cell proliferation and induce cell apoptosis in leukemia cell lines.","25989794",136]
["(1S,2S)-2-(2-(N-((3-benzimidazol-2-yl)propyl)-N-methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride","(1S,2S)-2-(2-(N-((3-benzimidazol-2-yl)propyl)-N-methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride","C484287","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2015,"25471482","NNC 55-0396, a T-type Ca2+ channel inhibitor, inhibits angiogenesis via suppression of hypoxia-inducible factor-1α signal transduction.","25471482",136]
["(1S,2S,3E,7E,11E)-3,7,11,15-cembratetraen-17,2-olide","(1S,2S,3E,7E,11E)-3,7,11,15-cembratetraen-17,2-olide","C576714","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22791152","(1S,2S,3E,7E,11E)-3,7,11,15-Cembratetraen-17,2-olide, a cembrenolide diterpene from soft coral Lobophytum sp., inhibits growth and induces apoptosis in human colon cancer cells through reactive oxygen species generation.","22791152",136]
["(1S,2S,3E,7E,11E)-3,7,11,15-cembratetraen-17,2-olide","(1S,2S,3E,7E,11E)-3,7,11,15-cembratetraen-17,2-olide","C576714","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25786063","The anticancer effect of (1S,2S,3E,7E,11E)-3,7,11, 15-cembratetraen-17,2-olide(LS-1) through the activation of TGF-β signaling in SNU-C5/5-FU, fluorouracil-resistant human colon cancer cells.","25786063",136]
["(1S,2S,3E,7E,11E)-3,7,11,15-cembratetraen-17,2-olide","(1S,2S,3E,7E,11E)-3,7,11,15-cembratetraen-17,2-olide","C576714","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22791152","(1S,2S,3E,7E,11E)-3,7,11,15-Cembratetraen-17,2-olide, a cembrenolide diterpene from soft coral Lobophytum sp., inhibits growth and induces apoptosis in human colon cancer cells through reactive oxygen species generation.","22791152",136]
["(1-vinyl-2-pyrrolidone)-(maleic anhydride) copolymer","(1-vinyl-2-pyrrolidone)-(maleic anhydride) copolymer","C102419","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1996,"8842365","Coated reactive carriers based on copolymers of 1-vinyl-2-pyrrolidone and maleic anhydride for immobilization of enzymes.","8842365",136]
["(2 S)-5,7,4'-trihydroxy-2'-methoxy-8,5'- di(3-methyl-2-butenyl)-6-methyflavanone","(2 S)-5,7,4'-trihydroxy-2'-methoxy-8,5'- di(3-methyl-2-butenyl)-6-methyflavanone","C555980","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20309799","Two prenylated and C-methylated flavonoids from Tripterygium wilfordii.","20309799",136]
["(2'-((cyclopropanecarbonylethylamino)methyl)-6-methoxy-4'-trifluoromethyl-biphenyl-3-yl)acetic acid","(2'-((cyclopropanecarbonylethylamino)methyl)-6-methoxy-4'-trifluoromethyl-biphenyl-3-yl)acetic acid","C548542","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Metaplasia","D008679","Metaplasia",2,2,2010,"20447387","Therapeutic efficacy of AM156, a novel prostanoid DP2 receptor antagonist, in murine models of allergic rhinitis and house dust mite-induced pulmonary inflammation.","20447387",136]
["(2-(1-(3-methoxycarbonylmethyl-1H-indol-2-yl)-1-methylethyl)-1H-indol-3-yl)acetic acid methyl ester","(2-(1-(3-methoxycarbonylmethyl-1H-indol-2-yl)-1-methylethyl)-1H-indol-3-yl)acetic acid methyl ester","C559930","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25661348","{2-[1-(3-Methoxycarbonylmethyl-1H-indol-2-yl)-1-methyl-ethyl]-1H-indol-3-yl}-acetic acid methyl ester (MIAM) inhibited human hepatocellular carcinoma growth through upregulation of Sirtuin-3 (SIRT3).","25661348",136]
["(2-(1-(3-methoxycarbonylmethyl-1H-indol-2-yl)-1-methylethyl)-1H-indol-3-yl)acetic acid methyl ester","(2-(1-(3-methoxycarbonylmethyl-1H-indol-2-yl)-1-methylethyl)-1H-indol-3-yl)acetic acid methyl ester","C559930","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25961022","{2-[1-(3-Methoxycarbonylmethyl-1H-indol-2-yl)-1-methyl-ethyl]-1H-indol-3-yl}-acetic Acid Methyl Ester Inhibited Hepatocellular Carcinoma Growth in Bel-7402 Cells and Its Resistant Variants by Activation of NOX4 and SIRT3.","25961022",136]
["(2-(1-(3-methoxycarbonylmethyl-1H-indol-2-yl)-1-methylethyl)-1H-indol-3-yl)acetic acid methyl ester","(2-(1-(3-methoxycarbonylmethyl-1H-indol-2-yl)-1-methylethyl)-1H-indol-3-yl)acetic acid methyl ester","C559930","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21116565","{2-[1-(3-Methoxycarbonylmethyl-1H-indol-2-yl)-1-methyl-ethyl]-1H-indol-3-yl}-acetic acid methyl ester (MIAM): its anti-cancer efficacy and intercalation mechanism identified via multi-model systems.","21116565",136]
["(2-(1-(3-methoxycarbonylmethyl-1H-indol-2-yl)-1-methylethyl)-1H-indol-3-yl)acetic acid methyl ester","(2-(1-(3-methoxycarbonylmethyl-1H-indol-2-yl)-1-methylethyl)-1H-indol-3-yl)acetic acid methyl ester","C559930","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25661348","{2-[1-(3-Methoxycarbonylmethyl-1H-indol-2-yl)-1-methyl-ethyl]-1H-indol-3-yl}-acetic acid methyl ester (MIAM) inhibited human hepatocellular carcinoma growth through upregulation of Sirtuin-3 (SIRT3).","25661348",136]
["(2-(1-(3-methoxycarbonylmethyl-1H-indol-2-yl)-1-methylethyl)-1H-indol-3-yl)acetic acid methyl ester","(2-(1-(3-methoxycarbonylmethyl-1H-indol-2-yl)-1-methylethyl)-1H-indol-3-yl)acetic acid methyl ester","C559930","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25961022","{2-[1-(3-Methoxycarbonylmethyl-1H-indol-2-yl)-1-methyl-ethyl]-1H-indol-3-yl}-acetic Acid Methyl Ester Inhibited Hepatocellular Carcinoma Growth in Bel-7402 Cells and Its Resistant Variants by Activation of NOX4 and SIRT3.","25961022",136]
["(2-(1-diethylaminoacetoxy)pentyl)benzoic acid (2-methoxy-4-(2-(4-nitrooxybutoxycarbonyl)vinyl))phenyl ester","(2-(1-diethylaminoacetoxy)pentyl)benzoic acid (2-methoxy-4-(2-(4-nitrooxybutoxycarbonyl)vinyl))phenyl ester","C554089","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24277159","(S)-ZJM-289 preconditioning induces a late phase protection against nervous injury induced by transient cerebral ischemia and oxygen-glucose deprivation.","24277159",136]
["(2-(2-(4-chlorobenzyloxy)phenoxy)ethyl)-(2-(2,6-dimethoxyphenoxy)ethyl)amine","(2-(2-(4-chlorobenzyloxy)phenoxy)ethyl)-(2-(2,6-dimethoxyphenoxy)ethyl)amine","C507721","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2005,"16302814","Structure-activity relationships in 1,4-benzodioxan-related compounds. 8.(1) {2-[2-(4-chlorobenzyloxy)phenoxy]ethyl}-[2-(2,6-dimethoxyphenoxy)ethyl]amine (clopenphendioxan) as a tool to highlight the involvement of alpha1D- and alpha1B-adrenoreceptor subtypes in the regulation of human PC-3 prostate cancer cell apoptosis and proliferation.","16302814",136]
["(2-(2-(4-chlorobenzyloxy)phenoxy)ethyl)-(2-(2,6-dimethoxyphenoxy)ethyl)amine","(2-(2-(4-chlorobenzyloxy)phenoxy)ethyl)-(2-(2,6-dimethoxyphenoxy)ethyl)amine","C507721","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2005,"16302814","Structure-activity relationships in 1,4-benzodioxan-related compounds. 8.(1) {2-[2-(4-chlorobenzyloxy)phenoxy]ethyl}-[2-(2,6-dimethoxyphenoxy)ethyl]amine (clopenphendioxan) as a tool to highlight the involvement of alpha1D- and alpha1B-adrenoreceptor subtypes in the regulation of human PC-3 prostate cancer cell apoptosis and proliferation.","16302814",136]
["(2-(2',3'-dihydrobenzo(1,4)dioxin-6'-yl)-2-hydroxy-1-pyrrolidin-1-ylmethylethyl)nonanoic acid amide","(2-(2',3'-dihydrobenzo(1,4)dioxin-6'-yl)-2-hydroxy-1-pyrrolidin-1-ylmethylethyl)nonanoic acid amide","C520404","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"21186402","The chemosensitizing activity of inhibitors of glucosylceramide synthase is mediated primarily through modulation of P-gp function.","21186402",136]
["(2-(2',3'-dihydrobenzo(1,4)dioxin-6'-yl)-2-hydroxy-1-pyrrolidin-1-ylmethylethyl)nonanoic acid amide","(2-(2',3'-dihydrobenzo(1,4)dioxin-6'-yl)-2-hydroxy-1-pyrrolidin-1-ylmethylethyl)nonanoic acid amide","C520404","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21186402","The chemosensitizing activity of inhibitors of glucosylceramide synthase is mediated primarily through modulation of P-gp function.","21186402",136]
["(2-(2,5-dimethoxyphenylthio)-6-methoxybenzylideneamino)guanidine","(2-(2,5-dimethoxyphenylthio)-6-methoxybenzylideneamino)guanidine","C541073","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2009,"19282188","Discovery and structure-activity relationships of (2-(arylthio)benzylideneamino)guanidines as a novel series of potent apoptosis inducers.","19282188",136]
["(2-(2,6-dichloro-phenylamino)-phenyl)-acetic acid","(2-(2,6-dichloro-phenylamino)-phenyl)-acetic acid","C546555","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2009,"19879184","Spectrophotometric determination of [2-(2,6-dichloro-phenylamino)-phenyl]-acetic acid in pure form and in pharmaceuticals.","19879184",136]
["(2-(4-methoxyphenyl)-4-quinolinyl)(2-piperidinyl)methanol","(2-(4-methoxyphenyl)-4-quinolinyl)(2-piperidinyl)methanol","C546115","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22400811","Synthesis and evaluation of (2-(4-methoxyphenyl)-4-quinolinyl)(2-piperidinyl)methanol (NSC23925) isomers to reverse multidrug resistance in cancer.","22400811",136]
["(2-(4-methoxyphenyl)-4-quinolinyl)(2-piperidinyl)methanol","(2-(4-methoxyphenyl)-4-quinolinyl)(2-piperidinyl)methanol","C546115","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2015,"25904021","Nsc23925 prevents the development of paclitaxel resistance by inhibiting the introduction of P-glycoprotein and enhancing apoptosis.","25904021",136]
["(2-(4-methoxyphenyl)-4-quinolinyl)(2-piperidinyl)methanol","(2-(4-methoxyphenyl)-4-quinolinyl)(2-piperidinyl)methanol","C546115","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25904021","Nsc23925 prevents the development of paclitaxel resistance by inhibiting the introduction of P-glycoprotein and enhancing apoptosis.","25904021",136]
["(2-(6-aminopurine-9-yl)-1-hydroxy-phosphine acyl ethyl)phosphonic acid","(2-(6-aminopurine-9-yl)-1-hydroxy-phosphine acyl ethyl)phosphonic acid","C000588614","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"24241351","A new bisphosphonate derivative, CP, induces gastric cancer cell apoptosis via activation of the ERK1/2 signaling pathway.","24241351",136]
["(2,2'-6',2'')-terpyridine","(2,2'-6',2'')-terpyridine","C517923","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23942760","Synthesis, spectroscopic and biological studies of a fluorescent Pt(II) (terpy) based 1,8-naphthalimide conjugate as a DNA targeting agent.","23942760",136]
["(2,2'-6',2'')-terpyridine","(2,2'-6',2'')-terpyridine","C517923","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28884428","In vitro and in vivo anti-proliferative evaluation of bis(4'-(4-tolyl)-2,2':6',2″-terpyridine)copper(II) complex against Ehrlich ascites carcinoma tumors.","28884428",136]
["(2,2'-6',2'')-terpyridine","(2,2'-6',2'')-terpyridine","C517923","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23942760","Synthesis, spectroscopic and biological studies of a fluorescent Pt(II) (terpy) based 1,8-naphthalimide conjugate as a DNA targeting agent.","23942760",136]
["(2,2'-6',2'')-terpyridine","(2,2'-6',2'')-terpyridine","C517923","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2015,"26121058","Spectroscopic analysis and in vitro imaging applications of a pH responsive AIE sensor with a two-input inhibit function.","26121058",136]
["(2,2'-bipyridyl)(pentamethylcyclopentadienyl)rhodium","(2,2'-bipyridyl)(pentamethylcyclopentadienyl)rhodium","C476958","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2003,"12837091","Stereospecific biocatalytic epoxidation: the first example of direct regeneration of a FAD-dependent monooxygenase for catalysis.","12837091",136]
["(2,3,5,6,8,9,11,12-octahydro-N-(3-(1,4,7,10-tetraazacyclododec-1-yl)propyl)-1,4,7,10,13-benzopentaoxacyclopentadecin-15-amine)copper(II)","(2,3,5,6,8,9,11,12-octahydro-N-(3-(1,4,7,10-tetraazacyclododec-1-yl)propyl)-1,4,7,10,13-benzopentaoxacyclopentadecin-15-amine)copper(II)","C524279","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"17886837","Synthesis and DNA-cleavage properties of metal complexes of 1,4,7,10-tetraazacyclododecane (cyclen) functionalized with a pendant benzocrown ether.","17886837",136]
["(2,3,5,6-tetrafluoro-4-methoxymethylphenyl)methyl-2,2-dimethyl-3-(1-propenyl)cyclopropanecarboxylate","(2,3,5,6-tetrafluoro-4-methoxymethylphenyl)methyl-2,2-dimethyl-3-(1-propenyl)cyclopropanecarboxylate","C492600","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2009,"19176366","Mode of action analysis for the synthetic pyrethroid metofluthrin-induced rat liver tumors: evidence for hepatic CYP2B induction and hepatocyte proliferation.","19176366",136]
["(2,3,5,6-tetrafluoro-4-methoxymethylphenyl)methyl-2,2-dimethyl-3-(1-propenyl)cyclopropanecarboxylate","(2,3,5,6-tetrafluoro-4-methoxymethylphenyl)methyl-2,2-dimethyl-3-(1-propenyl)cyclopropanecarboxylate","C492600","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"19176366","Mode of action analysis for the synthetic pyrethroid metofluthrin-induced rat liver tumors: evidence for hepatic CYP2B induction and hepatocyte proliferation.","19176366",136]
["(2,3,5,6-tetrafluoro-4-methoxymethylphenyl)methyl-2,2-dimethyl-3-(1-propenyl)cyclopropanecarboxylate","(2,3,5,6-tetrafluoro-4-methoxymethylphenyl)methyl-2,2-dimethyl-3-(1-propenyl)cyclopropanecarboxylate","C492600","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2009,"19176367","Case study: an evaluation of the human relevance of the synthetic pyrethroid metofluthrin-induced liver tumors in rats based on mode of action.","19176367",136]
["(2,3-dihydrobenzo(b)(1,4)dioxin-2-yl)(5-(3-fluorophenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)methanone","(2,3-dihydrobenzo(b)(1,4)dioxin-2-yl)(5-(3-fluorophenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)methanone","C578257","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22985962","Design, modification and 3D QSAR studies of novel 2,3-dihydrobenzo[b][1,4]dioxin-containing 4,5-dihydro-1H-pyrazole derivatives as inhibitors of B-Raf kinase.","22985962",136]
["(2,3-epoxypropyl)benzene","(2,3-epoxypropyl)benzene","C497708","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,1,2010,"20544772","Modification of substrate specificity resulting in an epoxide hydrolase with shifted enantiopreference for (2,3-epoxypropyl)benzene.","20544772",136]
["(2,4-dihydroxy-5-isopropylphenyl)-(5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl)methanone","(2,4-dihydroxy-5-isopropylphenyl)-(5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl)methanone","C552103","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22714264","The HSP90 inhibitor, AT13387, is effective against imatinib-sensitive and -resistant gastrointestinal stromal tumor models.","22714264",136]
["(2,4-dihydroxy-5-isopropylphenyl)-(5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl)methanone","(2,4-dihydroxy-5-isopropylphenyl)-(5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl)methanone","C552103","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"24156782","A novel Hsp90 inhibitor AT13387 induces senescence in EBV-positive nasopharyngeal carcinoma cells and suppresses tumor formation.","24156782",136]
["(2,4-dihydroxy-5-isopropylphenyl)-(5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl)methanone","(2,4-dihydroxy-5-isopropylphenyl)-(5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl)methanone","C552103","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28679777","Efficacy of Onalespib, a Long-Acting Second-Generation HSP90 Inhibitor, as a Single Agent and in Combination with Temozolomide against Malignant Gliomas.","28679777",136]
["(20S*,24R*)-epoxy-9,19-cyclolanstane-3beta,12beta,16beta,25-pentaol-3-O-beta-D-xylopyranoside","(20S*,24R*)-epoxy-9,19-cyclolanstane-3beta,12beta,16beta,25-pentaol-3-O-beta-D-xylopyranoside","C000592398","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24458351","Effects of (20S*,24R*)-epoxy-9,19-cyclolanstane-3β,12β,16β,25-pentaol-3-O-β-D-xylopyranoside extracted from rhizoma Beesia on immunoregulation and anti-inflammation.","24458351",136]
["(213)Bi-DTPA-F3","(213)Bi-DTPA-F3","C580872","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22872310","Enhanced efficacy of combined 213Bi-DTPA-F3 and paclitaxel therapy of peritoneal carcinomatosis is mediated by enhanced induction of apoptosis and G2/M phase arrest.","22872310",136]
["(23R)-26-deoxycimicifugoside","(23R)-26-deoxycimicifugoside","C540475","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2008,"18837314","[A new cycloartane triterpene saponin from rhizome of Actaea asiatica].","18837314",136]
["(24S)-ergostane-3beta,5alpha,6beta-triol","(24S)-ergostane-3beta,5alpha,6beta-triol","C586171","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"22889249","(24S)-ergostane-3β,5α,6β-triol from Hedyotis chrysotricha with inhibitory activity on migration of SK-HEP-1 human hepatocarcinoma cells.","22889249",136]
["(25R)-17alpha-hydroxyspitost-5-en-3beta-yl O-alpha-L-rhamnopyranosyl-(1-2)-O-(alpha-L-rhamnopyranosyl-(1-3))-4-O-acetyl-beta-D-glucopyranoside","(25R)-17alpha-hydroxyspitost-5-en-3beta-yl O-alpha-L-rhamnopyranosyl-(1-2)-O-(alpha-L-rhamnopyranosyl-(1-3))-4-O-acetyl-beta-D-glucopyranoside","C000594700","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"25152452","Steroidal glycosides from the underground parts of Dracaena thalioides and their cytotoxic activity.","25152452",136]
["(25S)-ruscogenin 1-sulfate-3-O-alpha-L-rhamnopyranoside","(25S)-ruscogenin 1-sulfate-3-O-alpha-L-rhamnopyranoside","C583591","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22812006","[A novel C27-steroidal glycoside sulfate from Liriope graminifolia].","22812006",136]
["(2-adamantyl)naphthol","(2-adamantyl)naphthol","C574741","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22533612","Sterically congested adamantylnaphthalene quinone methides.","22533612",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C323,B323)","v":"(2-boronoethyl)-cysteine"},"(2-boronoethyl)-cysteine","C425062","3_KE",870,3,"Cell Proliferation","Increase",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J323,K323)","v":"Cell Proliferation"},"D049109","Cell Proliferation",1,1,2015,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q323,Q323)","v":"26126810"},"Arginase inhibition protects against hypoxia‑induced pulmonary arterial hypertension.","26126810",136]
["(2E)-3-(2-naphtyl)-1-(3'-methoxy-4'-hydroxy-phenyl)-2-propen-1-one","(2E)-3-(2-naphtyl)-1-(3'-methoxy-4'-hydroxy-phenyl)-2-propen-1-one","C556214","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"20796191","Induction of apoptosis and cell cycle arrest in L-1210 murine lymphoblastic leukaemia cells by (2E)-3-(2-naphthyl)-1-(3'-methoxy-4'-hydroxy-phenyl)-2-propen-1-one.","20796191",136]
["(2E)-3-(4-hydroxy-3-methoxyphenyl) phenylpro-2-1-one","(2E)-3-(4-hydroxy-3-methoxyphenyl) phenylpro-2-1-one","C532465","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27348972","Anti-tumor activity of benzylideneacetophenone derivatives via proteasomal inhibition in prostate cancer cells.","27348972",136]
["(2E)-decenal","(2E)-decenal","C476489","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2003,"12822929","Modes of antifungal action of (2E)-alkenals against Saccharomyces cerevisiae.","12822929",136]
["(2E)-N,N-dibutyl-3-(4-hydroxy-3-methoxyphenyl)acrylamide","(2E)-N,N-dibutyl-3-(4-hydroxy-3-methoxyphenyl)acrylamide","C518368","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2007,"17352252","(2E)-N,N-dibutyl-3-(4-hydroxy-3-methoxyphenyl)acrylamide induces apoptosis and cell cycle arrest in HL-60 cells.","17352252",136]
["(2E)-undecenal","(2E)-undecenal","C476488","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2003,"12822929","Modes of antifungal action of (2E)-alkenals against Saccharomyces cerevisiae.","12822929",136]
["(2E,2'E)-1,1'-(3-hydroxy-5-methylbiphenyl-2,6-diyl)bis(3-(3-chlorophenyl)prop-2-en-1-one)","(2E,2'E)-1,1'-(3-hydroxy-5-methylbiphenyl-2,6-diyl)bis(3-(3-chlorophenyl)prop-2-en-1-one)","C559238","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2010,"20605470","Synthesis and anti breast cancer activity of biphenyl based chalcones.","20605470",136]
["(2E,2'E)-1,1'-(4'-chloro-3-hydroxy-5-methylbiphenyl-2,6-diyl)bis(3-phenylprop-2-en-1-one)","(2E,2'E)-1,1'-(4'-chloro-3-hydroxy-5-methylbiphenyl-2,6-diyl)bis(3-phenylprop-2-en-1-one)","C559237","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2010,"20605470","Synthesis and anti breast cancer activity of biphenyl based chalcones.","20605470",136]
["(2E,4E,6E,10E)-3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid","(2E,4E,6E,10E)-3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid","C487689","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2006,"16546985","NIK-333 inhibits growth of human T-cell leukemia virus type I-infected T-cell lines and adult T-cell leukemia cells in association with blockade of nuclear factor-kappaB signal pathway.","16546985",136]
["(2E,4E,6E,10E)-3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid","(2E,4E,6E,10E)-3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid","C487689","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"20676681","Synergistic growth inhibition in HL-60 cells by the combination of acyclic retinoid and vitamin K2.","20676681",136]
["(2E,4E,6E,10E)-3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid","(2E,4E,6E,10E)-3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid","C487689","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20460176","Chemopreventive anti-cancer agent acyclic retinoid suppresses allogeneic immune responses in rats.","20460176",136]
["(2E,4E,6E,10E)-3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid","(2E,4E,6E,10E)-3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid","C487689","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"20676681","Synergistic growth inhibition in HL-60 cells by the combination of acyclic retinoid and vitamin K2.","20676681",136]
["(2-fluoro-2',5'-dimethyl-4'-(6-(3-methyl-2-butenyloxy)pyridin-3-yl) biphenyl-4-yl)-(3-methyl-2-butenyl)amine","(2-fluoro-2',5'-dimethyl-4'-(6-(3-methyl-2-butenyloxy)pyridin-3-yl) biphenyl-4-yl)-(3-methyl-2-butenyl)amine","C538781","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2008,"18834876","Suppression of immunoglobulin production by a novel dihydroorotate dehydrogenase inhibitor, S-2678.","18834876",136]
["(2-fluorobenzyl)-(2-methyl-2-phenyl-2H-chromen-6-yl-amine)","(2-fluorobenzyl)-(2-methyl-2-phenyl-2H-chromen-6-yl-amine)","C558761","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2011,"21287578","An activator of PHD2, KRH102140, decreases angiogenesis via inhibition of HIF-1α.","21287578",136]
["(2-hydroxy-3-methoxybenzoyl-2-aminoethyl)-bis(2,3-dihydroxybenzoyl-2-aminoethyl)amine","(2-hydroxy-3-methoxybenzoyl-2-aminoethyl)-bis(2,3-dihydroxybenzoyl-2-aminoethyl)amine","C420445","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2000,"11196825","Catecholate/salicylate heteropodands: demonstration of a catecholate to salicylate coordination change.","11196825",136]
["(2-hydroxy-5-methoxyphenyl)(9H-pyrido(2,3-b)indol-3-yl)methanone","(2-hydroxy-5-methoxyphenyl)(9H-pyrido(2,3-b)indol-3-yl)methanone","C000605533","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25840421","Dual targeting of microtubule and topoisomerase II by α-carboline derivative YCH337 for tumor proliferation and growth inhibition.","25840421",136]
["(2-hydroxyaminovinyl)triphenylphosphonium","(2-hydroxyaminovinyl)triphenylphosphonium","C528230","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2008,"18258194","Activation of NO donors in mitochondria: peroxidase metabolism of (2-hydroxyamino-vinyl)-triphenyl-phosphonium by cytochrome c releases NO and protects cells against apoptosis.","18258194",136]
["(2-hydroxyaminovinyl)triphenylphosphonium","(2-hydroxyaminovinyl)triphenylphosphonium","C528230","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2009,"19427865","Mitochondria-targeted (2-hydroxyamino-vinyl)-triphenyl-phosphonium releases NO(.) and protects mouse embryonic cells against irradiation-induced apoptosis.","19427865",136]
["(2-hydroxybenzoyl-2-aminoethyl)-bis(2,3-dihydroxybenzoyl-2-aminoethyl)amine","(2-hydroxybenzoyl-2-aminoethyl)-bis(2,3-dihydroxybenzoyl-2-aminoethyl)amine","C420444","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2000,"11196825","Catecholate/salicylate heteropodands: demonstration of a catecholate to salicylate coordination change.","11196825",136]
["(2-hydroxyethyl) trimethylammonium hydroxide","(2-hydroxyethyl) trimethylammonium hydroxide","C528098","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2010,"20035850","Novel pH-sensitive microgels prepared using salt bridge.","20035850",136]
["(2-methyl-4-phenyl-4H-benzo(4,5)thiazolo(3,2-a)pyrimidin-3-yl)(4-methylpiperazin-1-yl)methanone","(2-methyl-4-phenyl-4H-benzo(4,5)thiazolo(3,2-a)pyrimidin-3-yl)(4-methylpiperazin-1-yl)methanone","C000589304","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"24113366","Synthesis of novel benzo[4,5]thiazolo[1,2-a]pyrimidine-3-carboxylate derivatives and biological evaluation as potential anticancer agents.","24113366",136]
["(2-methyl-n-butyl)shikonin","(2-methyl-n-butyl)shikonin","C583586","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22919733","[Mechanisms of (2-methyl-n-butyl) shikonin induced apoptosis of gastric cancer SGC-7901 cells].","22919733",136]
["(2-methyl-n-butyl)shikonin","(2-methyl-n-butyl)shikonin","C583586","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22919733","[Mechanisms of (2-methyl-n-butyl) shikonin induced apoptosis of gastric cancer SGC-7901 cells].","22919733",136]
["(2-phenylthiazol-4-yl)-(3,4,5-trimethoxyphenyl)methanone","(2-phenylthiazol-4-yl)-(3,4,5-trimethoxyphenyl)methanone","C550330","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"20060430","Synthesis, formulation and in vitro evaluation of a novel microtubule destabilizer, SMART-100.","20060430",136]
["(2-phenylthiazol-4-yl)-(3,4,5-trimethoxyphenyl)methanone","(2-phenylthiazol-4-yl)-(3,4,5-trimethoxyphenyl)methanone","C550330","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20060430","Synthesis, formulation and in vitro evaluation of a novel microtubule destabilizer, SMART-100.","20060430",136]
["(2R,3R)-3,5-dihydroxy-7-methoxyflavanone 3-(2-methyl)butyrate","(2R,3R)-3,5-dihydroxy-7-methoxyflavanone 3-(2-methyl)butyrate","C549662","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2010,"20307087","Study on the constituents of Mexican propolis and their cytotoxic activity against PANC-1 human pancreatic cancer cells.","20307087",136]
["(2R,3S)-3',4',5,7-tetrahydroxyflavan-3-yl octadecanoate","(2R,3S)-3',4',5,7-tetrahydroxyflavan-3-yl octadecanoate","C509175","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2006,"16460233","Catechin conjugated with fatty acid inhibits DNA polymerase and angiogenesis.","16460233",136]
["(2R,3S)-pinobanksin-3-cinnamate","(2R,3S)-pinobanksin-3-cinnamate","C000591505","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25808015","(2R,3S)-Pinobanksin-3-cinnamate improves cognition and reduces oxidative stress in rats with vascular dementia.","25808015",136]
["(2R,3Z)-N-(1-hydroxyoctadec-3-en-2-yl)pivalamide","(2R,3Z)-N-(1-hydroxyoctadec-3-en-2-yl)pivalamide","C559741","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"21557271","Inhibition of acid ceramidase by a 2-substituted aminoethanol amide synergistically sensitizes prostate cancer cells to N-(4-hydroxyphenyl) retinamide.","21557271",136]
["(2S)-2-(4-(((3S)-1-acetimidoyl-3-pyrrolidinyl)oxy)phenyl)-3-(7-amidino-2-naphtyl)propanoic acid","(2S)-2-(4-(((3S)-1-acetimidoyl-3-pyrrolidinyl)oxy)phenyl)-3-(7-amidino-2-naphtyl)propanoic acid","C086910","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2013,"24118066","Cyclodextrins improve oral absorption of a novel factor Xa inhibitor by interfering with interaction between the drug and bile acids in rats.","24118066",136]
["(2S)-2-(4-(((3S)-1-acetimidoyl-3-pyrrolidinyl)oxy)phenyl)-3-(7-amidino-2-naphtyl)propanoic acid","(2S)-2-(4-(((3S)-1-acetimidoyl-3-pyrrolidinyl)oxy)phenyl)-3-(7-amidino-2-naphtyl)propanoic acid","C086910","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1998,"9468645","Photodecarboxylation of DX-9065a, a new factor Xa inhibitor, in aqueous solution.","9468645",136]
["(2'S)-columbianetin-3'-sulfate","(2'S)-columbianetin-3'-sulfate","C548752","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"20026161","Constituents of Corydalis heterocarpa and their anti-proliferative effects on human cancer cells.","20026161",136]
["(2''S,3aR,6S,7aR)-3''-acetyl-3a,7a-dihydro-2,2,2'-2',-tetramethyl-5'-(4-bromophenyl)-spiro(spiro(1,3-dioxolo(4,5-D)-pyrane-6(7H),5'(4'H)-1',3'-dioxolo)-7(6H),2''(3''H)-(1,3,4)-oxadiazole)","(2''S,3aR,6S,7aR)-3''-acetyl-3a,7a-dihydro-2,2,2'-2',-tetramethyl-5'-(4-bromophenyl)-spiro(spiro(1,3-dioxolo(4,5-D)-pyrane-6(7H),5'(4'H)-1',3'-dioxolo)-7(6H),2''(3''H)-(1,3,4)-oxadiazole)","C512376","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2005,"15960897","GLB prevents tumor metastasis of Lewis lung carcinoma by inhibiting tumor adhesion actions.","15960897",136]
["(2S,3S)-pterosin C 3-O-beta-D-(40-(E)-caffeoyl)-glucopyranoside","(2S,3S)-pterosin C 3-O-beta-D-(40-(E)-caffeoyl)-glucopyranoside","C000622494","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28532669","Cytotoxic pterosins from Pteris multifida roots against HCT116 human colon cancer cells.","28532669",136]
["(2S,3S)-pterosin C 3-O-beta-D-(6'-(E)-p-coumaroyl)-glucopyranoside","(2S,3S)-pterosin C 3-O-beta-D-(6'-(E)-p-coumaroyl)-glucopyranoside","C000622495","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28532669","Cytotoxic pterosins from Pteris multifida roots against HCT116 human colon cancer cells.","28532669",136]
["(2S,3S,4R,8Z)-1-O-(beta-D-galactopyranosyl)-2N-((2'R)-2'-hydroxypentacosanoilamino)8(Z)-octadecene-1,3,4-triol","(2S,3S,4R,8Z)-1-O-(beta-D-galactopyranosyl)-2N-((2'R)-2'-hydroxypentacosanoilamino)8(Z)-octadecene-1,3,4-triol","C550892","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"19703528","Cerebrosides with antiproliferative activity from Euphorbia peplis L.","19703528",136]
["(2S,4R)-methyl-1-acetyl-4-(N-(4-bromophenyl)sulfamoyloxy)pyrrolidine-2-carboxylate","(2S,4R)-methyl-1-acetyl-4-(N-(4-bromophenyl)sulfamoyloxy)pyrrolidine-2-carboxylate","C560356","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21349324","N1-acetyl substituted pyrrolidine derivative CIP-A5: a novel compound that could ameliorate liver cirrhosis through modulation of hepatic stellate cell activity.","21349324",136]
["(2S,4S,10R)-4-(3-hydroxy-4-methoxyphenyl)-quinolizidin-2-acetate","(2S,4S,10R)-4-(3-hydroxy-4-methoxyphenyl)-quinolizidin-2-acetate","C531207","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2008,"18374955","Alkaloids from Heimia salicifolia.","18374955",136]
["(2'S,7'S)-O-2-methylbutanoyl-columbianetin","(2'S,7'S)-O-2-methylbutanoyl-columbianetin","C548753","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"20026161","Constituents of Corydalis heterocarpa and their anti-proliferative effects on human cancer cells.","20026161",136]
["(3-((2,3,4,5-tetrahydroxyhexane-1,6-diyl)))di-1H-imidazole","(3-((2,3,4,5-tetrahydroxyhexane-1,6-diyl)))di-1H-imidazole","C523912","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"17691761","Novel generation of pH indicators for proton magnetic resonance spectroscopic imaging.","17691761",136]
["(3-((2,3-dihydroxybutane-1,4-diyl)))-di-1H-imidazole","(3-((2,3-dihydroxybutane-1,4-diyl)))-di-1H-imidazole","C523911","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"17691761","Novel generation of pH indicators for proton magnetic resonance spectroscopic imaging.","17691761",136]
["(3-(1H-indol-2-yl)phenyl)(1H-indol-2-yl)methanone","(3-(1H-indol-2-yl)phenyl)(1H-indol-2-yl)methanone","C557277","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"20383708","A novel bis-indole destabilizes microtubules and displays potent in vitro and in vivo antitumor activity in prostate cancer.","20383708",136]
["(3-(1H-indol-2-yl)phenyl)(1H-indol-2-yl)methanone","(3-(1H-indol-2-yl)phenyl)(1H-indol-2-yl)methanone","C557277","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"20383708","A novel bis-indole destabilizes microtubules and displays potent in vitro and in vivo antitumor activity in prostate cancer.","20383708",136]
["(3-(1H-indol-2-yl)phenyl)(1H-indol-2-yl)methanone","(3-(1H-indol-2-yl)phenyl)(1H-indol-2-yl)methanone","C557277","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22576690","Pharmacokinetics, pharmacodynamics and metabolism of a novel anticancer             agent for prostate cancer.","22576690",136]
["(3-(1H-indol-2-yl)phenyl)(3,4,5-trimethoxyphenyl)methanone","(3-(1H-indol-2-yl)phenyl)(3,4,5-trimethoxyphenyl)methanone","C556166","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"20829196","I-387, a novel antimitotic indole, displays a potent in vitro and in vivo antitumor activity with less neurotoxicity.","20829196",136]
["(3-(2,6-dichloro-phenylamino)phenyl)acetic acid 2-methanesulphonylsulphanyl ethyl ester","(3-(2,6-dichloro-phenylamino)phenyl)acetic acid 2-methanesulphonylsulphanyl ethyl ester","C573319","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"21955294","Hydrogen sulphide-releasing diclofenac derivatives inhibit breast cancer-induced osteoclastogenesis in vitro and prevent osteolysis ex vivo.","21955294",136]
["(3-(4-tolylamino)-5-amino-1H-1,2,4-triazol-1-yl)(3,4,5-trimethoxyphenyl)methanone","(3-(4-tolylamino)-5-amino-1H-1,2,4-triazol-1-yl)(3,4,5-trimethoxyphenyl)methanone","C000595013","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"25025853","Synthesis, antimitotic and antivascular activity of 1-(3',4',5'-trimethoxybenzoyl)-3-arylamino-5-amino-1,2,4-triazoles.","25025853",136]
["(3-(4-tolylamino)-5-amino-1H-1,2,4-triazol-1-yl)(3,4,5-trimethoxyphenyl)methanone","(3-(4-tolylamino)-5-amino-1H-1,2,4-triazol-1-yl)(3,4,5-trimethoxyphenyl)methanone","C000595013","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"25025853","Synthesis, antimitotic and antivascular activity of 1-(3',4',5'-trimethoxybenzoyl)-3-arylamino-5-amino-1,2,4-triazoles.","25025853",136]
["(3-(benzyloxy)-4-methoxyphenyl)(5,6,7-trimethoxy-1-methyl-1H-indol-3-yl)methanone","(3-(benzyloxy)-4-methoxyphenyl)(5,6,7-trimethoxy-1-methyl-1H-indol-3-yl)methanone","C582560","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23360369","Synthesis and structure-activity relationships of N-methyl-5,6,7-trimethoxylindoles as novel antimitotic and vascular disrupting agents.","23360369",136]
["(3,10-dihydroxybenz(c)xanthene-7-yl)-4-carboxy-2-methylbenzene","(3,10-dihydroxybenz(c)xanthene-7-yl)-4-carboxy-2-methylbenzene","C533355","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2008,"18841988","Nonclassical SNAPFL analogue as a Cy5 resonance energy transfer partner.","18841988",136]
["(3,3')spiro((hexahydropyrrolo(1,2-a)pyrazine-1,4-dione)-6,3'-(2',3'-dihydrothieno(2,3-b)naphtho-4',9'-dione))","(3,3')spiro((hexahydropyrrolo(1,2-a)pyrazine-1,4-dione)-6,3'-(2',3'-dihydrothieno(2,3-b)naphtho-4',9'-dione))","C553169","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"20590589","A novel quinone-based derivative (DTNQ-Pro) induces apoptotic death via modulation of heat shock protein expression in Caco-2 cells.","20590589",136]
["(3,3')spiro((hexahydropyrrolo(1,2-a)pyrazine-1,4-dione)-6,3'-(2',3'-dihydrothieno(2,3-b)naphtho-4',9'-dione))","(3,3')spiro((hexahydropyrrolo(1,2-a)pyrazine-1,4-dione)-6,3'-(2',3'-dihydrothieno(2,3-b)naphtho-4',9'-dione))","C553169","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20590589","A novel quinone-based derivative (DTNQ-Pro) induces apoptotic death via modulation of heat shock protein expression in Caco-2 cells.","20590589",136]
["(3,3'-diphenyl-1,1'-binaphthyl)-20-crown-6","(3,3'-diphenyl-1,1'-binaphthyl)-20-crown-6","C530035","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2008,"18539184","Liquid chromatographic resolution of beta-amino acids on CSPs based on optically active (3,3'-diphenyl-1,1'-binaphthyl)-20-crown-6.","18539184",136]
["(3,4-dihydroxyphenylamino)-2-imidazoline","(3,4-dihydroxyphenylamino)-2-imidazoline","C011775","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2003,"12962151","Differential effects of vitamin E and three hydrophilic antioxidants on the actinomycin D-induced and colcemid-accelerated apoptosis in human leukemia CMK-7 cell line.","12962151",136]
["(3,4-dihydroxyphenylamino)-2-imidazoline","(3,4-dihydroxyphenylamino)-2-imidazoline","C011775","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1998,"9862437","Probing cellular protein targets of H2O2 with fluorescein-conjugated iodoacetamide and antibodies to fluorescein.","9862437",136]
["(3,5,6-trimethylpyrazin-2-yl)methyl 2-(4-(2-methylpropyl)phenyl)propanoate","(3,5,6-trimethylpyrazin-2-yl)methyl 2-(4-(2-methylpropyl)phenyl)propanoate","C495410","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Atrophy","D001284","Atrophy",1,2,2006,"16545771","A potential endogenous ligand for the aryl hydrocarbon receptor has potent agonist activity in vitro and in vivo.","16545771",136]
["(3,5-bis((4-fluorophenyl)methylidene)-1-((1-hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl)piperidin-4-one)","(3,5-bis((4-fluorophenyl)methylidene)-1-((1-hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl)piperidin-4-one)","C541427","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2009,"19276401","Inhibition of vascular smooth-muscle cell proliferation and arterial restenosis by HO-3867, a novel synthetic curcuminoid, through up-regulation of PTEN expression.","19276401",136]
["(3,5-bis((4-fluorophenyl)methylidene)-1-((1-hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl)piperidin-4-one)","(3,5-bis((4-fluorophenyl)methylidene)-1-((1-hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl)piperidin-4-one)","C541427","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"21885917","HO-3867, a curcumin analog, sensitizes cisplatin-resistant ovarian carcinoma, leading to therapeutic synergy through STAT3 inhibition.","21885917",136]
["(3,5-bis((4-fluorophenyl)methylidene)-1-((1-hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl)piperidin-4-one)","(3,5-bis((4-fluorophenyl)methylidene)-1-((1-hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl)piperidin-4-one)","C541427","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22801507","HO-3867, a STAT3 inhibitor induces apoptosis by inactivation of STAT3 activity in BRCA1-mutated ovarian cancer cells.","22801507",136]
["(3,5-bis((4-fluorophenyl)methylidene)-1-((1-hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl)piperidin-4-one)","(3,5-bis((4-fluorophenyl)methylidene)-1-((1-hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl)piperidin-4-one)","C541427","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24590057","HO-3867, a safe STAT3 inhibitor, is selectively cytotoxic to ovarian cancer.","24590057",136]
["(3,5-bis((4-fluorophenyl)methylidene)-1-((1-hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl)piperidin-4-one)","(3,5-bis((4-fluorophenyl)methylidene)-1-((1-hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl)piperidin-4-one)","C541427","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28067673","A novel STAT3 inhibitor HO-3867 induces cell apoptosis by reactive oxygen species-dependent endoplasmic reticulum stress in human pancreatic cancer cells.","28067673",136]
["(3,5-bis((4-fluorophenyl)methylidene)-1-((1-hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl)piperidin-4-one)","(3,5-bis((4-fluorophenyl)methylidene)-1-((1-hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl)piperidin-4-one)","C541427","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28646535","Targeting STAT3 by HO3867 induces apoptosis in ovarian clear cell carcinoma.","28646535",136]
["(3,5-bis((4-fluorophenyl)methylidene)-1-((1-hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl)piperidin-4-one)","(3,5-bis((4-fluorophenyl)methylidene)-1-((1-hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl)piperidin-4-one)","C541427","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"19276401","Inhibition of vascular smooth-muscle cell proliferation and arterial restenosis by HO-3867, a novel synthetic curcuminoid, through up-regulation of PTEN expression.","19276401",136]
["(3,5-bis((4-fluorophenyl)methylidene)-1-((1-hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl)piperidin-4-one)","(3,5-bis((4-fluorophenyl)methylidene)-1-((1-hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl)piperidin-4-one)","C541427","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21885917","HO-3867, a curcumin analog, sensitizes cisplatin-resistant ovarian carcinoma, leading to therapeutic synergy through STAT3 inhibition.","21885917",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C387,B387)","v":"(3,5-bis((4-fluorophenyl)methylidene)-1-((1-hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl)piperidin-4-one)"},"(3,5-bis((4-fluorophenyl)methylidene)-1-((1-hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl)piperidin-4-one)","C541427","3_KE",870,3,"Cell Proliferation","Increase",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J387,K387)","v":"Cell Proliferation"},"D049109","Cell Proliferation",1,2,2012,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q387,Q387)","v":"22801507"},"HO-3867, a STAT3 inhibitor induces apoptosis by inactivation of STAT3 activity in BRCA1-mutated ovarian cancer cells.","22801507",136]
["(3,5-bis((4-fluorophenyl)methylidene)-1-((1-hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl)piperidin-4-one)","(3,5-bis((4-fluorophenyl)methylidene)-1-((1-hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl)piperidin-4-one)","C541427","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28646535","Targeting STAT3 by HO3867 induces apoptosis in ovarian clear cell carcinoma.","28646535",136]
["(3,6-dimethyl-2-(2,4,6-trimethylphenoxy)pyridin-4-yl)(1-ethylpropyl)amine","(3,6-dimethyl-2-(2,4,6-trimethylphenoxy)pyridin-4-yl)(1-ethylpropyl)amine","C529296","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,1,2015,"26159865","Conformational thermostabilisation of corticotropin releasing factor receptor 1.","26159865",136]
["(3alpha,5beta,17beta)-3-hydroxy-18-norandrostane-17-carbonitrile","(3alpha,5beta,17beta)-3-hydroxy-18-norandrostane-17-carbonitrile","C495276","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,1,2004,"15146041","Neuroactive steroids have multiple actions to potentiate GABAA receptors.","15146041",136]
["(3-amino-4-methoxyphenyl)(2-hydroxy-3,4,5-trimethoxyphenyl)methanone","(3-amino-4-methoxyphenyl)(2-hydroxy-3,4,5-trimethoxyphenyl)methanone","C000593389","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24657567","Antimitotic and vascular disrupting agents: 2-hydroxy-3,4,5-trimethoxybenzophenones.","24657567",136]
["(3-aminopropyl)dimethylethoxysilane","(3-aminopropyl)dimethylethoxysilane","C582385","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2013,"23305497","Characterization of three amino-functionalized surfaces and evaluation of antibody immobilization for the multiplex detection of tumor markers involved in colorectal cancer.","23305497",136]
["(3-aminopropyl)dimethylmethoxysilane","(3-aminopropyl)dimethylmethoxysilane","C543126","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2009,"20355821","Adhesion forces controlled by chemical self-assembly and pH: application to robotic microhandling.","20355821",136]
["(3-chloro-2-hydroxypropyl)trimethylammonium chloride","(3-chloro-2-hydroxypropyl)trimethylammonium chloride","C496948","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2009,"19428476","Antibacterial activity of quaternary ammonium chitosan containing mono or disaccharide moieties: preparation and characterization.","19428476",136]
["(3-chloro-2-hydroxypropyl)trimethylammonium chloride","(3-chloro-2-hydroxypropyl)trimethylammonium chloride","C496948","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"22609712","Adsorption of anionic dyes from aqueous solutions using chemically modified straw.","22609712",136]
["(3-chloro-2-hydroxypropyl)trimethylammonium chloride","(3-chloro-2-hydroxypropyl)trimethylammonium chloride","C496948","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"25146316","Flocculation of algal cells by amphoteric chitosan-based flocculant.","25146316",136]
["(3-chloro-4-fluoro-phenyl)-(6-(4-diethylaminomethyl-piperidin-1yl)-pyrimido(5,4-d)pyrimidin-4-yl)amine","(3-chloro-4-fluoro-phenyl)-(6-(4-diethylaminomethyl-piperidin-1yl)-pyrimido(5,4-d)pyrimidin-4-yl)amine","C495482","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"22753156","EGFR inhibitor BIBU induces apoptosis and defective autophagy in glioma cells.","22753156",136]
["(3-dimyristyloxypropyl)(dimethyl)(hydroxyethyl)ammonium","(3-dimyristyloxypropyl)(dimethyl)(hydroxyethyl)ammonium","C087276","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2005,"16051183","Effect of \"helper lipid\" on lipoplex electrostatics.","16051183",136]
["(3-ethyl-2-methyl-quinolin-6-yl)-(4-methoxycyclohexyl)methanone methanesulfonate","(3-ethyl-2-methyl-quinolin-6-yl)-(4-methoxycyclohexyl)methanone methanesulfonate","C502015","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22144346","Selective mGluR1 antagonist EMQMCM inhibits the kainate-induced excitotoxicity in primary neuronal cultures and in the rat hippocampus.","22144346",136]
["(3-hydroxy-4-methoxyphenyl)(2-hydroxy-3,4,5-trimethoxyphenyl)methanone","(3-hydroxy-4-methoxyphenyl)(2-hydroxy-3,4,5-trimethoxyphenyl)methanone","C000593388","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24657567","Antimitotic and vascular disrupting agents: 2-hydroxy-3,4,5-trimethoxybenzophenones.","24657567",136]
["(3-isocyanatopropyl) triethoxysilane","(3-isocyanatopropyl) triethoxysilane","C492426","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2004,"14962563","Ethoxysilane-capped PEO-PPO-PEO triblocks: a new family of reverse thermo-responsive polymers.","14962563",136]
["(3-mercaptopropyl)trimethoxysilane","(3-mercaptopropyl)trimethoxysilane","C102833","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2008,"17980481","Ni(II) removal from aqueous effluents by silylated clays.","17980481",136]
["(3-mercaptopropyl)trimethoxysilane","(3-mercaptopropyl)trimethoxysilane","C102833","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2009,"19513492","Colorimetric sensing of pyrophosphate in aqueous media using bis-functionalised silica surfaces.","19513492",136]
["(3-mercaptopropyl)trimethoxysilane","(3-mercaptopropyl)trimethoxysilane","C102833","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2009,"19647836","Synthesis of MPTS-modified cobalt ferrite nanoparticles and their adsorption properties in relation to Au(III).","19647836",136]
["(3-mercaptopropyl)trimethoxysilane","(3-mercaptopropyl)trimethoxysilane","C102833","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"22204936","Polymeric ionic liquid modified organic-silica hybrid monolithic column for capillary electrochromatography.","22204936",136]
["(3-mercaptopropyl)trimethoxysilane","(3-mercaptopropyl)trimethoxysilane","C102833","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"22444573","Cadmium (II) imprinted 3-mercaptopropyltrimethoxysilane coated stir bar for selective extraction of trace cadmium from environmental water samples followed by inductively coupled plasma mass spectrometry detection.","22444573",136]
["(3-mercaptopropyl)trimethoxysilane","(3-mercaptopropyl)trimethoxysilane","C102833","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"23158690","Grafting 3-mercaptopropyl trimethoxysilane on multi-walled carbon nanotubes surface for improving on-line cadmium(II) preconcentration from water samples.","23158690",136]
["(3-mercaptopropyl)trimethoxysilane","(3-mercaptopropyl)trimethoxysilane","C102833","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2013,"24209374","Synthesis and characterization of poly[1-(N,N-bis-carboxymethyl)amino-3-allylglycerol-co-dimethylacrylamide] grafted to magnetic nano-particles for extraction and determination of letrozole in biological and pharmaceutical samples.","24209374",136]
["(3-mercaptopropyl)trimethoxysilane","(3-mercaptopropyl)trimethoxysilane","C102833","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2016,"27441858","Removal of nickel and cadmium heavy metals using nanofiber membranes functionalized with (3-mercaptopropyl)trimethoxysilane (TMPTMS).","27441858",136]
["(3-methylbutyryl)urea","(3-methylbutyryl)urea","C119881","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1999,"10197421","Debromination of (alpha-bromoiso-valeryl)urea catalysed by rat blood.","10197421",136]
["(3-oxo-4-methylazaandrost-1-ene-17-yl)-2,2,2-trifluoroethyl ester carbamic acid","(3-oxo-4-methylazaandrost-1-ene-17-yl)-2,2,2-trifluoroethyl ester carbamic acid","C000594012","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24565564","Identification of an anabolic selective androgen receptor modulator that actively induces death of androgen-independent prostate cancer cells.","24565564",136]
["(3-oxo-4-methylazaandrost-1-ene-17-yl)-2,2,2-trifluoroethyl ester carbamic acid","(3-oxo-4-methylazaandrost-1-ene-17-yl)-2,2,2-trifluoroethyl ester carbamic acid","C000594012","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24565564","Identification of an anabolic selective androgen receptor modulator that actively induces death of androgen-independent prostate cancer cells.","24565564",136]
["(3S,4aR,7S)-7,8-dihydroxy-3-methyl-3,4,10,5,6,7-hexahydro-1H-isochromen-1-one","(3S,4aR,7S)-7,8-dihydroxy-3-methyl-3,4,10,5,6,7-hexahydro-1H-isochromen-1-one","C579826","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23387901","Tubulin inhibitors from an endophytic fungus isolated from Cedrus deodara.","23387901",136]
["(3Z)-3-(1H-pyrrol-2-yl)-methyllidene)-1-(1-(piperidylmethyl)-1,3-dihydro-2H-indol-2-one mesylate","(3Z)-3-(1H-pyrrol-2-yl)-methyllidene)-1-(1-(piperidylmethyl)-1,3-dihydro-2H-indol-2-one mesylate","C504089","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2005,"15840953","Angiogenesis inhibitor Z24 induces endothelial cell apoptosis and suppresses tumor growth and metastasis.","15840953",136]
["(3Z)-3-(1H-pyrrol-2-yl)-methyllidene)-1-(1-(piperidylmethyl)-1,3-dihydro-2H-indol-2-one mesylate","(3Z)-3-(1H-pyrrol-2-yl)-methyllidene)-1-(1-(piperidylmethyl)-1,3-dihydro-2H-indol-2-one mesylate","C504089","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"20495136","Toxicological evaluation of z24, a novel indolin-2-ketone compound, in cultured human liver cells using toxicogenomic techniques.","20495136",136]
["(3Z)-3-(1H-pyrrol-2-yl)-methyllidene)-1-(1-(piperidylmethyl)-1,3-dihydro-2H-indol-2-one mesylate","(3Z)-3-(1H-pyrrol-2-yl)-methyllidene)-1-(1-(piperidylmethyl)-1,3-dihydro-2H-indol-2-one mesylate","C504089","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2010,"20544730","Plasma and liver proteomic analysis of 3Z-3-[(1H-pyrrol-2-yl)-methylidene]-1-(1-piperidinylmethyl)-1,3-2H-indol-2-one-induced hepatotoxicity in Wistar rats.","20544730",136]
["(3Z)-3-(1H-pyrrol-2-yl)-methyllidene)-1-(1-(piperidylmethyl)-1,3-dihydro-2H-indol-2-one mesylate","(3Z)-3-(1H-pyrrol-2-yl)-methyllidene)-1-(1-(piperidylmethyl)-1,3-dihydro-2H-indol-2-one mesylate","C504089","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2005,"15840953","Angiogenesis inhibitor Z24 induces endothelial cell apoptosis and suppresses tumor growth and metastasis.","15840953",136]
["(4-(((4-(4-(2-chlorophenyl)-1-piperazinyl)-6-phenyl-2-pyrimidinyl)thio)methyl)-benzoic acid)","(4-(((4-(4-(2-chlorophenyl)-1-piperazinyl)-6-phenyl-2-pyrimidinyl)thio)methyl)-benzoic acid)","C000612188","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"26721593","Sulfiredoxin inhibitor induces preferential death of cancer cells through reactive oxygen species-mediated mitochondrial damage.","26721593",136]
["(4-((1-(3-fluorophenyl)methyl)-1H-indazol-5-ylamino)-5-methylpyrrolo(2,1-f)(1,2,4)triazin-6-yl)carbamic acid 3-morpholinylmethyl ester","(4-((1-(3-fluorophenyl)methyl)-1H-indazol-5-ylamino)-5-methylpyrrolo(2,1-f)(1,2,4)triazin-6-yl)carbamic acid 3-morpholinylmethyl ester","C545531","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"20119866","AC480, formerly BMS-599626, a pan Her inhibitor, enhances radiosensitivity and radioresponse of head and neck squamous cell carcinoma cells in vitro and in vivo.","20119866",136]
["(4-((1-(3-fluorophenyl)methyl)-1H-indazol-5-ylamino)-5-methylpyrrolo(2,1-f)(1,2,4)triazin-6-yl)carbamic acid 3-morpholinylmethyl ester","(4-((1-(3-fluorophenyl)methyl)-1H-indazol-5-ylamino)-5-methylpyrrolo(2,1-f)(1,2,4)triazin-6-yl)carbamic acid 3-morpholinylmethyl ester","C545531","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"20119866","AC480, formerly BMS-599626, a pan Her inhibitor, enhances radiosensitivity and radioresponse of head and neck squamous cell carcinoma cells in vitro and in vivo.","20119866",136]
["(4-((5,6-diphenylpyrazin-2-yl)(isopropyl)amino)butoxy)acetic acid","(4-((5,6-diphenylpyrazin-2-yl)(isopropyl)amino)butoxy)acetic acid","C531934","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28476928","Selexipag Active Metabolite ACT-333679 Displays Strong Anticontractile and Antiremodeling Effects but Low β-Arrestin Recruitment and Desensitization Potential.","28476928",136]
["(4-(10, 13-dimethyl-3-methylsulfonyloxy-2,3,4,5,6,7,8,9,11,12,14,15,16, 17-tetradecahydro-1H-cyclopenta(a)phenanthren-17-yl)pentyl) methanesulfonate","(4-(10, 13-dimethyl-3-methylsulfonyloxy-2,3,4,5,6,7,8,9,11,12,14,15,16, 17-tetradecahydro-1H-cyclopenta(a)phenanthren-17-yl)pentyl) methanesulfonate","C544140","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2009,"19569129","ICAT as a potential enhancer of monocytic differentiation: implications from the comparative proteome analysis of the HL60 cell line stimulated by all-trans retinoic acid and NSC67657.","19569129",136]
["(4-(10, 13-dimethyl-3-methylsulfonyloxy-2,3,4,5,6,7,8,9,11,12,14,15,16, 17-tetradecahydro-1H-cyclopenta(a)phenanthren-17-yl)pentyl) methanesulfonate","(4-(10, 13-dimethyl-3-methylsulfonyloxy-2,3,4,5,6,7,8,9,11,12,14,15,16, 17-tetradecahydro-1H-cyclopenta(a)phenanthren-17-yl)pentyl) methanesulfonate","C544140","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2016,"27150989","[Effect of Inhibiting and Activating Wnt Signalling Pathway on NSC67657-inducing Monocytic Differentiation of HL-60 Cells].","27150989",136]
["(4-(10, 13-dimethyl-3-methylsulfonyloxy-2,3,4,5,6,7,8,9,11,12,14,15,16, 17-tetradecahydro-1H-cyclopenta(a)phenanthren-17-yl)pentyl) methanesulfonate","(4-(10, 13-dimethyl-3-methylsulfonyloxy-2,3,4,5,6,7,8,9,11,12,14,15,16, 17-tetradecahydro-1H-cyclopenta(a)phenanthren-17-yl)pentyl) methanesulfonate","C544140","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"19569129","ICAT as a potential enhancer of monocytic differentiation: implications from the comparative proteome analysis of the HL60 cell line stimulated by all-trans retinoic acid and NSC67657.","19569129",136]
["(4'-(10-methyl-9-anthryl)-2,2'-6',2''-terpyridine-6,6''-diyl)bis(methylenenitrilo) tetrakis(acetate)-Eu(3+)","(4'-(10-methyl-9-anthryl)-2,2'-6',2''-terpyridine-6,6''-diyl)bis(methylenenitrilo) tetrakis(acetate)-Eu(3+)","C522821","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2006,"17031957","A europium(III) complex as an efficient singlet oxygen luminescence probe.","17031957",136]
["(4-(2-(3,5-bis(ethoxycarbonyloxy)phenyl)vinyl)phenyl) ethyl carbonate","(4-(2-(3,5-bis(ethoxycarbonyloxy)phenyl)vinyl)phenyl) ethyl carbonate","C000608951","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"26851025","Antiproliferative and Pro-apoptotic Activities of a Novel Resveratrol Prodrug Against Jurkat CD4+ T-Cells.","26851025",136]
["(4-(2-(3,5-bis(ethoxycarbonyloxy)phenyl)vinyl)phenyl) ethyl carbonate","(4-(2-(3,5-bis(ethoxycarbonyloxy)phenyl)vinyl)phenyl) ethyl carbonate","C000608951","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"26851025","Antiproliferative and Pro-apoptotic Activities of a Novel Resveratrol Prodrug Against Jurkat CD4+ T-Cells.","26851025",136]
["(4-(3,5-bis-(2-(4-hydroxy-3-methoxy-phenyl)vinyl)-4,5-dihydro-pyrazol-1-yl)-phenyl)-(4-methyl-piperazin-1-yl)methanone","(4-(3,5-bis-(2-(4-hydroxy-3-methoxy-phenyl)vinyl)-4,5-dihydro-pyrazol-1-yl)-phenyl)-(4-methyl-piperazin-1-yl)methanone","C521695","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2007,"17559805","Development of a new Ca2+/calmodulin antagonist and its anti-proliferative activity against colorectal cancer cells.","17559805",136]
["(4-(3-chlorophenyl)piperazin-1-yl)(2-ethoxyphenyl)methanone","(4-(3-chlorophenyl)piperazin-1-yl)(2-ethoxyphenyl)methanone","C587628","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24338023","Novel piperazine-based compounds inhibit microtubule dynamics and sensitize colon cancer cells to tumor necrosis factor-induced apoptosis.","24338023",136]
["(4-(3-chlorophenyl)piperazin-1-yl)(2-ethoxyphenyl)methanone","(4-(3-chlorophenyl)piperazin-1-yl)(2-ethoxyphenyl)methanone","C587628","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27097159","Efficient Activation of Apoptotic Signaling during Mitotic Arrest with AK301.","27097159",136]
["(4-(4-(6-amino-5-(benzo(d)oxazol-2-yl)pyridin-3-yl)-1H-pyrazol-1-yl)piperidin-1-yl)ethanone","(4-(4-(6-amino-5-(benzo(d)oxazol-2-yl)pyridin-3-yl)-1H-pyrazol-1-yl)piperidin-1-yl)ethanone","C580772","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23348694","KRC-408, a novel c-Met inhibitor, suppresses cell proliferation and angiogenesis of gastric cancer.","23348694",136]
["(4-(4-(6-amino-5-(benzo(d)oxazol-2-yl)pyridin-3-yl)-1H-pyrazol-1-yl)piperidin-1-yl)ethanone","(4-(4-(6-amino-5-(benzo(d)oxazol-2-yl)pyridin-3-yl)-1H-pyrazol-1-yl)piperidin-1-yl)ethanone","C580772","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25895026","Sorafenib and DE605, a novel c-Met inhibitor, synergistically suppress hepatocellular carcinoma.","25895026",136]
["(4-(4-(6-amino-5-(benzo(d)oxazol-2-yl)pyridin-3-yl)-1H-pyrazol-1-yl)piperidin-1-yl)ethanone","(4-(4-(6-amino-5-(benzo(d)oxazol-2-yl)pyridin-3-yl)-1H-pyrazol-1-yl)piperidin-1-yl)ethanone","C580772","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23348694","KRC-408, a novel c-Met inhibitor, suppresses cell proliferation and angiogenesis of gastric cancer.","23348694",136]
["(4-(4'-chloro-2'-fluoro)phenylamino)-6,7-dimethylquinazoline","(4-(4'-chloro-2'-fluoro)phenylamino)-6,7-dimethylquinazoline","C575425","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22227235","Regulation of human thyroid follicular cell function by inhibition of vascular endothelial growth factor receptor signalling.","22227235",136]
["(4-(4-chlorophenyl)-6-((4-nitrophenoxy) methyl) morpholin-3-one)","(4-(4-chlorophenyl)-6-((4-nitrophenoxy) methyl) morpholin-3-one)","C521396","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2007,"17395471","Novel morpholin-3-one derivatives induced apoptosis and elevated the level of P53 and Fas in A549 lung cancer cells.","17395471",136]
["(4-(5-amino-4-carbamoylimidazol-1-yl)-2,3-dihydroxycyclopentyl) methyl phosphate","(4-(5-amino-4-carbamoylimidazol-1-yl)-2,3-dihydroxycyclopentyl) methyl phosphate","C559837","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"21315177","A novel PKC-ι inhibitor abrogates cell proliferation and induces apoptosis in neuroblastoma.","21315177",136]
["(4-(5-amino-4-carbamoylimidazol-1-yl)-2,3-dihydroxycyclopentyl) methyl phosphate","(4-(5-amino-4-carbamoylimidazol-1-yl)-2,3-dihydroxycyclopentyl) methyl phosphate","C559837","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21315177","A novel PKC-ι inhibitor abrogates cell proliferation and induces apoptosis in neuroblastoma.","21315177",136]
["(4-(7-(3,5-dimethyloxyphenyl)-1H-pyrazolo(3,4)pyridin-6-yl)-4-fluoro)benzene","(4-(7-(3,5-dimethyloxyphenyl)-1H-pyrazolo(3,4)pyridin-6-yl)-4-fluoro)benzene","C541943","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2009,"19383925","Kit inhibitor APcK110 induces apoptosis and inhibits proliferation of acute myeloid leukemia cells.","19383925",136]
["(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride","(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride","D008455","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,1,2008,"18723515","A novel mechanism of G protein-coupled receptor functional selectivity. Muscarinic partial agonist McN-A-343 as a bitopic orthosteric/allosteric ligand.","18723515",136]
["(4,11-bis(carboxymethyl)-1,4,8,11-tetraazabicyclo(6.6.2)hexadecane)copper(II)","(4,11-bis(carboxymethyl)-1,4,8,11-tetraazabicyclo(6.6.2)hexadecane)copper(II)","C483895","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2009,"19324273","(64)Cu-labeled CB-TE2A and diamsar-conjugated RGD peptide analogs for targeting angiogenesis: comparison of their biological activity.","19324273",136]
["(4,4'-diethylaminomethyl-2,2'-bipyridine)bis(2,2'-bipyridine)ruthenium(II)","(4,4'-diethylaminomethyl-2,2'-bipyridine)bis(2,2'-bipyridine)ruthenium(II)","C106537","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1997,"9177680","Long-lifetime metal-ligand pH probe.","9177680",136]
["(4,4-dimethyl-2,2-bipyridine)(acetylacetonate)copper(II)","(4,4-dimethyl-2,2-bipyridine)(acetylacetonate)copper(II)","C525246","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2008,"17390215","Casiopeina III-ia induces apoptosis in HCT-15 cells in vitro through caspase-dependent mechanisms and has antitumor effect in vivo.","17390215",136]
["(4,4-dimethyl-2,2-bipyridine)(acetylacetonate)copper(II)","(4,4-dimethyl-2,2-bipyridine)(acetylacetonate)copper(II)","C525246","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2008,"18521723","Casiopeinas IIgly and IIIia induce apoptosis in medulloblastoma cells.","18521723",136]
["(4,4-dimethyl-2,2-bipyridine)(acetylacetonate)copper(II)","(4,4-dimethyl-2,2-bipyridine)(acetylacetonate)copper(II)","C525246","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22540380","Copper compound induces autophagy and apoptosis of glioma cells by reactive oxygen species and JNK activation.","22540380",136]
["(4,4-dimethyl-2,2-bipyridine)(acetylacetonate)copper(II)","(4,4-dimethyl-2,2-bipyridine)(acetylacetonate)copper(II)","C525246","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2008,"17390215","Casiopeina III-ia induces apoptosis in HCT-15 cells in vitro through caspase-dependent mechanisms and has antitumor effect in vivo.","17390215",136]
["(4,4-dimethyl-2,2-bipyridine)(acetylacetonate)copper(II)","(4,4-dimethyl-2,2-bipyridine)(acetylacetonate)copper(II)","C525246","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28231523","Synergistic effects between a copper-based metal Casiopeína III-ia and cisplatin.","28231523",136]
["(4-amidinophenyl)methanesulfonyl fluoride","(4-amidinophenyl)methanesulfonyl fluoride","C027226","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2002,"12355148","SEP-1 - a subtilisin-like serine endopeptidase from germinated seeds of Hordeum vulgare L. cv. Morex.","12355148",136]
["(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)","(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)","C517041","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2006,"16733666","Non-apoptotic programmed cell death induced by a copper(II) complex in human fibrosarcoma cells.","16733666",136]
["(4-amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl)(2,3-difluoro-6-methoxyphenyl)methanone","(4-amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl)(2,3-difluoro-6-methoxyphenyl)methanone","C515235","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2006,"17121911","In vitro and in vivo activity of R547: a potent and selective cyclin-dependent kinase inhibitor currently in phase I clinical trials.","17121911",136]
["(4-amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl)(2,3-difluoro-6-methoxyphenyl)methanone","(4-amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl)(2,3-difluoro-6-methoxyphenyl)methanone","C515235","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2006,"17121911","In vitro and in vivo activity of R547: a potent and selective cyclin-dependent kinase inhibitor currently in phase I clinical trials.","17121911",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C451,B451)","v":"(4-amino-2-(thiophen-3-yl)thiazol-5-yl)(3,4,5-trimethoxyphenyl)methanone"},"(4-amino-2-(thiophen-3-yl)thiazol-5-yl)(3,4,5-trimethoxyphenyl)methanone","C575284","5_KE",768,5,"Cytotoxicity","Increase",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J451,K451)","v":"Apoptosis"},"D017209","Apoptosis",1,2,2012,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q451,Q451)","v":"22578111"},"Discovery and optimization of a series of 2-aryl-4-amino-5-(3',4',5'-trimethoxybenzoyl)thiazoles as novel anticancer agents.","22578111",136]
["(4-amino-2-(thiophen-3-yl)thiazol-5-yl)(3,4,5-trimethoxyphenyl)methanone","(4-amino-2-(thiophen-3-yl)thiazol-5-yl)(3,4,5-trimethoxyphenyl)methanone","C575284","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22578111","Discovery and optimization of a series of 2-aryl-4-amino-5-(3',4',5'-trimethoxybenzoyl)thiazoles as novel anticancer agents.","22578111",136]
["(4-benzylpiperazin-1-yl)acetic acid (3-allyl-2-hydroxybenzylidene)hydrazine","(4-benzylpiperazin-1-yl)acetic acid (3-allyl-2-hydroxybenzylidene)hydrazine","C514579","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2006,"16936720","Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy.","16936720",136]
["(4-benzylpiperazin-1-yl)acetic acid (3-allyl-2-hydroxybenzylidene)hydrazine","(4-benzylpiperazin-1-yl)acetic acid (3-allyl-2-hydroxybenzylidene)hydrazine","C514579","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2009,"19708658","Procaspase-3 activation as an anti-cancer strategy: structure-activity relationship of procaspase-activating compound 1 (PAC-1) and its cellular co-localization with caspase-3.","19708658",136]
["(4-benzylpiperazin-1-yl)acetic acid (3-allyl-2-hydroxybenzylidene)hydrazine","(4-benzylpiperazin-1-yl)acetic acid (3-allyl-2-hydroxybenzylidene)hydrazine","C514579","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"20499133","Pharmacokinetics and derivation of an anticancer dosing regimen for PAC-1, a preferential small molecule activator of procaspase-3, in healthy dogs.","20499133",136]
["(4-benzylpiperazin-1-yl)acetic acid (3-allyl-2-hydroxybenzylidene)hydrazine","(4-benzylpiperazin-1-yl)acetic acid (3-allyl-2-hydroxybenzylidene)hydrazine","C514579","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"20638399","Procaspase-activating compound 1 induces a caspase-3-dependent cell death in cerebellar granule neurons.","20638399",136]
["(4-benzylpiperazin-1-yl)acetic acid (3-allyl-2-hydroxybenzylidene)hydrazine","(4-benzylpiperazin-1-yl)acetic acid (3-allyl-2-hydroxybenzylidene)hydrazine","C514579","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"20823163","Discovery and canine preclinical assessment of a nontoxic procaspase-3-activating compound.","20823163",136]
["(4-benzylpiperazin-1-yl)acetic acid (3-allyl-2-hydroxybenzylidene)hydrazine","(4-benzylpiperazin-1-yl)acetic acid (3-allyl-2-hydroxybenzylidene)hydrazine","C514579","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"21893038","Cell death induced by novel procaspase-3 activators can be reduced by growth factors.","21893038",136]
["(4-benzylpiperazin-1-yl)acetic acid (3-allyl-2-hydroxybenzylidene)hydrazine","(4-benzylpiperazin-1-yl)acetic acid (3-allyl-2-hydroxybenzylidene)hydrazine","C514579","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22007686","Parallel synthesis and biological evaluation of 837 analogues of procaspase-activating compound 1 (PAC-1).","22007686",136]
["(4-benzylpiperazin-1-yl)acetic acid (3-allyl-2-hydroxybenzylidene)hydrazine","(4-benzylpiperazin-1-yl)acetic acid (3-allyl-2-hydroxybenzylidene)hydrazine","C514579","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23859779","Synthesis and initial in vitro biological evaluation of two new zinc-chelating compounds: comparison with TPEN and PAC-1.","23859779",136]
["(4-benzylpiperazin-1-yl)acetic acid (3-allyl-2-hydroxybenzylidene)hydrazine","(4-benzylpiperazin-1-yl)acetic acid (3-allyl-2-hydroxybenzylidene)hydrazine","C514579","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24383395","Dual small-molecule targeting of procaspase-3 dramatically enhances zymogen activation and anticancer activity.","24383395",136]
["(4-benzylpiperazin-1-yl)acetic acid (3-allyl-2-hydroxybenzylidene)hydrazine","(4-benzylpiperazin-1-yl)acetic acid (3-allyl-2-hydroxybenzylidene)hydrazine","C514579","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25498514","Antitumor activity of paclitaxel is significantly enhanced by a novel proapoptotic agent in non-small cell lung cancer.","25498514",136]
["(4-benzylpiperazin-1-yl)acetic acid (3-allyl-2-hydroxybenzylidene)hydrazine","(4-benzylpiperazin-1-yl)acetic acid (3-allyl-2-hydroxybenzylidene)hydrazine","C514579","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25754465","Targeting procaspase-3 with WF-208, a novel PAC-1 derivative, causes selective cancer cell apoptosis.","25754465",136]
["(4-benzylpiperazin-1-yl)acetic acid (3-allyl-2-hydroxybenzylidene)hydrazine","(4-benzylpiperazin-1-yl)acetic acid (3-allyl-2-hydroxybenzylidene)hydrazine","C514579","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25856364","Removal of Metabolic Liabilities Enables Development of Derivatives of Procaspase-Activating Compound 1 (PAC-1) with Improved Pharmacokinetics.","25856364",136]
["(4-benzylpiperazin-1-yl)acetic acid (3-allyl-2-hydroxybenzylidene)hydrazine","(4-benzylpiperazin-1-yl)acetic acid (3-allyl-2-hydroxybenzylidene)hydrazine","C514579","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"26620316","Synergistic antitumor activity of pro-apoptotic agent PAC-1 with cisplatinum by the activation of CASP3 in pulmonary adenocarcinoma cell line H1299.","26620316",136]
["(4-benzylpiperazin-1-yl)acetic acid (3-allyl-2-hydroxybenzylidene)hydrazine","(4-benzylpiperazin-1-yl)acetic acid (3-allyl-2-hydroxybenzylidene)hydrazine","C514579","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27488460","SM-1, a novel PAC-1 derivative, activates procaspase-3 and causes cancer cell apoptosis.","27488460",136]
["(4-benzylpiperazin-1-yl)acetic acid (3-allyl-2-hydroxybenzylidene)hydrazine","(4-benzylpiperazin-1-yl)acetic acid (3-allyl-2-hydroxybenzylidene)hydrazine","C514579","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2006,"16936720","Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy.","16936720",136]
["(4-benzylpiperazin-1-yl)acetic acid (3-allyl-2-hydroxybenzylidene)hydrazine","(4-benzylpiperazin-1-yl)acetic acid (3-allyl-2-hydroxybenzylidene)hydrazine","C514579","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24383395","Dual small-molecule targeting of procaspase-3 dramatically enhances zymogen activation and anticancer activity.","24383395",136]
["(4-benzylpiperazin-1-yl)acetic acid (3-allyl-2-hydroxybenzylidene)hydrazine","(4-benzylpiperazin-1-yl)acetic acid (3-allyl-2-hydroxybenzylidene)hydrazine","C514579","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25754465","Targeting procaspase-3 with WF-208, a novel PAC-1 derivative, causes selective cancer cell apoptosis.","25754465",136]
["(4-benzylpiperazin-1-yl)acetic acid (3-allyl-2-hydroxybenzylidene)hydrazine","(4-benzylpiperazin-1-yl)acetic acid (3-allyl-2-hydroxybenzylidene)hydrazine","C514579","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2009,"19135329","Development of a high performance liquid chromatography method for quantification of PAC-1 in rat plasma.","19135329",136]
["(4-benzylpiperazin-1-yl)acetic acid (3-allyl-2-hydroxybenzylidene)hydrazine","(4-benzylpiperazin-1-yl)acetic acid (3-allyl-2-hydroxybenzylidene)hydrazine","C514579","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2010,"19889506","Isolation and structure elucidation of degradation products in the potential anticancer drug PAC-1.","19889506",136]
["(4-bromophenyl)(4-(3,4,5-trimethoxyphenyl)-1H-pyrrol-3-yl)methanone","(4-bromophenyl)(4-(3,4,5-trimethoxyphenyl)-1H-pyrrol-3-yl)methanone","C000614476","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"27696660","Synthesis and Anticancer Activity of 3-(Substituted Aroyl)-4-(3,4,5-trimethoxyphenyl)-1H-pyrrole Derivatives.","27696660",136]
["(4-bromophenyl)-3-(4-((6-(2-morpholin-4-ylethoxy)benzothiazol-2-ylamino)methyl)phenyl)urea","(4-bromophenyl)-3-(4-((6-(2-morpholin-4-ylethoxy)benzothiazol-2-ylamino)methyl)phenyl)urea","C000622737","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28529042","Optimization and biological evaluation of 2-aminobenzothiazole derivatives as Aurora B kinase inhibitors.","28529042",136]
["(4-chlorophenyl)-9H-indeno(2,1-d)pyrimidine-2,4-diamine","(4-chlorophenyl)-9H-indeno(2,1-d)pyrimidine-2,4-diamine","C575841","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22739090","Novel tricyclic indeno[2,1-d]pyrimidines with dual antiangiogenic and cytotoxic activities as potent antitumor agents.","22739090",136]
["(4-fluorophenyl)((5-(5-(5-fluoropyridin-2-yl)-1,2,4-oxadiazol-3-yl)-2-methylpiperidin-1-yl)methanone","(4-fluorophenyl)((5-(5-(5-fluoropyridin-2-yl)-1,2,4-oxadiazol-3-yl)-2-methylpiperidin-1-yl)methanone","C000594260","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2014,"23291536","Mechanism based neurotoxicity of mGlu5 positive allosteric modulators--development challenges for a promising novel antipsychotic target.","23291536",136]
["(4-hydroxy-3-nitrocoumarin)bis(phenanthroline)silver(I)","(4-hydroxy-3-nitrocoumarin)bis(phenanthroline)silver(I)","C539395","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2009,"19041861","Role of cell cycle events and apoptosis in mediating the anti-cancer activity of a silver(I) complex of 4-hydroxy-3-nitro-coumarin-bis(phenanthroline) in human malignant cancer cells.","19041861",136]
["(4-hydroxy-3-nitrocoumarin)bis(phenanthroline)silver(I)","(4-hydroxy-3-nitrocoumarin)bis(phenanthroline)silver(I)","C539395","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"19041861","Role of cell cycle events and apoptosis in mediating the anti-cancer activity of a silver(I) complex of 4-hydroxy-3-nitro-coumarin-bis(phenanthroline) in human malignant cancer cells.","19041861",136]
["(4-iodobutyl)triphenylphosphonium","(4-iodobutyl)triphenylphosphonium","C456341","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2002,"11861642","Specific modification of mitochondrial protein thiols in response to oxidative stress: a proteomics approach.","11861642",136]
["(4-methoxyphenyl)(3,4,5-trimethoxyphenyl)methanone","(4-methoxyphenyl)(3,4,5-trimethoxyphenyl)methanone","C560639","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23756174","(4-Methoxyphenyl)(3,4,5-trimethoxyphenyl)methanone inhibits tubulin polymerization, induces G2/M arrest, and triggers apoptosis in human leukemia HL-60 cells.","23756174",136]
["(4-methoxyphenyl)(3,4,5-trimethoxyphenyl)methanone","(4-methoxyphenyl)(3,4,5-trimethoxyphenyl)methanone","C560639","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21875663","Assessment of genotoxic effects of (4-methoxyphenyl)(3,4,5-trimethoxyphenyl)methanone in human lymphocytes.","21875663",136]
["(4-oxo-3,4-dihydroquinazolin-2-yl)methyl 4-methoxybenzylcarbamodithioate","(4-oxo-3,4-dihydroquinazolin-2-yl)methyl 4-methoxybenzylcarbamodithioate","C000611423","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"26703795","Synthesis and biological evaluation of quinazolin-4(3H)-one derivatives bearing dithiocarbamate side chain at C2-position as potential antitumor agents.","26703795",136]
["(4R)-5,10-seco-19-norpregna-4,5-diene-3,10,20-trione","(4R)-5,10-seco-19-norpregna-4,5-diene-3,10,20-trione","C015501","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1986,"3702462","The effects of diethyl-4-methyl-3-oxo-4-aza-5 alpha-androstane-17 beta-carboxamide (4-MA) and (4R)-5,10-SECO-19-norpregna-4,5-diene-3,10,20-trione (SECO) on androgen biosynthesis in the rat testis and epididymis.","3702462",136]
["(4-serotonyl)-4-serotonin","(4-serotonyl)-4-serotonin","C115055","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1997,"9466949","Oxidation, nitrosation, and nitration of serotonin by nitric oxide-derived nitrogen oxides: biological implications in the rat vascular system.","9466949",136]
["(4SR,5SR)-4-(hydroxymethyl)-3-methylene-5-octyldihydrofuran-2(3H)-one","(4SR,5SR)-4-(hydroxymethyl)-3-methylene-5-octyldihydrofuran-2(3H)-one","C000618473","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28324785","(-)-UB006: A new fatty acid synthase inhibitor and cytotoxic agent without anorexic side effects.","28324785",136]
["(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","C546624","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"21803746","Combinatorial treatments that overcome PDGFRβ-driven resistance of melanoma cells to V600EB-RAF inhibition.","21803746",136]
["(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","C546624","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22143671","The dual mTORC1 and mTORC2 inhibitor AZD8055 has anti-tumor activity in acute myeloid leukemia.","22143671",136]
["(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","C546624","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22271687","Enhanced apoptosis and tumor growth suppression elicited by combination of MEK (selumetinib) and mTOR kinase inhibitors (AZD8055).","22271687",136]
["(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","C546624","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"24133218","Pan-mammalian target of rapamycin (mTOR) inhibitor AZD8055 primes rhabdomyosarcoma cells for ABT-737-induced apoptosis by down-regulating Mcl-1 protein.","24133218",136]
["(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","C546624","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24233399","Synergistic activities of MET/RON inhibitor BMS-777607 and mTOR inhibitor AZD8055 to polyploid cells derived from pancreatic cancer and cancer stem cells.","24233399",136]
["(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","C546624","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24297300","AZD8055 induces cell death associated with autophagy and activation of AMPK in hepatocellular carcinoma.","24297300",136]
["(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","C546624","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2014,"24706460","HSP90 inhibitor AUY922 abrogates up-regulation of RTKs by mTOR inhibitor AZD8055 and potentiates its antiproliferative activity in human breast cancer.","24706460",136]
["(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","C546624","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24739393","Evaluation of apoptosis induction by concomitant inhibition of MEK, mTOR, and Bcl-2 in human acute myelogenous leukemia cells.","24739393",136]
["(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","C546624","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"25172964","Delineating the mTOR kinase pathway using a dual TORC1/2 inhibitor, AZD8055, in multiple myeloma.","25172964",136]
["(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","C546624","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"26897748","C6 ceramide sensitizes the anti-hepatocellular carcinoma (HCC) activity by AZD-8055, a novel mTORC1/2 dual inhibitor.","26897748",136]
["(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","C546624","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27423593","Inhibition of mammalian target of rapamycin attenuates early brain injury through modulating microglial polarization after experimental subarachnoid hemorrhage in rats.","27423593",136]
["(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","C546624","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27461218","Pro-survival responses to the dual inhibition of anti-apoptotic Bcl-2 family proteins and mTOR-mediated signaling in hypoxic colorectal carcinoma cells.","27461218",136]
["(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","C546624","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"27980105","The mTORC1/2 Inhibitor AZD8055 Strengthens the Efficiency of the MEK Inhibitor Trametinib to Reduce the Mcl-1/[Bim and Puma] ratio and to Sensitize Ovarian Carcinoma Cells to ABT-737.","27980105",136]
["(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","C546624","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2018,"29491070","AZD8055 Exerts Antitumor Effects on Colon Cancer Cells by Inhibiting mTOR and Cell-cycle Progression.","29491070",136]
["(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","C546624","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20028854","AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity.","20028854",136]
["(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","C546624","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"21337679","Initial testing (stage 1) of the mTOR kinase inhibitor AZD8055 by the pediatric preclinical testing program.","21337679",136]
["(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","C546624","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22143671","The dual mTORC1 and mTORC2 inhibitor AZD8055 has anti-tumor activity in acute myeloid leukemia.","22143671",136]
["(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","C546624","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24297300","AZD8055 induces cell death associated with autophagy and activation of AMPK in hepatocellular carcinoma.","24297300",136]
["(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","C546624","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24457069","Impact of dual mTORC1/2 mTOR kinase inhibitor AZD8055 on acquired endocrine resistance in breast cancer in vitro.","24457069",136]
["(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","C546624","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2014,"24706460","HSP90 inhibitor AUY922 abrogates up-regulation of RTKs by mTOR inhibitor AZD8055 and potentiates its antiproliferative activity in human breast cancer.","24706460",136]
["(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","C546624","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24739393","Evaluation of apoptosis induction by concomitant inhibition of MEK, mTOR, and Bcl-2 in human acute myelogenous leukemia cells.","24739393",136]
["(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","C546624","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"25172964","Delineating the mTOR kinase pathway using a dual TORC1/2 inhibitor, AZD8055, in multiple myeloma.","25172964",136]
["(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","C546624","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"25307040","Adenosine triphosphate-competitive mTOR inhibitors: a new class of immunosuppressive agents that inhibit allograft rejection.","25307040",136]
["(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","C546624","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"26840085","Dual mTORC1/2 inhibition induces anti-proliferative effect in NF1-associated plexiform neurofibroma and malignant peripheral nerve sheath tumor cells.","26840085",136]
["(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","C546624","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"26851731","Reversal of phenotypes of cellular senescence by pan-mTOR inhibition.","26851731",136]
["(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","C546624","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27128484","mTOR Inhibition Attenuates Dextran Sulfate Sodium-Induced Colitis by Suppressing T Cell Proliferation and Balancing TH1/TH17/Treg Profile.","27128484",136]
["(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","C546624","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"27980105","The mTORC1/2 Inhibitor AZD8055 Strengthens the Efficiency of the MEK Inhibitor Trametinib to Reduce the Mcl-1/[Bim and Puma] ratio and to Sensitize Ovarian Carcinoma Cells to ABT-737.","27980105",136]
["(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","C546624","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2018,"29491070","AZD8055 Exerts Antitumor Effects on Colon Cancer Cells by Inhibiting mTOR and Cell-cycle Progression.","29491070",136]
["(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol","C546624","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2016,"27423593","Inhibition of mammalian target of rapamycin attenuates early brain injury through modulating microglial polarization after experimental subarachnoid hemorrhage in rats.","27423593",136]
["(5-(2-methoxy-5-chloro-5-phenyl)furan-2-ylcarbonyl)guanidine","(5-(2-methoxy-5-chloro-5-phenyl)furan-2-ylcarbonyl)guanidine","C502305","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2005,"15792786","Effects of KR-32570, a new Na+/H+ exchanger inhibitor, on functional and metabolic impairments produced by global ischemia and reperfusion in the perfused rat heart.","15792786",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C515,B515)","v":"(5(4),10(4),15(4),20(4)-tetra-tert-butyl-5(2),5(6),15(2),15(6)-tetrakis(2,2-bis(carboxylato)ethyl)-5,10,15,20-tetraphenylporphyrin)iron(III)"},"(5(4),10(4),15(4),20(4)-tetra-tert-butyl-5(2),5(6),15(2),15(6)-tetrakis(2,2-bis(carboxylato)ethyl)-5,10,15,20-tetraphenylporphyrin)iron(III)","C545844","1_MIE",867,1,"Intracellular pH","Decrease",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J515,K515)","v":"Hydrogen-Ion Concentration"},"D006863","Hydrogen-Ion Concentration",2,2,2009,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q515,Q515)","v":"19601585"},"Mechanistic investigations of the reaction of an iron(III) octa-anionic porphyrin complex with hydrogen peroxide and the catalyzed oxidation of diammonium-2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonate).","19601585",136]
["(5,10,15,20-tetrakis(N-(benzyl-4'-carboxylate)-2-pyridinium)-21H,23H-porphine)iron(III)","(5,10,15,20-tetrakis(N-(benzyl-4'-carboxylate)-2-pyridinium)-21H,23H-porphine)iron(III)","C539253","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2009,"19033557","INO-4885 [5,10,15,20-tetra[N-(benzyl-4'-carboxylate)-2-pyridinium]-21H,23H-porphine iron(III) chloride], a peroxynitrite decomposition catalyst, protects the heart against reperfusion injury in mice.","19033557",136]
["(5,6-dimethyl-1,10-phenanthroline)(1,2-diaminocyclohexane)platinum(II)","(5,6-dimethyl-1,10-phenanthroline)(1,2-diaminocyclohexane)platinum(II)","C529817","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2008,"18412325","Degradation of bidentate-coordinated platinum(II)-based DNA intercalators by reduced L-glutathione.","18412325",136]
["(5,6-dimethyl-1,10-phenanthroline)(ethylenediamine)platinum(II)","(5,6-dimethyl-1,10-phenanthroline)(ethylenediamine)platinum(II)","C529819","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2008,"18412325","Degradation of bidentate-coordinated platinum(II)-based DNA intercalators by reduced L-glutathione.","18412325",136]
["(5-amino-3-methyl-6-methoxybenzo(b)furan-2-yl)(3,4,5-trimethoxyphenyl) methanone","(5-amino-3-methyl-6-methoxybenzo(b)furan-2-yl)(3,4,5-trimethoxyphenyl) methanone","C569481","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"21805646","Synthesis and antitumor molecular mechanism of agents based on amino 2-(3',4',5'-trimethoxybenzoyl)benzo[b]furan: inhibition of tubulin and induction of apoptosis.","21805646",136]
["(5aR)-5a-C-pentyl-4-epi-isofagomine","(5aR)-5a-C-pentyl-4-epi-isofagomine","C000614378","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2017,"27750150","(5aR)-5a-C-Pentyl-4-epi-isofagomine: A powerful inhibitor of lysosomal β-galactosidase and a remarkable chaperone for mutations associated with GM1-gangliosidosis and Morquio disease type B.","27750150",136]
["(5-chloro-N-(1,1-dioxo-1H-1lamda(6)-benzo(b)thiophen-6-yl)-2-hydroxybenzamide","(5-chloro-N-(1,1-dioxo-1H-1lamda(6)-benzo(b)thiophen-6-yl)-2-hydroxybenzamide","C000595831","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24904966","Discovery of potent anticancer agent HJC0416, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3).","24904966",136]
["(5-fluoro-2-methyl-1-(3,5-dimethoxy-4-hydroxybenzylidene)-3-(N-benzyl)indene)acetamide","(5-fluoro-2-methyl-1-(3,5-dimethoxy-4-hydroxybenzylidene)-3-(N-benzyl)indene)acetamide","C508487","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2006,"16432163","The sulindac derivatives OSI-461, OSIP486823, and OSIP487703 arrest colon cancer cells in mitosis by causing microtubule depolymerization.","16432163",136]
["(5-fluoro-2-methyl-1-(3,5-dimethoxy-4-hydroxybenzylidene)-3-(N-benzyl)indene)acetamide","(5-fluoro-2-methyl-1-(3,5-dimethoxy-4-hydroxybenzylidene)-3-(N-benzyl)indene)acetamide","C508487","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2006,"16432163","The sulindac derivatives OSI-461, OSIP486823, and OSIP487703 arrest colon cancer cells in mitosis by causing microtubule depolymerization.","16432163",136]
["(5-fluoro-2-methyl-1-(4-pyridyl)methylene-3-(N-benzyl)-indene)-acetamide hydrochloride","(5-fluoro-2-methyl-1-(4-pyridyl)methylene-3-(N-benzyl)-indene)-acetamide hydrochloride","C439285","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2002,"12492113","Vasodilator-stimulated phosphoprotein (VASP) phosphorylation provides a biomarker for the action of exisulind and related agents that activate protein kinase G.","12492113",136]
["(5-fluoro-2-methyl-1-(4-pyridyl)methylene-3-(N-benzyl)-indene)-acetamide hydrochloride","(5-fluoro-2-methyl-1-(4-pyridyl)methylene-3-(N-benzyl)-indene)-acetamide hydrochloride","C439285","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2001,"11602670","Cyclic GMP-dependent protein kinase activation and induction by exisulind and CP461 in colon tumor cells.","11602670",136]
["(5-fluoro-2-methyl-1-(4-pyridyl)methylene-3-(N-benzyl)-indene)-acetamide hydrochloride","(5-fluoro-2-methyl-1-(4-pyridyl)methylene-3-(N-benzyl)-indene)-acetamide hydrochloride","C439285","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2002,"12384529","Benzylamide sulindac analogues induce changes in cell shape, loss of microtubules and G(2)-M arrest in a chronic lymphocytic leukemia (CLL) cell line and apoptosis in primary CLL cells.","12384529",136]
["(5-fluoro-2-methyl-1-(4-pyridyl)methylene-3-(N-benzyl)-indene)-acetamide hydrochloride","(5-fluoro-2-methyl-1-(4-pyridyl)methylene-3-(N-benzyl)-indene)-acetamide hydrochloride","C439285","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2002,"12392815","Pro-apoptotic actions of exisulind and CP461 in SW480 colon tumor cells involve beta-catenin and cyclin D1 down-regulation.","12392815",136]
["(5-fluoro-2-methyl-1-(4-pyridyl)methylene-3-(N-benzyl)-indene)-acetamide hydrochloride","(5-fluoro-2-methyl-1-(4-pyridyl)methylene-3-(N-benzyl)-indene)-acetamide hydrochloride","C439285","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2002,"12477052","CP248, a derivative of exisulind, causes growth inhibition, mitotic arrest, and abnormalities in microtubule polymerization in glioma cells.","12477052",136]
["(5-fluoro-2-methyl-1-(4-pyridyl)methylene-3-(N-benzyl)-indene)-acetamide hydrochloride","(5-fluoro-2-methyl-1-(4-pyridyl)methylene-3-(N-benzyl)-indene)-acetamide hydrochloride","C439285","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2006,"16432163","The sulindac derivatives OSI-461, OSIP486823, and OSIP487703 arrest colon cancer cells in mitosis by causing microtubule depolymerization.","16432163",136]
["(5-fluoro-2-methyl-1-(4-pyridyl)methylene-3-(N-benzyl)-indene)-acetamide hydrochloride","(5-fluoro-2-methyl-1-(4-pyridyl)methylene-3-(N-benzyl)-indene)-acetamide hydrochloride","C439285","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2009,"18509645","A dose-ranging study of the pharmacokinetics and pharmacodynamics of the selective apoptotic antineoplastic drug (SAAND), OSI-461, in patients with advanced cancer, in the fasted and fed state.","18509645",136]
["(5-fluoro-2-methyl-1-(4-pyridyl)methylene-3-(N-benzyl)-indene)-acetamide hydrochloride","(5-fluoro-2-methyl-1-(4-pyridyl)methylene-3-(N-benzyl)-indene)-acetamide hydrochloride","C439285","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"21717102","The novel compound OSI-461 induces apoptosis and growth arrest in human acute myeloid leukemia cells.","21717102",136]
["(5-fluoro-2-methyl-1-(4-pyridyl)methylene-3-(N-benzyl)-indene)-acetamide hydrochloride","(5-fluoro-2-methyl-1-(4-pyridyl)methylene-3-(N-benzyl)-indene)-acetamide hydrochloride","C439285","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2006,"16432163","The sulindac derivatives OSI-461, OSIP486823, and OSIP487703 arrest colon cancer cells in mitosis by causing microtubule depolymerization.","16432163",136]
["(5-fluoro-2-methyl-3-quinolin-2-ylmethylindo-1-yl)acetic acid","(5-fluoro-2-methyl-3-quinolin-2-ylmethylindo-1-yl)acetic acid","C571151","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22106101","Pharmacologic profile of OC000459, a potent, selective, and orally active D prostanoid receptor 2 antagonist that inhibits mast cell-dependent activation of T helper 2 lymphocytes and eosinophils.","22106101",136]
["(5-methyl-1,10-phenanthroline)(1,2-diaminocyclohexane)platinum(II)","(5-methyl-1,10-phenanthroline)(1,2-diaminocyclohexane)platinum(II)","C529818","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2008,"18412325","Degradation of bidentate-coordinated platinum(II)-based DNA intercalators by reduced L-glutathione.","18412325",136]
["(5-tert-butyl-2-hydroxyisophthalaldehyde-bis-2-pyridinehydrazone)Zn(II)","(5-tert-butyl-2-hydroxyisophthalaldehyde-bis-2-pyridinehydrazone)Zn(II)","C584230","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2013,"23601283","A \"turn-on\" fluorescent chemosensor for zinc ion with facile synthesis and application in live cell imaging.","23601283",136]
["(5Z)-7-((1R,2R, 3R,5S)-2-((1E)-3,3-difluoro-4-phenoxy -1-butenyl)-3,5-dihydroxycyclopentyl)-5-heptenoic acid","(5Z)-7-((1R,2R, 3R,5S)-2-((1E)-3,3-difluoro-4-phenoxy -1-butenyl)-3,5-dihydroxycyclopentyl)-5-heptenoic acid","C485334","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22910791","Effects of AFP-172 on COX-2-induced angiogenic activities on human umbilical vein endothelial cells.","22910791",136]
["(6-(3-chloro-4-fluoro-benzyl)-4-hydroxy-2-methyl-3,5-dioxo-2,3,5,6,7,8-hexahydro-(2,6)naphthyridine-1-carboxylic acid dimethylamide)","(6-(3-chloro-4-fluoro-benzyl)-4-hydroxy-2-methyl-3,5-dioxo-2,3,5,6,7,8-hexahydro-(2,6)naphthyridine-1-carboxylic acid dimethylamide)","C538972","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2008,"18819851","Serendipitous discovery of a pH-dependant atropisomer bond rotation: toward a write-protectable chiral molecular switch?","18819851",136]
["(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine","(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine","C516138","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2009,"19428322","AMP-activated protein kinase-dependent and -independent mechanisms underlying in vitro antiglioma action of compound C.","19428322",136]
["(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine","(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine","C516138","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2009,"19528633","AMPK inhibitor Compound C stimulates ceramide production and promotes Bax redistribution and apoptosis in MCF7 breast carcinoma cells.","19528633",136]
["(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine","(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine","C516138","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"20451517","Compound C sensitizes Caki renal cancer cells to TRAIL-induced apoptosis through reactive oxygen species-mediated down-regulation of c-FLIPL and Mcl-1.","20451517",136]
["(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine","(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine","C516138","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2011,"21243583","Inhibition of AMPK-associated autophagy enhances caffeic acid phenethyl ester-induced cell death in C6 glioma cells.","21243583",136]
["(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine","(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine","C516138","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22415077","Effect of the AMP-kinase modulators AICAR, metformin and compound C on insulin secretion of INS-1E rat insulinoma cells under standard cell culture conditions.","22415077",136]
["(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine","(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine","C516138","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22674626","AMPK inhibitor compound C suppresses cell proliferation by induction of apoptosis and autophagy in human colorectal cancer cells.","22674626",136]
["(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine","(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine","C516138","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23228943","AMPK inhibition enhances apoptosis in MLL-rearranged pediatric B-acute lymphoblastic leukemia cells.","23228943",136]
["(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine","(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine","C516138","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23274516","p53 modulates the AMPK inhibitor compound C induced apoptosis in human skin cancer cells.","23274516",136]
["(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine","(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine","C516138","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"24157877","Implication of transcriptional repression in compound C-induced apoptosis in cancer cells.","24157877",136]
["(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine","(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine","C516138","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24419061","The AMPK inhibitor compound C is a potent AMPK-independent antiglioma agent.","24419061",136]
["(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine","(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine","C516138","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25227893","Differential cellular responses induced by dorsomorphin and LDN-193189 in chemotherapy-sensitive and chemotherapy-resistant human epithelial ovarian cancer cells.","25227893",136]
["(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine","(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine","C516138","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2008,"18721791","Compound C inhibits clonal expansion of preadipocytes by increasing p21 level irrespectively of AMPK inhibition.","18721791",136]
["(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine","(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine","C516138","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"19528633","AMPK inhibitor Compound C stimulates ceramide production and promotes Bax redistribution and apoptosis in MCF7 breast carcinoma cells.","19528633",136]
["(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine","(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine","C516138","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20451517","Compound C sensitizes Caki renal cancer cells to TRAIL-induced apoptosis through reactive oxygen species-mediated down-regulation of c-FLIPL and Mcl-1.","20451517",136]
["(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine","(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine","C516138","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21384475","Dorsomorphin promotes human embryonic stem cell self-renewal.","21384475",136]
["(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine","(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine","C516138","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21566210","Compound C inhibits vascular smooth muscle cell proliferation and migration in an AMP-activated protein kinase-independent fashion.","21566210",136]
["(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine","(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine","C516138","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22415077","Effect of the AMP-kinase modulators AICAR, metformin and compound C on insulin secretion of INS-1E rat insulinoma cells under standard cell culture conditions.","22415077",136]
["(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine","(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine","C516138","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22674626","AMPK inhibitor compound C suppresses cell proliferation by induction of apoptosis and autophagy in human colorectal cancer cells.","22674626",136]
["(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine","(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine","C516138","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24419061","The AMPK inhibitor compound C is a potent AMPK-independent antiglioma agent.","24419061",136]
["(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine","(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine","C516138","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2015,"25227893","Differential cellular responses induced by dorsomorphin and LDN-193189 in chemotherapy-sensitive and chemotherapy-resistant human epithelial ovarian cancer cells.","25227893",136]
["(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine","(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine","C516138","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"25663289","The BMP signaling pathway leads to enhanced proliferation in serous ovarian cancer-A potential therapeutic target.","25663289",136]
["(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine","(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine","C516138","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"26522925","Compound C inhibits in vitro angiogenesis and ameliorates thrombin-induced endothelial barrier failure.","26522925",136]
["(6-(thiophen-2-yl)-3-(3,4,5-trimethoxyphenyl)-6,7-dihydro-5H-(1,2,4)triazolo(3,4-b)(1,3,4)thiadiazin-7-yl)(p-tolyl)methanone","(6-(thiophen-2-yl)-3-(3,4,5-trimethoxyphenyl)-6,7-dihydro-5H-(1,2,4)triazolo(3,4-b)(1,3,4)thiadiazin-7-yl)(p-tolyl)methanone","C000607136","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"26363869","Design, synthesis and biological evaluation of novel 1,2,4-triazolo [3,4-b][1,3,4] thiadiazines bearing furan and thiophene nucleus.","26363869",136]
["(6,7-dimethoxy-2,4-dihydroindeno(1,2-c)pyrazol-3-yl)(3-fluorophenyl)amine","(6,7-dimethoxy-2,4-dihydroindeno(1,2-c)pyrazol-3-yl)(3-fluorophenyl)amine","C505208","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"17178444","Parallel screening approach to identify solubility-enhancing formulations for improved bioavailability of a poorly water-soluble compound using milligram quantities of material.","17178444",136]
["(6,7-dimethoxyquinolin-4-yl)(5-methoxy-2,2-dimethyl-2H-chromen-6-yl)methyl acetate","(6,7-dimethoxyquinolin-4-yl)(5-methoxy-2,2-dimethyl-2H-chromen-6-yl)methyl acetate","C000601052","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25976766","Synthesis and Evaluation of a Novel Deguelin Derivative, L80, which Disrupts ATP Binding to the C-terminal Domain of Heat Shock Protein 90.","25976766",136]
["(68Ga)Glu-urea-Lys(Ahx)-HBED-CC","(68Ga)Glu-urea-Lys(Ahx)-HBED-CC","C000604952","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2015,"26287143","Development of a Single Vial Kit Solution for Radiolabeling of 68Ga-DKFZ-PSMA-11 and Its Performance in Prostate Cancer Patients.","26287143",136]
["(6-amino-1-methyl-5-nitrosouracilato-N3)triphenylphosphinegold(I)","(6-amino-1-methyl-5-nitrosouracilato-N3)triphenylphosphinegold(I)","C584133","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23644209","A potential antitumor agent, (6-amino-1-methyl-5-nitrosouracilato-N3)-triphenylphosphine-gold(I): structural studies and in vivo biological effects against experimental glioma.","23644209",136]
["(6E,10E)isopolycerasoidol","(6E,10E)isopolycerasoidol","C000606813","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25946039","(6E,10E) Isopolycerasoidol and (6E,10E) Isopolycerasoidol Methyl Ester, Prenylated Benzopyran Derivatives from Pseuduvaria monticola Induce Mitochondrial-Mediated Apoptosis in Human Breast Adenocarcinoma Cells.","25946039",136]
["(6E,10E)isopolycerasoidol methyl ester","(6E,10E)isopolycerasoidol methyl ester","C000606814","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25946039","(6E,10E) Isopolycerasoidol and (6E,10E) Isopolycerasoidol Methyl Ester, Prenylated Benzopyran Derivatives from Pseuduvaria monticola Induce Mitochondrial-Mediated Apoptosis in Human Breast Adenocarcinoma Cells.","25946039",136]
["(7.7)paracyclophane","(7.7)paracyclophane","C544518","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2009,"19707682","Syntheses of naturally occurring cytotoxic [7.7]paracyclophanes, (-)-cylindrocyclophane A and its enantiomer, and implications for biological activity.","19707682",136]
["(7-diethylaminocoumarin-4-yl)methyl phosphate","(7-diethylaminocoumarin-4-yl)methyl phosphate","C556999","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2010,"21087059","pH effect on the photochemistry of 4-methylcoumarin phosphate esters: caged-phosphate case study.","21087059",136]
["(7-hydroxy-4-methylcoumarin)cerium(III)","(7-hydroxy-4-methylcoumarin)cerium(III)","C493506","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2004,"15050043","Stability of the complexes of some lanthanides with coumarin derivatives. I. Cerium(III)-4-methyl-7-hydroxycoumarin.","15050043",136]
["(7''R)-8-(1-(4'-hydroxy-3'-methoxyphenyl)prop-2-en-1-yl)chrysin","(7''R)-8-(1-(4'-hydroxy-3'-methoxyphenyl)prop-2-en-1-yl)chrysin","C549661","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2010,"20307087","Study on the constituents of Mexican propolis and their cytotoxic activity against PANC-1 human pancreatic cancer cells.","20307087",136]
["(7''R)-8-(1-(4'-hydroxy-3'-methoxyphenyl)prop-2-en-1-yl)galangin","(7''R)-8-(1-(4'-hydroxy-3'-methoxyphenyl)prop-2-en-1-yl)galangin","C549660","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2010,"20307087","Study on the constituents of Mexican propolis and their cytotoxic activity against PANC-1 human pancreatic cancer cells.","20307087",136]
["(8R)-3beta,8-dihydroxypolypoda-13E,17E,21-triene","(8R)-3beta,8-dihydroxypolypoda-13E,17E,21-triene","C562122","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"21800858","(8R)-3β,8-dihydroxypolypoda-13E,17E,21-triene induces cell cycle arrest and apoptosis in treatment-resistant prostate cancer cells.","21800858",136]
["(8R,9S)-8,9-dihydro-6,9-epoxy-8,9-anhydropseudoerythromycin A","(8R,9S)-8,9-dihydro-6,9-epoxy-8,9-anhydropseudoerythromycin A","C560918","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Nasal Mucosa","D009297","Nasal Mucosa",1,2,2015,"25769240","Anti-inflammatory effects of a novel non-antibiotic macrolide, EM900, on mucus secretion of airway epithelium.","25769240",136]
["(90)Y-2,3-dicarboxypropane-1,1-diphosphonic acid","(90)Y-2,3-dicarboxypropane-1,1-diphosphonic acid","C528986","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2008,"18331797","Labeling, characterization, and in vivo localization of a new 90Y-based phosphonate chelate 2,3-dicarboxypropane-1,1-diphosphonic acid for the treatment of bone metastases: Comparison with 99mTc-DPD complex.","18331797",136]
["(all-E) phytoene","(all-E) phytoene","C100185","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2001,"11759292","Acyclic carotenoids and their oxidation mixtures inhibit the growth of HL-60 human promyelocytic leukemia cells.","11759292",136]
["(Au(d2pypp)(2))Cl","(Au(d2pypp)(2))Cl","C523596","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2007,"17697672","A gold(I) phosphine complex selectively induces apoptosis in breast cancer cells: implications for anticancer therapeutics targeted to mitochondria.","17697672",136]
["(Au(d2pypp)(2))Cl","(Au(d2pypp)(2))Cl","C523596","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2007,"17697672","A gold(I) phosphine complex selectively induces apoptosis in breast cancer cells: implications for anticancer therapeutics targeted to mitochondria.","17697672",136]
["(benzoxazol-2-ylmethyl)phosphonic acid","(benzoxazol-2-ylmethyl)phosphonic acid","C555445","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2010,"20863097","Synthesis and reactivity of (benzoxazol-2-ylmethyl)phosphonic acid.","20863097",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C579,B579)","v":"(bipyridine)(2-phenyl(5-fluoro)-imidazo(f)-1,10-phenathroline)ruthenium"},"(bipyridine)(2-phenyl(5-fluoro)-imidazo(f)-1,10-phenathroline)ruthenium","C465028","1_MIE",867,1,"Intracellular pH","Decrease",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J579,K579)","v":"Hydrogen-Ion Concentration"},"D006863","Hydrogen-Ion Concentration",2,2,2002,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q579,Q579)","v":"12137369"},"Fluorometric determination of DNA using a new ruthenium complex Ru(bpy)2PIP(V) as a nucleic acid probe.","12137369",136]
["(bipyridine)(morpholine dithiocarbamate)platinum(II)","(bipyridine)(morpholine dithiocarbamate)platinum(II)","C000589196","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25403161","Biological Evaluation of a New Synthesized Pt(II) Complex by Cytotoxic and Spectroscopic Studies.","25403161",136]
["(bipyridine)(morpholine dithiocarbamate)platinum(II)","(bipyridine)(morpholine dithiocarbamate)platinum(II)","C000589196","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2013,"24028849","Beta-casein and its complexes with chitosan as nanovehicles for delivery of a platinum anticancer drug.","24028849",136]
["(bis(3,5-dimethylpyrazol-1-yl)acetate)bis(tris(hydroxymethyl)phosphine)copper(I)","(bis(3,5-dimethylpyrazol-1-yl)acetate)bis(tris(hydroxymethyl)phosphine)copper(I)","C517226","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2006,"17149861","Synthesis, characterization, and in vitro antitumor properties of tris(hydroxymethyl)phosphine copper(I) complexes containing the new bis(1,2,4-triazol-1-yl)acetate ligand.","17149861",136]
["(bromodifluoromethyl)trimethylsilane","(bromodifluoromethyl)trimethylsilane","C000599115","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"25386787","Synthesis of gem-difluorinated nitroso compounds.","25386787",136]
["(bromoiso-valeryl)urea","(bromoiso-valeryl)urea","C119882","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1999,"10197421","Debromination of (alpha-bromoiso-valeryl)urea catalysed by rat blood.","10197421",136]
["(C(2)H(10)N(2))(5)(NH(4))(4)H(2)(Se(2)W(10)V(8)O(62)).9H(2)O","(C(2)H(10)N(2))(5)(NH(4))(4)H(2)(Se(2)W(10)V(8)O(62)).9H(2)O","C541881","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2009,"19443941","Antitumor effects of a selenium heteropoly complex in K562 cells.","19443941",136]
["(C(2)H(10)N(2))(5)(NH(4))(4)H(2)(Se(2)W(10)V(8)O(62)).9H(2)O","(C(2)H(10)N(2))(5)(NH(4))(4)H(2)(Se(2)W(10)V(8)O(62)).9H(2)O","C541881","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"19443941","Antitumor effects of a selenium heteropoly complex in K562 cells.","19443941",136]
["(Cd(C(6)H(6)O(7))(H(2)O))(n)","(Cd(C(6)H(6)O(7))(H(2)O))(n)","C478298","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2003,"12691558","Synthesis and spectroscopic and structural studies of a new cadmium(II)-citrate aqueous complex. Potential relevance to cadmium(II)-citrate speciation and links to cadmium toxicity.","12691558",136]
["(Co(2-hydroxyhippuric acid)(imidazol)(3)).H(2)O (2)","(Co(2-hydroxyhippuric acid)(imidazol)(3)).H(2)O (2)","C490238","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2004,"14729323","Model complexes with naturally occurring ligands (salicylglycine and imidazol) and the biometals copper and cobalt.","14729323",136]
["(copper2II(3,5-ditertiarybutylsalicylate)4(ethanol)4)","(copper2II(3,5-ditertiarybutylsalicylate)4(ethanol)4)","C515535","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2006,"16814979","Prevention of cisplatin-induced kidney epithelial cell apoptosis with a Cu superoxide dismutase-mimetic [copper2II(3,5-ditertiarybutylsalicylate)4(ethanol)4].","16814979",136]
["(Cr(salprn)(H2O)2)ClO4","(Cr(salprn)(H2O)2)ClO4","C417305","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2004,"15124906","Caspase-3: its potential involvement in Cr(III)-induced apoptosis of lymphocytes.","15124906",136]
["(Cu(4,4'-dimethyl-2,2'-bipyridine)(glycinato)(H2O))NO3","(Cu(4,4'-dimethyl-2,2'-bipyridine)(glycinato)(H2O))NO3","C586190","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23727332","Copper(II) mixed chelate compounds induce apoptosis through reactive oxygen species in neuroblastoma cell line CHP-212.","23727332",136]
["(Cu(4,7-dimethyl-1,10-phenanthroline)(acetylacetonato)(H2O))NO3","(Cu(4,7-dimethyl-1,10-phenanthroline)(acetylacetonato)(H2O))NO3","C586191","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23727332","Copper(II) mixed chelate compounds induce apoptosis through reactive oxygen species in neuroblastoma cell line CHP-212.","23727332",136]
["(Cu(4-methylcoumarin-6,7-dioxactetate)(phenanthroline)2)","(Cu(4-methylcoumarin-6,7-dioxactetate)(phenanthroline)2)","C523706","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2007,"17585902","Apoptotic cell death: a possible key event in mediating the in vitro anti-proliferative effect of a novel copper(II) complex, [Cu(4-Mecdoa)(phen)(2)] (phen=phenanthroline, 4-Mecdoa=4-methylcoumarin-6,7-dioxactetate), in human malignant cancer cells.","17585902",136]
["(Cu(4-methylcoumarin-6,7-dioxactetate)(phenanthroline)2)","(Cu(4-methylcoumarin-6,7-dioxactetate)(phenanthroline)2)","C523706","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2009,"19259707","DNA binding and oxidative DNA damage induced by a quercetin copper(II) complex: potential mechanism of its antitumor properties.","19259707",136]
["(Cu(4-methylcoumarin-6,7-dioxactetate)(phenanthroline)2)","(Cu(4-methylcoumarin-6,7-dioxactetate)(phenanthroline)2)","C523706","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2007,"17585902","Apoptotic cell death: a possible key event in mediating the in vitro anti-proliferative effect of a novel copper(II) complex, [Cu(4-Mecdoa)(phen)(2)] (phen=phenanthroline, 4-Mecdoa=4-methylcoumarin-6,7-dioxactetate), in human malignant cancer cells.","17585902",136]
["(Cu(4-methylcoumarin-6,7-dioxactetate)(phenanthroline)2)","(Cu(4-methylcoumarin-6,7-dioxactetate)(phenanthroline)2)","C523706","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"19758794","ROS-mediated autophagy was involved in cancer cell death induced by novel copper(II) complex.","19758794",136]
["(Cu(Imidazol)(4)Cl(2))(Cu(imidazole)(4)Cl)(2)(2-hydroxyhippuric acid)(2)","(Cu(Imidazol)(4)Cl(2))(Cu(imidazole)(4)Cl)(2)(2-hydroxyhippuric acid)(2)","C490236","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2004,"14729323","Model complexes with naturally occurring ligands (salicylglycine and imidazol) and the biometals copper and cobalt.","14729323",136]
["(Cu(Py-3')TPP-Ru(phen)2Cl)(PF6)","(Cu(Py-3')TPP-Ru(phen)2Cl)(PF6)","C547324","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2010,"19958751","DNA binding and photocleavage properties and apoptosis-inducing activities of a ruthenium porphyrin complex [(Py-3')TPP-Ru(phen)2Cl]Cl and its heterometallic derivatives.","19958751",136]
["(diaminocyclohexane)(demethylcantharidin)platinum(II)","(diaminocyclohexane)(demethylcantharidin)platinum(II)","C534069","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24476313","East-west fusion-necrosis and apoptosis acting in concert by demethylcantharidin-integrated platinum complexes.","24476313",136]
["(diaminocyclohexane)(demethylcantharidin)platinum(II)","(diaminocyclohexane)(demethylcantharidin)platinum(II)","C534069","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2014,"24476313","East-west fusion-necrosis and apoptosis acting in concert by demethylcantharidin-integrated platinum complexes.","24476313",136]
["(diaminocyclohexane)(diacetato)(dichloro)platinum","(diaminocyclohexane)(diacetato)(dichloro)platinum","C119451","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2001,"11705886","Bimodal effects of 1R,2R-diaminocyclohexane(trans-diacetato)(dichloro)platinum(IV) on cell cycle checkpoints.","11705886",136]
["(diaminocyclohexane)bis(2-tert-butoxyacetate)platinum(II)","(diaminocyclohexane)bis(2-tert-butoxyacetate)platinum(II)","C562059","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2011,"21726773","Antitumor activities and interaction with DNA of oxaliplatin-type platinum complexes with linear or branched alkoxyacetates as leaving groups.","21726773",136]
["(dichloro)tetraammineruthenium(III)","(dichloro)tetraammineruthenium(III)","C543901","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"20600797","The compound cis-(dichloro)tetrammineruthenium(III) chloride induces caspase-mediated apoptosis in K562 cells.","20600797",136]
["(dichloro)tetraammineruthenium(III)","(dichloro)tetraammineruthenium(III)","C543901","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22144016","Induction of cell cycle arrest and apoptosis by ruthenium complex cis-(dichloro)tetramineruthenium(III) chloride in human lung carcinoma cells A549.","22144016",136]
["(dichloro)tetraammineruthenium(III)","(dichloro)tetraammineruthenium(III)","C543901","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24781824","The ruthenium complexes cis-(dichloro)tetramineruthenium(III) chloride and cis-tetraammine(oxalato)ruthenium(III) dithionate overcome resistance inducing apoptosis on human lung carcinoma cells (A549).","24781824",136]
["(dichloro)tetraammineruthenium(III)","(dichloro)tetraammineruthenium(III)","C543901","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2010,"19590831","The ruthenium complex cis-(Dichloro)Tetraammineruthenium(III) chloride presents immune stimulatory activity on human peripheral blood mononuclear cells.","19590831",136]
["(dichloro)tetraammineruthenium(III)","(dichloro)tetraammineruthenium(III)","C543901","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"19727575","The ruthenium complex cis-(dichloro)tetraammineruthenium(III) chloride presents selective cytotoxicity against murine B cell lymphoma (A-20), murine ascitic sarcoma 180 (S-180), human breast adenocarcinoma (SK-BR-3), and human T cell leukemia (Jurkat) tumor cell lines.","19727575",136]
["(diethoxyphosphoryl)-5-methylpyrroline N-oxide","(diethoxyphosphoryl)-5-methylpyrroline N-oxide","C510912","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2006,"17050170","Synthesis and characterization of a practically better DEPMPO-type spin trap, 5-(2,2-dimethyl-1,3-propoxy cyclophosphoryl)-5-methyl-1-pyrroline N-oxide (CYPMPO).","17050170",136]
["(diethylenetriamine)(imidazoline)copper(II) perchlorate","(diethylenetriamine)(imidazoline)copper(II) perchlorate","C500448","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2005,"15556452","Novel copper(II)-dien-imidazole/imidazolate-bridged copper(II) complexes. Crystal structure of [Cu(dien)(Him)](ClO4)2 and of [(dien)Cu(mu-im)Cu(dien)](ClO4)3, a homobinuclear model for the copper(II) site of the CuZn-superoxide dismutase.","15556452",136]
["(diethylenetriamine)-platinum(II)","(diethylenetriamine)-platinum(II)","C438825","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2001,"11405468","Formation of ternary complexes by coordination of (diethylenetriamine)-platinum(II) to N1 or N7 of the adenine moiety of the antiviral nucleotide analogue 9.","11405468",136]
["(dimethoxyphosphoryl)methyl 2-methylacrylate","(dimethoxyphosphoryl)methyl 2-methylacrylate","C582225","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2013,"23508140","Removal of metal ions from aqueous effluents involving new thermosensitive polymeric sorbent.","23508140",136]
["(E)-((3-cyclopentyloxy-4-methoxyphenyl)methylene)-hydrazinecarboxamide","(E)-((3-cyclopentyloxy-4-methoxyphenyl)methylene)-hydrazinecarboxamide","C483181","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Atrophy","D001284","Atrophy",1,2,2004,"14871579","Subacute toxicity and toxicokinetics of CJ-10882, a type IV phosphodiesterase inhibitor, after 4-week repeated oral administration in dogs.","14871579",136]
["(E)-1-(2,3,6-trimethylphenyl)buta-1,3-diene","(E)-1-(2,3,6-trimethylphenyl)buta-1,3-diene","C504097","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2005,"16104799","Generation of (E)-1-(2,3,6-trimethylphenyl)buta-1,3-diene from C13-norisoprenoid precursors.","16104799",136]
["(E)-1-(2'-hydroxy-4',6'-dimethoxyphenyl)-3-(4-methylthio)phenyl)prop-2-ene-1-one","(E)-1-(2'-hydroxy-4',6'-dimethoxyphenyl)-3-(4-methylthio)phenyl)prop-2-ene-1-one","C000617911","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27358555","Flavokawain derivative FLS induced G2/M arrest and apoptosis on breast cancer MCF-7 cell line.","27358555",136]
["(E)-1-(2'-hydroxy-4',6'-dimethoxyphenyl)-3-(4-methylthio)phenyl)prop-2-ene-1-one","(E)-1-(2'-hydroxy-4',6'-dimethoxyphenyl)-3-(4-methylthio)phenyl)prop-2-ene-1-one","C000617911","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27358555","Flavokawain derivative FLS induced G2/M arrest and apoptosis on breast cancer MCF-7 cell line.","27358555",136]
["(E)-1-(2-hydroxyphenyl)-3-(2-methoxynaphthalen-1-yl)prop-2-en-1-one","(E)-1-(2-hydroxyphenyl)-3-(2-methoxynaphthalen-1-yl)prop-2-en-1-one","C000619667","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27641669","p53-dependent and -independent mechanisms are involved in (E)-1-(2-hydroxyphenyl)-3-(2-methoxynaphthalen-1-yl)prop-2-en-1-one (HMP)-induced apoptosis in HCT116 colon cancer cells.","27641669",136]
["(E)-1-(2-nitrovinyl)naphthalene","(E)-1-(2-nitrovinyl)naphthalene","C000599592","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2015,"25795708","Nitrostyrene Derivatives Act as RXRα Ligands to Inhibit TNFα Activation of NF-κB.","25795708",136]
["(E)-1-(3,4-dihydroxyphenethyl)-3-styrylurea","(E)-1-(3,4-dihydroxyphenethyl)-3-styrylurea","C548394","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2009,"20044952","Induction of caspase-dependent apoptosis in melanoma cells by the synthetic compound (E)-1-(3,4-dihydroxyphenethyl)-3-styrylurea.","20044952",136]
["(E)-1-(3,4-dihydroxyphenethyl)-3-styrylurea","(E)-1-(3,4-dihydroxyphenethyl)-3-styrylurea","C548394","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"20811815","(E)-1-(3,4-dihydroxyphenethyl)-3-styrylurea inhibits proliferation of MCF-7 cells through G1 cell cycle arrest and mitochondria-mediated apoptosis.","20811815",136]
["(E)-1-(3,4-dihydroxyphenethyl)-3-styrylurea","(E)-1-(3,4-dihydroxyphenethyl)-3-styrylurea","C548394","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"20044952","Induction of caspase-dependent apoptosis in melanoma cells by the synthetic compound (E)-1-(3,4-dihydroxyphenethyl)-3-styrylurea.","20044952",136]
["(E)-1-(3,4-dihydroxyphenethyl)-3-styrylurea","(E)-1-(3,4-dihydroxyphenethyl)-3-styrylurea","C548394","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20811815","(E)-1-(3,4-dihydroxyphenethyl)-3-styrylurea inhibits proliferation of MCF-7 cells through G1 cell cycle arrest and mitochondria-mediated apoptosis.","20811815",136]
["(E)-1-(3,4-dihydroxyphenethyl)-3-styrylurea","(E)-1-(3,4-dihydroxyphenethyl)-3-styrylurea","C548394","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24905050","A phenolic acid phenethyl urea derivative protects against irradiation-induced osteoblast damage by modulating intracellular redox state.","24905050",136]
["(E)-1-(3'-fluoro-(1,1'-biphenyl-3-yl)-3-(3-hydroxy-4-methoxyphenyl)prop-2-en-1-one)","(E)-1-(3'-fluoro-(1,1'-biphenyl-3-yl)-3-(3-hydroxy-4-methoxyphenyl)prop-2-en-1-one)","C000617793","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28024945","MC37, a new mono-carbonyl curcumin analog, induces G2/M cell cycle arrest and mitochondria-mediated apoptosis in human colorectal cancer cells.","28024945",136]
["(E)-1-(4-tert-butylbenzyl)-N'-(1-(5-chloro-2-hydroxyphenyl) ethylidene)-3-(4-chlorophenyl)-1H-pyrazole-5-carbohydrazide","(E)-1-(4-tert-butylbenzyl)-N'-(1-(5-chloro-2-hydroxyphenyl) ethylidene)-3-(4-chlorophenyl)-1H-pyrazole-5-carbohydrazide","C540832","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2009,"19217789","Synthesis of novel substituted pyrazole-5-carbohydrazide hydrazone derivatives and discovery of a potent apoptosis inducer in A549 lung cancer cells.","19217789",136]
["(E)-3-(1H-Indol-3-yl)-N-(2,4,6-trimethoxyphenyl)acrylamide","(E)-3-(1H-Indol-3-yl)-N-(2,4,6-trimethoxyphenyl)acrylamide","C000600993","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24816066","Synthesis, biological evaluation and molecular docking studies of trans-indole-3-acrylamide derivatives, a new class of tubulin polymerization inhibitors.","24816066",136]
["(E)-3-(1H-Indol-3-yl)-N-(2,4,6-trimethoxyphenyl)acrylamide","(E)-3-(1H-Indol-3-yl)-N-(2,4,6-trimethoxyphenyl)acrylamide","C000600993","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24816066","Synthesis, biological evaluation and molecular docking studies of trans-indole-3-acrylamide derivatives, a new class of tubulin polymerization inhibitors.","24816066",136]
["(E)-3-(2-bromophenyl)-N-(4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)phenyl)acrylamide","(E)-3-(2-bromophenyl)-N-(4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)phenyl)acrylamide","C546525","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"19924055","Design and synthesis of novel 2-phenylaminopyrimidine (PAP) derivatives and their antiproliferative effects in human chronic myeloid leukemia cells.","19924055",136]
["(E)-3-(5-(5-chloro-2,4-dihydroxyphenyl)-4-(4-hydroxyphenyl)isoxazol-3-yl)-1-(4-(2-methoxyphenyl)piperazin-1-yl)prop-2-en-1-one","(E)-3-(5-(5-chloro-2,4-dihydroxyphenyl)-4-(4-hydroxyphenyl)isoxazol-3-yl)-1-(4-(2-methoxyphenyl)piperazin-1-yl)prop-2-en-1-one","C000595383","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"25383915","Discovery and optimization of 4,5-diarylisoxazoles as potent dual inhibitors of pyruvate dehydrogenase kinase and heat shock protein 90.","25383915",136]
["(E)-3-(hydroxy(4-nitrophenyl)methyl)-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one","(E)-3-(hydroxy(4-nitrophenyl)methyl)-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one","C583250","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23668860","Synthesis, anticancer, and antibacterial activities of piplartine derivatives on cell cycle regulation and growth inhibition.","23668860",136]
["(E)-3-(hydroxy(phenyl)methyl)-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one","(E)-3-(hydroxy(phenyl)methyl)-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one","C583249","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23668860","Synthesis, anticancer, and antibacterial activities of piplartine derivatives on cell cycle regulation and growth inhibition.","23668860",136]
["(E)-3-(hydroxy(thiophen-2-yl)methyl)-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one","(E)-3-(hydroxy(thiophen-2-yl)methyl)-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one","C583248","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23668860","Synthesis, anticancer, and antibacterial activities of piplartine derivatives on cell cycle regulation and growth inhibition.","23668860",136]
["(E)-4-(ethoxymethylene)-2-phenyloxazol-5(4H)-one","(E)-4-(ethoxymethylene)-2-phenyloxazol-5(4H)-one","C570750","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2010,"20866106","Chemical basis for the extreme skin sensitization potency of (E)-4-(ethoxymethylene)-2-phenyloxazol-5(4H)-one.","20866106",136]
["(E)-4-carboxystyryl-4-chlorobenzylsulfone, sodium salt","(E)-4-carboxystyryl-4-chlorobenzylsulfone, sodium salt","C520364","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22264334","Administration of ON 01210.Na after exposure to ionizing radiation protects bone marrow cells by attenuating DNA damage response.","22264334",136]
["(E)-4-carboxystyryl-4-chlorobenzylsulfone, sodium salt","(E)-4-carboxystyryl-4-chlorobenzylsulfone, sodium salt","C520364","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28901519","Salidroside, a scavenger of ROS, enhances the radioprotective effect of Ex-RAD® via a p53-dependent apoptotic pathway.","28901519",136]
["(E)-4-carboxystyryl-4-chlorobenzylsulfone, sodium salt","(E)-4-carboxystyryl-4-chlorobenzylsulfone, sodium salt","C520364","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23505494","ON01210.Na (Ex-RAD®) mitigates radiation damage through activation of the AKT pathway.","23505494",136]
["(E)-4-hydroxy-3-methylbut-2-enyl diphosphate","(E)-4-hydroxy-3-methylbut-2-enyl diphosphate","C547602","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"26475929","Sensor Function for Butyrophilin 3A1 in Prenyl Pyrophosphate Stimulation of Human Vγ2Vδ2 T Cells.","26475929",136]
["(E)-4-hydroxy-3-methylbut-2-enyl diphosphate","(E)-4-hydroxy-3-methylbut-2-enyl diphosphate","C547602","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28631855","A Photo-Crosslinkable Biotin Derivative of the Phosphoantigen (E)-4-Hydroxy-3-Methylbut-2-Enyl Diphosphate (HMBPP) Activates Vγ9Vδ2 T Cells and Binds to the HMBPP Site of BTN3A1.","28631855",136]
["(E)-8-acetoxy-2-(2-(3,4-diacetoxyphenyl)ethenyl)quinazoline","(E)-8-acetoxy-2-(2-(3,4-diacetoxyphenyl)ethenyl)quinazoline","C000615691","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27748905","Resveratrol analogue (E)-8-acetoxy-2-[2-(3,4-diacetoxyphenyl)ethenyl]-quinazoline induces apoptosis via Fas-mediated pathway in HL-60 human leukemia cells.","27748905",136]
["(E)-9-(2-nitrovinyl)anthracene","(E)-9-(2-nitrovinyl)anthracene","C000599593","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2015,"25795708","Nitrostyrene Derivatives Act as RXRα Ligands to Inhibit TNFα Activation of NF-κB.","25795708",136]
["(E)-9-(2-nitrovinyl)anthracene","(E)-9-(2-nitrovinyl)anthracene","C000599593","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2015,"25804511","A new fluorescent enhanced probe based on (E)-9-(2-nitrovinyl)-anthracene for the detection of bisulfite anions and its practical application.","25804511",136]
["(E)-alpha-benzylthio chalcone","(E)-alpha-benzylthio chalcone","C549755","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20188579","Design, synthesis and evaluation of (E)-alpha-benzylthio chalcones as novel inhibitors of BCR-ABL kinase.","20188579",136]
["(E)-methyl 2-(7-chloroquinolin-4-ylthio)-3-(4-hydroxyphenyl)acrylate","(E)-methyl 2-(7-chloroquinolin-4-ylthio)-3-(4-hydroxyphenyl)acrylate","C000589136","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23137315","Potential antitumour and pro-oxidative effects of (E)-methyl 2-(7-chloroquinolin-4-ylthio)-3-(4-hydroxyphenyl) acrylate (QNACR).","23137315",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C643,B643)","v":"(E)-oxindolylidene acetate"},"(E)-oxindolylidene acetate","C000610865","3_KE",870,3,"Cell Proliferation","Increase",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J643,K643)","v":"Cell Proliferation"},"D049109","Cell Proliferation",1,2,2016,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q643,Q643)","v":"26552357"},"Synthesis of (E)-oxindolylidene acetate using tandem palladium-catalyzed Heck and alkoxycarbonylation reactions.","26552357",136]
["(eta(5)-cyclopentadienyl)(1,2-bis(diphenylphosphine)ethane)(1,3,5-triazine)ruthenium(II)","(eta(5)-cyclopentadienyl)(1,2-bis(diphenylphosphine)ethane)(1,3,5-triazine)ruthenium(II)","C539770","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"19128838","Inhibition of cancer cell growth by ruthenium(II) cyclopentadienyl derivative complexes with heteroaromatic ligands.","19128838",136]
["(eta(5)-cyclopentadienyl)(pyridazine)bis(triphenyphosphine)ruthenium(II)","(eta(5)-cyclopentadienyl)(pyridazine)bis(triphenyphosphine)ruthenium(II)","C539771","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"19128838","Inhibition of cancer cell growth by ruthenium(II) cyclopentadienyl derivative complexes with heteroaromatic ligands.","19128838",136]
["(eta6-p-cymene)Ru(9-aminoacridine)Cl","(eta6-p-cymene)Ru(9-aminoacridine)Cl","C543743","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"19562164","A novel ruthenium(II) arene based intercalator with potent anticancer activity.","19562164",136]
["(ethanol)(2,3,7,8,12,13,17,18-octaethylporphinato)manganese(III) perchlorate","(ethanol)(2,3,7,8,12,13,17,18-octaethylporphinato)manganese(III) perchlorate","C103292","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1996,"9004732","(Ethanol)(2,3,7,8,12,13,17,18-octaethylporphinato)manganese(III) perchlorate.","9004732",136]
["(ethylenedinitrilo)-tetramethylenephosphonic acid","(ethylenedinitrilo)-tetramethylenephosphonic acid","C018940","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2003,"12641289","Interaction of immunoglobulin G with N,N,N',N'-ethylenediaminetetramethylenephosphonic acid-modified zirconia.","12641289",136]
["(ethylenedinitrilo)-tetramethylenephosphonic acid","(ethylenedinitrilo)-tetramethylenephosphonic acid","C018940","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1982,"6293678","In vitro evaluation of editempa on hydroxyapatite formation and its effects on dental enamel.","6293678",136]
["(Fe(III)Mn(II)(BPBPMP)(OAc)(2))ClO(4)","(Fe(III)Mn(II)(BPBPMP)(OAc)(2))ClO(4)","C472285","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2002,"12206683","Synthesis, structure, properties, and phosphatase-like activity of the first heterodinuclear Fe(III)Mn(II) complex with the unsymmetric ligand H(2)BPBPMP as a model for the PAP in sweet potato.","12206683",136]
["(fluorescein-6-carbonyloxy)acetoaminomethylene bisphosphonic acid","(fluorescein-6-carbonyloxy)acetoaminomethylene bisphosphonic acid","C104510","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1996,"8887727","Physicochemical characterization of bisphosphonic carboxyfluorescein for osteotropic drug delivery.","8887727",136]
["(glycinato-kappa(2)N,O)oxidobis(peroxido-kappa(2)O,O')vanadate(V) tetrahydrate","(glycinato-kappa(2)N,O)oxidobis(peroxido-kappa(2)O,O')vanadate(V) tetrahydrate","C587648","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2013,"24311498","Calcium and strontium salts of (glycinato-κ(2)N,O)oxidobis(peroxido-κ(2)O,O')vanadate(V) tetrahydrate.","24311498",136]
["(isonicotinic acid (2-(4,4,5,5-tetramethyl-(1,3,2)dioxaborolan-2-yl)benzylidene)hydrazide)","(isonicotinic acid (2-(4,4,5,5-tetramethyl-(1,3,2)dioxaborolan-2-yl)benzylidene)hydrazide)","C541518","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2008,"18835041","Iron prochelator BSIH protects retinal pigment epithelial cells against cell death induced by hydrogen peroxide.","18835041",136]
["(lactide-co-glycolide)-monomethoxy-poly(polyethylene glycol)","(lactide-co-glycolide)-monomethoxy-poly(polyethylene glycol)","C000614851","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2016,"26203690","A novel ligand conjugated nanoparticles for oral insulin delivery.","26203690",136]
["(M)-bicelaphanol A","(M)-bicelaphanol A","C582699","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23746757","Promising effects on ameliorating mitochondrial function and enhancing Akt signaling in SH-SY5Y cells by (M)-bicelaphanol A, a novel dimeric podocarpane type trinorditerpene isolated from Celastrus orbiculatus.","23746757",136]
["(meso-tetrakis(sulfonatomesityl)porphyrinato)iron(III)","(meso-tetrakis(sulfonatomesityl)porphyrinato)iron(III)","C521848","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"17366654","Mechanistic studies on peroxide activation by a water-soluble iron(III)-porphyrin: implications for O-O bond activation in aqueous and nonaqueous solvents.","17366654",136]
["(methyl 2,3,6-trideoxy-alpha-talopyranosido)-(3,2-d)-2-cyclohexanone","(methyl 2,3,6-trideoxy-alpha-talopyranosido)-(3,2-d)-2-cyclohexanone","C045834","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1985,"4005893","Second generation alpha-enones from a pyranosidic alpha-enone.","4005893",136]
["(MnIV4O5(terpy)4(H2O)2)(ClO4)6","(MnIV4O5(terpy)4(H2O)2)(ClO4)6","C490328","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2004,"15186173","Dimer-of-dimers model for the oxygen-evolving complex of photosystem II. Synthesis and properties of [MnIV4O5(terpy)4(H2O)2](ClO4)6.","15186173",136]
["(mu4-oxo)tetra-mu4-acetate(4-hydroxy-3,5-bis(morpholinomethyl))tetracopper(II)","(mu4-oxo)tetra-mu4-acetate(4-hydroxy-3,5-bis(morpholinomethyl))tetracopper(II)","C585577","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"24012731","Cytotoxic, pro-apoptotic, pro-oxidant, and non-genotoxic activities of a novel copper(II) complex against human cervical cancer.","24012731",136]
["(N(1),N(12))bis(ethyl)-6,7-dehydrospermine","(N(1),N(12))bis(ethyl)-6,7-dehydrospermine","C415967","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2006,"16697514","Differential polyamine analogue effects in four human breast cancer cell lines.","16697514",136]
["(N(1),N(12))bis(ethyl)-6,7-dehydrospermine","(N(1),N(12))bis(ethyl)-6,7-dehydrospermine","C415967","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2009,"20003408","A systems analysis of the chemosensitivity of breast cancer cells to the polyamine analogue PG-11047.","20003408",136]
["(N(1),N(12))bis(ethyl)-6,7-dehydrospermine","(N(1),N(12))bis(ethyl)-6,7-dehydrospermine","C415967","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"20003408","A systems analysis of the chemosensitivity of breast cancer cells to the polyamine analogue PG-11047.","20003408",136]
["(N(1),N(12))bis(ethyl)-6,7-dehydrospermine","(N(1),N(12))bis(ethyl)-6,7-dehydrospermine","C415967","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28423064","Biochemical evaluation of the anticancer potential of the polyamine-based nanocarrier Nano11047.","28423064",136]
["(N'-(2-hydroxybenzylidene)-1-benzyl-3-phenyl-1H-pyrazole-5-carbohydrazide)copper(II)","(N'-(2-hydroxybenzylidene)-1-benzyl-3-phenyl-1H-pyrazole-5-carbohydrazide)copper(II)","C545878","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2009,"19621939","Novel complex of copper and a salicylaldehyde pyrazole hydrazone derivative induces apoptosis through up-regulating integrin beta 4 in vascular endothelial cells.","19621939",136]
["(N-(3,5-dichloro-2-oxidobenzylidene)-4-chlorobenzyhydrazidato)(o-methylbenzyl)aquatin(IV)","(N-(3,5-dichloro-2-oxidobenzylidene)-4-chlorobenzyhydrazidato)(o-methylbenzyl)aquatin(IV)","C000610766","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"26648695","Synthesis, structural characterization, and anticancer activity of a monobenzyltin compound against MCF-7 breast cancer cells.","26648695",136]
["(N-(3,5-dichloro-2-oxidobenzylidene)-4-chlorobenzyhydrazidato)(o-methylbenzyl)aquatin(IV)","(N-(3,5-dichloro-2-oxidobenzylidene)-4-chlorobenzyhydrazidato)(o-methylbenzyl)aquatin(IV)","C000610766","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"26648695","Synthesis, structural characterization, and anticancer activity of a monobenzyltin compound against MCF-7 breast cancer cells.","26648695",136]
["(N-(4-(2,2,2-trifluoroethyl) benzylidene) (7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthren-1-yl) meth-anamine)","(N-(4-(2,2,2-trifluoroethyl) benzylidene) (7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthren-1-yl) meth-anamine)","C527614","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2008,"18237468","Cytotoxic effects and pro-apoptotic mechanism of TBIDOM, a novel dehydroabietylamine derivative, on human hepatocellular carcinoma SMMC-7721 cells.","18237468",136]
["(N-(4-(2,2,2-trifluoroethyl) benzylidene) (7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthren-1-yl) meth-anamine)","(N-(4-(2,2,2-trifluoroethyl) benzylidene) (7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthren-1-yl) meth-anamine)","C527614","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2008,"18237468","Cytotoxic effects and pro-apoptotic mechanism of TBIDOM, a novel dehydroabietylamine derivative, on human hepatocellular carcinoma SMMC-7721 cells.","18237468",136]
["(N(6)-adenyl)styrene oxide","(N(6)-adenyl)styrene oxide","C440254","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2001,"11502171","The nonmutagenic (R)- and (S)-beta-(N(6)-adenyl)styrene oxide adducts are oriented in the major groove and show little perturbation to DNA structure.","11502171",136]
["(N-(N',N'-dimethylaminoethyl)-1,8-naphthalimide-4-sulfide)(triethylphosphine)gold(I)","(N-(N',N'-dimethylaminoethyl)-1,8-naphthalimide-4-sulfide)(triethylphosphine)gold(I)","C538800","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2009,"19123857","A gold(I) phosphine complex containing a naphthalimide ligand functions as a TrxR inhibiting antiproliferative agent and angiogenesis inhibitor.","19123857",136]
["(N,N'-bis(quinolin-2-yl-methylidene)octa-4-ene-2,6-diyne-1,8-diamine)zinc(II) chloride","(N,N'-bis(quinolin-2-yl-methylidene)octa-4-ene-2,6-diyne-1,8-diamine)zinc(II) chloride","C567984","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"21756041","Potentiation of metalloenediyne cytotoxicity by hyperthermia.","21756041",136]
["(N,N-diethylamino)-4-hydroxyflavylium","(N,N-diethylamino)-4-hydroxyflavylium","C528790","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2008,"18290679","Photochromic soft materials: flavylium compounds incorporated into pluronic F-127 hydrogel matrixes.","18290679",136]
["(N',N''E,N',N''E)-N',N''-(((propane-1,3-diylbis(oxy))bis(2,1-phenylene))bis(methanylylidene))di(isonicotinohydrazide)","(N',N''E,N',N''E)-N',N''-(((propane-1,3-diylbis(oxy))bis(2,1-phenylene))bis(methanylylidene))di(isonicotinohydrazide)","C000603139","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2015,"25746253","Nano-level monitoring of Mn(2+) ion by fabrication of coated pyrolytic graphite electrode based on isonicotinohydrazide derivatives.","25746253",136]
["(NH4)4H4(Se2Mo2V4O24).7H2O","(NH4)4H4(Se2Mo2V4O24).7H2O","C569095","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"21887468","The novel selenium heteropoly compound (NH₄)₄H₄[Se₂Mo₂V₄O₂₄]·7H₂O induces apoptosis of K562 cells.","21887468",136]
["(NH4)4H4(Se2Mo2V4O24).7H2O","(NH4)4H4(Se2Mo2V4O24).7H2O","C569095","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2011,"21887468","The novel selenium heteropoly compound (NH₄)₄H₄[Se₂Mo₂V₄O₂₄]·7H₂O induces apoptosis of K562 cells.","21887468",136]
["(Ni(Py-3')TPP-Ru(phen)2Cl)(PF6)","(Ni(Py-3')TPP-Ru(phen)2Cl)(PF6)","C547323","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2010,"19958751","DNA binding and photocleavage properties and apoptosis-inducing activities of a ruthenium porphyrin complex [(Py-3')TPP-Ru(phen)2Cl]Cl and its heterometallic derivatives.","19958751",136]
["(nitrilotris(methylene))triphosphonic acid","(nitrilotris(methylene))triphosphonic acid","C041182","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"17899886","Potentiometric studies of binary and ternary complexes involving cadmium(II) and nitrilo-tris(methyl phosphonic acid) with amino acids, peptides and DNA constituents.","17899886",136]
["(nitrilotris(methylene))triphosphonic acid","(nitrilotris(methylene))triphosphonic acid","C041182","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2010,"20667427","Adsorptive removal of nitrilotris(methylenephosphonic acid) antiscalant from membrane concentrates by iron-coated waste filtration sand.","20667427",136]
["(N-methoxy-N-methyl)-4-(5-benzoylbenzimidazole-2-yl)-3,5-dimethylpyrrole-2-carboxamide hydrochloride","(N-methoxy-N-methyl)-4-(5-benzoylbenzimidazole-2-yl)-3,5-dimethylpyrrole-2-carboxamide hydrochloride","C568815","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Nasal Mucosa","D009297","Nasal Mucosa",1,2,2011,"21645503","Role of hematopoietic prostaglandin D synthase in biphasic nasal obstruction in guinea pig model of experimental allergic rhinitis.","21645503",136]
["(N-propargyl-(3R) aminoindan-5-yl)-ethyl methyl carbamate","(N-propargyl-(3R) aminoindan-5-yl)-ethyl methyl carbamate","C423264","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2001,"12043833","Molecular basis of neuroprotective activities of rasagiline and the anti-Alzheimer drug TV3326 [(N-propargyl-(3R)aminoindan-5-YL)-ethyl methyl carbamate].","12043833",136]
["(N-propargyl-(3R) aminoindan-5-yl)-ethyl methyl carbamate","(N-propargyl-(3R) aminoindan-5-yl)-ethyl methyl carbamate","C423264","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2003,"12697291","Anti-apoptotic action of anti-Alzheimer drug, TV3326 [(N-propargyl)-(3R)-aminoindan-5-yl]-ethyl methyl carbamate, a novel cholinesterase-monoamine oxidase inhibitor.","12697291",136]
["(N-propargyl-(3R) aminoindan-5-yl)-ethyl methyl carbamate","(N-propargyl-(3R) aminoindan-5-yl)-ethyl methyl carbamate","C423264","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2006,"16935943","A multifunctional, neuroprotective drug, ladostigil (TV3326), regulates holo-APP translation and processing.","16935943",136]
["(N-propargyl-(3R) aminoindan-5-yl)-ethyl methyl carbamate","(N-propargyl-(3R) aminoindan-5-yl)-ethyl methyl carbamate","C423264","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2007,"17635668","Aminoindan and hydroxyaminoindan, metabolites of rasagiline and ladostigil, respectively, exert neuroprotective properties in vitro.","17635668",136]
["(N-salicylidene-L-glutamato)copper(II) monohydrate","(N-salicylidene-L-glutamato)copper(II) monohydrate","C530823","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2008,"18505346","Cytotoxicity of copper(II) complexes of N-salicylidene-L-glutamate: modulation by ascorbic acid.","18505346",136]
["(N-salicylidene-L-glutamato)copper(II) monohydrate","(N-salicylidene-L-glutamato)copper(II) monohydrate","C530823","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"24113525","Effect of the Schiff base complex diaqua-(N-salicylidene-l-glutamato)copper(II) monohydrate on human tumor cells.","24113525",136]
["(polyethylene-acrylic acid) copolymer","(polyethylene-acrylic acid) copolymer","C083316","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20597124","Novel poly(ethylene-co-acrylic acid) nanofibrous biomaterials for peptide synthesis and biomedical applications.","20597124",136]
["(polyethyleneiminomethyl phosphonate)tin(II)","(polyethyleneiminomethyl phosphonate)tin(II)","C489335","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2009,"19437756","Hydroxyapatite chemisorption of N,N',N'-trimethylenephosphonate-poly(ethyleneimine) (PEI-MP) combined with Sn2+ or Sn4+.","19437756",136]
["(Pt(2-methylthiomethylpyridine)(OH2)2)2","(Pt(2-methylthiomethylpyridine)(OH2)2)2","C572366","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"22042552","Thermodynamic and kinetic behaviour of [Pt(2-methylthiomethylpyridine)(OH2)2]2+.","22042552",136]
["(Pt(NH(3))(achsh)Cl(2))","(Pt(NH(3))(achsh)Cl(2))","C460960","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2002,"12062124","Synthesis, cytotoxicity, antibacterial and antitumor activity of platinum(II) complexes of 3-aminocyclohexanespiro-5-hydantoin.","12062124",136]
["(R)-1-(1H-indol-3-yl)-2-phenylmethanesulfonyl-1,2,3,4-tetrahydroisoquinoline","(R)-1-(1H-indol-3-yl)-2-phenylmethanesulfonyl-1,2,3,4-tetrahydroisoquinoline","C551678","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23341130","A novel small molecule RAD51 inactivator overcomes imatinib-resistance in chronic myeloid leukaemia.","23341130",136]
["(R)-1-(1H-indol-3-yl)-2-phenylmethanesulfonyl-1,2,3,4-tetrahydroisoquinoline","(R)-1-(1H-indol-3-yl)-2-phenylmethanesulfonyl-1,2,3,4-tetrahydroisoquinoline","C551678","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23341130","A novel small molecule RAD51 inactivator overcomes imatinib-resistance in chronic myeloid leukaemia.","23341130",136]
["(R)-1-(1H-indol-3-yl)-2-phenylmethanesulfonyl-1,2,3,4-tetrahydroisoquinoline","(R)-1-(1H-indol-3-yl)-2-phenylmethanesulfonyl-1,2,3,4-tetrahydroisoquinoline","C551678","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"29061656","Synergistic antiproliferative activity of the RAD51 inhibitor IBR2 with inhibitors of receptor tyrosine kinases and microtubule protein.","29061656",136]
["(R)-1-O-(4-(1-pyrenylethynyl)phenylmethyl)glycerol","(R)-1-O-(4-(1-pyrenylethynyl)phenylmethyl)glycerol","C507245","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"19099510","Identification of a new G-quadruplex motif in the KRAS promoter and design of pyrene-modified G4-decoys with antiproliferative activity in pancreatic cancer cells.","19099510",136]
["(R)-2-(3-((benzoxazol-2-yl-d4 (3-(4-methoxyphenoxy-d7)propyl)amino)methyl)phenoxy) butanoic acid","(R)-2-(3-((benzoxazol-2-yl-d4 (3-(4-methoxyphenoxy-d7)propyl)amino)methyl)phenoxy) butanoic acid","C540740","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2009,"18606415","Newly developed PPAR-alpha agonist (R)-K-13675 inhibits the secretion of inflammatory markers without affecting cell proliferation or tube formation.","18606415",136]
["(R)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide","(R)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide","C000619999","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27739677","Identification of (R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitable for Phase I Clinical Trials for B-Cell Lymphomas.","27739677",136]
["(R,E)-N-(1-hydroxy-4-(tridecylthio)but-3-en-2-yl)octanamide","(R,E)-N-(1-hydroxy-4-(tridecylthio)but-3-en-2-yl)octanamide","C574152","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22537678","3-Deoxy-3,4-dehydro analogs of XM462. Preparation and activity on sphingolipid metabolism and cell fate.","22537678",136]
["(R,E)-N-(1-hydroxy-4-(tridecylthio)but-3-en-2-yl)pivalamide","(R,E)-N-(1-hydroxy-4-(tridecylthio)but-3-en-2-yl)pivalamide","C574131","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22537678","3-Deoxy-3,4-dehydro analogs of XM462. Preparation and activity on sphingolipid metabolism and cell fate.","22537678",136]
["(R,E)-N-(7-chloro-1-(1-(4-(dimethylamino)but-2-enoyl)azepan-3-yl)-1H-benzo(d)imidazol-2-yl)-2-methylisonicotinamide","(R,E)-N-(7-chloro-1-(1-(4-(dimethylamino)but-2-enoyl)azepan-3-yl)-1H-benzo(d)imidazol-2-yl)-2-methylisonicotinamide","C000619734","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27433829","Discovery of (R,E)-N-(7-Chloro-1-(1-[4-(dimethylamino)but-2-enoyl]azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide (EGF816), a Novel, Potent, and WT Sparing Covalent Inhibitor of Oncogenic (L858R, ex19del) and Resistant (T790M) EGFR Mutants for the Treatment of EGFR Mutant Non-Small-Cell Lung Cancers.","27433829",136]
["(R,S)-2-((8-chlorobenzofurano(2,3-b)quinolinyl)oxy)propionic acid","(R,S)-2-((8-chlorobenzofurano(2,3-b)quinolinyl)oxy)propionic acid","C511151","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2006,"16337128","Synthesis and biological evaluation of conformationally constrained analogs of the antitumor agents XK469 and SH80. Part 5.","16337128",136]
["(R,S)-4-((4'-hydroxy-3-((4-hydroxyphenyl)ethynyl)biphenyl-2-yl)(4-hydroxyphenyl)methylene)-2,5-cyclohexadien-1-one","(R,S)-4-((4'-hydroxy-3-((4-hydroxyphenyl)ethynyl)biphenyl-2-yl)(4-hydroxyphenyl)methylene)-2,5-cyclohexadien-1-one","C530550","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22964466","Inhibitory effect of selaginellin on high glucose-induced apoptosis in differentiated PC12 cells: role of NADPH oxidase and LOX-1.","22964466",136]
["(Rh(bpy)2(chrysi))3+","(Rh(bpy)2(chrysi))3+","C409422","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"22103240","Selective cytotoxicity of rhodium metalloinsertors in mismatch repair-deficient cells.","22103240",136]
["(Rh(bpy)2(chrysi))3+","(Rh(bpy)2(chrysi))3+","C409422","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,2,2011,"22103240","Selective cytotoxicity of rhodium metalloinsertors in mismatch repair-deficient cells.","22103240",136]
["(Ru(bpy)2(Hbopip))(ClO4)2","(Ru(bpy)2(Hbopip))(ClO4)2","C513694","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2006,"16471826","Ruthenium(II) complex of Hbopip: synthesis, characterization, pH-induced luminescence \"off-on-off\" switch, and avid binding to DNA.","16471826",136]
["(ruthenium(1,4,5,8-tetraazaphenanthrene)(2)5-(4-(N-methyl-N-(7-chloroquinolin-4-yl)amino)-2-thiabutylcarboxamido)1,10-phenanthroline)","(ruthenium(1,4,5,8-tetraazaphenanthrene)(2)5-(4-(N-methyl-N-(7-chloroquinolin-4-yl)amino)-2-thiabutylcarboxamido)1,10-phenanthroline)","C453179","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2002,"11849097","Novel DNA sensor for guanine content.","11849097",136]
["(S)-1-((S)-2-amino-3-(4-(1-(4-fluorobenzyl)-1H-1,2,3-triazol-4-yl)phenyl)propanoyl)pyrrolidine-2-carbonitrile hydrochloride","(S)-1-((S)-2-amino-3-(4-(1-(4-fluorobenzyl)-1H-1,2,3-triazol-4-yl)phenyl)propanoyl)pyrrolidine-2-carbonitrile hydrochloride","C587123","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23932071","Exploration of N-(2-aminoethyl)piperidine-4-carboxamide as a potential scaffold for development of VEGFR-2, ERK-2 and Abl-1 multikinase inhibitor.","23932071",136]
["(S)-1-(1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one","(S)-1-(1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one","C000619637","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27227380","Discovery of (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one (GDC-0994), an Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical Development.","27227380",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C707,B707)","v":"(S)-1-(3-((2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)phenyl)amino)-1-(tetrahydrofuran-3-yl)-6,7-dihydro-1H-pyrazolo(4,3-c)pyridin-5(4H)-yl)ethanone"},"(S)-1-(3-((2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)phenyl)amino)-1-(tetrahydrofuran-3-yl)-6,7-dihydro-1H-pyrazolo(4,3-c)pyridin-5(4H)-yl)ethanone","C000620287","3_KE",870,3,"Cell Proliferation","Increase",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J707,K707)","v":"Cell Proliferation"},"D049109","Cell Proliferation",1,2,2016,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q707,Q707)","v":"27682507"},"Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300.","27682507",136]
["(S)-1-(5-hydroxy-1,5-dimethylhexyl)-3-(7-(4-methoxyphenyl)-(1,2,4-triazolo(1,5-a)pyrimidin-2-yl))urea","(S)-1-(5-hydroxy-1,5-dimethylhexyl)-3-(7-(4-methoxyphenyl)-(1,2,4-triazolo(1,5-a)pyrimidin-2-yl))urea","C509974","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2007,"17700168","A novel chemical compound, NK026680, targets dendritic cells to prolong recipient survival after rat liver grafting.","17700168",136]
["(S)-2-(3,4-dimethoxyphenyl)-1-(5-methoxy-2,2-dimethyl-2H-chromen-6-yl)propan-1-one","(S)-2-(3,4-dimethoxyphenyl)-1-(5-methoxy-2,2-dimethyl-2H-chromen-6-yl)propan-1-one","C578797","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"23186287","Design, synthesis, and biological evaluation of novel deguelin-based heat shock protein 90 (HSP90) inhibitors targeting proliferation and angiogenesis.","23186287",136]
["(S)-2-(benzylideneamino)-3-hydroxy-N-tetrade-cylpropanamide","(S)-2-(benzylideneamino)-3-hydroxy-N-tetrade-cylpropanamide","C573361","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22366655","Anti-proliferative effects of the novel ceramide analog (S)-2-(benzylideneamino)-3-hydroxy-N-tetrade-cylpropanamide in chemoresistant cancer.","22366655",136]
["(S)-2-(benzylideneamino)-3-hydroxy-N-tetrade-cylpropanamide","(S)-2-(benzylideneamino)-3-hydroxy-N-tetrade-cylpropanamide","C573361","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22366655","Anti-proliferative effects of the novel ceramide analog (S)-2-(benzylideneamino)-3-hydroxy-N-tetrade-cylpropanamide in chemoresistant cancer.","22366655",136]
["(S)-2,3-dihydrobenzo(b)furan-3-carboxylic acid","(S)-2,3-dihydrobenzo(b)furan-3-carboxylic acid","C576845","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"22829350","Dynamic kinetic resolution of 2,3-dihydrobenzo[b]furans: chemoenzymatic synthesis of analgesic agent BRL 37959.","22829350",136]
["(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one","(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one","C470586","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2002,"12212772","AF150(S) and AF267B: M1 muscarinic agonists as innovative therapies for Alzheimer's disease.","12212772",136]
["(S)-4-amino-4,5-dihydro-2-thiophenecarboxylic acid","(S)-4-amino-4,5-dihydro-2-thiophenecarboxylic acid","C524002","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"17713924","Inactivation of Escherichia coli L-aspartate aminotransferase by (S)-4-amino-4,5-dihydro-2-thiophenecarboxylic acid reveals \"a tale of two mechanisms\".","17713924",136]
["(S)-4-tert-butyldimethylsilyloxy-2-cyclopenten-1-one","(S)-4-tert-butyldimethylsilyloxy-2-cyclopenten-1-one","C486212","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2006,"16908599","Induction of apoptosis in estrogen receptor-negative breast cancer cells by natural and synthetic cyclopentenones: role of the IkappaB kinase/nuclear factor-kappaB pathway.","16908599",136]
["(S)-5-chloro-2,3-dihydrobenzo(b)furan-3-carboxylic acid","(S)-5-chloro-2,3-dihydrobenzo(b)furan-3-carboxylic acid","C576846","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"22829350","Dynamic kinetic resolution of 2,3-dihydrobenzo[b]furans: chemoenzymatic synthesis of analgesic agent BRL 37959.","22829350",136]
["(S)-chloro-1-(2-thienyl)-1-propanol","(S)-chloro-1-(2-thienyl)-1-propanol","C581188","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2012,"23070716","Synthesis of duloxetine intermediate (S)-3-Chloro-1-(2-thienyl)-1-propanol with liquid-core immobilized Candida pseudotropicalis 104.","23070716",136]
["(S)-chloro-1-(2-thienyl)-1-propanol","(S)-chloro-1-(2-thienyl)-1-propanol","C581188","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"23070716","Synthesis of duloxetine intermediate (S)-3-Chloro-1-(2-thienyl)-1-propanol with liquid-core immobilized Candida pseudotropicalis 104.","23070716",136]
["(S)-trans-gamma-monocyclofarnesol","(S)-trans-gamma-monocyclofarnesol","C578736","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"23413552","A practical, enantiospecific synthesis of (S)-trans-gamma-monocyclofarnesol.","23413552",136]
["(S,S)-ethylenediaminedisuccinate","(S,S)-ethylenediaminedisuccinate","C499100","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"17431801","Mobilization of heavy metals from contaminated paddy soil by EDDS, EDTA, and elemental sulfur.","17431801",136]
["(S,S)-ethylenediaminedisuccinate","(S,S)-ethylenediaminedisuccinate","C499100","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2010,"20207072","Influence of EDDS-to-metal molar ratio, solution pH, and soil-to-solution ratio on metal extraction under EDDS deficiency.","20207072",136]
["(S,S)-ethylenediaminedisuccinate","(S,S)-ethylenediaminedisuccinate","C499100","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"23534233","Extraction of heavy metals from e-waste contaminated soils using EDDS.","23534233",136]
["(S,S)-ethylenediaminedisuccinate","(S,S)-ethylenediaminedisuccinate","C499100","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2016,"27306211","Fast removal of tetracycline from wastewater by reduced graphene oxide prepared via microwave-assisted ethylenediamine-N,N'-disuccinic acid induction method.","27306211",136]
["(Z)-2-(6-(thieanisyl-2-yl)hexa-3-en-1,5-diynyl)benzenamine","(Z)-2-(6-(thieanisyl-2-yl)hexa-3-en-1,5-diynyl)benzenamine","C518618","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2007,"17064874","Induction of G2/M phase arrest and apoptosis by a novel enediyne derivative, THDB, in chronic myeloid leukemia (HL-60) cells.","17064874",136]
["(Z)-2-(6-(thieanisyl-2-yl)hexa-3-en-1,5-diynyl)benzenamine","(Z)-2-(6-(thieanisyl-2-yl)hexa-3-en-1,5-diynyl)benzenamine","C518618","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2007,"17064874","Induction of G2/M phase arrest and apoptosis by a novel enediyne derivative, THDB, in chronic myeloid leukemia (HL-60) cells.","17064874",136]
["(Z)-2-amino-5-chlorobenzophenonamidinohydrazone acetate","(Z)-2-amino-5-chlorobenzophenonamidinohydrazone acetate","C080444","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1993,"8460174","[Antiarrhythmia active amidinohydrazone substituted benzophenones. 5. The stability of (Z)-2-amino-5-chlorobenzophenone amidinohydrazone acetate in solution].","8460174",136]
["(Z)-3,4,3',5'-tetramethoxystilbene","(Z)-3,4,3',5'-tetramethoxystilbene","C582758","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"28169237","(Z)-3,4,3',5'-tetramethoxystilbene, a natural product, induces apoptosis and reduces viability of paclitaxel-and cisplatin-resistant osteosarcoma cells.","28169237",136]
["(Z)-3,4,3',5'-tetramethoxystilbene","(Z)-3,4,3',5'-tetramethoxystilbene","C582758","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"28169237","(Z)-3,4,3',5'-tetramethoxystilbene, a natural product, induces apoptosis and reduces viability of paclitaxel-and cisplatin-resistant osteosarcoma cells.","28169237",136]
["(Z)-7-acetoxy-methyl-11-methyl-3-methylene-dodeca-1,6,10-triene","(Z)-7-acetoxy-methyl-11-methyl-3-methylene-dodeca-1,6,10-triene","C556213","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"20362422","Inhibition of tumor cell proliferation and induction of apoptosis in human lung carcinoma 95-D cells by a new sesquiterpene from hairy root cultures of Artemisia annua.","20362422",136]
["(Z)-7-acetoxy-methyl-11-methyl-3-methylene-dodeca-1,6,10-triene","(Z)-7-acetoxy-methyl-11-methyl-3-methylene-dodeca-1,6,10-triene","C556213","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20362422","Inhibition of tumor cell proliferation and induction of apoptosis in human lung carcinoma 95-D cells by a new sesquiterpene from hairy root cultures of Artemisia annua.","20362422",136]
["027075 compound","027075 compound","C000620092","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"26773200","D5 receptor agonist 027075 promotes cognitive function recovery and neurogenesis in a Aβ1-42-induced mouse model.","26773200",136]
["1 alpha-(hydroxymethyl)-25-hydroxyvitamin D3","1 alpha-(hydroxymethyl)-25-hydroxyvitamin D3","C076210","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2017,"28025137","Nongenomic effects of 1α,25-dihydroxyvitamin D3 on cartilage formation deduced from comparisons between Cyp27b1 and Vdr knockout mice.","28025137",136]
["1 alpha,24-dihydroxyvitamin D3","1 alpha,24-dihydroxyvitamin D3","C023850","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,1999,"10228627","Proliferation is the main epidermal target in the treatment of psoriatic plaques with once daily application of tacalcitol ointment.","10228627",136]
["1 alpha,24-dihydroxyvitamin D3","1 alpha,24-dihydroxyvitamin D3","C023850","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2007,"18306931","The effect of combined treatment on head and neck human cancer cell lines with novel analogs of calcitriol and cytostatics.","18306931",136]
["1 alpha,24-dihydroxyvitamin D3","1 alpha,24-dihydroxyvitamin D3","C023850","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2008,"18813838","The influence of 1,25-dihydroxyvitamin D3 and 1,24-dihydroxyvitamin D3 on alphavbeta3 integrin expression in cancer cell lines.","18813838",136]
["1 alpha,24-dihydroxyvitamin D3","1 alpha,24-dihydroxyvitamin D3","C023850","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2009,"19503845","Influence of vitamin D(3) analogues in combination with budesonid R on proliferation of nasal polyp fibroblasts.","19503845",136]
["1 alpha,24-dihydroxyvitamin D3","1 alpha,24-dihydroxyvitamin D3","C023850","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"21934605","The in-vitro antiproliferative effect of PRI-2191 and imatinib applied in combined treatment with cisplatin, idarubicin, or docetaxel on human leukemia cells.","21934605",136]
["1 alpha,24-dihydroxyvitamin D3","1 alpha,24-dihydroxyvitamin D3","C023850","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2005,"15781040","Effects of PRI-2191--a low-calcemic analog of 1,25-dihydroxyvitamin D3 on the seizure-induced changes in brain gene expression and immune system activity in the rat.","15781040",136]
["1 alpha,24-dihydroxyvitamin D3","1 alpha,24-dihydroxyvitamin D3","C023850","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2005,"16158969","Correlation between VDR expression and antiproliferative activity of vitamin D3 compounds in combination with cytostatics.","16158969",136]
["1 alpha,24-dihydroxyvitamin D3","1 alpha,24-dihydroxyvitamin D3","C023850","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2007,"18551997","[The change of proliferative potential of fibroblasts derived of nasal polyps in vitro cultured, influenced by derivatives vitamins D].","18551997",136]
["1 alpha,24-dihydroxyvitamin D3","1 alpha,24-dihydroxyvitamin D3","C023850","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2008,"18813838","The influence of 1,25-dihydroxyvitamin D3 and 1,24-dihydroxyvitamin D3 on alphavbeta3 integrin expression in cancer cell lines.","18813838",136]
["1 alpha,24-dihydroxyvitamin D3","1 alpha,24-dihydroxyvitamin D3","C023850","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"19503845","Influence of vitamin D(3) analogues in combination with budesonid R on proliferation of nasal polyp fibroblasts.","19503845",136]
["1 alpha,24-dihydroxyvitamin D3","1 alpha,24-dihydroxyvitamin D3","C023850","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21070203","Vitamin D: a novel therapeutic approach for keloid, an in vitro analysis.","21070203",136]
["1 alpha,24-dihydroxyvitamin D3","1 alpha,24-dihydroxyvitamin D3","C023850","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"21934605","The in-vitro antiproliferative effect of PRI-2191 and imatinib applied in combined treatment with cisplatin, idarubicin, or docetaxel on human leukemia cells.","21934605",136]
["1 alpha,24-dihydroxyvitamin D3","1 alpha,24-dihydroxyvitamin D3","C023850","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Nasal Mucosa","D009297","Nasal Mucosa",1,1,2009,"19503845","Influence of vitamin D(3) analogues in combination with budesonid R on proliferation of nasal polyp fibroblasts.","19503845",136]
["1 alpha,24-dihydroxyvitamin D3","1 alpha,24-dihydroxyvitamin D3","C023850","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2018,"29115583","Unfavorable effect of calcitriol and its low-calcemic analogs on metastasis of 4T1 mouse mammary gland cancer.","29115583",136]
["1 alpha,24-dihydroxyvitamin D3","1 alpha,24-dihydroxyvitamin D3","C023850","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2016,"26511971","Differential interference of vitamin D analogs PRI-1906, PRI-2191, and PRI-2205 with the renewal of human colon cancer cells refractory to treatment with 5-fluorouracil.","26511971",136]
["1 alpha-hydroxyergocalciferol","1 alpha-hydroxyergocalciferol","C042533","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28586017","KML001 and doxercalciferol induce synergistic antileukemic effect in acute lymphoid leukemia cells.","28586017",136]
["1 alpha-hydroxyergocalciferol","1 alpha-hydroxyergocalciferol","C042533","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28586017","KML001 and doxercalciferol induce synergistic antileukemic effect in acute lymphoid leukemia cells.","28586017",136]
["1-(((3-hydroxy-1-adamantyl)amino)acetyl)-2-cyanopyrrolidine","1-(((3-hydroxy-1-adamantyl)amino)acetyl)-2-cyanopyrrolidine","C475520","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22474415","The synergistic effect of valsartan and LAF237 [(S)-1-[(3-hydroxy-1-adamantyl)ammo]acetyl-2-cyanopyrrolidine] on vascular oxidative stress and inflammation in type 2 diabetic mice.","22474415",136]
["1-((1-methyl-5-(2-(4-(2-(1-methylethoxy)phenyl)-1-piperazinyl)ethyl)-1H-pyrrol-2-yl)methyl)-2-piperidone","1-((1-methyl-5-(2-(4-(2-(1-methylethoxy)phenyl)-1-piperazinyl)ethyl)-1H-pyrrol-2-yl)methyl)-2-piperidone","C096245","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1995,"7473547","Piperazinylalkyl heterocycles as potential antipsychotic agents.","7473547",136]
["1-((1-O-octadecyl-2-O-methylglycero)phospho)-3-deoxy-myo-inositol","1-((1-O-octadecyl-2-O-methylglycero)phospho)-3-deoxy-myo-inositol","C435044","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2008,"18606397","SH-5, an AKT inhibitor potentiates apoptosis and inhibits invasion through the suppression of anti-apoptotic, proliferative and metastatic gene products regulated by IkappaBalpha kinase activation.","18606397",136]
["1-((1-O-octadecyl-2-O-methylglycero)phospho)-3-deoxy-myo-inositol","1-((1-O-octadecyl-2-O-methylglycero)phospho)-3-deoxy-myo-inositol","C435044","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"20546605","Characterization of AKT independent effects of the synthetic AKT inhibitors SH-5 and SH-6 using an integrated approach combining transcriptomic profiling and signaling pathway perturbations.","20546605",136]
["1-((1-O-octadecyl-2-O-methylglycero)phospho)-3-deoxy-myo-inositol","1-((1-O-octadecyl-2-O-methylglycero)phospho)-3-deoxy-myo-inositol","C435044","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2008,"18606397","SH-5, an AKT inhibitor potentiates apoptosis and inhibits invasion through the suppression of anti-apoptotic, proliferative and metastatic gene products regulated by IkappaBalpha kinase activation.","18606397",136]
["1-((2-(acetylamino)-2-carboxyethyl)thio)-2-amino-3-oxo-8-carboxyl-3H-phenoxiazine","1-((2-(acetylamino)-2-carboxyethyl)thio)-2-amino-3-oxo-8-carboxyl-3H-phenoxiazine","C485864","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2006,"16282322","A novel o-aminophenol oxidase responsible for formation of the phenoxazinone chromophore of grixazone.","16282322",136]
["1-((2-(acetylamino)-2-carboxyethyl)thio)-2-amino-3-oxo-8-formyl-3H-phenoxiazine","1-((2-(acetylamino)-2-carboxyethyl)thio)-2-amino-3-oxo-8-formyl-3H-phenoxiazine","C485863","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2006,"16282322","A novel o-aminophenol oxidase responsible for formation of the phenoxazinone chromophore of grixazone.","16282322",136]
["1-((2-adamantyl)amino)acetyl-2-cyano-(S)-pyrrolidine, monohydrochloride","1-((2-adamantyl)amino)acetyl-2-cyano-(S)-pyrrolidine, monohydrochloride","C569631","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22015634","A novel long acting DPP-IV inhibitor PKF-275-055 stimulates β-cell proliferation resulting in improved glucose homeostasis in diabetic rats.","22015634",136]
["1-((2-chloro-6-fluorobenzylidene)amino)-3-((5-methyl-2-oxo-2,3-dihydro-1H-indol-3-ylidene)amino)thiourea","1-((2-chloro-6-fluorobenzylidene)amino)-3-((5-methyl-2-oxo-2,3-dihydro-1H-indol-3-ylidene)amino)thiourea","C000616831","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28147307","Isatin-β-thiocarbohydrazones: Microwave-assisted synthesis, antitumor activity and structure-activity relationship.","28147307",136]
["1-((2-chloro-6-fluorobenzylidene)amino)-3-((5-methyl-2-oxo-2,3-dihydro-1H-indol-3-ylidene)amino)thiourea","1-((2-chloro-6-fluorobenzylidene)amino)-3-((5-methyl-2-oxo-2,3-dihydro-1H-indol-3-ylidene)amino)thiourea","C000616831","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28147307","Isatin-β-thiocarbohydrazones: Microwave-assisted synthesis, antitumor activity and structure-activity relationship.","28147307",136]
["1-((2-di-p-tolylbismuthanophenyl)diazenyl)pyrrolidine","1-((2-di-p-tolylbismuthanophenyl)diazenyl)pyrrolidine","C583560","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2012,"23078777","A novel organobismuth compound, 1-[(2-di-p-tolylbismuthanophenyl)diazenyl]pyrrolidine, induces apoptosis in the human acute promyelocytic leukemia cell line NB4 via reactive oxygen species.","23078777",136]
["1-((2-hydroxyethoxy)methyl)-6-(phenylthio)thymine","1-((2-hydroxyethoxy)methyl)-6-(phenylthio)thymine","C061818","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2006,"16946529","Non-nucleoside HIV-1 reverse transcriptase inhibitors, Part 7. Synthesis, antiviral activity, and 3D-QSAR investigations of novel 6-(1-naphthoyl) HEPT analogues.","16946529",136]
["1-((2-hydroxyethyl)amino)-2-amino-1,2-dideoxyglucose triphenyltin(IV)","1-((2-hydroxyethyl)amino)-2-amino-1,2-dideoxyglucose triphenyltin(IV)","C574212","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22183270","Design, synthesis, characterization and DNA-binding studies of a triphenyltin(IV) complex of N-glycoside (GATPT), a sugar based apoptosis inducer: in vitro and in vivo assessment of induction of apoptosis by GATPT.","22183270",136]
["1-((2-hydroxyethyl)amino)-4-methyl-9H-thioxanthen-9-one","1-((2-hydroxyethyl)amino)-4-methyl-9H-thioxanthen-9-one","C550714","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2010,"20362393","Preparation of a new chromium(III) selective electrode based on 1-[(2-hydroxy ethyl) amino]-4-methyl-9H-thioxanthen-9-one as a neutral carrier.","20362393",136]
["1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone","1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone","C053433","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2001,"11399264","Caspase-independent apoptosis induced by differentiation-inducing factor of Dicytostelium discoideum in INS-1 cells.","11399264",136]
["1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone","1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone","C053433","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27027430","Differentiation inducing factor 3 mediates its anti-leukemic effect through ROS-dependent DRP1-mediated mitochondrial fission and induction of caspase-independent cell death.","27027430",136]
["1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone","1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone","C053433","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2008,"18977198","Biological activities of novel derivatives of DIF-1 isolated from Dictyostelium.","18977198",136]
["1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone","1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone","C053433","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25913757","Differentiation-inducing factor-3 inhibits intestinal tumor growth in vitro and in vivo.","25913757",136]
["1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone","1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone","C053433","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"26056940","Derivatives of Dictyostelium differentiation-inducing factors inhibit lysophosphatidic acid-stimulated migration of murine osteosarcoma LM8 cells.","26056940",136]
["1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone","1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone","C053433","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27027430","Differentiation inducing factor 3 mediates its anti-leukemic effect through ROS-dependent DRP1-mediated mitochondrial fission and induction of caspase-independent cell death.","27027430",136]
["1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone","1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone","C053433","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"29093342","Biological Activities of Novel Derivatives of Differentiation-Inducing Factor 3 from Dictyostelium discoideum.","29093342",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C771,B771)","v":"1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone"},"1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone","C053433","1_MIE",867,1,"Intracellular pH","Decrease",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J771,K771)","v":"Hydrogen-Ion Concentration"},"D006863","Hydrogen-Ion Concentration",2,2,1992,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q771,Q771)","v":"1521542"},"Differentiation-inducing-factor dechlorinase, a novel cytosolic dechlorinating enzyme from Dictyostelium discoideum.","1521542",136]
["1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone","1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone","C053433","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1989,"2466719","Studies on the accumulation of the differentiation-inducing factor (DIF) in high-cell-density monolayers of Dictyostelium discoideum.","2466719",136]
["1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone","1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone","C053433","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,1,2001,"11336701","Tyrosine phosphorylation-independent nuclear translocation of a dictyostelium STAT in response to DIF signaling.","11336701",136]
["1-((3-chloromethyl)phenyl)-3-prop-2-ynylurea","1-((3-chloromethyl)phenyl)-3-prop-2-ynylurea","C574963","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22414612","Synthesis and evaluation of 1-(substituted)-3-prop-2-ynylureas as antiangiogenic agents.","22414612",136]
["1-((3-chlorophenyl)methyl)-1H-indole-3-carbinol","1-((3-chlorophenyl)methyl)-1H-indole-3-carbinol","C000595256","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"22174819","Antitumor activity of a novel oncrasin analogue is mediated by JNK activation and STAT3 inhibition.","22174819",136]
["1-((3-chlorophenyl)methyl)-1H-indole-3-carbinol","1-((3-chlorophenyl)methyl)-1H-indole-3-carbinol","C000595256","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"25182964","Prodrug oncrasin-266 improves the stability, pharmacokinetics, and safety of NSC-743380.","25182964",136]
["1-((4,5-bis(4-methoxyphenyl)-2-thiazoyl)carbonyl)-4-methylpiperazine","1-((4,5-bis(4-methoxyphenyl)-2-thiazoyl)carbonyl)-4-methylpiperazine","C085131","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"20596620","Induction of cell growth arrest and apoptotic cell death in human breast cancer MCF-7 cells by the COX-1 inhibitor FR122047.","20596620",136]
["1-((4,5-bis(4-methoxyphenyl)-2-thiazoyl)carbonyl)-4-methylpiperazine","1-((4,5-bis(4-methoxyphenyl)-2-thiazoyl)carbonyl)-4-methylpiperazine","C085131","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20596620","Induction of cell growth arrest and apoptotic cell death in human breast cancer MCF-7 cells by the COX-1 inhibitor FR122047.","20596620",136]
["1-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride","1-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride","C092824","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1997,"9503258","Atypical in vitro and in vivo binding of [3H]S-14506 to brain 5-HT1A receptors.","9503258",136]
["1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole","1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole","C090859","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2001,"11687954","A cyclooxygenase-2 inhibitor (SC-58125) blocks growth of established human colon cancer xenografts.","11687954",136]
["1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole","1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole","C090859","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2005,"16116973","Inhibitory effects of Celecoxib and Sc-58125 on proliferation of human carcinoma of larynx Hep-2 in vitro.","16116973",136]
["1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole","1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole","C090859","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2007,"17430655","[Effects of selective cyclooxygenase-2 inhibitor on proliferation and apoptosis of human bladder cancer cell line T24].","17430655",136]
["1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole","1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole","C090859","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2005,"16116973","Inhibitory effects of Celecoxib and Sc-58125 on proliferation of human carcinoma of larynx Hep-2 in vitro.","16116973",136]
["1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole","1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole","C090859","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2007,"17430655","[Effects of selective cyclooxygenase-2 inhibitor on proliferation and apoptosis of human bladder cancer cell line T24].","17430655",136]
["1-((5-((4-(2-methoxyphenyl)-1-piperazinyl)methyl)-2-furanyl)methyl)-2-azepinone","1-((5-((4-(2-methoxyphenyl)-1-piperazinyl)methyl)-2-furanyl)methyl)-2-azepinone","C096246","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1995,"7473547","Piperazinylalkyl heterocycles as potential antipsychotic agents.","7473547",136]
["1-((5-((4-(2-methoxy-phenyl)-1-piperazinyl)methyl)-2-furanyl)methyl)-2-azocinone","1-((5-((4-(2-methoxy-phenyl)-1-piperazinyl)methyl)-2-furanyl)methyl)-2-azocinone","C096247","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1995,"7473547","Piperazinylalkyl heterocycles as potential antipsychotic agents.","7473547",136]
["1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine","1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine","C484309","3_KE",870,3,"Cell Proliferation","Increase","Airway Remodeling","D056151","Airway Remodeling",2,3,2010,"20573261","Histamine H4 receptor antagonism diminishes existing airway inflammation and dysfunction via modulation of Th2 cytokines.","20573261",136]
["1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine","1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine","C484309","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"23978101","Effects of a selective histamine H₄R antagonist on inflammation in a model of carrageenan-induced pleurisy in the rat.","23978101",136]
["1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine","1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine","C484309","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"26919586","Pharmacological targeting of histamine H4 receptor in periodontal disease.","26919586",136]
["1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine","1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine","C484309","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23922686","Protection of radiation-induced damage to the hematopoietic system, small intestine and salivary glands in rats by JNJ7777120 compound, a histamine H4 ligand.","23922686",136]
["1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine","1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine","C484309","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"26931395","The Synthesis of 1,3,5-triazine Derivatives and JNJ7777120 Analogues with Histamine H4 Receptor Affinity and Their Interaction with PTEN Promoter.","26931395",136]
["1-(1-(3,4,5-trimethoxyphenyl)vinyl)-1H-indol-4-amine","1-(1-(3,4,5-trimethoxyphenyl)vinyl)-1H-indol-4-amine","C000595116","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"25029590","Tandem one-pot palladium-catalyzed coupling of hydrazones, haloindoles, and amines: synthesis of amino-N-vinylindoles and their effect on human colon carcinoma cells.","25029590",136]
["1-(1-(imidazo(1,2-a)pyridin-6-yl)ethyl)-6-(1-methyl-1H-pyrazol-4-yl)-1H-(1,2,3)triazolo(4,5-b)pyrazine","1-(1-(imidazo(1,2-a)pyridin-6-yl)ethyl)-6-(1-methyl-1H-pyrazol-4-yl)-1H-(1,2,3)triazolo(4,5-b)pyrazine","C000593259","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"25148209","Discovery of (S)-1-(1-(Imidazo[1,2-a]pyridin-6-yl)ethyl)-6-(1-methyl-1H-pyrazol-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazine (volitinib) as a highly potent and selective mesenchymal-epithelial transition factor (c-Met) inhibitor in clinical development for treatment of cancer.","25148209",136]
["1-(1,3-carboxypropyl)-4,7-carboxymethyl-1,4,7-triazacyclononane","1-(1,3-carboxypropyl)-4,7-carboxymethyl-1,4,7-triazacyclononane","C572723","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2014,"24417983","Comparison of two new angiogenesis PET tracers 68Ga-NODAGA-E[c(RGDyK)]2 and (64)Cu-NODAGA-E[c(RGDyK)]2; in vivo imaging studies in human xenograft tumors.","24417983",136]
["1-(1,3-carboxypropyl)-4,7-carboxymethyl-1,4,7-triazacyclononane","1-(1,3-carboxypropyl)-4,7-carboxymethyl-1,4,7-triazacyclononane","C572723","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2015,"25945808","First-In-Human Study Demonstrating Tumor-Angiogenesis by PET/CT Imaging with (68)Ga-NODAGA-THERANOST, a High-Affinity Peptidomimetic for αvβ3 Integrin Receptor Targeting.","25945808",136]
["1-(1,3-carboxypropyl)-4,7-carboxymethyl-1,4,7-triazacyclononane","1-(1,3-carboxypropyl)-4,7-carboxymethyl-1,4,7-triazacyclononane","C572723","7_AO",872,7,"Site of Contact Nasal Tumors","Increase","Nose","D009666","Nose",1,1,2016,"26795701","Visualization and Quantitative Assessment of the Brain Distribution of Insulin through Nose-to-Brain Delivery Based on the Cell-Penetrating Peptide Noncovalent Strategy.","26795701",136]
["1-(1,4-benzodioxan-6-ylcarbonyl)piperidine","1-(1,4-benzodioxan-6-ylcarbonyl)piperidine","C443080","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22506985","Ampakine CX546 increases proliferation and neuronal differentiation in subventricular zone stem/progenitor cell cultures.","22506985",136]
["1-(1,4-dihydro-5,8-dihydroxy-1,4-dioxonaphthalen-2-yl)-4-methylpent-3-enylfuran-2-caroxylate","1-(1,4-dihydro-5,8-dihydroxy-1,4-dioxonaphthalen-2-yl)-4-methylpent-3-enylfuran-2-caroxylate","C512540","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2006,"16570288","SH-7, a new synthesized shikonin derivative, exerting its potent antitumor activities as a topoisomerase inhibitor.","16570288",136]
["1-(1,4-dihydro-5,8-dihydroxy-1,4-dioxonaphthalen-2-yl)-4-methylpent-3-enylfuran-2-caroxylate","1-(1,4-dihydro-5,8-dihydroxy-1,4-dioxonaphthalen-2-yl)-4-methylpent-3-enylfuran-2-caroxylate","C512540","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2006,"16570288","SH-7, a new synthesized shikonin derivative, exerting its potent antitumor activities as a topoisomerase inhibitor.","16570288",136]
["1-(10-pyrenedecanoyl)-2,3-dioleoylglycerol","1-(10-pyrenedecanoyl)-2,3-dioleoylglycerol","C046439","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1988,"3172990","Use of a fluorescent radiolabeled triacylglycerol as a substrate for lipoprotein lipase and hepatic triglyceride lipase.","3172990",136]
["1-(13-hydroperoxy-9,11-octadecadienoyl)glycerol","1-(13-hydroperoxy-9,11-octadecadienoyl)glycerol","C426011","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2001,"11295443","Enzyme-catalyzed and enzyme-triggered pathways in dioxygenation of 1-monolinoleoyl-rac-glycerol by potato tuber lipoxygenase.","11295443",136]
["1-(1-acryloylpyrrolidin-3-yl)-7-(3-methyl-4-(4-methylpiperazin-1-yl)phenylamino)-3-phenyl-3,4-dihydropyrimido(4,5-d)pyrimidin-2(1H)-one","1-(1-acryloylpyrrolidin-3-yl)-7-(3-methyl-4-(4-methylpiperazin-1-yl)phenylamino)-3-phenyl-3,4-dihydropyrimido(4,5-d)pyrimidin-2(1H)-one","C587007","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"24124898","Design, synthesis, and biological evaluation of 2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidinyl derivatives as new irreversible epidermal growth factor receptor inhibitors with improved pharmacokinetic properties.","24124898",136]
["1-(1-butyl)-4-(2-oxo-1-benzimidazolinyl)piperidine","1-(1-butyl)-4-(2-oxo-1-benzimidazolinyl)piperidine","C120154","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2013,"23926946","ExoSensor 517: a dual-analyte fluorescent chemosensor for visualizing neurotransmitter exocytosis.","23926946",136]
["1-(1-carboxymethyl)-3-(2-hydroxypropyl)pyridinium betaine","1-(1-carboxymethyl)-3-(2-hydroxypropyl)pyridinium betaine","C058440","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1988,"2975196","Formation of a pyridinium derivative by reaction of 4-hydroxypentenal with glycine.","2975196",136]
["1-(1H-1,2,4-triazole)-2-(2,4-diflurophenyl)-3-(N-methyl-N-(4-iodo-benzyl)amino)-2-propanol","1-(1H-1,2,4-triazole)-2-(2,4-diflurophenyl)-3-(N-methyl-N-(4-iodo-benzyl)amino)-2-propanol","C518326","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"16950589","High performance liquid chromatographic determination of a new antifungal compound, ADKZ in rat plasma.","16950589",136]
["1-(1H-indol-3-yl)-3-(3H-indol-3-ylidene)propan-2-one","1-(1H-indol-3-yl)-3-(3H-indol-3-ylidene)propan-2-one","C547593","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2009,"19860413","Structural identification of Diindole agonists of the aryl hydrocarbon receptor derived from degradation of indole-3-pyruvic acid.","19860413",136]
["1-(1-hydroxy-5-isoquinolinesulfonyl)homopiperazine","1-(1-hydroxy-5-isoquinolinesulfonyl)homopiperazine","C110851","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,1998,"9498817","Inhibition of HIV-1 Nef-induced apoptosis of uninfected human blood cells by serine/threonine protein kinase inhibitors, fasudil hydrochloride and M3.","9498817",136]
["1-(1-hydroxy-6,6,9-trimethyl-6a,7,8,9,10,10a-hexahydro-6H-benzo(c)chromen-2-yl)ethanone","1-(1-hydroxy-6,6,9-trimethyl-6a,7,8,9,10,10a-hexahydro-6H-benzo(c)chromen-2-yl)ethanone","C575739","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"20230799","Induction of p53-independent apoptosis by a novel synthetic hexahydrocannabinol analog is mediated via Sp1-dependent NSAID-activated gene-1 in colon cancer cells.","20230799",136]
["1-(1-hydroxy-6,6,9-trimethyl-6a,7,8,9,10,10a-hexahydro-6H-benzo(c)chromen-2-yl)ethanone","1-(1-hydroxy-6,6,9-trimethyl-6a,7,8,9,10,10a-hexahydro-6H-benzo(c)chromen-2-yl)ethanone","C575739","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2012,"22687485","Anti-tumor activity of the novel hexahydrocannabinol analog LYR-8 in Human colorectal tumor xenograft is mediated through the inhibition of Akt and hypoxia-inducible factor-1α activation.","22687485",136]
["1-(1'-naphthyl)ethanol","1-(1'-naphthyl)ethanol","C521161","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"17027259","Improvement of carbonyl reductase production of Geotrichum candidum for the transformation of 1-acetonaphthone to S(-)-1-(1'-napthyl) ethanol.","17027259",136]
["1-(1'-naphthyl)ethanol","1-(1'-naphthyl)ethanol","C521161","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2016,"27581384","Preparation of Enantiomerically Pure (S)-(-)-1-(1'-naphthyl)-ethanol by the Fungus Alternaria alternata.","27581384",136]
["1-(1'-naphthyl)ethanol","1-(1'-naphthyl)ethanol","C521161","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2017,"28671310","Resolution of enantiopure (S)-1-(1-napthyl) ethanol from racemic mixture by a novel Bacillus cereus isolate.","28671310",136]
["1-(1-naphthyl)ethylamine","1-(1-naphthyl)ethylamine","C055450","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"26140359","Neutral and ionic platinum compounds containing a cyclometallated chiral primary amine: synthesis, antitumor activity, DNA interaction and topoisomerase I-cathepsin B inhibition.","26140359",136]
["1-(1-naphthylmethyl)piperazine","1-(1-naphthylmethyl)piperazine","C511391","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2009,"19279048","Reduced susceptibility of multidrug-resistant Acinetobacter baumannii to tigecycline in combination with 1-(1-naphthylmethyl)-piperazine is not a pH-dependent phenomenon.","19279048",136]
["1-(2-((1H-indol-5-yl)oxy)ethyl)-4,4-dimethyl-6-(pyridin-3-yl)-1,2,3,4-tetrahydroquinoline","1-(2-((1H-indol-5-yl)oxy)ethyl)-4,4-dimethyl-6-(pyridin-3-yl)-1,2,3,4-tetrahydroquinoline","C000622280","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28654259","New Inhibitor Targeting Signal Transducer and Activator of Transcription 5 (STAT5) Signaling in Myeloid Leukemias.","28654259",136]
["1-(2-((3-(2-(1H-indol-3-yl)ethyl)-5-(propylthio)-3H-(1,2,3)triazolo(4,5-d)pyrimidin-7-yl)amino)ethyl)-3-(pyridin-3-yl)thiourea","1-(2-((3-(2-(1H-indol-3-yl)ethyl)-5-(propylthio)-3H-(1,2,3)triazolo(4,5-d)pyrimidin-7-yl)amino)ethyl)-3-(pyridin-3-yl)thiourea","C000623331","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28863355","Design, synthesis and preliminary biological evaluation of new [1,2,3]triazolo[4,5-d]pyrimidine/thiourea hybrids as antiproliferative agents.","28863355",136]
["1-(2-((3-(2-(1H-indol-3-yl)ethyl)-5-(propylthio)-3H-(1,2,3)triazolo(4,5-d)pyrimidin-7-yl)amino)ethyl)-3-(pyridin-3-yl)thiourea","1-(2-((3-(2-(1H-indol-3-yl)ethyl)-5-(propylthio)-3H-(1,2,3)triazolo(4,5-d)pyrimidin-7-yl)amino)ethyl)-3-(pyridin-3-yl)thiourea","C000623331","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28863355","Design, synthesis and preliminary biological evaluation of new [1,2,3]triazolo[4,5-d]pyrimidine/thiourea hybrids as antiproliferative agents.","28863355",136]
["1-(2-((Z)-6-(2-(trifluoromethyl)phenyl)hexa-3-en-1,5-diynyl)phenyl)piperidin-2-one","1-(2-((Z)-6-(2-(trifluoromethyl)phenyl)hexa-3-en-1,5-diynyl)phenyl)piperidin-2-one","C545767","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2009,"19818634","1-(2-((Z)-6-(2-(Trifluoromethyl)phenyl)hexa-3-en-1,5-diynyl)phenyl)piperidin-2-one as a new potent apoptosis agent.","19818634",136]
["1-(2-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)ethoxycarbonyloxymethyl)-4-(N'-cyano-N''-(6-(4-chlorophenoxy)hexyl)-N-guanidino)pyridinium","1-(2-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)ethoxycarbonyloxymethyl)-4-(N'-cyano-N''-(6-(4-chlorophenoxy)hexyl)-N-guanidino)pyridinium","C541789","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"20112275","Metronomic administration of the drug GMX1777, a cellular NAD synthesis inhibitor, results in neuroblastoma regression and vessel maturation without inducing drug resistance.","20112275",136]
["1-(2-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)ethoxycarbonyloxymethyl)-4-(N'-cyano-N''-(6-(4-chlorophenoxy)hexyl)-N-guanidino)pyridinium","1-(2-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)ethoxycarbonyloxymethyl)-4-(N'-cyano-N''-(6-(4-chlorophenoxy)hexyl)-N-guanidino)pyridinium","C541789","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2010,"20112275","Metronomic administration of the drug GMX1777, a cellular NAD synthesis inhibitor, results in neuroblastoma regression and vessel maturation without inducing drug resistance.","20112275",136]
["1-(2-(2-(4-pyridyl)-2-imidazoline-1-yl)ethyl)-3-(4-carboxyphenyl)urea","1-(2-(2-(4-pyridyl)-2-imidazoline-1-yl)ethyl)-3-(4-carboxyphenyl)urea","C033192","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Atrophy","D001284","Atrophy",1,2,1991,"1744161","Prostatic atrophy in dogs after intravenous administration of a ureido-ethylimidazoline derivative (CGP15'720A).","1744161",136]
["1-(2-(2,5-dimethoxyphenylthio)benzylidene)semicarbazide","1-(2-(2,5-dimethoxyphenylthio)benzylidene)semicarbazide","C541072","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2009,"19282188","Discovery and structure-activity relationships of (2-(arylthio)benzylideneamino)guanidines as a novel series of potent apoptosis inducers.","19282188",136]
["1-(2-(2-methoxyphenylamino)ethylamino)-3-(naphthalene-1-yloxy)propan-2-ol","1-(2-(2-methoxyphenylamino)ethylamino)-3-(naphthalene-1-yloxy)propan-2-ol","C586405","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24754309","Newly synthesized anticancer drug HUHS1015 is effective on malignant pleural mesothelioma.","24754309",136]
["1-(2-(2-methoxyphenylamino)ethylamino)-3-(naphthalene-1-yloxy)propan-2-ol","1-(2-(2-methoxyphenylamino)ethylamino)-3-(naphthalene-1-yloxy)propan-2-ol","C586405","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25244912","HUHS1015 induces necroptosis and caspase-independent apoptosis of MKN28 human gastric cancer cells in association with AMID accumulation in the nucleus.","25244912",136]
["1-(2-(2-methoxyphenylamino)ethylamino)-3-(naphthalene-1-yloxy)propan-2-ol","1-(2-(2-methoxyphenylamino)ethylamino)-3-(naphthalene-1-yloxy)propan-2-ol","C586405","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"25532843","1-[2-(2-Methoxyphenylamino)ethylamino]-3-(naphthalene-1- yloxy)propan-2-ol may be a promising anticancer drug.","25532843",136]
["1-(2-(2-methoxyphenylamino)ethylamino)-3-(naphthalene-1-yloxy)propan-2-ol","1-(2-(2-methoxyphenylamino)ethylamino)-3-(naphthalene-1-yloxy)propan-2-ol","C586405","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25567349","The newly synthesized anticancer drug HUHS1015 is useful for treatment of human gastric cancer.","25567349",136]
["1-(2-(2-methoxyphenylamino)ethylamino)-3-(naphthalene-1-yloxy)propan-2-ol","1-(2-(2-methoxyphenylamino)ethylamino)-3-(naphthalene-1-yloxy)propan-2-ol","C586405","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"26722026","HUHS1015 Suppresses Colonic Cancer Growth by Inducing Necrosis and Apoptosis in Association with Mitochondrial Damage.","26722026",136]
["1-(2-(2-methoxyphenylamino)ethylamino)-3-(naphthalene-1-yloxy)propan-2-ol","1-(2-(2-methoxyphenylamino)ethylamino)-3-(naphthalene-1-yloxy)propan-2-ol","C586405","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25567349","The newly synthesized anticancer drug HUHS1015 is useful for treatment of human gastric cancer.","25567349",136]
["1-(2-(2-methoxyphenylamino)ethylamino)-3-(naphthalene-1-yloxy)propan-2-ol","1-(2-(2-methoxyphenylamino)ethylamino)-3-(naphthalene-1-yloxy)propan-2-ol","C586405","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"26722026","HUHS1015 Suppresses Colonic Cancer Growth by Inducing Necrosis and Apoptosis in Association with Mitochondrial Damage.","26722026",136]
["1-(2-(2-methoxyphenylamino)ethylamino)-3-(naphthalene-1-yloxy)propan-2-ol","1-(2-(2-methoxyphenylamino)ethylamino)-3-(naphthalene-1-yloxy)propan-2-ol","C586405","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2014,"25532843","1-[2-(2-Methoxyphenylamino)ethylamino]-3-(naphthalene-1- yloxy)propan-2-ol may be a promising anticancer drug.","25532843",136]
["1-(2-(2-methoxyphenylamino)ethylamino)-3-(naphthalene-1-yloxy)propan-2-ol","1-(2-(2-methoxyphenylamino)ethylamino)-3-(naphthalene-1-yloxy)propan-2-ol","C586405","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,2,2015,"25244912","HUHS1015 induces necroptosis and caspase-independent apoptosis of MKN28 human gastric cancer cells in association with AMID accumulation in the nucleus.","25244912",136]
["1-(2-(2-methoxyphenylamino)ethylamino)-3-(naphthalene-1-yloxy)propan-2-ol","1-(2-(2-methoxyphenylamino)ethylamino)-3-(naphthalene-1-yloxy)propan-2-ol","C586405","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2016,"26722026","HUHS1015 Suppresses Colonic Cancer Growth by Inducing Necrosis and Apoptosis in Association with Mitochondrial Damage.","26722026",136]
["1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole","1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole","C063159","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2000,"10969777","Bcl-2 overexpression results in enhanced capacitative calcium entry and resistance to SKF-96365-induced apoptosis.","10969777",136]
["1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole","1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole","C063159","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"21767581","SK&amp;F 96365 induces apoptosis and autophagy by inhibiting Akt-mTOR signaling in A7r5 cells.","21767581",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C835,B835)","v":"1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole"},"1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole","C063159","5_KE",768,5,"Cytotoxicity","Increase",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J835,K835)","v":"Apoptosis"},"D017209","Apoptosis",1,2,2016,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q835,Q835)","v":"26803057"},"SKF-96365 activates cytoprotective autophagy to delay apoptosis in colorectal cancer cells through inhibition of the calcium/CaMKIIγ/AKT-mediated pathway.","26803057",136]
["1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole","1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole","C063159","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2006,"16539844","Interaction between Cl- channels and CRAC-related Ca2+ signaling during T lymphocyte activation and proliferation.","16539844",136]
["1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole","1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole","C063159","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21470712","The anti-inflammatory effect of the SOCC blocker SK&amp;F 96365 on mouse lymphocytes after stimulation by Con A or PMA/ionomycin.","21470712",136]
["1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole","1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole","C063159","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21767581","SK&amp;F 96365 induces apoptosis and autophagy by inhibiting Akt-mTOR signaling in A7r5 cells.","21767581",136]
["1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole","1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole","C063159","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23974726","Store-operated Ca2+ channels blockers inhibit lipopolysaccharide induced astrocyte activation.","23974726",136]
["1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole","1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole","C063159","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"26803057","SKF-96365 activates cytoprotective autophagy to delay apoptosis in colorectal cancer cells through inhibition of the calcium/CaMKIIγ/AKT-mediated pathway.","26803057",136]
["1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole","1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole","C063159","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28030826","Inhibition of TRPC6 reduces non-small cell lung cancer cell proliferation and invasion.","28030826",136]
["1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole","1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole","C063159","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2011,"21767581","SK&amp;F 96365 induces apoptosis and autophagy by inhibiting Akt-mTOR signaling in A7r5 cells.","21767581",136]
["1-(2-(3,4-dimethoxyphenyl)ethyl)-4-(3-(3-iodophenyl)propyl)piperazine","1-(2-(3,4-dimethoxyphenyl)ethyl)-4-(3-(3-iodophenyl)propyl)piperazine","C515064","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2008,"18451511","Evaluation of radioiodinated 1-[2-(3,4-Dimethoxyphenyl)ethyl]-4-(2-iodophenylpropyl)piperazine as a tumor diagnostic agent with functional sigma receptor imaging by single photon emission computed tomography.","18451511",136]
["1-(2-(4-benzyl-4-hydroxypiperidin-1-yl)ethyl)-3-(2-methylquinolin-4-yl)urea","1-(2-(4-benzyl-4-hydroxypiperidin-1-yl)ethyl)-3-(2-methylquinolin-4-yl)urea","C493249","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2005,"15710491","Effect of lesions of cerebellar fastigial nuclei on lymphocyte functions of rats.","15710491",136]
["1-(2-(acridin-9-ylamino)ethyl)-1,3-dimethylthiourea","1-(2-(acridin-9-ylamino)ethyl)-1,3-dimethylthiourea","C471910","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2005,"15895232","Platinum-acridinylthiourea conjugates show cell line-specific cytotoxic enhancement in H460 lung carcinoma cells compared to cisplatin.","15895232",136]
["1-(2-(acridin-9-ylamino)ethyl)-1,3-dimethylthiourea","1-(2-(acridin-9-ylamino)ethyl)-1,3-dimethylthiourea","C471910","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"19803526","Gold(I) analogues of a platinum-acridine antitumor agent are only moderately cytotoxic but show potent activity against Mycobacterium tuberculosis.","19803526",136]
["1-(2-(decylthio)ethyl)azacyclopentane-2-one","1-(2-(decylthio)ethyl)azacyclopentane-2-one","C075725","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Nasal Mucosa","D009297","Nasal Mucosa",1,2,2005,"15770076","Effectiveness of pirotiodecane, absorption enhancer, on nasal absorption in rabbits.","15770076",136]
["1-(2-(N-ethylamino)-5-fluorophenoxy)-2-(2-fluoro-4-aminophenoxy)ethane-N,N',N'-triacetic acid","1-(2-(N-ethylamino)-5-fluorophenoxy)-2-(2-fluoro-4-aminophenoxy)ethane-N,N',N'-triacetic acid","C093046","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1995,"7711108","Fluorinated o-aminophenol derivatives for measurement of intracellular pH.","7711108",136]
["1-(2, 4-dichlorophenyl)-4, 5-dihydro-5-methyl-1H-pyrazole-3,5-dicarboxylic acid diethyl ester","1-(2, 4-dichlorophenyl)-4, 5-dihydro-5-methyl-1H-pyrazole-3,5-dicarboxylic acid diethyl ester","C555731","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2010,"20835868","Hydrolysis of mefenpyrdiethyl: an analytical and DFT investigation.","20835868",136]
["1-(2, 4-dichlorophenyl)-4, 5-dihydro-5-methyl-1H-pyrazole-3,5-dicarboxylic acid diethyl ester","1-(2, 4-dichlorophenyl)-4, 5-dihydro-5-methyl-1H-pyrazole-3,5-dicarboxylic acid diethyl ester","C555731","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"23520878","Efficiency and degradation products elucidation of the photodegradation of mefenpyrdiethyl in water interface using TiO2 P-25 and Hombikat UV100.","23520878",136]
["1-(2',3',4',6'-tetraacetylglucopyranosyloxyl)-1,4a,5,7a-tetrahydro-7-(acetomethyl)-cyclopentapyran-4-caroboxylic acid methyl ester","1-(2',3',4',6'-tetraacetylglucopyranosyloxyl)-1,4a,5,7a-tetrahydro-7-(acetomethyl)-cyclopentapyran-4-caroboxylic acid methyl ester","C469218","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2002,"12385722","Induction of apoptosis by penta-acetyl geniposide in rat C6 glioma cells.","12385722",136]
["1-(2',3',4',6'-tetraacetylglucopyranosyloxyl)-1,4a,5,7a-tetrahydro-7-(acetomethyl)-cyclopentapyran-4-caroboxylic acid methyl ester","1-(2',3',4',6'-tetraacetylglucopyranosyloxyl)-1,4a,5,7a-tetrahydro-7-(acetomethyl)-cyclopentapyran-4-caroboxylic acid methyl ester","C469218","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2004,"15135084","Penta-acetyl geniposide-induced C6 glioma cell apoptosis was associated with the activation of protein kinase C-delta.","15135084",136]
["1-(2,3,4-trideoxy-2-methylene-beta-d-glycero-hex-3-enopyranosyl)thymine","1-(2,3,4-trideoxy-2-methylene-beta-d-glycero-hex-3-enopyranosyl)thymine","C522701","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2007,"17555969","Exomethylene pyranonucleosides: efficient synthesis and biological evaluation of 1-(2,3,4-trideoxy-2-methylene-beta-d-glycero-hex-3-enopyranosyl)thymine.","17555969",136]
["1-(2,3-dichloro-4-((3-(4-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)methoxy)phenyl)-2-methylenebutan-1-one","1-(2,3-dichloro-4-((3-(4-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)methoxy)phenyl)-2-methylenebutan-1-one","C587438","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23804706","Ethacrynic acid oxadiazole analogs induce apoptosis in malignant hematologic cells through downregulation of Mcl-1 and c-FLIP, which was attenuated by GSTP1-1.","23804706",136]
["1-(2,3-dichloro-4-((3-phenyl-1,2,4-oxadiazol-5-yl)methoxy)phenyl)-2-methylenebutan-1-one","1-(2,3-dichloro-4-((3-phenyl-1,2,4-oxadiazol-5-yl)methoxy)phenyl)-2-methylenebutan-1-one","C587437","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23804706","Ethacrynic acid oxadiazole analogs induce apoptosis in malignant hematologic cells through downregulation of Mcl-1 and c-FLIP, which was attenuated by GSTP1-1.","23804706",136]
["1-(2,3-dichlorobenzoyl)-5-methoxy-2-methyl-(2-(mopholin-4-yl)ethyl)-1H-indole","1-(2,3-dichlorobenzoyl)-5-methoxy-2-methyl-(2-(mopholin-4-yl)ethyl)-1H-indole","C463040","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23463621","Comparative proteomic and phosphoproteomic profiling of pancreatic adenocarcinoma cells treated with CB1 or CB2 agonists.","23463621",136]
["1-(2,4-diamino phenylazo)naphthalene","1-(2,4-diamino phenylazo)naphthalene","C568744","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2011,"21286794","Azonium-ammonium tautomerism and inclusion complexation of 1-(2,4-diamino phenylazo) naphthalene and 4-aminoazobenzene.","21286794",136]
["1-(2,4-dichlorobenzyl)indazole-3-carbohydrazide","1-(2,4-dichlorobenzyl)indazole-3-carbohydrazide","C432482","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20713173","Adjudin-mediated Sertoli-germ cell junction disassembly affects Sertoli cell barrier function in vitro and in vivo.","20713173",136]
["1-(2,4-dimethoxyphenyl)-3-(1-methylindolyl)propenone","1-(2,4-dimethoxyphenyl)-3-(1-methylindolyl)propenone","C546292","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2009,"19440149","Investigation of a new 1,3-diarylpropenone as a potential antimitotic agent targeting bladder carcinoma.","19440149",136]
["1-(2,4-dimethoxyphenyl)-3-(1-methylindolyl)propenone","1-(2,4-dimethoxyphenyl)-3-(1-methylindolyl)propenone","C546292","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"19440149","Investigation of a new 1,3-diarylpropenone as a potential antimitotic agent targeting bladder carcinoma.","19440149",136]
["1-(2',4'-dinitroaminophenyl)-4,4,6-trimethyl-1,4-dihydropyrimidine-2-thiol","1-(2',4'-dinitroaminophenyl)-4,4,6-trimethyl-1,4-dihydropyrimidine-2-thiol","C553037","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2010,"20298898","Synergistic liquid-liquid extractive spectrophotometric determination of gold(III) using 1-(2',4'-dinitro aminophenyl)-4,4,6-trimethyl-1,4-dihydropyrimidine-2-thiol.","20298898",136]
["1-(2',4'-dinitroaminophenyl)-4,4,6-trimethyl-1,4-dihydropyrimidine-2-thiol","1-(2',4'-dinitroaminophenyl)-4,4,6-trimethyl-1,4-dihydropyrimidine-2-thiol","C553037","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2011,"21330190","Synergistic extraction and spectrophotometric determination of copper(II) using 1-(2',4'-dinitro aminophenyl)-4,4,6-trimethyl-1,4-dihydropyrimidine-2-thiol: analysis of alloys, pharmaceuticals and biological samples.","21330190",136]
["1-(2,6-dichlorophenyl)indolin-2-one","1-(2,6-dichlorophenyl)indolin-2-one","C456899","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2002,"11929665","Densitometric determination of diclofenac, 1-(2,6-dichlorophenyl)indolin-2-one and indolin-2-one in pharmaceutical preparations and model solutions.","11929665",136]
["1-(2',6'-difluorophenyl)-1H,3H-thiazolo(3,4-a)benzimidazole","1-(2',6'-difluorophenyl)-1H,3H-thiazolo(3,4-a)benzimidazole","C073244","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2001,"11165139","Apoptotic effects of thiazolobenzimidazole derivatives on sensitive and multidrug resistant leukaemic cells.","11165139",136]
["1-(2',6'-difluorophenyl)-1H,3H-thiazolo(3,4-a)benzimidazole","1-(2',6'-difluorophenyl)-1H,3H-thiazolo(3,4-a)benzimidazole","C073244","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,1998,"9893665","Selective induction of apoptosis in multidrug resistant HL60R cells by the thiazolobenzoimidazole derivative 1-(2,6-difluorophenyl)-1H,3H-thiazolo [3,4-a] benzimidazole (TBZ).","9893665",136]
["1-(2',6'-difluorophenyl)-1H,3H-thiazolo(3,4-a)benzimidazole","1-(2',6'-difluorophenyl)-1H,3H-thiazolo(3,4-a)benzimidazole","C073244","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1993,"8415398","Solubilization of thiazolobenzimidazole using a combination of pH adjustment and complexation with 2-hydroxypropyl-beta-cyclodextrin.","8415398",136]
["1-(2,6-dihydroxy-4-methoxyphenyl)-2-(4-hydroxyphenyl)ethanone","1-(2,6-dihydroxy-4-methoxyphenyl)-2-(4-hydroxyphenyl)ethanone","C000593722","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2014,"24451128","1-(2,6-dihydroxy-4-methoxyphenyl)-2-(4-hydroxyphenyl) ethanone-induced cell cycle arrest in G₁/G₀ in HT-29 cells human colon adenocarcinoma cells.","24451128",136]
["1-(2,6-dimethylphenoxy)-2-(3,4-dimethoxyphenylethylamino)propane","1-(2,6-dimethylphenoxy)-2-(3,4-dimethoxyphenylethylamino)propane","C057485","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2006,"16413710","Floating matrix dosage form for phenoporlamine hydrochloride based on gas forming agent: in vitro and in vivo evaluation in healthy volunteers.","16413710",136]
["1-(2,7-difluoro-6-hydroxy-4,5-bis(1,2,3-dithioarsolan-2-yl)-3-oxo-3H-xanthen-9-yl)-4-oxo-4H-quinolizine-3-carboxylic Acid","1-(2,7-difluoro-6-hydroxy-4,5-bis(1,2,3-dithioarsolan-2-yl)-3-oxo-3H-xanthen-9-yl)-4-oxo-4H-quinolizine-3-carboxylic Acid","C000592216","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"24447167","Design and synthesis of a FlAsH-type Mg2+ fluorescent probe for specific protein labeling.","24447167",136]
["1-(2-aminoethyl-(6-hydrazinopyridine-3-carbamidyl))-3,5-bis-(2-fluorobenzylidene)-4-piperidone","1-(2-aminoethyl-(6-hydrazinopyridine-3-carbamidyl))-3,5-bis-(2-fluorobenzylidene)-4-piperidone","C571719","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22107757","Anticancer activity of an imageable curcuminoid 1-[2-aminoethyl-(6-hydrazinopyridine-3-carbamidyl)-3,5-bis-(2-fluorobenzylidene)-4-piperidone (EFAH).","22107757",136]
["1-(2-bromo-3,4,5-trimethoxyphenyl)-3-(3-hydroxy-4-methoxyphenylamino)prop-2-en-1-one","1-(2-bromo-3,4,5-trimethoxyphenyl)-3-(3-hydroxy-4-methoxyphenylamino)prop-2-en-1-one","C575279","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22587519","(Z)-1-aryl-3-arylamino-2-propen-1-ones, highly active stimulators of tubulin polymerization: synthesis, structure-activity relationship (SAR), tubulin polymerization, and cell growth inhibition studies.","22587519",136]
["1-(2-bromo-3,4,5-trimethoxyphenyl)-3-(3-hydroxy-4-methoxyphenylamino)prop-2-en-1-one","1-(2-bromo-3,4,5-trimethoxyphenyl)-3-(3-hydroxy-4-methoxyphenylamino)prop-2-en-1-one","C575279","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22587519","(Z)-1-aryl-3-arylamino-2-propen-1-ones, highly active stimulators of tubulin polymerization: synthesis, structure-activity relationship (SAR), tubulin polymerization, and cell growth inhibition studies.","22587519",136]
["1-(2-bromobenzyloxy)-4-bromo-2-benzylidene rhodanine","1-(2-bromobenzyloxy)-4-bromo-2-benzylidene rhodanine","C550529","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2010,"19960436","Phosphatase of regenerating liver-3 as a convergent therapeutic target for lymph node metastasis in esophageal squamous cell carcinoma.","19960436",136]
["1-(2-bromobenzyloxy)-4-bromo-2-benzylidene rhodanine","1-(2-bromobenzyloxy)-4-bromo-2-benzylidene rhodanine","C550529","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2010,"19960436","Phosphatase of regenerating liver-3 as a convergent therapeutic target for lymph node metastasis in esophageal squamous cell carcinoma.","19960436",136]
["1-(2-bromoethyl)-6-oxyl-5,5,7,7-tetramethyltetrahydroimidazo(1,5-b)(1,2,4)oxadiazol-2-one","1-(2-bromoethyl)-6-oxyl-5,5,7,7-tetramethyltetrahydroimidazo(1,5-b)(1,2,4)oxadiazol-2-one","C527426","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2008,"18085792","Studies toward the synthesis of 4-(2-R-ethyl)amino-2,2,5,5-tetramethyl-3-imidazoline 1-oxyls. nucleophilic substitution of bromide in the N-Alkyl chain of the 1,2,4-oxadiazol-2-one precursor.","18085792",136]
["1-(2'-carboxyethyl)-3-hydroxy-2-methyl-4-pyridinone","1-(2'-carboxyethyl)-3-hydroxy-2-methyl-4-pyridinone","C415337","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2000,"10857911","Synthesis, chelating properties towards gallium and biological evaluation of two N-substituted 3-hydroxy-4-pyridinones.","10857911",136]
["1-(2-carboxyethyl)adenine","1-(2-carboxyethyl)adenine","C026369","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1979,"45009","In vitro Dimroth rearrangement of 1-(2-carboxyethyl) adenine to N6-(2-carboxyethyl)adenine in single-stranded calf thymus DNA.","45009",136]
["1-(2-chloro-2-phenylethyl)-3-(4-methylphenyl)-1H-pyrazolo(3,4-d)pyrimidin-4-amine","1-(2-chloro-2-phenylethyl)-3-(4-methylphenyl)-1H-pyrazolo(3,4-d)pyrimidin-4-amine","C000601372","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25923950","Studies on the ATP Binding Site of Fyn Kinase for the Identification of New Inhibitors and Their Evaluation as Potential Agents against Tauopathies and Tumors.","25923950",136]
["1-(2-chloro-2-phenylethyl)-6-(methylthio)-N-(2-phenylethyl)-1H-pyrazolo(3,4-d)pyrimidin-4-amine","1-(2-chloro-2-phenylethyl)-6-(methylthio)-N-(2-phenylethyl)-1H-pyrazolo(3,4-d)pyrimidin-4-amine","C531241","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2008,"18509002","Cytotoxic effects of a novel pyrazolopyrimidine derivative entrapped in liposomes in anaplastic thyroid cancer cells in vitro and in xenograft tumors in vivo.","18509002",136]
["1-(2-chloro-6-fluorophenyl)-5-methylindolin-2-one","1-(2-chloro-6-fluorophenyl)-5-methylindolin-2-one","C555769","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2010,"21060305","Synthesis, characterization and pharmacological evaluation of 1-(2-chloro-6-fluorophenyl)-5-methylindolin-2-one: a new anti-inflammatory compound with reduced gastric ulceration properties.","21060305",136]
["1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one","1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one","C569107","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2011,"21903591","Antagonists of anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction are novel regulators of cell growth and apoptosis.","21903591",136]
["1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one","1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one","C569107","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2014,"24598827","CARP-1 functional mimetics are a novel class of small molecule inhibitors of malignant pleural mesothelioma cells.","24598827",136]
["1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one","1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one","C569107","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2011,"21903591","Antagonists of anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction are novel regulators of cell growth and apoptosis.","21903591",136]
["1-(2-chloroethyl)-1-nitrosourea","1-(2-chloroethyl)-1-nitrosourea","C017139","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2002,"12394182","Inhibition of O6-alkylguanine-DNA alkyltransferase by O6-benzyl-N2-acetylguanosine increases chloroethylnitrosourea-induced apoptosis in Mer+ human melanoma cells.","12394182",136]
["1-(2-chloroethyl)-1-nitrosourea","1-(2-chloroethyl)-1-nitrosourea","C017139","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2006,"16557598","Bystander effects are induced by CENU treatment and associated with altered protein secretory activity of treated tumor cells: a relay for chemotherapy?","16557598",136]
["1-(2-chloroethyl)-1-nitrosourea","1-(2-chloroethyl)-1-nitrosourea","C017139","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1987,"3689390","Synthesis and characterization of O6-(2-chloroethyl)guanine: a putative intermediate in the cytotoxic reaction of chloroethylnitrosoureas with DNA.","3689390",136]
["1-(2-chloroethyl)-3-(2-(5-fluoro-3-oxobenzoselenazol-2(3H)-yl)ethyl)-1-nitrosourea","1-(2-chloroethyl)-3-(2-(5-fluoro-3-oxobenzoselenazol-2(3H)-yl)ethyl)-1-nitrosourea","C000613750","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27453265","Synthesis, SAR and biological evaluation of a novel series of 1-(2-chloroethyl)-1-nitroso-3-(2-(3-oxobenzoelenazol-2(3H)-yl)ethyl) urea: Organoselenium compounds for cancer therapy.","27453265",136]
["1-(2-chloroethyl)-3-(2-(dimethylaminosulfonyl)ethyl)-1-nitrosourea","1-(2-chloroethyl)-3-(2-(dimethylaminosulfonyl)ethyl)-1-nitrosourea","C052991","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1988,"3372655","Determination of tauromustine, a nitrosourea-based antitumour agent, in plasma by high-performance liquid chromatography.","3372655",136]
["1-(2-chloroethyl)-3-(2-(dimethylaminosulfonyl)ethyl)-1-nitrosourea","1-(2-chloroethyl)-3-(2-(dimethylaminosulfonyl)ethyl)-1-nitrosourea","C052991","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1993,"8257744","Fluorimetric determination of tauromustine (a novel antitumour agent) in formulations and biological fluids.","8257744",136]
["1-(2-chloroethyl)-3-(2-(dimethylaminosulfonyl)ethyl)-1-nitrosourea","1-(2-chloroethyl)-3-(2-(dimethylaminosulfonyl)ethyl)-1-nitrosourea","C052991","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1993,"8508500","Measurement and characterization of the denitrosation of tauromustine and related nitrosoureas by glutathione transferases in liver cytosol from various species.","8508500",136]
["1-(2-chloroimidazo(1,2-a)pyridin-3-ylsulfonyl)-3-(4,6-dimethoxypyrimidin-2-yl)urea","1-(2-chloroimidazo(1,2-a)pyridin-3-ylsulfonyl)-3-(4,6-dimethoxypyrimidin-2-yl)urea","C433346","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2001,"11513672","Kinetics and mechanism of imazosulfuron hydrolysis.","11513672",136]
["1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","C472829","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2004,"14749474","Induction of redox imbalance and apoptosis in multiple myeloma cells by the novel triterpenoid 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid.","14749474",136]
["1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","C472829","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2004,"15070698","The bortezomib/proteasome inhibitor PS-341 and triterpenoid CDDO-Im induce synergistic anti-multiple myeloma (MM) activity and overcome bortezomib resistance.","15070698",136]
["1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","C472829","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2004,"15486192","Peroxisome proliferator-activated receptor gamma and retinoid X receptor ligands are potent inducers of differentiation and apoptosis in leukemias.","15486192",136]
["1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","C472829","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2005,"15746941","Triterpenoid CDDO-Im downregulates PML/RARalpha expression in acute promyelocytic leukemia cells.","15746941",136]
["1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","C472829","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2005,"15930300","Synthetic triterpenoids cooperate with tumor necrosis factor-related apoptosis-inducing ligand to induce apoptosis of breast cancer cells.","15930300",136]
["1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","C472829","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2005,"16118208","2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) directly targets mitochondrial glutathione to induce apoptosis in pancreatic cancer.","16118208",136]
["1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","C472829","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2006,"16551868","A synthetic triterpenoid, CDDO-Me, inhibits IkappaBalpha kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor kappaB-regulated gene products in human leukemic cells.","16551868",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C899,B899)","v":"1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole"},"1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","C472829","5_KE",768,5,"Cytotoxicity","Increase",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J899,K899)","v":"Apoptosis"},"D017209","Apoptosis",1,1,2006,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q899,Q899)","v":"16857804"},"The synthetic triterpenoid CDDO-Imidazolide suppresses STAT phosphorylation and induces apoptosis in myeloma and lung cancer cells.","16857804",136]
["1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","C472829","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2007,"17361329","Synthetic triterpenoids inhibit growth and induce apoptosis in human glioblastoma and neuroblastoma cells through inhibition of prosurvival Akt, NF-kappaB and Notch1 signaling.","17361329",136]
["1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","C472829","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2008,"18033322","Synthetic triterpenoids have cytotoxicity in pediatric acute lymphoblastic leukemia cell lines but cytotoxicity is independent of induced ceramide increase in MOLT-4 cells.","18033322",136]
["1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","C472829","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2008,"18259941","The synthetic triterpenoid CDDO-Im inhibits fatty acid synthase expression and has antiproliferative and proapoptotic effects in human liposarcoma cells.","18259941",136]
["1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","C472829","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2008,"18304628","Resistance of acute myeloid leukemic cells to the triterpenoid CDDO-Imidazolide is associated with low caspase-8 and FADD levels.","18304628",136]
["1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","C472829","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2008,"18468679","CDDO-imidazolide mediated inhibition of malignant cell growth in Waldenström macroglobulinemia.","18468679",136]
["1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","C472829","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2009,"19364626","High sensitivity of ovarian cancer cells to the synthetic triterpenoid CDDO-Imidazolide.","19364626",136]
["1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","C472829","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"20392997","Synthetic triterpenoids inhibit growth, induce apoptosis and suppress pro-survival Akt, mTOR and NF-{kappa}B signaling proteins in colorectal cancer cells.","20392997",136]
["1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","C472829","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"21035854","CDDO-Im is a stimulator of megakaryocytic differentiation.","21035854",136]
["1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","C472829","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"21074266","CDDO-Im, an antitumor molecule that also improves platetet production.","21074266",136]
["1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","C472829","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"25229616","A synthetic triterpenoid CDDO-Im inhibits tumorsphere formation by regulating stem cell signaling pathways in triple-negative breast cancer.","25229616",136]
["1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","C472829","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25504014","Protection of HepG2 cells against acrolein toxicity by 2-cyano-3,12-dioxooleana-1,9-dien-28-imidazolide via glutathione-mediated mechanism.","25504014",136]
["1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","C472829","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2005,"16118208","2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) directly targets mitochondrial glutathione to induce apoptosis in pancreatic cancer.","16118208",136]
["1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","C472829","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2004,"15486192","Peroxisome proliferator-activated receptor gamma and retinoid X receptor ligands are potent inducers of differentiation and apoptosis in leukemias.","15486192",136]
["1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","C472829","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2006,"16857804","The synthetic triterpenoid CDDO-Imidazolide suppresses STAT phosphorylation and induces apoptosis in myeloma and lung cancer cells.","16857804",136]
["1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","C472829","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2007,"17361329","Synthetic triterpenoids inhibit growth and induce apoptosis in human glioblastoma and neuroblastoma cells through inhibition of prosurvival Akt, NF-kappaB and Notch1 signaling.","17361329",136]
["1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","C472829","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2008,"18259941","The synthetic triterpenoid CDDO-Im inhibits fatty acid synthase expression and has antiproliferative and proapoptotic effects in human liposarcoma cells.","18259941",136]
["1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","C472829","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2008,"18608528","Immunomodulatory activity of synthetic triterpenoids: inhibition of lymphocyte proliferation, cell-mediated cytotoxicity, and cytokine gene expression through suppression of NF-kappaB.","18608528",136]
["1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","C472829","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"19364626","High sensitivity of ovarian cancer cells to the synthetic triterpenoid CDDO-Imidazolide.","19364626",136]
["1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","C472829","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21035854","CDDO-Im is a stimulator of megakaryocytic differentiation.","21035854",136]
["1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","C472829","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21074266","CDDO-Im, an antitumor molecule that also improves platetet production.","21074266",136]
["1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole","C472829","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2009,"19371629","CDDO-Im protects from acetaminophen hepatotoxicity through induction of Nrf2-dependent genes.","19371629",136]
["1-(2-fluoro-2-deoxy-3,5-O-dibenzoylarabinofuranosyl)-5-bromouracil","1-(2-fluoro-2-deoxy-3,5-O-dibenzoylarabinofuranosyl)-5-bromouracil","C470853","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2008,"18589308","[18F]FBAU 3',5'-dibenzoate, a lipophilic prodrug, enhances brain uptake of the cell proliferation tracer [18F]FBAU.","18589308",136]
["1-(2-fluoro-2-deoxyarabinofuranosyl)-5-bromouracil","1-(2-fluoro-2-deoxyarabinofuranosyl)-5-bromouracil","C470854","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2008,"18589308","[18F]FBAU 3',5'-dibenzoate, a lipophilic prodrug, enhances brain uptake of the cell proliferation tracer [18F]FBAU.","18589308",136]
["1-(2-fluoro-4-(1H-pyrazol-1-yl)phenyl)-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one","1-(2-fluoro-4-(1H-pyrazol-1-yl)phenyl)-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one","C000594749","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Atrophy","D001284","Atrophy",1,1,2017,"27811172","TAK-063, a Novel Phosphodiesterase 10A Inhibitor, Protects from Striatal Neurodegeneration and Ameliorates Behavioral Deficits in the R6/2 Mouse Model of Huntington's Disease.","27811172",136]
["1-(2-guanidinoethyl)-4-(2-hydroxyethyl)-1,4,7-triazacyclononane hydrochloride","1-(2-guanidinoethyl)-4-(2-hydroxyethyl)-1,4,7-triazacyclononane hydrochloride","C518837","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"17269829","Synthesis and DNA cleavage activity of artificial receptor 1,4,7-triazacyclononane containing guanidinoethyl and hydroxyethyl side arms.","17269829",136]
["1-(2-hydroxy-2-methylpropyl)-N-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide","1-(2-hydroxy-2-methylpropyl)-N-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide","C530596","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22836051","Higher levels of c-Met expression and phosphorylation identify cell lines with increased sensitivity to AMG-458, a novel selective c-Met inhibitor with radiosensitizing effects.","22836051",136]
["1-(2-hydroxy-2-methylpropyl)-N-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide","1-(2-hydroxy-2-methylpropyl)-N-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide","C530596","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28751462","Selective MET Kinase Inhibition in MET-Dependent Glioma Models Alters Gene Expression and Induces Tumor Plasticity.","28751462",136]
["1-(2-hydroxy-3- methyl 4,5-dimethoxyphenyl)-3-(1H-pyrrol-2-yl)-2-propen-1-one","1-(2-hydroxy-3- methyl 4,5-dimethoxyphenyl)-3-(1H-pyrrol-2-yl)-2-propen-1-one","C000608030","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"26068427","Glycopentalone, a novel compound from Glycosmis pentaphylla (Retz.) Correa with potent anti-hepatocellular carcinoma activity.","26068427",136]
["1-(2-hydroxy-3-methoxybenzaldehyde)-4-aminosalicylhydrazone","1-(2-hydroxy-3-methoxybenzaldehyde)-4-aminosalicylhydrazone","C572874","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25850340","Anti-proliferative effect of Fe(III) complexed with 1-(2-hydroxy-3-methoxybenzaldehyde)-4-aminosalicylhydrazone in HepG2 cells.","25850340",136]
["1-(2-hydroxy-3-methoxybenzaldehyde)-4-aminosalicylhydrazone","1-(2-hydroxy-3-methoxybenzaldehyde)-4-aminosalicylhydrazone","C572874","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25850340","Anti-proliferative effect of Fe(III) complexed with 1-(2-hydroxy-3-methoxybenzaldehyde)-4-aminosalicylhydrazone in HepG2 cells.","25850340",136]
["1-(2-hydroxy-3-methoxybenzaldehyde)-4-aminosalicylhydrazone","1-(2-hydroxy-3-methoxybenzaldehyde)-4-aminosalicylhydrazone","C572874","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"22316617","Development of a fluorescent chelating ligand for scandium ion having a Schiff base moiety.","22316617",136]
["1-(2-hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione","1-(2-hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione","C506624","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2005,"16277400","Induction of apoptosis by 1-(2-hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione through reactive oxygen species production, GADD153 expression, and caspases activation in human epidermoid carcinoma cells.","16277400",136]
["1-(2-hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione","1-(2-hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione","C506624","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"20971808","CEBPD reverses RB/E2F1-mediated gene repression and participates in HMDB-induced apoptosis of cancer cells.","20971808",136]
["1-(2-hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione","1-(2-hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione","C506624","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"26358750","HMDB and 5-AzadC Combination Reverses Tumor Suppressor CCAAT/Enhancer-Binding Protein Delta to Strengthen the Death of Liver Cancer Cells.","26358750",136]
["1-(2-hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione","1-(2-hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione","C506624","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27527160","1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione Induces G1 Cell Cycle Arrest and Autophagy in HeLa Cervical Cancer Cells.","27527160",136]
["1-(2-hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione","1-(2-hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione","C506624","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27527160","1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione Induces G1 Cell Cycle Arrest and Autophagy in HeLa Cervical Cancer Cells.","27527160",136]
["1-(2''-hydroxycyclohexyl)-3'-aminopropyl-4-(3'-aminopropyl)piperazine","1-(2''-hydroxycyclohexyl)-3'-aminopropyl-4-(3'-aminopropyl)piperazine","C531920","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2008,"18280775","Model-based analysis for kinetic complexation study of Pizda and Cu(II).","18280775",136]
["1-(2-hydroxyethyl)-3-(6-(2-methoxyphenyl)benzo(d)thiazol-2-yl)urea","1-(2-hydroxyethyl)-3-(6-(2-methoxyphenyl)benzo(d)thiazol-2-yl)urea","C000589392","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24657654","HS-438, a new inhibitor of imatinib-resistant BCR-ABL T315I mutation in chronic myeloid leukemia.","24657654",136]
["1-(2-hydroxyethyl)-3-(6-(2-methoxyphenyl)benzo(d)thiazol-2-yl)urea","1-(2-hydroxyethyl)-3-(6-(2-methoxyphenyl)benzo(d)thiazol-2-yl)urea","C000589392","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24657654","HS-438, a new inhibitor of imatinib-resistant BCR-ABL T315I mutation in chronic myeloid leukemia.","24657654",136]
["1-(2-hydroxyethyl)-3,5,7-triaza-1-azoniatricyclo(3.3.1.1(3,7))decane bromide","1-(2-hydroxyethyl)-3,5,7-triaza-1-azoniatricyclo(3.3.1.1(3,7))decane bromide","C574188","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22402131","A small molecule focal adhesion kinase (FAK) inhibitor, targeting Y397 site: 1-(2-hydroxyethyl)-3, 5, 7-triaza-1-azoniatricyclo [3.3.1.1(3,7)]decane; bromide effectively inhibits FAK autophosphorylation activity and decreases cancer cell viability, clonogenicity and tumor growth in vivo.","22402131",136]
["1-(2-methoxy-5-nitrophenylazo)-2-hydroxy-3-(3-nitrophenylcarbamoyl)naphthalene","1-(2-methoxy-5-nitrophenylazo)-2-hydroxy-3-(3-nitrophenylcarbamoyl)naphthalene","C506598","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2008,"18006230","Photocatalytic degradation of Direct Red 23 dye using UV/TiO2: Effect of operational parameters.","18006230",136]
["1-(2-methoxy-5-nitrophenylazo)-2-hydroxy-3-(3-nitrophenylcarbamoyl)naphthalene","1-(2-methoxy-5-nitrophenylazo)-2-hydroxy-3-(3-nitrophenylcarbamoyl)naphthalene","C506598","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2013,"23423868","Comparison of photocatalytic degradation of dyes in relation to their structure.","23423868",136]
["1-(2-methoxy-5-nitrophenylazo)-2-hydroxy-3-(3-nitrophenylcarbamoyl)naphthalene","1-(2-methoxy-5-nitrophenylazo)-2-hydroxy-3-(3-nitrophenylcarbamoyl)naphthalene","C506598","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2015,"25087169","Removal of Direct Red 23 from aqueous solution using corn stalks: isotherms, kinetics and thermodynamic studies.","25087169",136]
["1-(2-methoxybenzylidene)-4-phenylthiosemicarbazide","1-(2-methoxybenzylidene)-4-phenylthiosemicarbazide","C538805","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2008,"18448384","1-(2-methoxybenzylidene)-4-phenylthiosemicarbazide as OFF-ON fluorescent chemodosimeter for detection of Cu2+ in acetonitrile-water binary solvents.","18448384",136]
["1-(2-methoxyphenyl)piperazine","1-(2-methoxyphenyl)piperazine","C040083","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,2,2016,"27450225","In vitro mutagenic, antimutagenic, and antioxidant activities evaluation and biotransformation of some bioactive 4-substituted 1-(2-methoxyphenyl)piperazine derivatives.","27450225",136]
["1-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea","1-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea","C420062","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"23031594","Hydrolytic instability of the important orexin 1 receptor antagonist SB-334867: possible confounding effects on in vivo and in vitro studies.","23031594",136]
["1-(2-methylphenyl)-4-methylamino-6-methyl-2,3-dihydropyrrolo(3,2-c)quinoline","1-(2-methylphenyl)-4-methylamino-6-methyl-2,3-dihydropyrrolo(3,2-c)quinoline","C069657","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24641279","The TRPC channel blocker SKF 96365 inhibits glioblastoma cell growth by enhancing reverse mode of the Na(+) /Ca(2+) exchanger and increasing intracellular Ca(2+).","24641279",136]
["1-(2-naphthyl)-3-methyl-5-pyrazolone","1-(2-naphthyl)-3-methyl-5-pyrazolone","C527199","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2008,"18581853","[Preparation of 1-(2-naphthyl) -3-methyl-5-pyrazolone as pre-column derivatization reagent for the determination of saccharides using high performance liquid chromatography-mass spectrometry].","18581853",136]
["1-(2-nitro-1-imidazolyl)-3-aziridino-2-propanol","1-(2-nitro-1-imidazolyl)-3-aziridino-2-propanol","C041712","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1992,"1532139","Inactivation and repair of double-stranded DNA damaged by the aziridinyl nitroimidazole RSU 1069.","1532139",136]
["1-(2-nitro-1-imidazolyl)-3-aziridino-2-propanol","1-(2-nitro-1-imidazolyl)-3-aziridino-2-propanol","C041712","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1991,"1828345","Interaction of RSU 1069 and 1137 with DNA in vitro. Biological implications and mechanistic aspects.","1828345",136]
["1-(2-nitro-1-imidazolyl)-3-aziridino-2-propanol","1-(2-nitro-1-imidazolyl)-3-aziridino-2-propanol","C041712","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1991,"1884367","Effect of oxygenation, pH and hyperthermia on RSU-1069 in vitro and in vivo with radiation in the FSaIIC murine fibrosarcoma.","1884367",136]
["1-(2-nitro-1-imidazolyl)-3-aziridino-2-propanol","1-(2-nitro-1-imidazolyl)-3-aziridino-2-propanol","C041712","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1990,"2383289","A comparison of the techniques of alkaline filter elution and alkaline sucrose sedimentation used to assess DNA damage induced by 2-nitroimidazoles.","2383289",136]
["1-(2-nitro-1-imidazolyl)-3-aziridino-2-propanol","1-(2-nitro-1-imidazolyl)-3-aziridino-2-propanol","C041712","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1986,"3754447","Interaction of the aziridine moiety of RSU-1069 with nucleotides and inorganic phosphate. Implications for alkylation of DNA.","3754447",136]
["1-(2-nitro-1-imidazolyl)-3-aziridino-2-propanol","1-(2-nitro-1-imidazolyl)-3-aziridino-2-propanol","C041712","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1985,"3902026","Induction of DNA strand breaks by RSU-1069, a nitroimidazole-aziridine radiosensitizer. Role of binding of both unreduced and radiation-reduced forms to DNA, in vitro.","3902026",136]
["1-(2-nitro-1-imidazolyl)-3-aziridino-2-propanol","1-(2-nitro-1-imidazolyl)-3-aziridino-2-propanol","C041712","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1995,"7779413","Use of the comet assay to detect hypoxic cells in murine tumours and normal tissues exposed to bioreductive drugs.","7779413",136]
["1-(2-nitro-1-imidazolyl)-3-aziridino-2-propanol","1-(2-nitro-1-imidazolyl)-3-aziridino-2-propanol","C041712","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,1996,"9023383","A comparison of the physiological effects of RSU1069 and RB6145 in the SCCVII murine tumour.","9023383",136]
["1-(2-nitrophenyl)ethyl sulfate","1-(2-nitrophenyl)ethyl sulfate","C473956","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2002,"12414718","Characterization of a new caged proton capable of inducing large pH jumps.","12414718",136]
["1-(2-nitrophenyl)-ethylhexadecylsulfonate","1-(2-nitrophenyl)-ethylhexadecylsulfonate","C000614029","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2016,"27017356","Modulating intracellular acidification by regulating the incubation time of proton caged compounds.","27017356",136]
["1-(2-nitrophenyl)ethylpyranine","1-(2-nitrophenyl)ethylpyranine","C466316","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2002,"11908850","The efficiency of two-photon photolysis of a \"caged\" fluorophore, o-1-(2-nitrophenyl)ethylpyranine, in relation to photodamage of synaptic terminals.","11908850",136]
["1-(2-pyridylazo)-2-naphthol","1-(2-pyridylazo)-2-naphthol","C041728","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2003,"14640450","Second and first-derivative spectrophotometry for efficient simultaneous and individual determination of palladium and cobalt using 1-(2-pyridylazo)-2-naphthol in sodium dodecylsulfate micellar media.","14640450",136]
["1-(2-pyridylazo)-2-naphthol","1-(2-pyridylazo)-2-naphthol","C041728","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2004,"14670476","H-point standard addition method for simultaneous spectrophotometric determination of Co(II) and Ni(II) by 1-(2-pyridylazo)2-naphthol in micellar media.","14670476",136]
["1-(2-pyridylazo)-2-naphthol","1-(2-pyridylazo)-2-naphthol","C041728","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2004,"15279103","Differential pulse polarographic determination of lead in standard alloys and biological samples after separation and preconcentration with PAN.","15279103",136]
["1-(2-pyridylazo)-2-naphthol","1-(2-pyridylazo)-2-naphthol","C041728","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2004,"15293410","H-point standard addition method for the selective simultaneous determination of nickel and copper using 1-(2-pyridylazo)-2-naphthol in Tween 80 micellar media.","15293410",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C963,B963)","v":"1-(2-pyridylazo)-2-naphthol"},"1-(2-pyridylazo)-2-naphthol","C041728","1_MIE",867,1,"Intracellular pH","Decrease",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J963,K963)","v":"Hydrogen-Ion Concentration"},"D006863","Hydrogen-Ion Concentration",2,2,2010,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q963,Q963)","v":"20458405"},"Multiwalled carbon nanotube modified with 1-(2-pyridylazo)-2-naphthol for stripping voltammetric determination of Pb(II).","20458405",136]
["1-(2-pyridylazo)-2-naphthol","1-(2-pyridylazo)-2-naphthol","C041728","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2010,"20922965","Solid-phase extraction of antimony using chemically modified SiO2-PAN nanoparticles.","20922965",136]
["1-(2-pyridylazo)-2-naphthol","1-(2-pyridylazo)-2-naphthol","C041728","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"22306448","Highly selective and sensitive colorimetric probe for hydrogen sulfide by a copper (II) complex of azo-dye based on chemosensing ensemble approach.","22306448",136]
["1-(2-pyridylazo)-2-naphthol","1-(2-pyridylazo)-2-naphthol","C041728","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"24672879","Enrichment of copper as 1-(2-pyridylazo)-2-naphthol complex by the combination of dispersive liquid-liquid microextraction/flame atomic absorption spectrometry.","24672879",136]
["1-(2-pyridylazo)-2-naphthol","1-(2-pyridylazo)-2-naphthol","C041728","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2016,"26940893","Reflection of the Physiochemical Characteristics of 1-(2-pyridylazo)-2-naphthol on the Pre-concentration of Trace Heavy Metals.","26940893",136]
["1-(2-pyridylmethylidene)-5-(salicylidene)thiocarbonylhydrazone","1-(2-pyridylmethylidene)-5-(salicylidene)thiocarbonylhydrazone","C049366","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1986,"3717591","Spectrophotometric determination of palladium in catalysts and carbenicillin with 1-(2-pyridylmethylidene)-5-(salicylidene)-thiocarbohydr azone.","3717591",136]
["1-(2-pyrrolidinylcarbonyl)-2-pyrrolidinylboronic acid","1-(2-pyrrolidinylcarbonyl)-2-pyrrolidinylboronic acid","C083014","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1994,"7918465","Solution structures of active and inactive forms of the DP IV (CD26) inhibitor Pro-boroPro determined by NMR spectroscopy.","7918465",136]
["1-(2-thiazolylazo)-2-naphthol","1-(2-thiazolylazo)-2-naphthol","C054556","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2004,"15363516","Removal and recovery of mercury(II) from hazardous wastes using 1-(2-thiazolylazo)-2-naphthol functionalized activated carbon as solid phase extractant.","15363516",136]
["1-(2-thiazolylazo)-p-cresol","1-(2-thiazolylazo)-p-cresol","C496275","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"24291515","Spectrophotometric determination of acidity constants of 2-(2-Thiazolylazo)-Cresol in various water-organic solvent media mixtures using chemometrics methods.","24291515",136]
["1-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea","1-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea","C582286","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27248664","BO-1055, a novel DNA cross-linking agent with remarkable low myelotoxicity shows potent activity in sarcoma models.","27248664",136]
["1-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea","1-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea","C582286","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27248664","BO-1055, a novel DNA cross-linking agent with remarkable low myelotoxicity shows potent activity in sarcoma models.","27248664",136]
["1-(3-((4-(4-acetylphenyl)piperazin-1-yl)methyl)-4-hydroxy-5-methoxyphenyl)-3-(pyridin-3-yl)prop-2-en-1-one","1-(3-((4-(4-acetylphenyl)piperazin-1-yl)methyl)-4-hydroxy-5-methoxyphenyl)-3-(pyridin-3-yl)prop-2-en-1-one","C559076","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2011,"21377368","New bichalcone analogs as NF-κB inhibitors and as cytotoxic agents inducing Fas/CD95-dependent apoptosis.","21377368",136]
["1-(3-((4-(4-acetylphenyl)piperazin-1-yl)methyl)-4-hydroxy-5-methoxyphenyl)-3-(pyridin-3-yl)prop-2-en-1-one","1-(3-((4-(4-acetylphenyl)piperazin-1-yl)methyl)-4-hydroxy-5-methoxyphenyl)-3-(pyridin-3-yl)prop-2-en-1-one","C559076","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2015,"26408703","Synthetic Bichalcone TSWU-BR23 Induces Apoptosis of Human Colon Cancer HT-29 Cells by p53-Mediated Mitochondrial Oligomerization of BAX/BAK and Lipid Raft Localization of CD95/FADD.","26408703",136]
["1-(3-(1H-imidazol-1-yl)propyl)-4-benzoyl-5-(4-bromophenyl)-3-isopropoxy-1H-pyrrol-2(5H)-one","1-(3-(1H-imidazol-1-yl)propyl)-4-benzoyl-5-(4-bromophenyl)-3-isopropoxy-1H-pyrrol-2(5H)-one","C577939","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"23046248","Discovery, synthesis, and biological evaluation of orally active pyrrolidone derivatives as novel inhibitors of p53-MDM2 protein-protein interaction.","23046248",136]
["1-(3-(1H-imidazol-1-yl)propyl)-4-benzoyl-5-(4-bromophenyl)-3-isopropoxy-1H-pyrrol-2(5H)-one","1-(3-(1H-imidazol-1-yl)propyl)-4-benzoyl-5-(4-bromophenyl)-3-isopropoxy-1H-pyrrol-2(5H)-one","C577939","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"23046248","Discovery, synthesis, and biological evaluation of orally active pyrrolidone derivatives as novel inhibitors of p53-MDM2 protein-protein interaction.","23046248",136]
["1-(3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo(4,5)cyclohepta(1,2-b)pyridin-7-yl)-N-(pyridin-2-ylmethyl)methanesulfonamide","1-(3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo(4,5)cyclohepta(1,2-b)pyridin-7-yl)-N-(pyridin-2-ylmethyl)methanesulfonamide","C581209","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23467907","A novel c-Met inhibitor, MK8033, synergizes with carboplatin plus paclitaxel to inhibit ovarian cancer cell growth.","23467907",136]
["1-(3-(2-(1-benzothiophen-5-yl) ethoxy) propyl)-3-azetidinol maleate","1-(3-(2-(1-benzothiophen-5-yl) ethoxy) propyl)-3-azetidinol maleate","C503102","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2006,"16219389","T-817MA, a novel neurotrophic agent, improves sodium nitroprusside-induced mitochondrial dysfunction in cortical neurons.","16219389",136]
["1-(3-(2-(1-benzothiophen-5-yl) ethoxy) propyl)-3-azetidinol maleate","1-(3-(2-(1-benzothiophen-5-yl) ethoxy) propyl)-3-azetidinol maleate","C503102","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Atrophy","D001284","Atrophy",1,1,2014,"24112791","Effects of the neurotrophic agent T-817MA on oligomeric amyloid-β-induced deficits in long-term potentiation in the hippocampal CA1 subfield.","24112791",136]
["1-(3-(2-(1-benzothiophen-5-yl) ethoxy) propyl)-3-azetidinol maleate","1-(3-(2-(1-benzothiophen-5-yl) ethoxy) propyl)-3-azetidinol maleate","C503102","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"19371351","T-817MA, a neurotrophic agent, ameliorates the deficits in adult neurogenesis and spatial memory in rats infused i.c.v. with amyloid-beta peptide.","19371351",136]
["1-(3-(2H-1,2,3-triazol-2-yl)phenyl)-N-6-(2-aminocyclohexyl)-1H-pyrazolo(3,4-b)pyrazine-3,6-diamine","1-(3-(2H-1,2,3-triazol-2-yl)phenyl)-N-6-(2-aminocyclohexyl)-1H-pyrazolo(3,4-b)pyrazine-3,6-diamine","C000620493","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27264434","3-aminopyrazolopyrazine derivatives as spleen tyrosine kinase inhibitors.","27264434",136]
["1-(3-(2-methylpyridin-4-yl)-1H-pyrazolo(4,3-c)pyridin-6-yl)-3-(1-phenylethyl)urea","1-(3-(2-methylpyridin-4-yl)-1H-pyrazolo(4,3-c)pyridin-6-yl)-3-(1-phenylethyl)urea","C000619474","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27329786","Discovery of 1-(1H-Pyrazolo[4,3-c]pyridin-6-yl)urea Inhibitors of Extracellular Signal-Regulated Kinase (ERK) for the Treatment of Cancers.","27329786",136]
["1-(3-(3-(3,4,5-trimethoxybenzoyl)-1H-pyrrol-1-yl)phenyl)guanidine","1-(3-(3-(3,4,5-trimethoxybenzoyl)-1H-pyrrol-1-yl)phenyl)guanidine","C000594995","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"25025991","New pyrrole derivatives with potent tubulin polymerization inhibiting activity as anticancer agents including hedgehog-dependent cancer.","25025991",136]
["1-(3-(3,4,5-trimethoxyphenyl)acryloyl)piperidin-2-one","1-(3-(3,4,5-trimethoxyphenyl)acryloyl)piperidin-2-one","C000601731","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"26079183","Synthesis of piperlongumine analogues and discovery of nuclear factor erythroid 2-related factor 2 (Nrf2) activators as potential neuroprotective agents.","26079183",136]
["1-(3-(3,4,5-trimethoxyphenyl)acryloyl)piperidin-2-one","1-(3-(3,4,5-trimethoxyphenyl)acryloyl)piperidin-2-one","C000601731","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"26079183","Synthesis of piperlongumine analogues and discovery of nuclear factor erythroid 2-related factor 2 (Nrf2) activators as potential neuroprotective agents.","26079183",136]
["1-(3-(3-aminopropylamino)-2-hydroxylpropylamino)-9,10-anthraquinone","1-(3-(3-aminopropylamino)-2-hydroxylpropylamino)-9,10-anthraquinone","C579330","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22913275","Synthesis, cytotoxicity, and cell death profile of polyaminoanthraquinones as antitumor agents.","22913275",136]
["1-(3-(4-aminobutylamino)-2-hydroxylpropylamino)-9,10-anthraquinone","1-(3-(4-aminobutylamino)-2-hydroxylpropylamino)-9,10-anthraquinone","C579331","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22913275","Synthesis, cytotoxicity, and cell death profile of polyaminoanthraquinones as antitumor agents.","22913275",136]
["1-(3-(4-methoxyphenyl)acryloyl)pyrrolidin-2-one","1-(3-(4-methoxyphenyl)acryloyl)pyrrolidin-2-one","C000601732","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"26079183","Synthesis of piperlongumine analogues and discovery of nuclear factor erythroid 2-related factor 2 (Nrf2) activators as potential neuroprotective agents.","26079183",136]
["1-(3-(4-methoxyphenyl)acryloyl)pyrrolidin-2-one","1-(3-(4-methoxyphenyl)acryloyl)pyrrolidin-2-one","C000601732","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"26079183","Synthesis of piperlongumine analogues and discovery of nuclear factor erythroid 2-related factor 2 (Nrf2) activators as potential neuroprotective agents.","26079183",136]
["1-(3-(4-tert-butylphenoxy)propyl)piperidine","1-(3-(4-tert-butylphenoxy)propyl)piperidine","C000608066","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2015,"25869247","Pharmacokinetics and tissue distribution of the new non-imidazole histamine H3 receptor antagonist 1-[3-(4-tert-butylphenoxy) propyl]piperidine in rats.","25869247",136]
["1-(3-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)propyl)-4-(2-(3-fluorophenyl)ethyl)piperazine","1-(3-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)propyl)-4-(2-(3-fluorophenyl)ethyl)piperazine","C117663","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2000,"10659950","Interspecies comparison and role of human cytochrome P450 and flavin-containing monooxygenase in hepatic metabolism of L-775,606, a potent 5-HT(1D) receptor agonist.","10659950",136]
["1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea","1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea","C575620","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22168626","Identification of 1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea hydrochloride (CEP-32496), a highly potent and orally efficacious inhibitor of V-RAF murine sarcoma viral oncogene homologue B1 (BRAF) V600E.","22168626",136]
["1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea","1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea","C575620","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2012,"22319199","CEP-32496: a novel orally active BRAF(V600E) inhibitor with selective cellular and in vivo antitumor activity.","22319199",136]
["1-(3',4',5'-trimethoxy)phenylnaphtho(2,1b)furan","1-(3',4',5'-trimethoxy)phenylnaphtho(2,1b)furan","C509743","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2006,"16297622","Synthesis of 1-(3',4',5'-trimethoxy) phenyl naphtho[2,1b]furan as a novel anticancer agent.","16297622",136]
["1-(3',4',5'-trimethoxyphenyl)-2-nitroethylene","1-(3',4',5'-trimethoxyphenyl)-2-nitroethylene","C462659","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2002,"12000503","Antifungal and cancer cell growth inhibitory activities of 1-(3',4',5'-trimethoxyphenyl)-2-nitro-ethylene.","12000503",136]
["1-(3',4',5'-trimethoxyphenyl)-3-(3'',4''-dimethoxy-2'-hydroxyphenyl)propane","1-(3',4',5'-trimethoxyphenyl)-3-(3'',4''-dimethoxy-2'-hydroxyphenyl)propane","C552420","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"20674558","1-(3',4',5'-Trimethoxyphenyl)-3-(3'',4''-dimethoxy-2''-hydroxyphenyl)-propane with microtubule-depolymerizing ability induces G2/M phase arrest and apoptosis in HepG2 cells.","20674558",136]
["1-(3,4,5-trimethoxyphenyl)-5-(4-ethoxyphenyl)-1H-1,2,4-triazole","1-(3,4,5-trimethoxyphenyl)-5-(4-ethoxyphenyl)-1H-1,2,4-triazole","C550171","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2010,"20420439","Synthesis and antitumor activity of 1,5-disubstituted 1,2,4-triazoles as cis-restricted combretastatin analogues.","20420439",136]
["1-(3,4,5-trimethoxyphenyl)-5-(4-ethoxyphenyl)-1H-tetrazole","1-(3,4,5-trimethoxyphenyl)-5-(4-ethoxyphenyl)-1H-tetrazole","C570919","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22136312","Synthesis and evaluation of 1,5-disubstituted tetrazoles as rigid analogues of combretastatin A-4 with potent antiproliferative and antitumor activity.","22136312",136]
["1-(3,4,5-trimethoxyphenyl)-5-(4-ethoxyphenyl)-1H-tetrazole","1-(3,4,5-trimethoxyphenyl)-5-(4-ethoxyphenyl)-1H-tetrazole","C570919","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22136312","Synthesis and evaluation of 1,5-disubstituted tetrazoles as rigid analogues of combretastatin A-4 with potent antiproliferative and antitumor activity.","22136312",136]
["1-(3',4'-dichloro-2-fluoro(1,1'-biphenyl)-4-yl)cyclopropanecarboxylic acid","1-(3',4'-dichloro-2-fluoro(1,1'-biphenyl)-4-yl)cyclopropanecarboxylic acid","C522246","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24938499","CHF5074 protects SH-SY5Y human neuronal-like cells from amyloidbeta 25-35 and tumor necrosis factor related apoptosis inducing ligand toxicity in vitro.","24938499",136]
["1-(3',4'-dichloro-2-fluoro(1,1'-biphenyl)-4-yl)cyclopropanecarboxylic acid","1-(3',4'-dichloro-2-fluoro(1,1'-biphenyl)-4-yl)cyclopropanecarboxylic acid","C522246","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28106772","Neuroprotective and Anti-Apoptotic Effects of CSP-1103 in Primary Cortical Neurons Exposed to Oxygen and Glucose Deprivation.","28106772",136]
["1-(3',4'-dichloro-2-fluoro(1,1'-biphenyl)-4-yl)cyclopropanecarboxylic acid","1-(3',4'-dichloro-2-fluoro(1,1'-biphenyl)-4-yl)cyclopropanecarboxylic acid","C522246","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2017,"28106772","Neuroprotective and Anti-Apoptotic Effects of CSP-1103 in Primary Cortical Neurons Exposed to Oxygen and Glucose Deprivation.","28106772",136]
["1-(3,4-dichlorophenyl)acetyl-2-(1-pyrrolidinyl)methylpiperidine","1-(3,4-dichlorophenyl)acetyl-2-(1-pyrrolidinyl)methylpiperidine","C454101","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23996400","Neuroprotection by the kappa-opioid receptor agonist, BRL52537, is mediated via up-regulating phosphorylated signal transducer and activator of transcription-3 in cerebral ischemia/reperfusion injury in rats.","23996400",136]
["1-(3,4-dihydroxyphenyl)-2-((1-mesityl-1H-imidazo(4,5-c)pyridin-2-yl)thio)ethanone","1-(3,4-dihydroxyphenyl)-2-((1-mesityl-1H-imidazo(4,5-c)pyridin-2-yl)thio)ethanone","C000595838","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24922544","Discovery and characterization of novel imidazopyridine derivative CHEQ-2 as a potent CDC25 inhibitor and promising anticancer drug candidate.","24922544",136]
["1-(3,4-dihydroxyphenyl)-2-thiocyanate-ethanone","1-(3,4-dihydroxyphenyl)-2-thiocyanate-ethanone","C527742","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2008,"18049481","A molecular chaperone inducer protects neurons from ER stress.","18049481",136]
["1-(3,4-dihydroxyphenyl)-2-thiocyanate-ethanone","1-(3,4-dihydroxyphenyl)-2-thiocyanate-ethanone","C527742","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2009,"18757512","Effect of an inducer of BiP, a molecular chaperone, on endoplasmic reticulum (ER) stress-induced retinal cell death.","18757512",136]
["1-(3,4-dihydroxyphenyl)-2-thiocyanate-ethanone","1-(3,4-dihydroxyphenyl)-2-thiocyanate-ethanone","C527742","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"20709152","Post-treatment of a BiP inducer prevents cell death after middle cerebral artery occlusion in mice.","20709152",136]
["1-(3,4-dihydroxyphenyl)-3-(2-methoxyphenyl)prop-2-en-1-one","1-(3,4-dihydroxyphenyl)-3-(2-methoxyphenyl)prop-2-en-1-one","C000603962","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"26552551","Chemopreventive effect of chalcone derivative, L2H17, in colon cancer development.","26552551",136]
["1-(3,4-dihydroxystyryl)-3-(4-hydroxyphenethyl)urea","1-(3,4-dihydroxystyryl)-3-(4-hydroxyphenethyl)urea","C550461","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24905050","A phenolic acid phenethyl urea derivative protects against irradiation-induced osteoblast damage by modulating intracellular redox state.","24905050",136]
["1-(3,4-dimethoxybenzyl)-5-(2-(methylsulfonyl)-6-(trifluoromethyl)pyrimidin-4-yl)pyridin-2(1H)-one","1-(3,4-dimethoxybenzyl)-5-(2-(methylsulfonyl)-6-(trifluoromethyl)pyrimidin-4-yl)pyridin-2(1H)-one","C000622061","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27447985","A Small Molecule That Protects the Integrity of the Electron Transfer Chain Blocks the Mitochondrial Apoptotic Pathway.","27447985",136]
["1-(3,4-dimethoxybenzyl)-5-(2-(methylsulfonyl)-6-(trifluoromethyl)pyrimidin-4-yl)pyridin-2(1H)-one","1-(3,4-dimethoxybenzyl)-5-(2-(methylsulfonyl)-6-(trifluoromethyl)pyrimidin-4-yl)pyridin-2(1H)-one","C000622061","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27447985","A Small Molecule That Protects the Integrity of the Electron Transfer Chain Blocks the Mitochondrial Apoptotic Pathway.","27447985",136]
["1-(3,4-dimethoxyphenyl)-3-(9H-pyrido(3,4-b)indol-1-yl)prop-2-en-1-one","1-(3,4-dimethoxyphenyl)-3-(9H-pyrido(3,4-b)indol-1-yl)prop-2-en-1-one","C000622459","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27543608","Dual targeting of MDM2 with a novel small-molecule inhibitor overcomes TRAIL resistance in cancer.","27543608",136]
["1-(3,5-bis(trifluoromethyl)phenyl)-3-(4-bromo-2-(1H-tetrazol-5-yl)phenyl)thiourea","1-(3,5-bis(trifluoromethyl)phenyl)-3-(4-bromo-2-(1H-tetrazol-5-yl)phenyl)thiourea","C524410","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"26163046","Activation of large-conductance Ca(2+)-activated K(+) channels inhibits glutamate-induced oxidative stress through attenuating ER stress and mitochondrial dysfunction.","26163046",136]
["1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl-)-1-pentanone","1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl-)-1-pentanone","C055365","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1989,"2466719","Studies on the accumulation of the differentiation-inducing factor (DIF) in high-cell-density monolayers of Dictyostelium discoideum.","2466719",136]
["1-(3',5'-dihydroxyphenoxy)-7-(2'',4'',6''-trihydroxyphenoxy)-2,4,9-trihydroxydibenzo-1,4,-dioxin","1-(3',5'-dihydroxyphenoxy)-7-(2'',4'',6''-trihydroxyphenoxy)-2,4,9-trihydroxydibenzo-1,4,-dioxin","C540360","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"19330880","Differentiation of human osteosarcoma cells by isolated phlorotannins is subtly linked to COX-2, iNOS, MMPs, and MAPK signaling: implication for chronic articular disease.","19330880",136]
["1-(3'-aminopropyl)-3-hydroxy-2-methyl-4-pyridinone","1-(3'-aminopropyl)-3-hydroxy-2-methyl-4-pyridinone","C415336","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2000,"10857911","Synthesis, chelating properties towards gallium and biological evaluation of two N-substituted 3-hydroxy-4-pyridinones.","10857911",136]
["1-(3-aminopropyl)imidazole","1-(3-aminopropyl)imidazole","C515394","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2006,"16967481","Phase transition behavior of novel pH-sensitive polyaspartamide derivatives grafted with 1-(3-aminopropyl)imidazole.","16967481",136]
["1-(3-aminopropyl)imidazole","1-(3-aminopropyl)imidazole","C515394","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2010,"21137839","Effect of hydrophobic octadecyl groups on pH-sensitive aggregation behavior of imidazole-containing polyaspartammide derivatives.","21137839",136]
["1-(3-aminopropyl)imidazole","1-(3-aminopropyl)imidazole","C515394","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2017,"27889588","Preparation and properties evaluation of a novel pH-sensitive liposomes based on imidazole-modified cholesterol derivatives.","27889588",136]
["1-(3-biphenyl-4-ylbutyl)piperidine","1-(3-biphenyl-4-ylbutyl)piperidine","C584299","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23832823","Chemical, pharmacological, and in vitro metabolic stability studies on enantiomerically pure RC-33 compounds: promising neuroprotective agents acting as σ₁ receptor agonists.","23832823",136]
["1-(3-chloro-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone","1-(3-chloro-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone","C055364","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21238462","Derivatives of Dictyostelium differentiation-inducing factors promote mitogen-activated IL-2 production via AP-1 in Jurkat cells.","21238462",136]
["1-(3-chloro-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone","1-(3-chloro-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone","C055364","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23977224","Mitochondria are the target organelle of differentiation-inducing factor-3, an anti-tumor agent isolated from Dictyostelium discoideum [corrected].","23977224",136]
["1-(3-chloro-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone","1-(3-chloro-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone","C055364","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25913757","Differentiation-inducing factor-3 inhibits intestinal tumor growth in vitro and in vivo.","25913757",136]
["1-(3-chlorophenyl)piperazine","1-(3-chlorophenyl)piperazine","C015068","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2008,"18400445","HPLC analysis of the antidepressant trazodone and its main metabolite m-CPP in human plasma.","18400445",136]
["1-(3-cyano-4-neopentyloxyphenyl)pyrazole-4-carboxylic acid","1-(3-cyano-4-neopentyloxyphenyl)pyrazole-4-carboxylic acid","C433950","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2005,"15665488","Y-700, a novel inhibitor of xanthine oxidase, suppresses the development of colon aberrant crypt foci and cell proliferation in 1,2-dimethylhydrazine-treated mice.","15665488",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C1027,B1027)","v":"1-(3-hydroxy-6-(hydroxymethyl)-4-oxopyridyl)-2-ethanesulfonic acid"},"1-(3-hydroxy-6-(hydroxymethyl)-4-oxopyridyl)-2-ethanesulfonic acid","C085370","1_MIE",867,1,"Intracellular pH","Decrease",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J1027,K1027)","v":"Hydrogen-Ion Concentration"},"D006863","Hydrogen-Ion Concentration",2,2,1994,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q1027,Q1027)","v":"8289206"},"Enhancement of iron excretion via monoanionic 3-hydroxypyrid-4-ones.","8289206",136]
["1-(3-sulfonatopropyl)-4-(beta)(2-(di-n-butylamino)-6-naphthylvinyl)pyridinium betaine","1-(3-sulfonatopropyl)-4-(beta)(2-(di-n-butylamino)-6-naphthylvinyl)pyridinium betaine","C050019","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2016,"26597957","Fluorescence-Based Automated Screening Assay for the Study of the pH-Sensitive Channel ASIC1a.","26597957",136]
["1-(3-trifluoromethylphenyl)piperazine","1-(3-trifluoromethylphenyl)piperazine","C018406","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"27358233","In vitro hepatotoxicity of 'Legal X': the combination of 1-benzylpiperazine (BZP) and 1-(m-trifluoromethylphenyl)piperazine (TFMPP) triggers oxidative stress, mitochondrial impairment and apoptosis.","27358233",136]
["1-(3-trifluoromethylphenyl)piperazine","1-(3-trifluoromethylphenyl)piperazine","C018406","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"23026265","Estrogenic effects and their action mechanism of the major active components of party pill drugs.","23026265",136]
["1-(3-trifluoromethylphenyl)piperazine","1-(3-trifluoromethylphenyl)piperazine","C018406","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2013,"23861339","Stability of 3,4-methylenedioxymethampetamine (MDMA), 4-methylmethcathinone (mephedrone) and 3-trifluromethylphenylpiperazine (3-TFMPP) in formalin solution.","23861339",136]
["1-(4-((1H-pyrazolo(3,4-d)pyrimidin-4-yl)oxy)-2-fluorophenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea","1-(4-((1H-pyrazolo(3,4-d)pyrimidin-4-yl)oxy)-2-fluorophenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea","C000593421","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2014,"24789676","A preclinical evaluation of a novel multikinase inhibitor, SKLB-329, as a therapeutic agent against hepatocellular carcinoma.","24789676",136]
["1-(4-((1H-pyrazolo(3,4-d)pyrimidin-4-yl)oxy)-2-fluorophenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea","1-(4-((1H-pyrazolo(3,4-d)pyrimidin-4-yl)oxy)-2-fluorophenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea","C000593421","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2014,"24789676","A preclinical evaluation of a novel multikinase inhibitor, SKLB-329, as a therapeutic agent against hepatocellular carcinoma.","24789676",136]
["1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno(3,2-d)pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one","1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno(3,2-d)pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one","C569670","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"25285629","GDC-0980-induced apoptosis is enhanced by autophagy inhibition in human pancreatic cancer cells.","25285629",136]
["1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno(3,2-d)pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one","1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno(3,2-d)pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one","C569670","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25950487","Inhibition of autophagy sensitizes malignant pleural mesothelioma cells to dual PI3K/mTOR inhibitors.","25950487",136]
["1-(4-((3-(4-methylpiperazin-1-yl)propyl)amino)benzyl)-5-(trifluoromethyl)pyridin-2(1H)-one","1-(4-((3-(4-methylpiperazin-1-yl)propyl)amino)benzyl)-5-(trifluoromethyl)pyridin-2(1H)-one","C000607330","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"26042668","Mefunidone attenuates tubulointerstitial fibrosis in a rat model of unilateral ureteral obstruction.","26042668",136]
["1-(4-((4-(dimethylamino)piperidin-1-yl)carbonyl)phenyl)-3-(4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl)urea","1-(4-((4-(dimethylamino)piperidin-1-yl)carbonyl)phenyl)-3-(4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl)urea","C549060","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24823695","The dual PI3K/mTOR inhibitor PKI-587 enhances sensitivity to cetuximab in EGFR-resistant human head and neck cancer models.","24823695",136]
["1-(4-((4-(dimethylamino)piperidin-1-yl)carbonyl)phenyl)-3-(4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl)urea","1-(4-((4-(dimethylamino)piperidin-1-yl)carbonyl)phenyl)-3-(4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl)urea","C549060","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25504751","Dual PI3K/mTOR inhibitors, GSK2126458 and PKI-587, suppress tumor progression and increase radiosensitivity in nasopharyngeal carcinoma.","25504751",136]
["1-(4-((4-(dimethylamino)piperidin-1-yl)carbonyl)phenyl)-3-(4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl)urea","1-(4-((4-(dimethylamino)piperidin-1-yl)carbonyl)phenyl)-3-(4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl)urea","C549060","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"26999641","Aberrant activation of the PI3K/mTOR pathway promotes resistance to sorafenib in AML.","26999641",136]
["1-(4-((4-(dimethylamino)piperidin-1-yl)carbonyl)phenyl)-3-(4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl)urea","1-(4-((4-(dimethylamino)piperidin-1-yl)carbonyl)phenyl)-3-(4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl)urea","C549060","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"27513674","Inhibition of mTOR's Catalytic Site by PKI-587 Is a Promising Therapeutic Option for Gastroenteropancreatic Neuroendocrine Tumor Disease.","27513674",136]
["1-(4-((4-(dimethylamino)piperidin-1-yl)carbonyl)phenyl)-3-(4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl)urea","1-(4-((4-(dimethylamino)piperidin-1-yl)carbonyl)phenyl)-3-(4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl)urea","C549060","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23769634","PKI-587 and sorafenib alone and in combination on inhibition of liver cancer stem cell proliferation.","23769634",136]
["1-(4-((4-(dimethylamino)piperidin-1-yl)carbonyl)phenyl)-3-(4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl)urea","1-(4-((4-(dimethylamino)piperidin-1-yl)carbonyl)phenyl)-3-(4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl)urea","C549060","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24823695","The dual PI3K/mTOR inhibitor PKI-587 enhances sensitivity to cetuximab in EGFR-resistant human head and neck cancer models.","24823695",136]
["1-(4-((4-(dimethylamino)piperidin-1-yl)carbonyl)phenyl)-3-(4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl)urea","1-(4-((4-(dimethylamino)piperidin-1-yl)carbonyl)phenyl)-3-(4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl)urea","C549060","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25504751","Dual PI3K/mTOR inhibitors, GSK2126458 and PKI-587, suppress tumor progression and increase radiosensitivity in nasopharyngeal carcinoma.","25504751",136]
["1-(4-((4-(dimethylamino)piperidin-1-yl)carbonyl)phenyl)-3-(4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl)urea","1-(4-((4-(dimethylamino)piperidin-1-yl)carbonyl)phenyl)-3-(4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl)urea","C549060","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25977343","MEK Inhibitor PD-0325901 Overcomes Resistance to PI3K/mTOR Inhibitor PF-5212384 and Potentiates Antitumor Effects in Human Head and Neck Squamous Cell Carcinoma.","25977343",136]
["1-(4-((4-(dimethylamino)piperidin-1-yl)carbonyl)phenyl)-3-(4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl)urea","1-(4-((4-(dimethylamino)piperidin-1-yl)carbonyl)phenyl)-3-(4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl)urea","C549060","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"26956874","Structural insights of a PI3K/mTOR dual inhibitor with the morpholino-triazine scaffold.","26956874",136]
["1-(4-((4-(dimethylamino)piperidin-1-yl)carbonyl)phenyl)-3-(4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl)urea","1-(4-((4-(dimethylamino)piperidin-1-yl)carbonyl)phenyl)-3-(4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl)urea","C549060","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"26999641","Aberrant activation of the PI3K/mTOR pathway promotes resistance to sorafenib in AML.","26999641",136]
["1-(4-((4-(dimethylamino)piperidin-1-yl)carbonyl)phenyl)-3-(4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl)urea","1-(4-((4-(dimethylamino)piperidin-1-yl)carbonyl)phenyl)-3-(4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl)urea","C549060","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28159681","The dual specificity PI3K/mTOR inhibitor PKI-587 displays efficacy against T-cell acute lymphoblastic leukemia (T-ALL).","28159681",136]
["1-(4-(1H-1,2,4-triazol-1-yl)benzylidene)-2-(4-(4-nitrophenyl)thiazol-2-yl)hydrazine","1-(4-(1H-1,2,4-triazol-1-yl)benzylidene)-2-(4-(4-nitrophenyl)thiazol-2-yl)hydrazine","C000596312","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24631185","Synthesis and antimycobacterial activities of some new thiazolylhydrazone derivatives.","24631185",136]
["1-(4-(1H-benzo(d)imidazol-2-yl)phenyl)-9H-pyrido(3,4-b)indole","1-(4-(1H-benzo(d)imidazol-2-yl)phenyl)-9H-pyrido(3,4-b)indole","C000616874","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28171832","Design and synthesis of novel phenyl -1, 4-beta-carboline-hybrid molecules as potential anticancer agents.","28171832",136]
["1-(4-(1H-pyrazolo(3,4-d)pyrimidin-4-yloxy)-3-fluorophenyl)-3-(5-tert-butylisoxazol-3-yl)urea","1-(4-(1H-pyrazolo(3,4-d)pyrimidin-4-yloxy)-3-fluorophenyl)-3-(5-tert-butylisoxazol-3-yl)urea","C000610642","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"26497577","SKLB-677, an FLT3 and Wnt/β-catenin signaling inhibitor, displays potent activity in models of FLT3-driven AML.","26497577",136]
["1-(4-(1H-pyrazolo(3,4-d)pyrimidin-4-yloxy)-3-fluorophenyl)-3-(5-tert-butylisoxazol-3-yl)urea","1-(4-(1H-pyrazolo(3,4-d)pyrimidin-4-yloxy)-3-fluorophenyl)-3-(5-tert-butylisoxazol-3-yl)urea","C000610642","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"26497577","SKLB-677, an FLT3 and Wnt/β-catenin signaling inhibitor, displays potent activity in models of FLT3-driven AML.","26497577",136]
["1-(4-(1H-pyrazolo(3,4-d)pyrimidin-4-yloxy)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea","1-(4-(1H-pyrazolo(3,4-d)pyrimidin-4-yloxy)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea","C582543","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23362959","Structure-activity relationship studies of pyrazolo[3,4-d]pyrimidine derivatives leading to the discovery of a novel multikinase inhibitor that potently inhibits FLT3 and VEGFR2 and evaluation of its activity against acute myeloid leukemia in vitro and in vivo.","23362959",136]
["1-(4-(1H-pyrazolo(3,4-d)pyrimidin-4-yloxy)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea","1-(4-(1H-pyrazolo(3,4-d)pyrimidin-4-yloxy)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea","C582543","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23362959","Structure-activity relationship studies of pyrazolo[3,4-d]pyrimidine derivatives leading to the discovery of a novel multikinase inhibitor that potently inhibits FLT3 and VEGFR2 and evaluation of its activity against acute myeloid leukemia in vitro and in vivo.","23362959",136]
["1-(4-(1H-pyrazolo(3,4-d)pyrimidin-4-yloxy)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea","1-(4-(1H-pyrazolo(3,4-d)pyrimidin-4-yloxy)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea","C582543","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23867251","SC-535, a novel oral multikinase inhibitor, showed potent antitumor activity in human melanoma models.","23867251",136]
["1-(4-(2-ethoxy-4-methyl-1H-pyrrol-1-yl)-3-hydroxy-2,2-dimethylchroman-6-yl)-3-phenylurea","1-(4-(2-ethoxy-4-methyl-1H-pyrrol-1-yl)-3-hydroxy-2,2-dimethylchroman-6-yl)-3-phenylurea","C569385","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"21833470","A novel cromakalim analogue induces cell cycle arrest and apoptosis in human cervical carcinoma HeLa cells through the caspase- and mitochondria-dependent pathway.","21833470",136]
["1-(4-(2-ethoxy-4-methyl-1H-pyrrol-1-yl)-3-hydroxy-2,2-dimethylchroman-6-yl)-3-phenylurea","1-(4-(2-ethoxy-4-methyl-1H-pyrrol-1-yl)-3-hydroxy-2,2-dimethylchroman-6-yl)-3-phenylurea","C569385","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21833470","A novel cromakalim analogue induces cell cycle arrest and apoptosis in human cervical carcinoma HeLa cells through the caspase- and mitochondria-dependent pathway.","21833470",136]
["1-(4-(2-fluoroethoxy)benzyl)-5-(1-(2-methoxymethylpyrrolidinyl)sulfonyl)isatin","1-(4-(2-fluoroethoxy)benzyl)-5-(1-(2-methoxymethylpyrrolidinyl)sulfonyl)isatin","C516218","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2006,"17154501","5-pyrrolidinylsulfonyl isatins as a potential tool for the molecular imaging of caspases in apoptosis.","17154501",136]
["1-(4-(2-fluoroethoxy)benzyl)-5-(1-(2-methoxymethylpyrrolidinyl)sulfonyl)isatin","1-(4-(2-fluoroethoxy)benzyl)-5-(1-(2-methoxymethylpyrrolidinyl)sulfonyl)isatin","C516218","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2007,"17372575","The nonpeptidyl caspase binding radioligand (S)-1-(4-(2-[18F]Fluoroethoxy)-benzyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin ([18F]CbR) as potential positron emission tomography-compatible apoptosis imaging agent.","17372575",136]
["1-(4-(4-(aminosulfonyl)phenyl)-1H-1,2,3-triazole)-2,3,4-tri-O-acetyl-6-O-(((bis((2-((2,2-dimethylpropionyl)sulfanyl)ethoxy))phosphoryloxy)ethyl))glucopyranoside","1-(4-(4-(aminosulfonyl)phenyl)-1H-1,2,3-triazole)-2,3,4-tri-O-acetyl-6-O-(((bis((2-((2,2-dimethylpropionyl)sulfanyl)ethoxy))phosphoryloxy)ethyl))glucopyranoside","C000603805","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2015,"26347950","Phosphate Chemical Probes Designed for Location Specific Inhibition of Intracellular Carbonic Anhydrases.","26347950",136]
["1-(4-(4-fluorophenyl)piperazine-1-yl)-3-(2-oxopyrrolidin-1-yl)propane","1-(4-(4-fluorophenyl)piperazine-1-yl)-3-(2-oxopyrrolidin-1-yl)propane","C439505","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2003,"12946528","Assay method for quality control and stability studies of a new CVS disorder agent (compound 93/478).","12946528",136]
["1-(4-(4-fluorophenyl)piperazine-1-yl)-3-(2-oxopyrrolidin-1-yl)propane","1-(4-(4-fluorophenyl)piperazine-1-yl)-3-(2-oxopyrrolidin-1-yl)propane","C439505","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2008,"18412019","Absorption, protein binding, pharmacokinetics and excretion of the anti-ischemic and anti-hypertensive arylpiperazine derivative CDRI-93/478 in rats.","18412019",136]
["1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one","1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one","C553294","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"24185040","Selective targeting of human colon cancer stem-like cells by the mTOR inhibitor Torin-1.","24185040",136]
["1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one","1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one","C553294","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28918901","mTOR Inhibition Restores Amino Acid Balance in Cells Dependent on Catabolism of Extracellular Protein.","28918901",136]
["1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one","1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one","C553294","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2013,"24185040","Selective targeting of human colon cancer stem-like cells by the mTOR inhibitor Torin-1.","24185040",136]
["1-(4-(5,6,7,8-tetrahydronaphthyloxy)phenyl)-1-hydroxymethylphosphonic acid","1-(4-(5,6,7,8-tetrahydronaphthyloxy)phenyl)-1-hydroxymethylphosphonic acid","C116525","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,1,1998,"9839016","Inhibition of myo-inositol monophosphatase isoforms by aromatic phosphonates.","9839016",136]
["1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone","1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone","C517943","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"21521748","Insulinotropic and antidiabetic effects of 17β-estradiol and the GPR30 agonist G-1 on human pancreatic islets.","21521748",136]
["1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone","1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone","C517943","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25204801","The GPER agonist G-1 induces mitotic arrest and apoptosis in human vascular smooth muscle cells independent of GPER.","25204801",136]
["1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone","1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone","C517943","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25724739","G protein-coupled estrogen receptor 1 agonist G-1 induces cell cycle arrest in the mitotic phase, leading to apoptosis in endometriosis.","25724739",136]
["1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone","1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone","C517943","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25744245","G protein-coupled estrogen receptor (GPER) mediates NSCLC progression induced by 17β-estradiol (E2) and selective agonist G1.","25744245",136]
["1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone","1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone","C517943","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25813290","Are we facing a potential effective treatment for endometriosis?","25813290",136]
["1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone","1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone","C517943","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25936661","Activation of novel estrogen receptor GPER results in inhibition of cardiocyte apoptosis and cardioprotection.","25936661",136]
["1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone","1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone","C517943","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"26131713","GPER agonist G-1 decreases adrenocortical carcinoma (ACC) cell growth in vitro and in vivo.","26131713",136]
["1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone","1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone","C517943","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27407175","G-1 exerts neuroprotective effects through G protein-coupled estrogen receptor 1 following spinal cord injury in mice.","27407175",136]
["1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone","1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone","C517943","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28258163","G-1 Inhibits Breast Cancer Cell Growth via Targeting Colchicine-Binding Site of Tubulin to Interfere with Microtubule Assembly.","28258163",136]
["1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone","1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone","C517943","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21273787","The GPER1 agonist G-1 attenuates endothelial cell proliferation by inhibiting DNA synthesis and accumulating cells in the S and G2 phases of the cell cycle.","21273787",136]
["1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone","1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone","C517943","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21722102","Induction of interleukin-10 in the T helper type 17 effector population by the G protein coupled estrogen receptor (GPER) agonist G-1.","21722102",136]
["1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone","1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone","C517943","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2012,"22451019","The G protein-coupled oestrogen receptor 1 agonist G-1 disrupts endothelial cell microtubule structure in a receptor-independent manner.","22451019",136]
["1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone","1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone","C517943","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22468845","Effects of a combined treatment with GPR30 agonist G-1 and herceptin on growth and gene expression of human breast cancer cell lines.","22468845",136]
["1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone","1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone","C517943","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23840305","Activation of GPER Induces Differentiation and Inhibition of Coronary Artery Smooth Muscle Cell Proliferation.","23840305",136]
["1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone","1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone","C517943","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23921077","G protein-coupled estrogen receptor (GPER) expression in endometrial adenocarcinoma and effect of agonist G-1 on growth of endometrial adenocarcinoma cell lines.","23921077",136]
["1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone","1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone","C517943","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24446390","A novel estrogen receptor GPER mediates proliferation induced by 17β-estradiol and selective GPER agonist G-1 in estrogen receptor α (ERα)-negative ovarian cancer cells.","24446390",136]
["1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone","1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone","C517943","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25204801","The GPER agonist G-1 induces mitotic arrest and apoptosis in human vascular smooth muscle cells independent of GPER.","25204801",136]
["1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone","1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone","C517943","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"25287069","Targeting GPR30 with G-1: a new therapeutic target for castration-resistant prostate cancer.","25287069",136]
["1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone","1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone","C517943","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25724739","G protein-coupled estrogen receptor 1 agonist G-1 induces cell cycle arrest in the mitotic phase, leading to apoptosis in endometriosis.","25724739",136]
["1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone","1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone","C517943","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25744245","G protein-coupled estrogen receptor (GPER) mediates NSCLC progression induced by 17β-estradiol (E2) and selective agonist G1.","25744245",136]
["1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone","1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone","C517943","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25813290","Are we facing a potential effective treatment for endometriosis?","25813290",136]
["1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone","1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone","C517943","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"26131713","GPER agonist G-1 decreases adrenocortical carcinoma (ACC) cell growth in vitro and in vivo.","26131713",136]
["1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone","1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone","C517943","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28258163","G-1 Inhibits Breast Cancer Cell Growth via Targeting Colchicine-Binding Site of Tubulin to Interfere with Microtubule Assembly.","28258163",136]
["1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone","1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone","C517943","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28947257","The activation of the G protein-coupled estrogen receptor (GPER) inhibits the proliferation of mouse melanoma K1735-M2 cells.","28947257",136]
["1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone","1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone","C517943","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2017,"27836733","Activation of GPER suppresses migration and angiogenesis of triple negative breast cancer via inhibition of NF-κB/IL-6 signals.","27836733",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C1091,B1091)","v":"1-(4-(6-chloro-7-(2-fluorophenyl)quinazolin-4-yl)piperazin-1-yl)prop-2-en-1-one"},"1-(4-(6-chloro-7-(2-fluorophenyl)quinazolin-4-yl)piperazin-1-yl)prop-2-en-1-one","C000623134","5_KE",768,5,"Cytotoxicity","Increase",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J1091,K1091)","v":"Apoptosis"},"D017209","Apoptosis",1,2,2017,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q1091,Q1091)","v":"28781124"},"Potent and Selective Covalent Quinazoline Inhibitors of KRAS G12C.","28781124",136]
["1-(4-(benzo(d)(1,3)dioxol-5-ylmethyl)piperazin-1-yl)-5-(1,2-dithiolan-3-yl)pentan-1-one","1-(4-(benzo(d)(1,3)dioxol-5-ylmethyl)piperazin-1-yl)-5-(1,2-dithiolan-3-yl)pentan-1-one","C569199","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21771623","Effects of a new synthetic butyrylcholinesterase inhibitor, HBU-39, on cell proliferation and neuroblast differentiation in the hippocampal dentate gyrus in a scopolamine-induced amnesia animal model.","21771623",136]
["1-(4'-(dimethylamino)-5-hydroxy-(1,1'-biphenyl)-3-yl)-4-(2-(2-ethoxyphenyl)hydrazono)-3-methyl-1H-pyrazol-5(4H)-one","1-(4'-(dimethylamino)-5-hydroxy-(1,1'-biphenyl)-3-yl)-4-(2-(2-ethoxyphenyl)hydrazono)-3-methyl-1H-pyrazol-5(4H)-one","C000598567","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25668341","Structure-based lead optimization and biological evaluation of BAX direct activators as novel potential anticancer agents.","25668341",136]
["1-(4-(ferrocenyl ethynyl)phenyl)-1-ethanone","1-(4-(ferrocenyl ethynyl)phenyl)-1-ethanone","C520373","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2006,"16966812","Electrocatalytic oxidation and highly selective voltammetric determination of L-cysteine at the surface of a 1-[4-(ferrocenyl ethynyl)phenyl]-1-ethanone modified carbon paste electrode.","16966812",136]
["1-(4-(furo(2,3-b)quinolin-4-ylamino)phenyl)ethanone","1-(4-(furo(2,3-b)quinolin-4-ylamino)phenyl)ethanone","C510259","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28068431","CIL-102-Induced Cell Cycle Arrest and Apoptosis in Colorectal Cancer Cells via Upregulation of p21 and GADD45.","28068431",136]
["1-(4-(furo(2,3-b)quinolin-4-ylamino)phenyl)ethanone","1-(4-(furo(2,3-b)quinolin-4-ylamino)phenyl)ethanone","C510259","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22683510","The inhibitory effect of CIL-102 on the growth of human astrocytoma cells is mediated by the generation of reactive oxygen species and induction of ERK1/2 MAPK.","22683510",136]
["1-(4-(furo(2,3-b)quinolin-4-ylamino)phenyl)ethanone","1-(4-(furo(2,3-b)quinolin-4-ylamino)phenyl)ethanone","C510259","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2017,"28068431","CIL-102-Induced Cell Cycle Arrest and Apoptosis in Colorectal Cancer Cells via Upregulation of p21 and GADD45.","28068431",136]
["1-(4-(furo(2,3-b)quinolin-4-ylamino)phenyl)ethanone O-2-aminoethyloxime","1-(4-(furo(2,3-b)quinolin-4-ylamino)phenyl)ethanone O-2-aminoethyloxime","C561229","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2011,"21599000","Discovery of 4-anilinofuro[2,3-b]quinoline derivatives as selective and orally active compounds against non-small-cell lung cancers.","21599000",136]
["1-(4-(trimethylamino)phenyl)-6-phenylhexa-1,3,5-triene","1-(4-(trimethylamino)phenyl)-6-phenylhexa-1,3,5-triene","C033628","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2002,"11976278","Thioridazine interacts with the membrane of mitochondria acquiring antioxidant activity toward apoptosis--potentially implicated mechanisms.","11976278",136]
["1-(4-(trimethylamino)phenyl)-6-phenylhexa-1,3,5-triene","1-(4-(trimethylamino)phenyl)-6-phenylhexa-1,3,5-triene","C033628","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2001,"11847415","Beta-estradiol effect on erythrocyte aggregation--a controlled in vitro study.","11847415",136]
["1-(4-(trimethylamino)phenyl)-6-phenylhexa-1,3,5-triene","1-(4-(trimethylamino)phenyl)-6-phenylhexa-1,3,5-triene","C033628","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2003,"12797472","Effect of aluminium on lipid peroxidation of human high density lipoproteins.","12797472",136]
["1-(4-(trimethylamino)phenyl)-6-phenylhexa-1,3,5-triene","1-(4-(trimethylamino)phenyl)-6-phenylhexa-1,3,5-triene","C033628","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1990,"2207120","Effects of culture and incubation conditions on membrane fluidity in monolayers of cultured cells measured as fluorescence anisotropy using trimethylammoniumdiphenylhexatriene (TMA-DPH).","2207120",136]
["1-(4,4-bis(4-fluorophenyl)butyl)-4-(4-fluorophenoxy)-1,2,3,6-tetrahydropyridine","1-(4,4-bis(4-fluorophenyl)butyl)-4-(4-fluorophenoxy)-1,2,3,6-tetrahydropyridine","C049269","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Atrophy","D001284","Atrophy",1,1,1986,"3487056","Parkinson-like syndrome in nonhuman primates receiving a tetrahydropyridine derivative.","3487056",136]
["1-(4,7-dimethylbenzothiazol-2-yl)-3-(3-fluoro-4-(6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinolin-4-yloxy)phenyl)urea","1-(4,7-dimethylbenzothiazol-2-yl)-3-(3-fluoro-4-(6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinolin-4-yloxy)phenyl)urea","C000614530","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27283017","Design, Synthesis, and Biological Evaluation of 4-Phenoxyquinoline Derivatives Containing Benzo[d]thiazole-2-yl Urea as c-Met Kinase Inhibitors.","27283017",136]
["1-(4-aminophenyl)methyl-3-(3-nitrophenyl)-1,3-dihydroimidazo(4,5-b)pyridine-2-one","1-(4-aminophenyl)methyl-3-(3-nitrophenyl)-1,3-dihydroimidazo(4,5-b)pyridine-2-one","C414810","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2000,"10864141","Effects of ZNC-2381, a new oral compound, on several hepatic injury models and on hepatocellular apoptosis in mice and rats.","10864141",136]
["1-(4-aminophenyl)methyl-3-(3-nitrophenyl)-1,3-dihydroimidazo(4,5-b)pyridine-2-one","1-(4-aminophenyl)methyl-3-(3-nitrophenyl)-1,3-dihydroimidazo(4,5-b)pyridine-2-one","C414810","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2001,"11174076","Effects of a novel hepatoprotective drug, ZNC-2381, on fas-induced hepatocellular caspase-3 activity and apoptosis in mice.","11174076",136]
["1-(4-bromoacetamidobenzyl)EDTA","1-(4-bromoacetamidobenzyl)EDTA","C042007","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1999,"10208819","Directed cleavage of RNA with protein-tethered EDTA-Fe.","10208819",136]
["1-(4-bromoacetamidobenzyl)EDTA","1-(4-bromoacetamidobenzyl)EDTA","C042007","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2003,"14712693","Principles and methods of affinity cleavage in studying transcription.","14712693",136]
["1-(4-bromophenyl)ethanol","1-(4-bromophenyl)ethanol","C522554","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2008,"17531472","Production of (R)-1-(4-Bromo-phenyl)-ethanol by locally isolated Aspergillus niger using ram horn peptone.","17531472",136]
["1-(4'-carboxyethyl)-6-diphenyl-1,3,5-hexatriene","1-(4'-carboxyethyl)-6-diphenyl-1,3,5-hexatriene","C037385","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2006,"16440197","The alphaPROX assay: fluorescence screening of the inhibitory effects of hydrophilic antioxidants on protein oxidation.","16440197",136]
["1-(4-carboxyphenyl)-3,3-dimethyltriazene","1-(4-carboxyphenyl)-3,3-dimethyltriazene","C030838","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1990,"2402528","Kinetic study employing UV derivative spectroscopy of DM-COOK, antitumor and antimetastatic agent.","2402528",136]
["1-(4-carboxyphenyl)-3,3-dimethyltriazene","1-(4-carboxyphenyl)-3,3-dimethyltriazene","C030838","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1988,"3393581","Stability of the chemical xenogenization inducer, MM-COOK, possible metabolite of the antimetastatic agent, DM-COOK: a kinetic investigation.","3393581",136]
["1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2-cyano-4-hydroxyphenyl)urea","1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2-cyano-4-hydroxyphenyl)urea","C572620","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"21080210","A new diaryl urea compound, D181, induces cell cycle arrest in the G1 and M phases by targeting receptor tyrosine kinases and the microtubule skeleton.","21080210",136]
["1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2-cyano-4-hydroxyphenyl)urea","1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2-cyano-4-hydroxyphenyl)urea","C572620","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"21080210","A new diaryl urea compound, D181, induces cell cycle arrest in the G1 and M phases by targeting receptor tyrosine kinases and the microtubule skeleton.","21080210",136]
["1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2-cyano-4-hydroxyphenyl)urea","1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2-cyano-4-hydroxyphenyl)urea","C572620","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2012,"21080210","A new diaryl urea compound, D181, induces cell cycle arrest in the G1 and M phases by targeting receptor tyrosine kinases and the microtubule skeleton.","21080210",136]
["1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(6-(3-((2-(piperidin-1-yl)ethylamino)methyl)-1H-indazol-1-yl)pyidin-3-yl)urea","1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(6-(3-((2-(piperidin-1-yl)ethylamino)methyl)-1H-indazol-1-yl)pyidin-3-yl)urea","C000608247","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"26076716","1118-20, an indazole diarylurea compound, inhibits hepatocellular carcinoma HepG2 proliferation and tumour angiogenesis involving Wnt/β-catenin pathway and receptor tyrosine kinases.","26076716",136]
["1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(6-(3-((2-(piperidin-1-yl)ethylamino)methyl)-1H-indazol-1-yl)pyidin-3-yl)urea","1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(6-(3-((2-(piperidin-1-yl)ethylamino)methyl)-1H-indazol-1-yl)pyidin-3-yl)urea","C000608247","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"26076716","1118-20, an indazole diarylurea compound, inhibits hepatocellular carcinoma HepG2 proliferation and tumour angiogenesis involving Wnt/β-catenin pathway and receptor tyrosine kinases.","26076716",136]
["1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(6-(3-((2-(piperidin-1-yl)ethylamino)methyl)-1H-indazol-1-yl)pyidin-3-yl)urea","1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(6-(3-((2-(piperidin-1-yl)ethylamino)methyl)-1H-indazol-1-yl)pyidin-3-yl)urea","C000608247","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2015,"26076716","1118-20, an indazole diarylurea compound, inhibits hepatocellular carcinoma HepG2 proliferation and tumour angiogenesis involving Wnt/β-catenin pathway and receptor tyrosine kinases.","26076716",136]
["1-(4-chlorophenyl)-3-(3-((2,4-dichlorophenyl)amino)-1,1-dioxidobenzo(d)isothiazol-5-yl)urea","1-(4-chlorophenyl)-3-(3-((2,4-dichlorophenyl)amino)-1,1-dioxidobenzo(d)isothiazol-5-yl)urea","C000591016","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23063746","Structure-based design and synthesis of novel pseudosaccharine derivatives as antiproliferative agents and kinase inhibitors.","23063746",136]
["1-(4-chlorophenyl)-3-(3-(4-chlorophenyl)-5,5-dimethyl-1-(3-(5-nitrofuran-2-yl)allyldienehydrazinocarbonylmethyl)-2-oxoimidazolidin-4-yl)-1-hydroxyurea","1-(4-chlorophenyl)-3-(3-(4-chlorophenyl)-5,5-dimethyl-1-(3-(5-nitrofuran-2-yl)allyldienehydrazinocarbonylmethyl)-2-oxoimidazolidin-4-yl)-1-hydroxyurea","C492847","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27729187","Eeyarestatin I derivatives with improved aqueous solubility.","27729187",136]
["1-(4-chlorophenyl)-4,4,4-trifluoro-3-hydroxy-2-buten-1-one","1-(4-chlorophenyl)-4,4,4-trifluoro-3-hydroxy-2-buten-1-one","C000622919","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2017,"28771026","Activity of a novel protonophore against methicillin-resistant Staphylococcus aureus.","28771026",136]
["1-(4-chlorophenyl)imidazole","1-(4-chlorophenyl)imidazole","C525744","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,1,2007,"17887776","Structural and thermodynamic consequences of 1-(4-chlorophenyl)imidazole binding to cytochrome P450 2B4.","17887776",136]
["1-(4-Cl-benzyl)-3-Cl-4-(CF3-phenylamino)-1H-pyrrol-2.5-dione","1-(4-Cl-benzyl)-3-Cl-4-(CF3-phenylamino)-1H-pyrrol-2.5-dione","C550019","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23957164","[Mechanisms of nephrotoxicity of novel anticancer compound maleimide derivative MI-1].","23957164",136]
["1-(4-Cl-benzyl)-3-Cl-4-(CF3-phenylamino)-1H-pyrrol-2.5-dione","1-(4-Cl-benzyl)-3-Cl-4-(CF3-phenylamino)-1H-pyrrol-2.5-dione","C550019","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"21469319","[Effect of maleimide derivative on the morpho-functional state of the kidney in experimental colon carcinogenesis in rats].","21469319",136]
["1-(4-dimethylaminomethylphenyl)-8,9-dihydro-7H-2,7,9a-benzo(cd)azulen-6-one","1-(4-dimethylaminomethylphenyl)-8,9-dihydro-7H-2,7,9a-benzo(cd)azulen-6-one","C479234","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24962108","Drug repurposing screen identifies lestaurtinib amplifies the ability of the poly (ADP-ribose) polymerase 1 inhibitor AG14361 to kill breast cancer associated gene-1 mutant and wild type breast cancer cells.","24962108",136]
["1-(4-dimethylaminomethylphenyl)-8,9-dihydro-7H-2,7,9a-benzo(cd)azulen-6-one","1-(4-dimethylaminomethylphenyl)-8,9-dihydro-7H-2,7,9a-benzo(cd)azulen-6-one","C479234","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24962108","Drug repurposing screen identifies lestaurtinib amplifies the ability of the poly (ADP-ribose) polymerase 1 inhibitor AG14361 to kill breast cancer associated gene-1 mutant and wild type breast cancer cells.","24962108",136]
["1-(4-fluorophenyl)-2-oxo-N-(4-((2-(thiophen-3-yl)-3H-imidazo(4,5-b)pyridin-7-yl)oxy)phenyl)-1,2-dihydropyridine-3-carboxamide","1-(4-fluorophenyl)-2-oxo-N-(4-((2-(thiophen-3-yl)-3H-imidazo(4,5-b)pyridin-7-yl)oxy)phenyl)-1,2-dihydropyridine-3-carboxamide","C575180","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22581753","Discovery of 3H-imidazo[4,5-b]pyridines as potent c-Met kinase inhibitors: design, synthesis, and biological evaluation.","22581753",136]
["1-(4-fluorophenyl)-4-(4-(5-fluoro-2-pyrimidinyl)-1-piperazinyl)butan-1-one","1-(4-fluorophenyl)-4-(4-(5-fluoro-2-pyrimidinyl)-1-piperazinyl)butan-1-one","C081146","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1993,"8166884","Microbial reduction of 1-(4-fluorophenyl)-4-[4-(5-fluoro-2-pyrimidinyl)-1- piperazinyl]butan-1-one.","8166884",136]
["1-(4-hydroxy-3-((4-(4-(3-(pyridin-3-yl)acryloyl)phenyl)piperazin-1-yl)methyl)phenyl)-3-(pyridin-3-yl)prop-2-en-1-one","1-(4-hydroxy-3-((4-(4-(3-(pyridin-3-yl)acryloyl)phenyl)piperazin-1-yl)methyl)phenyl)-3-(pyridin-3-yl)prop-2-en-1-one","C559075","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2011,"21377368","New bichalcone analogs as NF-κB inhibitors and as cytotoxic agents inducing Fas/CD95-dependent apoptosis.","21377368",136]
["1-(4-hydroxy-3-methoxyphenyl)-7-(3,4-dihydroxyphenyl)-4E-en-3-heptanone","1-(4-hydroxy-3-methoxyphenyl)-7-(3,4-dihydroxyphenyl)-4E-en-3-heptanone","C539887","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2009,"18836721","Cytotoxic diarylheptanoid induces cell cycle arrest and apoptosis via increasing ATF3 and stabilizing p53 in SH-SY5Y cells.","18836721",136]
["1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium) propane dibromide","1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium) propane dibromide","C481758","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"24853289","A trivalent approach for determining in vitro toxicology: Examination of oxime K027.","24853289",136]
["1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)butane","1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)butane","C488676","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"23811266","Evaluation of the cyto/genotoxicity profile of oxime K048 using human peripheral blood lymphocytes: an introductory study.","23811266",136]
["1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene","1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene","C090768","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1994,"7981835","Determination of pharmaceuticals and related impurities by capillary electrophoresis.","7981835",136]
["1-(4-hydroxyphenyl)-2-n-propyl-1,2-dicarba-closo-dodecaborane","1-(4-hydroxyphenyl)-2-n-propyl-1,2-dicarba-closo-dodecaborane","C000597991","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24695349","Aliphatic substitution of o-carboranyl phenols enhances estrogen receptor beta selectivity.","24695349",136]
["1-(4-iodophenylsulfonyl)-N-(1-oxo-3-phenylpropan-2-yl)pyrrolidine-2-carboxamide","1-(4-iodophenylsulfonyl)-N-(1-oxo-3-phenylpropan-2-yl)pyrrolidine-2-carboxamide","C513860","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2006,"16913717","Synthesis, calpain inhibitory activity, and cytotoxicity of P2-substituted proline and thiaproline peptidyl aldehydes and peptidyl alpha-ketoamides.","16913717",136]
["1-(4-isothiocyanatobenzyl)diethylenetriaminepentaacetic acid","1-(4-isothiocyanatobenzyl)diethylenetriaminepentaacetic acid","C054343","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2000,"10725108","Efficient multigram synthesis of the bifunctional chelating agent (S)-1-p-isothiocyanatobenzyl-diethylenetriaminepentaacetic acid [correction of diethylenetetraminepentaacetic acid].","10725108",136]
["1-(4-methoxyphenyl)pyridinium","1-(4-methoxyphenyl)pyridinium","C026560","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2004,"12971912","Differential effects of carboxyfullerene on MPP+/MPTP-induced neurotoxicity.","12971912",136]
["1-(4-methoxyphenyl)pyridinium","1-(4-methoxyphenyl)pyridinium","C026560","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2007,"17635669","ATP-sensitive potassium channel opener iptakalim protects against MPP-induced astrocytic apoptosis via mitochondria and mitogen-activated protein kinase signal pathways.","17635669",136]
["1-(4-methoxyphenyl)pyridinium","1-(4-methoxyphenyl)pyridinium","C026560","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,1994,"8041505","Apoptosis is induced by 1-methyl-4-phenylpyridinium ion (MPP+) in ventral mesencephalic-striatal co-culture in rat.","8041505",136]
["1-(4-methoxyphenyl)pyridinium","1-(4-methoxyphenyl)pyridinium","C026560","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2013,"23370975","Induction of KLF4 contributes to the neurotoxicity of MPP + in M17 cells: a new implication in Parkinson's disease.","23370975",136]
["1-(4-methylpent-2-enyl)-2-(4-phenylbut-2-enyl)disulfane","1-(4-methylpent-2-enyl)-2-(4-phenylbut-2-enyl)disulfane","C553806","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"20714320","Synthesis, identification and anti-cancer activity of 1-(4-methylpent-2-enyl)-2-(4-phenylbut-2-enyl)disulfane.","20714320",136]
["1-(4-methylpiperazin-1-yl)-3-(5-nitrofuran-2-yl)prop-2-en-1-one","1-(4-methylpiperazin-1-yl)-3-(5-nitrofuran-2-yl)prop-2-en-1-one","C000603673","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"26294215","Small-Molecule NSC59984 Restores p53 Pathway Signaling and Antitumor Effects against Colorectal Cancer via p73 Activation and Degradation of Mutant p53.","26294215",136]
["1-(4-morpholinophenyl)-3-(3-fluorophenyl)propenone","1-(4-morpholinophenyl)-3-(3-fluorophenyl)propenone","C574513","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22339240","Investigation of 1-(4-morpholinophenyl)-3-(4-fluorophenyl)-propenone and 1-(4-morpholinophenyl)-3-(3-fluorophenyl)-propenone as new apoptosis inducers on Spodoptera frugiperda (Sf9) cells.","22339240",136]
["1-(4-morpholinophenyl)-3-(4-fluorophenyl)propenone","1-(4-morpholinophenyl)-3-(4-fluorophenyl)propenone","C574514","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22339240","Investigation of 1-(4-morpholinophenyl)-3-(4-fluorophenyl)-propenone and 1-(4-morpholinophenyl)-3-(3-fluorophenyl)-propenone as new apoptosis inducers on Spodoptera frugiperda (Sf9) cells.","22339240",136]
["1-(4-nitrophenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone","1-(4-nitrophenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone","C512077","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2006,"16759106","Imino-tetrahydro-benzothiazole derivatives as p53 inhibitors: discovery of a highly potent in vivo inhibitor and its action mechanism.","16759106",136]
["1-(4-nitrophenyl)-2,5-di(2-thienyl)-1 H-pyrrole","1-(4-nitrophenyl)-2,5-di(2-thienyl)-1 H-pyrrole","C545172","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2009,"19520619","Electrochemical polymerization of 1-(4-nitrophenyl)-2,5-di(2-thienyl)-1 H-pyrrole as a novel immobilization platform for microbial sensing.","19520619",136]
["1-(4-nitrophenyl)piperazine","1-(4-nitrophenyl)piperazine","C000595696","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"24858345","Investigation on the inclusion interaction of 4-sulfonatocalix[n]arenes with 1-(4-nitrophenyl)piperazine.","24858345",136]
["1-(4-nitrophenylsulfonyl)-N-(1-oxo-3-phenylpropan-2-yl)pyrrolidine-2-carboxamide","1-(4-nitrophenylsulfonyl)-N-(1-oxo-3-phenylpropan-2-yl)pyrrolidine-2-carboxamide","C513859","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2006,"16913717","Synthesis, calpain inhibitory activity, and cytotoxicity of P2-substituted proline and thiaproline peptidyl aldehydes and peptidyl alpha-ketoamides.","16913717",136]
["1-(4-toluenesulfonyl)cytosine","1-(4-toluenesulfonyl)cytosine","C509984","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2008,"17898928","Atypical cytostatic mechanism of N-1-sulfonylcytosine derivatives determined by in vitro screening and computational analysis.","17898928",136]
["1-(4-toluenesulfonyl)cytosine","1-(4-toluenesulfonyl)cytosine","C509984","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2008,"17898928","Atypical cytostatic mechanism of N-1-sulfonylcytosine derivatives determined by in vitro screening and computational analysis.","17898928",136]
["1-(4-trifluoromethoxyphenyl)-3-(4-(5-trifluoromethyl-2,5-dihydropyrazol-1-yl)phenyl)urea","1-(4-trifluoromethoxyphenyl)-3-(4-(5-trifluoromethyl-2,5-dihydropyrazol-1-yl)phenyl)urea","C577854","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22354145","AW00179 potentiates TRAIL-mediated death of human lung cancer H1299 cells through ROS-JNK-c-Jun-mediated up-regulation of DR5 and down-regulation of anti-apoptotic molecules.","22354145",136]
["1-(5-((2,4-difluorophenyl)thio)-4-nitrothiophen-2-yl)ethanone","1-(5-((2,4-difluorophenyl)thio)-4-nitrothiophen-2-yl)ethanone","C570895","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"24136231","USP7 inhibitor P22077 inhibits neuroblastoma growth via inducing p53-mediated apoptosis.","24136231",136]
["1-(5-((2,4-difluorophenyl)thio)-4-nitrothiophen-2-yl)ethanone","1-(5-((2,4-difluorophenyl)thio)-4-nitrothiophen-2-yl)ethanone","C570895","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"24136231","USP7 inhibitor P22077 inhibits neuroblastoma growth via inducing p53-mediated apoptosis.","24136231",136]
["1-(5-((2,4-difluorophenyl)thio)-4-nitrothiophen-2-yl)ethanone","1-(5-((2,4-difluorophenyl)thio)-4-nitrothiophen-2-yl)ethanone","C570895","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28967922","Inhibition of USP10 induces degradation of oncogenic FLT3.","28967922",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C1155,B1155)","v":"1-(5-(2-(3,5-dimethoxyphenyl)vinyl)-2-methoxyphenyl)-3-(2-morpholin-4-ylethyl)urea"},"1-(5-(2-(3,5-dimethoxyphenyl)vinyl)-2-methoxyphenyl)-3-(2-morpholin-4-ylethyl)urea","C539258","3_KE",870,3,"Cell Proliferation","Increase",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J1155,K1155)","v":"Cell Proliferation"},"D049109","Cell Proliferation",1,2,2009,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q1155,Q1155)","v":"18516499"},"Development of water soluble derivatives of cis-3, 4', 5-trimethoxy-3'-aminostilbene for optimization and use in cancer therapy.","18516499",136]
["1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine","1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine","C552956","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Atrophy","D001284","Atrophy",1,1,2016,"27316584","Comparison of vonoprazan and proton pump inhibitors for eradication of Helicobacter pylori.","27316584",136]
["1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine","1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine","C552956","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2010,"20624992","1-[5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine monofumarate (TAK-438), a novel and potent potassium-competitive acid blocker for the treatment of acid-related diseases.","20624992",136]
["1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine","1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine","C552956","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2011,"21411494","A study comparing the antisecretory effect of TAK-438, a novel potassium-competitive acid blocker, with lansoprazole in animals.","21411494",136]
["1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine","1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine","C552956","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2015,"26193978","Acid-inhibitory effects of vonoprazan 20 mg compared with esomeprazole 20 mg or rabeprazole 10 mg in healthy adult male subjects--a randomised open-label cross-over study.","26193978",136]
["1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine","1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine","C552956","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2016,"26991399","Potent acid inhibition by vonoprazan in comparison with esomeprazole, with reference to CYP2C19 genotype.","26991399",136]
["1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine","1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine","C552956","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2016,"27287852","Characteristics of the Novel Potassium-Competitive Acid Blocker Vonoprazan Fumarate (TAK-438).","27287852",136]
["1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine","1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine","C552956","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2017,"28662503","The Effects of Switching to Vonoprazan, a Novel Potassium-Competitive Acid Blocker, on Gastric Acidity and Reflux Patterns in Patients with Erosive Esophagitis Refractory to Proton Pump Inhibitors.","28662503",136]
["1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine","1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine","C552956","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2018,"29337157","Update on use of vonoprazan: a competitive acid blocker (P-CAB).","29337157",136]
["1-(5-(3-((1-(4-fluorobenzyl)-1H-1,2,3-triazol-4-yl)methoxy)-4-methoxyphenyl)-3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)ethanone","1-(5-(3-((1-(4-fluorobenzyl)-1H-1,2,3-triazol-4-yl)methoxy)-4-methoxyphenyl)-3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)ethanone","C000615606","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"26854643","Synthesis and Biological Evaluation of 1,2,3-triazole tethered Pyrazoline and Chalcone Derivatives.","26854643",136]
["1-(5-(3-((1-(4-fluorobenzyl)-1H-1,2,3-triazol-4-yl)methoxy)-4-methoxyphenyl)-3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)ethanone","1-(5-(3-((1-(4-fluorobenzyl)-1H-1,2,3-triazol-4-yl)methoxy)-4-methoxyphenyl)-3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)ethanone","C000615606","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"26854643","Synthesis and Biological Evaluation of 1,2,3-triazole tethered Pyrazoline and Chalcone Derivatives.","26854643",136]
["1-(5-(4-bromophenoxy)pentyl)-3-(4-pyridyl)-2-imidazolidinone","1-(5-(4-bromophenoxy)pentyl)-3-(4-pyridyl)-2-imidazolidinone","C492441","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,1,2004,"15328120","Mutation in enterovirus 71 capsid protein VP1 confers resistance to the inhibitory effects of pyridyl imidazolidinone.","15328120",136]
["1-(5,5,5-trichloro-2-methoxy-4-oxopenten-2-yl)-4-trichloromethylpyrimidin-2(1H)-one","1-(5,5,5-trichloro-2-methoxy-4-oxopenten-2-yl)-4-trichloromethylpyrimidin-2(1H)-one","C000597458","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24848672","Antitumoral activity of a trichloromethyl pyrimidine analogue: molecular cross-talk between intrinsic and extrinsic apoptosis.","24848672",136]
["1-(5,5,5-trichloro-2-methoxy-4-oxopenten-2-yl)-4-trichloromethylpyrimidin-2(1H)-one","1-(5,5,5-trichloro-2-methoxy-4-oxopenten-2-yl)-4-trichloromethylpyrimidin-2(1H)-one","C000597458","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24848672","Antitumoral activity of a trichloromethyl pyrimidine analogue: molecular cross-talk between intrinsic and extrinsic apoptosis.","24848672",136]
["1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl (E)-2-(4-(3-oxo-3-(3-(trifluoromethoxy)phenyl)prop-1-en-1-yl)phenoxy)acetate","1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl (E)-2-(4-(3-oxo-3-(3-(trifluoromethoxy)phenyl)prop-1-en-1-yl)phenoxy)acetate","C000620830","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28099785","A Dual Topoisomerase Inhibitor of Intense Pro-Apoptotic and Antileukemic Nature for Cancer Treatment.","28099785",136]
["1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl (E)-2-(4-(3-oxo-3-(3-(trifluoromethoxy)phenyl)prop-1-en-1-yl)phenoxy)acetate","1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl (E)-2-(4-(3-oxo-3-(3-(trifluoromethoxy)phenyl)prop-1-en-1-yl)phenoxy)acetate","C000620830","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28211616","Design, Synthesis, and Biological Evaluation of Chalcone-Containing Shikonin Derivatives as Inhibitors of Tubulin Polymerization.","28211616",136]
["1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl (E)-2-(4-(3-oxo-3-(3-(trifluoromethoxy)phenyl)prop-1-en-1-yl)phenoxy)acetate","1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl (E)-2-(4-(3-oxo-3-(3-(trifluoromethoxy)phenyl)prop-1-en-1-yl)phenoxy)acetate","C000620830","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28211616","Design, Synthesis, and Biological Evaluation of Chalcone-Containing Shikonin Derivatives as Inhibitors of Tubulin Polymerization.","28211616",136]
["1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-enyl-3-(3-(trifluoromethyl)phenyl)acrylate","1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-enyl-3-(3-(trifluoromethyl)phenyl)acrylate","C586338","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2013,"23066914","Design, synthesis and biological evaluation of cinnamic acyl shikonin derivatives.","23066914",136]
["1-(5-bromo-2-pyridylazo)-2-naphthol-6-sulfonic acid","1-(5-bromo-2-pyridylazo)-2-naphthol-6-sulfonic acid","C433167","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2001,"11324621","Multiwavelength spectral correction for the simultaneous determination of Cu(II), Fe(II), and Zn(II) with 1-(5-bromo-2-pyridylazo)-2-naphthol-6-sulfonic acid.","11324621",136]
["1-(5-carboxypentyl)-4-(2-(N-ethyl-carbazole-3-yl)vinyl)pyridinium bromide","1-(5-carboxypentyl)-4-(2-(N-ethyl-carbazole-3-yl)vinyl)pyridinium bromide","C000613210","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2016,"26249113","Spectra, stability and labeling of 1-(5-carboxypentyl)-4-(2-(N-ethyl-carbazole-3-yl) vinyl) pyridinium bromide with a large Stokes shift.","26249113",136]
["1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea","1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea","C508388","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,1,2013,"23576748","Stoichiometry for drug potentiation of a pentameric ion channel.","23576748",136]
["1-(5-chloro-2-methyl-phenyl)-3-(4-(5-trifluoromethyl-pyrazol-1-yl)-phenyl)thiourea","1-(5-chloro-2-methyl-phenyl)-3-(4-(5-trifluoromethyl-pyrazol-1-yl)-phenyl)thiourea","C575050","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22622069","Thiourea compound AW00178 sensitizes human H1299 lung carcinoma cells to TRAIL-mediated apoptosis.","22622069",136]
["1-(5-chloro-6-(3-methyl-4-(6-(trifluoromethyl)-4-(3,4,5-trifluorophenyl)-1H-benzo(d)imidazol-2-yl)piperazin-1-yl)pyridin-3-yl)ethane-1,2-diol","1-(5-chloro-6-(3-methyl-4-(6-(trifluoromethyl)-4-(3,4,5-trifluorophenyl)-1H-benzo(d)imidazol-2-yl)piperazin-1-yl)pyridin-3-yl)ethane-1,2-diol","C512086","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2006,"16759115","Design of potent, orally available antagonists of the transient receptor potential vanilloid 1. Structure-activity relationships of 2-piperazin-1-yl-1H-benzimidazoles.","16759115",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","3_KE",870,3,"Cell Proliferation","Increase","Airway Remodeling","D056151","Airway Remodeling",2,3,2010,"19858775","Effects of rho-kinase inhibition on pulmonary hypertension, lung growth, and structure in neonatal rats chronically exposed to hypoxia.","19858775",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2001,"11137708","Cell cycle phase specificity in the potentiation of etoposide-induced DNA damage and apoptosis by KN-62, an inhibitor of calcium-calmodulin-dependent enzymes.","11137708",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2000,"11146107","Staurosporine- and H-7-induced cell death in SH-SY5Y neuroblastoma cells is associated with caspase-2 and caspase-3 activation, but not with activation of the FAS/FAS-L-caspase-8 signaling pathway.","11146107",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2001,"11521953","H-7 and fetal calf serum (FCS) act synergistically to increase apoptosis in the KB line of human oral carcinoma cells.","11521953",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2002,"12176662","Mechanisms of mitogenic and anti-apoptotic signaling by glucose-dependent insulinotropic polypeptide in beta(INS-1)-cells.","12176662",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2003,"12602923","Concurrent exposure to heat shock and H7 synergizes to trigger breast cancer cell apoptosis while sparing normal cells.","12602923",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2004,"12933355","Rho kinase inhibition initiates apoptosis in human airway epithelial cells.","12933355",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2004,"14592842","Long-term inhibition of Rho-kinase suppresses neointimal formation after stent implantation in porcine coronary arteries: involvement of multiple mechanisms.","14592842",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2003,"14654170","Pretreatment with PKC inhibitor triggers TNF-alpha induced apoptosis in TNF-alpha-resistant B16 melanoma BL6 cells.","14654170",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2003,"14666661","c-IAP1 is overexpressed in HL-60 cells selected for doxorubicin resistance: effects on etoposide-induced apoptosis.","14666661",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2004,"14766004","Evidence that protein kinase Cdelta is not required for palmitate-induced cytotoxicity in BRIN-BD11 beta-cells.","14766004",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2004,"15155383","Enhanced P2X7 activity in human fibroblasts from diabetic patients: a possible pathogenetic mechanism for vascular damage in diabetes.","15155383",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2004,"15469081","[The influence of protein kinase C inhibitor in eosinophil apoptosis of nasal polyps].","15469081",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2005,"15851596","Fasudil, a Rho-kinase inhibitor, attenuates angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-deficient mice by inhibiting apoptosis and proteolysis.","15851596",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2005,"15998434","Fasudil hydrochloride hydrate, a Rho-kinase (ROCK) inhibitor, suppresses collagen production and enhances collagenase activity in hepatic stellate cells.","15998434",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2005,"16228288","N-Arylpiperazine modified analogues of the P2X7 receptor KN-62 antagonist are potent inducers of apoptosis of human primary osteoclasts.","16228288",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2006,"16641138","Protective effect of fasudil, a Rho-kinase inhibitor, on chemokine expression, leukocyte recruitment, and hepatocellular apoptosis in septic liver injury.","16641138",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2007,"17127075","Long-term inhibition of Rho kinase with fasudil attenuates high flow induced pulmonary artery remodeling in rats.","17127075",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2007,"17513600","Fasudil inhibits vascular endothelial growth factor-induced angiogenesis in vitro and in vivo.","17513600",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2007,"17761835","Rho-kinase inhibitor prevents hepatocyte damage in acute liver injury induced by carbon tetrachloride in rats.","17761835",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2009,"18757509","Efficacy of Rho-kinase inhibition in promoting cell survival and reducing reactive gliosis in the rodent retina.","18757509",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2009,"18840783","Rho kinase inhibition by fasudil ameliorates diabetes-induced microvascular damage.","18840783",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"20949056","Inhibition of Plasmodium falciparum field isolates-mediated endothelial cell apoptosis by Fasudil: therapeutic implications for severe malaria.","20949056",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"20233282","Chronic treatment with an oral rho-kinase inhibitor restores erectile function by suppressing corporal apoptosis in diabetic rats.","20233282",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"20364104","Rho-kinase inhibitor, fasudil, suppresses glioblastoma cell line progression in vitro and in vivo.","20364104",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2010,"20882700","Fasudil protects hippocampal neurons against hypoxia-reoxygenation injury by suppressing microglial inflammatory responses in mice.","20882700",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"21061151","Fasudil mesylate protects PC12 cells from oxidative stress injury via the Bax-mediated pathway.","21061151",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"21797820","Fasudil ameliorates rhabdomyolysis-induced acute kidney injury via inhibition of apoptosis.","21797820",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"21917869","Fasudil inhibits the proliferation and contractility and induces cell cycle arrest and apoptosis of human endometriotic stromal cells: a promising agent for the treatment of endometriosis.","21917869",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2011,"21929346","Rho kinase as a therapeutic target in cardiovascular disease.","21929346",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22160250","Fasudil, a Rho-kinase inhibitor, protects against excessive endurance exercise training-induced cardiac hypertrophy, apoptosis and fibrosis in rats.","22160250",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22425182","The Rho-kinase inhibitor inhibits proliferation and metastasis of small cell lung cancer.","22425182",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22429817","Long-term administration of fasudil improves cardiomyopathy in streptozotocin-induced diabetic rats.","22429817",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22481618","The Rho kinase inhibitor fasudil is involved in p53-mediated apoptosis in human hepatocellular carcinoma cells.","22481618",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22552888","Rho-kinase inhibitor, fasudil, prevents neuronal apoptosis via the Akt activation and PTEN inactivation in the ischemic penumbra of rat brain.","22552888",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"23118936","Fasudil protects the heart against ischemia-reperfusion injury by attenuating endoplasmic reticulum stress and modulating SERCA activity: the differential role for PI3K/Akt and JAK2/STAT3 signaling pathways.","23118936",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23558879","Protective effects of fasudil hydrochloride post-conditioning on acute myocardial ischemia/reperfusion injury in rats.","23558879",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24406296","Rho kinase inhibition by fasudil suppresses lipopolysaccharide-induced apoptosis of rat pulmonary microvascular endothelial cells via JNK and p38 MAPK pathway.","24406296",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24908363","The Rho-kinase inhibitor HA-1077 suppresses proliferation/migration and induces apoptosis of urothelial cancer cells.","24908363",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2014,"25231456","Inhibition of Rho-kinase by fasudil restores the cardioprotection of ischemic postconditioninng in hypercholesterolemic rat heart.","25231456",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"25272944","Cardioprotective effects of low-dose combination therapy with rosuvastatin and fasudil in the isolated rat heart.","25272944",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C1219,B1219)","v":"1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine"},"1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","5_KE",768,5,"Cytotoxicity","Increase",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J1219,K1219)","v":"Apoptosis"},"D017209","Apoptosis",1,2,2015,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q1219,Q1219)","v":"25697583"},"Fasudil prevents calcium oxalate crystal deposit and renal fibrogenesis in glyoxylate-induced nephrolithic mice.","25697583",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25931586","RNAi profiling of primary human AML cells identifies ROCK1 as a therapeutic target and nominates fasudil as an antileukemic drug.","25931586",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2016,"26635024","Fasudil, a Rho-Associated Protein Kinase Inhibitor, Attenuates Traumatic Retinal Nerve Injury in Rabbits.","26635024",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"26725099","Combination treatment with fasudil and clioquinol produces synergistic anti-tumor effects in U87 glioblastoma cells by activating apoptosis and autophagy.","26725099",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2016,"26838736","ROCK inhibition with fasudil promotes early functional recovery of spinal cord injury in rats by enhancing microglia phagocytosis.","26838736",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27333569","Rho-Kinase inhibitor fasudil suppresses high glucose-induced H9c2 cell apoptosis through activation of autophagy.","27333569",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28712398","[Fasudil attenuates mitochondrial injury and apoptosis in rat model of myocardial ischemia/reperfusion injury].","28712398",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28820432","Rho-Kinase Blockade Attenuates Podocyte Apoptosis by Inhibiting the Notch Signaling Pathway in Diabetic Nephropathy.","28820432",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2016,"28963834","[Effects of the Rho-kinase inhibitor fasudil on the invasion, migration, and apoptosis of human prostate cancer PC3 and DU145 cells].","28963834",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,1996,"8632693","Protective action of isoquinolinesulfonamides in in vitro models of neuronal apoptosis.","8632693",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,1997,"9020141","1-(5-Isoquinolinesulfonyl)-2-methylpiperazine induces apoptosis in human neuroblastoma cells, SH-SY5Y, through a p53-dependent pathway.","9020141",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,1997,"9247701","Preincubation of thymocytes with 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride (H-7) induces apoptosis in non-stimulated thymocytes.","9247701",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,1998,"9498817","Inhibition of HIV-1 Nef-induced apoptosis of uninfected human blood cells by serine/threonine protein kinase inhibitors, fasudil hydrochloride and M3.","9498817",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,1998,"9700717","H-7-induced apoptosis in the cells of a Drosophila neuronal cell line through affecting unidentified H-7-sensitive substance(s).","9700717",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,1998,"9840801","H-7 stimulates desmosome formation and inhibits growth in KB oral carcinoma cells.","9840801",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2004,"15236242","Fibroblast growth and H-7 protein kinase inhibitor response monitored in microimpedance sensor arrays.","15236242",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2005,"15998434","Fasudil hydrochloride hydrate, a Rho-kinase (ROCK) inhibitor, suppresses collagen production and enhances collagenase activity in hepatic stellate cells.","15998434",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2007,"17513600","Fasudil inhibits vascular endothelial growth factor-induced angiogenesis in vitro and in vivo.","17513600",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2007,"16963120","KN-62 analogues as potent differentiating agents of HL-60 cells.","16963120",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2006,"17125608","[Fasudil inhibits HSC adhesion, migration and proliferation via Rho/ROCK pathway].","17125608",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2007,"17127075","Long-term inhibition of Rho kinase with fasudil attenuates high flow induced pulmonary artery remodeling in rats.","17127075",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2007,"17254483","Inhibition of rho kinase attenuates high flow induced pulmonary hypertension in rats.","17254483",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2007,"17460274","The Rho-kinase inhibitor H-1152P suppresses the wound-healing activities of human Tenon's capsule fibroblasts in vitro.","17460274",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2007,"17554385","The rho-kinase inhibitors Y-27632 and fasudil act synergistically with imatinib to inhibit the expansion of ex vivo CD34(+) CML progenitor cells.","17554385",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2008,"18369695","Antiangiogenic properties of fasudil, a potent Rho-Kinase inhibitor.","18369695",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"19052484","Fasudil hydrochloride hydrate, a Rho-kinase inhibitor, suppresses 5-hydroxytryptamine-induced pulmonary artery smooth muscle cell proliferation via JNK and ERK1/2 pathway.","19052484",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20077431","Therapeutic potential of experimental autoimmune encephalomyelitis by Fasudil, a Rho kinase inhibitor.","20077431",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"20300976","Rho kinase inhibitor fasudil suppresses migration and invasion though down-regulating the expression of VEGF in lung cancer cell line A549.","20300976",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20364104","Rho-kinase inhibitor, fasudil, suppresses glioblastoma cell line progression in vitro and in vivo.","20364104",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20921973","Effect of fasudil on growth, adhesion, invasion, and migration of 95D lung carcinoma cells in vitro.","20921973",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21457293","Fasudil hydrochloride hydrate, a Rho-kinase inhibitor, suppresses high glucose-induced proliferation and collagen synthesis in rat cardiac fibroblasts.","21457293",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21501850","Preventive and therapeutic effects of the selective Rho-kinase inhibitor fasudil on experimental autoimmune neuritis.","21501850",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2011,"21567077","The Rho kinase inhibitor fasudil augments the number of functional endothelial progenitor cells in ex vivo cultures.","21567077",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21917869","Fasudil inhibits the proliferation and contractility and induces cell cycle arrest and apoptosis of human endometriotic stromal cells: a promising agent for the treatment of endometriosis.","21917869",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"22040563","Fasudil inhibits platelet-derived growth factor-induced human pulmonary artery smooth muscle cell proliferation by up-regulation of p27kip¹ via the ERK signal pathway.","22040563",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22138731","Cytoskeletal drugs prevent posterior capsular opacification in human lens capsule in vitro.","22138731",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22425182","The Rho-kinase inhibitor inhibits proliferation and metastasis of small cell lung cancer.","22425182",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22481618","The Rho kinase inhibitor fasudil is involved in p53-mediated apoptosis in human hepatocellular carcinoma cells.","22481618",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"23099322","Fasudil suppresses fibrosarcoma growth by stimulating secretion of the chemokine CXCL14/BRAK.","23099322",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2014,"24579970","Influence of Rho kinase inhibitor Fasudil on late endothelial progenitor cells in peripheral blood of COPD patients with pulmonary artery hypertension.","24579970",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"25333508","Fasudil inhibits prostate cancer-induced angiogenesis in vitro.","25333508",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24908363","The Rho-kinase inhibitor HA-1077 suppresses proliferation/migration and induces apoptosis of urothelial cancer cells.","24908363",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"25263338","Fasudil regulates T cell responses through polarization of BV-2 cells in mice experimental autoimmune encephalomyelitis.","25263338",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25697583","Fasudil prevents calcium oxalate crystal deposit and renal fibrogenesis in glyoxylate-induced nephrolithic mice.","25697583",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25934709","Rho Kinase Inhibitor Fasudil Suppresses the Vasculogenic Mimicry of B16 Mouse Melanoma Cells Both In Vitro and In Vivo.","25934709",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"26458725","Fasudil, a Rho‑kinase inhibitor, prevents intima‑media thickening in a partially ligated carotid artery mouse model: Effects of fasudil in flow‑induced vascular remodeling.","26458725",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"26522357","[Promoting effect of Fasudil on the proliferation and survival of bone marrow-derived neural stem cells in vitro].","26522357",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"26725099","Combination treatment with fasudil and clioquinol produces synergistic anti-tumor effects in U87 glioblastoma cells by activating apoptosis and autophagy.","26725099",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27333569","Rho-Kinase inhibitor fasudil suppresses high glucose-induced H9c2 cell apoptosis through activation of autophagy.","27333569",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2016,"27441000","Fasudil inhibits LPS-induced migration of retinal microglial cells via regulating p38-MAPK signaling pathway.","27441000",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2016,"27951595","Corneal Endothelial Cell Migration and Proliferation Enhanced by Rho Kinase (ROCK) Inhibitors in In Vitro and In Vivo Models.","27951595",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28225457","RhoA/ROCK pathway inhibition by fasudil suppresses the vasculogenic mimicry of U2OS osteosarcoma cells in vitro.","28225457",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2016,"28963834","[Effects of the Rho-kinase inhibitor fasudil on the invasion, migration, and apoptosis of human prostate cancer PC3 and DU145 cells].","28963834",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2017,"28470298","Fluorescence enhancement and pKa shift of a rho kinase inhibitor by a synthetic receptor.","28470298",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1995,"7624870","A protein kinase C inhibitor attenuates cyanide toxicity in vivo.","7624870",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2000,"10672851","The protein kinase inhibitor fasudil protects against ischemic myocardial injury induced by endothelin-1 in the rabbit.","10672851",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2000,"11073837","Rho-kinase is involved in macrophage-mediated formation of coronary vascular lesions in pigs in vivo.","11073837",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2007,"17513600","Fasudil inhibits vascular endothelial growth factor-induced angiogenesis in vitro and in vivo.","17513600",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2008,"18566226","Fasudil-induced hypoxia-inducible factor-1alpha degradation disrupts a hypoxia-driven vascular endothelial growth factor autocrine mechanism in endothelial cells.","18566226",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2011,"21166955","HA1077, a Rho kinase inhibitor, suppresses glioma-induced angiogenesis by targeting the Rho-ROCK and the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (MEK/ERK) signal pathways.","21166955",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2011,"21378147","Rho-kinase inhibition ameliorates peritoneal fibrosis and angiogenesis in a rat model of peritoneal sclerosis.","21378147",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,2,2013,"23859538","Inhibition of Rho-kinase alleviates peritoneal fibrosis and angiogenesis in a rat model of peritoneal dialysis.","23859538",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2014,"25333508","Fasudil inhibits prostate cancer-induced angiogenesis in vitro.","25333508",136]
["1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2015,"25934709","Rho Kinase Inhibitor Fasudil Suppresses the Vasculogenic Mimicry of B16 Mouse Melanoma Cells Both In Vitro and In Vivo.","25934709",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C1283,B1283)","v":"1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine"},"1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","D019307","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J1283,K1283)","v":"Neovascularization, Pathologic"},"D009389","Neovascularization, Pathologic",1,1,2017,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q1283,Q1283)","v":"28225457"},"RhoA/ROCK pathway inhibition by fasudil suppresses the vasculogenic mimicry of U2OS osteosarcoma cells in vitro.","28225457",136]
["1-(5-isoquinolinylsulfonyl)-3-methylpiperazine","1-(5-isoquinolinylsulfonyl)-3-methylpiperazine","C080501","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2004,"15469081","[The influence of protein kinase C inhibitor in eosinophil apoptosis of nasal polyps].","15469081",136]
["1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione","1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione","C060229","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2005,"15698999","[Inhibition of phospholipase C gamma1 signaling pathway promotes apoptosis of human colorectal carcinoma cells].","15698999",136]
["1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione","1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione","C060229","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2006,"16546723","[Sensitization of human glioma SWO cell line to tumor necrosis factor-induced apoptosis by blocking phospholipase C-gamma1 signaling pathway].","16546723",136]
["1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione","1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione","C060229","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2007,"17927852","[Effects of blocking phospholipase C-gamma1 signaling pathway on proliferation and apoptosis of human colorectal cancer cell line LoVo].","17927852",136]
["1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione","1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione","C060229","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2006,"16546723","[Sensitization of human glioma SWO cell line to tumor necrosis factor-induced apoptosis by blocking phospholipase C-gamma1 signaling pathway].","16546723",136]
["1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione","1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione","C060229","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2007,"17927852","[Effects of blocking phospholipase C-gamma1 signaling pathway on proliferation and apoptosis of human colorectal cancer cell line LoVo].","17927852",136]
["1-(6-(3,5-dichloro-4-hydroxyphenyl)-4-((4-((dimethylamino)methyl)cyclohexyl)amino)-1,5-naphthyridin-3-yl)ethanone","1-(6-(3,5-dichloro-4-hydroxyphenyl)-4-((4-((dimethylamino)methyl)cyclohexyl)amino)-1,5-naphthyridin-3-yl)ethanone","C585656","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23673321","MELK inhibitor, novel molecular targeted therapeutics for human cancer stem cells.","23673321",136]
["1-(6-(3,5-dichloro-4-hydroxyphenyl)-4-((4-((dimethylamino)methyl)cyclohexyl)amino)-1,5-naphthyridin-3-yl)ethanone","1-(6-(3,5-dichloro-4-hydroxyphenyl)-4-((4-((dimethylamino)methyl)cyclohexyl)amino)-1,5-naphthyridin-3-yl)ethanone","C585656","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2017,"28235006","Genome-wide effects of MELK-inhibitor in triple-negative breast cancer cells indicate context-dependent response with p53 as a key determinant.","28235006",136]
["1-(6-(3,5-dichloro-4-hydroxyphenyl)-4-((4-((dimethylamino)methyl)cyclohexyl)amino)-1,5-naphthyridin-3-yl)ethanone","1-(6-(3,5-dichloro-4-hydroxyphenyl)-4-((4-((dimethylamino)methyl)cyclohexyl)amino)-1,5-naphthyridin-3-yl)ethanone","C585656","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"23283305","Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancer.","23283305",136]
["1-(6-(3,5-dichloro-4-hydroxyphenyl)-4-((4-((dimethylamino)methyl)cyclohexyl)amino)-1,5-naphthyridin-3-yl)ethanone","1-(6-(3,5-dichloro-4-hydroxyphenyl)-4-((4-((dimethylamino)methyl)cyclohexyl)amino)-1,5-naphthyridin-3-yl)ethanone","C585656","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"26918358","Preclinical evaluation of biomarkers associated with antitumor activity of MELK inhibitor.","26918358",136]
["1-(6-(3,5-dichloro-4-hydroxyphenyl)-4-((4-((dimethylamino)methyl)cyclohexyl)amino)-1,5-naphthyridin-3-yl)ethanone","1-(6-(3,5-dichloro-4-hydroxyphenyl)-4-((4-((dimethylamino)methyl)cyclohexyl)amino)-1,5-naphthyridin-3-yl)ethanone","C585656","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2017,"28235006","Genome-wide effects of MELK-inhibitor in triple-negative breast cancer cells indicate context-dependent response with p53 as a key determinant.","28235006",136]
["1-(9'-(o-carboxyphenyl)-6'-amino-2'-chloro-3'-xanthanone)-4,10-(diethyl)-7-(2-pyridylmethyl)-1,4,7,10-tetraazacyclododecane","1-(9'-(o-carboxyphenyl)-6'-amino-2'-chloro-3'-xanthanone)-4,10-(diethyl)-7-(2-pyridylmethyl)-1,4,7,10-tetraazacyclododecane","C473809","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2002,"12470079","The rhodafluor family. An initial study of potential ratiometric fluorescent sensors for Zn2+.","12470079",136]
["1-(9-fluorenyl)ethyl chloroformate","1-(9-fluorenyl)ethyl chloroformate","C052812","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2017,"28756893","(+) or (-)-1-(9-fluorenyl)ethyl chloroformate as chiral derivatizing agent: A review.","28756893",136]
["1-(9-fluorenyl)methyl chloroformate","1-(9-fluorenyl)methyl chloroformate","C054007","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2001,"11758751","Chiral separation of 9-fluorenylmethyl chloroformate- and dansyl chloride-derivatized D,L-serine by gamma-cyclodextrin-bonded high-performance liquid chromatography.","11758751",136]
["1-(9-fluorenyl)methyl chloroformate","1-(9-fluorenyl)methyl chloroformate","C054007","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2006,"17022015","Online acid barrage stacking anti-salt injection for capillary electrophoresis of 9-fluorenylmethylchloroformate-derivatized amino acids in high ionic strength solutions by UV detection.","17022015",136]
["1-(9-fluorenyl)methyl chloroformate","1-(9-fluorenyl)methyl chloroformate","C054007","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"17868178","Determination of sulphonamides in animal tissues by high performance liquid chromatography with pre-column derivatization of 9-fluorenylmethyl chloroformate.","17868178",136]
["1-(9-fluorenyl)methyl chloroformate","1-(9-fluorenyl)methyl chloroformate","C054007","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2009,"19215925","Amino acid analysis by high-performance liquid chromatography after derivatization with 9-fluorenylmethyloxycarbonyl chloride Literature overview and further study.","19215925",136]
["1-(9-hydroperoxy-10,12-octadecadienoyl)glycerol","1-(9-hydroperoxy-10,12-octadecadienoyl)glycerol","C426010","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2001,"11295443","Enzyme-catalyzed and enzyme-triggered pathways in dioxygenation of 1-monolinoleoyl-rac-glycerol by potato tuber lipoxygenase.","11295443",136]
["1-(acetyloxy)-3,5,6,6a,7,8,9,10-octahydro-10-hydroxy-7,8-dimethyl-7-(3-methylpenta-2,4-dien-1-yl)naphtho(1,8a-c)furan-3,5-diyl dibutanoate","1-(acetyloxy)-3,5,6,6a,7,8,9,10-octahydro-10-hydroxy-7,8-dimethyl-7-(3-methylpenta-2,4-dien-1-yl)naphtho(1,8a-c)furan-3,5-diyl dibutanoate","C548433","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"20816779","Casearin X exhibits cytotoxic effects in leukemia cells triggered by apoptosis.","20816779",136]
["1-(acetyloxy)-3,5,6,6a,7,8,9,10-octahydro-10-hydroxy-7,8-dimethyl-7-(3-methylpenta-2,4-dien-1-yl)naphtho(1,8a-c)furan-3,5-diyl dibutanoate","1-(acetyloxy)-3,5,6,6a,7,8,9,10-octahydro-10-hydroxy-7,8-dimethyl-7-(3-methylpenta-2,4-dien-1-yl)naphtho(1,8a-c)furan-3,5-diyl dibutanoate","C548433","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"25452174","Morphological and biochemical alterations activated by antitumor clerodane diterpenes.","25452174",136]
["1-(acetyloxy)-3,5,6,6a,7,8,9,10-octahydro-10-hydroxy-7,8-dimethyl-7-(3-methylpenta-2,4-dien-1-yl)naphtho(1,8a-c)furan-3,5-diyl dibutanoate","1-(acetyloxy)-3,5,6,6a,7,8,9,10-octahydro-10-hydroxy-7,8-dimethyl-7-(3-methylpenta-2,4-dien-1-yl)naphtho(1,8a-c)furan-3,5-diyl dibutanoate","C548433","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"25452174","Morphological and biochemical alterations activated by antitumor clerodane diterpenes.","25452174",136]
["1-(acetyloxy)-3,5,6,6a,7,8,9,10-octahydro-10-hydroxy-7,8-dimethyl-7-(3-methylpenta-2,4-dien-1-yl)naphtho(1,8a-c)furan-3,5-diyl dibutanoate","1-(acetyloxy)-3,5,6,6a,7,8,9,10-octahydro-10-hydroxy-7,8-dimethyl-7-(3-methylpenta-2,4-dien-1-yl)naphtho(1,8a-c)furan-3,5-diyl dibutanoate","C548433","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27067367","Preclinical anticancer effectiveness of a fraction from Casearia sylvestris and its component Casearin X: in vivo and ex vivo methods and microscopy examinations.","27067367",136]
["1-(benzofuran-2-yl(phenyl)methyl)-3-(2-(4-methoxyphenyl)-2-oxoethyl)-1H-benzo(d)imidazol-3-ium","1-(benzofuran-2-yl(phenyl)methyl)-3-(2-(4-methoxyphenyl)-2-oxoethyl)-1H-benzo(d)imidazol-3-ium","C583775","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23353748","Design, synthesis and biological evaluation of novel hybrid compounds of imidazole scaffold-based 2-benzylbenzofuran as potent anticancer agents.","23353748",136]
["1-(benzofuran-2-yl(phenyl)methyl)-3-(2-(naphthalen-2-yl)-2-oxoethyl)-1H-benzo(d)imidazol-3-ium","1-(benzofuran-2-yl(phenyl)methyl)-3-(2-(naphthalen-2-yl)-2-oxoethyl)-1H-benzo(d)imidazol-3-ium","C583774","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23353748","Design, synthesis and biological evaluation of novel hybrid compounds of imidazole scaffold-based 2-benzylbenzofuran as potent anticancer agents.","23353748",136]
["1-(benzofuran-2-yl)-2-propylaminopentane","1-(benzofuran-2-yl)-2-propylaminopentane","C404200","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2004,"15102525","Neuroprotective function of R-(-)-1-(benzofuran-2-yl)-2-propylaminopentane, [R-(-)-BPAP], against apoptosis induced by N-methyl(R)salsolinol, an endogenous dopaminergic neurotoxin, in human dopaminergic neuroblastoma SH-SY5Y cells.","15102525",136]
["1-(carboxymethylthio)tetradecane","1-(carboxymethylthio)tetradecane","C062078","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2001,"11698335","Tetradecylthioacetic acid inhibits growth of rat glioma cells ex vivo and in vivo via PPAR-dependent and PPAR-independent pathways.","11698335",136]
["1-(carboxymethylthio)tetradecane","1-(carboxymethylthio)tetradecane","C062078","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2003,"12713457","Immunomodulating effects of 3-thia fatty acids in activated peripheral blood mononuclear cells.","12713457",136]
["1-(carboxymethylthio)tetradecane","1-(carboxymethylthio)tetradecane","C062078","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2003,"12890534","Mitochondrial-targeted fatty acid analog induces apoptosis with selective loss of mitochondrial glutathione in promyelocytic leukemia cells.","12890534",136]
["1-(carboxymethylthio)tetradecane","1-(carboxymethylthio)tetradecane","C062078","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2006,"16740779","A bioactively modified fatty acid improves survival and impairs metastasis in preclinical models of acute leukemia.","16740779",136]
["1-(carboxymethylthio)tetradecane","1-(carboxymethylthio)tetradecane","C062078","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2007,"18287814","Effect of dietary tetradecylthioacetic acid on colon cancer growth studied by dynamic contrast enhanced MRI.","18287814",136]
["1-(carboxymethylthio)tetradecane","1-(carboxymethylthio)tetradecane","C062078","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2007,"18287814","Effect of dietary tetradecylthioacetic acid on colon cancer growth studied by dynamic contrast enhanced MRI.","18287814",136]
["1-(carboxymethylthio)tetradecane","1-(carboxymethylthio)tetradecane","C062078","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"22027281","Tetradecylthioacetic acid inhibits proliferation of human SW620 colon cancer cells--gene expression profiling implies endoplasmic reticulum stress.","22027281",136]
["1-(carboxymethylthio)tetradecane","1-(carboxymethylthio)tetradecane","C062078","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22934973","Effects of local delivery of tetradecylthioacetic acid within the injured coronary vessel wall.","22934973",136]
["1-(chrysen-6-yl)-3-(4-nitrophenyl)thiourea","1-(chrysen-6-yl)-3-(4-nitrophenyl)thiourea","C000624346","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28844711","Novel flexible heteroarotinoid, SL-1-18, promotes ERα degradation to inhibit breast cancer cell growth.","28844711",136]
["1-(chrysen-6-yl)-3-(4-nitrophenyl)thiourea","1-(chrysen-6-yl)-3-(4-nitrophenyl)thiourea","C000624346","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28844711","Novel flexible heteroarotinoid, SL-1-18, promotes ERα degradation to inhibit breast cancer cell growth.","28844711",136]
["1-(di-(2-pyridyl)methylene)-5-salicylidenethiocarbonohydrazide","1-(di-(2-pyridyl)methylene)-5-salicylidenethiocarbonohydrazide","C066715","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1990,"2271075","Spectrophotometric determination of bismuth in pharmaceutical preparations using 1-[di(2-pyridyl)--methylene]-5-salicylidene-thiocarbonohydrazide.","2271075",136]
["1-(ferrocenemethyl)-1,4,7,10-tetraazacyclododecane","1-(ferrocenemethyl)-1,4,7,10-tetraazacyclododecane","C520109","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"17284025","Recognition of thymine and related nucleosides by a Zn(II)-cyclen complex bearing a ferrocenyl pendant.","17284025",136]
["1-(hydroxymethyl)-6,7,8-trihydroxyindolizidine","1-(hydroxymethyl)-6,7,8-trihydroxyindolizidine","C524717","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2007,"17918922","Synthesis of 1-deoxy-1-hydroxymethyl- and 1-deoxy-1-epi-hydroxymethyl castanospermine as new potential immunomodulating agents.","17918922",136]
["1-(methylimino-N-oxy)-6-(2-morpholinoethoxy)-3-phenyl-1H-indene-2-carboxylic acid ethyl ester","1-(methylimino-N-oxy)-6-(2-morpholinoethoxy)-3-phenyl-1H-indene-2-carboxylic acid ethyl ester","C513115","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2006,"16806087","Differential anti-proliferative actions of peroxisome proliferator-activated receptor-gamma agonists in MCF-7 breast cancer cells.","16806087",136]
["1-(methylimino-N-oxy)-6-(2-morpholinoethoxy)-3-phenyl-1H-indene-2-carboxylic acid ethyl ester","1-(methylimino-N-oxy)-6-(2-morpholinoethoxy)-3-phenyl-1H-indene-2-carboxylic acid ethyl ester","C513115","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"19896472","Anti-allergic function and regulatory mechanisms of KR62980 in allergen-induced airway inflammation.","19896472",136]
["1-(methylimino-N-oxy)-6-(2-morpholinoethoxy)-3-phenyl-1H-indene-2-carboxylic acid ethyl ester","1-(methylimino-N-oxy)-6-(2-morpholinoethoxy)-3-phenyl-1H-indene-2-carboxylic acid ethyl ester","C513115","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"21769449","Anti-angiogenic action of PPARγ ligand in human umbilical vein endothelial cells is mediated by PTEN upregulation and VEGFR-2 downregulation.","21769449",136]
["1-(methylimino-N-oxy)-6-(2-morpholinoethoxy)-3-phenyl-1H-indene-2-carboxylic acid ethyl ester","1-(methylimino-N-oxy)-6-(2-morpholinoethoxy)-3-phenyl-1H-indene-2-carboxylic acid ethyl ester","C513115","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21769449","Anti-angiogenic action of PPARγ ligand in human umbilical vein endothelial cells is mediated by PTEN upregulation and VEGFR-2 downregulation.","21769449",136]
["1-(N-(2-hydroxyethyl)acetamido)-2-hydroxylaminoimidazole","1-(N-(2-hydroxyethyl)acetamido)-2-hydroxylaminoimidazole","C049945","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1986,"3744941","The production of strand breaks in DNA in the presence of the hydroxylamine of SR-2508 (1-[N-(2-hydroxyethyl)acetamido]-2-nitroimidazole) at neutral pH.","3744941",136]
["1-(N-methyl-4,4'-bipyridinium)-1-(2-hydroxy-5-nitrophenyl)methane","1-(N-methyl-4,4'-bipyridinium)-1-(2-hydroxy-5-nitrophenyl)methane","C066054","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1990,"2215477","The importance of electrostatic interactions in the binding of paraquat to its elicited monoclonal antibody.","2215477",136]
["1-(p-fluorphenacyl)-2-methyl-4-nitroimidazole","1-(p-fluorphenacyl)-2-methyl-4-nitroimidazole","C500177","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2004,"15046779","Cytogenetic study of metronidazole and three metronidazole analogues in cultured human lymphocytes with and without metabolic activation.","15046779",136]
["1-(p-methoxyphenacyl)-2-methyl-4-nitroimidazole","1-(p-methoxyphenacyl)-2-methyl-4-nitroimidazole","C500178","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2004,"15046779","Cytogenetic study of metronidazole and three metronidazole analogues in cultured human lymphocytes with and without metabolic activation.","15046779",136]
["1-(p-methylphenacyl)-2-methyl-4-nitro imidazole","1-(p-methylphenacyl)-2-methyl-4-nitro imidazole","C500176","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2004,"15046779","Cytogenetic study of metronidazole and three metronidazole analogues in cultured human lymphocytes with and without metabolic activation.","15046779",136]
["1-(propoxymethyl)maleimide","1-(propoxymethyl)maleimide","C557741","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"21220316","Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress.","21220316",136]
["1-(propoxymethyl)maleimide","1-(propoxymethyl)maleimide","C557741","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24691427","Small molecule MIRA-1 induces in vitro and in vivo anti-myeloma activity and synergizes with current anti-myeloma agents.","24691427",136]
["1-(propoxymethyl)maleimide","1-(propoxymethyl)maleimide","C557741","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25617798","Acute cytotoxicity of MIRA-1/NSC19630, a mutant p53-reactivating small molecule, against human normal and cancer cells via a caspase-9-dependent apoptosis.","25617798",136]
["1-(propoxymethyl)maleimide","1-(propoxymethyl)maleimide","C557741","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21220316","Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress.","21220316",136]
["1-(tert-butylamino)-3-(5-tert-butylaminomethyl-2-methoxyphenoxy)propan-2-ol","1-(tert-butylamino)-3-(5-tert-butylaminomethyl-2-methoxyphenoxy)propan-2-ol","C519077","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2007,"17331347","Beta-blocking activity of PP-34, a newly synthesized aryloxypropanolamine derivative, and its cardioprotective effect against ischaemia/reperfusion injury in laboratory animals.","17331347",136]
["1-(tetrahydro-4-hydroxy-5-(hydroxymethyl)furan-2-yl)pyrimidine-2,4(1H,3H)-dione","1-(tetrahydro-4-hydroxy-5-(hydroxymethyl)furan-2-yl)pyrimidine-2,4(1H,3H)-dione","C539903","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2008,"19260333","Identification of cytotoxic constituent of Indonesian sponge Kaliapsis sp. (Bowerbank).","19260333",136]
["1,(N2)-ethenoguanine","1,(N2)-ethenoguanine","C085534","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,1,2006,"16780368","Translesion synthesis across 1,N2-ethenoguanine by human DNA polymerases.","16780368",136]
["1,(N2)-ethenoguanine","1,(N2)-ethenoguanine","C085534","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,1,1997,"9166777","Misincorporation of dNTPs opposite 1,N2-ethenoguanine and 5,6,7,9-tetrahydro-7-hydroxy-9-oxoimidazo[1,2-a]purine in oligonucleotides by Escherichia coli polymerases I exo- and II exo-, T7 polymerase exo-, human immunodeficiency virus-1 reverse transcriptase, and rat polymerase beta.","9166777",136]
["1,1'-((((5-(trifluoromethyl)pyrimidine-2,4-diyl)bis(azanediyl))bis(3-methoxy-4,1-phenylene))bis(piperazine-4,1-diyl))bis(ethan-1-one)","1,1'-((((5-(trifluoromethyl)pyrimidine-2,4-diyl)bis(azanediyl))bis(3-methoxy-4,1-phenylene))bis(piperazine-4,1-diyl))bis(ethan-1-one)","C000597555","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24446111","ALK inhibitors of bis-ortho-alkoxy-para-piperazinesubstituted-pyrimidines and -triazines for cancer treatment.","24446111",136]
["1,1'-((1,1'-biphenyl)-4,4'-diyl)bis(3-(piperidin-1-yl)propan-1-one)dihydrochloride","1,1'-((1,1'-biphenyl)-4,4'-diyl)bis(3-(piperidin-1-yl)propan-1-one)dihydrochloride","C000614891","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27498773","DL0410, a novel dual cholinesterase inhibitor, protects mouse brains against Aβ-induced neuronal damage via the Akt/JNK signaling pathway.","27498773",136]
["1,1'-((4,4,7,7-tetramethyl)-4,7-diazaundecamethylene)bis-4-(3-methyl-2,3-dihydro(benzo-1,3-oxazole)-2-methylidene)quinolinium","1,1'-((4,4,7,7-tetramethyl)-4,7-diazaundecamethylene)bis-4-(3-methyl-2,3-dihydro(benzo-1,3-oxazole)-2-methylidene)quinolinium","C075296","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1994,"7527190","In situ screening assay for cell viability using a dimeric cyanine nucleic acid stain.","7527190",136]
["1,1'-((propane-1,3-diyl)dioxy)bis(7-methoxy-2-methylidene-1,2,3,10,11,11a-hexahydro-5H-pyrrolo(2,1-c)(1,4)benzodiazepin-5,11-dione)","1,1'-((propane-1,3-diyl)dioxy)bis(7-methoxy-2-methylidene-1,2,3,10,11,11a-hexahydro-5H-pyrrolo(2,1-c)(1,4)benzodiazepin-5,11-dione)","C423343","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2004,"15374993","The novel sequence-specific DNA cross-linking agent SJG-136 (NSC 694501) has potent and selective in vitro cytotoxicity in human B-cell chronic lymphocytic leukemia cells with evidence of a p53-independent mechanism of cell kill.","15374993",136]
["1,1'-(1,3-phenylene)bis(3-(3,5-dimethylphenyl)thiourea)","1,1'-(1,3-phenylene)bis(3-(3,5-dimethylphenyl)thiourea)","C000595180","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24755487","A novel synthetic 1,3-phenyl bis-thiourea compound targets microtubule polymerization to cause cancer cell death.","24755487",136]
["1,1'-(4,4,7,7-tetramethyl-4,7-diazaundecamethylene)bis-4-(3-methyl-2,3-dihydro(benzo-1,3-thiazole)-2-methylidene)quinolinium","1,1'-(4,4,7,7-tetramethyl-4,7-diazaundecamethylene)bis-4-(3-methyl-2,3-dihydro(benzo-1,3-thiazole)-2-methylidene)quinolinium","C075295","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2006,"16447044","Detection of oncoprotein platelet-derived growth factor using a fluorescent signaling complex of an aptamer and TOTO.","16447044",136]
["1,1'-(biphenyl-4,4'-diyl)-bis(3-(dimethylamino)propan-1-one)","1,1'-(biphenyl-4,4'-diyl)-bis(3-(dimethylamino)propan-1-one)","C000595502","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24350730","Antioxidant and antiapoptotic effects of 1,1'-(biphenyl-4,4'-diyl)-bis(3-(dimethylamino)-propan-1-one) on protecting PC12 cells from Aβ-induced injury.","24350730",136]
["1,1',1'',1'''-(ethylenedinitrilo)tetra-2-propanol","1,1',1'',1'''-(ethylenedinitrilo)tetra-2-propanol","C010629","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2009,"19540041","Sorption of Cu(II) complexes with ligands tartrate, glycine and quadrol by chitosan.","19540041",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C1347,B1347)","v":"1,1',1'',1'''-(ethylenedinitrilo)tetra-2-propanol"},"1,1',1'',1'''-(ethylenedinitrilo)tetra-2-propanol","C010629","1_MIE",867,1,"Intracellular pH","Decrease",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J1347,K1347)","v":"Hydrogen-Ion Concentration"},"D006863","Hydrogen-Ion Concentration",2,2,2010,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q1347,Q1347)","v":"19896768"},"Decontamination of solutions containing Cu(II) and ligands tartrate, glycine and quadrol using metallic iron.","19896768",136]
["1,1,1',1'-tetramethyl (60)fullerenodipyrrolidinium","1,1,1',1'-tetramethyl (60)fullerenodipyrrolidinium","C000593228","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"25063029","Pyrrolidinium fullerene induces apoptosis by activation of procaspase-9 via suppression of Akt in primary effusion lymphoma.","25063029",136]
["1,1,1,2-tetrachloroethane","1,1,1,2-tetrachloroethane","C031336","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"22780331","Influence of anionic cosolutes and pH on nanoscale zerovalent iron longevity: time scales and mechanisms of reactivity loss toward 1,1,1,2-tetrachloroethane and Cr(VI).","22780331",136]
["1,1,1,2-tetrafluoro-2-chloroethane","1,1,1,2-tetrafluoro-2-chloroethane","C072959","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2001,"11548120","Investigations on the liver toxicity of a blend of HCFC-123 (2,2-dichloro-1,1,1-trifluoroethane) and HCFC-124 (2-chloro-1,1,1,2-tetrafluoroethane) in guinea-pigs.","11548120",136]
["1,1,1,3,3-pentachloroacetone","1,1,1,3,3-pentachloroacetone","C054043","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1987,"3664010","Effects of pH and temperature on the degradation of chloroacetones that are mutagenic.","3664010",136]
["1,1,1,3,3-pentafluoropropane","1,1,1,3,3-pentafluoropropane","C403631","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2013,"23332645","Unexpected brain lesions in lactating Sprague-Dawley rats in a Two-generation Inhalation Reproductive Toxicity Study with pentafluoropropane (HFC-245fa).","23332645",136]
["1,1,1-trichloroethane","1,1,1-trichloroethane","C024566","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Atrophy","D001284","Atrophy",1,1,1996,"8791934","MR in trichloroethane poisoning.","8791934",136]
["1,1,1-trichloroethane","1,1,1-trichloroethane","C024566","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2003,"14717199","Investigation of the inhibitory effect of silica on the degradation of 1,1,1-trichloroethane by granular iron.","14717199",136]
["1,1,1-trichloroethane","1,1,1-trichloroethane","C024566","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2009,"18621480","Effects of transition metal and sulfide on the reductive dechlorination of carbon tetrachloride and 1,1,1-trichloroethane by FeS.","18621480",136]
["1,1,1-trichloroethane","1,1,1-trichloroethane","C024566","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"22634553","Reductive dechlorination of chlorinated hydrocarbons as non-aqueous phase liquid (NAPL): preliminary investigation on effects of cement doses.","22634553",136]
["1,1,1-trichloroethane","1,1,1-trichloroethane","C024566","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1989,"2729985","Biotransformation of 1,1,1-trichloroethane, trichloromethane, and tetrachloromethane by a Clostridium sp.","2729985",136]
["1,1,1-trichloroethane","1,1,1-trichloroethane","C024566","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Nasal Mucosa","D009297","Nasal Mucosa",1,2,1999,"10541915","The exposure of healthy volunteers to 200 ppm 1,1,1-trichloroethane increases the concentration of proinflammatory cytokines in nasal secretions.","10541915",136]
["1,1,1-trichloroethane","1,1,1-trichloroethane","C024566","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,1983,"6662442","Fatal poisoning by 1,1,1-trichloroethane after prolonged survival.","6662442",136]
["1,1,1-trifluoro-2-chloroethane","1,1,1-trifluoro-2-chloroethane","C016800","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1983,"6872099","One-electron reduction of halothane and formation of halide ions in aqueous solutions.","6872099",136]
["1,1,1-trifluoro-4-phenylbutan-2-one","1,1,1-trifluoro-4-phenylbutan-2-one","C059358","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,2,2002,"12161116","Quantum chemical- and 3-D-QSAR (CoMFA) studies of benzalacetones and 1,1,1-trifluoro-4-phenyl-3-buten-2-ones.","12161116",136]
["1,1,1-trifluoro-6-(naphthalen-2-yl)hexan-2-one","1,1,1-trifluoro-6-(naphthalen-2-yl)hexan-2-one","C587596","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23977134","Characterization of FKGK18 as inhibitor of group VIA Ca2+-independent phospholipase A2 (iPLA2β): candidate drug for preventing beta-cell apoptosis and diabetes.","23977134",136]
["1,1,2,2-tetrachloroethane","1,1,2,2-tetrachloroethane","C015530","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2008,"18068753","Dechlorination of trichloroethylene formed from 1,1,2,2-tetrachloroethane by dehydrochlorination in Portland cement slurry including Fe(II).","18068753",136]
["1,1,2,2-tetrachloroethane","1,1,2,2-tetrachloroethane","C015530","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"18075113","Comment on \"1,1,2,2-Tetrachloroethane reactions with OH-, Cr(II), granular iron, and a copper-iron bimetal: insights from product formation and associated carbon isotope fractionation\".","18075113",136]
["1,1,2,2-tetrachloroethane","1,1,2,2-tetrachloroethane","C015530","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"24096531","Development of an attached-growth process for the on-site bioremediation of an aquifer polluted by chlorinated solvents.","24096531",136]
["1,1,2,2-tetrachloroethane","1,1,2,2-tetrachloroethane","C015530","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"24617768","Catalytic effects of functionalized carbon nanotubes on dehydrochlorination of 1,1,2,2-tetrachloroethane.","24617768",136]
["1,1',2,2'-tetraoleoylcardiolipin","1,1',2,2'-tetraoleoylcardiolipin","C519576","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2017,"27984017","Magic angle spinning 31P NMR spectroscopy reveals two essentially identical ionization states for the cardiolipin phosphates in phospholipid liposomes.","27984017",136]
["1,1,2-trichloro-3,3,3-trifluoro-1-propene","1,1,2-trichloro-3,3,3-trifluoro-1-propene","C060270","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,1994,"7717868","Studies on the comparative toxicity of S-(1,2-dichlorovinyl)-L-cysteine, S-(1,2-dichlorovinyl)-L-homocysteine and 1,1,2-trichloro-3,3,3-trifluoro-1-propene in the Fischer 344 rat.","7717868",136]
["1,1',3,3,3',3'-hexamethylindotricarbocyanine","1,1',3,3,3',3'-hexamethylindotricarbocyanine","C053313","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2002,"12360577","A novel apoptosis research method with imaging-combined flow cytometer and HITC or IR-125 staining.","12360577",136]
["1,1',3,3,3',3'-hexamethylindotricarbocyanine","1,1',3,3,3',3'-hexamethylindotricarbocyanine","C053313","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2005,"16138693","Fluorimetric studies and noncovalent labeling of protein with the near-infrared dye HITCI for analysis by CE-LIF.","16138693",136]
["1,1,3,3-tetramethylguanidine","1,1,3,3-tetramethylguanidine","C477069","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"24560369","Design of functional guanidinium ionic liquid aqueous two-phase systems for the efficient purification of protein.","24560369",136]
["1,1,3,3-tetramethylurea","1,1,3,3-tetramethylurea","C004168","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Olfactory Mucosa","D009831","Olfactory Mucosa",1,2,2001,"11665645","Inhalation toxicity of tetramethylurea in rats.","11665645",136]
["1,1,3-tris(3-indolyl)cyclohexane","1,1,3-tris(3-indolyl)cyclohexane","C531174","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2008,"18618576","Novel 2-step synthetic indole compound 1,1,3-tri(3-indolyl)cyclohexane inhibits cancer cell growth in lung cancer cells and xenograft models.","18618576",136]
["1,1,3-tris(3-indolyl)cyclohexane","1,1,3-tris(3-indolyl)cyclohexane","C531174","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2008,"18618576","Novel 2-step synthetic indole compound 1,1,3-tri(3-indolyl)cyclohexane inhibits cancer cell growth in lung cancer cells and xenograft models.","18618576",136]
["1,1,4,4-butanetetracarboxylic acid","1,1,4,4-butanetetracarboxylic acid","C065777","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1990,"2401602","Synthesis and characterization of 1,1,4,4-butanetetracarboxylic acid. A di-gamma-carboxyglutamic acid (GlaGla) analogue.","2401602",136]
["1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-N5-(2-phenylpropyl)-N5'-(2-phenylpropyl)-2,2'-binaphthyl-5,5'-dicarboxamide","1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-N5-(2-phenylpropyl)-N5'-(2-phenylpropyl)-2,2'-binaphthyl-5,5'-dicarboxamide","C550162","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2010,"20443627","BI-97C1, an optically pure Apogossypol derivative as pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.","20443627",136]
["1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-N5-(2-phenylpropyl)-N5'-(2-phenylpropyl)-2,2'-binaphthyl-5,5'-dicarboxamide","1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-N5-(2-phenylpropyl)-N5'-(2-phenylpropyl)-2,2'-binaphthyl-5,5'-dicarboxamide","C550162","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"21555592","Apogossypol derivative BI-97C1 (Sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to mda-7/IL-24-mediated toxicity.","21555592",136]
["1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-N5-(2-phenylpropyl)-N5'-(2-phenylpropyl)-2,2'-binaphthyl-5,5'-dicarboxamide","1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-N5-(2-phenylpropyl)-N5'-(2-phenylpropyl)-2,2'-binaphthyl-5,5'-dicarboxamide","C550162","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22904682","Sabutoclax, a Mcl-1 antagonist, inhibits tumorigenesis in transgenic mouse and human xenograft models of prostate cancer.","22904682",136]
["1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-N5-(2-phenylpropyl)-N5'-(2-phenylpropyl)-2,2'-binaphthyl-5,5'-dicarboxamide","1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-N5-(2-phenylpropyl)-N5'-(2-phenylpropyl)-2,2'-binaphthyl-5,5'-dicarboxamide","C550162","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23633928","Sabutoclax (BI97C1) and BI112D1, putative inhibitors of MCL-1, induce mitochondrial fragmentation either upstream of or independent of apoptosis.","23633928",136]
["1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-N5-(2-phenylpropyl)-N5'-(2-phenylpropyl)-2,2'-binaphthyl-5,5'-dicarboxamide","1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-N5-(2-phenylpropyl)-N5'-(2-phenylpropyl)-2,2'-binaphthyl-5,5'-dicarboxamide","C550162","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"26009874","Mcl-1 is an important therapeutic target for oral squamous cell carcinomas.","26009874",136]
["1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-N5-(2-phenylpropyl)-N5'-(2-phenylpropyl)-2,2'-binaphthyl-5,5'-dicarboxamide","1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-N5-(2-phenylpropyl)-N5'-(2-phenylpropyl)-2,2'-binaphthyl-5,5'-dicarboxamide","C550162","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"26032425","Pancreatic Cancer Combination Therapy Using a BH3 Mimetic and a Synthetic Tetracycline.","26032425",136]
["1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-N5-(2-phenylpropyl)-N5'-(2-phenylpropyl)-2,2'-binaphthyl-5,5'-dicarboxamide","1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-N5-(2-phenylpropyl)-N5'-(2-phenylpropyl)-2,2'-binaphthyl-5,5'-dicarboxamide","C550162","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20443627","BI-97C1, an optically pure Apogossypol derivative as pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.","20443627",136]
["1,10-phenanthroline","1,10-phenanthroline","C025205","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2000,"11142693","Apoptosis-inducing oxovanadium(IV) complexes of 1,10-phenanthroline against human ovarian cancer.","11142693",136]
["1,10-phenanthroline","1,10-phenanthroline","C025205","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2003,"12609704","Suppression by iron chelator phenanthroline of sodium chloride-enhanced gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats.","12609704",136]
["1,10-phenanthroline","1,10-phenanthroline","C025205","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2007,"17624183","Effects of copper-phenanthroline on pentachlorophenol-induced adaptation and cell death of Escherichia coli.","17624183",136]
["1,10-phenanthroline","1,10-phenanthroline","C025205","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"20674559","H(2)O(2) preferentially synergizes with nitroprusside to induce apoptosis associated with superoxide dismutase dysregulation in human melanoma irrespective of p53 status: Antagonism by o-phenanthroline.","20674559",136]
["1,10-phenanthroline","1,10-phenanthroline","C025205","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"21448489","Rhenium(IV) compounds inducing apoptosis in cancer cells.","21448489",136]
["1,10-phenanthroline","1,10-phenanthroline","C025205","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"21515032","Human serum albumin binding and cytotoxicity studies of surfactant-cobalt(III) complex containing 1,10-phenanthroline ligand.","21515032",136]
["1,10-phenanthroline","1,10-phenanthroline","C025205","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"21815775","Studies on the cytotoxic, apoptotic and antitumoral effects of Au(III) and Pt(II) complexes of 1, 10-phenanthroline on V79 379A and A549 cell lines.","21815775",136]
["1,10-phenanthroline","1,10-phenanthroline","C025205","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2012,"22172699","Imidazo [4,5f][1,10] phenanthroline derivatives as inhibitor of c-myc gene expression in A549 cells via NF-κB pathway.","22172699",136]
["1,10-phenanthroline","1,10-phenanthroline","C025205","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"23053530","1,10-Phenanthroline promotes copper complexes into tumor cells and induces apoptosis by inhibiting the proteasome activity.","23053530",136]
["1,10-phenanthroline","1,10-phenanthroline","C025205","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23178222","Lethal synergism between organic and inorganic wood preservatives via formation of an unusual lipophilic ternary complex.","23178222",136]
["1,10-phenanthroline","1,10-phenanthroline","C025205","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"25092524","FPDHP, a novel anticancer agent, induces cell detachment and caspase-dependent apoptosis in Caki cells.","25092524",136]
["1,10-phenanthroline","1,10-phenanthroline","C025205","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25698398","Necroptosis-inducing rhenium(V) oxo complexes.","25698398",136]
["1,10-phenanthroline","1,10-phenanthroline","C025205","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27278680","Anticancer activity and computational modeling of ternary copper (II) complexes with 3-indolecarboxylic acid and 1,10-phenanthroline.","27278680",136]
["1,10-phenanthroline","1,10-phenanthroline","C025205","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"27696716","In vitro evaluation of apoptotic effect of bis(acetylacetonato-k2 O,O')(1,10-phenanthroline-k2  N,N')Zn(II) complex.","27696716",136]
["1,10-phenanthroline","1,10-phenanthroline","C025205","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"28033401","Antitumor Activity of 2,9-Di-Sec-Butyl-1,10-Phenanthroline.","28033401",136]
["1,10-phenanthroline","1,10-phenanthroline","C025205","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28415735","Salicylate •Phenanthroline copper (II) complex induces apoptosis in triple-negative breast cancer cells.","28415735",136]
["1,10-phenanthroline","1,10-phenanthroline","C025205","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,1996,"8546678","1,10-Phenanthroline stimulates internucleosomal DNA fragmentation in isolated rat-liver nuclei by promoting the redox activity of endogenous copper ions.","8546678",136]
["1,10-phenanthroline","1,10-phenanthroline","C025205","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,1997,"9180259","Induction of glutathione synthetase by 1,10-phenanthroline.","9180259",136]
["1,10-phenanthroline","1,10-phenanthroline","C025205","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,1999,"9916012","Spermicidal activity of oxovanadium(IV) complexes of 1, 10-phenanthroline, 2,2'-bipyridyl, 5'-bromo-2'-hydroxyacetophenone and derivatives in humans.","9916012",136]
["1,10-phenanthroline","1,10-phenanthroline","C025205","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2005,"15761840","Cytostatic activity of 1,10-phenanthroline derivatives generated by the clip-phen strategy.","15761840",136]
["1,10-phenanthroline","1,10-phenanthroline","C025205","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20558101","Interaction studies between a 1,10-phenanthroline adduct of palladium(II) dithiocarbamate anti-tumor complex and calf thymus DNA. A synthesis spectral and in-vitro study.","20558101",136]
["1,10-phenanthroline","1,10-phenanthroline","C025205","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20674559","H(2)O(2) preferentially synergizes with nitroprusside to induce apoptosis associated with superoxide dismutase dysregulation in human melanoma irrespective of p53 status: Antagonism by o-phenanthroline.","20674559",136]
["1,10-phenanthroline","1,10-phenanthroline","C025205","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21692452","Two new ternary complexes of copper(II) with tetracycline or doxycycline and 1,10-phenanthroline and their potential as antitumoral: cytotoxicity and DNA cleavage.","21692452",136]
["1,10-phenanthroline","1,10-phenanthroline","C025205","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"21815775","Studies on the cytotoxic, apoptotic and antitumoral effects of Au(III) and Pt(II) complexes of 1, 10-phenanthroline on V79 379A and A549 cell lines.","21815775",136]
["1,10-phenanthroline","1,10-phenanthroline","C025205","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2012,"22172699","Imidazo [4,5f][1,10] phenanthroline derivatives as inhibitor of c-myc gene expression in A549 cells via NF-κB pathway.","22172699",136]
["1,10-phenanthroline","1,10-phenanthroline","C025205","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22246791","Spectroscopic characterization of an oxovanadium(IV) complex of oxodiacetic acid and o-phenanthroline. Bioactivity on osteoblast-like cells in culture.","22246791",136]
["1,10-phenanthroline","1,10-phenanthroline","C025205","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22825726","[Zn(phen)(O,N,O)(H2O)] and [Zn(phen)(O,N)(H2O)] with O,N,O is 2,6-dipicolinate and N,O is L-threoninate: synthesis, characterization, and biomedical properties.","22825726",136]
["1,10-phenanthroline","1,10-phenanthroline","C025205","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"23053530","1,10-Phenanthroline promotes copper complexes into tumor cells and induces apoptosis by inhibiting the proteasome activity.","23053530",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C1411,B1411)","v":"1,10-phenanthroline"},"1,10-phenanthroline","C025205","3_KE",870,3,"Cell Proliferation","Increase",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J1411,K1411)","v":"Cell Proliferation"},"D049109","Cell Proliferation",1,2,2013,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q1411,Q1411)","v":"23299967"},"The DNA binding site specificity and antiproliferative property of ternary Pt(II) and Zn(II) complexes of phenanthroline and N,N'-ethylenediaminediacetic acid.","23299967",136]
["1,10-phenanthroline","1,10-phenanthroline","C025205","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27278680","Anticancer activity and computational modeling of ternary copper (II) complexes with 3-indolecarboxylic acid and 1,10-phenanthroline.","27278680",136]
["1,10-phenanthroline","1,10-phenanthroline","C025205","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"27917615","Design, Synthesis, and Evaluation of 2,9-Bis[(substituted-aminomethyl)phenyl]-1,10-phenanthroline Derivatives as G-Quadruplex Ligands.","27917615",136]
["1,10-phenanthroline","1,10-phenanthroline","C025205","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28374136","High cytotoxicity of vanadium(IV) complexes with 1,10-phenanthroline and related ligands is due to decomposition in cell culture medium.","28374136",136]
["1,10-phenanthroline","1,10-phenanthroline","C025205","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2002,"11931969","Spectroscopy, cytotoxicity and DNA-binding of the lanthanum(III) complex of an L-valine derivative of 1,10-phenanthroline.","11931969",136]
["1,10-phenanthroline","1,10-phenanthroline","C025205","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2002,"12062119","DNA-fiber EPR study of the orientation of Cu(II) complexes of 1,10-phenanthroline and its derivatives bound to DNA: mono(phenanthroline)-copper(II) and its ternary complexes with amino acids.","12062119",136]
["1,10-phenanthroline","1,10-phenanthroline","C025205","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1965,"14329447","ISOLATION AND CHARACTERIZATION OF THE CYANIDE-RESISTANT AND AZIDE-RESISTANT CATALASE OF LACTOBACILLUS PLANTARUM.","14329447",136]
["1,10-phenanthroline","1,10-phenanthroline","C025205","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2003,"14518970","pH responsive Eu(III)-phenanthroline supramolecular conjugate: novel \"off-on-off\" luminescent signaling in the physiological pH range.","14518970",136]
["1,10-phenanthroline","1,10-phenanthroline","C025205","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2005,"15995744","Platinum(II) 1,10-phenanthroline complexes of acetylides containing redox-active groups.","15995744",136]
["1,10-phenanthroline","1,10-phenanthroline","C025205","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2005,"16043188","Apparent and partial specific adsorption of 1,10-phenanthroline on mixtures of Ca-montmorillonite, activated carbon, and silica gel.","16043188",136]
["1,10-phenanthroline","1,10-phenanthroline","C025205","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2008,"18177045","Enhanced metal ion selectivity of 2,9-di-(pyrid-2-yl)-1,10-phenanthroline and its use as a fluorescent sensor for cadmium(II).","18177045",136]
["1,10-phenanthroline","1,10-phenanthroline","C025205","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2009,"19615510","On-line solid phase extraction system using 1,10-phenanthroline immobilized on surfactant coated alumina for the flame atomic absorption spectrometric determination of copper and cadmium.","19615510",136]
["1,10-phenanthroline","1,10-phenanthroline","C025205","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2006,"20050566","Determination of hydroxyl radicals in TiO2/Ti photoelectrocatalytic oxidation system using Fe(phen)3(2+) spectrophotometry.","20050566",136]
["1,10-phenanthroline","1,10-phenanthroline","C025205","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2011,"21114311","Pyrophosphate-mediated magnetic interactions in Cu(II) coordination complexes.","21114311",136]
["1,10-phenanthroline","1,10-phenanthroline","C025205","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1990,"2186805","P+QA- and P+QB- charge recombinations in Rhodopseudomonas viridis chromatophores and in reaction centers reconstituted in phosphatidylcholine liposomes. Existence of two conformational states of the reaction centers and effects of pH and o-phenanthroline.","2186805",136]
["1,10-phenanthroline","1,10-phenanthroline","C025205","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2013,"24148415","Development and application of a ruthenium(II) complex-based photoluminescent and electrochemiluminescent dual-signaling probe for nitric oxide.","24148415",136]
["1,10-phenanthroline","1,10-phenanthroline","C025205","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2016,"26670687","A Fluorescent Hypochlorite Probe Built on 1,10-Phenanthroline Scaffold and its Ion Recognition Features.","26670687",136]
["1,10-phenanthroline","1,10-phenanthroline","C025205","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1997,"9437523","Ternary copper complexes and manganese (III) tetrakis(4-benzoic acid) porphyrin catalyze peroxynitrite-dependent nitration of aromatics.","9437523",136]
["1,10-phenanthroline","1,10-phenanthroline","C025205","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,1,1996,"8626692","Diverse cell surface protein ectodomains are shed by a system sensitive to metalloprotease inhibitors.","8626692",136]
["1,10-phenanthroline","1,10-phenanthroline","C025205","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,1,1996,"8844832","Engineering of DNA binding proteins into site-specific cutters: reactivity of Trp repressor-1,10-phenanthroline chimeras.","8844832",136]
["1,10-phenanthroline","1,10-phenanthroline","C025205","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2012,"22172699","Imidazo [4,5f][1,10] phenanthroline derivatives as inhibitor of c-myc gene expression in A549 cells via NF-κB pathway.","22172699",136]
["1,10-phenanthroline","1,10-phenanthroline","C025205","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,2,2015,"25698398","Necroptosis-inducing rhenium(V) oxo complexes.","25698398",136]
["1,10-phenanthroline","1,10-phenanthroline","C025205","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,1996,"8542589","Induction of tumor necrosis by delta-aminolevulinic acid and 1,10-phenanthroline photodynamic therapy.","8542589",136]
["1,10-phenanthroline-2,9-dicarboxylic acid","1,10-phenanthroline-2,9-dicarboxylic acid","C519844","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2009,"19603801","Strong metal ion size based selectivity of the highly preorganized ligand PDA (1,10-phenanthroline-2,9-dicarboxylic acid) with trivalent metal ions. A crystallographic, fluorometric, and thermodynamic study.","19603801",136]
["1,10-phenanthroline-5,6-dione","1,10-phenanthroline-5,6-dione","C037153","1_MIE",867,1,"Intracellular pH","Decrease","Acid-Base Equilibrium","D000136","Acid-Base Equilibrium",2,2,2004,"15252529","Acid-base equilibria of various oxidation states of aqua-ruthenium complexes with 1,10-phenanthroline-5,6-dione in aqueous media.","15252529",136]
["1,10-phenanthroline-5,6-dione","1,10-phenanthroline-5,6-dione","C037153","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24481501","Insights into the mechanisms underlying the antiproliferative potential of a Co(II) coordination compound bearing 1,10-phenanthroline-5,6-dione: DNA and protein interaction studies.","24481501",136]
["1,10-phenanthroline-5,6-dione","1,10-phenanthroline-5,6-dione","C037153","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"25238635","Novel copper(II) complexes as new promising antitumour agents. A crystal structure of [Cu(1,10-phenanthroline-5,6-dione)2(OH2)(OClO3)](ClO4).","25238635",136]
["1,10-phenanthroline-5,6-dione","1,10-phenanthroline-5,6-dione","C037153","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2004,"15252529","Acid-base equilibria of various oxidation states of aqua-ruthenium complexes with 1,10-phenanthroline-5,6-dione in aqueous media.","15252529",136]
["1,10-phenanthroline-vanadyl complex","1,10-phenanthroline-vanadyl complex","C091442","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1995,"7818512","Mechanism for a new antitumor vanadium complex: hydroxyl radical-dependent DNA cleavage by 1,10-phenanthroline-vanadyl complex in the presence of hydrogen peroxide.","7818512",136]
["1,12-benzoperylene","1,12-benzoperylene","C006718","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2001,"11227816","Polycyclic aromatic hydrocarbon-polluted dredged peat sediments and earthworms: a mutual interference.","11227816",136]
["1,12-bis(4-methyl-5-(2-hydroxyethyl)thiazol-3-ium-3-yl)dodecane","1,12-bis(4-methyl-5-(2-hydroxyethyl)thiazol-3-ium-3-yl)dodecane","C499114","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2009,"19303732","Rapid resolution liquid chromatography-mass spectrometry determination of SAR97276 in monkey matrices. Pharmacokinetics in rhesus monkey infected by Plasmodium cynomolgi.","19303732",136]
["1,12-diamino-3,6,9-triazadodecane","1,12-diamino-3,6,9-triazadodecane","C502960","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"19953281","Novel isosteric charge-deficient spermine analogue--1,12-diamino-3,6,9-triazadodecane: synthesis, pK(a) measurement and biological activity.","19953281",136]
["1,12-diamino-3,6,9-triazadodecane","1,12-diamino-3,6,9-triazadodecane","C502960","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20684609","Synthesis and biological characterization of novel charge-deficient spermine analogues.","20684609",136]
["1,12-diaziridinyl-4,9-diazadodecane","1,12-diaziridinyl-4,9-diazadodecane","C097784","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,1998,"9809992","Tumor-targeted apoptosis by a novel spermine analogue, 1,12-diaziridinyl-4,9-diazadodecane, results in therapeutic efficacy and enhanced radiosensitivity of human prostate cancer.","9809992",136]
["1,12-dimethylspermine","1,12-dimethylspermine","C073195","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25849284","Depletion of the polyamines spermidine and spermine by overexpression of spermidine/spermine N¹-acetyltransferase 1 (SAT1) leads to mitochondria-mediated apoptosis in mammalian cells.","25849284",136]
["1,12-dimethylspermine","1,12-dimethylspermine","C073195","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25849284","Depletion of the polyamines spermidine and spermine by overexpression of spermidine/spermine N¹-acetyltransferase 1 (SAT1) leads to mitochondria-mediated apoptosis in mammalian cells.","25849284",136]
["1,12-dodecamethylenediamine","1,12-dodecamethylenediamine","C016417","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2000,"10731035","Long chain diamines inhibit growth of C6 glioma cells according to their hydrophobicity. An in vitro and molecular modeling study.","10731035",136]
["1,12-dodecamethylenediamine","1,12-dodecamethylenediamine","C016417","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1983,"6679729","Stabilization of human prostatic acid phosphatase by cross-linking with diamines.","6679729",136]
["1,12-dodecamethylenediamine","1,12-dodecamethylenediamine","C016417","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Nasal Mucosa","D009297","Nasal Mucosa",1,2,2004,"15371059","Inhalation toxicology of fumed dodecanediamine.","15371059",136]
["1,12-dodecamethylenediamine","1,12-dodecamethylenediamine","C016417","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2004,"15371059","Inhalation toxicology of fumed dodecanediamine.","15371059",136]
["1,13-bis(8-quinolyl)-1,4,7,10,13-pentaoxatridecane","1,13-bis(8-quinolyl)-1,4,7,10,13-pentaoxatridecane","C000593036","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"24656367","Fabrication of a highly selective cadmium (II) sensor based on 1,13-bis(8-quinolyl)-1,4,7,10,13-pentaoxatridecane as a supramolecular ionophore.","24656367",136]
["1,14-bis(2,3-dihydroxybenzoyl)-5,10-bis(1-hydroxy-2-pyridon-6-oyl)-1,5,10,14-tetraazatetradecane","1,14-bis(2,3-dihydroxybenzoyl)-5,10-bis(1-hydroxy-2-pyridon-6-oyl)-1,5,10,14-tetraazatetradecane","C080800","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1993,"8386249","Specific sequestering agents for the actinides. 21. Synthesis and initial biological testing of octadentate mixed catecholate-hydroxypyridinonate ligands.","8386249",136]
["1,15-bis(ethylamino)-4,8,12-triazapentadecane","1,15-bis(ethylamino)-4,8,12-triazapentadecane","C094172","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"17887793","Polyamine analogues bind human serum albumin.","17887793",136]
["1,15-bis(N5-(3,3-(diphenyl)propyl)-N1-biguanido)-4,12-diazapentadecane","1,15-bis(N5-(3,3-(diphenyl)propyl)-N1-biguanido)-4,12-diazapentadecane","C000595073","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"23508577","The re-expression of the epigenetically silenced e-cadherin gene by a polyamine analogue lysine-specific demethylase-1 (LSD1) inhibitor in human acute myeloid leukemia cell lines.","23508577",136]
["1,1'-beta-D-glucopyranosyl-3,3'-bis(5-bromoindolyl)-octyl methane","1,1'-beta-D-glucopyranosyl-3,3'-bis(5-bromoindolyl)-octyl methane","C000598856","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25794856","A therapeutically relevant, 3,3'-diindolylmethane derivative NGD16 attenuates angiogenesis by targeting glucose regulated protein, 78kDa (GRP78).","25794856",136]
["1,1'-beta-D-glucopyranosyl-3,3'-bis(5-bromoindolyl)-octyl methane","1,1'-beta-D-glucopyranosyl-3,3'-bis(5-bromoindolyl)-octyl methane","C000598856","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2015,"25794856","A therapeutically relevant, 3,3'-diindolylmethane derivative NGD16 attenuates angiogenesis by targeting glucose regulated protein, 78kDa (GRP78).","25794856",136]
["1,1'-binaphthyl","1,1'-binaphthyl","C412330","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2011,"21751801","A selective, sensitive, and chromogenic chemodosimeter for cyanide based on the 1,1'-binaphthyl scaffold.","21751801",136]
["1,1'-binaphthyl-2,2'-diamine","1,1'-binaphthyl-2,2'-diamine","C500338","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2004,"15249957","Models for biological trinuclear copper clusters. Characterization and enantioselective catalytic oxidation of catechols by the copper(II) complexes of a chiral ligand derived from (S)-(-)-1,1'-binaphthyl-2,2'-diamine.","15249957",136]
["1,1'-binaphthyl-2,2'-diamine","1,1'-binaphthyl-2,2'-diamine","C500338","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2008,"19007474","Optimization of 12 chiral analytes with 8 polymeric surfactants.","19007474",136]
["1,1'-binaphthyl-2,2'-diyl hydrogen phosphate","1,1'-binaphthyl-2,2'-diyl hydrogen phosphate","C107195","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2008,"19007474","Optimization of 12 chiral analytes with 8 polymeric surfactants.","19007474",136]
["1,1-bis(3'-(5-methoxyindolyl))-1-(p-t-butylphenyl)indolesmethane","1,1-bis(3'-(5-methoxyindolyl))-1-(p-t-butylphenyl)indolesmethane","C500672","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2005,"15805291","A novel ring-substituted diindolylmethane,1,1-bis[3'-(5-methoxyindolyl)]-1-(p-t-butylphenyl) methane, inhibits extracellular signal-regulated kinase activation and induces apoptosis in acute myelogenous leukemia.","15805291",136]
["1,1-bis(3'-indolyl)-1-(4-biphenyl)methane","1,1-bis(3'-indolyl)-1-(4-biphenyl)methane","C505817","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2005,"16155208","1,1-Bis(3'-indolyl)-1-(p-substitutedphenyl)methanes are peroxisome proliferator-activated receptor gamma agonists but decrease HCT-116 colon cancer cell survival through receptor-independent activation of early growth response-1 and nonsteroidal anti-inflammatory drug-activated gene-1.","16155208",136]
["1,1-bis(3'-indolyl)-1-(4-biphenyl)methane","1,1-bis(3'-indolyl)-1-(4-biphenyl)methane","C505817","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"21129193","1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induce autophagic cell death in estrogen receptor negative breast cancer.","21129193",136]
["1,1-bis(3'-indolyl)-1-(4-biphenyl)methane","1,1-bis(3'-indolyl)-1-(4-biphenyl)methane","C505817","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"21597379","Chemopreventive effects of synthetic C-substituted diindolylmethanes originating from cruciferous vegetables in human oral cancer cells.","21597379",136]
["1,1-bis(3'-indolyl)-1-(4-biphenyl)methane","1,1-bis(3'-indolyl)-1-(4-biphenyl)methane","C505817","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2005,"16155208","1,1-Bis(3'-indolyl)-1-(p-substitutedphenyl)methanes are peroxisome proliferator-activated receptor gamma agonists but decrease HCT-116 colon cancer cell survival through receptor-independent activation of early growth response-1 and nonsteroidal anti-inflammatory drug-activated gene-1.","16155208",136]
["1,1-bis(3'-indolyl)-1-(4-biphenyl)methane","1,1-bis(3'-indolyl)-1-(4-biphenyl)methane","C505817","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2006,"16731770","1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit colon cancer cell and tumor growth through PPARgamma-dependent and PPARgamma-independent pathways.","16731770",136]
["1,1-bis(3'-indolyl)-1-(4-biphenyl)methane","1,1-bis(3'-indolyl)-1-(4-biphenyl)methane","C505817","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2007,"17764562","1,1-Bis(3'-indolyl)-1-(p-biphenyl)methane inhibits basal-like breast cancer growth in athymic nude mice.","17764562",136]
["1,1-bis(3'-indolyl)-1-(4-biphenyl)methane","1,1-bis(3'-indolyl)-1-(4-biphenyl)methane","C505817","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"19823826","Peroxisome proliferator-activated receptor gamma-dependent activity of indole ring-substituted 1,1-bis(3'-indolyl)-1-(p-biphenyl)methanes in cancer cells.","19823826",136]
["1,1-bis(3'-indolyl)-1-(4-biphenyl)methane","1,1-bis(3'-indolyl)-1-(4-biphenyl)methane","C505817","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"21129193","1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induce autophagic cell death in estrogen receptor negative breast cancer.","21129193",136]
["1,1-bis(3'-indolyl)-1-(4-biphenyl)methane","1,1-bis(3'-indolyl)-1-(4-biphenyl)methane","C505817","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21597379","Chemopreventive effects of synthetic C-substituted diindolylmethanes originating from cruciferous vegetables in human oral cancer cells.","21597379",136]
["1,1-bis(3'-indolyl)-1-(4-biphenyl)methane","1,1-bis(3'-indolyl)-1-(4-biphenyl)methane","C505817","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2010,"21129193","1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induce autophagic cell death in estrogen receptor negative breast cancer.","21129193",136]
["1,1-bis(3'-indolyl)-1-(4-chlorophenyl)methane","1,1-bis(3'-indolyl)-1-(4-chlorophenyl)methane","C534880","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23950896","Chemoprevention of skin cancer with 1,1-Bis (3'-indolyl)-1-(aromatic) methane analog through induction of the orphan nuclear receptor, NR4A2 (Nurr1).","23950896",136]
["1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane","1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane","C552530","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"20660371","Inactivation of the orphan nuclear receptor TR3/Nur77 inhibits pancreatic cancer cell and tumor growth.","20660371",136]
["1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane","1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane","C552530","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"26229035","Nuclear receptor 4A1 as a drug target for breast cancer chemotherapy.","26229035",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C1475,B1475)","v":"1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane"},"1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane","C552530","3_KE",870,3,"Cell Proliferation","Increase",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J1475,K1475)","v":"Cell Proliferation"},"D049109","Cell Proliferation",1,2,2015,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q1475,Q1475)","v":"26229035"},"Nuclear receptor 4A1 as a drug target for breast cancer chemotherapy.","26229035",136]
["1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane","1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane","C552530","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27144436","Nuclear receptor 4A1 (NR4A1) as a drug target for treating rhabdomyosarcoma (RMS).","27144436",136]
["1,1-bis(3'-indolyl)-1-(4-t-butylphenyl)methane","1,1-bis(3'-indolyl)-1-(4-t-butylphenyl)methane","C505816","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2005,"16155208","1,1-Bis(3'-indolyl)-1-(p-substitutedphenyl)methanes are peroxisome proliferator-activated receptor gamma agonists but decrease HCT-116 colon cancer cell survival through receptor-independent activation of early growth response-1 and nonsteroidal anti-inflammatory drug-activated gene-1.","16155208",136]
["1,1-bis(3'-indolyl)-1-(4-t-butylphenyl)methane","1,1-bis(3'-indolyl)-1-(4-t-butylphenyl)methane","C505816","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2006,"16985067","1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit ovarian cancer cell growth through peroxisome proliferator-activated receptor-dependent and independent pathways.","16985067",136]
["1,1-bis(3'-indolyl)-1-(4-t-butylphenyl)methane","1,1-bis(3'-indolyl)-1-(4-t-butylphenyl)methane","C505816","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2007,"18006776","1,1-bis(3'-indolyl)-1-(p-substitutedphenyl)methanes induce apoptosis and inhibit renal cell carcinoma growth.","18006776",136]
["1,1-bis(3'-indolyl)-1-(4-t-butylphenyl)methane","1,1-bis(3'-indolyl)-1-(4-t-butylphenyl)methane","C505816","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2008,"18085536","1,1-bis(3'-indolyl)-1-(p-substituted phenyl)methanes decrease mitochondrial membrane potential and induce apoptosis in endometrial and other cancer cell lines.","18085536",136]
["1,1-bis(3'-indolyl)-1-(4-t-butylphenyl)methane","1,1-bis(3'-indolyl)-1-(4-t-butylphenyl)methane","C505816","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2008,"18501502","Cancer chemotherapy with indole-3-carbinol, bis(3'-indolyl)methane and synthetic analogs.","18501502",136]
["1,1-bis(3'-indolyl)-1-(4-t-butylphenyl)methane","1,1-bis(3'-indolyl)-1-(4-t-butylphenyl)methane","C505816","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"21129193","1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induce autophagic cell death in estrogen receptor negative breast cancer.","21129193",136]
["1,1-bis(3'-indolyl)-1-(4-t-butylphenyl)methane","1,1-bis(3'-indolyl)-1-(4-t-butylphenyl)methane","C505816","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"21597379","Chemopreventive effects of synthetic C-substituted diindolylmethanes originating from cruciferous vegetables in human oral cancer cells.","21597379",136]
["1,1-bis(3'-indolyl)-1-(4-t-butylphenyl)methane","1,1-bis(3'-indolyl)-1-(4-t-butylphenyl)methane","C505816","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2005,"16155208","1,1-Bis(3'-indolyl)-1-(p-substitutedphenyl)methanes are peroxisome proliferator-activated receptor gamma agonists but decrease HCT-116 colon cancer cell survival through receptor-independent activation of early growth response-1 and nonsteroidal anti-inflammatory drug-activated gene-1.","16155208",136]
["1,1-bis(3'-indolyl)-1-(4-t-butylphenyl)methane","1,1-bis(3'-indolyl)-1-(4-t-butylphenyl)methane","C505816","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2006,"16731770","1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit colon cancer cell and tumor growth through PPARgamma-dependent and PPARgamma-independent pathways.","16731770",136]
["1,1-bis(3'-indolyl)-1-(4-t-butylphenyl)methane","1,1-bis(3'-indolyl)-1-(4-t-butylphenyl)methane","C505816","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2008,"17624585","1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit proliferation of estrogen receptor-negative breast cancer cells by activation of multiple pathways.","17624585",136]
["1,1-bis(3'-indolyl)-1-(4-t-butylphenyl)methane","1,1-bis(3'-indolyl)-1-(4-t-butylphenyl)methane","C505816","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2007,"18006776","1,1-bis(3'-indolyl)-1-(p-substitutedphenyl)methanes induce apoptosis and inhibit renal cell carcinoma growth.","18006776",136]
["1,1-bis(3'-indolyl)-1-(4-t-butylphenyl)methane","1,1-bis(3'-indolyl)-1-(4-t-butylphenyl)methane","C505816","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2008,"18085536","1,1-bis(3'-indolyl)-1-(p-substituted phenyl)methanes decrease mitochondrial membrane potential and induce apoptosis in endometrial and other cancer cell lines.","18085536",136]
["1,1-bis(3'-indolyl)-1-(4-t-butylphenyl)methane","1,1-bis(3'-indolyl)-1-(4-t-butylphenyl)methane","C505816","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"21129193","1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induce autophagic cell death in estrogen receptor negative breast cancer.","21129193",136]
["1,1-bis(3'-indolyl)-1-(4-t-butylphenyl)methane","1,1-bis(3'-indolyl)-1-(4-t-butylphenyl)methane","C505816","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21597379","Chemopreventive effects of synthetic C-substituted diindolylmethanes originating from cruciferous vegetables in human oral cancer cells.","21597379",136]
["1,1-bis(3'-indolyl)-1-(4-t-butylphenyl)methane","1,1-bis(3'-indolyl)-1-(4-t-butylphenyl)methane","C505816","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2010,"21129193","1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induce autophagic cell death in estrogen receptor negative breast cancer.","21129193",136]
["1,1-bis(3'-indolyl)-1-(4-trifluoromethylphenyl)methane","1,1-bis(3'-indolyl)-1-(4-trifluoromethylphenyl)methane","C492909","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2004,"15026545","A new class of peroxisome proliferator-activated receptor gamma (PPARgamma) agonists that inhibit growth of breast cancer cells: 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes.","15026545",136]
["1,1-bis(3'-indolyl)-1-(4-trifluoromethylphenyl)methane","1,1-bis(3'-indolyl)-1-(4-trifluoromethylphenyl)methane","C492909","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2005,"16155208","1,1-Bis(3'-indolyl)-1-(p-substitutedphenyl)methanes are peroxisome proliferator-activated receptor gamma agonists but decrease HCT-116 colon cancer cell survival through receptor-independent activation of early growth response-1 and nonsteroidal anti-inflammatory drug-activated gene-1.","16155208",136]
["1,1-bis(3'-indolyl)-1-(4-trifluoromethylphenyl)methane","1,1-bis(3'-indolyl)-1-(4-trifluoromethylphenyl)methane","C492909","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2008,"18041089","The peroxisome proliferator-activated receptor-gamma agonist 1,1-bis(3'-indolyl)-1-(p-trifluoromethylphenyl)methane suppresses manganese-induced production of nitric oxide in astrocytes and inhibits apoptosis in cocultured PC12 cells.","18041089",136]
["1,1-bis(3'-indolyl)-1-(4-trifluoromethylphenyl)methane","1,1-bis(3'-indolyl)-1-(4-trifluoromethylphenyl)methane","C492909","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2005,"16155208","1,1-Bis(3'-indolyl)-1-(p-substitutedphenyl)methanes are peroxisome proliferator-activated receptor gamma agonists but decrease HCT-116 colon cancer cell survival through receptor-independent activation of early growth response-1 and nonsteroidal anti-inflammatory drug-activated gene-1.","16155208",136]
["1,1-bis(3'-indolyl)-1-(4-trifluoromethylphenyl)methane","1,1-bis(3'-indolyl)-1-(4-trifluoromethylphenyl)methane","C492909","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2006,"16731770","1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit colon cancer cell and tumor growth through PPARgamma-dependent and PPARgamma-independent pathways.","16731770",136]
["1,1-bis(3'-indolyl)-1-(p-anisyl)methane","1,1-bis(3'-indolyl)-1-(p-anisyl)methane","C545255","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2009,"19584258","p21 expression is induced by activation of nuclear nerve growth factor-induced Balpha (Nur77) in pancreatic cancer cells.","19584258",136]
["1,1-bis(3'-indolyl)methane","1,1-bis(3'-indolyl)methane","C512018","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2006,"16051428","Inhibition of breast cancer cell growth and induction of cell death by 1,1-bis(3'-indolyl)methane (DIM) and 5,5'-dibromoDIM.","16051428",136]
["1,1-bis(3'-indolyl)methane","1,1-bis(3'-indolyl)methane","C512018","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2008,"17957723","1,1-bis(3'-indolyl)-1-(p-methoxyphenyl)methane activates Nur77-independent proapoptotic responses in colon cancer cells.","17957723",136]
["1,1-bis(3'-indolyl)methane","1,1-bis(3'-indolyl)methane","C512018","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2006,"16051428","Inhibition of breast cancer cell growth and induction of cell death by 1,1-bis(3'-indolyl)methane (DIM) and 5,5'-dibromoDIM.","16051428",136]
["1,1-bis(3'-indolyl)methane","1,1-bis(3'-indolyl)methane","C512018","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2008,"17957723","1,1-bis(3'-indolyl)-1-(p-methoxyphenyl)methane activates Nur77-independent proapoptotic responses in colon cancer cells.","17957723",136]
["1,1-bis(3'-indolyl)methane","1,1-bis(3'-indolyl)methane","C512018","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"26918831","Anti-cancer drug 3,3'-diindolylmethane activates Wnt4 signaling to enhance gastric cancer cell stemness and tumorigenesis.","26918831",136]
["1,1-bis(3'-indolyl)methane","1,1-bis(3'-indolyl)methane","C512018","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"24619770","Inclusion complexation of phenoxyaliphatic acid derivatives of 3,3'-bis(indolyl)methanes with β-cyclodextrin.","24619770",136]
["1,1-bis(3'-indolyl)methane","1,1-bis(3'-indolyl)methane","C512018","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2006,"16051428","Inhibition of breast cancer cell growth and induction of cell death by 1,1-bis(3'-indolyl)methane (DIM) and 5,5'-dibromoDIM.","16051428",136]
["1,1-bis(4-hydroxyphenyl)-2-phenylbut-1-ene","1,1-bis(4-hydroxyphenyl)-2-phenylbut-1-ene","C052383","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24819221","Differences in the rate of oestrogen-induced apoptosis in breast cancer by oestradiol and the triphenylethylene bisphenol.","24819221",136]
["1,1-bis(4-hydroxyphenyl)-2-phenylbut-1-ene","1,1-bis(4-hydroxyphenyl)-2-phenylbut-1-ene","C052383","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24819221","Differences in the rate of oestrogen-induced apoptosis in breast cancer by oestradiol and the triphenylethylene bisphenol.","24819221",136]
["1,1-bis(4-hydroxyphenyl)cyclohexane","1,1-bis(4-hydroxyphenyl)cyclohexane","C517113","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"17140625","Photodegradation of bisphenol Z by UV irradiation in the presence of beta-cyclodextrin.","17140625",136]
["1,1'-bis-(4-sulfobutyl)indotricarbocyanine-5,5'-dicarboxylic acid diglucamide","1,1'-bis-(4-sulfobutyl)indotricarbocyanine-5,5'-dicarboxylic acid diglucamide","C430879","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2008,"18331624","Differentiation of angiogenic burden in human cancer xenografts using a perfusion-type optical contrast agent (SIDAG).","18331624",136]
["1,1-diamino-2,2-dinitroethene","1,1-diamino-2,2-dinitroethene","C533965","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2009,"19008043","High performance liquid chromatography of 1,1-diamino-2,2-dinitroethene and some intermediate products of its synthesis.","19008043",136]
["1,1-dichloro-1-fluoroethane","1,1-dichloro-1-fluoroethane","C068320","7_AO",872,7,"Site of Contact Nasal Tumors","Increase","Nose","D009666","Nose",1,3,2001,"11684360","Selective inactivation of rat and bovine olfactory cytochrome P450 by three haloethanes.","11684360",136]
["1,1-dichloro-2-(4-methoxyphenyl)-3-phenylcyclopropane","1,1-dichloro-2-(4-methoxyphenyl)-3-phenylcyclopropane","C531316","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2008,"18367102","(Z)-1,1-Dichloro-2-(4-methoxyphenyl)-3-phenylcyclopropane induces concentration-dependent growth inhibition, apoptosis, and coordinates regulation of apoptotic genes in TRAMP cells.","18367102",136]
["1,1-dichloro-2-(4-methoxyphenyl)-3-phenylcyclopropane","1,1-dichloro-2-(4-methoxyphenyl)-3-phenylcyclopropane","C531316","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2008,"18367102","(Z)-1,1-Dichloro-2-(4-methoxyphenyl)-3-phenylcyclopropane induces concentration-dependent growth inhibition, apoptosis, and coordinates regulation of apoptotic genes in TRAMP cells.","18367102",136]
["1,1-dichloro-2,3-diphenyl-2-(4-methoxyphenyl)cyclopropane","1,1-dichloro-2,3-diphenyl-2-(4-methoxyphenyl)cyclopropane","C075421","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2000,"11102952","Z-1,1-Dichloro-2,3-diphenylcyclopropanes block human prostate carcinoma cell proliferation, inhibit prostate-specific antigen expression, and initiate apoptosis.","11102952",136]
["1,1-dichloro-4-ethyl-5-(4-nitrophenyl)hexan-2-one","1,1-dichloro-4-ethyl-5-(4-nitrophenyl)hexan-2-one","C561927","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,1,2011,"21240675","Genome shuffling of marine derived bacterium Nocardia sp. ALAA 2000 for improved ayamycin production.","21240675",136]
["1,1-dichloroacetone","1,1-dichloroacetone","C051717","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,1986,"3816723","Studies of the toxic interactions of disinfection by-products.","3816723",136]
["1,1-dichloroethane","1,1-dichloroethane","C501196","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Atrophy","D001284","Atrophy",1,1,1949,"18143915","Severe adrenal cortical atrophy (cytotoxic) and hepatic damage produced in dogs by feeding 2,2-bis(parachlorophenyl)-1,1-dichloroethane (DDD or TDE).","18143915",136]
["1,1-dichloroethane","1,1-dichloroethane","C501196","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Atrophy","D001284","Atrophy",1,1,1948,"18916907","Adrenal cortical atrophy and liver damage produced in dogs by feeding 2,2-bis-(parachloro-phenyl)-1,1-dichloroethane.","18916907",136]
["1,1-dichloropropene","1,1-dichloropropene","C500392","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2005,"15790493","Genotoxicity and metabolism of the source-water contaminant 1,1-dichloropropene: activation by GSTT1-1 and structure-activity considerations.","15790493",136]
["1,1-dichloropropene","1,1-dichloropropene","C500392","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,2,2006,"16337249","Sub-chronic exposure to 1,1-dichloropropene induces frameshift mutations in lambda transgenic medaka.","16337249",136]
["1,1-dicyano-2-(4,5-dimethoxy-2-nitrophenyl)ethene","1,1-dicyano-2-(4,5-dimethoxy-2-nitrophenyl)ethene","C417196","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2000,"10945435","Inhibition of Papaya latex papain by photosensitive inhibitors. 1-(4,5-dimethoxy-2-nitrophenyl)-2-nitroethene and 1,1-dicyano-2-(4,5-dimethoxy-2-nitrophenyl)-ethene.","10945435",136]
["1,1-dicyano-2-(4,5-dimethoxy-2-nitrophenyl)ethene","1,1-dicyano-2-(4,5-dimethoxy-2-nitrophenyl)ethene","C417196","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2000,"10945436","Photoreversible modulators of Escherichia coli beta-galactosidase. 1-Benzoyl-1-cyano-2-(4,5-dimethoxy-2-nitrophenyl)-ethene and 1,1-dicyano-2-(4,5-dimethoxy-2-nitrophenyl)-ethene.","10945436",136]
["1,1-diethyl-2-hydroxy-2-nitrosohydrazine","1,1-diethyl-2-hydroxy-2-nitrosohydrazine","C084012","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,1996,"8615678","Nitric oxide (NO) in apoptotic versus necrotic RAW 264.7 macrophage cell death: the role of NO-donor exposure, NAD+ content, and p53 accumulation.","8615678",136]
["1,1-diethyl-2-hydroxy-2-nitrosohydrazine","1,1-diethyl-2-hydroxy-2-nitrosohydrazine","C084012","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,1996,"8615678","Nitric oxide (NO) in apoptotic versus necrotic RAW 264.7 macrophage cell death: the role of NO-donor exposure, NAD+ content, and p53 accumulation.","8615678",136]
["1,1-difluoro-1-trimethylsilanyl methylphosphonic acid","1,1-difluoro-1-trimethylsilanyl methylphosphonic acid","C522995","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2006,"16984154","DFTMP, an NMR reagent for assessing the near-neutral pH of biological samples.","16984154",136]
["1,1-difluoro-3-hexadecanamido-2-(5-hydroxypentyl)-4-phenylbutanephosphonic acid","1,1-difluoro-3-hexadecanamido-2-(5-hydroxypentyl)-4-phenylbutanephosphonic acid","C473787","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2003,"12672022","Elevation of de novo ceramide synthesis in tumor masses and the role of microsomal dihydroceramide synthase.","12672022",136]
["1,1-difluoroethylene","1,1-difluoroethylene","C007384","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24857462","Ferroelectric polymer scaffolds based on a copolymer of tetrafluoroethylene with vinylidene fluoride: fabrication and properties.","24857462",136]
["1,1-dimethyl-2-(2-(quinolin-4-yl)vinyl)-1H-benzo(e)indole","1,1-dimethyl-2-(2-(quinolin-4-yl)vinyl)-1H-benzo(e)indole","C000601531","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2015,"25664606","Ratiometric emission fluorescent pH probe for imaging of living cells in extreme acidity.","25664606",136]
["1,1-dimethyl-2-(2-(quinolin-4-yl)vinyl)-1H-benzo(e)indole","1,1-dimethyl-2-(2-(quinolin-4-yl)vinyl)-1H-benzo(e)indole","C000601531","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2015,"25664606","Ratiometric emission fluorescent pH probe for imaging of living cells in extreme acidity.","25664606",136]
["1,1-dimethyl-4-acetylpiperazinium","1,1-dimethyl-4-acetylpiperazinium","C080419","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2013,"24038948","HPIP is upregulated in liver cancer and promotes hepatoma cell proliferation via activation of G2/M transition.","24038948",136]
["1,1-dimethyl-5-(1-hydroxypropyl)-4,6,7-trimethylindan","1,1-dimethyl-5-(1-hydroxypropyl)-4,6,7-trimethylindan","C107655","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1997,"9256247","A novel compound, 1,1-dimethyl-5(1-hydroxypropyl)-4,6,7-trimethylindan, is an effective inhibitor of the tet(K) gene-encoded metal-tetracycline/H+ antiporter of Staphylococcus aureus.","9256247",136]
["1,1-dimethylbutyl-1-deoxy-Delta(9)-THC","1,1-dimethylbutyl-1-deoxy-Delta(9)-THC","C432747","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2001,"11479216","Inhibition of glioma growth in vivo by selective activation of the CB(2) cannabinoid receptor.","11479216",136]
["1,1-dimethylbutyl-1-deoxy-Delta(9)-THC","1,1-dimethylbutyl-1-deoxy-Delta(9)-THC","C432747","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2009,"19887554","Synthetic cannabinoid receptor agonists inhibit tumor growth and metastasis of breast cancer.","19887554",136]
["1,1-dimethylbutyl-1-deoxy-Delta(9)-THC","1,1-dimethylbutyl-1-deoxy-Delta(9)-THC","C432747","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22119709","Cannabinoid receptor-2 (CB2) agonist ameliorates colitis in IL-10(-/-) mice by attenuating the activation of T cells and promoting their apoptosis.","22119709",136]
["1,1-dimethylbutyl-1-deoxy-Delta(9)-THC","1,1-dimethylbutyl-1-deoxy-Delta(9)-THC","C432747","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2013,"23139224","Activation of cannabinoid receptor 2 reduces inflammation in acute experimental pancreatitis via intra-acinar activation of p38 and MK2-dependent mechanisms.","23139224",136]
["1,1-dimethylbutyl-1-deoxy-Delta(9)-THC","1,1-dimethylbutyl-1-deoxy-Delta(9)-THC","C432747","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23711495","Activation of cannabinoid type 2 receptor by JWH133 protects heart against ischemia/reperfusion-induced apoptosis.","23711495",136]
["1,1-dimethylbutyl-1-deoxy-Delta(9)-THC","1,1-dimethylbutyl-1-deoxy-Delta(9)-THC","C432747","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"25058046","Cannabinoid receptor type 2 agonist attenuates apoptosis by activation of phosphorylated CREB-Bcl-2 pathway after subarachnoid hemorrhage in rats.","25058046",136]
["1,1-dimethylbutyl-1-deoxy-Delta(9)-THC","1,1-dimethylbutyl-1-deoxy-Delta(9)-THC","C432747","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2007,"17537989","Anti-inflammatory property of the cannabinoid receptor-2-selective agonist JWH-133 in a rodent model of autoimmune uveoretinitis.","17537989",136]
["1,1-dimethylbutyl-1-deoxy-Delta(9)-THC","1,1-dimethylbutyl-1-deoxy-Delta(9)-THC","C432747","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"19442435","Cannabinoids in the treatment of cancer.","19442435",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C1539,B1539)","v":"1,1-dimethylbutyl-1-deoxy-Delta(9)-THC"},"1,1-dimethylbutyl-1-deoxy-Delta(9)-THC","C432747","3_KE",870,3,"Cell Proliferation","Increase",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J1539,K1539)","v":"Cell Proliferation"},"D049109","Cell Proliferation",1,1,2012,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q1539,Q1539)","v":"22578958"},"Anti-proliferative and anti-angiogenic effects of CB2R agonist (JWH-133) in non-small lung cancer cells (A549) and human umbilical vein endothelial cells: an in vitro investigation.","22578958",136]
["1,1-dimethylbutyl-1-deoxy-Delta(9)-THC","1,1-dimethylbutyl-1-deoxy-Delta(9)-THC","C432747","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"22978792","Evaluation of anti-invasion effect of cannabinoids on human hepatocarcinoma cells.","22978792",136]
["1,1-dimethylbutyl-1-deoxy-Delta(9)-THC","1,1-dimethylbutyl-1-deoxy-Delta(9)-THC","C432747","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2003,"12514108","Inhibition of tumor angiogenesis by cannabinoids.","12514108",136]
["1,1-dimethylbutyl-1-deoxy-Delta(9)-THC","1,1-dimethylbutyl-1-deoxy-Delta(9)-THC","C432747","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2009,"19887554","Synthetic cannabinoid receptor agonists inhibit tumor growth and metastasis of breast cancer.","19887554",136]
["1,1-dimethylbutyl-1-deoxy-Delta(9)-THC","1,1-dimethylbutyl-1-deoxy-Delta(9)-THC","C432747","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2012,"22578958","Anti-proliferative and anti-angiogenic effects of CB2R agonist (JWH-133) in non-small lung cancer cells (A549) and human umbilical vein endothelial cells: an in vitro investigation.","22578958",136]
["1,1'-dimethylferrocene","1,1'-dimethylferrocene","C050099","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1996,"9100358","An improved enzymatic assay for glucose determination in blood serum using a 1,1'-dimethylferricinium dye.","9100358",136]
["1',1'-dimethylheptyl-delta(8)-tetrahydrocannabinol-11-oic acid","1',1'-dimethylheptyl-delta(8)-tetrahydrocannabinol-11-oic acid","C113759","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2004,"15472543","Application of a new collagen-based sealant for the treatment of pancreatic injury.","15472543",136]
["1,1-dimethylurea","1,1-dimethylurea","C018275","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1994,"7945795","Denaturation behavior of alpha-chymotrypsinogen A in urea and alkylurea solutions: fluorescence studies.","7945795",136]
["1,1-dimethylurea","1,1-dimethylurea","C018275","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,1,1992,"1377783","Mutagenicity of N,N'-dimethylurea and methylamine hydrochloride in the Ames Salmonella/microsome test: absence of mutagenic response.","1377783",136]
["1,1-diphenyl-2-picrylhydrazyl","1,1-diphenyl-2-picrylhydrazyl","C004931","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27325381","Facile One-Pot Synthesis of Tellurium Nanorods as Antioxidant and Anticancer Agents.","27325381",136]
["1,1-diphenyl-2-picrylhydrazyl","1,1-diphenyl-2-picrylhydrazyl","C004931","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,1997,"9466953","Peroxynitrite-induced apoptosis in epithelial (T84) and macrophage (RAW 264.7) cell lines: effect of legume-derived polyphenols (phytolens).","9466953",136]
["1,1-diphenyl-2-picrylhydrazyl","1,1-diphenyl-2-picrylhydrazyl","C004931","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22410248","Free radical scavenging and antiproliferative properties of Biginelli adducts.","22410248",136]
["1,1-diphenyl-2-picrylhydrazyl","1,1-diphenyl-2-picrylhydrazyl","C004931","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"23738950","New spiroindolinones bearing 5-chlorobenzothiazole moiety.","23738950",136]
["1,1-diphenyl-2-picrylhydrazyl","1,1-diphenyl-2-picrylhydrazyl","C004931","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27325381","Facile One-Pot Synthesis of Tellurium Nanorods as Antioxidant and Anticancer Agents.","27325381",136]
["1,1-diphenyl-2-picrylhydrazyl","1,1-diphenyl-2-picrylhydrazyl","C004931","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28482262","Facile synthesis of fluoro, methoxy, and methyl substituted ferrocene-based urea complexes as potential therapeutic agents.","28482262",136]
["1,1-diphenyl-2-picrylhydrazyl","1,1-diphenyl-2-picrylhydrazyl","C004931","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1999,"10375392","Oxidative modification of apolipoprotein E in human very-low-density lipoprotein and its inhibition by glycosaminoglycans.","10375392",136]
["1,1-diphenyl-2-picrylhydrazyl","1,1-diphenyl-2-picrylhydrazyl","C004931","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1999,"10628336","Radical intensity and cytotoxicity of butylated hydroxyanisole and its orthobisphenol dimer.","10628336",136]
["1,1-diphenyl-2-picrylhydrazyl","1,1-diphenyl-2-picrylhydrazyl","C004931","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1999,"11233150","Free radical scavenging activity in the nonenzymatic fraction of human saliva: a simple DPPH assay showing the effect of physical exercise.","11233150",136]
["1,1-diphenyl-2-picrylhydrazyl","1,1-diphenyl-2-picrylhydrazyl","C004931","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2001,"11304937","Effect of nilvadipine in weak acidic medium by 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay.","11304937",136]
["1,1-diphenyl-2-picrylhydrazyl","1,1-diphenyl-2-picrylhydrazyl","C004931","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2001,"11600050","Antioxidant activities of dioscorin, the storage protein of yam (Dioscorea batatas Decne) tuber.","11600050",136]
["1,1-diphenyl-2-picrylhydrazyl","1,1-diphenyl-2-picrylhydrazyl","C004931","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2006,"16763687","Kinetics of the reaction between the antioxidant Trolox and the free radical DPPH in semi-aqueous solution.","16763687",136]
["1,1-diphenyl-2-picrylhydrazyl","1,1-diphenyl-2-picrylhydrazyl","C004931","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"17210454","Improving the in vivo predictability of an on-line HPLC stable free radical decoloration assay for antioxidant activity in methanol-buffer medium.","17210454",136]
["1,1-diphenyl-2-picrylhydrazyl","1,1-diphenyl-2-picrylhydrazyl","C004931","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2010,"20708120","High-performance liquid chromatography with post-column 2,2'-diphenyl-1-picrylhydrazyl radical scavenging assay: methodological considerations and application to complex samples.","20708120",136]
["1,1-diphenyl-2-picrylhydrazyl","1,1-diphenyl-2-picrylhydrazyl","C004931","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2011,"21897036","Production of starch with antioxidative activity by baking starch with organic acids.","21897036",136]
["1,1-diphenyl-2-picrylhydrazyl","1,1-diphenyl-2-picrylhydrazyl","C004931","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"22953869","Temperature-dependent stability and DPPH scavenging activity of liposomal curcumin at pH 7.0.","22953869",136]
["1,1-diphenyl-2-picrylhydrazyl","1,1-diphenyl-2-picrylhydrazyl","C004931","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"25181475","The activity-integrated method for quality assessment of reduning injection by on-line DPPH-CE-DAD.","25181475",136]
["1,1-diphenyl-2-picrylhydrazyl","1,1-diphenyl-2-picrylhydrazyl","C004931","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2015,"25578761","Effect of pH and metal ions on DPPH radical scavenging activity of tea.","25578761",136]
["1,1-diphenyl-2-picrylhydrazyl","1,1-diphenyl-2-picrylhydrazyl","C004931","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1988,"3128297","Interaction of flavonoids with 1,1-diphenyl-2-picrylhydrazyl free radical, liposomal membranes and soybean lipoxygenase-1.","3128297",136]
["1,1-diphenyl-2-picrylhydrazyl","1,1-diphenyl-2-picrylhydrazyl","C004931","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1993,"8250955","Hydroxyl radical damage to DNA sugar and model membranes induced by anthralin (dithranol).","8250955",136]
["1,1-diphenyl-2-picrylhydrazyl","1,1-diphenyl-2-picrylhydrazyl","C004931","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1996,"8902534","Scavenging effects of tea catechins and their derivatives on 1,1-diphenyl-2-picrylhydrazyl radical.","8902534",136]
["1,1-diphenyl-2-picrylhydrazyl","1,1-diphenyl-2-picrylhydrazyl","C004931","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1997,"9075196","Synthesis of a novel vitamin E derivative, 2-(alpha-D-glucopyranosyl) methyl-2,5,7,8-tetramethylchroman-6-ol, by alpha-glucosidase-catalyzed transglycosylation.","9075196",136]
["1,1-diphenyl-2-picrylhydrazyl","1,1-diphenyl-2-picrylhydrazyl","C004931","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1998,"9838217","Oxidation of the flavonol fisetin by polyphenol oxidase.","9838217",136]
["1,1-diphenyl-2-picrylhydrazyl","1,1-diphenyl-2-picrylhydrazyl","C004931","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1999,"9878710","Potent antiperoxidation activity of the bisbenzylisoquinoline alkaloid cepharanthine: the amine moiety is responsible for its pH-dependent radical scavenge activity.","9878710",136]
["1,1-diphenylethene","1,1-diphenylethene","C587461","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2015,"25621421","Electron transfer-induced coupling of haloarenes to styrenes and 1,1-diphenylethenes triggered by diketopiperazines and Potassium tert-butoxide.","25621421",136]
["1,1'-disulfobutyl-3,3,3',3'-tetramethylindotricarbocyanine","1,1'-disulfobutyl-3,3,3',3'-tetramethylindotricarbocyanine","C479728","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2005,"15911398","Spectrophotometric determination of DNA using a near infrared probe 1,1'-disulfobutyl-3,3,3',3'-tetramethylindotricarbocyanine.","15911398",136]
["1,1-ethanediol","1,1-ethanediol","C041868","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1984,"6430146","Isotope and pH effects on the dehydration of acetaldehyde hydrate by carbonic anhydrase.","6430146",136]
["1,1'-oxalyldiimidazole","1,1'-oxalyldiimidazole","C554599","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2013,"24148468","Role of background observed in aptasensor with chemiluminescence detection.","24148468",136]
["1,2(4)-topaminequinone","1,2(4)-topaminequinone","C083552","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1993,"8405659","Oxidation of 6-hydroxydopamine catalyzed by tyrosinase.","8405659",136]
["1,2-(palmitoyl-NBD-aminocaproyl)phosphatidylethanolamine","1,2-(palmitoyl-NBD-aminocaproyl)phosphatidylethanolamine","C052267","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1996,"8634315","Rapid transmembrane movement of C6-NBD-labeled phospholipids across the inner membrane of Escherichia coli.","8634315",136]
["1,2,2,4,5,5,-hexamethyl-3-imidazolidine oxide","1,2,2,4,5,5,-hexamethyl-3-imidazolidine oxide","C079221","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2003,"12594760","In vivo detection of a pH-sensitive nitroxide in the rat stomach by low-field ESR-based techniques.","12594760",136]
["1,2,2,4,5,5,-hexamethyl-3-imidazolidine oxide","1,2,2,4,5,5,-hexamethyl-3-imidazolidine oxide","C079221","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2006,"16798033","Real-time monitoring of drug-induced changes in the stomach acidity of living rats using improved pH-sensitive nitroxides and low-field EPR techniques.","16798033",136]
["1,2,3,4,6,7,8-heptachlorodibenzodioxin","1,2,3,4,6,7,8-heptachlorodibenzodioxin","C046839","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,1996,"8658510","Quantitative analysis of enzyme-altered liver foci in rats initiated with diethylnitrosamine and promoted with 2,3,7,8-tetrachlorodibenzo-p-dioxin or 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin.","8658510",136]
["1,2,3,4,6,7-hexachlorinated naphthalene","1,2,3,4,6,7-hexachlorinated naphthalene","C412791","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Atrophy","D001284","Atrophy",1,1,2012,"22813907","Repeated dose toxicity and relative potency of 1,2,3,4,6,7-hexachloronaphthalene (PCN 66) 1,2,3,5,6,7-hexachloronaphthalene (PCN 67) compared to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) for induction of CYP1A1, CYP1A2 and thymic atrophy in female Harlan Sprague-Dawley rats.","22813907",136]
["1,2,3,4,6-penta-O-galloylglucopyranoside","1,2,3,4,6-penta-O-galloylglucopyranoside","C000615595","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27153064","Identification of 1,2,3,4,6-Penta-O-galloyl-β-d-glucopyranoside as a Glycine N-Methyltransferase Enhancer by High-Throughput Screening of Natural Products Inhibits Hepatocellular Carcinoma.","27153064",136]
["1,2,3,4-tetrahydro-1-(phenylmethyl)isoquinoline","1,2,3,4-tetrahydro-1-(phenylmethyl)isoquinoline","C084924","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2003,"12782106","1-Benzyl-1,2,3,4-tetrahydroisoquinoline (1BnTIQ), an endogenous neurotoxin, induces dopaminergic cell death through apoptosis.","12782106",136]
["1,2,3,4-tetrahydro-1-(phenylmethyl)isoquinoline","1,2,3,4-tetrahydro-1-(phenylmethyl)isoquinoline","C084924","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24190811","Concentration-dependent opposite effects of 1-benzyl-1,2,3,4-tetrahydroisoquinoline on markers of apoptosis: in vitro and ex vivo studies.","24190811",136]
["1,2,3,4-tetrahydro-1-(phenylmethyl)isoquinoline","1,2,3,4-tetrahydro-1-(phenylmethyl)isoquinoline","C084924","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,1998,"9922818","Endogenous dopamine-derived neurotoxins and Parkinson's disease.","9922818",136]
["1,2,3,4-tetrahydro-1-phenylisoquinoline","1,2,3,4-tetrahydro-1-phenylisoquinoline","C096775","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2006,"16412536","Synthesis and in vitro cytotoxicity of 1,2,3,4-tetrahydroisoquinoline derivatives.","16412536",136]
["1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid","1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid","C054910","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"23275050","(3S)-1,2,3,4-Tetrahydro-β-carboline-3-carboxylic acid from Cichorium endivia. L induces apoptosis of human colorectal cancer HCT-8 cells.","23275050",136]
["1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid","1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid","C054910","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"23275050","(3S)-1,2,3,4-Tetrahydro-β-carboline-3-carboxylic acid from Cichorium endivia. L induces apoptosis of human colorectal cancer HCT-8 cells.","23275050",136]
["1,2,3,4-tetrahydroisoquinoline","1,2,3,4-tetrahydroisoquinoline","C014843","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2009,"19217289","Atropisomeric small molecule Bcl-2 ligands: determination of bioactive conformation.","19217289",136]
["1,2,3,4-tetrahydroisoquinoline","1,2,3,4-tetrahydroisoquinoline","C014843","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2009,"19481842","Facile synthesis and in vitro properties of 1-alkyl- and 1-alkyl-N-propargyl-1,2,3,4-tetrahydroisoquinoline derivatives on PC12 cells.","19481842",136]
["1,2,3,4-tetrahydroisoquinoline","1,2,3,4-tetrahydroisoquinoline","C014843","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2009,"19661319","Tumor-specific cytotoxic activity of 1,2,3,4-tetrahydroisoquinoline derivatives against human oral squamous cell carcinoma cell lines.","19661319",136]
["1,2,3,4-tetrahydroisoquinoline","1,2,3,4-tetrahydroisoquinoline","C014843","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"25071204","The role of PI3K/AKT-related PIP5K1α and the discovery of its selective inhibitor for treatment of advanced prostate cancer.","25071204",136]
["1,2,3,4-tetrahydroisoquinoline","1,2,3,4-tetrahydroisoquinoline","C014843","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2018,"29573707","A novel tetrahydroisoquinoline (THIQ) analogue induces mitochondria-dependent apoptosis.","29573707",136]
["1,2,3,4-tetrahydroisoquinoline","1,2,3,4-tetrahydroisoquinoline","C014843","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"25071204","The role of PI3K/AKT-related PIP5K1α and the discovery of its selective inhibitor for treatment of advanced prostate cancer.","25071204",136]
["1,2,3,4-tetrahydroisoquinoline","1,2,3,4-tetrahydroisoquinoline","C014843","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"26287146","Synthesis of C3/C1-Substituted Tetrahydroisoquinolines.","26287146",136]
["1,2,3,4-tetrahydroisoquinoline","1,2,3,4-tetrahydroisoquinoline","C014843","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27232526","Tetrahydroisoquinoline-Derived Urea and 2,5-Diketopiperazine Derivatives as Selective Antagonists of the Transient Receptor Potential Melastatin 8 (TRPM8) Channel Receptor and Antiprostate Cancer Agents.","27232526",136]
["1,2,3,4-tetrahydroisoquinoline","1,2,3,4-tetrahydroisoquinoline","C014843","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"29438891","Synthesis and pharmacological evaluation of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives as sigma-2 receptor ligands.","29438891",136]
["1,2,3,4-tetrahydroisoquinoline","1,2,3,4-tetrahydroisoquinoline","C014843","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2018,"29573707","A novel tetrahydroisoquinoline (THIQ) analogue induces mitochondria-dependent apoptosis.","29573707",136]
["1,2,3,4-tetrahydroisoquinoline","1,2,3,4-tetrahydroisoquinoline","C014843","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2018,"29656198","Synthesis and biological evaluation of 2,5-disubstituted furan derivatives as P-glycoprotein inhibitors for Doxorubicin resistance in MCF-7/ADR cell.","29656198",136]
["1,2,3,4-tetrahydroisoquinoline","1,2,3,4-tetrahydroisoquinoline","C014843","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1988,"2963591","Substrate specificity of nicotinamide methyltransferase isolated from porcine liver.","2963591",136]
["1,2,3,4-tetrahydroisoquinoline carboxylic acid","1,2,3,4-tetrahydroisoquinoline carboxylic acid","C031270","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2005,"15842750","Capillary electrophoresis for diastereomers of (R,S)-tetrahydroisoquinoline-3-carboxylic acid derivatized with (R)-4-nitro-7-(3-aminopyrrolidin-1-yl)-2,1,3-benzoxadiazole: effect of molecular geometries.","15842750",136]
["1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid","1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid","C078986","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"22248818","pH-Dependent nanostructure based on isoquinoline-cyclodextrin conjugate for thrombosis therapy.","22248818",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C1603,B1603)","v":"1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid"},"1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid","C078986","1_MIE",867,1,"Intracellular pH","Decrease",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J1603,K1603)","v":"Hydrogen-Ion Concentration"},"D006863","Hydrogen-Ion Concentration",2,2,1995,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q1603,Q1603)","v":"7558588"},"Acid catalysis in the formation of dioxopiperazines from peptides containing tetrahydroisoquinoline-3-carboxylic acid at position 2.","7558588",136]
["1,2,3,4-tetrahydroquinoline","1,2,3,4-tetrahydroquinoline","C542964","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"25214764","Combining structure-based pharmacophore modeling, virtual screening, and in silico ADMET analysis to discover novel tetrahydro-quinoline based pyruvate kinase isozyme M2 activators with antitumor activity.","25214764",136]
["1,2,3,4-tetrahydroquinoline","1,2,3,4-tetrahydroquinoline","C542964","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"26207511","Synthesis and in vitro evaluation of 4-substituted furano[3,2-c] tetrahydroquinolines as potential anti-cancer agents.","26207511",136]
["1,2,3,4-tetrahydroquinoline","1,2,3,4-tetrahydroquinoline","C542964","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20149941","Discovering some novel tetrahydroquinoline derivatives bearing the biologically active sulfonamide moiety as a new class of antitumor agents.","20149941",136]
["1,2,3,4-tetrahydroquinoline","1,2,3,4-tetrahydroquinoline","C542964","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23867604","N-aryl-6-methoxy-1,2,3,4-tetrahydroquinolines: a novel class of antitumor agents targeting the colchicine site on tubulin.","23867604",136]
["1,2,3,4-tetrahydroquinoline","1,2,3,4-tetrahydroquinoline","C542964","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"25214764","Combining structure-based pharmacophore modeling, virtual screening, and in silico ADMET analysis to discover novel tetrahydro-quinoline based pyruvate kinase isozyme M2 activators with antitumor activity.","25214764",136]
["1,2,3,4-tetrahydroquinoline","1,2,3,4-tetrahydroquinoline","C542964","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"26242242","Optimization of N-aryl-6-methoxy-1,2,3,4-tetrahydroquinolines as tubulin polymerization inhibitors.","26242242",136]
["1,2,3,4-tetrahydroquinoline","1,2,3,4-tetrahydroquinoline","C542964","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2018,"29501943","Novel topoisomerase I inhibitors. Syntheses and biological evaluation of phosphorus substituted quinoline derivates with antiproliferative activity.","29501943",136]
["1,2,3,4-tetrahydroquinoline","1,2,3,4-tetrahydroquinoline","C542964","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2011,"21837649","Ocular hypotensive action of a novel tetrahydroquinoline analog in rabbit: physicochemical evaluation.","21837649",136]
["1,2,3,4-tetrahydroquinoline","1,2,3,4-tetrahydroquinoline","C542964","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"24797950","Fragmentation reactions of N-benzyltetrahydroquinolines in electrospray ionization mass spectrometry: the roles of ion/neutral complex intermediates.","24797950",136]
["1,2,3,5,6,7-hexachloronaphthalene","1,2,3,5,6,7-hexachloronaphthalene","C575652","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Atrophy","D001284","Atrophy",1,1,2012,"22813907","Repeated dose toxicity and relative potency of 1,2,3,4,6,7-hexachloronaphthalene (PCN 66) 1,2,3,5,6,7-hexachloronaphthalene (PCN 67) compared to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) for induction of CYP1A1, CYP1A2 and thymic atrophy in female Harlan Sprague-Dawley rats.","22813907",136]
["1,2,3,5,6,7-hexahydroquinoxaline","1,2,3,5,6,7-hexahydroquinoxaline","C539014","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,1,2009,"19182373","Oxidative stress induced by a dihydropyrazine derivative.","19182373",136]
["1,2,3,6-tetragalloylglucose","1,2,3,6-tetragalloylglucose","C060475","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1989,"2757399","Biosynthesis of gallotannins: beta-glucogallin-dependent formation of 1,2,3,4,6-pentagalloylglucose by enzymatic galloylation of 1,2,3,6-tetragalloylglucose.","2757399",136]
["1,2,3,7,8-pentachlorodibenzo-p-dioxin","1,2,3,7,8-pentachlorodibenzo-p-dioxin","C051452","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2011,"21458559","Development of a co-culture model for in vitro toxicological studies in Atlantic salmon.","21458559",136]
["1,2,3,7,8-pentachlorodibenzo-p-dioxin","1,2,3,7,8-pentachlorodibenzo-p-dioxin","C051452","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2006,"16929009","In utero exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin induces amphiregulin gene expression in the developing mouse ureter.","16929009",136]
["1,2,3,9-tetrahydro-4H-carbazol-4-one","1,2,3,9-tetrahydro-4H-carbazol-4-one","C513019","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2009,"19386536","Determination by ultraviolet absorption spectrometry and theoretical calculation of dissociation constant of 1,2,3,9-tetrahydro-4H-carbazol-4-one.","19386536",136]
["1,2,3-trichloropropane","1,2,3-trichloropropane","C009536","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"26763396","Disruption of spindle checkpoint function in rats following 28 days of repeated administration of renal carcinogens.","26763396",136]
["1,2,3-trichloropropane","1,2,3-trichloropropane","C009536","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2011,"21486040","Effects of solution chemistry on the dechlorination of 1,2,3-trichloropropane by zero-valent zinc.","21486040",136]
["1,2,3-trichloropropane","1,2,3-trichloropropane","C009536","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,1,2002,"12089046","Biodegradation of 1,2,3-trichloropropane through directed evolution and heterologous expression of a haloalkane dehalogenase gene.","12089046",136]
["1,2,3-trichloropropane","1,2,3-trichloropropane","C009536","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,1,2014,"24531456","Crystallographic analysis of 1,2,3-trichloropropane biodegradation by the haloalkane dehalogenase DhaA31.","24531456",136]
["1,2,3-trichloropropane","1,2,3-trichloropropane","C009536","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,1991,"1918791","Cardiopathic effect of 1,2,3-trichloropropane after subacute and subchronic exposure in rats.","1918791",136]
["1,2,4,5-benzenetetraamine","1,2,4,5-benzenetetraamine","C539551","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2008,"18989950","A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the y397 site of focal adhesion kinase decreases tumor growth.","18989950",136]
["1,2,4,5-benzenetetraamine","1,2,4,5-benzenetetraamine","C539551","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2009,"19571674","A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer.","19571674",136]
["1,2,4,5-benzenetetraamine","1,2,4,5-benzenetetraamine","C539551","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2008,"18989950","A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the y397 site of focal adhesion kinase decreases tumor growth.","18989950",136]
["1,2,4,5-benzenetetraamine","1,2,4,5-benzenetetraamine","C539551","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"19571674","A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer.","19571674",136]
["1,2,4,5-tetrabromobenzene","1,2,4,5-tetrabromobenzene","C110818","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,1998,"9456081","Hepatotoxicity of brominated benzenes: relationship between chemical structure and hepatotoxic effects in acute intoxication of mice.","9456081",136]
["1,2,4-butanetriol","1,2,4-butanetriol","C000610906","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2016,"26498325","Synthetic pathway optimization for improved 1,2,4-butanetriol production.","26498325",136]
["1,2,4-triazine","1,2,4-triazine","C093444","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2008,"17868955","Synthesis, structure elucidation and identification of antitumoural properties of novel fused 1,2,4-triazine aryl derivatives.","17868955",136]
["1,2,4-triazine","1,2,4-triazine","C093444","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"20946929","Inhibition of LPS-induced apoptosis in differentiated-PC12 cells by new triazine derivatives through NF-κB-mediated suppression of COX-2.","20946929",136]
["1,2,4-triazine","1,2,4-triazine","C093444","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"20376563","Attenuation of NF-kappaB and activation of Nrf2 signaling by 1,2,4-triazine derivatives, protects neuron-like PC12 cells against apoptosis.","20376563",136]
["1,2,4-triazine","1,2,4-triazine","C093444","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"25438754","In vitro antitumor activity evaluation of some 1,2,4-triazine derivatives bearing piperazine amide moiety against breast cancer cells.","25438754",136]
["1,2,4-triazine","1,2,4-triazine","C093444","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28763643","Discovery of 5,6-diaryl-1,2,4-triazines hybrids as potential apoptosis inducers.","28763643",136]
["1,2,4-triazine","1,2,4-triazine","C093444","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28284808","Synthesis of novel 1,2,4-triazine scaffold as FAK inhibitors with antitumor activity.","28284808",136]
["1,2,4-triazine","1,2,4-triazine","C093444","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28763643","Discovery of 5,6-diaryl-1,2,4-triazines hybrids as potential apoptosis inducers.","28763643",136]
["1,2,4-triazole","1,2,4-triazole","C045575","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"22060552","In-vitro cytotoxicity and cell cycle analysis of two novel bis-1,2, 4-triazole derivatives: 1,4-bis[5-(5-mercapto-1,3,4-oxadiazol-2-yl-methyl)-thio-4-(p-tolyl)-1,2,4-triazol-3-yl]-butane (MNP-14) and 1,4-bis[5-(carbethoxy-methyl)-thio-4-(p-ethoxy phenyl)-1,2,4-triazol-3-yl]-butane (MNP-16).","22060552",136]
["1,2,4-triazole","1,2,4-triazole","C045575","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22647723","Synthesis and cytotoxicity of 3,4-disubstituted-5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazoles and novel 5,6-dihydro-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives bearing 3,4,5-trimethoxyphenyl moiety.","22647723",136]
["1,2,4-triazole","1,2,4-triazole","C045575","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"25240098","Novel nitro(triazole/imidazole)-based heteroarylamides/sulfonamides as potential antitrypanosomal agents.","25240098",136]
["1,2,4-triazole","1,2,4-triazole","C045575","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"26638042","Discovery of novel hybrids of diaryl-1,2,4-triazoles and caffeic acid as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase for cancer therapy.","26638042",136]
["1,2,4-triazole","1,2,4-triazole","C045575","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2018,"29660690","New 1,2,4-triazole-Chalcone hybrids induce Caspase-3 dependent apoptosis in A549 human lung adenocarcinoma cells.","29660690",136]
["1,2,4-triazole","1,2,4-triazole","C045575","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"19482385","Synthesis, structure elucidation and antitumour activity of N-substituted amides of 3-(3-ethylthio-1,2,4-triazol-5-yl)propenoic acid.","19482385",136]
["1,2,4-triazole","1,2,4-triazole","C045575","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"19560842","Synthesis of substituted-phenyl-1,2,4-triazol-3-thione analogues with modified D-glucopyranosyl residues and their antiproliferative activities.","19560842",136]
["1,2,4-triazole","1,2,4-triazole","C045575","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21802949","Synthesis and antiproliferative evaluation of 3,5-disubstituted 1,2,4-triazoles containing flurophenyl and trifluoromethanephenyl moieties.","21802949",136]
["1,2,4-triazole","1,2,4-triazole","C045575","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22074986","1,2,4-Triazole D-ribose derivatives: design, synthesis and antitumoral evaluation.","22074986",136]
["1,2,4-triazole","1,2,4-triazole","C045575","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23715503","Synthesis and antiproliferative assay of 1,3,4-oxadiazole and 1,2,4-triazole derivatives in cancer cells.","23715503",136]
["1,2,4-triazole","1,2,4-triazole","C045575","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24506202","Synthesis, antiproliferative and antimicrobial activity of new Mannich bases bearing 1,2,4-triazole moiety.","24506202",136]
["1,2,4-triazole","1,2,4-triazole","C045575","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24308998","1,2,4-Triazole/oxime hybrids as new strategy for nitric oxide donors: Synthesis, anti-inflammatory, ulceroginicity and antiproliferative activities.","24308998",136]
["1,2,4-triazole","1,2,4-triazole","C045575","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"26286663","Recent Developments on 1,2,4-Triazole Nucleus in Anticancer Compounds: A Review.","26286663",136]
["1,2,4-triazole","1,2,4-triazole","C045575","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"26638042","Discovery of novel hybrids of diaryl-1,2,4-triazoles and caffeic acid as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase for cancer therapy.","26638042",136]
["1,2,4-triazole","1,2,4-triazole","C045575","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"26786698","Synthesis and antiproliferative evaluation of novel 1,2,4-triazole derivatives incorporating benzisoselenazolone scaffold.","26786698",136]
["1,2,4-triazole","1,2,4-triazole","C045575","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27287368","Design, synthesis and biological evaluation of novel 3-alkylsulfanyl-4-amino-1,2,4-triazole derivatives.","27287368",136]
["1,2,4-triazole","1,2,4-triazole","C045575","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"27810596","Design, synthesis, and biological evaluation of novel alkylsulfanyl-1,2,4-triazoles as cis-restricted combretastatin A-4 analogues.","27810596",136]
["1,2,4-triazole","1,2,4-triazole","C045575","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"29031074","Synthesis, antiproliferative, anti-tubulin activity, and docking study of new 1,2,4-triazoles as potential combretastatin analogues.","29031074",136]
["1,2,4-triazole","1,2,4-triazole","C045575","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2006,"16562946","Electronic properties, redox behavior, and interactions with H2O2 of pH-sensitive hydroxyphenyl-1,2,4-triazole-based oxovanadium(V) complexes.","16562946",136]
["1,2,4-triazole","1,2,4-triazole","C045575","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"17397114","Titanium dioxide photoinduced degradation of some pesticide/fungicide precursors.","17397114",136]
["1,2,4-triazole","1,2,4-triazole","C045575","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2011,"21607272","Mononuclear copper(II) complexes with 3,5-substituted-4-salicylidene-amino-3,5-dimethyl-1,2,4-triazole: synthesis, structure and potent inhibition of protein tyrosine phosphatases.","21607272",136]
["1,2,4-triazole","1,2,4-triazole","C045575","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"24577255","New 1,2,4-triazole-based azo-azomethine dye. Part III: Synthesis, characterization, thermal property, spectrophotometric and computational studies.","24577255",136]
["1,2,4-triazole(1,5a)pyrimidine","1,2,4-triazole(1,5a)pyrimidine","C419143","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"24077182","A novel [1,2,4] triazolo [1,5-a] pyrimidine-based phenyl-linked steroid dimer: synthesis and its cytotoxic activity.","24077182",136]
["1,2,4-triazole(1,5a)pyrimidine","1,2,4-triazole(1,5a)pyrimidine","C419143","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"24077182","A novel [1,2,4] triazolo [1,5-a] pyrimidine-based phenyl-linked steroid dimer: synthesis and its cytotoxic activity.","24077182",136]
["1,2,4-triazole-3-carboxamide","1,2,4-triazole-3-carboxamide","C017957","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2018,"29396364","Spirohydantoins and 1,2,4-triazole-3-carboxamide derivatives as inhibitors of histone deacetylase: Design, synthesis, and biological evaluation.","29396364",136]
["1,2,4-tribromobenzene","1,2,4-tribromobenzene","C026924","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,1998,"9456081","Hepatotoxicity of brominated benzenes: relationship between chemical structure and hepatotoxic effects in acute intoxication of mice.","9456081",136]
["1,2,4-trichlorobenzene","1,2,4-trichlorobenzene","C009947","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,1,2006,"16478460","Surveying biotransformations with à la carte genetic traps: translating dehydrochlorination of lindane (gamma-hexachlorocyclohexane) into lacZ-based phenotypes.","16478460",136]
["1,2,4-trihydroxyanthraquinone Be","1,2,4-trihydroxyanthraquinone Be","C116389","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1998,"9861689","Study on a fluorescence-enhanced system of 1,2,4-trihydroxyanthroquinone-Be(2+)-DNA.","9861689",136]
["1,2,4-trinitrobenzene","1,2,4-trinitrobenzene","C043308","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1984,"6238023","Selective modification of myosin SH1 with 1,2,4-trinitrobenzene. VIII. Thiols of myosin.","6238023",136]
["1,2,4-trioxane","1,2,4-trioxane","C503429","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2006,"17181166","Biological mechanisms of action of novel C-10 non-acetal trioxane dimers in prostate cancer cell lines.","17181166",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C1667,B1667)","v":"1,2,4-trioxane"},"1,2,4-trioxane","C503429","5_KE",768,5,"Cytotoxicity","Increase",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J1667,K1667)","v":"Apoptosis"},"D017209","Apoptosis",1,2,2016,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q1667,Q1667)","v":"27821095"},"Treatment of a chemoresistant neuroblastoma cell line with the antimalarial ozonide OZ513.","27821095",136]
["1,2,4-trioxane","1,2,4-trioxane","C503429","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20804120","Heme as trigger and target for trioxane-containing antimalarial drugs.","20804120",136]
["1,2,4-trioxane","1,2,4-trioxane","C503429","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"24056020","Design, synthesis, and in vitro cancer cell growth inhibition evaluation and antimalarial testing of trioxanes installed in cyclic 2-enoate substructures.","24056020",136]
["1,2,4-trioxane","1,2,4-trioxane","C503429","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2006,"16435367","Chemical kinetics and aqueous degradation pathways of a new class of synthetic ozonide antimalarials.","16435367",136]
["1,2,4-trioxane","1,2,4-trioxane","C503429","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2008,"18487455","Acidity enhances the formation of a persistent ozonide at aqueous ascorbate/ozone gas interfaces.","18487455",136]
["1,2,5,6-dibenzanthracene","1,2,5,6-dibenzanthracene","C026486","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"24390408","Conditions for sample preparation and quantitative HPLC/MS-MS analysis of bulky adducts to serum albumin with diolepoxides of polycyclic aromatic hydrocarbons as models.","24390408",136]
["1,2,5,8-tetrahydroxy anthraquinone","1,2,5,8-tetrahydroxy anthraquinone","C543211","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2009,"19432557","Quinalizarin as a potent, selective and cell-permeable inhibitor of protein kinase CK2.","19432557",136]
["1,2,5,8-tetrahydroxy anthraquinone","1,2,5,8-tetrahydroxy anthraquinone","C543211","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2016,"26781335","Quinalizarin enhances radiosensitivity of nasopharyngeal carcinoma cells partially by suppressing SHP-1 expression.","26781335",136]
["1,2,5,8-tetrahydroxy anthraquinone","1,2,5,8-tetrahydroxy anthraquinone","C543211","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2016,"26899328","[The CK2 inhibitor quninalizarin enhances the anti-proliferative effect of icotinib on EGFR-TKIs-resistant cell lines and its underlying mechanisms].","26899328",136]
["1,2,5,8-tetrahydroxy anthraquinone","1,2,5,8-tetrahydroxy anthraquinone","C543211","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2016,"26781335","Quinalizarin enhances radiosensitivity of nasopharyngeal carcinoma cells partially by suppressing SHP-1 expression.","26781335",136]
["1,2,5,8-tetrahydroxy anthraquinone","1,2,5,8-tetrahydroxy anthraquinone","C543211","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"26899328","[The CK2 inhibitor quninalizarin enhances the anti-proliferative effect of icotinib on EGFR-TKIs-resistant cell lines and its underlying mechanisms].","26899328",136]
["1,2,5,8-tetrahydroxy anthraquinone","1,2,5,8-tetrahydroxy anthraquinone","C543211","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2009,"19523565","Preconcentration and separation of ultra-trace beryllium using quinalizarine-modified magnetic microparticles.","19523565",136]
["1,2,5-oxadiazole 2-oxide","1,2,5-oxadiazole 2-oxide","C528141","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20435479","Synthesis and evaluation of nitric oxide-releasing derivatives of farnesylthiosalicylic acid as anti-tumor agents.","20435479",136]
["1,2,5-oxadiazole 2-oxide","1,2,5-oxadiazole 2-oxide","C528141","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22710829","Synthesis and biological evaluation of novel furozan-based nitric oxide-releasing derivatives of oridonin as potential anti-tumor agents.","22710829",136]
["1,2,5-oxadiazole 2-oxide","1,2,5-oxadiazole 2-oxide","C528141","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24929292","Design, synthesis and biological evaluation of hybrid bioisoster derivatives of N-acylhydrazone and furoxan groups with potential and selective anti-Trypanosoma cruzi activity.","24929292",136]
["1,2,5-oxadiazole 2-oxide","1,2,5-oxadiazole 2-oxide","C528141","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"26004429","Synthesis and antitumor evaluation of novel hybrids of phenylsulfonylfuroxan and epiandrosterone/dehydroepiandrosterone derivatives.","26004429",136]
["1,2,5-oxadiazole 2-oxide","1,2,5-oxadiazole 2-oxide","C528141","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"26970663","In vivo phase II-enzymes inducers, as potential chemopreventive agents, based on the chalcone and furoxan skeletons.","26970663",136]
["1,2,5-selenadiazolo-(3,4-d)pyrimidine-5,7-(4H,6H)-dione","1,2,5-selenadiazolo-(3,4-d)pyrimidine-5,7-(4H,6H)-dione","C529179","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2008,"18222058","Mitochondria-mediated apoptosis in human breast carcinoma MCF-7 cells induced by a novel selenadiazole derivative.","18222058",136]
["1,2,7,8-tetrachlorodibenzo-p-dioxin","1,2,7,8-tetrachlorodibenzo-p-dioxin","C445379","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Atrophy","D001284","Atrophy",1,2,2006,"16545771","A potential endogenous ligand for the aryl hydrocarbon receptor has potent agonist activity in vitro and in vivo.","16545771",136]
["1,2,9,10-tetrachlorodecane","1,2,9,10-tetrachlorodecane","C467419","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2002,"11996156","Homogeneous degradation of 1,2,9,10-tetrachlorodecane in aqueous solutions using hydrogen peroxide, iron and UV light.","11996156",136]
["1,2,9,9a-tetrahydrocyclopropa(1,2-c)benz(1,2-e)indol-4-one","1,2,9,9a-tetrahydrocyclopropa(1,2-c)benz(1,2-e)indol-4-one","C506823","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28090614","Synthesis and anticancer activity of benzoselenophene and heteroaromatic derivatives of 1,2,9,9a-tetrahydrocyclopropa[c]benzo[e]indol-4-one (CBI).","28090614",136]
["1,2,9,9a-tetrahydrocyclopropa(1,2-c)benz(1,2-e)indol-4-one","1,2,9,9a-tetrahydrocyclopropa(1,2-c)benz(1,2-e)indol-4-one","C506823","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2006,"16908174","Synthesis and antitumor activity of CBI-bearing ester and carbamate prodrugs of CC-1065 analogue.","16908174",136]
["1,2,9,9a-tetrahydrocyclopropa(1,2-c)benz(1,2-e)indol-4-one","1,2,9,9a-tetrahydrocyclopropa(1,2-c)benz(1,2-e)indol-4-one","C506823","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"25087870","Mechanism of action of AminoCBIs: highly reactive but highly cytotoxic analogues of the duocarmycins.","25087870",136]
["1,24-dihydroxyvitamin D2","1,24-dihydroxyvitamin D2","C063087","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2005,"15816543","1,24(S)-dihydroxyvitamin D2, an endogenous vitamin D2 metabolite, inhibits growth of breast cancer cells and tumors.","15816543",136]
["1,25-dihydroxy-16,23-diene vitamin D3","1,25-dihydroxy-16,23-diene vitamin D3","C116777","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2006,"16395705","Cooperative antitumor effects of vitamin D3 derivatives and rosemary preparations in a mouse model of myeloid leukemia.","16395705",136]
["1,25-dihydroxy-16-ene-vitamin D3","1,25-dihydroxy-16-ene-vitamin D3","C087630","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2001,"11179741","Differential activities of 1alpha,25-dihydroxy-16-ene-vitamin D(3) analogs and their 3-epimers on human promyelocytic leukemia (HL-60) cell differentiation and apoptosis.","11179741",136]
["1,25-dihydroxy-19-norprevitamin D3","1,25-dihydroxy-19-norprevitamin D3","C083611","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2007,"17553915","Kinetic studies of 25-hydroxy-19-nor-vitamin D3 and 1 alpha,25-dihydroxy-19-nor-vitamin D3 hydroxylation by CYP27B1 and CYP24A1.","17553915",136]
["1,25-dihydroxy-19-norvitamin D3","1,25-dihydroxy-19-norvitamin D3","C083610","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2000,"10712934","Catalytic asymmetric syntheses and biological activities of singly dehydroxylated 19-nor-1alpha,25-dihydroxyvitamin D(3) A-ring analogs in cancer cell differentiation and apoptosis.","10712934",136]
["1,25-dihydroxy-20S-21(3-hydroxy-3-methyl-butyl)-23-yne-26,27-hexafluoro-vitamin D3","1,25-dihydroxy-20S-21(3-hydroxy-3-methyl-butyl)-23-yne-26,27-hexafluoro-vitamin D3","C514501","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2006,"16777406","Novel Gemini-vitamin D3 analog inhibits tumor cell growth and modulates the Akt/mTOR signaling pathway.","16777406",136]
["1,25-dihydroxy-21-(3-hydroxy-3-methyl-4,4,4-tributyl)-23-yne-26,27-hexafluorocholecalciferol","1,25-dihydroxy-21-(3-hydroxy-3-methyl-4,4,4-tributyl)-23-yne-26,27-hexafluorocholecalciferol","C552206","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25541438","HES1-mediated inhibition of Notch1 signaling by a Gemini vitamin D analog leads to decreased CD44(+)/CD24(-/low) tumor-initiating subpopulation in basal-like breast cancer.","25541438",136]
["1,25-dihydroxy-21-(3-hydroxy-3-methyl-4,4,4-tributyl)-23-yne-26,27-hexafluorocholecalciferol","1,25-dihydroxy-21-(3-hydroxy-3-methyl-4,4,4-tributyl)-23-yne-26,27-hexafluorocholecalciferol","C552206","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2010,"20304052","Gemini vitamin D analog suppresses ErbB2-positive mammary tumor growth via inhibition of ErbB2/AKT/ERK signaling.","20304052",136]
["1,25-dihydroxy-21-(3-hydroxy-3-methyl-4,4,4-tributyl)-23-yne-26,27-hexafluorocholecalciferol","1,25-dihydroxy-21-(3-hydroxy-3-methyl-4,4,4-tributyl)-23-yne-26,27-hexafluorocholecalciferol","C552206","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24691501","Inhibition of the transition of ductal carcinoma in situ to invasive ductal carcinoma by a Gemini vitamin D analog.","24691501",136]
["1,25-dihydroxy-21-(3-hydroxy-3-methyl-4,4,4-tributyl)-23-yne-26,27-hexafluorocholecalciferol","1,25-dihydroxy-21-(3-hydroxy-3-methyl-4,4,4-tributyl)-23-yne-26,27-hexafluorocholecalciferol","C552206","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25541438","HES1-mediated inhibition of Notch1 signaling by a Gemini vitamin D analog leads to decreased CD44(+)/CD24(-/low) tumor-initiating subpopulation in basal-like breast cancer.","25541438",136]
["1,25-dihydroxy-21-(3-hydroxy-3-methyl-4,4,4-tributyl)-23-yne-26,27-hexafluorocholecalciferol","1,25-dihydroxy-21-(3-hydroxy-3-methyl-4,4,4-tributyl)-23-yne-26,27-hexafluorocholecalciferol","C552206","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"27650654","Structural analysis and biological activities of BXL0124, a gemini analog of vitamin D.","27650654",136]
["1,25-dihydroxy-21-(3-hydroxy-3-methyl-4,4,4-tributyl)-23-yne-26,27-hexafluorocholecalciferol","1,25-dihydroxy-21-(3-hydroxy-3-methyl-4,4,4-tributyl)-23-yne-26,27-hexafluorocholecalciferol","C552206","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"27923595","Vitamin D compounds inhibit cancer stem-like cells and induce differentiation in triple negative breast cancer.","27923595",136]
["1,25-dihydroxy-21-(3-hydroxy-3-methylbutyl)vitamin D(3)","1,25-dihydroxy-21-(3-hydroxy-3-methylbutyl)vitamin D(3)","C411462","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2006,"16737686","Gene expression profiling changes induced by a novel Gemini Vitamin D derivative during the progression of breast cancer.","16737686",136]
["1,25-dihydroxy-21-(3-hydroxy-3-methylbutyl)vitamin D(3)","1,25-dihydroxy-21-(3-hydroxy-3-methylbutyl)vitamin D(3)","C411462","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2006,"16737686","Gene expression profiling changes induced by a novel Gemini Vitamin D derivative during the progression of breast cancer.","16737686",136]
["1,25-dihydroxy-21-(3-hydroxy-3-methylbutyl)vitamin D(3)","1,25-dihydroxy-21-(3-hydroxy-3-methylbutyl)vitamin D(3)","C411462","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2007,"17254779","Calcitriol derivatives with two different side chains at C-20 III. An epimeric pair of the gemini family with unprecedented antiproliferative effects on tumor cells and renin mRNA expression inhibition.","17254779",136]
["1,25-dihydroxy-21-(3-hydroxy-3-methylbutyl)vitamin D(3)","1,25-dihydroxy-21-(3-hydroxy-3-methylbutyl)vitamin D(3)","C411462","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2008,"18852491","Synergistic antileukemic activity of carnosic acid-rich rosemary extract and the 19-nor Gemini vitamin D analogue in a mouse model of systemic acute myeloid leukemia.","18852491",136]
["1,25-dihydroxy-21-(3-hydroxy-3-methylbutyl)vitamin D(3)","1,25-dihydroxy-21-(3-hydroxy-3-methylbutyl)vitamin D(3)","C411462","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2010,"20304052","Gemini vitamin D analog suppresses ErbB2-positive mammary tumor growth via inhibition of ErbB2/AKT/ERK signaling.","20304052",136]
["1,25-dihydroxy-21-(3-hydroxy-3-methylbutyl)vitamin D(3)","1,25-dihydroxy-21-(3-hydroxy-3-methylbutyl)vitamin D(3)","C411462","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"23775785","Novel Gemini vitamin D3 analogs: large structure/function analysis and ability to induce antimicrobial peptide.","23775785",136]
["1,25-dihydroxy-21-(3-hydroxy-3-methylbutyl)vitamin D(3)","1,25-dihydroxy-21-(3-hydroxy-3-methylbutyl)vitamin D(3)","C411462","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24691501","Inhibition of the transition of ductal carcinoma in situ to invasive ductal carcinoma by a Gemini vitamin D analog.","24691501",136]
["1,25-dihydroxy-21-(3-hydroxy-3-methylbutyl)vitamin D(3)","1,25-dihydroxy-21-(3-hydroxy-3-methylbutyl)vitamin D(3)","C411462","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2010,"19900670","Aggregation behavior of N-carboxyethylchitosan in aqueous solution: effects of pH, polymer concentration, and presence of a gemini surfactant.","19900670",136]
["1,25-dihydroxy-21-(3-hydroxy-3-methylbutyl)vitamin D(3)","1,25-dihydroxy-21-(3-hydroxy-3-methylbutyl)vitamin D(3)","C411462","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"22502732","pH-responsive surface activity and solubilization with novel pyrrolidone-based Gemini surfactants.","22502732",136]
["1,25-dihydroxy-21-(3-hydroxy-3-methylbutyl)vitamin D(3)","1,25-dihydroxy-21-(3-hydroxy-3-methylbutyl)vitamin D(3)","C411462","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"24712085","Physicochemical properties of oleic acid-based partially fluorinated gemini surfactants.","24712085",136]
["1,25-dihydroxy-21-(3-hydroxy-3-methylbutyl)vitamin D(3)","1,25-dihydroxy-21-(3-hydroxy-3-methylbutyl)vitamin D(3)","C411462","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"24712086","Effects of spacer chain length of amino acid-based gemini surfactants on wormlike micelle formation.","24712086",136]
["1,25-dihydroxy-21-(3-hydroxy-3-methylbutyl)vitamin D(3)","1,25-dihydroxy-21-(3-hydroxy-3-methylbutyl)vitamin D(3)","C411462","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2017,"28678285","New pH-responsive gemini lipid derived co-liposomes for efficacious doxorubicin delivery to drug resistant cancer cells.","28678285",136]
["1,25-dihydroxy-21-(3-hydroxy-3-methylbutyl)vitamin D(3)","1,25-dihydroxy-21-(3-hydroxy-3-methylbutyl)vitamin D(3)","C411462","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2006,"16737686","Gene expression profiling changes induced by a novel Gemini Vitamin D derivative during the progression of breast cancer.","16737686",136]
["1,25-dihydroxy-23-thiavitamin D3","1,25-dihydroxy-23-thiavitamin D3","C074474","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2000,"11194893","Comparative inhibitory effects of vitamin D3 and an analogue on normal and psoriatic epidermis in organ culture.","11194893",136]
["1,25-dihydroxy-26-(hydroxymethyl)-26-methylvitamin D3","1,25-dihydroxy-26-(hydroxymethyl)-26-methylvitamin D3","C560303","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21524075","Synthesis and biological evaluation of 1α,25-dihydroxyvitamin D(3) analogues hydroxymethylated at C-26.","21524075",136]
["1,25-dihydroxy-26-(hydroxymethyl)vitamin D3","1,25-dihydroxy-26-(hydroxymethyl)vitamin D3","C560304","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21524075","Synthesis and biological evaluation of 1α,25-dihydroxyvitamin D(3) analogues hydroxymethylated at C-26.","21524075",136]
["1,25-dihydroxyergocalciferol","1,25-dihydroxyergocalciferol","C003564","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2004,"15178742","Accelerated mammary gland development during pregnancy and delayed postlactational involution in vitamin D3 receptor null mice.","15178742",136]
["1,25-dihydroxyergocalciferol","1,25-dihydroxyergocalciferol","C003564","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2007,"18306931","The effect of combined treatment on head and neck human cancer cell lines with novel analogs of calcitriol and cytostatics.","18306931",136]
["1,25-dihydroxyergocalciferol","1,25-dihydroxyergocalciferol","C003564","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2016,"26365556","Novel analogs of 1,25-dihydroxyvitamin D2 combined with a plant polyphenol as highly efficient inducers of differentiation in human acute myeloid leukemia cells.","26365556",136]
["1,25-dihydroxyergocalciferol","1,25-dihydroxyergocalciferol","C003564","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25912039","Vitamin D and 1,25(OH)2D regulation of T cells.","25912039",136]
["1,25-dihydroxyergocalciferol","1,25-dihydroxyergocalciferol","C003564","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"26492238","Antiproliferative Activity and in Vivo Toxicity of Double-Point Modified Analogs of 1,25-Dihydroxyergocalciferol.","26492238",136]
["1,25-dihydroxyergocalciferol","1,25-dihydroxyergocalciferol","C003564","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"26760999","Antiproliferative Activity of Double Point Modified Analogs of 1,25-Dihydroxyvitamin D₂ Against Human Malignant Melanoma Cell Lines.","26760999",136]
["1,25-dihydroxyergocalciferol","1,25-dihydroxyergocalciferol","C003564","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2016,"26511971","Differential interference of vitamin D analogs PRI-1906, PRI-2191, and PRI-2205 with the renewal of human colon cancer cells refractory to treatment with 5-fluorouracil.","26511971",136]
["1,25-dihydroxyvitamin D","1,25-dihydroxyvitamin D","C097949","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2004,"15225840","1,25-Dihydroxyvitamin D and three low-calcemic analogs decrease UV-induced DNA damage via the rapid response pathway.","15225840",136]
["1,25-dihydroxyvitamin D","1,25-dihydroxyvitamin D","C097949","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2007,"17959142","Enhanced effects of guggulsterone plus 1,25(OH)2D3 on 3T3-L1 adipocytes.","17959142",136]
["1,25-dihydroxyvitamin D","1,25-dihydroxyvitamin D","C097949","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2008,"18200516","Vitamin D derivatives induce apoptosis and downregulate ICAM-1 levels in peripheral blood mononuclear cells of inflammatory bowel disease patients.","18200516",136]
["1,25-dihydroxyvitamin D","1,25-dihydroxyvitamin D","C097949","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"20089040","Vitamin D stimulates apoptosis in gastric cancer cells in synergy with trichostatin A /sodium butyrate-induced and 5-aza-2'-deoxycytidine-induced PTEN upregulation.","20089040",136]
["1,25-dihydroxyvitamin D","1,25-dihydroxyvitamin D","C097949","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"21816906","MicroRNA-32 upregulation by 1,25-dihydroxyvitamin D3 in human myeloid leukemia cells leads to Bim targeting and inhibition of AraC-induced apoptosis.","21816906",136]
["1,25-dihydroxyvitamin D","1,25-dihydroxyvitamin D","C097949","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22931489","Buthionine sulfoximine and 1,25-dihydroxyvitamin D induce apoptosis in breast cancer cells via induction of reactive oxygen species.","22931489",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C1731,B1731)","v":"1,25-dihydroxyvitamin D"},"1,25-dihydroxyvitamin D","C097949","5_KE",768,5,"Cytotoxicity","Increase",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J1731,K1731)","v":"Apoptosis"},"D017209","Apoptosis",1,2,2013,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q1731,Q1731)","v":"23503652"},"Tumor suppressor microRNAs, miR-100 and -125b, are regulated by 1,25-dihydroxyvitamin D in primary prostate cells and in patient tissue.","23503652",136]
["1,25-dihydroxyvitamin D","1,25-dihydroxyvitamin D","C097949","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23912386","Vitamin D in the cancer patient.","23912386",136]
["1,25-dihydroxyvitamin D","1,25-dihydroxyvitamin D","C097949","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2014,"25150940","Vitamin D modulates the association of circulating insulin-like growth factor-1 with carotid artery intima-media thickness.","25150940",136]
["1,25-dihydroxyvitamin D","1,25-dihydroxyvitamin D","C097949","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25940772","Vitamin D controls apoptosis and proliferation of cutaneous T-cell lymphoma cells.","25940772",136]
["1,25-dihydroxyvitamin D","1,25-dihydroxyvitamin D","C097949","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"26562100","Effects of Placental Ischemia Are Attenuated by 1,25-Dihydroxyvitamin D Treatment and Associated with Reduced Apoptosis and Increased Autophagy.","26562100",136]
["1,25-dihydroxyvitamin D","1,25-dihydroxyvitamin D","C097949","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2006,"16367934","1,25-Dihydroxyvitamin D inhibits lipopolysaccharide-induced immune activation in human endothelial cells.","16367934",136]
["1,25-dihydroxyvitamin D","1,25-dihydroxyvitamin D","C097949","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2008,"18200516","Vitamin D derivatives induce apoptosis and downregulate ICAM-1 levels in peripheral blood mononuclear cells of inflammatory bowel disease patients.","18200516",136]
["1,25-dihydroxyvitamin D","1,25-dihydroxyvitamin D","C097949","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2009,"19056306","Vitamin D and growth hormone regulate growth hormone/insulin-like growth factor (GH-IGF) axis gene expression in human fetal epiphyseal chondrocytes.","19056306",136]
["1,25-dihydroxyvitamin D","1,25-dihydroxyvitamin D","C097949","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20583132","1,25-dihydroxyvitamin D(3) and PI3K/AKT inhibitors synergistically inhibit growth and induce senescence in prostate cancer cells.","20583132",136]
["1,25-dihydroxyvitamin D","1,25-dihydroxyvitamin D","C097949","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2010,"20665397","Calcium and vitamin D in sarcoidosis: how to assess and manage.","20665397",136]
["1,25-dihydroxyvitamin D","1,25-dihydroxyvitamin D","C097949","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"22044285","1,25-Dihydroxyvitamin D3 inhibits proliferation but not the suppressive function of regulatory T cells in the absence of antigen-presenting cells.","22044285",136]
["1,25-dihydroxyvitamin D","1,25-dihydroxyvitamin D","C097949","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23114406","Dietary supplementation with vitamin D stimulates intestinal epithelial cell turnover after massive small bowel resection in rats.","23114406",136]
["1,25-dihydroxyvitamin D","1,25-dihydroxyvitamin D","C097949","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23503652","Tumor suppressor microRNAs, miR-100 and -125b, are regulated by 1,25-dihydroxyvitamin D in primary prostate cells and in patient tissue.","23503652",136]
["1,25-dihydroxyvitamin D","1,25-dihydroxyvitamin D","C097949","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23619337","1,25-dihydroxyvitamin D regulation of glucose metabolism in Harvey-ras transformed MCF10A human breast epithelial cells.","23619337",136]
["1,25-dihydroxyvitamin D","1,25-dihydroxyvitamin D","C097949","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2013,"23845396","Vitamin D in autoimmune liver disease.","23845396",136]
["1,25-dihydroxyvitamin D","1,25-dihydroxyvitamin D","C097949","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2013,"23879537","Vitamin D and microRNAs in bone.","23879537",136]
["1,25-dihydroxyvitamin D","1,25-dihydroxyvitamin D","C097949","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24280059","Vitamin D signaling regulates proliferation, differentiation, and myotube size in C2C12 skeletal muscle cells.","24280059",136]
["1,25-dihydroxyvitamin D","1,25-dihydroxyvitamin D","C097949","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25846868","Restoration of the anti-proliferative and anti-migratory effects of 1,25-dihydroxyvitamin D by silibinin in vitamin D-resistant colon cancer cells.","25846868",136]
["1,25-dihydroxyvitamin D","1,25-dihydroxyvitamin D","C097949","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25940772","Vitamin D controls apoptosis and proliferation of cutaneous T-cell lymphoma cells.","25940772",136]
["1,25-dihydroxyvitamin D","1,25-dihydroxyvitamin D","C097949","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2015,"26170242","Hepatocellular carcinoma cells express 25(OH)D-1α-hydroxylase and are able to convert 25(OH)D to 1α,25(OH)₂D, leading to the 25(OH)D-induced growth inhibition.","26170242",136]
["1,25-dihydroxyvitamin D","1,25-dihydroxyvitamin D","C097949","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"26899162","Vitamin D decreases adipocyte lipid storage and increases NAD-SIRT1 pathway in 3T3-L1 adipocytes.","26899162",136]
["1,25-dihydroxyvitamin D","1,25-dihydroxyvitamin D","C097949","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27552186","1α,25-Dihydroxyvitamin D Inhibits the Metastatic Capability of MCF10CA1a and MDA-MB-231 Cells in an In Vitro Model of Breast to Bone Metastasis.","27552186",136]
["1,25-dihydroxyvitamin D","1,25-dihydroxyvitamin D","C097949","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2017,"28549199","Effect of 1,25(OH2D3 on the proliferation of human mesangial cells and their expression of Ki67.","28549199",136]
["1,25-dihydroxyvitamin D","1,25-dihydroxyvitamin D","C097949","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28669663","1,25(OH)2 vitamin D(3) contributes to osteoclast-like trans-differentiation of malignant plasma cells.","28669663",136]
["1,25-dihydroxyvitamin D","1,25-dihydroxyvitamin D","C097949","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Nasal Mucosa","D009297","Nasal Mucosa",1,2,2017,"29061851","Hormonal vitamin D upregulates tissue-specific PD-L1 and PD-L2 surface glycoprotein expression in human but not mouse.","29061851",136]
["1,25-dihydroxyvitamin D3-3-bromoacetate","1,25-dihydroxyvitamin D3-3-bromoacetate","C104313","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2003,"12874825","1alpha,25-Dihydroxyvitamin D3-3beta-(2)-bromoacetate, an affinity labeling derivative of 1alpha,25-dihydroxyvitamin D3 displays strong antiproliferative and cytotoxic behavior in prostate cancer cells.","12874825",136]
["1,25-dihydroxyvitamin D3-3-bromoacetate","1,25-dihydroxyvitamin D3-3-bromoacetate","C104313","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2004,"15585637","Inhibition of proliferation and induction of apoptosis by 25-hydroxyvitamin D3-3beta-(2)-Bromoacetate, a nontoxic and vitamin D receptor-alkylating analog of 25-hydroxyvitamin D3 in prostate cancer cells.","15585637",136]
["1,25-dihydroxyvitamin D3-3-bromoacetate","1,25-dihydroxyvitamin D3-3-bromoacetate","C104313","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"21149334","A vitamin D receptor-alkylating derivative of 1α,25-dihydroxyvitamin D3 inhibits growth of human kidney cancer cells and suppresses tumor growth.","21149334",136]
["1,25-dihydroxyvitamin D3-3-bromoacetate","1,25-dihydroxyvitamin D3-3-bromoacetate","C104313","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23314787","1α,25-Dihydroxyvitamin-D3-3-bromoacetate regulates AKT/mTOR signaling cascades: a therapeutic agent for psoriasis.","23314787",136]
["1,25-dihydroxyvitamin D3-3-bromoacetate","1,25-dihydroxyvitamin D3-3-bromoacetate","C104313","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"24036370","1,25-Dihydroxyvitamin D3-3-bromoacetate, a novel vitamin D analog induces immunosuppression through PI3K/Akt/mTOR signaling cascade.","24036370",136]
["1,25-dihydroxyvitamin D3-3-bromoacetate","1,25-dihydroxyvitamin D3-3-bromoacetate","C104313","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"26909599","Genome-wide functional genetic screen with the anticancer agent AMPI-109 identifies PRL-3 as an oncogenic driver in triple-negative breast cancers.","26909599",136]
["1,25-dihydroxyvitamin D3-3-bromoacetate","1,25-dihydroxyvitamin D3-3-bromoacetate","C104313","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2004,"15585637","Inhibition of proliferation and induction of apoptosis by 25-hydroxyvitamin D3-3beta-(2)-Bromoacetate, a nontoxic and vitamin D receptor-alkylating analog of 25-hydroxyvitamin D3 in prostate cancer cells.","15585637",136]
["1,25-dihydroxyvitamin D3-3-bromoacetate","1,25-dihydroxyvitamin D3-3-bromoacetate","C104313","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20651329","Anti-growth effect of 1,25-dihydroxyvitamin D3-3-bromoacetate alone or in combination with 5-amino-imidazole-4-carboxamide-1-beta-4-ribofuranoside in pancreatic cancer cells.","20651329",136]
["1,25-dihydroxyvitamin D3-3-bromoacetate","1,25-dihydroxyvitamin D3-3-bromoacetate","C104313","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"21149334","A vitamin D receptor-alkylating derivative of 1α,25-dihydroxyvitamin D3 inhibits growth of human kidney cancer cells and suppresses tumor growth.","21149334",136]
["1,25-dihydroxyvitamin D3-3-bromoacetate","1,25-dihydroxyvitamin D3-3-bromoacetate","C104313","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23314787","1α,25-Dihydroxyvitamin-D3-3-bromoacetate regulates AKT/mTOR signaling cascades: a therapeutic agent for psoriasis.","23314787",136]
["1,25-dihydroxyvitamin D3-3-bromoacetate","1,25-dihydroxyvitamin D3-3-bromoacetate","C104313","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"24036370","1,25-Dihydroxyvitamin D3-3-bromoacetate, a novel vitamin D analog induces immunosuppression through PI3K/Akt/mTOR signaling cascade.","24036370",136]
["1,2-benzenedithiol","1,2-benzenedithiol","C102217","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1996,"8811900","Quantitative determination of isothiocyanates, dithiocarbamates, carbon disulfide, and related thiocarbonyl compounds by cyclocondensation with 1,2-benzenedithiol.","8811900",136]
["1,2-benzisothiazoline-3-one","1,2-benzisothiazoline-3-one","C015699","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24656804","1,2-benzisothiazol-3-one derivatives as a novel class of small-molecule caspase-3 inhibitors.","24656804",136]
["1,2-benzisothiazoline-3-one","1,2-benzisothiazoline-3-one","C015699","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"27343839","Cross-reactivity between methylisothiazolinone, octylisothiazolinone and benzisothiazolinone using a modified local lymph node assay.","27343839",136]
["1,2-benzisothiazoline-3-one","1,2-benzisothiazoline-3-one","C015699","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1990,"2292521","Chemical reactivity of some isothiazolone biocides.","2292521",136]
["1,2-benzisothiazoline-3-one","1,2-benzisothiazoline-3-one","C015699","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1996,"8863808","Biophysical characterization of zinc ejection from HIV nucleocapsid protein by anti-HIV 2,2'-dithiobis[benzamides] and benzisothiazolones.","8863808",136]
["1,2-benzodithiol-3-one-1,1-dioxide","1,2-benzodithiol-3-one-1,1-dioxide","C414667","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2010,"20204198","Thiol-dependent DNA cleavage by aminomethylated Beaucage's reagent.","20204198",136]
["1,2-bis(10(2',4'-hexadienoyloxy)decanoyl)-sn-glycero-3-phosphocholine","1,2-bis(10(2',4'-hexadienoyloxy)decanoyl)-sn-glycero-3-phosphocholine","C077390","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1996,"8794759","Effect of liposomal composition on photoactivated liposome fusion.","8794759",136]
["1,2-bis(11-aminoundecanoyl)-3-glucopyranosylglycerol","1,2-bis(11-aminoundecanoyl)-3-glucopyranosylglycerol","C478012","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2003,"12845809","[The synthesis of a glucosyldiglyceride for constructing pH-sensitive liposomes].","12845809",136]
["1,2'-bis(2-(1,3-benzothiazol-2-yl)phenoxy)-2-ethoxyethane","1,2'-bis(2-(1,3-benzothiazol-2-yl)phenoxy)-2-ethoxyethane","C000594738","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"24907753","Electroanalytical studies on Cu (II) ion-selective sensor of coated pyrolytic graphite electrodes based on N2S2O2 and N2S2O3 heterocyclic benzothiazol ligands.","24907753",136]
["1,2-bis(2-amino-5,6-difluorophenoxy)ethane-N,N,N',N'-tetraacetic acid","1,2-bis(2-amino-5,6-difluorophenoxy)ethane-N,N,N',N'-tetraacetic acid","C087511","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1994,"8203496","NMR-sensitive fluorinated and fluorescent intracellular calcium ion indicators with high dissociation constants.","8203496",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","1_MIE",867,1,"Intracellular pH","Decrease","Acid-Base Equilibrium","D000136","Acid-Base Equilibrium",2,2,2001,"11340305","Regulation of tubular cell MCP-1 production by intracellular ions: a role for sodium and calcium.","11340305",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,1999,"10528917","Effects of intracellular calcium chelator BAPTA-AM on radiation-induced apoptosis regulated by activation of SAPK/JNK and caspase-3 in MOLT-4 cells.","10528917",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,1999,"10546560","Effects of BAPTA-AM and forskolin on apoptosis and cytochrome c release in photosensitized Chinese hamster V79 cells.","10546560",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2000,"10993480","Inhibitors of Na+/Ca2+ exchanger prevent oxidant-induced intracellular Ca2+ increase and apoptosis in a human hepatoma cell line.","10993480",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2000,"10993483","Slow rise of Ca2+ and slow release of reactive oxygen species are two cross-talked events important in tumour necrosis factor-alpha-mediated apoptosis.","10993483",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2000,"10995836","Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity.","10995836",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2000,"11044207","Regulation of mesangial cell apoptosis and proliferation by intracellular Ca(2+) signals.","11044207",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2000,"11108803","Involvement of the extracellular signal-regulated protein kinase (ERK) pathway in the induction of apoptosis by cadmium chloride in CCRF-CEM cells.","11108803",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2000,"11193025","First and second messenger role of calcium. Survival versus apoptosis in serum-free cultured granulosa explants.","11193025",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2001,"11461958","1,2-bis(2-Aminophenoxy)ethane-N,N,N',N'-tetraacetic acid induces caspase-mediated apoptosis and reactive oxygen species-mediated necrosis in cultured cortical neurons.","11461958",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2001,"11697127","Enhancement of hyperthermia-induced apoptosis by a free radical initiator, 2,2'-azobis (2-amidinopropane) dihydrochloride, in human histiocytic lymphoma U937 cells.","11697127",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2002,"11750901","Depletion of intracellular calcium stores is toxic to SH-SY5Y neuronal cells.","11750901",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2002,"11772941","The voltage-independent B-type Ca2+ channel modulates apoptosis of cardiac myocytes.","11772941",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2002,"11781251","Resistance of leukemic cells to 2-chlorodeoxyadenosine is due to a lack of calcium-dependent cytochrome c release.","11781251",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2002,"11861640","Enhancement of hyperthermia-induced apoptosis by local anesthetics on human histiocytic lymphoma U937 cells.","11861640",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2002,"11861756","Menadione-induced apoptosis: roles of cytosolic Ca(2+) elevations and the mitochondrial permeability transition pore.","11861756",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2002,"11865193","Effects of BAPTA-AM, Forskolin, DSF and Z.VAD.fmk on PDT-induced apoptosis and m-THPC phototoxicity on B16 cells.","11865193",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2002,"11983701","Increase in cytosolic Ca2+ levels through the activation of non-selective cation channels induced by oxidative stress causes mitochondrial depolarization leading to apoptosis-like death in Leishmania donovani promastigotes.","11983701",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C1795,B1795)","v":"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester"},"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","5_KE",768,5,"Cytotoxicity","Increase",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J1795,K1795)","v":"Apoptosis"},"D017209","Apoptosis",1,2,2002,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q1795,Q1795)","v":"12154390"},"Hydrogen peroxide induces apoptosis of osteocytes: involvement of calcium ion and caspase activity.","12154390",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2002,"12429585","Protein kinase C (PKC) dependent induction of tissue factor (TF) by mesangial cells in response to inflammatory mediators and release during apoptosis.","12429585",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2003,"12446691","Annexin-mediated Ca2+ influx regulates growth plate chondrocyte maturation and apoptosis.","12446691",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2002,"12592666","Roles of protein kinase C delta in the accumulation of P53 and the induction of apoptosis in H2O2-treated bovine endothelial cells.","12592666",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2003,"12640029","Two phases of signalling between mitochondria during apoptosis leading to early depolarisation and delayed cytochrome c release.","12640029",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2003,"12808095","Transcriptional program of apoptosis induction following interleukin 2 deprivation: identification of RC3, a calcium/calmodulin binding protein, as a novel proapoptotic factor.","12808095",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2003,"12868490","A free radical initiator, 2,2'-azobis (2-aminopropane) dihydrochloride enhances hyperthermia-induced apoptosis in human uterine cervical cancer cell lines.","12868490",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2003,"14588144","Redox regulation of PI3K/Akt and p53 in bovine aortic endothelial cells exposed to hydrogen peroxide.","14588144",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2004,"15035826","Dose-dependent regulation of superoxide anion on the proliferation, differentiation, apoptosis and necrosis of human hepatoma cells: the role of intracellular Ca 2+.","15035826",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2004,"15039113","1,2-bis(2-aminophenoxy)ethane-N,N,N'N'-tetraacetic acid (BAPTA-AM) inhibits caffeine-induced apoptosis in human neuroblastoma cells.","15039113",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2004,"15182854","Cadmium induces caspase-independent apoptosis in liver Hep3B cells: role for calcium in signaling oxidative stress-related impairment of mitochondria and relocation of endonuclease G and apoptosis-inducing factor.","15182854",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2004,"15183235","Role of intracellular calcium ions and reactive oxygen species in apoptosis induced by ultrasound.","15183235",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2004,"15247222","Calmodulin-mediated activation of Akt regulates survival of c-Myc-overexpressing mouse mammary carcinoma cells.","15247222",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2004,"15351698","Intracellular mechanisms mediating the anti-apoptotic action of gastrin.","15351698",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2004,"15375154","Antiapoptotic activity of Akt is down-regulated by Ca2+ in myocardiac H9c2 cells. Evidence of Ca(2+)-dependent regulation of protein phosphatase 2Ac.","15375154",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2004,"15471881","Delayed and sustained activation of extracellular signal-regulated kinase in human keratinocytes by UVA: implications in carcinogenesis.","15471881",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2004,"15474552","Ge-Jee-Bok-Ryung-Hwan induces apoptosis in human cervical carcinoma HeLa cells--an endoplasmic reticulum stress pathway--.","15474552",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2004,"15533592","Beauvericin induces cytotoxic effects in human acute lymphoblastic leukemia cells through cytochrome c release, caspase 3 activation: the causative role of calcium.","15533592",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25062711","Hepatocyte growth factor suppresses hypoxia/reoxygenation-induced XO activation in cardiac microvascular endothelial cells.","25062711",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28223427","Calcium-Dependent Enhancement by Extracellular Acidity of the Cytotoxicity of Mitochondrial Inhibitors against Melanoma.","28223427",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,1995,"8747601","Induction of apoptotic DNA fragmentation and c-jun downregulation in human myeloid leukemia cells by the permeant Ca2+ chelator BAPTA/AM.","8747601",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,1996,"8886281","A novel DNA cleaving agent, 2,2'-bis(2-aminoethyl)-4,4'-bithiazole, induces thymocyte apoptosis.","8886281",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28223427","Calcium-Dependent Enhancement by Extracellular Acidity of the Cytotoxicity of Mitochondrial Inhibitors against Melanoma.","28223427",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1999,"10335476","Effect of intracellular Ca2+ chelation with the acetoxymethyl ester-derived form of bis(o-aminophenoxy)ethane-N,N,N,N',N'-tetraacetic acid on meiotic division and chromosomal segregation in mouse oocytes.","10335476",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,3,2000,"11032873","Intracellular pH on translocation of protein kinase C isozymes in rat pinealocytes.","11032873",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2001,"11340305","Regulation of tubular cell MCP-1 production by intracellular ions: a role for sodium and calcium.","11340305",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2001,"11703598","Effect of arginine vasopressin and ANP on intracellular pH and cytosolic free [Ca2+] regulation in MDCK cells.","11703598",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2002,"11849637","Activation of distinct signal transduction pathways in Trypanosoma cruzi isolates with differential capacity to invade host cells.","11849637",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2004,"12965889","Arginine vasopressin stimulates H+-ATPase in MDCK cells via V1 (cell Ca2+) and V2 (cAMP) receptors.","12965889",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2003,"14569297","Beta1 integrins are distributed in adhesion structures with fibronectin and caveolin and in coated pits.","14569297",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2004,"14699499","Divalent cations regulate acidity within the lumen and tubulovesicle compartment of gastric parietal cells.","14699499",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2004,"14726961","A cytosolic source of calcium unveiled by hydrogen peroxide with relevance for epithelial cell death.","14726961",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2004,"14981087","Mechanism of collagen activation in human platelets.","14981087",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2005,"15591047","Modulation of the actin cytoskeleton via gelsolin regulates vacuolar H+-ATPase recycling.","15591047",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2017,"28223427","Calcium-Dependent Enhancement by Extracellular Acidity of the Cytotoxicity of Mitochondrial Inhibitors against Melanoma.","28223427",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2017,"28274857","BAPTA-AM decreases cellular pH, inhibits acidocalcisome acidification and autophagy in amino acid-starved T. brucei.","28274857",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,1,2000,"11094090","Ionophore-resistant mutants of Toxoplasma gondii reveal host cell permeabilization as an early event in egress.","11094090",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2001,"11461958","1,2-bis(2-Aminophenoxy)ethane-N,N,N',N'-tetraacetic acid induces caspase-mediated apoptosis and reactive oxygen species-mediated necrosis in cultured cortical neurons.","11461958",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2001,"11642660","BAPTA/AM, an intracellular calcium chelator, induces delayed necrosis by lipoxygenase-mediated free radicals in mouse cortical cultures.","11642660",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2004,"15035826","Dose-dependent regulation of superoxide anion on the proliferation, differentiation, apoptosis and necrosis of human hepatoma cells: the role of intracellular Ca 2+.","15035826",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2004,"15182854","Cadmium induces caspase-independent apoptosis in liver Hep3B cells: role for calcium in signaling oxidative stress-related impairment of mitochondria and relocation of endonuclease G and apoptosis-inducing factor.","15182854",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2004,"15322099","Involvement of inositol 1,4,5-trisphosphate in nicotinic calcium responses in dystrophic myotubes assessed by near-plasma membrane calcium measurement.","15322099",136]
["1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester","C070379","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Olfactory Mucosa","D009831","Olfactory Mucosa",1,2,2003,"12821794","In situ Ca2+ imaging of odor responses in a coronal olfactory epithelium slice.","12821794",136]
["1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","C025603","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2002,"12441138","Putrescine activates oxidative stress dependent apoptotic death in ornithine decarboxylase overproducing mouse myeloma cells.","12441138",136]
["1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","C025603","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2000,"11089555","Basic fibroblast growth factor inhibits apoptosis of spontaneously immortalized granulosa cells by regulating intracellular free calcium levels through a protein kinase Cdelta-dependent pathway.","11089555",136]
["1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","C025603","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2001,"11445671","BAPTA blocks DNA fragmentation and chromatin condensation downstream of caspase-3 and DFF activation in HT-induced apoptosis in HL-60 cells.","11445671",136]
["1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","C025603","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2001,"11529681","Participation of intracellular Ca(2+)/calmodulin and protein kinase(s) in the pathway of apoptosis induced by a Drosophila cell death gene, reaper.","11529681",136]
["1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","C025603","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2002,"11934248","Reactive oxygen species from mitochondria mediate SW480 cells apoptosis induced by Na2SeO3.","11934248",136]
["1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","C025603","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2002,"11992472","Ca(2+)-independent caspase-3 but not Ca(2+)-dependent caspase-2 activation induced by oxidative stress leads to SH-SY5Y human neuroblastoma cell apoptosis.","11992472",136]
["1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","C025603","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2002,"12095229","Discordance between the effect of modulators of calcium on staurosporine-induced apoptosis and staurosporine-induced actin degradation.","12095229",136]
["1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","C025603","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2002,"12127261","Humic acid induces apoptosis in human endothelial cells.","12127261",136]
["1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","C025603","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2002,"12470644","A Ca2+ signal is found upstream of cytochrome c release during apoptosis in HeLa cells.","12470644",136]
["1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","C025603","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2003,"12866791","Exogenous nitric oxide induces apoptosis in Toxoplasma gondii tachyzoites via a calcium signal transduction pathway.","12866791",136]
["1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","C025603","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2003,"12930302","Intracellular calcium pool emptying induces DNA synthesis in HaCaT keratinocytes.","12930302",136]
["1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","C025603","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2004,"12958071","ST1926, a novel and orally active retinoid-related molecule inducing apoptosis in myeloid leukemia cells: modulation of intracellular calcium homeostasis.","12958071",136]
["1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","C025603","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2003,"14512201","Both calcium and ROS as common signals mediate Na(2)SeO(3)-induced apoptosis in SW480 human colonic carcinoma cells.","14512201",136]
["1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","C025603","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2004,"14700736","Alcohol-induced apoptosis of canine cerebral vascular smooth muscle cells: role of extracellular and intracellular calcium ions.","14700736",136]
["1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","C025603","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2004,"15123639","A novel benzodiazepine increases the sensitivity of B cells to receptor stimulation with synergistic effects on calcium signaling and apoptosis.","15123639",136]
["1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","C025603","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2004,"15163545","Signal transduction of p53-independent apoptotic pathway induced by hexavalent chromium in U937 cells.","15163545",136]
["1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","C025603","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2004,"15254339","Calcium-mediated activation of c-Jun NH2-terminal kinase (JNK) and apoptosis in response to cadmium in murine macrophages.","15254339",136]
["1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","C025603","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2004,"15517864","Acute changes in U937 nuclear Ca2+ preceding type 1 \"apoptotic\" programmed cell death due to MK 886.","15517864",136]
["1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","C025603","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2005,"15608674","Inositol 1,4,5-trisphosphate (IP3) receptor type1 (IP3R1) modulates the acquisition of cisplatin resistance in bladder cancer cell lines.","15608674",136]
["1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","C025603","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2005,"15698934","Possible involvement of Ca2+ signaling in rotenone-induced apoptosis in human neuroblastoma SH-SY5Y cells.","15698934",136]
["1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","C025603","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2005,"15950951","Evaluation of the neuronal apoptotic pathways involved in cytoskeletal disruption-induced apoptosis.","15950951",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C1859,B1859)","v":"1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid"},"1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","C025603","5_KE",768,5,"Cytotoxicity","Increase",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J1859,K1859)","v":"Apoptosis"},"D017209","Apoptosis",1,2,1996,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q1859,Q1859)","v":"8886281"},"A novel DNA cleaving agent, 2,2'-bis(2-aminoethyl)-4,4'-bithiazole, induces thymocyte apoptosis.","8886281",136]
["1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","C025603","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2004,"15254339","Calcium-mediated activation of c-Jun NH2-terminal kinase (JNK) and apoptosis in response to cadmium in murine macrophages.","15254339",136]
["1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","C025603","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2000,"11078705","Regulation of the epithelial Na(+) channel by extracellular acidification.","11078705",136]
["1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","C025603","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2001,"11549852","Naloxone inhibits A6 cell Na(+)/H(+) exchange by activating protein kinase C via the mobilization of intracellular calcium.","11549852",136]
["1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","C025603","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2002,"12067708","Direct modulation of volume-regulated anion channels by Ca(2+) chelating agents.","12067708",136]
["1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","C025603","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2001,"11442383","Entropy-controlled solvolytic dissociation kinetics of lanthanide(III) complexes with polyaminocarboxylates in aqueous solutions.","11442383",136]
["1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","C025603","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2001,"11567535","Ratiometric sensing using dual-frequency lifetime discrimination.","11567535",136]
["1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","C025603","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2003,"12529246","Structure-function relationships of AE2 regulation by Ca(i)(2+)-sensitive stimulators NH(4+) and hypertonicity.","12529246",136]
["1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","C025603","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2003,"12654309","Isothermal titration calorimetric procedure to determine protein-metal ion binding parameters in the presence of excess metal ion or chelator.","12654309",136]
["1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","C025603","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2003,"12886028","P2Y(1) receptor activation enhances the rate of rat pinealocyte-induced extracellular acidification via a calcium-dependent mechanism.","12886028",136]
["1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","C025603","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2005,"15623528","Intracellular thiol-mediated modulation of epithelial sodium channel activity.","15623528",136]
["1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","C025603","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,3,1992,"1569129","The increase in intracellular pH associated with Xenopus egg activation is a Ca(2+)-dependent wave.","1569129",136]
["1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","C025603","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2005,"15802262","Acute insult of ammonia leads to calcium-dependent glutamate release from cultured astrocytes, an effect of pH.","15802262",136]
["1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","C025603","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1991,"1904204","Preparation of solutions with free calcium concentration in the nanomolar range using 1,2-bis(o-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid.","1904204",136]
["1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","C025603","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2013,"23494377","Development and in vitro characterization of ratiometric and intensity-based fluorescent ion sensors.","23494377",136]
["1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","C025603","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1987,"3113491","The effect of temperature and ionic strength on the apparent Ca-affinity of EGTA and the analogous Ca-chelators BAPTA and dibromo-BAPTA.","3113491",136]
["1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","C025603","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1994,"8201981","A practical guide to the preparation of Ca2+ buffers.","8201981",136]
["1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","C025603","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,1,1996,"8939351","Excitation of Drosophila photoreceptors by BAPTA and ionomycin: evidence for capacitative Ca2+ entry?","8939351",136]
["1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid","C025603","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2004,"15254339","Calcium-mediated activation of c-Jun NH2-terminal kinase (JNK) and apoptosis in response to cadmium in murine macrophages.","15254339",136]
["1,2-bis(2-pyridyl)ethylene","1,2-bis(2-pyridyl)ethylene","C530364","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2008,"18441256","Relationship between GST Yp induction and hepatocyte proliferation in rats treated with phase II drug metabolizing enzyme inducers.","18441256",136]
["1,2-bis(3,5-dioxopiperazin-1-yl)ethane","1,2-bis(3,5-dioxopiperazin-1-yl)ethane","C000283","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,1994,"8012276","bis(2,6-dioxopiperaxine) derivatives, topoisomerase II inhibitors which do not form a DNA cleavable complex, induce thymocyte apoptosis.","8012276",136]
["1,2-bis(isothiazol-5-yl)disulfane","1,2-bis(isothiazol-5-yl)disulfane","C579148","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"23056207","Characterisation of a Tip60 specific inhibitor, NU9056, in prostate cancer.","23056207",136]
["1,2-bis(isothiazol-5-yl)disulfane","1,2-bis(isothiazol-5-yl)disulfane","C579148","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"23056207","Characterisation of a Tip60 specific inhibitor, NU9056, in prostate cancer.","23056207",136]
["1,2-bis(methylsulfonyl)-1--(2-chloroethyl)-2-((1-(4-nitrophenyl)ethoxy)carbonyl)hydrazine","1,2-bis(methylsulfonyl)-1--(2-chloroethyl)-2-((1-(4-nitrophenyl)ethoxy)carbonyl)hydrazine","C118156","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"22862779","Preliminary studies with a new hypoxia-selective cytotoxin, KS119W, in vitro and in vivo.","22862779",136]
["1,2-bis(octadeca-2,4-dienoyl)-glycero-3-phosphocholine","1,2-bis(octadeca-2,4-dienoyl)-glycero-3-phosphocholine","C102749","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1996,"8714718","Study on in vitro stability of polymerized liposomes.","8714718",136]
["1,2-bis-manephosphotidylcholine","1,2-bis-manephosphotidylcholine","C045294","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1985,"3995010","Aggregation, lipid exchange, and metastable phases of dimyristoylphosphatidylethanolamine vesicles.","3995010",136]
["1,2-cyclohexanediamine","1,2-cyclohexanediamine","C030435","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2006,"16386904","Anticancer activity of a series of platinum complexes integrating demethylcantharidin with isomers of 1,2-diaminocyclohexane.","16386904",136]
["1,2-cyclohexanediamine","1,2-cyclohexanediamine","C030435","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22247027","Synthesis, in vitro cytotoxicity, and interaction with DNA of platinum(II) complexes with N-monocycloalkyl derivatives of 1R,2R-diaminocyclohexane as carrier ligands.","22247027",136]
["1,2-cyclohexanediamine","1,2-cyclohexanediamine","C030435","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22561544","Antitumor platinum(II) complexes of N-monoalkyl-1R, 2R-diaminocyclohexane derivatives with alkyl groups as hindrance.","22561544",136]
["1,2-cyclohexanediamine","1,2-cyclohexanediamine","C030435","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2017,"28176540","Antitumoral activity of 1,2-diaminocyclohexane derivatives in breast, colon and skin human cancer cells.","28176540",136]
["1,2-cyclohexanediamine","1,2-cyclohexanediamine","C030435","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22561544","Antitumor platinum(II) complexes of N-monoalkyl-1R, 2R-diaminocyclohexane derivatives with alkyl groups as hindrance.","22561544",136]
["1,2-cyclohexanediamine","1,2-cyclohexanediamine","C030435","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"26099502","Synthesis, characterization and theoretical calculations of (1,2-diaminocyclohexane)(1,3-diaminopropane)gold(III) chloride complexes: in vitro cytotoxic evaluations against human cancer cell lines.","26099502",136]
["1,2-cyclohexanediamine","1,2-cyclohexanediamine","C030435","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28176540","Antitumoral activity of 1,2-diaminocyclohexane derivatives in breast, colon and skin human cancer cells.","28176540",136]
["1,2-cyclohexanediamine","1,2-cyclohexanediamine","C030435","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2005,"15760185","Shape-complementarity in the recognition of tricarboxylic acids by a [3+3] polyazacyclophane receptor.","15760185",136]
["1,2-cyclohexanediamine","1,2-cyclohexanediamine","C030435","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"17592835","Dinuclear platinum complexes with biological relevance based on the 1,2-diaminocyclohexane carrier ligand.","17592835",136]
["1,2-cyclohexanediol","1,2-cyclohexanediol","C064619","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2006,"16586103","Biocatalytic production of enantiopure cyclohexane-trans-1,2-diol using extracellular lipases from Bacillus subtilis.","16586103",136]
["1,2-cyclohexanediol","1,2-cyclohexanediol","C064619","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Nasal Mucosa","D009297","Nasal Mucosa",1,2,2012,"22711445","Assessment of the nuclear pore dilating agent trans-cyclohexane-1,2-diol in differentiated airway epithelium.","22711445",136]
["1,2-cyclohexanedione","1,2-cyclohexanedione","C018031","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1991,"1648914","Cyclohexanedione modification of arginine at the active site of Aspergillus ficuum phytase.","1648914",136]
["1,2-cyclohexanedione","1,2-cyclohexanedione","C018031","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1982,"6816842","Heat stability of milk: influence of modification of lysine and arginine on the heat stability-pH profile.","6816842",136]
["1,2-dehydro-N-acetyldopamine","1,2-dehydro-N-acetyldopamine","C053357","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2000,"10860558","Oxidation chemistry of 1,2-dehydro-N-acetyldopamines: direct evidence for the formation of 1,2-dehydro-N-acetyldopamine quinone.","10860558",136]
["1,2-dehydro-N-acetyldopamine","1,2-dehydro-N-acetyldopamine","C053357","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1992,"1316899","Evidence for the formation of a quinone methide during the oxidation of the insect cuticular sclerotizing precursor 1,2-dehydro-N-acetyldopamine.","1316899",136]
["1,2-dehydro-N-acetyldopamine","1,2-dehydro-N-acetyldopamine","C053357","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2017,"28228229","Oxidative transformation of a tunichrome model compound provides new insight into the crosslinking and defense reaction of tunichromes.","28228229",136]
["1,2-di(quinazolin-4-yl)diselane","1,2-di(quinazolin-4-yl)diselane","C000613607","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"25124615","Preliminary evaluation of the in vitro efficacy of 1, 2-di (quinazolin-4-yl) diselane against SiHa cervical cancer cells.","25124615",136]
["1,2-di(quinazolin-4-yl)diselane","1,2-di(quinazolin-4-yl)diselane","C000613607","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"25124615","Preliminary evaluation of the in vitro efficacy of 1, 2-di (quinazolin-4-yl) diselane against SiHa cervical cancer cells.","25124615",136]
["1,2-diacetoxy-6-methoxy-3,3,14-trimethyl-1,2,3,14-tetrahydro-7H-benzo(b)chromeno(6,5-g)(1,8)naphthyridin-7-one","1,2-diacetoxy-6-methoxy-3,3,14-trimethyl-1,2,3,14-tetrahydro-7H-benzo(b)chromeno(6,5-g)(1,8)naphthyridin-7-one","C000595867","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"25360689","Synthesis, antitumor activity, and mechanism of action of benzo[b]chromeno[6,5-g][1,8]naphthyridin-7-one analogs of acronycine.","25360689",136]
["1,2-diacetylbenzene","1,2-diacetylbenzene","C048792","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2007,"17654252","Environmental metabolite, 1,2-diacetylbenzene, produces cytotoxicity through ROS generation in HUVEC cells.","17654252",136]
["1,2-diacetylbenzene","1,2-diacetylbenzene","C048792","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2008,"18063464","Cytotoxicity of 1,2-diacetylbenzene in human neuroblastoma SHSY5Y cells is mediated by oxidative stress.","18063464",136]
["1,2-diacetylbenzene","1,2-diacetylbenzene","C048792","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,2,2014,"24373906","Olfactory mucosal necrosis in rats following acute intraperitoneal administration of 1,2-diethylbenzene, 1,2-diacetylbenzene and 2,5-hexanedione.","24373906",136]
["1,2-diacylglycerol","1,2-diacylglycerol","C011439","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2002,"12106819","Advanced glycation end-products induce apoptosis of bovine retinal pericytes in culture: involvement of diacylglycerol/ceramide production and oxidative stress induction.","12106819",136]
["1,2-diacylglycerol","1,2-diacylglycerol","C011439","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2009,"19379015","Conformationally constrained analogues of diacylglycerol (DAG). 31. Modulation of the biological properties of diacylgycerol lactones (DAG-lactones) containing rigid-rod acyl groups separated from the core lactone by spacer units of different lengths.","19379015",136]
["1,2-diacylglycerol","1,2-diacylglycerol","C011439","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22265739","Impact of DAG stimulation on mineral synthesis, mineral structure and osteogenic differentiation of human cord blood stem cells.","22265739",136]
["1,2-diacylglycerol","1,2-diacylglycerol","C011439","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2005,"16274459","The EP3 receptor stimulates ceramide and diacylglycerol release and inhibits growth of primary keratinocytes.","16274459",136]
["1,2-diacylglycerol","1,2-diacylglycerol","C011439","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"19628710","CalDAG-GEFI is at the nexus of calcium-dependent platelet activation.","19628710",136]
["1,2-diacylglycerol","1,2-diacylglycerol","C011439","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2004,"14733489","Kinetics of diglyceride formation and isomerization in virgin olive oils by employing 31P NMR spectroscopy. Formulation of a quantitative measure to assess olive oil storage history.","14733489",136]
["1,2-diacylglycerol","1,2-diacylglycerol","C011439","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2008,"18828790","In vitro effects of phosphatidylcholine and transgalactooligosaccharides on the production of 1,2-sn-diacylglycerol by Bifidobacterium longum biovar infantis.","18828790",136]
["1,2-diacylglycerol","1,2-diacylglycerol","C011439","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,3,2009,"19447192","Continuous measurement of galactolipid hydrolysis by pancreatic lipolytic enzymes using the pH-stat technique and a medium chain monogalactosyl diglyceride as substrate.","19447192",136]
["1,2-diacylglycerol","1,2-diacylglycerol","C011439","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1990,"2167919","sn-1,2-diacylglycerol levels increase in progesterone-stimulated Xenopus laevis oocytes.","2167919",136]
["1,2-diacylglycerol","1,2-diacylglycerol","C011439","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2013,"23266086","Diacylglycerol kinase θ: regulation and stability.","23266086",136]
["1,2-diacylglycerol","1,2-diacylglycerol","C011439","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"24907585","Cationic vesicles based on biocompatible diacyl glycerol-arginine surfactants: physicochemical properties, antimicrobial activity, encapsulation efficiency and drug release.","24907585",136]
["1,2-diacylglycerol","1,2-diacylglycerol","C011439","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2016,"26720174","Effect of Acylglycerol Composition and Fatty Acyl Chain Length on Lipid Digestion in pH-Stat Digestion Model and Simulated In Vitro Digestion Model.","26720174",136]
["1,2-diacylglycerol","1,2-diacylglycerol","C011439","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1986,"3009501","1,2-Diacylglycerols mimic phorbol 12-myristate 13-acetate activation of the sea urchin egg.","3009501",136]
["1,2-diacylglycerol","1,2-diacylglycerol","C011439","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1994,"8141783","Alkalosis- and ATP-induced increases in the diacyglycerol pool in alveolar type II cells are derived from phosphatidylcholine and phosphatidylinositol.","8141783",136]
["1,2-diacylglycerol","1,2-diacylglycerol","C011439","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,1988,"3185097","Increased 1,2-diacylglycerol content in myopathic hamster hearts at a prenecrotic stage.","3185097",136]
["1,2-diacylglycerol","1,2-diacylglycerol","C011439","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Olfactory Mucosa","D009831","Olfactory Mucosa",1,1,2014,"24489954","Phospholipase C and diacylglycerol mediate olfactory responses to amino acids in the main olfactory epithelium of an amphibian.","24489954",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C1923,B1923)","v":"1,2-diamino-4,5-methylenedioxybenzene"},"1,2-diamino-4,5-methylenedioxybenzene","C058886","1_MIE",867,1,"Intracellular pH","Decrease",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J1923,K1923)","v":"Hydrogen-Ion Concentration"},"D006863","Hydrogen-Ion Concentration",2,2,2000,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q1923,Q1923)","v":"11117328"},"Acid-base properties of the reaction product of sialic acid with fluorogenic reagent, 1,2-diamino-4,5-methylenedioxybenzene (DMB).","11117328",136]
["1,2-diaminoanthraquinone","1,2-diaminoanthraquinone","C118201","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"25127132","A novel compound NSC745885 exerts an anti-tumor effect on tongue cancer SAS cells in vitro and in vivo.","25127132",136]
["1,2-diaminoanthraquinone","1,2-diaminoanthraquinone","C118201","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"25127132","A novel compound NSC745885 exerts an anti-tumor effect on tongue cancer SAS cells in vitro and in vivo.","25127132",136]
["1,2-diaminobenzene","1,2-diaminobenzene","C034193","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2001,"11771327","[Inhibition of peroxidase oxidation of 3,3',5,5'-tetramethylbenzidine and o-phenylenediamine by 1-amino-2-naphthol-4-sulfonic acid and its polysulfide].","11771327",136]
["1,2-diaminobenzene","1,2-diaminobenzene","C034193","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2002,"11908604","Extension of the color suite available for chemical enhancement of fingerprints in blood.","11908604",136]
["1,2-diaminobenzene","1,2-diaminobenzene","C034193","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2003,"12586140","Effect of o-phenylenediamine on Cu adsorption and desorption in red soil and its uptake by paddy rice (Oryza sativa).","12586140",136]
["1,2-diaminobenzene","1,2-diaminobenzene","C034193","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2003,"12658992","[Noncompetitive activation of peroxidase oxidation of o-phenylenediamine by melamine].","12658992",136]
["1,2-diaminobenzene","1,2-diaminobenzene","C034193","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2003,"12737484","Electroanalytical and spectroscopic characterization of poly(o-phenylenediamine) grown on highly oriented pyrolytic graphite.","12737484",136]
["1,2-diaminobenzene","1,2-diaminobenzene","C034193","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1965,"14346090","REMOVAL OF THE N-TERMINAL RESIDUE OF A PROTEIN AFTER TRANSAMINATION.","14346090",136]
["1,2-diaminobenzene","1,2-diaminobenzene","C034193","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1992,"1492391","[Use of o-phenylenediamine in determining the activity of L-lysine- alpha-oxidase and concentration of L-lysine].","1492391",136]
["1,2-diaminobenzene","1,2-diaminobenzene","C034193","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"16859972","Kinetic spectrophotometric method for o-phenylenediamine in the presence of gold(III).","16859972",136]
["1,2-diaminobenzene","1,2-diaminobenzene","C034193","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2010,"19783226","A mediated polyphenol oxidase biosensor immobilized by electropolymerization of 1,2-diamino benzene.","19783226",136]
["1,2-diaminobenzene","1,2-diaminobenzene","C034193","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2010,"20692226","Spectrophotometric quantification of horseradish peroxidase with o-phenylenediamine.","20692226",136]
["1,2-diaminobenzene","1,2-diaminobenzene","C034193","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"21877155","Studies on molecular structure and tautomerism of a vitamin B6 analog with density functional theory.","21877155",136]
["1,2-diaminobenzene","1,2-diaminobenzene","C034193","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"22265528","Evaluation of seven cosubstrates in the quantification of horseradish peroxidase enzyme by square wave voltammetry.","22265528",136]
["1,2-diaminocyclohexaneplatinum II citrate","1,2-diaminocyclohexaneplatinum II citrate","C044245","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"26810463","Polymer nanoparticle delivery of dichloroacetate and DACH-Pt to enhance antitumor efficacy and lower systemic toxicity.","26810463",136]
["1,2-diaminocyclohexyl platinum sulfate","1,2-diaminocyclohexyl platinum sulfate","C024236","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"25263685","PEGylated dendritic diaminocyclohexyl-platinum (II) conjugates as pH-responsive drug delivery vehicles with enhanced tumor accumulation and antitumor efficacy.","25263685",136]
["1,2-diaminocyclohexyl platinum sulfate","1,2-diaminocyclohexyl platinum sulfate","C024236","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"25263685","PEGylated dendritic diaminocyclohexyl-platinum (II) conjugates as pH-responsive drug delivery vehicles with enhanced tumor accumulation and antitumor efficacy.","25263685",136]
["1,2-dianilinoethane","1,2-dianilinoethane","C007305","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1985,"3003137","High-performance liquid chromatography of plasma catecholamines using 1,2-diphenylethylenediamine as precolumn fluorescence derivatization reagent.","3003137",136]
["1,2-diarachidonoyl-glycero-3-phosphoethanolamine","1,2-diarachidonoyl-glycero-3-phosphoethanolamine","C044820","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"26588871","Diarachidonoylphosphoethanolamine induces apoptosis of malignant pleural mesothelioma cells through a Trx/ASK1/p38 MAPK pathway.","26588871",136]
["1,2-diarachidonoyl-glycero-3-phosphoethanolamine","1,2-diarachidonoyl-glycero-3-phosphoethanolamine","C044820","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2015,"26004138","Diarachidonoylphosphoethanolamine induces necrosis/necroptosis of malignant pleural mesothelioma cells.","26004138",136]
["1,2-dibromo-2,4-dicyanobutane","1,2-dibromo-2,4-dicyanobutane","C039411","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2008,"18759875","Proliferative responses in the local lymph node assay associated with concomitant exposure to 1,4-phenylenediamine and methyldibromo glutaronitrile: evidence for synergy?","18759875",136]
["1,2-dibromo-3-chloropropane","1,2-dibromo-3-chloropropane","C007318","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2003,"12759094","Dibromochloropropane inhibits spermatogonial development in rats.","12759094",136]
["1,2-dibromo-3-chloropropane","1,2-dibromo-3-chloropropane","C007318","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,1998,"9733282","Single-strand breaks, cell cycle arrest and apoptosis in HL-60 and LLCPK1 cells exposed to 1,2-dibromo-3-chloropropane.","9733282",136]
["1,2-dibromo-3-chloropropane","1,2-dibromo-3-chloropropane","C007318","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Atrophy","D001284","Atrophy",1,1,1991,"1908144","Prevention of 1,2-dibromo-3-chloropropane (DBCP)-induced kidney necrosis and testicular atrophy by 3-aminobenzamide.","1908144",136]
["1,2-dibromo-3-chloropropane","1,2-dibromo-3-chloropropane","C007318","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Atrophy","D001284","Atrophy",1,1,1990,"2124613","Determinants of spermatogenesis recovery among workers exposed to 1,2-dibromo-3-chloropropane.","2124613",136]
["1,2-dibromo-3-chloropropane","1,2-dibromo-3-chloropropane","C007318","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Atrophy","D001284","Atrophy",1,1,1982,"7153065","Toxicity of 1,2-dibromo-3-chloropropane (DBCP). I. Histopathological examination of male rats exposed to DBCP vapour.","7153065",136]
["1,2-dibromo-3-chloropropane","1,2-dibromo-3-chloropropane","C007318","7_AO",872,7,"Site of Contact Nasal Tumors","Increase","Nasal Cavity","D009296","Nasal Cavity",1,2,1980,"7016076","Respiratory pathology in rats and mice after inhalation of 1,2-dibromo-3-chloropropane or 1,2 dibromoethane for 13 weeks.","7016076",136]
["1,2-dibromo-3-chloropropane","1,2-dibromo-3-chloropropane","C007318","7_AO",872,7,"Site of Contact Nasal Tumors","Increase","Nasal Cavity","D009296","Nasal Cavity",1,1,1980,"7451555","Morphology and sex-dependent manifestation of nasal tumors in B6C3F1 mice after chronic inhalation of 1,2-dibromo-3-chloropropane.","7451555",136]
["1,2-dibromo-3-chloropropane","1,2-dibromo-3-chloropropane","C007318","7_AO",872,7,"Site of Contact Nasal Tumors","Increase","Nasal Cavity","D009296","Nasal Cavity",1,1,1980,"7459212","Morphology of nasal-cavity tumours in rats after chronic inhalation of 1,2-dibromo-3-chloropropane.","7459212",136]
["1,2-dibromo-3-chloropropane","1,2-dibromo-3-chloropropane","C007318","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,1991,"1908144","Prevention of 1,2-dibromo-3-chloropropane (DBCP)-induced kidney necrosis and testicular atrophy by 3-aminobenzamide.","1908144",136]
["1,2-dibromo-3-chloropropane","1,2-dibromo-3-chloropropane","C007318","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,2,1989,"2734806","Role of P-450 activity and glutathione levels in 1,2-dibromo-3-chloropropane tissue distribution, renal necrosis and in vivo DNA damage.","2734806",136]
["1,2-dibromo-3-chloropropane","1,2-dibromo-3-chloropropane","C007318","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,1991,"2069019","Testicular metabolism and toxicity of halogenated propanes.","2069019",136]
["1,2-dibromo-3-chloropropane","1,2-dibromo-3-chloropropane","C007318","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,1988,"3400095","Testicular necrosis and DNA damage caused by deuterated and methylated analogs of 1,2-dibromo-3-chloropropane in the rat.","3400095",136]
["1,2-dibromo-3-chloropropane","1,2-dibromo-3-chloropropane","C007318","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,1987,"3424370","Renal necrosis and DNA damage caused by selectively deuterated and methylated analogs of 1,2-dibromo-3-chloropropane in the rat.","3424370",136]
["1,2-dibromo-3-chloropropane","1,2-dibromo-3-chloropropane","C007318","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,2,1985,"4049407","Initial and residual toxicity following acute exposure of developing male rats to dibromochloropropane.","4049407",136]
["1,2-dibromo-3-chloropropane","1,2-dibromo-3-chloropropane","C007318","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,1982,"7153065","Toxicity of 1,2-dibromo-3-chloropropane (DBCP). I. Histopathological examination of male rats exposed to DBCP vapour.","7153065",136]
["1,2-dibromo-3-chloropropane","1,2-dibromo-3-chloropropane","C007318","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,1995,"7495641","Comparative toxicity of (+)-(R)- and (-)-(S)-1,2-dibromo-3-chloropropane.","7495641",136]
["1,2-dibromo-3-chloropropane","1,2-dibromo-3-chloropropane","C007318","7_AO",872,7,"Site of Contact Nasal Tumors","Increase","Nose Neoplasms","D009669","Nose Neoplasms",1,3,1980,"7451555","Morphology and sex-dependent manifestation of nasal tumors in B6C3F1 mice after chronic inhalation of 1,2-dibromo-3-chloropropane.","7451555",136]
["1,2-dibromo-3-chloropropane","1,2-dibromo-3-chloropropane","C007318","7_AO",872,7,"Site of Contact Nasal Tumors","Increase","Nose Neoplasms","D009669","Nose Neoplasms",1,3,1980,"7459212","Morphology of nasal-cavity tumours in rats after chronic inhalation of 1,2-dibromo-3-chloropropane.","7459212",136]
["1,2-dibromobenzene","1,2-dibromobenzene","C102879","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,1996,"8821673","Comparison of hepatotoxicity of 1,2-, 1,3- and 1,4-dibromobenzenes: the dynamics of changes of selected parameters of liver necrosis in acute poisoning in mice.","8821673",136]
["1,2-dibromobenzene","1,2-dibromobenzene","C102879","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,1998,"9456081","Hepatotoxicity of brominated benzenes: relationship between chemical structure and hepatotoxic effects in acute intoxication of mice.","9456081",136]
["1,2-dichloro-4-nitrobenzene","1,2-dichloro-4-nitrobenzene","C028328","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1965,"14342229","AN ENZYME CATALYSING THE CONJUGATION OF EPOXIDES WITH GLUTATHIONE.","14342229",136]
["1,2-dichloroethylene","1,2-dichloroethylene","C035384","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2010,"20042217","Aerobic biodegradation of cis-1,2-dichloroethene as sole carbon source: Stable carbon isotope fractionation and growth characteristics.","20042217",136]
["1,2-dichloroethylene","1,2-dichloroethylene","C035384","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,1,2004,"15347647","Active site engineering of the epoxide hydrolase from Agrobacterium radiobacter AD1 to enhance aerobic mineralization of cis-1,2-dichloroethylene in cells expressing an evolved toluene ortho-monooxygenase.","15347647",136]
["1,2-didecanoylphosphatidylcholine","1,2-didecanoylphosphatidylcholine","C015132","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Nasal Mucosa","D009297","Nasal Mucosa",1,1,1994,"7891298","Epithelial transport and bioavailability of intranasally administered human growth hormone formulated with the absorption enhancers didecanoyl-L-alpha-phosphatidylcholine and alpha-cyclodextrin in rabbits.","7891298",136]
["1,2-didecanoylphosphatidylcholine","1,2-didecanoylphosphatidylcholine","C015132","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Nasal Mucosa","D009297","Nasal Mucosa",1,2,1993,"8513970","Transport of insulin across rabbit nasal mucosa in vitro induced by didecanoyl-L-alpha-phosphatidylcholine.","8513970",136]
["1,2-didecanoylphosphatidylcholine","1,2-didecanoylphosphatidylcholine","C015132","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Nasal Mucosa","D009297","Nasal Mucosa",1,2,1996,"8897913","Effects of a short-chain phospholipid on ion transport pathways in rabbit nasal airway epithelium.","8897913",136]
["1,2-didecanoylphosphatidylcholine","1,2-didecanoylphosphatidylcholine","C015132","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Nasal Mucosa","D009297","Nasal Mucosa",1,1,1997,"9311625","Absorption and metabolism of the absorption enhancer didecanoylphosphatidylcholine in rabbit nasal epithelium in vivo.","9311625",136]
["1,2-didodecanoyl-glycero-3-phosphocholine","1,2-didodecanoyl-glycero-3-phosphocholine","C054349","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1989,"2730878","Interactions of colicin A domains with phospholipid monolayers and liposomes: relevance to the mechanism of action.","2730878",136]
["1,2-dielaidoylphosphatidylethanolamine","1,2-dielaidoylphosphatidylethanolamine","C020888","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2003,"12561428","[Apoptotic effect of bcl-XL antisense oligodeoxynucleotide mediated by lipofectin on cell strain CNE-2Z].","12561428",136]
["1,2-dielaidoylphosphatidylethanolamine","1,2-dielaidoylphosphatidylethanolamine","C020888","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2003,"14668052","Toxicogenomics of non-viral vectors for gene therapy: a microarray study of lipofectin- and oligofectamine-induced gene expression changes in human epithelial cells.","14668052",136]
["1,2-dielaidoylphosphatidylethanolamine","1,2-dielaidoylphosphatidylethanolamine","C020888","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1999,"10563787","Synthesis and characterization of NVOC-DOPE, a caged photoactivatable derivative of dioleoylphosphatidylethanolamine.","10563787",136]
["1,2-dielaidoylphosphatidylethanolamine","1,2-dielaidoylphosphatidylethanolamine","C020888","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2001,"11159404","Phase behavior and aggregate structure in mixtures of dioleoylphosphatidylethanolamine and poly(ethylene glycol)-lipids.","11159404",136]
["1,2-dielaidoylphosphatidylethanolamine","1,2-dielaidoylphosphatidylethanolamine","C020888","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1992,"1326418","The chemical synthesis of N-[1-(2-naphthol)]-phosphatidylethanolamine, a fluorescent phospholipid for excited-state proton transfer studies.","1326418",136]
["1,2-dielaidoylphosphatidylethanolamine","1,2-dielaidoylphosphatidylethanolamine","C020888","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1992,"1621969","Trypsin-induced lysis of lipid vesicles: effect of surface charge and lipid composition.","1621969",136]
["1,2-dielaidoylphosphatidylethanolamine","1,2-dielaidoylphosphatidylethanolamine","C020888","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2008,"18408871","Enhanced depigmenting effects of N-glycosylation inhibitors delivered by pH-sensitive liposomes into HM3KO melanoma cells.","18408871",136]
["1,2-dielaidoylphosphatidylethanolamine","1,2-dielaidoylphosphatidylethanolamine","C020888","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2011,"20932963","New pH-sensitive liposomes containing phosphatidylethanolamine and a bacterial dirhamnolipid.","20932963",136]
["1,2-dielaidoylphosphatidylethanolamine","1,2-dielaidoylphosphatidylethanolamine","C020888","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1989,"2590671","Cross-linking of phosphatidylethanolamine neighbors with dimethylsuberimidate is sensitive to the lipid phase.","2590671",136]
["1,2-dielaidoylphosphatidylethanolamine","1,2-dielaidoylphosphatidylethanolamine","C020888","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1988,"3128327","beta-Galactosidase-induced destabilization of liposome composed of phosphatidylethanolamine and ganglioside GM1.","3128327",136]
["1,2-dielaidoylphosphatidylethanolamine","1,2-dielaidoylphosphatidylethanolamine","C020888","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1986,"3741846","Fusion of phosphatidylethanolamine-containing liposomes and mechanism of the L alpha-HII phase transition.","3741846",136]
["1,2-dielaidoylphosphatidylethanolamine","1,2-dielaidoylphosphatidylethanolamine","C020888","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1986,"3778935","Biodistribution of pH-sensitive immunoliposomes.","3778935",136]
["1,2-dielaidoylphosphatidylethanolamine","1,2-dielaidoylphosphatidylethanolamine","C020888","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1987,"3802078","Cytotoxicity of diphtheria toxin A fragment to toxin-resistant murine cells delivered by pH-sensitive immunoliposomes.","3802078",136]
["1,2-dielaidoylphosphatidylethanolamine","1,2-dielaidoylphosphatidylethanolamine","C020888","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1986,"3814129","Trypsin induced destabilization of liposomes composed of dioleoylphosphatidylethanolamine and glycophorin.","3814129",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C1987,B1987)","v":"1,2-dielaidoylphosphatidylethanolamine"},"1,2-dielaidoylphosphatidylethanolamine","C020888","1_MIE",867,1,"Intracellular pH","Decrease",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J1987,K1987)","v":"Hydrogen-Ion Concentration"},"D006863","Hydrogen-Ion Concentration",2,2,1996,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q1987,Q1987)","v":"8690067"},"Liposomes with detachable polymer coating: destabilization and fusion of dioleoylphosphatidylethanolamine vesicles triggered by cleavage of surface-grafted poly(ethylene glycol).","8690067",136]
["1,2-dielaidoylphosphatidylethanolamine","1,2-dielaidoylphosphatidylethanolamine","C020888","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1996,"8794759","Effect of liposomal composition on photoactivated liposome fusion.","8794759",136]
["1,2-dielaidoylphosphatidylethanolamine","1,2-dielaidoylphosphatidylethanolamine","C020888","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Nasal Mucosa","D009297","Nasal Mucosa",1,1,1999,"9886393","Intranasal immunization with plasmid DNA-lipid complexes elicits mucosal immunity in the female genital and rectal tracts.","9886393",136]
["1,2-diethylbenzene","1,2-diethylbenzene","C064750","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,2,2014,"24373906","Olfactory mucosal necrosis in rats following acute intraperitoneal administration of 1,2-diethylbenzene, 1,2-diacetylbenzene and 2,5-hexanedione.","24373906",136]
["1,2-diformylhydrazine","1,2-diformylhydrazine","C017224","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2002,"12110983","Diformylhydrazine as analytical reagent for spectrophotometric determination of iron(II) and iron(III).","12110983",136]
["1,2-dihexadecyl-3-O-octadecenoyl-sn-glycerol","1,2-dihexadecyl-3-O-octadecenoyl-sn-glycerol","C038662","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1983,"6860702","Deacylation and uptake of the fatty acyl chain from enantiomeric dialkylacylglycerol by intact rat fat cells.","6860702",136]
["1,2-dihexadecyl-sn-glycero-3-phosphocholine","1,2-dihexadecyl-sn-glycero-3-phosphocholine","C052298","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1999,"10512821","Low pH induces an interdigitated gel to bilayer gel phase transition in dihexadecylphosphatidylcholine membrane.","10512821",136]
["1,2-dihexadecyl-sn-glycero-3-phosphocholine","1,2-dihexadecyl-sn-glycero-3-phosphocholine","C052298","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1998,"9835045","Characterization of magnetically oriented phospholipid micelles for measurement of dipolar couplings in macromolecules.","9835045",136]
["1,2-dihexadecyl-sn-glycero-3-phosphocholine","1,2-dihexadecyl-sn-glycero-3-phosphocholine","C052298","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1998,"9835051","Improved dilute bicelle solutions for high-resolution NMR of biological macromolecules.","9835051",136]
["1,2-dihexanoylphosphatidylethanolamine","1,2-dihexanoylphosphatidylethanolamine","C048072","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2013,"23462644","The hydrophobic substituent in aminophospholipids affects the formation kinetics of their Schiff bases.","23462644",136]
["1,2-dihexanoylphosphatidylethanolamine","1,2-dihexanoylphosphatidylethanolamine","C048072","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1986,"3948291","Dihexanoylphosphatidylethanolamine: effect of head group charge on rates of alkaline and phospholipase A2 catalyzed hydrolyses.","3948291",136]
["1,2-dihexanoyl-sn-glycero-3-phosphorylcholine","1,2-dihexanoyl-sn-glycero-3-phosphorylcholine","C092445","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1998,"9548962","General base catalysis by the phosphatidylcholine-preferring phospholipase C from Bacillus cereus: the role of Glu4 and Asp55.","9548962",136]
["1,2-dihydro-1,8,10-trihydroxy-2-(2-hydroxypropan-2-yl)-9-(3-methylbut-2-enyl)furo(3,2-a)xanthen-11-one","1,2-dihydro-1,8,10-trihydroxy-2-(2-hydroxypropan-2-yl)-9-(3-methylbut-2-enyl)furo(3,2-a)xanthen-11-one","C530094","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2008,"17991497","Xanthones with quinone reductase-inducing activity from the fruits of Garcinia mangostana (Mangosteen).","17991497",136]
["1,2-dihydro-5-(1H-indol-2-yl)-1,2,4-triazole-3-thione","1,2-dihydro-5-(1H-indol-2-yl)-1,2,4-triazole-3-thione","C586652","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"27688190","Design, selective alkylation and X-ray crystal structure determination of dihydro-indolyl-1,2,4-triazole-3-thione and its 3-benzylsulfanyl analogue as potent anticancer agents.","27688190",136]
["1,2-dimyristoylphosphatidylethanolamine","1,2-dimyristoylphosphatidylethanolamine","C018525","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1989,"2590671","Cross-linking of phosphatidylethanolamine neighbors with dimethylsuberimidate is sensitive to the lipid phase.","2590671",136]
["1,2-Dipalmitoylphosphatidylcholine","1,2-Dipalmitoylphosphatidylcholine","D015060","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1986,"3955037","Lytic effects of melittin and delta-haemolysin from Staphylococcus aureus on vesicles of dipalmitoylphosphatidylcholine.","3955037",136]
["1,3-benzodioxole","1,3-benzodioxole","C040539","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,1997,"9463524","The prevention of ferric nitrilotriacetate-induced nephro- and hepatotoxicity by methylenedioxybenzene antioxidants.","9463524",136]
["1,3-dichloro-2-propanol","1,3-dichloro-2-propanol","C033489","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"21956155","Complete detoxification of tris(1,3-dichloro-2-propyl) phosphate by mixed two bacteria, Sphingobium sp. strain TCM1 and Arthrobacter sp. strain PY1.","21956155",136]
["1,4,7-triazacyclononane-N,N',N''-triacetic acid","1,4,7-triazacyclononane-N,N',N''-triacetic acid","C048993","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2011,"21617974","One-step radiosynthesis of ¹⁸F-AlF-NOTA-RGD₂ for tumor angiogenesis PET imaging.","21617974",136]
["1,5-anhydro-6-deoxymethanesulfamidoglucitol","1,5-anhydro-6-deoxymethanesulfamidoglucitol","C000596776","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25557509","A novel carbohydrate derived compound FCP5 causes DNA strand breaks and oxidative modifications of DNA bases in cancer cells.","25557509",136]
["10'(Z),13'(E),15'(E)-heptadecatrienylhydroquinone","10'(Z),13'(E),15'(E)-heptadecatrienylhydroquinone","C471674","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"23088786","A cysteine-reactive alkyl hydroquinone modifies topoisomerase IIα, enhances DNA breakage, and induces apoptosis in cancer cells.","23088786",136]
["11,11'-dideoxyverticilin","11,11'-dideoxyverticilin","C490191","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2005,"15846117","11,11'-dideoxy-verticillin: a natural compound possessing growth factor receptor tyrosine kinase-inhibitory effect with anti-tumor activity.","15846117",136]
["11-keto-boswellic acid","11-keto-boswellic acid","C447943","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21821018","Potentiation of the antitumor effect of 11-keto-β-boswellic acid by its 3-α-hexanoyloxy derivative.","21821018",136]
["14-O-phosphonooxymethyltriptolide","14-O-phosphonooxymethyltriptolide","C579022","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"24143232","Minnelide: a novel therapeutic that promotes apoptosis in non-small cell lung carcinoma in vivo.","24143232",136]
["15-deoxyprostaglandin J2","15-deoxyprostaglandin J2","C477819","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2011,"21999315","Induction of apoptosis in non-small cell lung carcinoma A549 cells by PGD₂ metabolite, 15d-PGJ₂.","21999315",136]
["17-(dimethylaminoethylamino)-17-demethoxygeldanamycin","17-(dimethylaminoethylamino)-17-demethoxygeldanamycin","C448659","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"20111068","Phase I study of the heat shock protein 90 inhibitor alvespimycin (KOS-1022, 17-DMAG) administered intravenously twice weekly to patients with acute myeloid leukemia.","20111068",136]
["17-hydroxyjolkinolide B","17-hydroxyjolkinolide B","C057916","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2009,"19706767","17-hydroxy-jolkinolide B inhibits signal transducers and activators of transcription 3 signaling by covalently cross-linking Janus kinases and induces apoptosis of human cancer cells.","19706767",136]
["1-anilino-8-naphthalenesulfonate","1-anilino-8-naphthalenesulfonate","C027132","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1998,"9681870","Distinct stability of recombinant L and H subunits of human ferritin: calorimetric and ANS binding studies.","9681870",136]
["1-Deoxynojirimycin","1-Deoxynojirimycin","D017485","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Nasal Mucosa","D009297","Nasal Mucosa",1,2,2013,"22771076","Miglustat effects on the basal nasal potential differences in cystic fibrosis.","22771076",136]
["1H-indole-3-ethylene-5-nitrosalicylaldimine","1H-indole-3-ethylene-5-nitrosalicylaldimine","C582765","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"23090023","Acute toxicity and gastroprotective effect of the Schiff base ligand ¹H-indole-3-ethylene-5-nitrosalicylaldimine and its nickel (II) complex on ethanol induced gastric lesions in rats.","23090023",136]
["1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine","1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine","D015632","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"20951784","Protective effect of panaxatriol saponins extracted from Panax notoginseng against MPTP-induced neurotoxicity in vivo.","20951784",136]
["1-Methyl-4-phenylpyridinium","1-Methyl-4-phenylpyridinium","D015655","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27432061","Echinacoside Protects Against MPP(+)-Induced Neuronal Apoptosis via ROS/ATF3/CHOP Pathway Regulation.","27432061",136]
["1-naphthaleneacetic acid","1-naphthaleneacetic acid","C034182","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"17074416","A shift in sensitivity to auxin within development of maize seedlings.","17074416",136]
["1-Octanol","1-Octanol","D020003","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"17540545","Comparison between immobilized artificial membrane (IAM) HPLC data and lipophilicity in n-octanol for quinolone antibacterial agents.","17540545",136]
["1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea","1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea","C581572","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28522175","Pharmacological inhibition of soluble epoxide hydrolase or genetic deletion reduces diclofenac-induced gastric ulcers.","28522175",136]
["2-(2-(5-carboxy)oxazole)-5-hydroxy-6-aminobenzofuran-N,N,O-triacetic acid","2-(2-(5-carboxy)oxazole)-5-hydroxy-6-aminobenzofuran-N,N,O-triacetic acid","C058776","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1994,"7854327","Determination of cytosolic Mg2+ activity and buffering in BC3H-1 cells with mag-fura-2.","7854327",136]
["2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol","2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol","C529054","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25927597","Effect of Sodium-Glucose Cotransport Inhibition on Polycystic Kidney Disease Progression in PCK Rats.","25927597",136]
["2-(3'-methoxyphenyl)-6-pyrrolidinyl-4-quinazolinone","2-(3'-methoxyphenyl)-6-pyrrolidinyl-4-quinazolinone","C416653","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23523585","Newly synthesized quinazolinone HMJ-38 suppresses angiogenetic responses and triggers human umbilical vein endothelial cell apoptosis through p53-modulated Fas/death receptor signaling.","23523585",136]
["2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one","2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one","C085911","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2005,"15964304","MAPK and PI3K inhibition reduces proliferation of Barrett's adenocarcinoma in vitro.","15964304",136]
["2-(5-bromo-2-pyridylazo)-5-(N-propyl-N-sulfopropylamino)aniline","2-(5-bromo-2-pyridylazo)-5-(N-propyl-N-sulfopropylamino)aniline","C062965","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1989,"2486310","A sensitive, direct colorimetric assay of serum copper using 5-Br-PSAA.","2486310",136]
["2,2,5,5-tetramethyl-1-pyrrolidinyloxy-3-carboxylic acid","2,2,5,5-tetramethyl-1-pyrrolidinyloxy-3-carboxylic acid","C032289","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1998,"9615409","Magnetic relaxation dispersion of 7Li. II. Complex formation with nitroxides in the aqueous phase.","9615409",136]
["2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid","2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid","C002502","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2004,"15129740","Endogenous and dietary indoles: a class of antioxidants and radical scavengers in the ABTS assay.","15129740",136]
["2,2'-Dipyridyl","2,2'-Dipyridyl","D015082","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2002,"12002595","Potential-resolved electrochemiluminescence of ru(bpy)3(2+)/C2O4(2-) system on gold electrode.","12002595",136]
["2,3-bis(3'-hydroxybenzyl)butyrolactone","2,3-bis(3'-hydroxybenzyl)butyrolactone","C029497","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2003,"12663299","Whole-grain rye and wheat foods and markers of bowel health in overweight middle-aged men.","12663299",136]
["2,3-Diphosphoglycerate","2,3-Diphosphoglycerate","D019794","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1983,"6235012","[Pharmacological study on the effect of Panax ginseng on 2,3-diphosphoglycerate in the red cell].","6235012",136]
["2,4,3',5'-tetramethoxystilbene","2,4,3',5'-tetramethoxystilbene","C440850","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2008,"18816901","Induction of p27(kip1) by 2,4,3',5'- tetramethoxystilbene is regulated by protein phosphatase 2A-dependent Akt dephosphorylation in PC-3 prostate cancer cells.","18816901",136]
["2,4-bis(p-hydroxyphenyl)-2-butenal","2,4-bis(p-hydroxyphenyl)-2-butenal","C580808","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23082969","(E)-2,4-bis(p-hydroxyphenyl)-2-butenal has an antiproliferative effect on NSCLC cells induced by p38 MAPK-mediated suppression of NF-κB and up-regulation of TNFRSF10B (DR5).","23082969",136]
["2,4-dihydroxypyridine","2,4-dihydroxypyridine","C039659","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"25048739","Collective synthesis of 4-hydroxy-2-pyridone alkaloids and their antiproliferation activities.","25048739",136]
["2,4-Dinitrophenol","2,4-Dinitrophenol","D019297","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1996,"8703973","H+, K+, and Na+ transport across phospholipid vesicular membrane by the combined action of proton uncoupler 2,4-dinitrophenol and valinomycin.","8703973",136]
["2,5-hexanedione","2,5-hexanedione","C011269","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25739802","2,5-hexanedione induced apoptosis in mesenchymal stem cells from rat bone marrow via mitochondria-dependent caspase-3 pathway.","25739802",136]
["200B compound","200B compound","C588321","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2014,"24150799","Selective TBK1/IKKi dual inhibitors with anticancer potency.","24150799",136]
["25-hydroxycholesterol","25-hydroxycholesterol","C007997","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2009,"19250336","25-hydroxycholesterol provokes oligodendrocyte cell line apoptosis and stimulates the secreted phospholipase A2 type IIA via LXR beta and PXR.","19250336",136]
["25-hydroxyvitamin D","25-hydroxyvitamin D","C104450","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25905635","1α,25-Dihydroxyvitamin D3 Induces Neutrophil Apoptosis through the p38 MAPK Signaling Pathway in Chronic Obstructive Pulmonary Disease Patients.","25905635",136]
["2-amino-3-cyano-7-(dimethylamino)-4-(3-methoxy-4,5-methylenedioxyphenyl)-4H-chromene","2-amino-3-cyano-7-(dimethylamino)-4-(3-methoxy-4,5-methylenedioxyphenyl)-4H-chromene","C494722","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"21565459","Concomitant activation of caspase-9 and down-regulation of IAP proteins as a mechanism of apoptotic death in HepG2, T47D and HCT-116 cells upon exposure to a derivative from 4-aryl-4H-chromenes family.","21565459",136]
["2-aminocyclohexanol","2-aminocyclohexanol","C516358","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2015,"26386397","trans-2-Aminocyclohexanol-based amphiphiles as highly efficient helper lipids for gene delivery by lipoplexes.","26386397",136]
["2-butenal","2-butenal","C012796","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22848562","Induction of heme oxygenase-1 inhibits cell death in crotonaldehyde-stimulated HepG2 cells via the PKC-δ-p38-Nrf2 pathway.","22848562",136]
["2-carboxy-3,4,5-trihydroxypiperidine","2-carboxy-3,4,5-trihydroxypiperidine","C043337","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1984,"6489520","Specific inhibition of human beta-D-glucuronidase and alpha-L-iduronidase by a trihydroxy pipecolic acid of plant origin.","6489520",136]
["2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole","2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole","C492322","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"24222126","Synergistic anti-leukemic effects of CK2 inhibitors and pentabromobenzylisothioureas in vitro.","24222126",136]
["2-hydroxy-4,4'-diamidinostilbene, methanesulfonate salt","2-hydroxy-4,4'-diamidinostilbene, methanesulfonate salt","C049774","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2001,"11872939","Study of the role of the low-affinity neurotrophin receptor p75 in naturally occurring cell death during development of the rat retina.","11872939",136]
["2-Hydroxypropyl-beta-cyclodextrin","2-Hydroxypropyl-beta-cyclodextrin","D000073738","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2004,"14762892","Degradation of NSC-281612 (4-[bis[2-[(methylsulfonyl)oxy]ethyl]amino]-2-methyl-benzaldehyde), an experimental antineoplastic agent: effects of pH, solvent composition, (SBE)7m-beta-CD, and HP-beta-CD on stability.","14762892",136]
["2-mercaptoacetate","2-mercaptoacetate","C017487","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2004,"15137112","Adsorption of mercaptoacetic acid on a colloidal silver surface as investigated by Raman spectroscopy.","15137112",136]
["2-methyl-2-phenyl-3,4-dihydro-2H-benzo(h)chromene-5,6-dione","2-methyl-2-phenyl-3,4-dihydro-2H-benzo(h)chromene-5,6-dione","C588159","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23933437","Novel o-naphthoquinones induce apoptosis of EL-4 T lymphoma cells through the increase of reactive oxygen species.","23933437",136]
["2-naphthol orange","2-naphthol orange","C014722","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2016,"27638463","Facile synthesis of magnetic biochar/Fe3O4 nanocomposites using electro-magnetization technique and its application on the removal of acid orange 7 from aqueous media.","27638463",136]
["2-phenylbenzimidazole","2-phenylbenzimidazole","C117755","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2008,"18314265","A solid phase extraction procedure for Fe3+, Cu2+ and Zn2+ ions on 2-phenyl-1H-benzo[d] imidazole loaded on Triton X-100-coated polyvinyl chloride.","18314265",136]
["2-tert-butylhydroquinone","2-tert-butylhydroquinone","C018855","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"26878773","Antioxidant tert-butylhydroquinone ameliorates arsenic-induced intracellular damages and apoptosis through induction of Nrf2-dependent antioxidant responses as well as stabilization of anti-apoptotic factor Bcl-2 in human keratinocytes.","26878773",136]
["3-((7-ethyl-1H-indol-3-yl)-methyl)-2-methylquinoline","3-((7-ethyl-1H-indol-3-yl)-methyl)-2-methylquinoline","C000617120","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27748837","An indolylquinoline derivative activates DNA damage response and apoptosis in human hepatocellular carcinoma cells.","27748837",136]
["3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one","3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one","C527590","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2008,"18202014","Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth.","18202014",136]
["3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole","3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole","C090937","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2005,"15950964","YC-1-inhibited proliferation of rat mesangial cells through suppression of cyclin D1-independent of cGMP pathway and partially reversed by p38 MAPK inhibitor.","15950964",136]
["3-(8-amino-1-(2-phenylquinolin-7-yl)imidazo(1,5-a)pyrazin-3-yl)-1-methylcyclobutanol","3-(8-amino-1-(2-phenylquinolin-7-yl)imidazo(1,5-a)pyrazin-3-yl)-1-methylcyclobutanol","C551528","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"26951753","Optimisation of a 5-[3-phenyl-(2-cyclic-ether)-methyl-ether]-4-aminopyrrolopyrimidine series of IGF-1R inhibitors.","26951753",136]
["3,3'-diaminodiphenyl ditelluride","3,3'-diaminodiphenyl ditelluride","C477381","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2003,"12491038","Cytometric determination of novel organotellurium compound toxicity in a promyelocytic (HL-60) cell line.","12491038",136]
["3,4,3',4'-tetrachlorobiphenyl","3,4,3',4'-tetrachlorobiphenyl","C028451","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2006,"16263226","Differential effects of PCBs on the induction of apoptosis machinery and PKCalpha translocation in rat renal tubular cell cultures.","16263226",136]
["3,4',5-trimethoxystilbene","3,4',5-trimethoxystilbene","C497286","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2008,"18288419","Stilbene analogues affect cell cycle progression and apoptosis independently of each other in an MCF-7 array of clones with distinct genetic and chemoresistant backgrounds.","18288419",136]
["3,4-dihydroxyphenylethanol","3,4-dihydroxyphenylethanol","C005975","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"26774912","Hydroxytyrosol inhibits phosphatidylserine exposure and suicidal death induced by mercury in human erythrocytes: Possible involvement of the glutathione pathway.","26774912",136]
["3,5-dimethyl-1-thiocarbamoylpyrazole","3,5-dimethyl-1-thiocarbamoylpyrazole","C550100","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20116142","3,5-Dimethyl-1-thiocarbamoylpyrazole and its Pd(II) complexes: synthesis, spectral studies and antitumor activity.","20116142",136]
["3-amino-1-methyl-5H-pyrido(4,3-b)indole","3-amino-1-methyl-5H-pyrido(4,3-b)indole","C019133","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2006,"16910744","Effect of pH on binding of mutagenic heterocyclic amines by the natural biopolymer poly(gamma-glutamic acid).","16910744",136]
["3-aminobenzamide","3-aminobenzamide","C025160","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23846805","Continuous inhibition of poly(ADP-ribose) polymerase does not reduce reperfusion injury in isolated rat heart.","23846805",136]
["3-buten-2-one","3-buten-2-one","C057920","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2007,"17454129","Methyl vinyl ketone induces apoptosis in murine GT1-7 hypothalamic neurons through glutathione depletion and the generation of reactive oxygen species.","17454129",136]
["3-hydrogenkwadaphnin","3-hydrogenkwadaphnin","C505417","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"18829278","3-Hydrogenkwadaphnine, a novel diterpene ester from Dendrostellera lessertii, its role in differentiation and apoptosis of KG1 cells.","18829278",136]
["3-Hydroxybutyric Acid","3-Hydroxybutyric Acid","D020155","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2005,"15762614","Gelatin blending improves the performance of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) films for biomedical application.","15762614",136]
["3-ingenyl angelate","3-ingenyl angelate","C486592","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23991094","RasGRPs are targets of the anti-cancer agent ingenol-3-angelate.","23991094",136]
["3-methylene-2-norbornanone","3-methylene-2-norbornanone","C497854","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2004,"15482940","Identification and structure-activity relationship studies of 3-methylene-2-norbornanone as potent anti-proliferative agents presumably working through p53 mediated apoptosis.","15482940",136]
["3-O-(galactopyranosyl-(1-2)-glucuronopyrnosyl)quillaic acid-28-O-(arabinopyranosyl)-(1-2)-arabinopyranosyl-(1-3)-xylopyranosyl-(1-4)-rhamnopyranosyl-(1-2))-(6-O-acetylglucopyranosyl-(1-3)-4-O-acetylfucopyranoside","3-O-(galactopyranosyl-(1-2)-glucuronopyrnosyl)quillaic acid-28-O-(arabinopyranosyl)-(1-2)-arabinopyranosyl-(1-3)-xylopyranosyl-(1-4)-rhamnopyranosyl-(1-2))-(6-O-acetylglucopyranosyl-(1-3)-4-O-acetylfucopyranoside","C471488","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2002,"12444678","New acylated triterpene saponins from Silene fortunei that modulate lymphocyte proliferation.","12444678",136]
["3-xylene","3-xylene","C031285","7_AO",872,7,"Site of Contact Nasal Tumors","Increase","Nose","D009666","Nose",1,3,2002,"12409535","Are women more sensitive than men to 2-propanol and m-xylene vapours?","12409535",136]
["4-((N,N-dimethylcarbamoyl)oxy)-5-(naphth-1-yl)naphtho(2,3-b)pyrrolo(1,2-d)(1,4)oxazepine","4-((N,N-dimethylcarbamoyl)oxy)-5-(naphth-1-yl)naphtho(2,3-b)pyrrolo(1,2-d)(1,4)oxazepine","C550734","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"19479253","Dual targeting of tumour cells and host endothelial cells by novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines.","19479253",136]
["4-(4-(N-benzoylamino)anilino)-6-methoxy-7-(3-(1-morpholino)propoxy)quinazoline","4-(4-(N-benzoylamino)anilino)-6-methoxy-7-(3-(1-morpholino)propoxy)quinazoline","C474722","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"19686703","Aurora kinase inhibitor ZM447439 induces apoptosis via mitochondrial pathways.","19686703",136]
["4-(cyclopropylamino)-2-((4-(4-(ethylsulfonyl)piperazin-1-yl)phenyl)amino)pyrimidine-5-carboxamide","4-(cyclopropylamino)-2-((4-(4-(ethylsulfonyl)piperazin-1-yl)phenyl)amino)pyrimidine-5-carboxamide","C000595259","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28088788","Dual SYK/JAK inhibition overcomes ibrutinib resistance in chronic lymphocytic leukemia: Cerdulatinib, but not ibrutinib, induces apoptosis of tumor cells protected by the microenvironment.","28088788",136]
["4,4',6-trimethylangelicin","4,4',6-trimethylangelicin","C041621","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2018,"29318693","4,6,4'-trimethylangelicin shows high anti-proliferative activity on DU145 cells under both UVA and blue light.","29318693",136]
["4,4-difluoro-4-bora-3a,4a-diaza-s-indacene","4,4-difluoro-4-bora-3a,4a-diaza-s-indacene","C095489","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"25056486","Photo- and pH-tunable multicolor fluorescent nanoparticle-based spiropyran- and BODIPY-conjugated polymer with graphene oxide.","25056486",136]
["4,5-dioxovaleric acid","4,5-dioxovaleric acid","C007509","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1981,"6976135","The determination of 4,5-dioxovaleric acid in plant preparations and a procedure for the assay of L-alanine:4,5-dioxovaleric acid aminotransferase (EC 2.6.1.43) activity.","6976135",136]
["4-amino-5-fluoro-3-(5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl)quinolin-2(1H)-one","4-amino-5-fluoro-3-(5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl)quinolin-2(1H)-one","C500007","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2014,"25186177","Prostate cancer cell-stromal cell crosstalk via FGFR1 mediates antitumor activity of dovitinib in bone metastases.","25186177",136]
["4-amino-tetrahydrobiopterin","4-amino-tetrahydrobiopterin","C106930","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2001,"11448802","The 4-amino analogue of tetrahydrobiopterin efficiently prolongs murine cardiac-allograft survival.","11448802",136]
["4-bromomethyl-6,7-dimethoxycoumarin","4-bromomethyl-6,7-dimethoxycoumarin","C053769","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1992,"1385723","Labeling the (Ca(2+)-Mg2+)-ATPase of sarcoplasmic reticulum with 4-(bromomethyl)-6,7-dimethoxycoumarin: detection of conformational changes.","1385723",136]
["4-Butyrolactone","4-Butyrolactone","D015107","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2006,"16885129","Factors affecting stability of z-ligustilide in the volatile oil of radix angelicae sinensis and ligusticum chuanxiong and its stability prediction.","16885129",136]
["4-chlorophenol","4-chlorophenol","C029107","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2008,"18207637","Enzymatic removal of phenol and p-chlorophenol in enzyme reactor: horseradish peroxidase immobilized on magnetic beads.","18207637",136]
["4-cresol","4-cresol","C032538","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2001,"11255958","[Features of extracting phenol and 4-methylphenol from aqueous solutions].","11255958",136]
["4-hydroxy-2-nonenal","4-hydroxy-2-nonenal","C027576","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2003,"12893005","4-hydroxynonenal and transforming growth factor-beta1 expression in colon cancer.","12893005",136]
["4-hydroxy-5-nitrophenyl acetic acid","4-hydroxy-5-nitrophenyl acetic acid","C026242","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1987,"3614215","Maturation of the immune response to (4-hydroxy-3-nitrophenyl)-acetyl (NP) haptens in C57BL/6 mice.","3614215",136]
["4-hydroxy-N-desmethyltamoxifen","4-hydroxy-N-desmethyltamoxifen","C055492","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2015,"26119504","Development and validation of an UPLC-MS/MS method for the quantification of tamoxifen and its main metabolites in human scalp hair.","26119504",136]
["4-ketocyclohexanecarboxylic acid","4-ketocyclohexanecarboxylic acid","C008225","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1993,"8281951","Aromatization of 4-oxocyclohexanecarboxylic acid to 4-hydroxybenzoic acid by two distinctive desaturases from Corynebacterium cyclohexanicum. Properties of two desaturases.","8281951",136]
["4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine","4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine","C549066","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"26546572","NF-κB transcriptional inhibition ameliorates cisplatin-induced acute kidney injury (AKI).","26546572",136]
["4-nitrophenyl","4-nitrophenyl","C024719","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28747001","Novel thiosemicarbazide derivatives with 4-nitrophenyl group as multi-target drugs: α-glucosidase inhibitors with antibacterial and antiproliferative activity.","28747001",136]
["4-phenylbutyric acid","4-phenylbutyric acid","C075773","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2012,"23208051","[Molecular pharmacological studies on the protection mechanism against endoplasmic reticulum stress-induced neurodegenerative disease].","23208051",136]
["4-phenylenediamine","4-phenylenediamine","C029728","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"21786225","p-Aminophenol and p-paraphenylenediamine induce injury and apoptosis of human HK-2 proximal tubular epithelial cells.","21786225",136]
["5-(2,4-dihydroxy-5-isopropylphenyl)-4-(4-morpholin-4-ylmethylphenyl)isoxazole-3-carboxylic acid ethylamide","5-(2,4-dihydroxy-5-isopropylphenyl)-4-(4-morpholin-4-ylmethylphenyl)isoxazole-3-carboxylic acid ethylamide","C528044","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2012,"22441439","Radiosensitizing effect of the novel Hsp90 inhibitor NVP-AUY922 in human tumour cell lines silenced for Hsp90α.","22441439",136]
["5-(4-(4-(diethylamino)butyl)-1-piperidinyl)acetyl-5H-dibenz(b,f)azepine","5-(4-(4-(diethylamino)butyl)-1-piperidinyl)acetyl-5H-dibenz(b,f)azepine","C416546","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2007,"17876039","Improved low molecular weight Myc-Max inhibitors.","17876039",136]
["5,5'-dimethyl bis(o-aminophenoxy)ethane-N,N,N',N' tetraacetic acetoxymethyl ester","5,5'-dimethyl bis(o-aminophenoxy)ethane-N,N,N',N' tetraacetic acetoxymethyl ester","C460021","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,3,2002,"12371969","Atrial natriuretic peptide impairs the stimulatory effect of angiotensin II on H+-ATPase.","12371969",136]
["5,6,11,12,17,18,23,24-octahydrocyclododeca(1,2-b-4,5-b'-7,8-''-10,11-b''')tetraindole","5,6,11,12,17,18,23,24-octahydrocyclododeca(1,2-b-4,5-b'-7,8-''-10,11-b''')tetraindole","C572341","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2012,"22905241","Induction of endoplasmic reticulum stress response by the indole-3-carbinol cyclic tetrameric derivative CTet in human breast cancer cell lines.","22905241",136]
["5-acetylneuraminyl-(2-3)-galactosyl-(1-4)-(fucopyranosyl-(1-3))-N-acetylglucosamine","5-acetylneuraminyl-(2-3)-galactosyl-(1-4)-(fucopyranosyl-(1-3))-N-acetylglucosamine","C086527","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2013,"23799130","Expression of ST3GAL4 leads to SLe(x) expression and induces c-Met activation and an invasive phenotype in gastric carcinoma cells.","23799130",136]
["5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone","5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone","C521815","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"23221529","Identification of 5-hydroxy-3,6,7,8,3´,4´-hexamethoxyflavone from Hizikia fusiforme involved in the induction of the apoptosis mediators in human AGS carcinoma cells.","23221529",136]
["5-methyl-1-(3-fluorophenyl)-2-(1H)-pyridone","5-methyl-1-(3-fluorophenyl)-2-(1H)-pyridone","C511655","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24337009","Fluorofenidone attenuates hepatic fibrosis by suppressing the proliferation and activation of hepatic stellate cells.","24337009",136]
["5-methyltetrahydrofolate","5-methyltetrahydrofolate","C005984","6_KE",876,6,"Mutations in Critical Genes","Increase","Genomic Instability","D042822","Genomic Instability",1,1,2017,"28461497","Folate rescues vitamin B12 depletion-induced inhibition of nuclear thymidylate biosynthesis and genome instability.","28461497",136]
["6-(2-(4-methoxyphenyl)ethyl)-9-((pyridine-3-ylmethyl)amino)pyrido(2',1'-2,3)imidazo(4,5-c)isoquinolin-5(6H)-one","6-(2-(4-methoxyphenyl)ethyl)-9-((pyridine-3-ylmethyl)amino)pyrido(2',1'-2,3)imidazo(4,5-c)isoquinolin-5(6H)-one","C559146","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"20830720","MT119, a new planar-structured compound, targets the colchicine site of tubulin arresting mitosis and inhibiting tumor cell proliferation.","20830720",136]
["6-aminoquinolyl-N-hydroxysuccinimidyl carbamate","6-aminoquinolyl-N-hydroxysuccinimidyl carbamate","C078178","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"22349763","New approach for amino acid profiling in human plasma by selective fluorescence derivatization.","22349763",136]
["6-bromoisatin","6-bromoisatin","C573108","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"24368567","6-bromoisatin found in muricid mollusc extracts inhibits colon cancer cell proliferation and induces apoptosis, preventing early stage tumor formation in a colorectal cancer rodent model.","24368567",136]
["6-ketocholestanol","6-ketocholestanol","C063833","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2003,"12672607","Influence of lipophilic counter-ions in combination with phloretin and 6-ketocholestanol on the skin permeation of 5-aminolevulinic acid.","12672607",136]
["7,3'-dihydroxy-4'-methoxyisoflavone","7,3'-dihydroxy-4'-methoxyisoflavone","C121707","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"23797737","Calycosin entered HUVECs and ameliorated AGEs-promoted cell apoptosis via the Bcl-2 pathway.","23797737",136]
["7,8-dihydrobiopterin","7,8-dihydrobiopterin","C017226","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1995,"7727440","Catalytic characterization of 4a-hydroxytetrahydropterin dehydratase.","7727440",136]
["7,8-dimethylalloxazine","7,8-dimethylalloxazine","C001559","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2006,"16536619","Photosensitizing effect of riboflavin, lumiflavin, and lumichrome on the generation of volatiles in soy milk.","16536619",136]
["7-hydroxystaurosporine","7-hydroxystaurosporine","C054852","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,1997,"9815601","UCN-01 in ovary cancer cells: effective as a single agent and in combination with cis-diamminedichloroplatinum(II)independent of p53 status.","9815601",136]
["7-methoxyheptaphylline","7-methoxyheptaphylline","C557425","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"25556496","Heptaphylline induces apoptosis in human colon adenocarcinoma cells through bid and Akt/NF-κB (p65) pathways.","25556496",136]
["8-azapurine","8-azapurine","C015008","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2005,"15993080","8-Azapurines as new inhibitors of cyclin-dependent kinases.","15993080",136]
["8-epi-prostaglandin F2alpha","8-epi-prostaglandin F2alpha","C075750","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2005,"15650411","Isoprostanes and the kidney.","15650411",136]
["9-(tetrahydro-2-furyl)-adenine","9-(tetrahydro-2-furyl)-adenine","C017759","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2000,"11118638","kappa-Opioid receptor potentiates apoptosis via a phospholipase C pathway in the CNE2 human epithelial tumor cell line.","11118638",136]
["9,10-Dimethyl-1,2-benzanthracene","9,10-Dimethyl-1,2-benzanthracene","D015127","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,1,1994,"8142019","Infrequent p53 mutations in 7,12-dimethylbenz[a]anthracene-induced mammary tumors in BALB/c and p53 hemizygous mice.","8142019",136]
["9H-purine-9-propanamine, 6-amino-8-((6-iodo-1,3-benzodioxol-5-yl)thio)-N-(1-methylethyl)-","9H-purine-9-propanamine, 6-amino-8-((6-iodo-1,3-benzodioxol-5-yl)thio)-N-(1-methylethyl)-","C526550","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28032595","Prospective identification of resistance mechanisms to HSP90 inhibition in KRAS mutant cancer cells.","28032595",136]
["AAL 881","AAL 881","C514876","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2006,"16551863","Inhibitors of Raf kinase activity block growth of thyroid cancer cells with RET/PTC or BRAF mutations in vitro and in vivo.","16551863",136]
["ABO Blood-Group System","ABO Blood-Group System","D000017","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1973,"4791851","[Fractionation of blood group substance B from the gastric mucosa of the horse].","4791851",136]
["ABT-737","ABT-737","C501332","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"20160166","Apoptosis induced by JAK2 inhibition is mediated by Bim and enhanced by the BH3 mimetic ABT-737 in JAK2 mutant human erythroid cells.","20160166",136]
["acankoreoside J","acankoreoside J","C549464","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22941493","Promotion effect of acankoreoside J, a lupane-triterpene in Acanthopanax koreanum, on hair growth.","22941493",136]
["acemannan","acemannan","C058414","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"26049685","Acemannan accelerates cell proliferation and skin wound healing through AKT/mTOR signaling pathway.","26049685",136]
["Acetaldehyde","Acetaldehyde","D000079","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,3,2013,"24147580","Chloroacetonitrile and n,2-dichloroacetamide formation from the reaction of chloroacetaldehyde and monochloramine in water.","24147580",136]
["Acetaminophen","Acetaminophen","D000082","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"21857903","Integrated proteomic and transcriptomic investigation of the acetaminophen toxicity in liver microfluidic biochip.","21857903",136]
["Acetaminophen","Acetaminophen","D000082","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2013,"23180758","Capillary electrophoretic determination of antimigraine formulations containing caffeine, ergotamine, paracetamol and domperidone or metoclopramide.","23180758",136]
["Acetaminophen","Acetaminophen","D000082","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1982,"7113726","Modulation of N-hydroxyparacetamol cytotoxicity in suspensions of isolated rat hepatocytes.","7113726",136]
["Acetaminophen","Acetaminophen","D000082","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,2,1986,"3940815","Lethal enhancement of therapeutic doses of acetaminophen by alcohol.","3940815",136]
["Acetazolamide","Acetazolamide","D000086","1_MIE",867,1,"Intracellular pH","Decrease","Acid-Base Equilibrium","D000136","Acid-Base Equilibrium",2,3,1988,"3136134","Effects of acetazolamide on cerebral acid-base balance.","3136134",136]
["Acetazolamide","Acetazolamide","D000086","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,3,1992,"1623955","Effects of intravenous acetazolamide on retinal pH in the cat.","1623955",136]
["Acetic Acid","Acetic Acid","D019342","1_MIE",867,1,"Intracellular pH","Decrease","Acid-Base Equilibrium","D000136","Acid-Base Equilibrium",2,3,1989,"2761214","[Dynamics of acid-base equilibrium of the blood in humans a long-term exposure to an atmosphere containing acetic acid vapors].","2761214",136]
["Acetic Acid","Acetic Acid","D019342","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2009,"19269576","A peculiar stimulatory effect of acetic and lactic acid on growth and fermentative metabolism of Zygosaccharomyces bailii.","19269576",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C23491,B23491)","v":"Acetic Acid"},"Acetic Acid","D019342","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J23491,K23491)","v":"Necrosis"},"D009336","Necrosis",1,1,2012,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q23491,Q23491)","v":"22486870"},"Topical application of acetic acid in cytoreduction of gastric cancer. A technical report using mouse model.","22486870",136]
["Acetone","Acetone","D000096","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Atrophy","D001284","Atrophy",1,2,2000,"10728921","Toxicity study of di(2-ethylhexyl)phthalate (DEHP) in combination with acetone in rats.","10728921",136]
["acetonitrile","acetonitrile","C032159","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2013,"23161102","Non-native states of bovine beta-lactoglobulin induced by acetonitrile: pH-dependent unfolding of the two genetic variants A and B.","23161102",136]
["Acetylcholine","Acetylcholine","D000109","1_MIE",867,1,"Intracellular pH","Decrease","Acid-Base Equilibrium","D000136","Acid-Base Equilibrium",2,3,1989,"2501287","CSF acidosis augments ventilation through cholinergic mechanisms.","2501287",136]
["Acetylcholine","Acetylcholine","D000109","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1963,"14126899","[EFFECT OF EXCITATION OF THE MESENCEPHALIC RETICULAR FORMATION ON THE CIRCULATORY RATE AND THE FUNCTIONAL BIOCHEMISTRY OF THE BRAIN].","14126899",136]
["Acetylcholine","Acetylcholine","D000109","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1966,"5963442","Hydrolysis of neutral substrates by acetylcholinesterase.","5963442",136]
["Acetylglucosamine","Acetylglucosamine","D000117","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2011,"20887712","Altered O-GlcNAc modification and phosphorylation of mitochondrial proteins in myoblast cells exposed to high glucose.","20887712",136]
["Acid Rain","Acid Rain","D015258","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2000,"10682372","Critical loads of acidity for surface waters in China.","10682372",136]
["Acid Red-151","Acid Red-151","C479461","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2003,"12929811","A kinetic study on the decolorization of aqueous solutions of Acid Red-151 by ozonation.","12929811",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C24899,B24899)","v":"Acitretin"},"Acitretin","D017255","5_KE",768,5,"Cytotoxicity","Increase",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J24899,K24899)","v":"Apoptosis"},"D017209","Apoptosis",1,2,2013,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q24899,Q24899)","v":"23384448"},"Acitretin affects bioenergetics of liver mitochondria and promotes mitochondrial permeability transition: potential mechanisms of hepatotoxicity.","23384448",136]
["Acriflavine","Acriflavine","D000167","7_AO",872,7,"Site of Contact Nasal Tumors","Increase","Nose","D009666","Nose",1,1,1981,"7252349","Local acriflavine: a new therapy for rhinoscleroma.","7252349",136]
["Acrylamide","Acrylamide","D020106","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2009,"19407212","Discrete responses of myenteric neurons to structural and functional damage by neurotoxins in vitro.","19407212",136]
["acrylic acid","acrylic acid","C036658","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2010,"19828121","One-pot synthesis of pH- and thermo-sensitive chitosan-based nanoparticles by the polymerization of acrylic acid/chitosan with macro-RAFT agent.","19828121",136]
["Acrylonitrile","Acrylonitrile","D000181","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24248151","Cytotoxic effects of acrylonitrile on human umbilical cord mesenchymal stem cells in vitro.","24248151",136]
["Acyclovir","Acyclovir","D000212","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,1,2002,"11793392","Importance of C-terminus of herpes simplex virus type 1 thymidine kinase for maintaining thymidine kinase and acyclovir-phosphorylation activities.","11793392",136]
["adefovir","adefovir","C053001","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2001,"11563068","Enhanced inhibition of HIV-1 replication in macrophages by antisense oligonucleotides, ribozymes and acyclic nucleoside phosphonate analogs delivered in pH-sensitive liposomes.","11563068",136]
["Adenine","Adenine","D000225","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2000,"10810395","Anticancer effect of PMEDAP--monitoring of apoptosis.","10810395",136]
["Adenine","Adenine","D000225","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2002,"12444612","Acidity of adenine and adenine derivatives and biological implications. A computational and experimental gas-phase study.","12444612",136]
["Adenine","Adenine","D000225","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1997,"9423141","Oral formulations of adefovir dipivoxil: in vitro dissolution and in vivo bioavailability in dogs.","9423141",136]
["afatinib","afatinib","C522924","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"25268372","Afatinib demonstrates remarkable activity against HER2-amplified uterine serous endometrial cancer in vitro and in vivo.","25268372",136]
["afatinib","afatinib","C522924","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23367880","Treatment with a combination of the ErbB (HER) family blocker afatinib and the IGF-IR inhibitor, NVP-AEW541 induces synergistic growth inhibition of human pancreatic cancer cells.","23367880",136]
["Aflatoxin B1","Aflatoxin B1","D016604","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"18274443","The adsorption of aflatoxin B1 by detonation-synthesis nanodiamonds.","18274443",136]
["AG-012986","AG-012986","C512484","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22095879","Off-target immune cell toxicity caused by AG-012986, a pan-CDK inhibitor, is associated with inhibition of p38 MAPK phosphorylation.","22095879",136]
["Agkistrodon venoms","Agkistrodon venoms","C031442","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,2,1994,"8061942","The role of extracellular ions in the pathogenesis of myonecrosis induced by a myotoxin isolated from Broad-Banded copperhead (Agkistrodon contortrix laticinctus) venom.","8061942",136]
["AK 2123","AK 2123","C072690","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"24065488","Radiation enhancing effects with the combination of sanazole and irinotecan in hypoxic HeLa human cervical cancer cell line.","24065488",136]
["Albuterol","Albuterol","D000420","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2006,"16434240","Chiral separation of salbutamol and bupivacaine by capillary electrophoresis using dual neutral cyclodextrins as selectors and its application to pharmaceutical preparations and rat blood samples assay.","16434240",136]
["Alendronate","Alendronate","D019386","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"21604021","Cytotoxicity of the new antimetabolite-bisphosphonate (5-FdU-alendronate) in comparison to standard therapeutics on breast and ovarian cancer cell lines in the ATP tumor chemosensitivity assay.","21604021",136]
["alginic acid","alginic acid","C008970","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2010,"19833385","Alginate microcapsule for propagation and directed differentiation of hESCs to definitive endoderm.","19833385",136]
["alginic acid","alginic acid","C008970","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2013,"23577091","Alginic acid-coated chitosan nanoparticles loaded with legumain DNA vaccine: effect against breast cancer in mice.","23577091",136]
["alginic acid","alginic acid","C008970","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"17630926","Controlled release of the pineal hormone melatonin from hydroxypropylmethylcellulose/sodium alginate matrices in aqueous media containing dioctyl sulfosuccinate.","17630926",136]
["alginic acid","alginic acid","C008970","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"23741795","Kinetics of fungal extracellular alpha-amylase from Fusarium solani immobilized in calcium alginate beads.","23741795",136]
["aliskiren","aliskiren","C446481","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"26464664","KRT6 interacting with notch1 contributes to progression of renal cell carcinoma, and aliskiren inhibits renal carcinoma cell lines proliferation in vitro.","26464664",136]
["alitretinoin","alitretinoin","C103303","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"20102612","Retinoic acid protects human breast cancer cells against etoposide-induced apoptosis by NF-kappaB-dependent but cIAP2-independent mechanisms.","20102612",136]
["allicin","allicin","C006452","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"27412589","Allicin improves cardiac function by protecting against apoptosis in rat model of myocardial infarction.","27412589",136]
["Allura Red AC Dye","Allura Red AC Dye","C005915","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2011,"21349311","Spectrophotometric determination of trace levels of allura red in water samples after separation and preconcentration.","21349311",136]
["Almitrine","Almitrine","D015765","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1987,"2887541","Almitrine bismesylate and the central and peripheral ventilatory response to CO2.","2887541",136]
["aloe emodin","aloe emodin","C518327","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2004,"15531293","Aloe-emodin modulates PKC isozymes, inhibits proliferation, and induces apoptosis in U-373MG glioma cells.","15531293",136]
["alpha-galactosylceramide","alpha-galactosylceramide","C493154","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2007,"17264815","Effects of cyclosporin A on the activation of natural killer T cells induced by alpha-galactosylceramide.","17264815",136]
["alpha-ketoglutaric acid","alpha-ketoglutaric acid","C029743","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"17429948","Purification and characterization of the FeII- and alpha-ketoglutarate-dependent xanthine hydroxylase from Aspergillus nidulans.","17429948",136]
["alpha-Linolenic Acid","alpha-Linolenic Acid","D017962","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"21787405","Effect of α-linolenic acid on endoplasmic reticulum stress-mediated apoptosis of palmitic acid lipotoxicity in primary rat hepatocytes.","21787405",136]
["alpha-Tocopherol","alpha-Tocopherol","D024502","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2009,"19781538","Effect of alpha tocopherol acetate in Walker 256/B cells-induced oxidative damage in a rat model of breast cancer skeletal metastases.","19781538",136]
["alpha-tricalcium phosphate","alpha-tricalcium phosphate","C485828","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1994,"7876278","Studies on calcium phosphate precipitation: effects of metal ions used in dental materials.","7876278",136]
["Alprostadil","Alprostadil","D000527","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1986,"3087810","Human duodenal mucosal bicarbonate secretion. Evidence for basal secretion and stimulation by hydrochloric acid and a synthetic prostaglandin E1 analogue.","3087810",136]
["Alprostadil","Alprostadil","D000527","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,1991,"1871850","Effects of combined therapy with prostaglandin E1 and cyclosporine A on rat heart allograft survival.","1871850",136]
["aluminum chloride","aluminum chloride","C010845","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2010,"20450109","Treatment of paper and pulp mill effluent by coagulation.","20450109",136]
["Aluminum Hydroxide","Aluminum Hydroxide","D000536","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1974,"4823546","Adsorption of bile by aluminum hydroxide.","4823546",136]
["Aluminum Oxide","Aluminum Oxide","D000537","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2003,"12600382","New method of treating dilute mineral acids using magnesium-aluminum oxide.","12600382",136]
["Aluminum Oxide","Aluminum Oxide","D000537","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"17579741","Time-resolved in situ XAS study of the preparation of supported gold clusters.","17579741",136]
["Aluminum Oxide","Aluminum Oxide","D000537","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"24965747","Aqueous stability of alumina and silica perhydrate hydrogels: experiments and computations.","24965747",136]
["alvocidib","alvocidib","C077990","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2003,"12517783","Flavopiridol down-regulates antiapoptotic proteins and sensitizes human breast cancer cells to epothilone B-induced apoptosis.","12517783",136]
["Amaranth Dye","Amaranth Dye","D000548","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"24799202","Simultaneous determination of the isomers of Ponceau 4R and Amaranth using an expanded graphite paste electrode.","24799202",136]
["amariin","amariin","C581165","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22982332","Geraniin and amariin, ellagitannins from Phyllanthus amarus, protect liver cells against ethanol induced cytotoxicity.","22982332",136]
["Amifostine","Amifostine","D004999","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2006,"16737611","[Protective effect of amifostine on cisplatin-induced nephrotoxicity and its mechanism].","16737611",136]
["Amiloride","Amiloride","D000584","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"17431790","Acute acidification or amiloride treatment suppresses the ability of Hsp70 to inhibit heat-induced apoptosis.","17431790",136]
["Amiloride","Amiloride","D000584","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,1,1996,"8900133","Kinetic interconversion of rat and bovine homologs of the alpha subunit of an amiloride-sensitive Na+ channel by C-terminal truncation of the bovine subunit.","8900133",136]
["aminobenzothiazole compound","aminobenzothiazole compound","C523775","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"21612977","Synthesis, spectral, antimicrobial and antitumor assessment of Schiff base derived from 2-aminobenzothiazole and its transition metal complexes.","21612977",136]
["Aminoimidazole Carboxamide","Aminoimidazole Carboxamide","D000620","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"27783307","Therapeutic Effects of AICAR and DOX Conjugated Multifunctional Nanoparticles in Sensitization and Elimination of Cancer Cells via Survivin Targeting.","27783307",136]
["Aminopyrine","Aminopyrine","D000632","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1981,"7323083","Explanation of the effects of imidazole, aminopyrine, and thiocyanate on gastric secretion.","7323083",136]
["Amiodarone","Amiodarone","D000638","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2006,"16971508","Hepatocellular toxicity and pharmacological effect of amiodarone and amiodarone derivatives.","16971508",136]
["ammelide","ammelide","C067139","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2011,"21181594","Migration of melamine from can coatings cross-linked with melamine-based resins, into food simulants and foods.","21181594",136]
["Ammonia","Ammonia","D000641","1_MIE",867,1,"Intracellular pH","Decrease","Acid-Base Imbalance","D000137","Acid-Base Imbalance",2,2,1985,"4055311","Ammonia metabolism during acid-base disturbance.","4055311",136]
["Ammonia","Ammonia","D000641","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1992,"1295383","[Acute toxicity of ammonia to Artemia sp].","1295383",136]
["Ammonia","Ammonia","D000641","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2005,"16202811","Catalytic wet oxidation of ammonia: why is N2 formed preferentially against NO3 -?","16202811",136]
["Ammonia","Ammonia","D000641","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2009,"19635366","Precipitation as a simple and versatile method for preparation of optical nanochemosensors.","19635366",136]
["Ammonia","Ammonia","D000641","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"24291310","Strong influence of medium pH condition on gas-phase biofilter ammonia removal, nitrous oxide generation and microbial communities.","24291310",136]
["Ammonia","Ammonia","D000641","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1985,"3905824","Antimalarials increase vesicle pH in Plasmodium falciparum.","3905824",136]
["Ammonia","Ammonia","D000641","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1973,"4355040","Rapid determination of ammonia in a perchloric acid supernate from blood, by use of an ammonia-specific electrode.","4355040",136]
["Ammonia","Ammonia","D000641","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1980,"7415226","[Prevention of artificial ammonia synthesis in vitro].","7415226",136]
["Ammonium Chloride","Ammonium Chloride","D000643","1_MIE",867,1,"Intracellular pH","Decrease","Acid-Base Equilibrium","D000136","Acid-Base Equilibrium",2,2,1970,"5517965","Ammonium chloride as an adjuvant to diphenylhydantoin therapy, and pH, base bicarbonate and sodium in the serum of forty mentally subnormal epileptics.","5517965",136]
["Ammonium Chloride","Ammonium Chloride","D000643","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1989,"2725680","Cell membranes impermeable to NH3.","2725680",136]
["Ammonium Chloride","Ammonium Chloride","D000643","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1984,"6698874","Evaluation of ammonium chloride as a urinary acidifier in the cat.","6698874",136]
["Amobarbital","Amobarbital","D000654","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1965,"5843083","Effect of protein binding of barbiturates on their rate of removal during peritoneal dialysis.","5843083",136]
["Amoxicillin","Amoxicillin","D000658","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1993,"8219698","Simple analysis of amoxycillin in plasma by high performance liquid chromatography with internal standardization and ultraviolet detection.","8219698",136]
["Amphetamine","Amphetamine","D000661","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1999,"10369328","Amphetamine and fenproporex levels following multidose administration of fenproporex.","10369328",136]
["Amphotericin B","Amphotericin B","D000666","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"17336066","Synthesis and characterisation of a new pH-sensitive amphotericin B--poly(ethylene glycol)-b-poly(L-lysine) conjugate.","17336066",136]
["Ampicillin","Ampicillin","D000667","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1983,"6361948","[In vitro hydrolysis of an ampicillin ester. I. Microbiologic evaluation].","6361948",136]
["amylovoran","amylovoran","C100769","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"23944160","The tail-associated depolymerase of Erwinia amylovora phage L1 mediates host cell adsorption and enzymatic capsule removal, which can enhance infection by other phage.","23944160",136]
["anacardic acid","anacardic acid","C088115","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20197399","Anacardic acid inhibits estrogen receptor alpha-DNA binding and reduces target gene transcription and breast cancer cell proliferation.","20197399",136]
["andrographolide","andrographolide","C030419","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2009,"19695125","Intracellular glutathione regulates Andrographolide-induced cytotoxicity on hepatoma Hep3B cells.","19695125",136]
["anibamine","anibamine","C488244","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22901310","Structure activity relationship studies of natural product chemokine receptor CCR5 antagonist anibamine toward the development of novel anti prostate cancer agents.","22901310",136]
["aniline","aniline","C023650","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2015,"26172392","High-capacity adsorption of aniline using surface modification of lignocellulose-biomass jute fibers.","26172392",136]
["anthracene","anthracene","C034020","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2001,"11302571","Biodegradation of phenanthrene in river sediment.","11302571",136]
["anthrax toxin","anthrax toxin","C030325","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2009,"19165720","An approach to characterizing single-subunit mutations in multimeric prepores and pores of anthrax protective antigen.","19165720",136]
["Antiphein","Antiphein","C014337","1_MIE",867,1,"Intracellular pH","Decrease","Acid-Base Equilibrium","D000136","Acid-Base Equilibrium",2,3,1980,"7450002","[Effect of the structural characteristics of the alkyl derivatives of imidazole and pyrazole dicarboxylic acid diamides on body respiratory functions].","7450002",136]
["antofine","antofine","C473343","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23294831","Design, synthesis, and evaluation of a water-soluble antofine analogue with high antiproliferative and antitumor activity.","23294831",136]
["apaziquone","apaziquone","C060817","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1996,"8885332","The autoxidation of the reduced forms of EO9.","8885332",136]
["Apigenin","Apigenin","D047310","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27514990","Neuroprotective effects of apigenin against inflammation, neuronal excitability and apoptosis in an induced pluripotent stem cell model of Alzheimer's disease.","27514990",136]
["apigetrin","apigetrin","C057792","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"26656314","Effect of apigenin-7-glucoside, genkwanin and naringenin on tyrosinase activity and melanin synthesis in B16F10 melanoma cells.","26656314",136]
["araban","araban","C030080","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2010,"20566287","Chrysosporium lucknowense arabinohydrolases effectively degrade sugar beet arabinan.","20566287",136]
["Arabinose","Arabinose","D001089","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1991,"1867381","Synthesis of methyl 5-O-trans-feruloyl-alpha-L-arabinofuranoside and its use as a substrate to assess feruloyl esterase activity.","1867381",136]
["Arachidonic Acid","Arachidonic Acid","D016718","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2013,"23336521","Aging is associated with altered inflammatory, arachidonic acid cascade, and synaptic markers, influenced by epigenetic modifications, in the human frontal cortex.","23336521",136]
["Arachidonic Acid","Arachidonic Acid","D016718","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,1995,"7537544","Role of cytochrome P-450 enzymes and metabolites of arachidonic acid in the control of vascular tone.","7537544",136]
["aristolactam I","aristolactam I","C121135","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2004,"14970885","[Cellular mechanism of renal proximal tubular epithelial cell injury induced by aristolochic acid I and aristololactam I].","14970885",136]
["aristolochic acid I","aristolochic acid I","C000228","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23939141","Autophagy induction promotes aristolochic acid-I-induced renal injury in vivo and in vitro.","23939141",136]
["arsenic acid","arsenic acid","C025657","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"22161146","Removal of arsenate from groundwater by electrocoagulation method.","22161146",136]
["arsenic trioxide","arsenic trioxide","C006632","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,1999,"11776809","[Glutathione synthesis inhibitor enhances arsenic trioxide-induced apoptosis].","11776809",136]
["arsenic trioxide","arsenic trioxide","C006632","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2006,"16467208","MEK1 inhibition sensitizes primary acute myelogenous leukemia to arsenic trioxide-induced apoptosis.","16467208",136]
["arsenic trioxide","arsenic trioxide","C006632","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2007,"17768137","Arsenic trioxide entered cerebrospinal fluid with the help of mannitol overwhelm the meningeal relapse of acute promyelocytic leukemia.","17768137",136]
["arsenic trioxide","arsenic trioxide","C006632","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22535156","Darinaparsin: solid tumor hypoxic cytotoxin and radiosensitizer.","22535156",136]
["arsenic trioxide","arsenic trioxide","C006632","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27212442","Arsenic trioxide plus PX-478 achieves effective treatment in pancreatic ductal adenocarcinoma.","27212442",136]
["arsenic trioxide","arsenic trioxide","C006632","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,1998,"9862629","Application of heavy metal and cytokine for differentiation-inducing therapy in acute promyelocytic leukemia.","9862629",136]
["arsenic trioxide","arsenic trioxide","C006632","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"25303017","Tetraarsenic oxide-induced inhibition of malignant glioma cell invasion in vitro via a decrease in matrix metalloproteinase secretion and protein kinase B phosphorylation.","25303017",136]
["arsenite","arsenite","C015001","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2003,"14643419","Nitric oxide production by arsenite.","14643419",136]
["artemether","artemether","C032942","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2008,"18380913","Effect of chitosan crosslinking on bitterness of artemether using response surface methodology.","18380913",136]
["artemisinine","artemisinine","C031327","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2017,"28447781","Artemisinin Protects Retinal Neuronal Cells against Oxidative Stress and Restores Rat Retinal Physiological Function from Light Exposed Damage.","28447781",136]
["artesunate","artesunate","C039726","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1999,"10701927","Detection and separation of artesunate and artelinic acid with capillary zone electrophoresis.","10701927",136]
["Asbestos","Asbestos","D001194","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Metaplasia","D008679","Metaplasia",2,2,1986,"3010528","[Characteristics of morphological changes in nasal mucosa of workers exposed to chrysotile-asbestos dust].","3010528",136]
["Ascorbic Acid","Ascorbic Acid","D001205","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2005,"16187034","Vitamins inhibit oxidant-induced apoptosis of corneal endothelial cells.","16187034",136]
["Ascorbic Acid","Ascorbic Acid","D001205","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2009,"19326901","Ascorbic acid promotes detoxification and elimination of 4-hydroxy-2(E)-nonenal in human monocytic THP-1 cells.","19326901",136]
["Ascorbic Acid","Ascorbic Acid","D001205","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28867735","Effects of Ascorbyl-2-phosphate Magnesium on Human Keratinocyte Toxicity and Pathological Changes by Sorafenib.","28867735",136]
["Ascorbic Acid","Ascorbic Acid","D001205","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2000,"10691617","Protein binding in deactivation of ferrylmyoglobin by chlorogenate and ascorbate.","10691617",136]
["Ascorbic Acid","Ascorbic Acid","D001205","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1991,"1823402","The action of the couple ascorbic acid--Cu(II) on NAD(+)-coenzymatic function.","1823402",136]
["Ascorbic Acid","Ascorbic Acid","D001205","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1991,"2004360","Comparative bladder tumor promoting activity of sodium saccharin, sodium ascorbate, related acids, and calcium salts in rats.","2004360",136]
["Ascorbic Acid","Ascorbic Acid","D001205","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1967,"4385354","[Studies on the kinetics of microsomal NADH:semidehydroascorbate oxidoreductase].","4385354",136]
["Ascorbic Acid","Ascorbic Acid","D001205","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1993,"8435869","High gastric juice ascorbic acid concentrations in members of a gastric cancer family.","8435869",136]
["asiatic acid","asiatic acid","C017032","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27213437","Asiatic Acid Prevents the Deleterious Effects of Valproic Acid on Cognition and Hippocampal Cell Proliferation and Survival.","27213437",136]
["asolectin","asolectin","C024990","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1985,"3840208","Selective transport of Li+ across lipid bilayer membranes mediated by an ionophore of novel design (ETH1644).","3840208",136]
["Aspirin","Aspirin","D001241","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2009,"19706045","Aspirin induces apoptosis in mesenchymal stem cells requiring Wnt/beta-catenin pathway.","19706045",136]
["Aspirin","Aspirin","D001241","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25649906","Simultaneous treatment with statins and aspirin reduces the risk of prostate cancer detection and tumorigenic properties in prostate cancer cell lines.","25649906",136]
["Aspirin","Aspirin","D001241","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1985,"3922330","[Interactions between acetylsalicylic acid and lysine in solution].","3922330",136]
["Aspirin","Aspirin","D001241","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1997,"9418940","Sex differences in the enzymatic hydrolysis of acetylsalicylic acid by microsomes from various rat tissues.","9418940",136]
["astaxanthine","astaxanthine","C005948","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,1,1992,"1342638","Isolation of astaxanthin over-producing mutants of Phaffia rhodozyma and their fermentation kinetics.","1342638",136]
["Atenolol","Atenolol","D001262","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1983,"6619241","Rapid high-performance liquid chromatographic method for the measurement of atenolol in plasma using UV detection.","6619241",136]
["Atorvastatin Calcium","Atorvastatin Calcium","D000069059","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2006,"16849589","Chemoprevention of familial adenomatous polyposis by low doses of atorvastatin and celecoxib given individually and in combination to APCMin mice.","16849589",136]
["Atovaquone","Atovaquone","D053626","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27531676","Gene expression-based discovery of atovaquone as a STAT3 inhibitor and anticancer agent.","27531676",136]
["Atrazine","Atrazine","D001280","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2003,"14568710","A new assay format for electrochemical immunosensors: polyelectrolyte-based separation on membrane carriers combined with detection of peroxidase activity by pH-sensitive field-effect transistor.","14568710",136]
["Atropine","Atropine","D001285","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,1978,"99916","Toxic encephalopathy with hippocampal lesions.","99916",136]
["aurapten","aurapten","C105832","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2017,"28675489","Synergy between Auraptene, Ionizing Radiation, and Anticancer Drugs in Colon Adenocarcinoma Cells.","28675489",136]
["Avemar","Avemar","C113915","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"19212640","Avemar, a nontoxic fermented wheat germ extract, attenuates the growth of sensitive and 5-FdUrd/Ara-C cross-resistant H9 human lymphoma cells through induction of apoptosis.","19212640",136]
["azatadine","azatadine","C006656","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1987,"2881936","High-performance liquid chromatographic assay for azatadine in human urine.","2881936",136]
["azelastine","azelastine","C020976","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Nasal Mucosa","D009297","Nasal Mucosa",1,2,2017,"27623823","Effect of budesonide and azelastine on histamine signaling regulation in human nasal epithelial cells.","27623823",136]
["Azithromycin","Azithromycin","D017963","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"20544676","Efficacy and safety of short-duration topical treatment with azithromycin oil-based eyedrops in an experimental model of corneal refractive surgery.","20544676",136]
["Azoxymethane","Azoxymethane","D001397","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20143104","Conjugated linoleic acid suppresses colon carcinogenesis in azoxymethane-pretreated rats with long-term feeding of diet containing beef tallow.","20143104",136]
["bafilomycin A1","bafilomycin A1","C040929","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2003,"14561721","Vacuolar H+-ATPase inhibitor induces apoptosis via lysosomal dysfunction in the human gastric cancer cell line MKN-1.","14561721",136]
["bafilomycin A1","bafilomycin A1","C040929","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2002,"12177126","Characterization of berberine transport into Coptis japonica cells and the involvement of ABC protein.","12177126",136]
["bagasse","bagasse","C027433","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2009,"19656543","Adsorption of Cu(II), Cd(II) and Pb(II) from aqueous single metal solutions by succinylated twice-mercerized sugarcane bagasse functionalized with triethylenetetramine.","19656543",136]
["baicalein","baicalein","C006680","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"25130856","Differential effects of baicalein and its sulfated derivatives in inhibiting proliferation of human breast cancer MCF-7 cells.","25130856",136]
["baicalin","baicalin","C038044","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2013,"23717975","[Study on in situ intestinal absorption of baicalin contained in Tiangou Jiangya capsules].","23717975",136]
["baohuoside I","baohuoside I","C060988","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"26981534","Optimized Biotransformation of Icariin into Icariside II by β-Glucosidase from Trichoderma viride Using Central Composite Design Method.","26981534",136]
["BAY 11-7085","BAY 11-7085","C416282","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2008,"18025832","Agents blocking the nuclear factor-kappaB pathway are effective inhibitors of endometriosis in an in vivo experimental model.","18025832",136]
["BCG Vaccine","BCG Vaccine","D001500","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2002,"12490125","[A study on the use of mycobacterium vaccine in the treatment of tuberculous pleurisy].","12490125",136]
["Beclomethasone","Beclomethasone","D001507","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Nasal Mucosa","D009297","Nasal Mucosa",1,2,1982,"6812468","The effects of disodium cromoglycate and beclomethasone dipropionate on the late nasal mucosa response to allergen challenge.","6812468",136]
["Bendamustine Hydrochloride","Bendamustine Hydrochloride","D000069461","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"26701728","CD69 expression potentially predicts response to bendamustine and its modulation by ibrutinib or idelalisib enhances cytotoxic effect in chronic lymphocytic leukemia.","26701728",136]
["benphothiamine","benphothiamine","C013835","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2009,"19768736","Thiamine and benfotiamine prevent apoptosis induced by high glucose-conditioned extracellular matrix in human retinal pericytes.","19768736",136]
["Bentonite","Bentonite","D001546","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2011,"21918750","Sorption speciation of nickel(II) onto Ca-montmorillonite: batch, EXAFS techniques and modeling.","21918750",136]
["Bentonite","Bentonite","D001546","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1979,"43459","[Effect of the salt content and pH of the dispersion medium on Escherichia coli phage T2 sorption by natural Cherkassy montmorrillonite].","43459",136]
["Benzene","Benzene","D001554","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2003,"12928149","Mechanisms of benzene-induced hematotoxicity and leukemogenicity: cDNA microarray analyses using mouse bone marrow tissue.","12928149",136]
["benzeneboronic acid","benzeneboronic acid","C010686","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1993,"8102883","Immobilized phenylboronic acids for the selective extraction of beta-blocking drugs from aqueous solution and plasma.","8102883",136]
["Benzo(a)pyrene","Benzo(a)pyrene","D001564","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2002,"12819374","Effects of benzo[a]pyrene, 2-bromopropane, phenol and 2,3,7,8-tetrachlorodibenzo-p-dioxin on proinflammatory cytokines gene expression by mice spleen cells.","12819374",136]
["Benzo(a)pyrene","Benzo(a)pyrene","D001564","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"24389667","Isolation and characterization of pyrene and benzo[a]pyrene-degrading Klebsiella pneumonia PL1 and its potential use in bioremediation.","24389667",136]
["Benzo(a)pyrene","Benzo(a)pyrene","D001564","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,1,2007,"16885195","Expression of human glutathione S-transferase P1 confers resistance to benzo[a]pyrene or benzo[a]pyrene-7,8-dihydrodiol mutagenesis, macromolecular alkylation and formation of stable N2-Gua-BPDE adducts in stably transfected V79MZ cells co-expressing hCYP1A1.","16885195",136]
["Benzoic Acid","Benzoic Acid","D019817","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1985,"3989683","Effect of diffusion layer pH and solubility on the dissolution rate of pharmaceutical acids and their sodium salts. II: Salicylic acid, theophylline, and benzoic acid.","3989683",136]
["benzoylecgonine","benzoylecgonine","C005618","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2017,"28130907","Monitoring of the stability of cocaine and some metabolites in water and oral fluid by a newly developed CE method.","28130907",136]
["benzylpenicilloic acid","benzylpenicilloic acid","C030990","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1984,"6694069","Epimerization of benzylpenicilloic acid in alkaline media.","6694069",136]
["beraprost","beraprost","C048081","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"26092100","The cAMP-producing agonist beraprost inhibits human vascular smooth muscle cell migration via exchange protein directly activated by cAMP.","26092100",136]
["Berberine","Berberine","D001599","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"26999092","Silver Nanoparticles Exhibit the Dose-Dependent Anti-Proliferative Effect against Human Squamous Carcinoma Cells Attenuated in the Presence of Berberine.","26999092",136]
["Berberine","Berberine","D001599","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28729227","Computational and experimental prediction of molecules involved in the anti-melanoma action of berberine.","28729227",136]
["beta Carotene","beta Carotene","D019207","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2017,"28625776","Beta-carotene preferentially regulates chicken myoblast proliferation withdrawal and differentiation commitment via BCO1 activity and retinoic acid production.","28625776",136]
["beta Carotene","beta Carotene","D019207","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"17995613","Optimization of beta-carotene production by Rhodotorula glutinis using high hydrostatic pressure and response surface methodology.","17995613",136]
["betadex","betadex","C031215","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2001,"11263568","Separation of monomethyl-benz[a]anthracene isomers using cyclodextrin-modified electrokinetic chromatography.","11263568",136]
["betadex","betadex","C031215","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2009,"19586735","Characterization of aspartame-cyclodextrin complexation.","19586735",136]
["beta-hexachlorocyclohexane","beta-hexachlorocyclohexane","C023888","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"19760616","β-Benzene hexachloride induces apoptosis of rat Sertoli cells through generation of reactive oxygen species and activation of JNKs and FasL.","19760616",136]
["Betaine","Betaine","D001622","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2015,"26359029","Maternal gestational betaine supplementation-mediated suppression of hepatic cyclin D2 and presenilin1 gene in newborn piglets is associated with epigenetic regulation of the STAT3-dependent pathway.","26359029",136]
["Betamethasone","Betamethasone","D001623","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Atrophy","D001284","Atrophy",1,2,1973,"4786004","Beclomethasone dipropionate and betamethasone valerate aerosols.","4786004",136]
["beta-solamarine","beta-solamarine","C026609","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22172325","Induction of apoptosis in human hepatoma SMMC-7721 cells by solamargine from Solanum nigrum L.","22172325",136]
["beta-tricalcium phosphate","beta-tricalcium phosphate","C485817","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2006,"16612817","Effect of reinforcement particle size on in vitro behavior of beta-tricalcium phosphate-reinforced high-density polyethylene: a novel orthopedic composite.","16612817",136]
["betulin","betulin","C002503","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25942059","Synthesis of cytotoxic 2,2-difluoroderivatives of dihydrobetulinic acid and allobetulin and study of their impact on cancer cells.","25942059",136]
["betulinic acid","betulinic acid","C002070","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28671831","Mitochondria-Targeted Lupane Triterpenoid Derivatives and Their Selective Apoptosis-Inducing Anticancer Mechanisms.","28671831",136]
["bicyclol","bicyclol","C477843","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"20419542","Involvement of HSP70 in the protection of bicyclol on apoptosis of HepG2 cells intoxicated by d-galactosamine.","20419542",136]
["bifenthrin","bifenthrin","C099952","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2006,"16629136","Use of carboxylesterase activity to remove pyrethroid-associated toxicity to Ceriodaphnia dubia and Hyalella azteca in toxicity identification evaluations.","16629136",136]
["Bilirubin","Bilirubin","D001663","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1975,"234263","Fluorescent dye method for determination of the bilirubin-binding capacity of serum albumin.","234263",136]
["Bilirubin","Bilirubin","D001663","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1983,"6871245","Microsomal conjugation and oxidation of bilirubin.","6871245",136]
["Biopterin","Biopterin","D001708","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1986,"3536512","Biosynthesis of tetrahydrobiopterin. Purification and characterization of 6-pyruvoyl-tetrahydropterin synthase from human liver.","3536512",136]
["Biotin","Biotin","D001710","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20469969","Biotin-directed assembly of targeted modular lipoplexes and their transfection of human hepatoma cells in vitro.","20469969",136]
["biphosphinic palladacycle complex","biphosphinic palladacycle complex","C534987","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24709226","Palladacycle (BPC) antitumour activity against resistant and metastatic cell lines: the relationship with cytosolic calcium mobilisation and cathepsin B activity.","24709226",136]
["bis(tri-n-butyltin)oxide","bis(tri-n-butyltin)oxide","C005961","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2007,"17553608","In vitro immunotoxicity of bis(tri-n-butyltin)oxide (TBTO) studied by toxicogenomics.","17553608",136]
["bisabololoxide A","bisabololoxide A","C548414","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"23873581","Bisabololoxide A, one of the constituents in German chamomile extract, attenuates cell death induced by calcium overload.","23873581",136]
["bisphenol A","bisphenol A","C006780","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2007,"17322771","Estrogen receptor independent neurotoxic mechanism of bisphenol A, an environmental estrogen.","17322771",136]
["bisphenol A","bisphenol A","C006780","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2011,"21428397","Comment on \"Bisphenol A (BPA) in U.S. Food\".","21428397",136]
["BIX 01294","BIX 01294","C518299","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28104027","[Inhibition of G9a attenuates cell proliferation via the mitochondrial apoptosis pathway in lung adenocarcinoma].","28104027",136]
["Blood Glucose","Blood Glucose","D001786","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27614127","Salvianolic acid B improves vascular endothelial function in diabetic rats with blood glucose fluctuations via suppression of endothelial cell apoptosis.","27614127",136]
["Blood Glucose","Blood Glucose","D001786","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1964,"14273184","[EFFECT OF OXYGEN SATURATION AND BLOOD PH ON ERYTHROCYTIC CARBOHYDRATE METABOLISM].","14273184",136]
["Blood Glucose","Blood Glucose","D001786","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1977,"25527","[Nomogram and guide values for computer-directed therapy of azidotic hyperglycemia].","25527",136]
["BMS 181885","BMS 181885","C111853","7_AO",872,7,"Site of Contact Nasal Tumors","Increase","Nasal Cavity","D009296","Nasal Cavity",1,1,1998,"9724572","Absolute bioavailability and dose proportionality of BMS-181885, an antimigraine agent, following the administration of single intranasal doses to cynomolgus monkeys.","9724572",136]
["boric acid","boric acid","C032688","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,1991,"1890547","An outbreak of aflatoxicosis and boric acid poisoning in Malaysia: a clinicopathological study.","1890547",136]
["Bortezomib","Bortezomib","D000069286","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2007,"17222199","Bortezomib disrupts tumour-dendritic cell interactions in myeloma and lymphoma: therapeutic implications.","17222199",136]
["Bortezomib","Bortezomib","D000069286","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"19267218","Bmf is upregulated by PS-341-mediated cell death of glioma cells through JNK phosphorylation.","19267218",136]
["Bortezomib","Bortezomib","D000069286","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23161111","Detrimental effects of proteasome inhibition activity in Drosophila melanogaster: implication of ER stress, autophagy, and apoptosis.","23161111",136]
["Bortezomib","Bortezomib","D000069286","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"24156429","[Effect of PCI-32765 and bortezomib on proliferation and apoptosis of B-cell tumor cell lines and its mechanisms].","24156429",136]
["Bortezomib","Bortezomib","D000069286","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2008,"19383353","Curcumin in combination with bortezomib synergistically induced apoptosis in human multiple myeloma U266 cells.","19383353",136]
["Bortezomib","Bortezomib","D000069286","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2005,"15735676","Molecular characterization of PS-341 (bortezomib) resistance: implications for overcoming resistance using lysophosphatidic acid acyltransferase (LPAAT)-beta inhibitors.","15735676",136]
["brefelamide","brefelamide","C510885","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2005,"16238318","Isolation and synthesis of a new aromatic compound, brefelamide, from dictyostelium cellular slime molds and its inhibitory effect on the proliferation of astrocytoma cells.","16238318",136]
["brine","brine","C017082","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2006,"17195482","Feasibility study of using brine for carbon dioxide capture and storage from fixed sources.","17195482",136]
["Bromcresol Green","Bromcresol Green","D001961","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1993,"8518325","Spectrophotometric determination of molsidomine in pharmaceutical formulations using bromocresol green.","8518325",136]
["Bromosuccinimide","Bromosuccinimide","D001974","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1976,"10243","Chemical modification of two tryptophan residues abolishes the catalytic activity of aminoacylase.","10243",136]
["brucine","brucine","C083806","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"22160569","The interaction of blood proteins with brucine.","22160569",136]
["BSS solution","BSS solution","C030660","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2006,"17081903","After-cataract evaluation after using balanced salt solution, distilled deionized water, and 5-fluorouracil with a sealed-capsule irrigation device in the eyes of 4-week-old rabbits.","17081903",136]
["bufalin","bufalin","C022777","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2009,"19039527","Microarray and biochemical analysis of bufalin-induced apoptosis of HL-60 Cells.","19039527",136]
["Bumetanide","Bumetanide","D002034","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1986,"3714957","An investigation of [3H]bumetanide uptake in a cultured renal cell line (MDCK).","3714957",136]
["Bupivacaine","Bupivacaine","D002045","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2006,"16076540","Liquid-phase microextraction combined with high-performance liquid chromatography for the determination of local anaesthetics in human urine.","16076540",136]
["Bupivacaine","Bupivacaine","D002045","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2016,"26421809","Modification of Bupivacaine-Induced Myotoxicity with Dantrolene and Caffeine In Vitro.","26421809",136]
["butein","butein","C040918","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22114764","Butein induces apoptosis and inhibits prostate tumor growth in vitro and in vivo.","22114764",136]
["Butylhydroxybutylnitrosamine","Butylhydroxybutylnitrosamine","D002085","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1986,"3756839","Promoting effects of various agents in rat urinary bladder carcinogenesis initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine.","3756839",136]
["Butyric Acid","Butyric Acid","D020148","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2004,"15520174","Overexpression of histone deacetylase 1 confers resistance to sodium butyrate-mediated apoptosis in melanoma cells through a p53-mediated pathway.","15520174",136]
["Butyric Acid","Butyric Acid","D020148","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1991,"2065907","Mechanism of short-chain fatty acid uptake by apical membrane vesicles of rat distal colon.","2065907",136]
["C 1305","C 1305","C488734","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2006,"16970926","Induction of G2/M phase arrest and apoptosis of human leukemia cells by potent antitumor triazoloacridinone C-1305.","16970926",136]
["Cadaverine","Cadaverine","D002103","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1980,"6156003","Primary amines inhibit recycling of alpha 2M receptors in fibroblasts.","6156003",136]
["Cadmium Chloride","Cadmium Chloride","D019256","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,1964,"14188425","[APROPOS OF THE INFLUENCE OF CADMIUM CHLORIDE ON THE TESTICLE: RESEARCH IN THE MONKEY MACACUS IRUS F. CUV].","14188425",136]
["cadmium selenide","cadmium selenide","C058667","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2013,"23681155","Differential effects of β-mercaptoethanol on CdSe/ZnS and InP/ZnS quantum dots.","23681155",136]
["caffeic acid phenethyl ester","caffeic acid phenethyl ester","C055494","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2005,"16254262","In vivo effects of caffeic acid phenethyl ester on myocardial ischemia-reperfusion injury and apoptotic changes in rats.","16254262",136]
["Caffeine","Caffeine","D002110","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24836650","Differential effects of caffeine on hair shaft elongation, matrix and outer root sheath keratinocyte proliferation, and transforming growth factor-β2/insulin-like growth factor-1-mediated regulation of the hair cycle in male and female human hair follicles in vitro.","24836650",136]
["Caffeine","Caffeine","D002110","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,1993,"8512808","Caffeine potentiates the lethality of tumour necrosis factor in cancer cells.","8512808",136]
["Caffeine","Caffeine","D002110","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,2,1995,"7761573","Mutant quantity and quality in mammalian cells (AL) exposed to cesium-137 gamma radiation: effect of caffeine.","7761573",136]
["Calcimycin","Calcimycin","D000001","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1976,"3212","Ionophore A23187: the effect of H+ concentration on complex formation with divalent and monovalent cations and the demonstration of K+ transport in mitochondria mediated by A23187.","3212",136]
["Calcitriol","Calcitriol","D002117","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2009,"19584236","EB1089 inhibits the parathyroid hormone-related protein-enhanced bone metastasis and xenograft growth of human prostate cancer cells.","19584236",136]
["Calcitriol","Calcitriol","D002117","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25510900","Calcitriol and its analogues enhance the antiproliferative activity of gefitinib in breast cancer cells.","25510900",136]
["Calcitriol","Calcitriol","D002117","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"19662683","Cystatin D is a candidate tumor suppressor  gene induced by vitamin D in human  colon cancer cells.","19662683",136]
["calcium aluminate","calcium aluminate","C035219","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2012,"22792830","Contact with wet cement: an unrecognized cause of chemical burn.","22792830",136]
["Calcium Carbonate","Calcium Carbonate","D002119","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2006,"16800667","Double hydrophilic block copolymer controlled growth and self-assembly of CaCO3 multilayered structures at the air/water interface.","16800667",136]
["Calcium Carbonate","Calcium Carbonate","D002119","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2009,"19786291","In situ stabilization of cadmium-, lead-, and zinc-contaminated soil using various amendments.","19786291",136]
["Calcium Carbonate","Calcium Carbonate","D002119","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1994,"7965206","Dietary calcium chloride vs. calcium carbonate reduces urinary pH and phosphorus concentration, improves bone mineralization and depresses kidney calcium level in cats.","7965206",136]
["Calcium Dobesilate","Calcium Dobesilate","D002123","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2006,"16551428","Dobesilate inhibits the activation of signal transducer and activator of transcription 3, and the expression of cyclin D1 and bcl-XL in glioma cells.","16551428",136]
["Calcium Hydroxide","Calcium Hydroxide","D002126","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2011,"21859433","The effects of hyperosmosis or high pH on a dual-species biofilm of Enterococcus faecalis and Pseudomonas aeruginosa: an in vitro study.","21859433",136]
["Calcium Hydroxide","Calcium Hydroxide","D002126","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1985,"3912031","Full thickness burns from ready-mixed cement.","3912031",136]
["Calcium Oxalate","Calcium Oxalate","D002129","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"22200737","Simplified estimates of ion-activity products of calcium oxalate and calcium phosphate in mouse urine.","22200737",136]
["calcium phosphate","calcium phosphate","C020243","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2008,"18333806","Non-viral bone morphogenetic protein 2 transfection of rat dental pulp stem cells using calcium phosphate nanoparticles as carriers.","18333806",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C62083,B62083)","v":"calcium phosphate"},"calcium phosphate","C020243","1_MIE",867,1,"Intracellular pH","Decrease",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J62083,K62083)","v":"Hydrogen-Ion Concentration"},"D006863","Hydrogen-Ion Concentration",2,2,2011,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q62083,Q62083)","v":"21851066"},"Polymer brush controlled bioinspired calcium phosphate mineralization and bone cell growth.","21851066",136]
["calcium phosphate","calcium phosphate","C020243","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,3,2016,"26923119","Calcium-phosphate-osteopontin particles for caries control.","26923119",136]
["calcium phosphate, dibasic, dihydrate","calcium phosphate, dibasic, dihydrate","C494366","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2016,"26836293","Controlled mineralisation and recrystallisation of brushite within alginate hydrogels.","26836293",136]
["calcium silicate","calcium silicate","C031293","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23252889","Mechanistic study of the covalent loading of paclitaxel via disulfide linkers for controlled drug release.","23252889",136]
["calcium silicate","calcium silicate","C031293","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2011,"21529922","Development of the foremost light-curable calcium-silicate MTA cement as root-end in oral surgery. Chemical-physical properties, bioactivity and biological behavior.","21529922",136]
["Calcium, Dietary","Calcium, Dietary","D002136","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1964,"14169116","DIRECT OBSERVATION OF SECRETORY PUMPING IN VITRO OF THE RABBIT EYE CILIARY PROCESSES. INFLUENCE OF ION MILIEU AND CARBONIC ANHYDRASE INHIBITION.","14169116",136]
["calix(6)arene","calix(6)arene","C476540","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2015,"25404418","Molecular-recognition-assisted pKa shifts and metal-ion-induced fluorescence regeneration in p-sulfonatocalix[6]arene-encapsulated acridine.","25404418",136]
["Camptothecin","Camptothecin","D002166","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2002,"11901212","Induction of biphasic DNA double strand breaks and activation of multiple repair protein complexes by DNA topoisomerase I drug 7-ethyl-10-hydroxy-camptothecin.","11901212",136]
["Camptothecin","Camptothecin","D002166","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2002,"12453851","Irinotecan: mechanisms of tumor resistance and novel strategies for modulating its activity.","12453851",136]
["Camptothecin","Camptothecin","D002166","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"21463374","Irinotecan-induced alterations in intestinal cell kinetics and extracellular matrix component expression in the Dark Agouti rat.","21463374",136]
["Camptothecin","Camptothecin","D002166","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2008,"18218022","Effects of isocamptothecin, a novel camptothecin analogue, on proliferation, apoptosis and telomerase activity in HaCaT cells.","18218022",136]
["Camptothecin","Camptothecin","D002166","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25941985","Camptothecin suppresses expression of matrix metalloproteinase-9 and vascular endothelial growth factor in DU145 cells through PI3K/Akt-mediated inhibition of NF-κB activity and Nrf2-dependent induction of HO-1 expression.","25941985",136]
["Camptothecin","Camptothecin","D002166","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"29377649","Development of pH-Sensitive Cationic PEGylated Solid Lipid Nanoparticles for Selective Cancer-Targeted Therapy.","29377649",136]
["Camptothecin","Camptothecin","D002166","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2011,"21994408","Looking through the vascular normalization window: timing antiangiogenic treatment and chemotherapy with (99m)Tc-annexin A5.","21994408",136]
["Canola Oil","Canola Oil","D000074262","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"25145444","Enhanced biotransformation of dehydroepiandrosterone to 3β,7α,15α-trihydroxy-5-androsten-17-one with Gibberella intermedia CA3-1 by natural oils addition.","25145444",136]
["Capsaicin","Capsaicin","D002211","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2002,"12418083","Cell death of primary afferent nerve cells in neonatal mice treated with capsaicin.","12418083",136]
["Capsaicin","Capsaicin","D002211","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2007,"17295509","Effects of capsaicin on induction of apoptosis and inhibition of adipogenesis in 3T3-L1 cells.","17295509",136]
["Capsaicin","Capsaicin","D002211","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,1,2016,"26719417","Understanding TRPV1 activation by ligands: Insights from the binding modes of capsaicin and resiniferatoxin.","26719417",136]
["capsazepine","capsazepine","C071423","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1997,"9247067","Enhancement of rat trigeminal ganglion neuron responses to piperine in a low-pH environment and block by capsazepine.","9247067",136]
["Carbamazepine","Carbamazepine","D002220","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2006,"16910300","[Fulminant liver failure in a patient on carbamazepine and levetiracetam treatment associated with status epilepticus].","16910300",136]
["carbendazim","carbendazim","C006698","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,1,2007,"17955449","Characterization and fitness of carbendazim-resistant strains of Fusarium graminearum (wheat scab).","17955449",136]
["Carbenicillin","Carbenicillin","D002228","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,1974,"4215436","Experimental pseudomonas osteomyelitis: treatment with sisomicin and carbenicillin.","4215436",136]
["Carbon Dioxide","Carbon Dioxide","D002245","1_MIE",867,1,"Intracellular pH","Decrease","Acid-Base Equilibrium","D000136","Acid-Base Equilibrium",2,3,1957,"13444301","Effects of aminophylline and diamox alone and together on respiration and acid-base balance and on respiratory response to carbon dioxide in pulmonary emphysema.","13444301",136]
["Carbon Dioxide","Carbon Dioxide","D002245","1_MIE",867,1,"Intracellular pH","Decrease","Acid-Base Equilibrium","D000136","Acid-Base Equilibrium",2,2,1964,"14164778","THE INFLUENCE OF ETHANOL ON THE ACID-BASE BALANCE OF THE BLOOD IN MAN AND RAT.","14164778",136]
["Carbon Dioxide","Carbon Dioxide","D002245","1_MIE",867,1,"Intracellular pH","Decrease","Acid-Base Equilibrium","D000136","Acid-Base Equilibrium",2,2,1973,"4196690","The effect of arterial PCO 2  on relative retinal blood flow in monkeys.","4196690",136]
["Carbon Dioxide","Carbon Dioxide","D002245","1_MIE",867,1,"Intracellular pH","Decrease","Acid-Base Equilibrium","D000136","Acid-Base Equilibrium",2,2,1974,"4833995","A study of factors affecting renal bicarbonate reabsorption.","4833995",136]
["Carbon Dioxide","Carbon Dioxide","D002245","1_MIE",867,1,"Intracellular pH","Decrease","Acid-Base Equilibrium","D000136","Acid-Base Equilibrium",2,2,1969,"5765967","Hyperventilation in obstetrics.","5765967",136]
["Carbon Dioxide","Carbon Dioxide","D002245","1_MIE",867,1,"Intracellular pH","Decrease","Acid-Base Equilibrium","D000136","Acid-Base Equilibrium",2,2,1967,"6031324","pH and pCO2 in capillary blood from the ear-lobe.","6031324",136]
["Carbon Dioxide","Carbon Dioxide","D002245","1_MIE",867,1,"Intracellular pH","Decrease","Acid-Base Imbalance","D000137","Acid-Base Imbalance",2,2,1983,"6416067","Evaluation of the bicarbonate buffer system. Does the pK' really vary in the blood?","6416067",136]
["Carbon Dioxide","Carbon Dioxide","D002245","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1999,"10458739","Bicarbonate concentration and osmolality are key determinants in the inhibition of CHO cell polysialylation under elevated pCO(2) or pH.","10458739",136]
["Carbon Dioxide","Carbon Dioxide","D002245","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1976,"13472","Calculations for pH during CO2 and O2 exchange with blood.","13472",136]
["Carbon Dioxide","Carbon Dioxide","D002245","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1963,"14060812","RELATION OF BLOOD PH AND CO2 TO CENTRAL STIMULATORY EFFECTS OF SALINE ON DOGS.","14060812",136]
["Carbon Dioxide","Carbon Dioxide","D002245","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1965,"14311302","[RESPONSE OF VENTILATION TO PERFUSION OF CHEMORECEPTORS IN THE CAROTID AREA ISOLATED FROM THE CIRCULATION, WITH SOLUTIONS IN WHICH CO2 PRESSURE AND HYDROGEN ION-CONCENTRATION ARE VARIED].","14311302",136]
["Carbon Dioxide","Carbon Dioxide","D002245","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1991,"1682843","Tissue lactate content and tissue PCO2 in complete brain ischaemia: implications for compartmentation of H+.","1682843",136]
["Carbon Dioxide","Carbon Dioxide","D002245","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2009,"19129527","Arterial blood gases and oxygen content in climbers on Mount Everest.","19129527",136]
["Carbon Dioxide","Carbon Dioxide","D002245","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1972,"20465483","Per cent pH regulation as an index of CO₂ buffering in vivo and in vitro.","20465483",136]
["Carbon Dioxide","Carbon Dioxide","D002245","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2011,"22082296","Proton transfer from 2-naphthol to aliphatic amines in supercritical CO2.","22082296",136]
["Carbon Dioxide","Carbon Dioxide","D002245","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1977,"23823","Intraerythrocyte pH, pCO2 and the hexose monophosphate shunt.","23823",136]
["Carbon Dioxide","Carbon Dioxide","D002245","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1989,"2493743","Effect of CO2 on pHi in rabbit parietal, chief, and surface cells.","2493743",136]
["Carbon Dioxide","Carbon Dioxide","D002245","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2015,"25841887","Enhancing the efficacy of electrolytic chlorination for ballast water treatment by adding carbon dioxide.","25841887",136]
["Carbon Dioxide","Carbon Dioxide","D002245","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1988,"2846500","A micromethod for measuring carbonic anhydrase activity using 18O exchange between CO2 and H2O.","2846500",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C69059,B69059)","v":"Carbon Dioxide"},"Carbon Dioxide","D002245","1_MIE",867,1,"Intracellular pH","Decrease",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J69059,K69059)","v":"Hydrogen-Ion Concentration"},"D006863","Hydrogen-Ion Concentration",2,2,1978,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q69059,Q69059)","v":"31756"},"Effects of acute hypercapnia and hypocapnia on plasma and red cell potassium, blood lactate and base excess in man during anesthesia.","31756",136]
["Carbon Dioxide","Carbon Dioxide","D002245","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1966,"4163348","The effect of ion exchange resins on CO2 production in anaerobic respiration of yeasts.","4163348",136]
["Carbon Dioxide","Carbon Dioxide","D002245","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1974,"4469097","Functional responses of diaphragm muscle in the rat to varying PCO2 levels and helium content in hyperbaric atmospheres.","4469097",136]
["Carbon Dioxide","Carbon Dioxide","D002245","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1971,"4932048","In vivo CO2 buffer curves of arterial and mixed venous blood.","4932048",136]
["Carbon Dioxide","Carbon Dioxide","D002245","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1966,"5338825","The physiology of excystment of the metacercaria of Fasciola hepatica L.","5338825",136]
["Carbon Dioxide","Carbon Dioxide","D002245","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1970,"5428335","The marriage of Fick and Bohr arranged by computer.","5428335",136]
["Carbon Dioxide","Carbon Dioxide","D002245","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1968,"5753166","Blood gas tensions and pH values in the normal thoroughbred foal at birth and in the following 42h.","5753166",136]
["Carbon Dioxide","Carbon Dioxide","D002245","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1983,"6409979","Renal acid excretion in the domestic fowl.","6409979",136]
["Carbon Dioxide","Carbon Dioxide","D002245","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1984,"6439730","Variability in CO2, O2, and pH levels in blood culture bottles from five different manufacturers.","6439730",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C70467,B70467)","v":"Carbon Dioxide"},"Carbon Dioxide","D002245","1_MIE",867,1,"Intracellular pH","Decrease",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J70467,K70467)","v":"Hydrogen-Ion Concentration"},"D006863","Hydrogen-Ion Concentration",2,2,1982,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q70467,Q70467)","v":"6821135"},"[Preliminary studies on continuous monitoring of blood gases and pH in extracorporeal circulation].","6821135",136]
["Carbon Dioxide","Carbon Dioxide","D002245","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1997,"9112881","Effect of carbon dioxide-enriched water and fresh water on the cutaneous microcirculation and oxygen tension in the skin of the foot.","9112881",136]
["Carbon Dioxide","Carbon Dioxide","D002245","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2016,"27748709","Investigating the Vascular Phenotype of Subcutaneously and Orthotopically Propagated PC3 Prostate Cancer Xenografts Using Combined Carbogen Ultrasmall Superparamagnetic Iron Oxide MRI.","27748709",136]
["Carbon Disulfide","Carbon Disulfide","D002246","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24582363","Carbon disulfide induces rat testicular injury via mitochondrial apoptotic pathway.","24582363",136]
["Carbon Monoxide","Carbon Monoxide","D002248","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"26993595","Alterations of tumor microenvironment by carbon monoxide impedes lung cancer growth.","26993595",136]
["Carbon Monoxide","Carbon Monoxide","D002248","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2016,"27424489","Analysis of the pH-dependent thermodynamic stability, local motions, and microsecond folding kinetics of carbonmonoxycytochrome c.","27424489",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C71491,B71491)","v":"Carbon Monoxide"},"Carbon Monoxide","D002248","1_MIE",867,1,"Intracellular pH","Decrease",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J71491,K71491)","v":"Hydrogen-Ion Concentration"},"D006863","Hydrogen-Ion Concentration",2,2,1967,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q71491,Q71491)","v":"6049439"},"Studies on the equilibria and kinetics of the reactions of peroxidases with ligands. 3. The dissociation of carbon monoxide from carbon monoxide ferro-horseradish peroxidase.","6049439",136]
["Carbon Tetrachloride","Carbon Tetrachloride","D002251","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2010,"20678221","Lack of guanylate cyclase C results in increased mortality in mice following liver injury.","20678221",136]
["Carbon Tetrachloride","Carbon Tetrachloride","D002251","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,1957,"13445839","[Fatal necrosis of liver &amp; kidneys after poisoning by carbon tetrachloride &amp; dichloroethane; 5 case reports of the severe liver-kidney syndrome, one fatal].","13445839",136]
["Carbon Tetrachloride","Carbon Tetrachloride","D002251","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,1983,"6678618","Correlations between common tests for assessment of liver damage: indices of the hepatoprotective activity of promethazine in carbon tetrachloride hepatotoxicity.","6678618",136]
["Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone","Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone","D002259","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2002,"11810202","FCCP depolarizes plasma membrane potential by activating proton and Na+ currents in bovine aortic endothelial cells.","11810202",136]
["Carboplatin","Carboplatin","D016190","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,1998,"9891512","Carboplatin-induced cell death in model prostate cancer systems.","9891512",136]
["carbopol 940","carbopol 940","C006903","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2003,"12480279","Equilibrium properties and mechanism of kinetic release of metoclopramide from carbomer hydrogels.","12480279",136]
["carbopol 940","carbopol 940","C006903","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2016,"27264646","Immobilization of horseradish peroxidase on amidoximated acrylic polymer activated by cyanuric chloride.","27264646",136]
["carboxymethyl-beta-cyclodextrin","carboxymethyl-beta-cyclodextrin","C441457","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2016,"27372416","Enantioselective extraction of phenylsuccinic acid in aqueous two-phase systems based on acetone and β-cyclodextrin derivative: Modeling and optimization through response surface methodology.","27372416",136]
["Carboxymethylcellulose Sodium","Carboxymethylcellulose Sodium","D002266","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2015,"24670096","Design, development and characterization of buccal bioadhesive films of Doxepin for treatment of odontalgia.","24670096",136]
["cardamonin","cardamonin","C436747","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24211271","Pre-treatment with cardamonin protects against cisplatin-induced nephrotoxicity in rats: impact on NOX-1, inflammation and apoptosis.","24211271",136]
["Carnitine","Carnitine","D002331","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2009,"18249387","L-carnitine decreases DNA damage and improves the in vitro blastocyst development rate in mouse embryos.","18249387",136]
["carnosol","carnosol","C068623","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,1,2012,"22374940","Carnosol, a constituent of Zyflamend, inhibits aryl hydrocarbon receptor-mediated activation of CYP1A1 and CYP1B1 transcription and mutagenesis.","22374940",136]
["Carrageenan","Carrageenan","D002351","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"26098663","Antitumor and Adjuvant Activity of λ-carrageenan by Stimulating Immune Response in Cancer Immunotherapy.","26098663",136]
["carvedilol","carvedilol","C043211","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2011,"21624291","[Effects of carvedilol on cardiomyocyte apoptosis in autoimmune myocarditis in mice].","21624291",136]
["catalpol","catalpol","C078040","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28785376","Neuroprotection of Catalpol for Experimental Acute Focal Ischemic Stroke: Preclinical Evidence and Possible Mechanisms of Antioxidation, Anti-Inflammation, and Antiapoptosis.","28785376",136]
["Catechin","Catechin","D002392","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2007,"17483343","A novel prodrug of the green tea polyphenol (-)-epigallocatechin-3-gallate as a potential anticancer agent.","17483343",136]
["Catechin","Catechin","D002392","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2008,"18546267","Synergistic inhibition of head and neck tumor growth by green tea (-)-epigallocatechin-3-gallate and EGFR tyrosine kinase inhibitor.","18546267",136]
["Catechin","Catechin","D002392","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23715786","Active extracts of black tea (Camellia Sinensis) induce apoptosis of PC-3 prostate cancer cells via mitochondrial dysfunction.","23715786",136]
["Catechin","Catechin","D002392","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28103535","Down-regulation of histone deacetylase 4, -5 and -6 as a mechanism of synergistic enhancement of apoptosis in human lung cancer cells treated with the combination of a synthetic retinoid, Am80 and green tea catechin.","28103535",136]
["Catechin","Catechin","D002392","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"20446926","(-)-Epigallocatechin-3-gallate down-regulates EGFR, MMP-2, MMP-9 and EMMPRIN and inhibits the invasion of MCF-7 tamoxifen-resistant cells.","20446926",136]
["Catechin","Catechin","D002392","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22312277","Antiproliferative and apoptotic effects triggered by Grape Seed Extract (GSE) versus epigallocatechin and procyanidins on colon cancer cell lines.","22312277",136]
["Catechin","Catechin","D002392","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2016,"26916663","Epigallocatechin-3-Gallate Inhibits Ethanol-Induced Apoptosis Through Neurod1 Regulating CHOP Expression in Pancreatic β-Cells.","26916663",136]
["Catechin","Catechin","D002392","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2013,"24008975","Epigallocatechin-3-gallate inhibits IGF-I-stimulated lung cancer angiogenesis through downregulation of HIF-1α and VEGF expression.","24008975",136]
["CCT007093","CCT007093","C000591540","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2014,"24126074","Off-target response of a Wip1 chemical inhibitor in skin keratinocytes.","24126074",136]
["CD 437","CD 437","C099555","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,1999,"10445853","Implication of c-Myc in apoptosis induced by the retinoid CD437 in human lung carcinoma cells.","10445853",136]
["CD3 Complex","CD3 Complex","D017252","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2001,"11672928","Interleukin-2 fusion protein with anti-CD3 single-chain Fv (sFv) selectively protects T cells from dexamethasone-induced apoptosis.","11672928",136]
["CD8 antigen, alpha chain","CD8 antigen, alpha chain","C409469","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2014,"24257693","Peripheral blood CD8αα+CD11c+MHC-II+CD3- cells attenuate autoimmune glomerulonephritis in rats.","24257693",136]
["Cefixime","Cefixime","D020682","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2001,"11561098","Flavonoids with epidermal growth factor-receptor tyrosine kinase inhibitory activity stimulate PEPT1-mediated cefixime uptake into human intestinal epithelial cells.","11561098",136]
["Cefoperazone","Cefoperazone","D002438","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"18161321","[Separation of cefoperazone and its S-isomer and other related substances by micellar electrokinetic capillary chromatography].","18161321",136]
["Celecoxib","Celecoxib","D000068579","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2004,"14973075","3-phosphoinositide-dependent protein kinase-1/Akt signaling represents a major cyclooxygenase-2-independent target for celecoxib in prostate cancer cells.","14973075",136]
["Celecoxib","Celecoxib","D000068579","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23422093","Chemoprevention of head and neck cancer by simultaneous blocking of epidermal growth factor receptor and cyclooxygenase-2 signaling pathways: preclinical and clinical studies.","23422093",136]
["Celecoxib","Celecoxib","D000068579","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"26009874","Mcl-1 is an important therapeutic target for oral squamous cell carcinomas.","26009874",136]
["Celecoxib","Celecoxib","D000068579","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23268707","Different cell cycle modulation by celecoxib at different concentrations.","23268707",136]
["Cellophane","Cellophane","D002476","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2000,"10903039","Immobilized biomolecules on plasma functionalized cellophane. I. Covalently attached alpha-chymotrypsin.","10903039",136]
["Cellulose","Cellulose","D002482","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2002,"12413454","Hydroxyethylcellulose as an effective polymer network for DNA analysis in uncoated glass microchips: optimization and application to mutation detection via heteroduplex analysis.","12413454",136]
["Cellulose","Cellulose","D002482","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2003,"12944136","In vitro iontophoretic transport of ketorolac: synthetic membrane as a barrier.","12944136",136]
["Cellulose","Cellulose","D002482","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2010,"21085176","Free-standing mesoporous silica films with tunable chiral nematic structures.","21085176",136]
["Cellulose","Cellulose","D002482","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"24793114","Flocculation characteristics of polyacrylamide grafted cellulose from Phyllostachys heterocycla: An efficient and eco-friendly flocculant.","24793114",136]
["Cellulose","Cellulose","D002482","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1987,"3501939","[Penicillin-selective electrode based on a cellulose membrane with immobilized enzyme].","3501939",136]
["Cellulose","Cellulose","D002482","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1998,"9627380","Improving fermentation performance of recombinant Zymomonas in acetic acid-containing media.","9627380",136]
["Cellulose, Oxidized","Cellulose, Oxidized","D002483","7_AO",872,7,"Site of Contact Nasal Tumors","Increase","Nose","D009666","Nose",1,1,1949,"18112696","Rhinologic use of oxidized cellulose gauze.","18112696",136]
["cepharanthine","cepharanthine","C006947","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2018,"29024815","Identification of a novel autophagic inhibitor cepharanthine to enhance the anti-cancer property of dacomitinib in non-small cell lung cancer.","29024815",136]
["cercosporamide","cercosporamide","C085452","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27662474","Inhibition of eukaryotic initiation factor 4E phosphorylation by cercosporamide selectively suppresses angiogenesis, growth and survival of human hepatocellular carcinoma.","27662474",136]
["cetrimonium","cetrimonium","C004322","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2011,"21935586","Studies on the zymogram method for the detection of pectinolytic activities using CTAB.","21935586",136]
["CH 150","CH 150","C045845","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1985,"4013753","[Stability tests of a new pyrido (1.2-a) pyrimidine derivative (CH-150). I. Thermal decomposition].","4013753",136]
["Chalcone","Chalcone","D002599","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"25286005","Flavokawain A induces apoptosis in MCF-7 and MDA-MB231 and inhibits the metastatic process in vitro.","25286005",136]
["chelerythrine","chelerythrine","C016299","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,1996,"8665499","Protein kinase C inhibition induces apoptosis and ceramide production through activation of a neutral sphingomyelinase.","8665499",136]
["Chenodeoxycholic Acid","Chenodeoxycholic Acid","D002635","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1982,"7147164","Search for adaptive cytoprotection in canine gastric mucosa.","7147164",136]
["Chitin","Chitin","D002686","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2012,"22241684","Chitin microparticles for the control of intestinal inflammation.","22241684",136]
["Chitin","Chitin","D002686","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2005,"15993297","Equilibrium, kinetic and thermodynamic studies on the adsorption of phenol onto chitin.","15993297",136]
["Chitin","Chitin","D002686","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"22528307","Chitinolytic enzymes of the rumen ciliate Eudiplodinium maggii.","22528307",136]
["Chitosan","Chitosan","D048271","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2004,"15046887","A preliminary study on chitosan and gelatin polyelectrolyte complex cytocompatibility by cell cycle and apoptosis analysis.","15046887",136]
["Chitosan","Chitosan","D048271","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2004,"15178016","Calorimetric studies of the action of chitosan-N-2-hydroxypropyl trimethyl ammonium chloride on the growth of microorganisms.","15178016",136]
["Chitosan","Chitosan","D048271","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"19634677","[Preparation of chitosan/hydroxyapatite membrane and its effect on cell culture].","19634677",136]
["Chitosan","Chitosan","D048271","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21235582","Platelet lysate formulations based on mucoadhesive polymers for the treatment of corneal lesions.","21235582",136]
["Chitosan","Chitosan","D048271","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24052168","Effects of carbon nanotubes in a chitosan/collagen-based composite on mouse fibroblast cell proliferation.","24052168",136]
["Chitosan","Chitosan","D048271","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"26716193","Improving Antitumor Activity with N-Trimethyl Chitosan Entrapping Camptothecin in Colon Cancer and Lung Cancer.","26716193",136]
["Chitosan","Chitosan","D048271","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2017,"28157717","Structure and properties of polycaprolactone/chitosan nonwovens tailored by solvent systems.","28157717",136]
["Chitosan","Chitosan","D048271","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1992,"1369055","Continuous chitosan hydrolyzate production by immobilized chitosanolytic enzyme from Enterobacter sp. G-1.","1369055",136]
["Chitosan","Chitosan","D048271","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"16999995","Synthesis and characterization of chitosan-g-poly(ethylene glycol)-folate as a non-viral carrier for tumor-targeted gene delivery.","16999995",136]
["Chitosan","Chitosan","D048271","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2009,"19022285","Rapid microwave synthesis of chitosan modified carbon nanotube composites.","19022285",136]
["Chitosan","Chitosan","D048271","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2009,"19621052","[Stabilization of alkaline proteinase and cellulases via complex formation with chitosan for use as detergent components].","19621052",136]
["Chitosan","Chitosan","D048271","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2011,"21290595","A pH-sensitive chitosan-tripolyphosphate hydrogel beads for controlled glipizide delivery.","21290595",136]
["Chitosan","Chitosan","D048271","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2013,"23044153","Controllable antioxidative xylan-chitosan Maillard reaction products used for lipid food storage.","23044153",136]
["Chitosan","Chitosan","D048271","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2013,"23865795","Rheological study of chitosan/polyol-phosphate systems: influence of the polyol part on the thermo-induced gelation mechanism.","23865795",136]
["Chitosan","Chitosan","D048271","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2015,"26230052","Cell outer membrane mimetic chitosan nanoparticles: preparation, characterization and cytotoxicity.","26230052",136]
["Chitosan","Chitosan","D048271","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2015,"26406548","Complex coacervation of hyaluronic acid and chitosan: effects of pH, ionic strength, charge density, chain length and the charge ratio.","26406548",136]
["Chitosan","Chitosan","D048271","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2017,"28189812","Trimethyl chitosan based conjugates for oral and intravenous delivery of paclitaxel.","28189812",136]
["Chitosan","Chitosan","D048271","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2004,"15255151","Changes in catalase activity in potato tubers, induced by immunoregulators.","15255151",136]
["Chlorambucil","Chlorambucil","D002699","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1971,"5560689","Protection of chymotrypsin from inactivation by a nitrogen mustard antitumor drug by prior acylation of the active center.","5560689",136]
["chloramine","chloramine","C030816","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"17270234","Factors affecting formation of haloacetonitriles, haloketones, chloropicrin and cyanogen halides during chloramination.","17270234",136]
["Chlordiazepoxide","Chlordiazepoxide","D002707","1_MIE",867,1,"Intracellular pH","Decrease","Acid-Base Equilibrium","D000136","Acid-Base Equilibrium",2,3,2003,"14561468","Monoterpenes affect chlorodiazepoxide-micelle interaction through micellar dipole potential modifications.","14561468",136]
["chlorhexidine gluconate","chlorhexidine gluconate","C010882","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24090988","A chlorhexidine-loaded biodegradable cellulosic device for periodontal pockets treatment.","24090988",136]
["chlorin p6","chlorin p6","C072905","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"20978762","Conjugation of chlorin p(6) to histamine enhances its cellular uptake and phototoxicity in oral cancer cells.","20978762",136]
["chloroacetic acid","chloroacetic acid","C006972","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2005,"15865156","Biodegradation of monochloroacetic acid used as a sole carbon and energy source by Xanthobacter autotrophicus GJ10 strain in batch and continuous culture.","15865156",136]
["Chlorogenic Acid","Chlorogenic Acid","D002726","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"29243968","Chlorogenic Acid-Enriched Extract of Ilex kudingcha C.J. Tseng Inhibits Angiogenesis in Zebrafish.","29243968",136]
["Chlorophyll","Chlorophyll","D002734","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"17300741","Action potential in a plant cell lowers the light requirement for non-photochemical energy-dependent quenching of chlorophyll fluorescence.","17300741",136]
["Chlorophyll","Chlorophyll","D002734","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2013,"23894730","Biochemical characterisation of chlorophyllase from leaves of selected Prunus species--a comparative study.","23894730",136]
["chloropicrin","chloropicrin","C100187","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2006,"16536608","Dechlorination of chloropicrin and 1,3-dichloropropene by hydrogen sulfide species: redox and nucleophilic substitution reactions.","16536608",136]
["Chloroquine","Chloroquine","D002738","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1999,"10500178","Phenotypic reversal of the btn1 defects in yeast by chloroquine: a yeast model for Batten disease.","10500178",136]
["chlorosulfonic acid","chlorosulfonic acid","C013880","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"19733344","Physicochemical properties and antitumor activities for sulfated derivatives of lentinan.","19733344",136]
["Chlorpheniramine","Chlorpheniramine","D002744","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2001,"11197163","Separation of cold medicine ingredients by capillary electrophoresis.","11197163",136]
["Chlorpropamide","Chlorpropamide","D002747","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1983,"6347584","Urine pH is important for chlorpropamide elimination.","6347584",136]
["Chlorthalidone","Chlorthalidone","D002752","1_MIE",867,1,"Intracellular pH","Decrease","Acid-Base Equilibrium","D000136","Acid-Base Equilibrium",2,2,1965,"14332159","THE SITE OF ACTION OF FUROSEMIDE AND OTHER SULFONAMIDE DIURETICS IN THE DOG.","14332159",136]
["Cholecalciferol","Cholecalciferol","D002762","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2008,"18628207","Vitamin D3 induces autophagy of human myeloid leukemia cells.","18628207",136]
["cholest-5-en-3 beta,7 alpha-diol","cholest-5-en-3 beta,7 alpha-diol","C011724","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2004,"14994280","Generation of an oxidative stress precedes caspase activation during 7beta-hydroxycholesterol-induced apoptosis in U937 cells.","14994280",136]
["Cholesterol","Cholesterol","D002784","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2006,"16893542","Identification of mobile cholesterol compounds in experimental gliomas by (1)H MRS in vivo: effects of ganciclovir-induced apoptosis on lipids.","16893542",136]
["Cholesterol","Cholesterol","D002784","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,1997,"9090289","Signaling molecules derived from the cholesterol biosynthetic pathway.","9090289",136]
["Cholesterol","Cholesterol","D002784","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27138345","Synthesis, Structural Elucidation, and Biological Evaluation of NSC12, an Orally Available Fibroblast Growth Factor (FGF) Ligand Trap for the Treatment of FGF-Dependent Lung Tumors.","27138345",136]
["Cholesterol","Cholesterol","D002784","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1976,"11682","The binding of the components of mixed micelle to dietary fiber.","11682",136]
["Cholesterol","Cholesterol","D002784","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2011,"21372412","Formulation, characterization and hypersensitivity evaluation of an intravenous emulsion loaded with a paclitaxel-cholesterol complex.","21372412",136]
["Cholesterol","Cholesterol","D002784","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1993,"8263609","Resistant starch decreases serum total cholesterol and triacylglycerol concentrations in rats.","8263609",136]
["Cholesterol","Cholesterol","D002784","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,1,2009,"19292457","Cholesterol exposure at the membrane surface is necessary and sufficient to trigger perfringolysin O binding.","19292457",136]
["cholesteryl myristate","cholesteryl myristate","C032561","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"19723531","Autocrine BMP4 signaling involves effect of cholesterol myristate on proliferation of mesenchymal stem cells.","19723531",136]
["Choline","Choline","D002794","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1964,"14235343","ACETYLCHOLINESTERASE: TRIMETHYLAMMONIUM-ION INHIBITION OF DEACETYLATION.","14235343",136]
["Chondroitin","Chondroitin","D002807","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1954,"13130535","Effect of heat and pH on hyaluronidase.","13130535",136]
["Chondroitin","Chondroitin","D002807","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1969,"5817720","Immune reactions in polysaccharide media. Investigation on complex-formation between some polysaccharides, albumin and immunoglobulin G.","5817720",136]
["chrysophanic acid","chrysophanic acid","C027113","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"27171670","Chrysophanol Induces Apoptosis of Choriocarcinoma Through Regulation of ROS and the AKT and ERK1/2 Pathways.","27171670",136]
["cidofovir","cidofovir","C059262","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25609197","The broad-spectrum anti-DNA virus agent cidofovir inhibits lung metastasis of virus-independent, FGF2-driven tumors.","25609197",136]
["cilostazol","cilostazol","C045645","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1998,"10096838","The quantitative determination of cilostazol and its four metabolites in human liver microsomal incubation mixtures by high-performance liquid chromatography.","10096838",136]
["cimadronate","cimadronate","C071542","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22484715","The bisphosphonate incadronate inhibits intraperitoneal dissemination             in an in vivo pancreatic cancer model.","22484715",136]
["Cimetidine","Cimetidine","D002927","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1995,"7766744","Effect of an evening dose of regular and effervescent formulations of ranitidine or cimetidine on intragastric pH in healthy volunteers.","7766744",136]
["cinnamic aldehyde","cinnamic aldehyde","C012843","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28882558","Cinnamaldehyde protects human dental pulp cells against oxidative stress through the Nrf2/HO-1-dependent antioxidant response.","28882558",136]
["Ciprofloxacin","Ciprofloxacin","D002939","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21871884","Interaction between ciprofloxacin and melanin: the effect on proliferation and melanization in melanocytes.","21871884",136]
["Ciprofloxacin","Ciprofloxacin","D002939","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1989,"2802562","Interaction of the fluoroquinolone antimicrobial agents ciprofloxacin and enoxacin with liposomes.","2802562",136]
["Cisapride","Cisapride","D020117","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2000,"10735928","Gastric myoelectric activity in older adults treated with cisapride for gastro-oesophageal reflux disease.","10735928",136]
["Cisplatin","Cisplatin","D002945","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2001,"11705886","Bimodal effects of 1R,2R-diaminocyclohexane(trans-diacetato)(dichloro)platinum(IV) on cell cycle checkpoints.","11705886",136]
["Cisplatin","Cisplatin","D002945","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2004,"15336528","Action of solamargine on TNFs and cisplatin-resistant human lung cancer cells.","15336528",136]
["Cisplatin","Cisplatin","D002945","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2006,"16376337","NF-kappaB activation is required for cisplatin-induced apoptosis in head and neck squamous carcinoma cells.","16376337",136]
["Cisplatin","Cisplatin","D002945","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2007,"17431112","Luteolin sensitizes the anticancer effect of cisplatin via c-Jun NH2-terminal kinase-mediated p53 phosphorylation and stabilization.","17431112",136]
["Cisplatin","Cisplatin","D002945","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2009,"19414365","Clock gene mouse period2 overexpression inhibits growth of human pancreatic cancer cells and has synergistic effect with cisplatin.","19414365",136]
["Cisplatin","Cisplatin","D002945","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"20727170","Expression of the RNA-binding protein RBM3 is associated with a favourable prognosis and cisplatin sensitivity in epithelial ovarian cancer.","20727170",136]
["Cisplatin","Cisplatin","D002945","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"21494915","Overexpression of p18INK⁴C in LLC-PK1 cells increases resistance to cisplatin-induced apoptosis.","21494915",136]
["Cisplatin","Cisplatin","D002945","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22688731","PDCD5 promotes cisplatin-induced apoptosis of glioma cells via activating mitochondrial apoptotic pathway.","22688731",136]
["Cisplatin","Cisplatin","D002945","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2013,"23933134","Quantitative profiling of tyrosine phosphorylation revealed changes in the activity of the T cell receptor signaling pathway upon cisplatin-induced apoptosis.","23933134",136]
["Cisplatin","Cisplatin","D002945","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24447182","Benzyl isothiocyanate inhibits HNSCC cell migration and invasion, and sensitizes HNSCC cells to cisplatin.","24447182",136]
["Cisplatin","Cisplatin","D002945","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25348020","TXNL1 induces apoptosis in cisplatin resistant human gastric cancer cell lines.","25348020",136]
["Cisplatin","Cisplatin","D002945","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"26462739","Melatonin sensitizes human cervical cancer HeLa cells to cisplatin-induced cytotoxicity and apoptosis: effects on oxidative stress and DNA fragmentation.","26462739",136]
["Cisplatin","Cisplatin","D002945","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2016,"27528390","Enhanced Anti-Tumor Efficacy of Lipid-Modified Platinum Derivatives in Combination with Survivin Silencing siRNA in Resistant Non-Small Cell Lung Cancer.","27528390",136]
["Cisplatin","Cisplatin","D002945","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28012535","Peanut sprout extract attenuates cisplatin-induced ototoxicity by induction of the Akt/Nrf2-mediated redox pathway.","28012535",136]
["Cisplatin","Cisplatin","D002945","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"29247567","ADAM9 is over-expressed in human ovarian clear cell carcinomas and suppresses cisplatin-induced cell death.","29247567",136]
["Cisplatin","Cisplatin","D002945","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2006,"16554155","Novel cisplatin-type platinum complexes and their cytotoxic activity.","16554155",136]
["Cisplatin","Cisplatin","D002945","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20202090","Celecoxib enhances the inhibitory effect of cisplatin on Tca8113 cells in human tongue squamous cell carcinoma in vivo and in vitro.","20202090",136]
["Cisplatin","Cisplatin","D002945","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22967443","[DADLE suppresses the proliferation of human liver cancer HepG2 cells by activation of PKC pathway and elevates the sensitivity to cis-diammine dichloridoplatium].","22967443",136]
["Cisplatin","Cisplatin","D002945","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2014,"24906642","Downregulation of miR-21 increases cisplatin sensitivity of non-small-cell lung cancer.","24906642",136]
["Cisplatin","Cisplatin","D002945","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27240489","Evaluation of the protective effects of hesperetin against cisplatin-induced ototoxicity in a rat animal model.","27240489",136]
["Cisplatin","Cisplatin","D002945","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28641694","[MiR-133b Affect the Proliferation and Drug Sensitivity in A549 Lung Cancer Stem Cells by Targeting PKM2].","28641694",136]
["Cisplatin","Cisplatin","D002945","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2002,"12230397","Factors influencing conformer equilibria in retro models of cisplatin-DNA adducts as revealed by moderately dynamic (N,N'-dimethyl-2,3-diaminobutane)PtG(2) retro models (G = a guanine derivative).","12230397",136]
["Cisplatin","Cisplatin","D002945","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,2,2006,"16489094","Human melanoma cells selected for resistance to apoptosis by prolonged exposure to tumor necrosis factor-related apoptosis-inducing ligand are more vulnerable to necrotic cell death induced by cisplatin.","16489094",136]
["Cisplatin","Cisplatin","D002945","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2013,"23257893","Effect of sorafenib combined with cytostatic agents on hepatoblastoma cell lines and xenografts.","23257893",136]
["Citric Acid","Citric Acid","D019343","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2001,"11716369","Iron promotes cadmium binding to citrate.","11716369",136]
["Citric Acid","Citric Acid","D019343","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2004,"15125570","Citric acid as a pH-regulating additive in granules and the tablet matrix in enteric-coated formulations for colon-specific drug delivery.","15125570",136]
["Citric Acid","Citric Acid","D019343","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2013,"23924538","[Citrate and renal stones].","23924538",136]
["Citrinin","Citrinin","D002953","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2009,"20111678","Inhibition of citrinin-induced apoptotic biochemical signaling in human hepatoma G2 cells by resveratrol.","20111678",136]
["clausine E","clausine E","C522708","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2007,"17548198","Synthesis and antiproliferative activity of clausine E, mukonine, and koenoline bioisosteres.","17548198",136]
["clay","clay","C011730","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1996,"11536747","A review of conditions affecting the radiolysis due to 40K on nucleic acid bases and their derivatives adsorbed on clay minerals: implications in prebiotic chemistry.","11536747",136]
["Clearfil SE Bond","Clearfil SE Bond","C438313","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2002,"12271348","Bond strength of self-etching adhesives to dental hard tissues.","12271348",136]
["clinoptilolite","clinoptilolite","C083175","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2010,"20483536","A comparison of the properties of natural clinoptilolites and their ion-exchange capacities for silver removal.","20483536",136]
["Clioquinol","Clioquinol","D007464","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"19809836","Tumor cellular proteasome inhibition and growth suppression by 8-hydroxyquinoline and clioquinol requires their capabilities to bind copper and transport copper into cells.","19809836",136]
["clofilium","clofilium","C022799","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,1997,"9252253","Screening for novel drug effects with a microphysiometer: a potent effect of clofilium unrelated to potassium channel blockade.","9252253",136]
["Clotrimazole","Clotrimazole","D003022","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"26098874","Nanomicellar Formulation of Clotrimazole Improves Its Antitumor Action toward Human Breast Cancer Cells.","26098874",136]
["Coal","Coal","D003031","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2001,"11285924","Fly ash and lime-stabilized biosolid mixtures in mine spoil reclamation: simulated weathering.","11285924",136]
["Coal","Coal","D003031","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2006,"16841309","Leaching and toxicity behavior of coal-biomass waste cocombustion ashes.","16841309",136]
["cobamamide","cobamamide","C000913","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,1,1996,"8910568","Carboxymethylation of MutS-cysteine-15 specifically inactivates adenosylcobalamin-dependent glutamate mutase. Examination of the role of this residue in coenzyme-binding and catalysis.","8910568",136]
["Cocaine","Cocaine","D003042","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"22451058","Simultaneous analysis of cocaine and its metabolites in urine by capillary electrophoresis-electrospray mass spectrometry using a pressurized liquid junction nanoflow interface.","22451058",136]
["Codeine","Codeine","D003061","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2005,"16309196","Effect of anticancer agents on codeinone-induced apoptosis in human cancer cell lines.","16309196",136]
["coenzyme F420","coenzyme F420","C015084","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"22250969","Zinc-substituted cytochrome P450cam: characterization of protein conformers F420 and F450 by photoinduced electron transfer.","22250969",136]
["Coffee","Coffee","D003069","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2013,"23464918","Statistical optimization of bioprocess parameters for enhanced gallic acid production from coffee pulp tannins by Penicillium verrucosum.","23464918",136]
["Colchicine","Colchicine","D003078","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2011,"22125947","Simultaneous estimation of etoricoxib and thiocolchicoside by RP-HPLC method in combined dosage forms.","22125947",136]
["Colchicine","Colchicine","D003078","7_AO",872,7,"Site of Contact Nasal Tumors","Increase","Nose Neoplasms","D009669","Nose Neoplasms",1,1,1968,"5722582","[The treatment of papillomas of the upper respiratory tract with omain ointment].","5722582",136]
["combretastatin","combretastatin","C040105","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2017,"28527400","Effects of combretastatin A-4 phosphate on canine normal and tumor tissue-derived endothelial cells.","28527400",136]
["Congo Red","Congo Red","D003224","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2017,"29168712","Adsorption of Congo red dye onto antimicrobial terephthaloyl thiourea cross-linked chitosan hydrogels.","29168712",136]
["Copper Sulfate","Copper Sulfate","D019327","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,2,1988,"3192135","Copper-binding protein in acute copper poisoning.","3192135",136]
["costunolide","costunolide","C002602","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27133064","Costunolide, an active sesquiterpene lactone, induced apoptosis via ROS-mediated ER stress and JNK pathway in human U2OS cells.","27133064",136]
["Cottonseed Oil","Cottonseed Oil","D003369","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1978,"31767","Cottonseed protein derivatives as nutritional and functional supplements in food formulations.","31767",136]
["coumarin","coumarin","C030123","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,1998,"9643330","A case of coumarin necrosis with penile and pedal involvement.","9643330",136]
["Creatinine","Creatinine","D003404","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2010,"20939534","Analytical nanosphere sensors using quantum dot-enzyme conjugates for urea and creatinine.","20939534",136]
["Creatinine","Creatinine","D003404","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1970,"5524321","Factors affecting excretion of catecholamines in man: urine flow, urine pH and creatinine clearance.","5524321",136]
["crocin","crocin","C029036","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23909737","Crocus sativus stigma extract and its major constituent crocin possess significant antiproliferative properties against human prostate cancer.","23909737",136]
["cryptolepine","cryptolepine","C024015","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2000,"11099695","Cytotoxicity and cell cycle effects of the plant alkaloids cryptolepine and neocryptolepine: relation to drug-induced apoptosis.","11099695",136]
["cucurbitacin B","cucurbitacin B","C041246","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"20483353","Cucurbitacin B, a small molecule inhibitor of the Stat3 signaling pathway, enhances the chemosensitivity of laryngeal squamous cell carcinoma cells to cisplatin.","20483353",136]
["cucurbitacin B","cucurbitacin B","C041246","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"27881463","Sestrin-3 modulation is essential for therapeutic efficacy of cucurbitacin B in lung cancer cells.","27881463",136]
["Curcumin","Curcumin","D003474","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2004,"15609600","[Experimental study on anticancer effect of curcumin on Raji cells in vitro].","15609600",136]
["Curcumin","Curcumin","D003474","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2007,"17229707","Dysregulation of the ubiquitin-proteasome system by curcumin suppresses coxsackievirus B3 replication.","17229707",136]
["Curcumin","Curcumin","D003474","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"21136025","Bisdemethoxycurcumin protects endothelial cells against t-BHP-induced cell damage by regulating the phosphorylation level of ERK1/2 and Akt.","21136025",136]
["Curcumin","Curcumin","D003474","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"21729550","[Effect of curcumin in combination with bortezomib on proliferation and apoptosis of human multiple myeloma cell line H929 and its mechanism].","21729550",136]
["Curcumin","Curcumin","D003474","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24528086","Curcumin induces caspase mediated apoptosis in JURKAT cells by disrupting the redox balance.","24528086",136]
["Curcumin","Curcumin","D003474","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25644785","Downregulation of PI3-K/Akt/PTEN pathway and activation of mitochondrial intrinsic apoptosis by Diclofenac and Curcumin in colon cancer.","25644785",136]
["Curcumin","Curcumin","D003474","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27127780","Curcumin Downregulates Phosphate Carrier and Protects against Doxorubicin Induced Cardiomyocyte Apoptosis.","27127780",136]
["Curcumin","Curcumin","D003474","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28870814","Curcumin inhibits bladder cancer stem cells by suppressing Sonic Hedgehog pathway.","28870814",136]
["Curcumin","Curcumin","D003474","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2006,"16737669","Down-regulation of prostaglandin E2 by curcumin is correlated with inhibition of cell growth and induction of apoptosis in human colon carcinoma cell lines.","16737669",136]
["Curcumin","Curcumin","D003474","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"21796654","The curcumin analog ca27 down-regulates androgen receptor through an oxidative stress mediated mechanism in human prostate cancer cells.","21796654",136]
["Curcumin","Curcumin","D003474","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24857542","Synthesis, cytotoxicity against human oral cancer KB cells and structure-activity relationship studies of trienone analogues of curcuminoids.","24857542",136]
["Curcumin","Curcumin","D003474","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25692854","Curcumin conjugated with PLGA potentiates sustainability, anti-proliferative activity and apoptosis in human colon carcinoma cells.","25692854",136]
["Curcumin","Curcumin","D003474","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27738325","Antitumor activity of curcumin is involved in down-regulation of YAP/TAZ expression in pancreatic cancer cells.","27738325",136]
["Curcumin","Curcumin","D003474","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2016,"26686156","Hemocompatible curcumin-dextran micelles as pH sensitive pro-drugs for enhanced therapeutic efficacy in cancer cells.","26686156",136]
["curcumol","curcumol","C022801","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2017,"28138126","Curcumol Promotes Vascular Endothelial Growth Factor (VEGF)-Mediated Diabetic Wound Healing in Streptozotocin-Induced Hyperglycemic Rats.","28138126",136]
["CWP232228","CWP232228","C000600091","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25660951","Wnt/β-Catenin Small-Molecule Inhibitor CWP232228 Preferentially Inhibits the Growth of Breast Cancer Stem-like Cells.","25660951",136]
["cyanuric acid","cyanuric acid","C004632","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2016,"26866683","Ovarian Toxicity in Female Rats after Oral Administration of Melamine or Melamine and Cyanuric Acid.","26866683",136]
["Cycloheximide","Cycloheximide","D003513","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,1999,"10704075","A possible involvement of ion transporter in tumor necrosis factor alpha and cycloheximide-induced apoptosis of endothelial cells.","10704075",136]
["Cycloheximide","Cycloheximide","D003513","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2005,"16248531","[Experimental study on induction of the normal human melanocytes apoptosis in vitro by cycloheximide and TNF-alpha].","16248531",136]
["Cyclophosphamide","Cyclophosphamide","D003520","1_MIE",867,1,"Intracellular pH","Decrease","Acid-Base Equilibrium","D000136","Acid-Base Equilibrium",2,3,2005,"15995568","Capacity buffer of the saliva in children and adolescents with cancer: Variations induced by the administration of metotrexate or cyclophosphamide.","15995568",136]
["Cyclophosphamide","Cyclophosphamide","D003520","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27829543","Paeoniflorin ameliorates renal function in cyclophosphamide-induced mice via AMPK suppressed inflammation and apoptosis.","27829543",136]
["Cyclophosphamide","Cyclophosphamide","D003520","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Nasal Mucosa","D009297","Nasal Mucosa",1,1,1992,"1523526","[A case of Wegener's granulomatosis with necrotizing granuloma limited to intraorbital lesions].","1523526",136]
["Cyclophosphamide","Cyclophosphamide","D003520","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2011,"21069336","Improved antiangiogenic and antitumour activity of the combination of the natural flavonoid fisetin and cyclophosphamide in Lewis lung carcinoma-bearing mice.","21069336",136]
["cypermethrin","cypermethrin","C017160","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"21840035","Developmental toxicity of cypermethrin in embryo-larval stages of zebrafish.","21840035",136]
["Cysteamine","Cysteamine","D003543","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1970,"4318006","Electron spin resonance studies of irradiated nucleic acid and nucleic acid-cysteamine systems.","4318006",136]
["cytolethal distending toxin","cytolethal distending toxin","C067044","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2015,"25389664","Cytotoxic mechanism of cytolethal distending toxin in nontyphoidal Salmonella serovar (Salmonella Javiana) during macrophage infection.","25389664",136]
["Cytosine","Cytosine","D003596","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1992,"1579495","The pH dependent configurations of the C.A mispair in DNA.","1579495",136]
["Cytosine","Cytosine","D003596","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,1,1998,"9813119","Sequence and time-dependent deamination of cytosine bases in UVB-induced cyclobutane pyrimidine dimers in vivo.","9813119",136]
["Dacarbazine","Dacarbazine","D003606","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23536437","Temozolomide-mediated DNA methylation in human myeloid precursor cells: differential involvement of intrinsic and extrinsic apoptotic pathways.","23536437",136]
["Dacarbazine","Dacarbazine","D003606","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20072655","Long-term temozolomide treatment induces marked amino metabolism modifications and an increase in TMZ sensitivity in Hs683 oligodendroglioma cells.","20072655",136]
["Dacarbazine","Dacarbazine","D003606","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"22828727","Methoxyamine sensitizes the resistant glioblastoma T98G cell line to the alkylating agent temozolomide.","22828727",136]
["dactolisib","dactolisib","C531198","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2009,"20007781","Specific apoptosis induction by the dual PI3K/mTor inhibitor NVP-BEZ235 in HER2 amplified and PIK3CA mutant breast cancer cells.","20007781",136]
["daidzein","daidzein","C004742","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"17676056","Inhibition of the cellular uptake of anandamide by genistein and its analogue daidzein in cells with different levels of fatty acid amide hydrolase-driven uptake.","17676056",136]
["dan-shen root extract","dan-shen root extract","C028972","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"28459519","Diterpenoid Tanshinones, the extract from Danshen (Radix Salviae","28459519",136]
["Dantrolene","Dantrolene","D003620","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"22118545","Dantrolene is neuroprotective in Huntington's disease transgenic mouse model.","22118545",136]
["Dasatinib","Dasatinib","D000069439","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22419518","Enhancement of natural killer cell effector functions against selected lymphoma and leukemia cell lines by dasatinib.","22419518",136]
["Daunorubicin","Daunorubicin","D003630","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2008,"18193905","Novel nanocomposite of nano fe(3)o(4) and polylactide nanofibers for application in drug uptake and induction of cell death of leukemia cancer cells.","18193905",136]
["Daunorubicin","Daunorubicin","D003630","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"21896327","The role of reactive oxygen species in WP 631-induced death of human ovarian cancer cells: a comparison with the effect of doxorubicin.","21896327",136]
["Daunorubicin","Daunorubicin","D003630","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1996,"8683999","Topoisomerase II activities in AML and their correlation with cellular sensitivity to anthracyclines and epipodophyllotoxines.","8683999",136]
["decamethrin","decamethrin","C017180","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24217896","Deltamethrin induced an apoptogenic signalling pathway in murine thymocytes : exploring the molecular mechanism.","24217896",136]
["deferasirox","deferasirox","C415250","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23278384","Iron chelation: a potential therapeutic strategy in oesophageal cancer.","23278384",136]
["Deferoxamine","Deferoxamine","D003676","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,1997,"9199888","Effect on an iron-chelator on ascorbate-induced cytotoxicity.","9199888",136]
["deguelin","deguelin","C107676","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27745993","Synthesis and biological evaluation of C-ring truncated deguelin derivatives as heat shock protein 90 (HSP90) inhibitors.","27745993",136]
["dehydrocostus lactone","dehydrocostus lactone","C083030","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2009,"19188481","Dehydrocostuslactone, a medicinal plant-derived sesquiterpene lactone, induces apoptosis coupled to endoplasmic reticulum stress in liver cancer cells.","19188481",136]
["demethyleneberberine","demethyleneberberine","C477155","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27376272","Demethyleneberberine Protects against Hepatic Fibrosis in Mice by Modulating NF-κB Signaling.","27376272",136]
["dendron","dendron","C501244","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2015,"26241924","Synthesis, nanoprecipitation and pH sensitivity of amphiphilic linear-dendritic hybrid polymers and hyperbranched-polydendrons containing tertiary amine functional dendrons.","26241924",136]
["Deoxycholic Acid","Deoxycholic Acid","D003840","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2013,"23220290","Lecithin in mixed micelles attenuates the cytotoxicity of bile salts in Caco-2 cells.","23220290",136]
["Deoxyglucose","Deoxyglucose","D003847","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2006,"16855378","Differential mechanisms of radiosensitization by 2-deoxy-D-glucose in the monolayers and multicellular spheroids of a human glioma cell line.","16855378",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C107651,B107651)","v":"Deoxyglucose"},"Deoxyglucose","D003847","1_MIE",867,1,"Intracellular pH","Decrease",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J107651,K107651)","v":"Hydrogen-Ion Concentration"},"D006863","Hydrogen-Ion Concentration",2,2,1994,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q107651,Q107651)","v":"7866516"},"Quantitation of the glycation intermediate 3-deoxyglucosone by oxidation with rabbit liver oxoaldehyde dehydrogenase to 2-keto-3-deoxygluconic acid followed by high-performance liquid chromatography.","7866516",136]
["deoxynivalenol","deoxynivalenol","C007262","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2005,"15588914","Induction of apoptosis and cytokine production in the Jurkat human T cells by deoxynivalenol: role of mitogen-activated protein kinases and comparison to other 8-ketotrichothecenes.","15588914",136]
["Dequalinium","Dequalinium","D003868","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2000,"11104507","Site of action of suramin and reactive blue 2 in preventing neuronal death induced by dequalinium.","11104507",136]
["desloratadine","desloratadine","C121345","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1994,"7952058","Sensitive gas-liquid chromatographic method for the determination of loratadine and its major active metabolite, descarboethoxyloratadine, in human plasma using a nitrogen-phosphorus detector.","7952058",136]
["Dexamethasone","Dexamethasone","D003907","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2002,"12074927","Dexamethasone-induced apoptosis in immune cells from peripheral circulation and lymphomyeloid tissues of juvenile clearnose skates, Raja eglanteria.","12074927",136]
["Dexamethasone","Dexamethasone","D003907","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2003,"12958185","Granzyme A mediates glucocorticoid-induced apoptosis in leukemia cells.","12958185",136]
["Dexamethasone","Dexamethasone","D003907","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2009,"19549914","Increased manganese superoxide dismutase expression or treatment with manganese porphyrin potentiates dexamethasone-induced apoptosis in lymphoma cells.","19549914",136]
["Dexamethasone","Dexamethasone","D003907","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"26700298","Anti-inflammatory effects of dexamethasone and meloxicam on Borrelia burgdorferi-induced inflammation in neuronal cultures of dorsal root ganglia and myelinating cells of the peripheral nervous system.","26700298",136]
["Dexamethasone","Dexamethasone","D003907","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Atrophy","D001284","Atrophy",1,1,2006,"16816546","Application of Photoshop-based image analysis and TUNEL for the distribution and quantification of dexamethasone-induced apoptotic cells in rat thymus.","16816546",136]
["Dexamethasone","Dexamethasone","D003907","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2005,"16000198","NF-kappaB activation but not PI3K/Akt is required for dexamethasone dependent protection against TNF-alpha cytotoxicity in L929 cells.","16000198",136]
["Dexamethasone","Dexamethasone","D003907","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21225543","Morphofunctional alterations in endocrine pancreas of short- and long-term dexamethasone-treated rats.","21225543",136]
["Dexamethasone","Dexamethasone","D003907","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1993,"8346951","The effect of intravenous ranitidine on the intragastric pH of preterm infants receiving dexamethasone.","8346951",136]
["Dexamethasone","Dexamethasone","D003907","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Nasal Mucosa","D009297","Nasal Mucosa",1,2,2015,"26514007","[Effect of dexamethasone on the expression of Tregs in allergic rhinitis mice].","26514007",136]
["Dexrazoxane","Dexrazoxane","D064730","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25521189","The catalytic topoisomerase II inhibitor dexrazoxane induces DNA breaks, ATF3 and the DNA damage response in cancer cells.","25521189",136]
["Dextromethorphan","Dextromethorphan","D003915","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"22608417","Simultaneous determination of chloropheniramine maleate and dextromethorphan hydrobromide in plasma sample by hollow fiber liquid phase microextraction and high performance liquid chromatography with the aid of chemometrics.","22608417",136]
["diallyl disulfide","diallyl disulfide","C028009","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2008,"19035312","Diallyl disulfide (DADS) induces apoptosis in human cervical cancer Ca Ski cells via reactive oxygen species and Ca2+-dependent mitochondria-dependent pathway.","19035312",136]
["diallyl disulfide","diallyl disulfide","C028009","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24291451","Mechanism for the protective effect of diallyl disulfide against cyclophosphamide acute urotoxicity in rats.","24291451",136]
["diallylnitrosamine","diallylnitrosamine","C015125","7_AO",872,7,"Site of Contact Nasal Tumors","Increase","Nose Neoplasms","D009669","Nose Neoplasms",1,3,1985,"3972886","Selective induction of nasal cavity tumors in rats by diallylnitrosamine.","3972886",136]
["Diazepam","Diazepam","D003975","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2005,"16375836","Formulation and evaluation of diazepam hydrogel for rectal administration.","16375836",136]
["Diazoxide","Diazoxide","D003981","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2004,"15292032","Short-term intermittent exposure to diazoxide improves functional performance of beta-cells in a high-glucose environment.","15292032",136]
["Diazoxide","Diazoxide","D003981","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27100489","Diazoxide accelerates wound healing by improving EPC function.","27100489",136]
["Dibutyl Phthalate","Dibutyl Phthalate","D003993","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2005,"16002344","Effects of selected xenoestrogens on liver peroxisomes, vitellogenin levels and spermatogenic cell proliferation in male zebrafish.","16002344",136]
["Dichloroacetic Acid","Dichloroacetic Acid","D003999","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"26935268","In human alloreactive CD4⁺ T-cells, dichloroacetate inhibits aerobic glycolysis, induces apoptosis and favors differentiation towards the regulatory T-cell subset instead of effector T-cell subsets.","26935268",136]
["Dichloroacetic Acid","Dichloroacetic Acid","D003999","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1992,"1356994","Effect of dichloroacetate on recovery of brain lactate, phosphorus energy metabolites, and glutamate during reperfusion after complete cerebral ischemia in rats.","1356994",136]
["Diclofenac","Diclofenac","D004008","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2003,"12826271","Diclofenac inhibits proliferation and differentiation of neural stem cells.","12826271",136]
["Diclofenac","Diclofenac","D004008","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2016,"26498962","Oxidative degradation of diclofenac by thermally activated persulfate: implication for ISCO.","26498962",136]
["dideoxypetrosynol A","dideoxypetrosynol A","C499970","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2007,"17143540","Inhibition of cyclooxygenase-2 and telomerase activities in human leukemia cells by dideoxypetrosynol A, a polyacetylene from the marine sponge Petrosia sp.","17143540",136]
["Dietary Fiber","Dietary Fiber","D004043","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2003,"12715252","Production of laccase and manganese peroxidase by Fomes sclerodermeus grown on wheat bran.","12715252",136]
["Dietary Fiber","Dietary Fiber","D004043","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2009,"18805682","Potential prebiotic activity of oligosaccharides obtained by enzymatic conversion of durum wheat insoluble dietary fibre into soluble dietary fibre.","18805682",136]
["Dietary Fiber","Dietary Fiber","D004043","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1983,"6306185","Effects of avoparcin on ruminal propionate production and amino acid degradation in sheep fed high and low fiber diets.","6306185",136]
["diethyl sulfate","diethyl sulfate","C011612","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,1,2015,"25484124","Enhanced arachidonic acid production from Mortierella alpina combining atmospheric and room temperature plasma (ARTP) and diethyl sulfate treatments.","25484124",136]
["Diethylhexyl Phthalate","Diethylhexyl Phthalate","D004051","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"25450860","Phthalate esters affect maturation and function of primate testis tissue ectopically grafted in mice.","25450860",136]
["Diethylnitrosamine","Diethylnitrosamine","D004052","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25770771","Doxorubicin and curcumin co-delivery by lipid nanoparticles for enhanced treatment of diethylnitrosamine-induced hepatocellular carcinoma in mice.","25770771",136]
["Diethylstilbestrol","Diethylstilbestrol","D004054","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"29277915","Diethylstilbestrol regulates mouse gubernaculum testis cell proliferation via PLC-Ca2+ -CREB pathway.","29277915",136]
["Digitonin","Digitonin","D004072","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1990,"2140057","Regulation of acrosomal matrix dispersion in digitonin-permeabilized guinea pig spermatozoa.","2140057",136]
["Digoxin","Digoxin","D004077","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1982,"7081261","Stability of digoxin in common large-volume injections.","7081261",136]
["dihydroartemisinin","dihydroartemisinin","C039060","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2009,"18466355","Dihydroartemisinin induces apoptosis and sensitizes human ovarian cancer cells to carboplatin therapy.","18466355",136]
["dihydrocapsaicin","dihydrocapsaicin","C012906","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28684048","Dihydrocapsaicin (DHC) enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat.","28684048",136]
["Dihydrostreptomycin Sulfate","Dihydrostreptomycin Sulfate","D004096","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1972,"4114204","Purification and properties of dihydrostreptomycin-phosphorylating enzyme from Pseudomonas aeruginosa.","4114204",136]
["Dihydroxyacetone","Dihydroxyacetone","D004098","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"24664447","Characterization of Thermotoga maritima glycerol dehydrogenase for the enzymatic production of dihydroxyacetone.","24664447",136]
["Diltiazem","Diltiazem","D004110","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1991,"1822208","Automatic determination of diltiazem and desacetyldiltiazem in human plasma using liquid-solid extraction on disposable cartridges coupled to HPLC--Part II: Optimization of liquid-solid extraction.","1822208",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C114627,B114627)","v":"Dimethyl Fumarate"},"Dimethyl Fumarate","D000069462","3_KE",870,3,"Cell Proliferation","Increase",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J114627,K114627)","v":"Cell Proliferation"},"D049109","Cell Proliferation",1,2,2014,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q114627,Q114627)","v":"24731948"},"Neuroprotective dimethyl fumarate synergizes with immunomodulatory interferon beta to provide enhanced axon protection in autoimmune neuroinflammation.","24731948",136]
["Dimethyl Sulfoxide","Dimethyl Sulfoxide","D004121","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,1995,"7843285","Dimethyl sulfoxide suppresses apoptosis in Burkitt's lymphoma cells.","7843285",136]
["Dimethyl Sulfoxide","Dimethyl Sulfoxide","D004121","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"22656241","Effect of hydrogen bonds on pKa values: importance of networking.","22656241",136]
["Dimethylnitrosamine","Dimethylnitrosamine","D004128","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2000,"11334361","Unique organoprotective properties of a novel IH636 grape seed proanthocyanidin extract on cadmium chloride-induced nephrotoxicity, dimethylnitrosamine (DMN)-induced splenotoxicity and mocap-induced neurotoxicity in mice.","11334361",136]
["Dimyristoylphosphatidylcholine","Dimyristoylphosphatidylcholine","D004134","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2005,"15700314","Novel mechanism of hybrid liposomes-induced apoptosis in human tumor cells.","15700314",136]
["dinaciclib","dinaciclib","C553669","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2016,"27486754","Inhibition of cyclin dependent kinase 9 by dinaciclib suppresses cyclin B1 expression and tumor growth in triple negative breast cancer.","27486754",136]
["Dinoprost","Dinoprost","D015237","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1984,"6596427","Physical model approach to gastrointestinal absorption of prostaglandins II: In situ rat intestinal absorption of dinoprost.","6596427",136]
["Dinoprostone","Dinoprostone","D015232","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,1998,"9694511","Prostaglandin E2 inhibits apoptosis in human neutrophilic polymorphonuclear leukocytes: role of intracellular cyclic AMP levels.","9694511",136]
["Dinoprostone","Dinoprostone","D015232","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2010,"20187806","Platelet-activating factor-induced intracellular signaling and release of cytokines and prostaglandin E2 in immortalized human corneal epithelial cells.","20187806",136]
["Dinoprostone","Dinoprostone","D015232","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2010,"20338689","Adult Dirofilaria immitis excretory/secretory antigens upregulate the production of prostaglandin E2 and downregulate monocyte transmigration in an \"in vitro\" model of vascular endothelial cell cultures.","20338689",136]
["dinoseb","dinoseb","C018527","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2003,"12725384","Differential pulse adsorptive stripping voltammetric determination of dinoseb and dinoterb at a modified electrode.","12725384",136]
["Diosgenin","Diosgenin","D004144","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"26091236","In Vivo Protective Effects of Diosgenin against Doxorubicin-Induced Cardiotoxicity.","26091236",136]
["Diosgenin","Diosgenin","D004144","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2016,"27227546","Methyl Protodioscin, a Steroidal Saponin, Inhibits Neointima Formation in Vitro and in Vivo.","27227546",136]
["Diphenhydramine","Diphenhydramine","D004155","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,2,1970,"4394358","Action of antihistamines on the endometrium and the histamine theory of decidual induction.","4394358",136]
["Diphtheria Toxoid","Diphtheria Toxoid","D004168","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1990,"2084450","[Physico-chemical studies of aluminum hydroxide in biological preparations preserved in different conditions].","2084450",136]
["Direct Blue 71","Direct Blue 71","C408744","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2000,"10768767","Direct Blue 71 staining of proteins bound to blotting membranes.","10768767",136]
["Disulfiram","Disulfiram","D004221","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"23165409","High-throughput chemical screens identify disulfiram as an inhibitor of human glioblastoma stem cells.","23165409",136]
["Disulfiram","Disulfiram","D004221","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1997,"9185327","The effects of disulfiram and related compounds on equine hepatic alcohol dehydrogenase.","9185327",136]
["Ditiocarb","Ditiocarb","D004050","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1994,"8006105","Determination of cisplatin and cis-diammineaquachloroplatinum(II) ion by liquid chromatography using post-column derivatization with diethyldithiocarbamate.","8006105",136]
["Dobutamine","Dobutamine","D004280","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"25493021","Inhibitory effects of dobutamine on human gastric adenocarcinoma.","25493021",136]
["docetaxel","docetaxel","C067311","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2009,"19521959","Sphingosine kinase 1 inhibition sensitizes hormone-resistant prostate cancer to docetaxel.","19521959",136]
["docetaxel","docetaxel","C067311","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22586300","GDC-0941, a novel class I selective PI3K inhibitor, enhances the efficacy of docetaxel in human breast cancer models by increasing cell death in vitro and in vivo.","22586300",136]
["docetaxel","docetaxel","C067311","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2017,"28560449","Hypoxia-induced angiopoietin-like protein 4 as a clinical biomarker and treatment target for human prostate cancer.","28560449",136]
["docetaxel","docetaxel","C067311","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"26276154","The Synergistic Effect of Selumetinib/Docetaxel Combination Therapy Monitored by [(18)F]FDG/[(18)F]FLT PET and Diffusion-Weighted Magnetic Resonance Imaging in a Colorectal Tumor Xenograft Model.","26276154",136]
["docetaxel","docetaxel","C067311","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28981599","DKK4-knockdown enhances chemosensitivity of A549/DTX cells to docetaxel.","28981599",136]
["dodecylphosphocholine","dodecylphosphocholine","C028810","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2002,"11806918","Spatial structure of zervamicin IIB bound to DPC micelles: implications for voltage-gating.","11806918",136]
["Dopamine","Dopamine","D004298","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2002,"11792467","Differential effect of catecholamines and MPP(+) on membrane permeability in brain mitochondria and cell viability in PC12 cells.","11792467",136]
["Dopamine","Dopamine","D004298","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2007,"17583437","Unique responses to mitochondrial complex I inhibition in tuberoinfundibular dopamine neurons may impart resistance to toxic insult.","17583437",136]
["Dopamine","Dopamine","D004298","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,1998,"9860264","Glutathione protects PC12 cells from ascorbate- and dopamine-induced apoptosis.","9860264",136]
["Dopamine","Dopamine","D004298","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2005,"16142328","Anti-proliferative activity of haloperidol in B16 mouse and human SK-MEL-28 melanoma cell lines.","16142328",136]
["Dopamine","Dopamine","D004298","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1991,"1716062","Hormone responses of proximal Na(+)-H+ exchanger in spontaneously hypertensive rats.","1716062",136]
["Dopamine","Dopamine","D004298","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1978,"28121","Dopamine-stimulated adenylate cyclase activity in the human brain: changes in Parkinsonism.","28121",136]
["Dopamine","Dopamine","D004298","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1970,"5515480","[Extrapyramidal syndrome in animal experiments: rôle of calcium and o-methylated derivatives].","5515480",136]
["Dopamine","Dopamine","D004298","7_AO",872,7,"Site of Contact Nasal Tumors","Increase","Nose","D009666","Nose",1,1,2017,"28135884","Intranasal administration of dopamine attenuates unconditioned fear in that it reduces restraint-induced ultrasound vocalizations and escape from bright light.","28135884",136]
["Doxepin","Doxepin","D004316","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1999,"10677000","Stereoselective measurement of E- and Z-doxepin and its N-desmethyl and hydroxylated metabolites by gas chromatography-mass spectrometry.","10677000",136]
["Doxorubicin","Doxorubicin","D004317","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2004,"15246544","Roles of cyclin-dependent kinase 4 and p53 in neuronal cell death induced by doxorubicin on cerebellar granule neurons in mouse.","15246544",136]
["Doxorubicin","Doxorubicin","D004317","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2005,"15753397","Regulation of p38 phosphorylation and topoisomerase IIalpha expression in the B-cell lymphoma line Jiyoye by CD26/dipeptidyl peptidase IV is associated with enhanced in vitro and in vivo sensitivity to doxorubicin.","15753397",136]
["Doxorubicin","Doxorubicin","D004317","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2007,"17591362","Effect of melatonin on cytotoxicity of doxorubicin toward selected cell lines (human keratinocytes, lung cancer cell line A-549, laryngeal cancer cell line Hep-2).","17591362",136]
["Doxorubicin","Doxorubicin","D004317","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"20174822","Nutlin-3 cooperates with doxorubicin to induce apoptosis of human hepatocellular carcinoma cells through p53 or p73 signaling pathways.","20174822",136]
["Doxorubicin","Doxorubicin","D004317","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22662203","Nilotinib counteracts P-glycoprotein-mediated multidrug resistance and synergizes the antitumoral effect of doxorubicin in soft tissue sarcomas.","22662203",136]
["Doxorubicin","Doxorubicin","D004317","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2013,"23350792","Increasing the rate of heating: a potential therapeutic approach for achieving synergistic tumour killing in combined hyperthermia and chemotherapy.","23350792",136]
["Doxorubicin","Doxorubicin","D004317","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24689987","AS1411 aptamer and folic acid functionalized pH-responsive ATRP fabricated pPEGMA-PCL-pPEGMA polymeric nanoparticles for targeted drug delivery in cancer therapy.","24689987",136]
["Doxorubicin","Doxorubicin","D004317","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"26373715","Persistent GP130/STAT3 Signaling Contributes to the Resistance of Doxorubicin, Cisplatin, and MEK Inhibitor in Human Rhabdomyosarcoma Cells.","26373715",136]
["Doxorubicin","Doxorubicin","D004317","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28125433","PI3K-δ inhibition using CAL-101 exerts apoptotic effects and increases doxorubicin-induced cell death in pre-B-acute lymphoblastic leukemia cells.","28125433",136]
["Doxorubicin","Doxorubicin","D004317","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28178630","Combination of SL327 and Sunitinib Malate leads to an additive anti-cancer effect in doxorubicin resistant thyroid carcinoma cells.","28178630",136]
["Doxorubicin","Doxorubicin","D004317","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2005,"16025847","Mechanochemically activated doxorubicin nanoparticles in combination with 40 MHz frequency irradiation on A-549 lung carcinoma cells.","16025847",136]
["Doxorubicin","Doxorubicin","D004317","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20965828","[Adriamycin enhances the sonodynamic effect of chlorin e6 against the proliferation of human breast cancer MDA-MB-231 cells in vitro].","20965828",136]
["Doxorubicin","Doxorubicin","D004317","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21873067","Synthesis of pheophorbide-a conjugates with anticancer drugs as potential cancer diagnostic and therapeutic agents.","21873067",136]
["Doxorubicin","Doxorubicin","D004317","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2014,"24934165","Modulation of Doxorubicin mediated growth inhibition of hepatocellular carcinoma cells by platelet lysates.","24934165",136]
["Doxorubicin","Doxorubicin","D004317","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27485415","Nitidine chloride inhibits proliferation, induces apoptosis via the Akt pathway and exhibits a synergistic effect with doxorubicin in ovarian cancer cells.","27485415",136]
["Doxorubicin","Doxorubicin","D004317","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2008,"17999164","A biodegradable pH-sensitive micelle system for targeting acidic solid tumors.","17999164",136]
["Doxorubicin","Doxorubicin","D004317","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2013,"23271041","Polyelectrolyte capsules packaging BSA gels for pH-controlled drug loading and release and their antitumor activity.","23271041",136]
["Doxorubicin","Doxorubicin","D004317","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"24849874","Light and pH dual-degradable triblock copolymer micelles for controlled intracellular drug release.","24849874",136]
["Doxorubicin","Doxorubicin","D004317","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2015,"26604751","Tumor-targeted and pH-controlled delivery of doxorubicin using gold nanorods for lung cancer therapy.","26604751",136]
["Doxorubicin","Doxorubicin","D004317","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2017,"28683183","PEGylated Dendritic Polyglycerol Conjugate Delivers Doxorubicin to the Parasitophorous Vacuole in Leishmania infantum Infections.","28683183",136]
["Doxorubicin","Doxorubicin","D004317","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2008,"18608584","RF ablation with adjuvant therapy: comparison of external beam radiation and liposomal doxorubicin on ablation efficacy in an animal tumor model.","18608584",136]
["Doxorubicin","Doxorubicin","D004317","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,1981,"7336481","Plasma and tissue distribution of adriamycin in patients with pelvic cancer.","7336481",136]
["Doxycycline","Doxycycline","D004318","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"26111245","Doxycycline Induces Apoptosis and Inhibits Proliferation and Invasion of Human Cervical Carcinoma Stem Cells.","26111245",136]
["Drinking Water","Drinking Water","D060766","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2015,"25860623","A comparative study of coagulation, granular- and powdered-activated carbon for the removal of perfluorooctane sulfonate and perfluorooctanoate in drinking water treatment.","25860623",136]
["Dronabinol","Dronabinol","D013759","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24841204","Histone modifications are associated with Δ9-tetrahydrocannabinol-mediated alterations in antigen-specific T cell responses.","24841204",136]
["DTPP","DTPP","C014475","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"24964751","Combination of a novel photosensitizer DTPP with 650 nm laser results in efficient apoptosis, arresting cell cycle and cytoskeleton protein changes in lung cancer A549 cells.","24964751",136]
["Durapatite","Durapatite","D017886","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2007,"16543282","Three-dimensional nanohydroxyapatite/chitosan scaffolds as potential tissue engineered periodontal tissue.","16543282",136]
["Durapatite","Durapatite","D017886","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21985282","Comparison of in vitro biocompatibility of NanoBone(®)  and BioOss(®)  for human osteoblasts.","21985282",136]
["Durapatite","Durapatite","D017886","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23261554","Magnetic nanohydroxyapatite/PVA composite hydrogels for promoted osteoblast adhesion and proliferation.","23261554",136]
["Durapatite","Durapatite","D017886","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"26646551","(9R)-9-Hydroxystearate-Functionalized Hydroxyapatite as Antiproliferative and Cytotoxic Agent toward Osteosarcoma Cells.","26646551",136]
["Durapatite","Durapatite","D017886","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2009,"18650005","Comments on \"factors influencing the removal of divalent cations by hydroxyapatite\".","18650005",136]
["Durapatite","Durapatite","D017886","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"22813837","Effect of iron II on hydroxyapatite dissolution and precipitation in vitro.","22813837",136]
["Durapatite","Durapatite","D017886","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1997,"9104699","Mechanism of the hardening process for a hydroxyapatite cement.","9104699",136]
["Dust","Dust","D004391","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Nasal Mucosa","D009297","Nasal Mucosa",1,1,1987,"3432927","The effect of wood dust on the nasal cavity and paranasal sinuses.","3432927",136]
["Dyphylline","Dyphylline","D004400","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2003,"14522037","Simultaneous determination of theophylline and dyphylline by micellar electrokinetic chromatography and application in drug formulations.","14522037",136]
["EAPB0503","EAPB0503","C555838","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28797090","Imidazoquinoxaline anticancer derivatives and imiquimod interact with tubulin: Characterization of molecular microtubule inhibiting mechanisms in correlation with cytotoxicity.","28797090",136]
["echinacoside","echinacoside","C060297","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24797709","Echinacoside ameliorates D-galactosamine plus lipopolysaccharide-induced acute liver injury in mice via inhibition of apoptosis and inflammation.","24797709",136]
["Edetic Acid","Edetic Acid","D004492","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2001,"11695914","Cleavage of telomeric G-quadruplex DNA with perylene-EDTA*Fe(II).","11695914",136]
["Edetic Acid","Edetic Acid","D004492","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2008,"18160074","Separation of rare earth elements by anion-exchange chromatography using ethylenediaminetetraacetic acid as mobile phase.","18160074",136]
["Edetic Acid","Edetic Acid","D004492","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1985,"3935663","Differentiation among closely related organisms of the Actinobacillus-Haemophilus-Pasteurella group by means of lysozyme and EDTA.","3935663",136]
["efavirenz","efavirenz","C098320","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20649602","Enhanced oxidative stress and increased mitochondrial mass during efavirenz-induced apoptosis in human hepatic cells.","20649602",136]
["Eicosapentaenoic Acid","Eicosapentaenoic Acid","D015118","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2007,"18060632","Modulatory effects of EPA and DHA on proliferation and apoptosis of pancreatic cancer cells.","18060632",136]
["Eicosapentaenoic Acid","Eicosapentaenoic Acid","D015118","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"22213040","Omega-3-polyunsaturated fatty acids suppress pancreatic cancer cell growth in vitro and in vivo via downregulation of Wnt/Beta-catenin signaling.","22213040",136]
["eleostearic acid","eleostearic acid","C004934","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22609276","Beta-eleostearic acid induce apoptosis in T24 human bladder cancer cells through reactive oxygen species (ROS)-mediated pathway.","22609276",136]
["ellipticine","ellipticine","C034192","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"20069337","A novel structural derivative of natural alkaloid ellipticine, MDPSQ, induces necrosis in leukemic cells.","20069337",136]
["Emodin","Emodin","D004642","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2001,"11682458","Protein kinase C involvement in aloe-emodin- and emodin-induced apoptosis in lung carcinoma cell.","11682458",136]
["Emodin","Emodin","D004642","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2008,"17886230","Inhibitory effects of emodin on the proliferation of cultured rat vascular smooth muscle cell-induced by angiotensin II.","17886230",136]
["Emodin","Emodin","D004642","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23744534","Emodin can induce K562 cells to erythroid differentiation and improve the expression of globin genes.","23744534",136]
["Endosulfan","Endosulfan","D004726","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2006,"16730891","Bioremediation of endosulfan contaminated soil and water -- optimization of operating conditions in laboratory scale reactors.","16730891",136]
["Enoximone","Enoximone","D017335","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2003,"12657857","In vitro and in vivo effects of the phosphodiesterase-III inhibitor enoximone on malignant hyperthermia-susceptible swine.","12657857",136]
["enterotoxin B, staphylococcal","enterotoxin B, staphylococcal","C031818","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2008,"19088822","[Cloning deletion of mouse medullary CD4SP thymocyte subgroups induced by superantigen staphylococcal enterotoxin B].","19088822",136]
["enterotoxin B, staphylococcal","enterotoxin B, staphylococcal","C031818","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2012,"22659034","CD44 as a novel target for treatment of staphylococcal enterotoxin B-induced acute inflammatory lung injury.","22659034",136]
["entinostat","entinostat","C118739","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"19181544","Experimental study on inhibitory effects of histone deacetylase inhibitor MS-275 and TSA on bladder cancer cells.","19181544",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C129667,B129667)","v":"Ephedrine"},"Ephedrine","D004809","1_MIE",867,1,"Intracellular pH","Decrease",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J129667,K129667)","v":"Hydrogen-Ion Concentration"},"D006863","Hydrogen-Ion Concentration",2,2,2009,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q129667,Q129667)","v":"19294691"},"The use of CE ECL with ionic liquid for the determination of drug alkaloids and applications in human urine.","19294691",136]
["Ephedrine","Ephedrine","D004809","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1983,"6649793","Conformational study of catecholamines in solution.","6649793",136]
["epigallocatechin gallate","epigallocatechin gallate","C045651","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2003,"14519825","Tea and cancer prevention: studies in animals and humans.","14519825",136]
["epigallocatechin gallate","epigallocatechin gallate","C045651","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22426481","Epigallocatechin-3-gallate inhibits apoptosis and protects testicular seminiferous tubules from ischemia/reperfusion-induced inflammation.","22426481",136]
["epigallocatechin gallate","epigallocatechin gallate","C045651","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"27864105","Epigallocatechin-3-gallate prevents cardiac apoptosis by modulating the intrinsic apoptotic pathway in isoproterenol-induced myocardial infarction.","27864105",136]
["epigallocatechin gallate","epigallocatechin gallate","C045651","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2012,"22056360","Epigallocatechin-3-gallate ameliorates experimental autoimmune encephalomyelitis by altering balance among CD4+ T-cell subsets.","22056360",136]
["epigallocatechin gallate","epigallocatechin gallate","C045651","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23994611","Green tea phenolics inhibit butyrate-induced differentiation of colon cancer cells by interacting with monocarboxylate transporter 1.","23994611",136]
["Epinephrine","Epinephrine","D004837","1_MIE",867,1,"Intracellular pH","Decrease","Acid-Base Equilibrium","D000136","Acid-Base Equilibrium",2,3,2008,"18212696","The effect of milrinone on metabolism after cardiopulmonary bypass.","18212696",136]
["Epinephrine","Epinephrine","D004837","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1990,"1966535","Inhibitory effect of epinephrine on phosphatidate activity in isolated rat hepatocytes.","1966535",136]
["Epinephrine","Epinephrine","D004837","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1989,"2551953","Modulation of the responses of fetal sheep to adrenergic stimulation by adrenal demedullation and chemical sympathectomy.","2551953",136]
["Epinephrine","Epinephrine","D004837","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1980,"7397111","Electrogenic epinephrine transport in chromaffin granule ghosts.","7397111",136]
["Epinephrine","Epinephrine","D004837","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,2,1977,"918349","Protective effect of ethanol against epinephrine-induced myocardial necrosis in rats.","918349",136]
["Epoprostenol","Epoprostenol","D011464","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2007,"17463330","Inducible cAMP early repressor inhibits growth of vascular smooth muscle cell.","17463330",136]
["Epoprostenol","Epoprostenol","D011464","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28851689","The Second-Generation PGI2 Analogue Treprostinil Fails to Chemoprevent Tumors in a Murine Lung Adenocarcinoma Model.","28851689",136]
["epsilon-viniferin","epsilon-viniferin","C091891","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24783205","Bacteriostatic antimicrobial combination: antagonistic interaction between epsilon-viniferin and vancomycin against methicillin-resistant Staphylococcus aureus.","24783205",136]
["Ergosterol","Ergosterol","D004875","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1986,"3951434","Effect of the polar head structure of polyene macrolide antifungal antibiotics on the mode of permeabilization of ergosterol- and cholesterol-containing lipidic vesicles studied by 31P-NMR.","3951434",136]
["Erlotinib Hydrochloride","Erlotinib Hydrochloride","D000069347","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"26796257","TGF-β1 induces erlotinib resistance in non-small cell lung cancer by down-regulating PTEN.","26796257",136]
["Erlotinib Hydrochloride","Erlotinib Hydrochloride","D000069347","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2010,"20564646","Signaling of ERBB receptor tyrosine kinases promotes neuroblastoma growth in vitro and in vivo.","20564646",136]
["Erythritol","Erythritol","D004896","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2002,"12482608","LytB protein catalyzes the terminal step of the 2-C-methyl-D-erythritol-4-phosphate pathway of isoprenoid biosynthesis.","12482608",136]
["Erythromycin","Erythromycin","D004917","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1996,"8782239","Lung clearance of aerosolized 99mTc erythromycin lactobionate in rabbits.","8782239",136]
["erythromycin B 2'-ethyl succinate","erythromycin B 2'-ethyl succinate","C501700","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2006,"17034139","Pediatric erythromycins: a comparison of the properties of erythromycins A and B 2'-ethyl succinates.","17034139",136]
["Esomeprazole","Esomeprazole","D064098","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,3,2007,"18030229","Pharmacokinetics and acid-suppressive effects of esomeprazole in infants 1-24 months old with symptoms of gastroesophageal reflux disease.","18030229",136]
["Ethacrynic Acid","Ethacrynic Acid","D004976","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1974,"4545575","Effects of ethacrynic acid on frog gastric mucosa in chloride solutions.","4545575",136]
["Ethanol","Ethanol","D000431","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2002,"11919181","Dose-dependent activation of antiapoptotic and proapoptotic pathways by ethanol treatment in human vascular endothelial cells: differential involvement of adenosine.","11919181",136]
["Ethanol","Ethanol","D000431","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2009,"19349917","Ethanol-induced developmental neurodegeneration in secretin receptor-deficient mice.","19349917",136]
["Ethanol","Ethanol","D000431","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23714372","Ethanol inhibits retinal and CNS differentiation due to failure of cell cycle exit via an apoptosis-independent pathway.","23714372",136]
["Ethanol","Ethanol","D000431","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2016,"26655499","Connexin 32 dysfunction promotes ethanol-related hepatocarcinogenesis via activation of Dusp1-Erk axis.","26655499",136]
["Ethanol","Ethanol","D000431","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2007,"17854137","Effects of ethanol on hepatic cellular replication and cell cycle progression.","17854137",136]
["Ethanol","Ethanol","D000431","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28260103","Protective effect of arctigenin on ethanol-induced neurotoxicity in PC12 cells.","28260103",136]
["Ethanol","Ethanol","D000431","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2006,"16444288","Red wine alcohol promotes quercetin absorption and directs its metabolism towards isorhamnetin and tamarixetin in rat intestine in vitro.","16444288",136]
["Ethanol","Ethanol","D000431","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2011,"21316850","Metal precipitation in an ethanol-fed, fixed-bed sulphate-reducing bioreactor.","21316850",136]
["Ethanol","Ethanol","D000431","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2015,"25864026","Combining treatments to improve the fermentation of sugarcane bagasse hydrolysates by ethanologenic Escherichia coli LY180.","25864026",136]
["Ethanol","Ethanol","D000431","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1968,"5695322","The effect of ethanol on the gastrointestinal absorption of drugs in the rat.","5695322",136]
["Ethanol","Ethanol","D000431","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1996,"8778205","Inhibition of gap junction intercellular communications of cultured rat hepatocytes by ethanol: role of ethanol metabolism.","8778205",136]
["Ethanol","Ethanol","D000431","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2008,"18593969","Dehydrogenase interference with enzymatic ethanol assays: forgotten but not gone.","18593969",136]
["Ethanol","Ethanol","D000431","7_AO",872,7,"Site of Contact Nasal Tumors","Increase","Nose","D009666","Nose",1,1,1985,"4073664","Moderate alcohol ingestion increases upper airway resistance in normal subjects.","4073664",136]
["Ethiodized Oil","Ethiodized Oil","D004998","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2005,"16091519","Acute and chronic swine rete arteriovenous malformation models: effect of ethiodol and glacial acetic acid on penetration, dispersion, and injection force of N-butyl 2-cyanoacrylate.","16091519",136]
["ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate","ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate","C456800","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"20022690","HA14-1 sensitizes TNF-alpha-induced apoptosis via inhibition of the NF-kappaB signaling pathway: involvement of reactive oxygen species and JNK.","20022690",136]
["ethyl glucoside","ethyl glucoside","C108400","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28715254","Effects of ethyl-α-d-glucoside on human dermal fibroblasts.","28715254",136]
["ethylcholine aziridinium","ethylcholine aziridinium","C044894","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2004,"14962741","Neuronal gelsolin prevents apoptosis by enhancing actin depolymerization.","14962741",136]
["ethylene","ethylene","C036216","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2005,"15475372","Increases in DNA fragmentation and induction of a senescence-specific nuclease are delayed during corolla senescence in ethylene-insensitive (etr1-1) transgenic petunias.","15475372",136]
["Ethylene Glycol","Ethylene Glycol","D019855","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2017,"28083813","Serum Calcium Concentration in Ethylene Glycol Poisoning.","28083813",136]
["ethylisopropylamiloride","ethylisopropylamiloride","C039614","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2011,"21268658","Decoupling of the catalytic and transport activities of complex I from Rhodothermus marinus by sodium/proton antiporter inhibitor.","21268658",136]
["Ethylmaleimide","Ethylmaleimide","D005033","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1976,"8219","Enzymatic properties of native and N-ethylmaleimide-modified cardiac myosin from normal and thyrotoxic rabbits.","8219",136]
["Ethylnitrosourea","Ethylnitrosourea","D005038","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,1,2006,"16889948","ENU-mutagenesis: insight into immune function and pathology.","16889948",136]
["etiracetam","etiracetam","C026098","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2003,"12658687","Microemulsion electrokinetic chromatography applied for separation of levetiracetam from other antiepileptic drugs in polypharmacy.","12658687",136]
["Etoposide","Etoposide","D005047","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2005,"16086873","[Synergetic cytotoxicity of cisplatin and etoposide to leukemia cell line K562 and its mechanism].","16086873",136]
["Etoposide","Etoposide","D005047","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2007,"17565862","[Role of amifostine against the effect of etoposide on non-Hodgkin lymphoma bone marrow derived mesenchymal stem cells: an in vitro experiment].","17565862",136]
["Etoposide","Etoposide","D005047","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"26774631","Inhibition of myeloperoxidase activity have impact on the formation of DNA double-strand breaks induced by etoposide in HL-60 cell line.","26774631",136]
["Etoposide","Etoposide","D005047","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"23248400","Effect of lithium chloride and antineoplastic drugs on survival and cell cycle of androgen-dependent prostate cancer LNCap cells.","23248400",136]
["eucalyptol","eucalyptol","C010087","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23872422","1,8-Cineol inhibits nuclear translocation of NF-κB p65 and NF-κB-dependent transcriptional activity.","23872422",136]
["Eudragit RS","Eudragit RS","C050528","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2011,"20307250","Novel sustained-release fast-disintegrating multi-unit compressed tablets of lornoxicam containing Eudragit RS coated chitosan-alginate beads.","20307250",136]
["Euro-Collins' solution","Euro-Collins' solution","C037096","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1991,"1718065","The effect of low-potassium-dextran versus Euro-Collins solution for preservation of isolated type II pneumocytes.","1718065",136]
["Ezetimibe","Ezetimibe","D000069438","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2016,"27634173","Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis.","27634173",136]
["fangchinoline","fangchinoline","C060802","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28057423","Design, synthesis and biological activities of tetrandrine and fangchinoline derivatives as antitumer agents.","28057423",136]
["farnesiferol C","farnesiferol C","C553326","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"26225673","Anti-proliferative and Apoptotic Effects of Dendrosomal Farnesiferol C on Gastric Cancer Cells.","26225673",136]
["Fast Green FCF","Fast Green FCF","C007704","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2016,"27824368","Examining the inhibitory potency of food additive fast green FCF against amyloid fibrillogenesis under acidic conditions.","27824368",136]
["fenamiphos","fenamiphos","C002698","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1991,"1685431","Partial characterization of soluble esterase from Heterodera glycines and inhibition by aldicarb and phenamiphos.","1685431",136]
["Fenretinide","Fenretinide","D017313","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,1999,"10188729","N-(4-hydroxyphenyl) retinamide is cytotoxic to melanoma cells in vitro through induction of programmed cell death.","10188729",136]
["Fenretinide","Fenretinide","D017313","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2003,"12792755","Induction of apoptosis by fenretinide in tumor cell lines correlates with DLX2, DLX3 and DLX4 gene expression.","12792755",136]
["Fenretinide","Fenretinide","D017313","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2010,"20404323","Sphingosine kinase mediates resistance to the synthetic retinoid N-(4-hydroxyphenyl)retinamide in human ovarian cancer cells.","20404323",136]
["ferric chloride","ferric chloride","C024555","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2000,"11069814","Reversal of meconium inhibition of pulmonary surfactant by ferric chloride, copper chloride, and acetic acid.","11069814",136]
["ferric hydroxide","ferric hydroxide","C021024","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2009,"19481866","Bromate removal from water by granular ferric hydroxide (GFH).","19481866",136]
["ferric nitrilotriacetate","ferric nitrilotriacetate","C020326","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2001,"11159895","Inhibition of the NA(+)/H(+) exchanger reduces rat hepatic stellate cell activity and liver fibrosis: an in vitro and in vivo study.","11159895",136]
["ferric oxide","ferric oxide","C000499","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2006,"16154264","Decolorization of acid black 24 by the FeGAC/H2O2 process.","16154264",136]
["ferric oxide","ferric oxide","C000499","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"24967645","Arsenic removal from aqueous solutions using Fe3O4-HBC composite: effect of calcination on adsorbents performance.","24967645",136]
["ferric oxyhydroxide","ferric oxyhydroxide","C092844","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2011,"21361285","Photoinduced oxidation of arsenite to arsenate on ferrihydrite.","21361285",136]
["ferric sulfate","ferric sulfate","C024823","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2013,"23787315","Simultaneous removal of nitrogen and phosphorus from wastewater by means of FeS-based autotrophic denitrification.","23787315",136]
["Ferrosoferric Oxide","Ferrosoferric Oxide","D052203","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"22489198","Immobilization of peroxidase onto magnetite modified polyaniline.","22489198",136]
["ferrous sulfate","ferrous sulfate","C020748","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2003,"12685738","Decolorization and degradation of H-acid and other dyes using ferrous-hydrogen peroxide system.","12685738",136]
["ferulic acid","ferulic acid","C004999","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2013,"23840666","Characterization of two Streptomyces enzymes that convert ferulic acid to vanillin.","23840666",136]
["ferumoxides","ferumoxides","C065507","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"19788362","Magnetic resonance imaging of chondrocytes labeled with superparamagnetic iron oxide nanoparticles in tissue-engineered cartilage.","19788362",136]
["Filtek Supreme","Filtek Supreme","C474035","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2011,"20499119","Effects of surface conditioning on repair bond strengths of non-aged and aged microhybrid, nanohybrid, and nanofilled composite resins.","20499119",136]
["Fingolimod Hydrochloride","Fingolimod Hydrochloride","D000068876","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,1998,"9723502","Caspase requirement for the apoptotic death of WR19L-induced by FTY720.","9723502",136]
["Fingolimod Hydrochloride","Fingolimod Hydrochloride","D000068876","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27811359","Sphingosine kinase 1 is a potential therapeutic target for nasopharyngeal carcinoma.","27811359",136]
["flavangenol","flavangenol","C504746","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2005,"16141534","Preventive effect of flavangenol on ischemia/reperfusion-induced acute renal failure in rats.","16141534",136]
["flibanserin","flibanserin","C098107","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2010,"20472059","Predicting in vivo absorption behavior of oral modified release dosage forms containing pH-dependent poorly soluble drugs using a novel pH-adjusted biphasic in vitro dissolution test.","20472059",136]
["Flunarizine","Flunarizine","D005444","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2006,"16485034","Flunarizine induces Nrf2-mediated transcriptional activation of heme oxygenase-1 in protection of auditory cells from cisplatin.","16485034",136]
["flunisolide","flunisolide","C007734","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Nasal Mucosa","D009297","Nasal Mucosa",1,2,1983,"6137165","Comparative trial of flunisolide and beclomethasone dipropionate nasal sprays in patients with seasonal allergic rhinitis.","6137165",136]
["Fluorescein","Fluorescein","D019793","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2002,"12506986","Transepithelial transport of fluorescein in Caco-2 cell monolayers and use of such transport in in vitro evaluation of phenolic acid availability.","12506986",136]
["Fluorescein-5-isothiocyanate","Fluorescein-5-isothiocyanate","D016650","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2010,"20925976","Drop coating deposition Raman spectroscopy of fluorescein isothiocyanate labeled protein.","20925976",136]
["Fluorodeoxyglucose F18","Fluorodeoxyglucose F18","D019788","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Atrophy","D001284","Atrophy",1,1,2017,"28584971","F-18 FDG and F-18 Tau PET in posterior cortical atrophy.","28584971",136]
["Fluorodeoxyglucose F18","Fluorodeoxyglucose F18","D019788","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2012,"22477262","18F-FLT PET performs better than 18F-FDG PET in differentiating malignant uterine corpus tumors from benign leiomyoma.","22477262",136]
["fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether","fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether","C078742","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Nasal Mucosa","D009297","Nasal Mucosa",1,1,1995,"8533915","Inhalation toxicity study of a haloalkene degradant of sevoflurane, Compound A (PIFE), in Sprague-Dawley rats.","8533915",136]
["Fluorouracil","Fluorouracil","D005472","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2004,"15571286","Combinations of 5-fluorouracil with UCN-01 or staurosporine.","15571286",136]
["Fluorouracil","Fluorouracil","D005472","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2006,"17016659","Combination of 5-FU and IFNalpha enhances IFN signaling pathway and caspase-8 activity, resulting in marked apoptosis in hepatoma cell lines.","17016659",136]
["Fluorouracil","Fluorouracil","D005472","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23758730","Teng-Long-Bu-Zhong-Tang, a Chinese herbal formula, enhances anticancer effects of 5--Fluorouracil in CT26 colon carcinoma.","23758730",136]
["Fluorouracil","Fluorouracil","D005472","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"26801985","Protective effect of Bu-Zhong-Yi-Qi decoction, the water extract of Chinese traditional herbal medicine, on 5-fluorouracil-induced intestinal mucositis in mice.","26801985",136]
["Fluorouracil","Fluorouracil","D005472","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"19623659","Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model.","19623659",136]
["Fluorouracil","Fluorouracil","D005472","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24604396","Colon cancer cells treated with 5‑fluorouracil exhibit changes in polylactosamine‑type N‑glycans.","24604396",136]
["Fluorouracil","Fluorouracil","D005472","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24726845","13F-1, a novel 5-fluorouracil prodrug containing an Asn-Gly-Arg (NO2) COOCH3 tripeptide, inhibits human colonic carcinoma growth by targeting Aminopeptidase N (APN/CD13).","24726845",136]
["Fluorouracil","Fluorouracil","D005472","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"22362140","Optimization of an aqueous tablet-coating process containing carboxymethylated Cassia fistula gum.","22362140",136]
["Fluoxetine","Fluoxetine","D005473","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2005,"16139271","Fluoxetine (Prozac) interaction with the mitochondrial voltage-dependent anion channel and protection against apoptotic cell death.","16139271",136]
["Fluoxetine","Fluoxetine","D005473","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2007,"17137724","Wheel running and fluoxetine antidepressant treatment have differential effects in the hippocampus and the spinal cord.","17137724",136]
["Flurazepam","Flurazepam","D005479","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2001,"11275439","Determination of partition coefficients of diazepam and flurazepam between phosphatidylcholine bilayer vesicles and water by second derivative spectrophotometric method.","11275439",136]
["fluticasone furoate","fluticasone furoate","C523187","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Nasal Mucosa","D009297","Nasal Mucosa",1,2,2012,"22391079","No mucosal atrophy and reduced inflammatory cells: active-controlled trial with yearlong fluticasone furoate nasal spray.","22391079",136]
["Folic Acid","Folic Acid","D005492","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23069706","PEI-derivatized fullerene drug delivery using folate as a homing device targeting to tumor.","23069706",136]
["Folic Acid","Folic Acid","D005492","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2014,"24211956","Study of the therapeutic effect of 188Re labeled folate targeting albumin nanoparticle coupled with cis-diamminedichloroplatinum cisplatin on human ovarian cancer.","24211956",136]
["Folic Acid","Folic Acid","D005492","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24947231","Quantitative control of active targeting of nanocarriers to tumor cells through optimization of folate ligand density.","24947231",136]
["Folic Acid","Folic Acid","D005492","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1991,"1863291","pH modulation of the kinetics of rabbit jejunal, brush-border folate transport.","1863291",136]
["Folic Acid","Folic Acid","D005492","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1971,"4397704","[Determination, properties and inhibition of thymidilate synthetase in immature myeloid blood and bone marrow cells].","4397704",136]
["Folic Acid","Folic Acid","D005492","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1982,"6804436","Cation-dependent binding of substrate to the folate transport protein of Lactobacillus casei.","6804436",136]
["Formaldehyde","Formaldehyde","D005557","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2006,"16909603","[Reproductive toxicity of formaldehyde to adult male rats and the functional mechanism concerned].","16909603",136]
["Formaldehyde","Formaldehyde","D005557","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1985,"4033642","[Interaction of formaldehyde with nucleic acids and their structural components in the presence of amines. II. Structure of adenine derivatives formed in the reaction with formaldehyde and primary amine].","4033642",136]
["Formaldehyde","Formaldehyde","D005557","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1984,"6712452","Formaldehyde generation from methenamine salts in spinal cord injury.","6712452",136]
["Formaldehyde","Formaldehyde","D005557","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2010,"20205795","Usefulness of molecular biology performed with formaldehyde-fixed paraffin embedded tissue for the diagnosis of combined pulmonary invasive mucormycosis and aspergillosis in an immunocompromised patient.","20205795",136]
["formic acid","formic acid","C030544","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2017,"28250043","Mechanism of formate-nitrite transporters by dielectric shift of substrate acidity.","28250043",136]
["fosbretabulin","fosbretabulin","C058728","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,1998,"9788591","Induction of apoptosis in proliferating human endothelial cells by the tumor-specific antiangiogenesis agent combretastatin A-4.","9788591",136]
["fosbretabulin","fosbretabulin","C058728","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2017,"28910821","Vascular disrupting agent in pancreatic and hepatic tumour allografts: observations of location-dependent efficacy by MRI, microangiography and histomorphology.","28910821",136]
["Framycetin","Framycetin","D005601","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,1,1996,"8605174","In vitro selection analysis of neomycin binding RNAs with a mutagenized pool of variants of the 16S rRNA decoding region.","8605174",136]
["Fructose","Fructose","D005632","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"21430707","Protection of pancreatic INS-1 β-cells from glucose- and fructose-induced cell death by inhibiting mitochondrial permeability transition with cyclosporin A or metformin.","21430707",136]
["Fructose","Fructose","D005632","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1974,"4454388","[Fructose-induced decrease of 2,3-diphosphoglycerate (2,3-DPG) in human erythrocytes: significance of blood pH].","4454388",136]
["fructose-1,6-diphosphate","fructose-1,6-diphosphate","C029063","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2006,"16817596","Metabolic effects of fructose 1,6-bisphosphate in normoxic and hypoxic states of MG63 osteosarcoma cells.","16817596",136]
["fucoidan","fucoidan","C007789","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24818577","Fucoidan inhibits the proliferation of human urinary bladder cancer T24 cells by blocking cell cycle progression and inducing apoptosis.","24818577",136]
["Fucose","Fucose","D005643","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1997,"9061367","Selectin inhibition: synthesis and evaluation of novel sialylated, sulfated and fucosylated oligosaccharides, including the major capping group of GlyCAM-1.","9061367",136]
["fulvic acid","fulvic acid","C005023","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2005,"16235791","113Cd NMR and fluorescence studies of multiple binding mechanisms of Cd(II) by the Suwannee River fulvic acid.","16235791",136]
["fumagillin","fumagillin","C026211","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,1997,"9224570","Methionine aminopeptidase (type 2) is the common target for angiogenesis inhibitors AGM-1470 and ovalicin.","9224570",136]
["fumonisin B1","fumonisin B1","C056933","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2001,"11282612","Regulation of fumonisin B(1) biosynthesis and conidiation in Fusarium verticillioides by a cyclin-like (C-type) gene, FCC1.","11282612",136]
["furan","furan","C039281","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2005,"16190637","Formation of furan from carbohydrates and ascorbic acid following exposure to ionizing radiation and thermal processing.","16190637",136]
["Furosemide","Furosemide","D005665","1_MIE",867,1,"Intracellular pH","Decrease","Acid-Base Equilibrium","D000136","Acid-Base Equilibrium",2,2,1976,"11850","Evidence of a pure \"contraction alkalosis= in awaken rat.","11850",136]
["Furosemide","Furosemide","D005665","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,2,1974,"4424638","Hepatic necrosis caused by furosemide.","4424638",136]
["G(M1) Ganglioside","G(M1) Ganglioside","D005677","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2016,"27438570","Effects of ganglioside G(M1) and erythropoietin on spinal cord lesions in rats: functional and histological evaluations.","27438570",136]
["Gadolinium DTPA","Gadolinium DTPA","D019786","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2001,"11672632","pH-sensitive paramagnetic liposomes as MRI contrast agents: in vitro feasibility studies.","11672632",136]
["Gadolinium DTPA","Gadolinium DTPA","D019786","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2007,"17700278","Assessment of the vascularity of uterine leiomyomas using double-echo dynamic perfusion-weighted MRI with the first-pass pharmacokinetic model: correlation with histopathology.","17700278",136]
["Galactosamine","Galactosamine","D005688","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2006,"17064618","[Role of hepatocellular apoptosis and mechanisms of liver injury in lipopolysaccharide-induced acute liver failure in D-galactosamine-sensitized rats].","17064618",136]
["Galactose","Galactose","D005690","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Atrophy","D001284","Atrophy",1,1,1967,"4305034","[Galactose-induced pancreatic dystrophy and pancreatitis. Histological, histochemical, and electron microscopic studies].","4305034",136]
["Galactose","Galactose","D005690","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"22038246","Bioconversion of D-galactose to D-tagatose: continuous packed bed reaction with an immobilized thermostable L-arabinose isomerase and efficient purification by selective microbial degradation.","22038246",136]
["Galactose","Galactose","D005690","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Olfactory Mucosa","D009831","Olfactory Mucosa",1,1,2005,"16374714","Ultrastructural localization of alpha-galactose-containing glycoconjugates in the rat vomeronasal organ.","16374714",136]
["Gallic Acid","Gallic Acid","D005707","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2009,"19577552","Gallic acid ester derivatives induce apoptosis and cell adhesion inhibition in melanoma cells: The relationship between free radical generation, glutathione depletion and cell death.","19577552",136]
["Gallic Acid","Gallic Acid","D005707","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2015,"25920332","Gallic Acid Production with Mouldy Polyurethane Particles Obtained from Solid State Culture of Aspergillus niger GH1.","25920332",136]
["gambogic acid","gambogic acid","C052659","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23404459","Cytotoxic effect of gambogic acid on SH-SY5Y neuroblastoma cells is mediated by intrinsic caspase-dependent signaling pathway.","23404459",136]
["gamma-sitosterol","gamma-sitosterol","C025473","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2009,"19456133","Beta-sitosterol inhibits cell growth and induces apoptosis in SGC-7901 human stomach cancer cells.","19456133",136]
["gamma-Tocopherol","gamma-Tocopherol","D024504","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22226829","The antioxidant and anti-inflammatory activities of tocopherols are independent of Nrf2 in mice.","22226829",136]
["Ganciclovir","Ganciclovir","D015774","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"22155904","Valganciclovir prophylaxis against cytomegalovirus impairs lymphocyte proliferation and activation in renal transplant recipients.","22155904",136]
["garcinol","garcinol","C054597","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2007,"17382202","Effects of garcinol and its derivatives on intestinal cell growth: Inhibitory effects and autoxidation-dependent growth-stimulatory effects.","17382202",136]
["Gasoline","Gasoline","D005742","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"20307646","Comparison of immunotoxic effects induced by the extracts from methanol and gasoline engine exhausts in vitro.","20307646",136]
["gefitinib","gefitinib","C419708","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2005,"15753373","Multidrug transporter ABCG2 prevents tumor cell death induced by the epidermal growth factor receptor inhibitor Iressa (ZD1839, Gefitinib).","15753373",136]
["gefitinib","gefitinib","C419708","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28713965","Dihydroartemisinin and gefitinib synergistically inhibit NSCLC cell growth and promote apoptosis via the Akt/mTOR/STAT3 pathway.","28713965",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C153219,B153219)","v":"gefitinib"},"gefitinib","C419708","3_KE",870,3,"Cell Proliferation","Increase",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J153219,K153219)","v":"Cell Proliferation"},"D049109","Cell Proliferation",1,2,2014,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q153219,Q153219)","v":"25122774"},"3,6,2',4',5'-Pentahydroxyflavone, an orally bioavailable multiple protein kinase inhibitor, overcomes gefitinib resistance in non-small cell lung cancer.","25122774",136]
["gefitinib","gefitinib","C419708","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27431492","AT-101 enhances gefitinib sensitivity in non-small cell lung cancer with EGFR T790M mutations.","27431492",136]
["Gemfibrozil","Gemfibrozil","D015248","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1997,"9010630","Interaction of human serum albumin with the electrophilic metabolite 1-O-gemfibrozil-beta-D-glucuronide.","9010630",136]
["Genistein","Genistein","D019833","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2003,"12792805","Pleotropic effects of genistein on MCF-7 breast cancer cells.","12792805",136]
["Genistein","Genistein","D019833","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22734418","[Study on mechanism of the anti hypoxia effect of genistein on osteoblasts in vitro].","22734418",136]
["Genistein","Genistein","D019833","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25675448","Genistein induces apoptosis by the inactivation of the IGF-1R/p-Akt signaling pathway in MCF-7 human breast cancer cells.","25675448",136]
["Genistein","Genistein","D019833","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21749310","Genistein inhibited proliferation and induced apoptosis in acute lymphoblastic leukemia, lymphoma and multiple myeloma cells in vitro.","21749310",136]
["Genistein","Genistein","D019833","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,1,2017,"28520936","Impacts of amino acid substitutions in fungal cytochrome P450 monooxygenase (CYP57B3) on the effective production of 3΄-hydroxygenistein.","28520936",136]
["geoditin A","geoditin A","C445692","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"20161972","Geoditin A induces oxidative stress and apoptosis on human colon HT29 cells.","20161972",136]
["geraniol","geraniol","C007836","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"26154255","Geraniol Suppresses Angiogenesis by Downregulating Vascular Endothelial Growth Factor (VEGF)/VEGFR-2 Signaling.","26154255",136]
["GGTI 298","GGTI 298","C102521","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,1997,"9157972","GGTI-298 induces G0-G1 block and apoptosis whereas FTI-277 causes G2-M enrichment in A549 cells.","9157972",136]
["ginkgolide B","ginkgolide B","C045856","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"22505596","Ginkgo May Sensitize Ovarian Cancer Cells to Cisplatin: Antiproliferative and Apoptosis-Inducing Effects of Ginkgolide B on Ovarian Cancer Cells.","22505596",136]
["ginsenoside M1","ginsenoside M1","C112772","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23907464","A ginseng metabolite, compound K, induces autophagy and apoptosis via generation of reactive oxygen species and activation of JNK in human colon cancer cells.","23907464",136]
["ginsenoside Rg1","ginsenoside Rg1","C035054","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,2,2004,"15337705","Modulating angiogenesis: the yin and the yang in ginseng.","15337705",136]
["ginsenoside Rh2","ginsenoside Rh2","C055305","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2004,"15052284","Ginsenosides 20(S)-protopanaxadiol and Rh2 reduce cell proliferation and increase sub-G1 cells in two cultured intestinal cell lines, Int-407 and Caco-2.","15052284",136]
["Glc(3)Man(9)(GlcNAc)(2)-diphosphate-dolichol","Glc(3)Man(9)(GlcNAc)(2)-diphosphate-dolichol","C066723","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2006,"16691504","Potentiation of angiogenic switch in capillary endothelial cells by cAMP: A cross-talk between up-regulated LLO biosynthesis and the HSP-70 expression.","16691504",136]
["Glucaric Acid","Glucaric Acid","D005937","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,1997,"9278874","Avidity of technetium 99m glucarate for the necrotic myocardium: in vivo and in vitro assessment.","9278874",136]
["gluconic acid","gluconic acid","C030691","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2011,"21389606","Selective, high conversion of D-glucose to 5-keto-D-gluoconate by Gluconobacter suboxydans.","21389606",136]
["Glucosamine","Glucosamine","D005944","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1983,"6631692","Pharmacokinetics of intravenous and oral 1,2-O-isopropylidene-3-O-3'-(N',N'-dimethylamino-n-propyl)-D-glucofuranose hydrochloride in the dog as a function of dose and characterization of metabolites.","6631692",136]
["Glucose","Glucose","D005947","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2001,"11318955","Long-term exposure to high glucose up-regulates VCAM-induced endothelial cell adhesiveness to PBMC.","11318955",136]
["Glucose","Glucose","D005947","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2002,"12217896","Glucose promotes pancreatic islet beta-cell survival through a PI 3-kinase/Akt-signaling pathway.","12217896",136]
["Glucose","Glucose","D005947","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2007,"17466987","In vitro evidence of glucose-induced toxicity in GnRH secreting neurons: high glucose concentrations influence GnRH secretion, impair cell viability, and induce apoptosis in the GT1-1 neuronal cell line.","17466987",136]
["Glucose","Glucose","D005947","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2011,"21570709","Glucose deprivation activates AMPK and induces cell death through modulation of Akt in ovarian cancer cells.","21570709",136]
["Glucose","Glucose","D005947","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2013,"24337844","MicroRNA-34a regulates high glucose-induced apoptosis in H9c2 cardiomyocytes.","24337844",136]
["Glucose","Glucose","D005947","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24859911","Oscillating high glucose enhances oxidative stress and apoptosis in human coronary artery endothelial cells.","24859911",136]
["Glucose","Glucose","D005947","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2016,"26894973","AMPK and PKA interaction in the regulation of survival of liver cancer cells subjected to glucose starvation.","26894973",136]
["Glucose","Glucose","D005947","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,1998,"9488165","Medium transitory oxygen-glucose deprivation induced both apoptosis and necrosis in cerebellar granule cells.","9488165",136]
["Glucose","Glucose","D005947","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2007,"17849168","Effects of elevated glucose levels on interactions of cardiac fibroblasts with the extracellular matrix.","17849168",136]
["Glucose","Glucose","D005947","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20505014","Glucose inhibits angiogenesis of isolated human pancreatic islets.","20505014",136]
["Glucose","Glucose","D005947","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2012,"22476290","Developmental, cytological and transcriptional analysis of autotetraploid Arabidopsis.","22476290",136]
["Glucose","Glucose","D005947","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25499137","Nymphayol increases glucose-stimulated insulin secretion by RIN-5F cells and GLUT4-mediated insulin sensitization in type 2 diabetic rat liver.","25499137",136]
["Glucose","Glucose","D005947","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27982118","Brusatol inhibits HIF-1 signaling pathway and suppresses glucose uptake under hypoxic conditions in HCT116 cells.","27982118",136]
["Glucose","Glucose","D005947","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28800677","Levothyroxine enhances glucose clearance and blunts the onset of experimental type 1 diabetes mellitus in mice.","28800677",136]
["Glucose","Glucose","D005947","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1976,"13622","Pathophysiological aspects of glucose uptake by the tumor tissue under various conditions of oxygen and glucose supply.","13622",136]
["Glucose","Glucose","D005947","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2005,"15657706","Glucose biosensor based on glucose oxidase immobilized in sol-gel chitosan/silica hybrid composite film on Prussian blue modified glass carbon electrode.","15657706",136]
["Glucose","Glucose","D005947","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2008,"18702670","Protonophore- and pH-insensitive glucose and sucrose accumulation detected by FRET nanosensors in Arabidopsis root tips.","18702670",136]
["Glucose","Glucose","D005947","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2010,"20687584","Pulse-voltammetric glucose detection at gold junction electrodes.","20687584",136]
["Glucose","Glucose","D005947","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1975,"237539","Binding of D-glucose to insulin.","237539",136]
["Glucose","Glucose","D005947","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2017,"28238260","Strecker Aldehyde Formation in Wine: New Insights into the Role of Gallic Acid, Glucose, and Metals in Phenylacetaldehyde Formation.","28238260",136]
["Glucose","Glucose","D005947","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1986,"3097229","Blood-pleural fluid glucose and pleural fluid pH, pCO2 relationship. A report of 80 cases of heterogeneous population with the study after intravenous glucose.","3097229",136]
["Glucose","Glucose","D005947","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1970,"4392678","[Significance and regulation of the pentosephosphate pathway in human erythrocytes. I. Experiments with normal erythrocytes].","4392678",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C160195,B160195)","v":"Glucose"},"Glucose","D005947","1_MIE",867,1,"Intracellular pH","Decrease",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J160195,K160195)","v":"Hydrogen-Ion Concentration"},"D006863","Hydrogen-Ion Concentration",2,2,1969,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q160195,Q160195)","v":"5765588"},"Action of concentrated solutions of nonelectrolytes on the dog gastric mucosa.","5765588",136]
["Glucose","Glucose","D005947","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1980,"7406622","Rheumatoid pleurisy. observations on the development of low pleural fluid pH and glucose level.","7406622",136]
["Glucose","Glucose","D005947","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1993,"8250873","Effect of glucose and deoxyglucose on cytoplasmic [Ca2+] in Ehrlich ascites tumor cells.","8250873",136]
["Glucose","Glucose","D005947","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Nasal Mucosa","D009297","Nasal Mucosa",1,2,2015,"25820586","Corticosteroid use does not alter nasal mucus glucose in chronic rhinosinusitis.","25820586",136]
["Glucose Solution, Hypertonic","Glucose Solution, Hypertonic","D005950","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1982,"6808110","Effect of glucose infusion on the maternal and fetal acid-base equilibrium during labor.","6808110",136]
["Glucose-6-Phosphate","Glucose-6-Phosphate","D019298","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,1,2010,"20876143","Structural basis for glucose-6-phosphate activation of glycogen synthase.","20876143",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C161155,B161155)","v":"Glutaral"},"Glutaral","D005976","1_MIE",867,1,"Intracellular pH","Decrease",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J161155,K161155)","v":"Hydrogen-Ion Concentration"},"D006863","Hydrogen-Ion Concentration",2,2,2014,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q161155,Q161155)","v":"24559711"},"Adsorption study of an organo-arsenical with chitosan-based sorbents.","24559711",136]
["glyceollin","glyceollin","C017343","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2015,"25771071","Glyceollin, a novel regulator of mTOR/p70S6 in estrogen receptor positive breast cancer.","25771071",136]
["Glycerol","Glycerol","D005990","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"17785419","Enzymatic synthesis of DNA on glycerol nucleic acid templates without stable duplex formation between product and template.","17785419",136]
["Glycerol","Glycerol","D005990","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2013,"23736068","Toxicity following laundry detergent pod ingestion.","23736068",136]
["Glycerol","Glycerol","D005990","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1996,"8679674","Influence of glycerol on the structure and stability of ferric horse heart myoglobin: a SAXS and circular dichroism study.","8679674",136]
["Glycogen","Glycogen","D006003","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2007,"17965648","Glycogen: a Trojan horse for neurons.","17965648",136]
["Glycogen","Glycogen","D006003","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2017,"28599643","Regulation of the reserve carbohydrate metabolism by alkaline pH and calcium in Neurospora crassa reveals a possible cross-regulation of both signaling pathways.","28599643",136]
["glycolaldehyde","glycolaldehyde","C010972","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2017,"29034432","YKL071W from Saccharomyces cerevisiae encodes a novel aldehyde reductase for detoxification of glycolaldehyde and furfural derived from lignocellulose.","29034432",136]
["Glycyrrhetinic Acid","Glycyrrhetinic Acid","D006034","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2007,"18173125","[Effect of nitrogen-containing derivatives of the plant triterpenes betulin and glycyrrhetic acid on the growth of MT-4, MOLT-4, CEM, and Hep G2 tumor cells].","18173125",136]
["Glyoxal","Glyoxal","D006037","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1975,"1246","The reaction of horse-liver alcohol dehydrogenase with glyoxal.","1246",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C162947,B162947)","v":"goethite"},"goethite","C094886","1_MIE",867,1,"Intracellular pH","Decrease",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J162947,K162947)","v":"Hydrogen-Ion Concentration"},"D006863","Hydrogen-Ion Concentration",2,2,2015,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q162947,Q162947)","v":"25760642"},"Copper and nickel partitioning with nanoscale goethite under variable aquatic conditions.","25760642",136]
["Gossypol","Gossypol","D006072","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2009,"19528479","(-)-Gossypol reduces invasiveness in metastatic prostate cancer cells.","19528479",136]
["Gossypol","Gossypol","D006072","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2014,"24703900","Glucocorticoid sensitisation in Mixed Lineage Leukaemia-rearranged acute lymphoblastic leukaemia by the pan-BCL-2 family inhibitors gossypol and AT-101.","24703900",136]
["granulatimide","granulatimide","C433587","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22809559","Synthesis and biological evaluation of analogs of the marine alkaloids granulatimide and isogranulatimide.","22809559",136]
["Grape Seed Proanthocyanidins","Grape Seed Proanthocyanidins","C511402","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28693689","Neuroprotective Effects of Grape Seed Procyanidin Extract on Ischemia-Reperfusion Brain Injury.","28693689",136]
["grifolan","grifolan","C048444","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1993,"8268846","Application of limulus test (G pathway) for the detection of different conformers of (1--&gt;3)-beta-D-glucans.","8268846",136]
["Guaiacol","Guaiacol","D006139","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20175081","6-Dehydrogingerdione, an active constituent of dietary ginger, induces cell cycle arrest and apoptosis through reactive oxygen species/c-Jun N-terminal kinase pathways in human breast cancer cells.","20175081",136]
["Guanine","Guanine","D006147","3_KE",870,3,"Cell Proliferation","Increase","Airway Remodeling","D056151","Airway Remodeling",2,2,2015,"26187872","Whole transcriptome analysis reveals a role for OGG1-initiated DNA repair signaling in airway remodeling.","26187872",136]
["Guanine","Guanine","D006147","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2005,"15708794","Determination of the stability constants and oxidation susceptibility of nickel(II) complexes with 2'-deoxyguanosine 5'-triphosphate and L-histidine.","15708794",136]
["Guanine","Guanine","D006147","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2008,"18054790","A deoxyribozyme with a novel guanine quartet-helix pseudoknot structure.","18054790",136]
["Guanine","Guanine","D006147","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,1,1993,"8093500","Deficient repair of DNA lesion O6-methylguanine in cirrhosis.","8093500",136]
["GUT-70","GUT-70","C493688","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21139584","Antiproliferative and proapoptotic activity of GUT-70 mediated through potent inhibition of Hsp90 in mantle cell lymphoma.","21139584",136]
["halofuginone","halofuginone","C010176","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2006,"16735800","Inhibition of rat renal fibroblast proliferation by halofuginone.","16735800",136]
["Haloperidol","Haloperidol","D006220","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28756230","Haloperidol, a sigma receptor 1 antagonist, promotes ferroptosis in hepatocellular carcinoma cells.","28756230",136]
["Halothane","Halothane","D006221","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1973,"4753696","Proceedings: The effect of halothane on myocardial blood flow and oxygen consumption.","4753696",136]
["Halothane","Halothane","D006221","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,1972,"4130893","[Morphology and etiology of halothane-induced liver lesions (author's transl)].","4130893",136]
["Halothane","Halothane","D006221","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,1966,"5953371","Summary of the national Halothane Study. Possible association between halothane anesthesia and postoperative hepatic necrosis.","5953371",136]
["HD 03 polyherbal","HD 03 polyherbal","C119007","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2000,"10919100","Effect of HD-03--a herbal formulation in galactosamine-induced hepatopathy in rats.","10919100",136]
["Hematoxylin","Hematoxylin","D006416","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1987,"3036004","Negative and positive assays of superoxide dismutase based on hematoxylin autoxidation.","3036004",136]
["Heme","Heme","D006418","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2006,"16950397","Cofacial heme binding is linked to dimerization by a bacterial heme transport protein.","16950397",136]
["Heme","Heme","D006418","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1986,"3790164","Association of hydrophobic substances with hemin. Characterization of the reverse type I binding spectrum and its relationship to cytochrome P-450.","3790164",136]
["Heme","Heme","D006418","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1973,"4710757","Heme formation from Fe(II) and porphyrin in the absence of ferrochelatase activity.","4710757",136]
["Heme","Heme","D006418","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,1,1995,"7588711","Resolution of the nirD locus for heme d1 synthesis of cytochrome cd1 (respiratory nitrite reductase) from Pseudomonas stutzeri.","7588711",136]
["Hemin","Hemin","D006427","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2015,"25826783","Nisin production of Lactococcus lactis N8 with hemin-stimulated cell respiration in fed-batch fermentation system.","25826783",136]
["Hemin","Hemin","D006427","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2017,"28512172","In Vivo Hemin Conditioning Targets the Vascular and Immunologic Compartments and Restrains Prostate Tumor Development.","28512172",136]
["Heparin","Heparin","D006493","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2008,"18661329","The activities of heparan sulfate and its analogue heparin are dictated by biosynthesis, sequence, and conformation.","18661329",136]
["Heparin","Heparin","D006493","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1992,"1575834","Comparison of the effects of dry and liquid heparin on neonatal arterial blood gases.","1575834",136]
["Heparin","Heparin","D006493","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1986,"3699029","S protein modulates the heparin-catalyzed inhibition of thrombin by antithrombin III. Evidence for a direct interaction of S protein with heparin.","3699029",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C167619,B167619)","v":"Heparin"},"Heparin","D006493","1_MIE",867,1,"Intracellular pH","Decrease",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J167619,K167619)","v":"Hydrogen-Ion Concentration"},"D006863","Hydrogen-Ion Concentration",2,2,1971,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q167619,Q167619)","v":"5002680"},"Cation permeability induced by spermine and Polybrene in rat liver mitochondria.","5002680",136]
["Heparin","Heparin","D006493","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,1983,"6679287","[Therapy of patients with severe liver insufficiency using antithrombin III and plasma derivatives].","6679287",136]
["Heparin","Heparin","D006493","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,1989,"2476646","Metabolism of tumor regression from angiogenesis inhibition: 31P magnetic resonance spectroscopy.","2476646",136]
["Heparitin Sulfate","Heparitin Sulfate","D006497","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2013,"24035513","Renal heparan sulfate proteoglycans modulate fibroblast growth factor 2 signaling in experimental chronic transplant dysfunction.","24035513",136]
["Heparitin Sulfate","Heparitin Sulfate","D006497","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1997,"8999930","Heparanases produce distinct populations of heparan sulfate glycosaminoglycans in Chinese hamster ovary cells.","8999930",136]
["hernandezine","hernandezine","C067193","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"26811496","Hernandezine, a novel AMPK activator induces autophagic cell death in drug-resistant cancers.","26811496",136]
["Hesperidin","Hesperidin","D006569","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2015,"25402552","Topical hesperidin enhances epidermal function in an aged murine model.","25402552",136]
["Hexadimethrine Bromide","Hexadimethrine Bromide","D006583","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,1964,"14203928","EXPERIMENTAL HEXADIMETHRINE NECROSIS OF ZONA GLOMERULOSA AND INNER LAYERS OF ADRENAL CORTEX.","14203928",136]
["HhAntag691","HhAntag691","C538724","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23894677","Vismodegib suppresses TRAIL-mediated liver injury in a mouse model of nonalcoholic steatohepatitis.","23894677",136]
["hispolon","hispolon","C103442","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28618133","Effects of hispolon on glioblastoma cell growth.","28618133",136]
["Histamine","Histamine","D006632","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2000,"10752151","[Study of histamine binding with H2 membrane receptors in the gastric mucosa in Rana ridibunda].","10752151",136]
["Histamine","Histamine","D006632","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1974,"4818381","Responses of human umbilical artery to oxygen, bradykinin and histamine.","4818381",136]
["Histamine","Histamine","D006632","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1969,"5799383","Choleretic effects of secretin and histamine in the dog.","5799383",136]
["Histamine","Histamine","D006632","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Nasal Mucosa","D009297","Nasal Mucosa",1,2,2017,"27913982","Pharmacological Management of Allergic Rhinitis in the Elderly.","27913982",136]
["HMR 1098","HMR 1098","C410297","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2003,"15107598","Selective block of sarcolemmal IKATP in human cardiomyocytes using HMR 1098.","15107598",136]
["honokiol","honokiol","C005499","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2004,"15259066","Honokiol induces apoptosis through p53-independent pathway in human colorectal cell line RKO.","15259066",136]
["honokiol","honokiol","C005499","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"25543478","[Effect of honokiol on proliferation and apoptosis in HL-60 cells and its potential mechanism].","25543478",136]
["HU 211","HU 211","C062018","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2002,"12428278","Activation of cannabinoid receptors decreases the area of ischemic myocardial necrosis.","12428278",136]
["Hyaluronic Acid","Hyaluronic Acid","D006820","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22038822","Hyaluronic acid is radioprotective in the intestine through a TLR4 and COX-2-mediated mechanism.","22038822",136]
["Hyaluronic Acid","Hyaluronic Acid","D006820","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2018,"29588583","siRNA-loaded selenium nanoparticle modified with hyaluronic acid for enhanced hepatocellular carcinoma therapy.","29588583",136]
["Hyaluronic Acid","Hyaluronic Acid","D006820","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"19428469","Preparation and characterization of fibroin/hyaluronic acid composite scaffold.","19428469",136]
["Hyaluronic Acid","Hyaluronic Acid","D006820","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"25115788","The effect of hyaluronic acid functionalized carbon nanotubes loaded with salinomycin on gastric cancer stem cells.","25115788",136]
["Hyaluronic Acid","Hyaluronic Acid","D006820","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"28029125","Ameliorative Effect of Curcumin-Encapsulated Hyaluronic Acid-PLA Nanoparticles on Thioacetamide-Induced Murine Hepatic Fibrosis.","28029125",136]
["Hyaluronic Acid","Hyaluronic Acid","D006820","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1978,"23398","The two dimensional structure of tetrazolium-mucopolysaccharide complexes deduced from reactivity studies.","23398",136]
["Hyaluronic Acid","Hyaluronic Acid","D006820","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2015,"23870043","Facial skin breakdown in patients with non-invasive ventilation devices: report of two cases and indications for treatment and prevention.","23870043",136]
["Hydralazine","Hydralazine","D006830","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,1990,"2327183","[Dihydralazine hepatitis. Morphologic and clinical criteria for diagnosis].","2327183",136]
["Hydrochloric Acid","Hydrochloric Acid","D006851","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2016,"26610296","Comparative studies on the effects of seawater acidification caused by CO₂ and HCl enrichment on physiological changes in Mytilus edulis.","26610296",136]
["Hydrochloric Acid","Hydrochloric Acid","D006851","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2009,"19490646","Afferent signalling from the acid-challenged rat stomach is inhibited and gastric acid elimination is enhanced by lafutidine.","19490646",136]
["Hydrochloric Acid","Hydrochloric Acid","D006851","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1983,"6869549","Intraduodenal emulsions of oleic acid augment acid-induced canine pancreatic secretion.","6869549",136]
["Hydrofluoric Acid","Hydrofluoric Acid","D006858","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,1986,"3698742","[Therapy of hydrofluoric acid burns].","3698742",136]
["Hydrogel, Polyethylene Glycol Dimethacrylate","Hydrogel, Polyethylene Glycol Dimethacrylate","D020136","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2015,"25756853","RoY peptide-modified chitosan-based hydrogel to improve angiogenesis and cardiac repair under hypoxia.","25756853",136]
["Hydrogel, Polyethylene Glycol Dimethacrylate","Hydrogel, Polyethylene Glycol Dimethacrylate","D020136","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27612827","Thixotropic injectable hydrogel using a polyampholyte and nanosilicate prepared directly after cryopreservation.","27612827",136]
["Hydrogel, Polyethylene Glycol Dimethacrylate","Hydrogel, Polyethylene Glycol Dimethacrylate","D020136","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2016,"27140748","Encapsulation of anti-carbonic anhydrase IX antibody in hydrogel microspheres for tumor targeting.","27140748",136]
["Hydrogen Peroxide","Hydrogen Peroxide","D006861","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2000,"10772341","Specific processing of poly(ADP-ribose) polymerase, accompanied by activation of caspase-3 and elevation/reduction of ceramide/hydrogen peroxide levels, during induction of apoptosis in host HL-60 cells infected by the human granulocytic ehrlichiosis (HGE) agent.","10772341",136]
["Hydrogen Peroxide","Hydrogen Peroxide","D006861","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2002,"11960609","Protection by ascorbic acid from denaturation and release of cytochrome c, alteration of mitochondrial membrane potential and activation of multiple caspases induced by H(2)O(2), in human leukemia cells.","11960609",136]
["Hydrogen Peroxide","Hydrogen Peroxide","D006861","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2006,"16341693","EGFR-dependent ERK activation triggers hydrogen peroxide-induced apoptosis in OK renal epithelial cells.","16341693",136]
["Hydrogen Peroxide","Hydrogen Peroxide","D006861","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2009,"19149926","[Protective effects of catechin on apoptosis of endothelial progenitor cells induced by H2O2 in rats].","19149926",136]
["Hydrogen Peroxide","Hydrogen Peroxide","D006861","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23403085","Neuroprotective effects of mercaptoethylleonurine and mercaptoethylguanidine analogs on hydrogen peroxide-induced apoptosis in human neuronal SH-SY5Y cells.","23403085",136]
["Hydrogen Peroxide","Hydrogen Peroxide","D006861","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25757910","MicroRNA-26a overexpression protects RGC-5 cells against H2O2-induced apoptosis.","25757910",136]
["Hydrogen Peroxide","Hydrogen Peroxide","D006861","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"26655928","Akbu-LAAO exhibits potent anti-tumor activity to HepG2 cells partially through produced H2O2 via TGF-β signal pathway.","26655928",136]
["Hydrogen Peroxide","Hydrogen Peroxide","D006861","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2006,"17045923","Involvement of Na+/K+-ATPase in hydrogen peroxide-induced hypertrophy in cardiac myocytes.","17045923",136]
["Hydrogen Peroxide","Hydrogen Peroxide","D006861","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25579808","In vitro human cell responses to a low-dose photodynamic treatment vs. mild H2O2 exposure.","25579808",136]
["Hydrogen Peroxide","Hydrogen Peroxide","D006861","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"27966452","Toxicity assessment of hydrogen peroxide on Toll-like receptor system, apoptosis, and mitochondrial respiration in piglets and IPEC-J2 cells.","27966452",136]
["Hydrogen Peroxide","Hydrogen Peroxide","D006861","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2003,"14714518","[Heat-induced activation of reducing properties of of sea water].","14714518",136]
["Hydrogen Peroxide","Hydrogen Peroxide","D006861","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"17924880","Effects of pH-neutral, super-oxidised solution on human dermal fibroblasts in vitro.","17924880",136]
["Hydrogen Peroxide","Hydrogen Peroxide","D006861","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2010,"20060566","Dramatic enhancement of solar disinfection (SODIS) of wild Salmonella sp. in PET bottles by H2O2 addition on natural water of Burkina Faso containing dissolved iron.","20060566",136]
["Hydrogen Peroxide","Hydrogen Peroxide","D006861","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2010,"20371151","Degradation efficiencies of azo dye Acid Orange 7 by the interaction of heat, UV and anions with common oxidants: persulfate, peroxymonosulfate and hydrogen peroxide.","20371151",136]
["Hydrogen Peroxide","Hydrogen Peroxide","D006861","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2013,"23399534","Arabidopsis heat shock factor HsfA1a directly senses heat stress, pH changes, and hydrogen peroxide via the engagement of redox state.","23399534",136]
["Hydrogen Peroxide","Hydrogen Peroxide","D006861","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2015,"26039560","Modular advanced oxidation process enabled by cathodic hydrogen peroxide production.","26039560",136]
["Hydrogen Peroxide","Hydrogen Peroxide","D006861","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1995,"7492735","Reaction between peroxynitrite and hydrogen peroxide: formation of oxygen and slowing of peroxynitrite decomposition.","7492735",136]
["Hydrogen Peroxide","Hydrogen Peroxide","D006861","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1996,"8798498","Molecular chlorine generated by the myeloperoxidase-hydrogen peroxide-chloride system of phagocytes converts low density lipoprotein cholesterol into a family of chlorinated sterols.","8798498",136]
["Hydrogen Peroxide","Hydrogen Peroxide","D006861","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2015,"25670494","Exogenous Superoxide Dismutase Mimetic Without Scavenging H2O2 Causes Photoreceptor Damage in a Rat Model for Oxygen-Induced Retinopathy.","25670494",136]
["Hydrogen Sulfide","Hydrogen Sulfide","D006862","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28251688","Inhibition of ALDH2 protects PC12 cells against formaldehyde-induced cytotoxicity: involving the protection of hydrogen sulphide.","28251688",136]
["Hydrogen Sulfide","Hydrogen Sulfide","D006862","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23129058","Protective effects of hydrogen sulfide on oxidative stress and fibrosis in hepatic stellate cells.","23129058",136]
["Hydrogen Sulfide","Hydrogen Sulfide","D006862","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2013,"23658335","Impact of source of sulfur on ruminal hydrogen sulfide and logic for the ruminal available sulfur for reduction concept.","23658335",136]
["hydroquinone","hydroquinone","C031927","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2017,"28836394","Reduced Nrf2 activation in PI3K phosphorylation-impaired vitiliginous keratinocytes increases susceptibility to ROS-generating chemical-induced apoptosis.","28836394",136]
["hydroxyapatite-beta tricalcium phosphate","hydroxyapatite-beta tricalcium phosphate","C074950","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24014247","Biphasic calcium phosphate loading on polycaprolactone/poly(lacto-co-glycolic acid) membranes for improved tensile strength, in vitro biocompatibility, and in vivo tissue regeneration.","24014247",136]
["hydroxyethyl methacrylate","hydroxyethyl methacrylate","C005044","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2013,"23229857","Infection-responsive drug delivery from urinary biomaterials controlled by a novel kinetic and thermodynamic approach.","23229857",136]
["hydroxygenkwanin","hydroxygenkwanin","C051414","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2009,"19604541","The effects of twelve representative flavonoids on tissue factor expression in human monocytes: structure-activity relationships.","19604541",136]
["Hydroxyl Radical","Hydroxyl Radical","D017665","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2008,"19031904","Removal of ammonia by OH radical in aqueous phase.","19031904",136]
["hydroxypropyl methacrylate","hydroxypropyl methacrylate","C032802","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25596326","Multivalent display of pendant pro-apoptotic peptides increases cytotoxic activity.","25596326",136]
["hydroxypropylcellulose","hydroxypropylcellulose","C008079","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2009,"19294306","A general microchip surface modification approach using a spin-coated polymer resist film doped with hydroxypropyl cellulose.","19294306",136]
["Hydroxyurea","Hydroxyurea","D006918","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,1994,"7809921","Inhibition of leukotriene B4 synthesis does not prevent development of acute renal failure following storage and transplantation.","7809921",136]
["hyperforin","hyperforin","C001654","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"26386573","The acylphloroglucinols hyperforin and myrtucommulone A cause mitochondrial dysfunctions in leukemic cells by direct interference with mitochondria.","26386573",136]
["hyperoside","hyperoside","C021304","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27041460","Hyperoside exerts anti-inflammatory and anti-arthritic effects in LPS-stimulated human fibroblast-like synoviocytes in vitro and in mice with collagen-induced arthritis.","27041460",136]
["Hypochlorous Acid","Hypochlorous Acid","D006997","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2001,"11690564","An alternative signaling pathway based on nitryl chloride during intercellular induction of apoptosis.","11690564",136]
["ibandronic acid","ibandronic acid","C073007","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,1996,"8889848","Bisphosphonates induce apoptosis in mouse macrophage-like cells in vitro by a nitric oxide-independent mechanism.","8889848",136]
["Ibuprofen","Ibuprofen","D007052","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2006,"16730702","Evidence of COX-2 independent induction of apoptosis and cell cycle block in human colon carcinoma cells after S- or R-ibuprofen treatment.","16730702",136]
["Ibuprofen","Ibuprofen","D007052","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Nasal Mucosa","D009297","Nasal Mucosa",1,2,1990,"2126915","Effect of a single dose of a topical glucocorticoid and a cyclo-oxygenase inhibitor on allergen-induced changes in nasal reactivity.","2126915",136]
["icaritin","icaritin","C499403","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2016,"27491234","[Inhibition of Combination of Icaritin and Doxorubicin on Human Osteosarcoma MG-63 Cells in vitro].","27491234",136]
["Ice","Ice","D007053","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2016,"27343137","Effects of micro electric current load during cooling of plant tissues on intracellular ice crystal formation behavior and pH.","27343137",136]
["Idremcinal","Idremcinal","C090116","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"17183187","In vitro pharmacological characterization of mitemcinal (GM-611), the first acid-resistant non-peptide motilin receptor agonist, in smooth muscle of rabbit small intestine.","17183187",136]
["Imatinib Mesylate","Imatinib Mesylate","D000068877","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2002,"12231544","Flavopiridol potentiates STI571-induced mitochondrial damage and apoptosis in BCR-ABL-positive human leukemia cells.","12231544",136]
["Imatinib Mesylate","Imatinib Mesylate","D000068877","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2007,"17957275","Combined effects of doxorubicin and STI571 on growth, differentiation and apoptosis of CML cell line K562.","17957275",136]
["Imatinib Mesylate","Imatinib Mesylate","D000068877","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"20703259","HH-GV-678, a novel selective inhibitor of Bcr-Abl, outperforms imatinib and effectively overrides imatinib resistance.","20703259",136]
["Imatinib Mesylate","Imatinib Mesylate","D000068877","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"27718039","4-methylumbelliferone and imatinib combination enhances senescence induction in chronic myeloid leukemia cell lines.","27718039",136]
["Imatinib Mesylate","Imatinib Mesylate","D000068877","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21240485","Immunocompetent cell functions in Ph+ acute lymphoblastic leukemia patients on prolonged Imatinib maintenance treatment.","21240485",136]
["Imatinib Mesylate","Imatinib Mesylate","D000068877","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"24009732","The conformational control inhibitor of tyrosine kinases DCC-2036 is effective for imatinib-resistant cells expressing T674I FIP1L1-PDGFRα.","24009732",136]
["imazapyr","imazapyr","C076656","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,1,2012,"22430369","Comparability of imazapyr-resistant Arabidopsis created by transgenesis and mutagenesis.","22430369",136]
["imidazopyridinyl-1,3,4-oxadiazole","imidazopyridinyl-1,3,4-oxadiazole","C000620897","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27656775","Synthesis and biological evaluation of imidazopyridinyl-1,3,4-oxadiazole conjugates as apoptosis inducers and topoisomerase IIα inhibitors.","27656775",136]
["imiquimod","imiquimod","C056493","7_AO",872,7,"Site of Contact Nasal Tumors","Increase","Nose Neoplasms","D009669","Nose Neoplasms",1,1,2010,"20402949","Letter: Imiquimod 5% cream as adjunctive therapy for primary, solitary, nodular basal cell carcinomas before Mohs micrographic surgery: a randomized, double-blind, vehicle-controlled study.","20402949",136]
["imperatorin","imperatorin","C031534","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23497884","Biotransformation of imperatorin by Penicillium janthinellum. Anti-osteoporosis activities of its metabolites.","23497884",136]
["Indinavir","Indinavir","D019469","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1998,"9823864","Indinavir crystalluria: identification of patients at increased risk of developing nephrotoxicity.","9823864",136]
["Indocyanine Green","Indocyanine Green","D007208","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,1992,"1280499","Clinical evaluation of indocyanine green video-angiography in the diagnosis of choroidal neovascular membrane associated with age-related macular degeneration.","1280499",136]
["indole","indole","C030374","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25787158","Indole diketopiperazines from endophytic Chaetomium sp 88194 induce breast cancer cell apoptotic death.","25787158",136]
["indole-3-carbinol","indole-3-carbinol","C016517","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21044624","Indole-3-carbinol inhibits hepatic stellate cells proliferation by blocking NADPH oxidase/reactive oxygen species/p38 MAPK pathway.","21044624",136]
["indoline-2,3-dione","indoline-2,3-dione","C572590","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"26100440","Design, synthesis and preliminary biological evaluation of indoline-2,3-dione derivatives as novel HDAC inhibitors.","26100440",136]
["Indomethacin","Indomethacin","D007213","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2004,"15482327","Nimesulide and indomethacin induce apoptosis in head and neck cancer cells.","15482327",136]
["Indomethacin","Indomethacin","D007213","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,3,2008,"18067189","Physicochemical characterization, in vitro, and in vivo evaluation of indomethacin-loaded nanocarriers self-assembled by amphiphilic polyphosphazene.","18067189",136]
["Indoxamycin D","Indoxamycin D","C545168","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"19572603","Indoxamycins A-F. Cytotoxic tricycklic polypropionates from a marine-derived actinomycete.","19572603",136]
["Industrial Waste","Industrial Waste","D007220","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2004,"15604785","Biodegradation and detoxification of nicotine in tobacco solid waste by a Pseudomonas sp.","15604785",136]
["Industrial Waste","Industrial Waste","D007220","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2006,"16752774","Dissolved air flotation of polishing wastewater from semiconductor manufacturer.","16752774",136]
["Industrial Waste","Industrial Waste","D007220","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"17513041","Removal of Cr(VI) from industrial wastewaters by adsorption Part I: determination of optimum conditions.","17513041",136]
["Industrial Waste","Industrial Waste","D007220","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2009,"19195776","The pH-dependent leaching of inorganic contaminants from secondary lead smelter fly ash.","19195776",136]
["Industrial Waste","Industrial Waste","D007220","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2011,"21444152","Recovery of alumina and alkali in Bayer red mud by the formation of andradite-grossular hydrogarnet in hydrothermal process.","21444152",136]
["Industrial Waste","Industrial Waste","D007220","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"22666107","Usefulness of organic acid produced by Exiguobacterium sp. 12/1 on neutralization of alkaline wastewater.","22666107",136]
["Industrial Waste","Industrial Waste","D007220","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2017,"27095583","Treatment of Tannery Effluent Using a Rotating Disc Electrochemical Reactor.","27095583",136]
["Inositol","Inositol","D007294","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25345501","Inositol synthesis regulates the activation of GSK-3α in neuronal cells.","25345501",136]
["Inositol","Inositol","D007294","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1973,"4541513","Inhibition of  -galactosidase of mammalian tissues by myoinositol.","4541513",136]
["Inulin","Inulin","D007444","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"22743314","Inulin modifies the bifidobacteria population, fecal lactate concentration, and fecal pH but does not influence iron absorption in women with low iron status.","22743314",136]
["invert sugar","invert sugar","C008133","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"17222551","Alkaline degradation of invert sugar from molasses.","17222551",136]
["Iohexol","Iohexol","D007472","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2002,"12374914","Assessment of perfusion of facial microvascular transplants and early detection of ischemia by perfusion-CT scan.","12374914",136]
["Iopamidol","Iopamidol","D007479","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1983,"6862812","Urographic excretion studies with nonionic contrast agents. Iopamidol vs. iothalamate.","6862812",136]
["irbesartan","irbesartan","C081309","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2007,"17509562","Importance of intracellular angiotensin II in vascular smooth muscle cell apoptosis: inhibition by the angiotensin AT1 receptor antagonist irbesartan.","17509562",136]
["irinotecan","irinotecan","C051890","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"24065488","Radiation enhancing effects with the combination of sanazole and irinotecan in hypoxic HeLa human cervical cancer cell line.","24065488",136]
["irinotecan","irinotecan","C051890","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23299391","Preclinical antitumor activity of a nanoparticulate SN38.","23299391",136]
["Isatin","Isatin","D007510","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"25174967","The endogenous oxindole isatin induces apoptosis of MCF‑7 breast cancer cells through a mitochondrial pathway.","25174967",136]
["Isatin","Isatin","D007510","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1992,"1510706","Inhibitory potency of some isatin analogues on human monoamine oxidase A and B.","1510706",136]
["isofagomine","isofagomine","C098432","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2017,"27750150","(5aR)-5a-C-Pentyl-4-epi-isofagomine: A powerful inhibitor of lysosomal β-galactosidase and a remarkable chaperone for mutations associated with GM1-gangliosidosis and Morquio disease type B.","27750150",136]
["Isoflurane","Isoflurane","D007530","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2012,"23109161","Balanced anesthesia-baseline anesthesia.","23109161",136]
["isoliquiritigenin","isoliquiritigenin","C040920","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"24214831","Isoliquiritigenin induces caspase-dependent apoptosis via downregulation of HPV16 E6 expression in cervical cancer Ca Ski cells.","24214831",136]
["isoliquiritigenin 2'-methyl ether","isoliquiritigenin 2'-methyl ether","C550177","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"20040371","Isoliquiritigenin 2'-methyl ether induces growth inhibition and apoptosis in oral cancer cells via heme oxygenase-1.","20040371",136]
["Isoniazid","Isoniazid","D007538","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,1962,"14003878","[Intrauterine fetal necrosis due to the use of isonicotinic acid hydrazide in pregnant women].","14003878",136]
["Isoproterenol","Isoproterenol","D007545","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21554097","Chronic β-adrenergic stimulation increases ErbB receptors and cell proliferation in mouse kidney.","21554097",136]
["Isoproterenol","Isoproterenol","D007545","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,1986,"3783726","Sodium nitrite protects against isoproterenol-induced myocardial necrosis.","3783726",136]
["Isoproterenol","Isoproterenol","D007545","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,1970,"5410410","Myocardial resistance. A study of its development against toxic doses of isoproterenol.","5410410",136]
["isothiochroman","isothiochroman","C011292","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2005,"15664843","Estrogen receptor ligands. Part 11: Synthesis and activity of isochromans and isothiochromans.","15664843",136]
["Isradipine","Isradipine","D017275","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2009,"19385055","Isradipine antagonizes hypobaric hypoxia induced CA1 damage and memory  impairment: Complementary roles of L-type calcium channel and NMDA receptors.","19385055",136]
["Itraconazole","Itraconazole","D017964","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21936514","Itraconazole side chain analogues: structure-activity relationship studies for inhibition of endothelial cell proliferation, vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, and hedgehog signaling.","21936514",136]
["jasmonic acid","jasmonic acid","C011006","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25637374","Elevated levels of CYP94 family gene expression alleviate the jasmonate response and enhance salt tolerance in rice.","25637374",136]
["juglanin","juglanin","C000590800","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"27899257","Juglanin induces apoptosis and autophagy in human breast cancer progression via ROS/JNK promotion.","27899257",136]
["kaempferol","kaempferol","C006552","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2000,"11197066","Glucuronidation of resveratrol, a natural product present in grape and wine, in the human liver.","11197066",136]
["Kainic Acid","Kainic Acid","D007608","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,1990,"1971710","Neurologic sequelae of domoic acid intoxication due to the ingestion of contaminated mussels.","1971710",136]
["kang-lai-te","kang-lai-te","C499781","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2009,"19502166","Experimental study on the effect of Kang-Lai-Te induced apoptosis of human hepatoma carcinoma cell HepG2.","19502166",136]
["kaurenoic acid","kaurenoic acid","C051436","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1996,"8806729","Hydroxylation of ent-kaurenoic acid to steviol in Stevia rebaudiana Bertoni--purification and partial characterization of the enzyme.","8806729",136]
["Ketamine","Ketamine","D007649","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2010,"19725066","The toxic effect of ketamine on SH-SY5Y neuroblastoma cell line and human neuron.","19725066",136]
["Ketamine","Ketamine","D007649","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2015,"26087832","Possible pathophysiology of ketamine-related cystitis and associated treatment strategies.","26087832",136]
["Ketoconazole","Ketoconazole","D007654","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,1998,"9864540","[Acute hepatocytic necrosis during ketoconazole therapy for treatment of onychomycosis. National Foundation for Registry and Evaluation of Adverse Effects].","9864540",136]
["Ketorolac Tromethamine","Ketorolac Tromethamine","D020911","7_AO",872,7,"Site of Contact Nasal Tumors","Increase","Nose","D009666","Nose",1,3,2010,"20884857","A novel formulation of ketorolac tromethamine for intranasal administration: preclinical safety evaluation.","20884857",136]
["kotomolide A","kotomolide A","C512093","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2006,"16792412","Chemical and cytotoxic constituents from the leaves of Cinnamomum kotoense.","16792412",136]
["KPT-185","KPT-185","C576639","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23079374","CRM1 blockade by selective inhibitors of nuclear export attenuates kidney cancer growth.","23079374",136]
["kutkin","kutkin","C057463","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"20846525","Immunomodulatory effect of picroliv on the efficacy of paromomycin and miltefosine in combination in experimental visceral leishmaniasis.","20846525",136]
["Lactic Acid","Lactic Acid","D019344","1_MIE",867,1,"Intracellular pH","Decrease","Acid-Base Equilibrium","D000136","Acid-Base Equilibrium",2,2,1985,"4009383","The concentration of hypoxanthine and lactate in the blood of healthy and hypoxic newborns.","4009383",136]
["Lactic Acid","Lactic Acid","D019344","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"26484566","Targeting metabolic flexibility by simultaneously inhibiting respiratory complex I and lactate generation retards melanoma progression.","26484566",136]
["Lactic Acid","Lactic Acid","D019344","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Atrophy","D001284","Atrophy",1,1,2006,"17085222","Sculptra: the new three-dimensional filler.","17085222",136]
["Lactic Acid","Lactic Acid","D019344","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2010,"19821075","Post-culture treatment protocols for PLGA membrane scaffolds.","19821075",136]
["Lactic Acid","Lactic Acid","D019344","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2014,"24411397","Electrospun nanofibrous scaffolds of poly (L-lactic acid)-dicalcium silicate composite via ultrasonic-aging technique for bone regeneration.","24411397",136]
["Lactic Acid","Lactic Acid","D019344","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"25337186","Promotion of initial anti-tumor effect via polydopamine modified doxorubicin-loaded electrospun fibrous membranes.","25337186",136]
["Lactic Acid","Lactic Acid","D019344","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1999,"10030795","Beneficial effects of L-canavanine, a selective inhibitor of inducible nitric oxide synthase, on lactate metabolism and muscle high energy phosphates during endotoxic shock in rats.","10030795",136]
["Lactic Acid","Lactic Acid","D019344","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2004,"15189287","Typical metabolic traits of two Oenococcus oeni strains isolated from Valpolicella wines.","15189287",136]
["Lactic Acid","Lactic Acid","D019344","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2008,"18456356","Physiological state of single cells of Listeria innocua in organic acids.","18456356",136]
["Lactic Acid","Lactic Acid","D019344","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2009,"19073244","Encapsulated zinc salt increases the diffusion of protein through PLG films.","19073244",136]
["Lactic Acid","Lactic Acid","D019344","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"22770568","Biocompatibility and degradation characteristics of PLGA-based electrospun nanofibrous scaffolds with nanoapatite incorporation.","22770568",136]
["Lactic Acid","Lactic Acid","D019344","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2015,"26437637","Pre-alcoholic fermentation acidification of red grape must using Lactobacillus plantarum.","26437637",136]
["Lactic Acid","Lactic Acid","D019344","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1982,"7125656","Effect of pH on growth rates of rumen amylolytic and lactilytic bacteria.","7125656",136]
["Lactic Acid","Lactic Acid","D019344","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1996,"8910195","The mechanisms controlling physiologically stimulated changes in rat brain glucose and lactate: a microdialysis study.","8910195",136]
["Lactic Acid","Lactic Acid","D019344","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2000,"10813866","Differences in water diffusion and lactate production in two different types of postinfectious encephalopathy.","10813866",136]
["Lactose","Lactose","D007785","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1964,"14216060","PURIFICATION AND SOME PROPERTIES OF BETA-GLACTOSIDASE OF BACILLUS SUBTILIS.","14216060",136]
["Lactose","Lactose","D007785","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1970,"5525214","[Milk intolerance syndrome. Correlation between the clinical antecedents and the lactose, lactic acid and fecal pH curves].","5525214",136]
["Lactulose","Lactulose","D007792","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1985,"3973020","Influence of chronic lactulose ingestion on the colonic metabolism of lactulose in man (an in vivo study).","3973020",136]
["landomycin O","landomycin O","C503608","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2005,"15812784","Generation of novel landomycins M and O through targeted gene disruption.","15812784",136]
["lapatinib","lapatinib","C490728","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"24909179","PRKACA mediates resistance to HER2-targeted therapy in breast cancer cells and restores anti-apoptotic signaling.","24909179",136]
["laromustine","laromustine","C483604","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2009,"19328547","Laromustine: the return of alkylators to non-myeloablative therapy of AML.","19328547",136]
["Latex","Latex","D007840","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1964,"14209945","FICUS ENZYMES. II. PROPERTIES OF THE PROTEOLYTIC ENZYMES FROM THE LATEX OF FICUS CARICA VARIETY KADOTA.","14209945",136]
["LC-002","LC-002","C000601390","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25988535","Water-Soluble Ruthenium(II) Complexes with Chiral 4-(2,3-Dihydroxypropyl)-formamide Oxoaporphine (FOA): In Vitro and in Vivo Anticancer Activity by Stabilization of G-Quadruplex DNA, Inhibition of Telomerase Activity, and Induction of Tumor Cell Apoptosis.","25988535",136]
["lenalidomide","lenalidomide","C467567","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"21080211","In vitro cytotoxicity of the novel antimyeloma agents perifosine, bortezomib and lenalidomide against different cell lines.","21080211",136]
["Leptophos","Leptophos","D010773","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1975,"57871","Chemistry and toxicology of pesticide chemicals. II. Stability of leptophos.","57871",136]
["letrozole","letrozole","C067431","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2014,"24410765","Inhibitory effects of aromatase inhibitor on estrogen receptor-alpha positive ovarian cancer in mice.","24410765",136]
["Leukotriene D4","Leukotriene D4","D017998","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Nasal Mucosa","D009297","Nasal Mucosa",1,2,2006,"16939879","Different mechanisms between thromboxane A2- and leukotriene D4-induced nasal blockage in guinea pigs.","16939879",136]
["Levofloxacin","Levofloxacin","D064704","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2013,"23846144","Photodegradation of levofloxacin in aqueous and organic solvents: a kinetic study.","23846144",136]
["levormeloxifene","levormeloxifene","C108255","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2008,"18184756","Changes in transcription profile and cytoskeleton morphology in pelvic ligament fibroblasts in response to stretch: the effects of estradiol and levormeloxifene.","18184756",136]
["LGP1 compound","LGP1 compound","C549428","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"20393011","LGP1, A histone deacetylase inhibitor analogue of FR235222, sensitizes promyelocytic leukaemia U937 cells to TRAIL-mediated apoptosis.","20393011",136]
["Lidocaine","Lidocaine","D008012","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2001,"11707790","Epidural fentanyl speeds the onset of sensory block during epidural lidocaine anesthesia.","11707790",136]
["Lidocaine","Lidocaine","D008012","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1975,"240301","The effect of local anesthetic, lidocaine, on guinea pig trachealis muscle in vitro.","240301",136]
["liensinine","liensinine","C080095","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"26219228","Isoliensinine induces apoptosis in triple-negative human breast cancer cells through ROS generation and p38 MAPK/JNK activation.","26219228",136]
["Lignin","Lignin","D008031","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2002,"12003313","Bio-degradation of lignin in olive pomace by freshly-isolated species of Basidiomycete.","12003313",136]
["Lignin","Lignin","D008031","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2015,"25498680","Augmented digestion of lignocellulose by steam explosion, acid and alkaline pretreatment methods: a review.","25498680",136]
["Lignin","Lignin","D008031","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1996,"8967777","Polymerization of pentachlorophenol and ferulic acid by fungal extracellular lignin-degrading enzymes.","8967777",136]
["lignocellulose","lignocellulose","C036909","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2017,"28078651","Fed-Batch Enzymatic Saccharification of High Solids Pretreated Lignocellulose for Obtaining High Titers and High Yields of Glucose.","28078651",136]
["lime","lime","C016538","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2017,"28095118","Modeling and optimization of lime-based stabilization in high alkaline arsenic-bearing sludges with a central composite design.","28095118",136]
["Lincomycin","Lincomycin","D008034","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1970,"5413733","Hydrolysis of lincomycin-2-phosphate and clindamycin-2-phosphate.","5413733",136]
["linsidomine","linsidomine","C002385","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2002,"11793158","Selective nitration of mitochondrial complex I by peroxynitrite: involvement in mitochondria dysfunction and cell death of dopaminergic SH-SY5Y cells.","11793158",136]
["linsidomine","linsidomine","C002385","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"21782928","Threshold of peroxynitrite cytotoxicity in bovine pulmonary artery endothelial and smooth muscle cells.","21782928",136]
["lipophosphonoglycan","lipophosphonoglycan","C008290","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1999,"10433687","Intra-species and stage-specific polymorphisms in lipophosphoglycan structure control Leishmania donovani-sand fly interactions.","10433687",136]
["lipoxin A4","lipoxin A4","C040527","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"26865215","Lipoxin A4 exerts protective effects against experimental acute liver failure by inhibiting the NF-κB pathway.","26865215",136]
["Lithium Chloride","Lithium Chloride","D018021","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23878501","Lithium chloride promotes host resistance against Pseudomonas aeruginosa keratitis.","23878501",136]
["Lithium Chloride","Lithium Chloride","D018021","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24107386","Lithium fails to enhance neurogenesis in subventricular zone and dentate subgranular zone after intracerebral hemorrhage in rats.","24107386",136]
["LMWH-DOCA conjugate","LMWH-DOCA conjugate","C521279","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,2,2014,"25003253","Combinational chemoprevention effect of celecoxib and an oral antiangiogenic LHD4 on colorectal carcinogenesis in mice.","25003253",136]
["Lopinavir","Lopinavir","D061466","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24012878","HIV protease inhibitor Lopinavir induces apoptosis of primary effusion lymphoma cells via suppression of NF-κB pathway.","24012878",136]
["Loratadine","Loratadine","D017336","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Nasal Mucosa","D009297","Nasal Mucosa",1,2,2003,"14710913","Effects of loratadine on red wine-induced symptoms and signs of rhinitis.","14710913",136]
["louisianin C","louisianin C","C096932","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,1997,"9127203","Efficient chemical conversion of louisianin A to C and D, the inhibitor of angiogenesis.","9127203",136]
["Lovastatin","Lovastatin","D008148","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1994,"8060342","Cytosolic Ca2+ increase and cell damage in L6 rat myoblasts by HMG-CoA reductase inhibitors.","8060342",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C198787,B198787)","v":"Luminol"},"Luminol","D008165","1_MIE",867,1,"Intracellular pH","Decrease",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J198787,K198787)","v":"Hydrogen-Ion Concentration"},"D006863","Hydrogen-Ion Concentration",2,2,1989,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q198787,Q198787)","v":"2617555"},"[The possibility for determining haptoglobin phenotypes in blood stains after treatment with a luminol solution].","2617555",136]
["lupeol","lupeol","C010480","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2007,"17340578","Hepatoprotective effects of lupeol and mango pulp extract of carcinogen induced alteration in Swiss albino mice.","17340578",136]
["Luteolin","Luteolin","D047311","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24846311","Luteolin modulates 6-hydroxydopamine-induced transcriptional changes of stress response pathways in PC12 cells.","24846311",136]
["LY 303511","LY 303511","C093555","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2013,"23239672","Computational modelling of LY303511 and TRAIL-induced apoptosis suggests dynamic regulation of cFLIP.","23239672",136]
["lycopene","lycopene","C015329","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22428115","Are lycopene metabolites metabolically active?","22428115",136]
["lycopene","lycopene","C015329","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28800556","Supplementation of lycopene in maturation media improves bovine embryo quality in vitro.","28800556",136]
["lysophosphatidic acid","lysophosphatidic acid","C032881","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2005,"16044162","Lysophosphatidic acid and endothelin-induced proliferation of ovarian cancer cell lines is mitigated by neutralization of granulin-epithelin precursor (GEP), a prosurvival factor for ovarian cancer.","16044162",136]
["lysophosphatidylserine","lysophosphatidylserine","C025059","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2013,"23293064","Neutrophils regulate tissue Neutrophilia in inflammation via the oxidant-modified lipid lysophosphatidylserine.","23293064",136]
["Magnesium Hydroxide","Magnesium Hydroxide","D008276","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2004,"15352917","Effects of effervescent ranitidine on gastric pH: comparison with almagate and placebo in fasting and postprandial conditions.","15352917",136]
["Magnesium Hydroxide","Magnesium Hydroxide","D008276","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1989,"2631570","[Drug interactions during storage of mixtures of the antacid group. II. Effect of temperature on the formation of hydrotalcite in neutralizing suspensions].","2631570",136]
["Magnesium Sulfate","Magnesium Sulfate","D008278","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2000,"10772057","Acute cord occlusion increases blood ionized magnesium concentration in preterm fetal sheep during maternal magnesium sulfate exposure.","10772057",136]
["malabaricone C","malabaricone C","C071787","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20805034","Comparative nuclease and anti-cancer properties of the naturally occurring malabaricones.","20805034",136]
["maleimide","maleimide","C043592","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22061108","Maleimide-thiol coupling of a bioactive peptide to an elastin-like protein polymer.","22061108",136]
["malic acid","malic acid","C030298","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2002,"11891579","Regulation of the lemon-fruit V-ATPase by variable stoichiometry and organic acids.","11891579",136]
["Malondialdehyde","Malondialdehyde","D008315","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1983,"6644387","Electrophoretic study on the DNA-breaking actions of ascorbic acid and triose reductone in the presence of Cu2+.","6644387",136]
["maltotriose","maltotriose","C008317","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1992,"1592801","Haloalkaliphilic maltotriose-forming alpha-amylase from the archaebacterium Natronococcus sp. strain Ah-36.","1592801",136]
["manganese chloride","manganese chloride","C025340","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1982,"6949675","Comparative study on glycosaminoglycan-sulfotransferases in rat costal cartilage and chick embryo cartilage.","6949675",136]
["manganese dioxide","manganese dioxide","C016552","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2015,"26111516","Manganese Dioxide nanosheet suspension: A novel absorbent for Cadmium(II) contamination in waterbody.","26111516",136]
["mangiferin","mangiferin","C013592","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"25427663","Mangiferin attenuate sepsis-induced acute kidney injury via antioxidant and anti-inflammatory effects.","25427663",136]
["Mannitol","Mannitol","D008353","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1965,"14337983","RELATION OF ACUTE TUBULAR NECROSIS TO SHOCK AND THE EFFECT OF MANNITOL.","14337983",136]
["Mannitol","Mannitol","D008353","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1971,"5123226","On the mechanism of hyperkalaemia due to hyperosmotic expansion with saline or mannitol.","5123226",136]
["Mannose","Mannose","D008358","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1996,"8806782","Nitration of surfactant protein A (SP-A) tyrosine residues results in decreased mannose binding ability.","8806782",136]
["Manure","Manure","D008372","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2008,"17850320","Persistence of Shiga toxin-producing Escherichia coli O26 in various manure-amended soil types.","17850320",136]
["Manure","Manure","D008372","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2017,"27843088","Dry fermentation of manure with straw in continuous plug flow reactor: Reactor development and process stability at different loading rates.","27843088",136]
["Margarine","Margarine","D008383","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2003,"12696676","Viability of Salmonella, Escherichia coli O157:H7, and Listeria monocytogenes in yellow fat spreads as affected by storage temperature.","12696676",136]
["matairesinol","matairesinol","C068935","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2008,"19067377","Induction of apoptosis by a synergistic lignan composition from Cedrus deodara in human cancer cells.","19067377",136]
["matrine","matrine","C034244","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22207169","Inhibition of matrine against gastric cancer cell line MNK45 growth and its anti-tumor mechanism.","22207169",136]
["MCM-41","MCM-41","C509968","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2009,"18571846","Adsorption of anionic dyes on ammonium-functionalized MCM-41.","18571846",136]
["Measles Vaccine","Measles Vaccine","D008458","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Nasal Mucosa","D009297","Nasal Mucosa",1,1,1969,"5407008","[Experimental evaluation of the effectiveness of the aerosol method of measles immunization].","5407008",136]
["Mechlorethamine","Mechlorethamine","D008466","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"29174984","Efficacy of anti-inflammatory, antibiotic and pleiotropic agents in reversing nitrogen mustard- induced injury in ex vivo cultured rabbit cornea.","29174984",136]
["Medroxyprogesterone Acetate","Medroxyprogesterone Acetate","D017258","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23585406","Induction of rat germ cell apoptosis by testosterone undecanoate and depot medroxyprogesterone acetate and correlation of apoptotic cells with sperm concentration.","23585406",136]
["melamine","melamine","C011907","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22027504","Toxicity of melamine and cyanuric acid in broilers and residues in tissues.","22027504",136]
["meloxicam","meloxicam","C065757","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2006,"16417605","The in vitro effects of piroxicam and meloxicam on canine cell lines.","16417605",136]
["MEN 11467","MEN 11467","C121095","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2005,"16222150","Role of NK-1 and NK-2 tachykinin receptor antagonism on the growth of human breast carcinoma cell line MDA-MB-231.","16222150",136]
["Meperidine","Meperidine","D008614","7_AO",872,7,"Site of Contact Nasal Tumors","Increase","Nose","D009666","Nose",1,1,1991,"1853688","A comparison of intravenous ketoprofen with pethidine for postoperative pain relief following nasal surgery.","1853688",136]
["Mercaptopurine","Mercaptopurine","D015122","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1991,"1912333","Reaction of a chemotherapeutic agent, 6-mercaptopurine, with a direct-acting, electrophilic carcinogen, benzo[a]pyrene-7,8-diol 9,10-epoxide.","1912333",136]
["Mercuric Chloride","Mercuric Chloride","D008627","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,1995,"7867075","Mercuric chloride-induced programmed cell death of a murine T cell hybridoma. II. Opposite effect of interleukin-2 and interleukin-4.","7867075",136]
["Mesalamine","Mesalamine","D019804","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25429050","Mesalazine and thymoquinone attenuate intestinal tumour development in Msh2(loxP/loxP) Villin-Cre mice.","25429050",136]
["Metaproterenol","Metaproterenol","D009921","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1974,"4435354","[Inhibition of labour prior to caesarian section during labour (author's transl)].","4435354",136]
["Metformin","Metformin","D008687","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"21881601","Metformin inhibits melanoma development through autophagy and apoptosis mechanisms.","21881601",136]
["Metformin","Metformin","D008687","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"26435693","AICAR and Metformin Exert AMPK-dependent Effects on INS-1E Pancreatic β-cell Apoptosis via Differential Downstream Mechanisms.","26435693",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C205763,B205763)","v":"Metformin"},"Metformin","D008687","3_KE",870,3,"Cell Proliferation","Increase",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J205763,K205763)","v":"Cell Proliferation"},"D049109","Cell Proliferation",1,2,2013,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q205763,Q205763)","v":"23891087"},"Contributions of AMPK and p53 dependent signaling to radiation response in the presence of metformin.","23891087",136]
["Metformin","Metformin","D008687","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28183442","High-dose metformin (420mg/kg daily p.o.) increases insulin sensitivity but does not affect neointimal thickness in the rat carotid balloon injury model of restenosis.","28183442",136]
["Metformin","Metformin","D008687","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28975647","Effect of metformin and celecoxib on cytotoxicity and release of GDF-15 from human mesenchymal stem cells in high glucose condition.","28975647",136]
["Methadone","Methadone","D008691","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2008,"18676827","Methadone, commonly used as maintenance medication for outpatient treatment of opioid dependence, kills leukemia cells and overcomes chemoresistance.","18676827",136]
["Methamphetamine","Methamphetamine","D008694","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2017,"28249787","Effects of prolonged abstinence from METH on the hippocampal BDNF levels, neuronal numbers and apoptosis in methamphetamine-sensitized rats.","28249787",136]
["Methane","Methane","D008697","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"26711852","Neuroprotective effects of exogenous methane in a rat model of acute carbon monoxide poisoning.","26711852",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C206723,B206723)","v":"Methane"},"Methane","D008697","1_MIE",867,1,"Intracellular pH","Decrease",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J206723,K206723)","v":"Hydrogen-Ion Concentration"},"D006863","Hydrogen-Ion Concentration",2,2,2006,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q206723,Q206723)","v":"16699521"},"Isolation of a novel acidiphilic methanogen from an acidic peat bog.","16699521",136]
["Methane","Methane","D008697","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"24291758","Influences of the substrate feeding regime on methanogenic activity in biogas reactors approached by molecular and stable isotope methods.","24291758",136]
["Methanol","Methanol","D000432","1_MIE",867,1,"Intracellular pH","Decrease","Acid-Base Equilibrium","D000136","Acid-Base Equilibrium",2,2,2005,"16230297","[Acute methanol poisoning: about one case].","16230297",136]
["Methanol","Methanol","D000432","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2002,"12115407","Fermentation strategies for improved heterologous expression of laccase in Pichia pastoris.","12115407",136]
["Methanol","Methanol","D000432","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1988,"3284121","[The nature of methanol-induced acidification of the medium by products of metabolism of methylotrophic yeasts].","3284121",136]
["methenamine mandelate","methenamine mandelate","C023055","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1989,"2492288","Recurrent bacteriuria: 1. Prior therapy.","2492288",136]
["Methocarbamol","Methocarbamol","D008721","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1994,"8046603","Methocarbamol degradation in aqueous solution.","8046603",136]
["Methotrexate","Methotrexate","D008727","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2007,"16998802","Methotrexate-induced mucositis in mucin 2-deficient mice.","16998802",136]
["Methotrexate","Methotrexate","D008727","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"19548002","Adenovirally mediated p53 overexpression diversely influence the cell cycle of HEp-2 and CAL 27 cell lines upon cisplatin and methotrexate treatment.","19548002",136]
["Methotrexate","Methotrexate","D008727","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1985,"3933559","Binding of methotrexate to dihydrofolate reductase and its relation to protonation of the ligand.","3933559",136]
["Methoxsalen","Methoxsalen","D008730","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,1996,"8628746","PUVA treatment selectively induces a cell cycle block and subsequent apoptosis in human T-lymphocytes.","8628746",136]
["Methoxyflurane","Methoxyflurane","D008733","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1975,"238545","Nuclear magnetic resonance studies of anaesthetic interactions with haemoglobin.","238545",136]
["Methoxyhydroxyphenylglycol","Methoxyhydroxyphenylglycol","D008734","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Atrophy","D001284","Atrophy",1,1,1979,"453776","Monoamine metabolite levels in cerebrospinal fluid and brain atrophy in lobotomized schizophrenic patients.","453776",136]
["methyl farnesoate","methyl farnesoate","C032429","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1991,"2055434","Characterization of a methyl farnesoate binding protein in hemolymph from Libinia emarginata.","2055434",136]
["Methyl Methanesulfonate","Methyl Methanesulfonate","D008741","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2007,"17603010","Alkylating agent methyl methanesulfonate (MMS) induces a wave of global protein hyperacetylation: implications in cancer cell death.","17603010",136]
["Methyl n-Butyl Ketone","Methyl n-Butyl Ketone","D008742","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25797582","Methyl isobutyl ketone exposure-related increases in specific measures of α2u-globulin (α2u) nephropathy in male rats along with in vitro evidence of reversible protein binding.","25797582",136]
["methyl tert-butyl ether","methyl tert-butyl ether","C043243","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"17553546","Electrocatalytic oxidation of methyl tert-butyl ether (MTBE) in aqueous solution at a nickel electrode.","17553546",136]
["Methylcellulose","Methylcellulose","D008747","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2011,"21959817","Development of meloxicam formulations utilizing ternary complexation for solubility enhancement.","21959817",136]
["Methylene Blue","Methylene Blue","D008751","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"19751777","Nanoparticle-mediated combination chemotherapy and photodynamic therapy overcomes tumor drug resistance.","19751777",136]
["Methylene Blue","Methylene Blue","D008751","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"24905046","Determination of methylene blue biosorption by Rhizopus arrhizus in the presence of surfactants with different chemical structures.","24905046",136]
["Methylene Blue","Methylene Blue","D008751","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2016,"27973361","Lotus seedpod as a low-cost biomass for potential methylene blue adsorption.","27973361",136]
["methylfructoside","methylfructoside","C099954","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1996,"8678485","Selectivity of methyl-fructoside synthesis with beta-fructofuranosidase.","8678485",136]
["methylmethacrylate-methacrylic acid copolymer","methylmethacrylate-methacrylic acid copolymer","C038300","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2010,"20800682","The use of dynamic mechanical analysis (DMA) to evaluate plasticization of acrylic polymer films under simulated gastrointestinal conditions.","20800682",136]
["methylnaltrexone","methylnaltrexone","C032257","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2009,"19322519","Use of FDA approved methamphetamine to allow adjunctive use of methylnaltrexone to mediate core anti-growth factor signaling effects in glioblastoma.","19322519",136]
["methylparaben","methylparaben","C015358","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23479059","A study of parabens and bisphenol A in surface water and fish brain tissue from the Greater Pittsburgh Area.","23479059",136]
["Methylprednisolone","Methylprednisolone","D008775","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2008,"18326537","Prevention of corticosteroid-induced osteonecrosis in rabbits by intra-bone marrow injection of autologous bone marrow cells.","18326537",136]
["methylprednisolone acetate","methylprednisolone acetate","C000873","7_AO",872,7,"Site of Contact Nasal Tumors","Increase","Nose Neoplasms","D009669","Nose Neoplasms",1,1,2002,"12055481","Retinal and choroidal microvascular embolization with methylprednisolone.","12055481",136]
["methylselenic acid","methylselenic acid","C008493","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2002,"12112305","Induction of caspase-mediated apoptosis and cell-cycle G1 arrest by selenium metabolite methylselenol.","12112305",136]
["Metoclopramide","Metoclopramide","D008787","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Nasal Mucosa","D009297","Nasal Mucosa",1,2,2006,"16942844","Rapid-onset intranasal delivery of metoclopramide hydrochloride. Part I. Influence of formulation variables on drug absorption in anesthetized rats.","16942844",136]
["Metronidazole","Metronidazole","D008795","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"24641528","Metronidazole and Pentoxifylline films for the local treatment of chronic periodontal pockets: preparation, in vitro evaluation and clinical assessment.","24641528",136]
["mevalonolactone","mevalonolactone","C015367","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1997,"9208099","Feasibility of an immunoassay for mevalonolactone.","9208099",136]
["Mexiletine","Mexiletine","D008801","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1993,"8436157","Influence of debrisoquine hydroxylation phenotype on the pharmacokinetics of mexiletine.","8436157",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C212227,B212227)","v":"Miconazole"},"Miconazole","D008825","1_MIE",867,1,"Intracellular pH","Decrease",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J212227,K212227)","v":"Hydrogen-Ion Concentration"},"D006863","Hydrogen-Ion Concentration",2,2,1976,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q212227,Q212227)","v":"7188"},"Mechanism of action of miconazole: labilization of rat liver lysosomes in vitro by miconazole.","7188",136]
["Mifepristone","Mifepristone","D015735","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2008,"18004570","In vitro evaluation of the growth inhibition and apoptosis effect of mifepristone (RU486) in human Ishikawa and HEC1A endometrial cancer cell lines.","18004570",136]
["Mifepristone","Mifepristone","D015735","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2007,"17671693","Downregulation of retinoblastoma protein is involved in the enhanced cytotoxicity of 4-hydroxytamoxifen plus mifepristone combination therapy versus antiestrogen monotherapy of human breast cancer.","17671693",136]
["mineral trioxide aggregate","mineral trioxide aggregate","C086631","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"25069932","Effects of calcium silicate endodontic cements on biocompatibility and mineralization-inducing potentials in human dental pulp cells.","25069932",136]
["Minocycline","Minocycline","D008911","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22583533","Anti-apoptotic and anti-oxidative mechanisms of minocycline against sphingomyelinase/ceramide neurotoxicity: implication in Alzheimer's disease and cerebral ischemia.","22583533",136]
["mirtazapine","mirtazapine","C035133","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Atrophy","D001284","Atrophy",1,1,2016,"26806603","Pharmacological treatment with mirtazapine rescues cortical atrophy and respiratory deficits in MeCP2 null mice.","26806603",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C213187,B213187)","v":"Misoprostol"},"Misoprostol","D016595","5_KE",768,5,"Cytotoxicity","Increase",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J213187,K213187)","v":"Apoptosis"},"D017209","Apoptosis",1,2,2007,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q213187,Q213187)","v":"17433419"},"The effect of Misoprostol, a prostaglandin E1 analog, on apoptosis in ischemia-reperfusion-induced intestinal injury.","17433419",136]
["Mitomycin","Mitomycin","D016685","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1992,"1510975","Bioreductive activation of mitomycin C by DT-diaphorase.","1510975",136]
["Mitomycin","Mitomycin","D016685","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2002,"11820665","Hyperbaric oxygen therapy for mitomycin C-induced scleral necrosis.","11820665",136]
["MK 0591","MK 0591","C078266","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25875826","MK591, a second generation leukotriene biosynthesis inhibitor, prevents invasion and induces apoptosis in the bone-invading C4-2B human prostate cancer cells: implications for the treatment of castration-resistant, bone-metastatic prostate cancer.","25875826",136]
["MK-1775","MK-1775","C549567","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25308916","Targeting histone deacetylases (HDACs) and Wee1 for treating high-risk neuroblastoma.","25308916",136]
["Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin","Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin","C502230","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2010,"20735206","Metalloporphyrin synergizes with ascorbic acid to inhibit cancer cell growth through fenton chemistry.","20735206",136]
["monastrol","monastrol","C400223","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2007,"17210704","Potentiation of kinesin spindle protein inhibitor-induced cell death by modulation of mitochondrial and death receptor apoptotic pathways.","17210704",136]
["mono-(2-ethylhexyl)phthalate","mono-(2-ethylhexyl)phthalate","C016599","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24836450","Mono-(2-ethylhexyl) phthalate induces injury in human umbilical vein endothelial cells.","24836450",136]
["monomethoxypolyethylene glycol","monomethoxypolyethylene glycol","C028210","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"25489242","A novel diblock of copolymer of (monomethoxy poly [ethylene glycol]-oleate) with a small hydrophobic fraction to make stable micelles/polymersomes for curcumin delivery to cancer cells.","25489242",136]
["monomethylarsonic acid","monomethylarsonic acid","C020300","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2004,"15461159","Arsenic speciation of solvent-extracted leachate from new and weathered CCA-treated wood.","15461159",136]
["morin","morin","C008548","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"25446498","Synthesis and characterisation of morin reduced gold nanoparticles and its cytotoxicity in MCF-7 cells.","25446498",136]
["Morphine","Morphine","D009020","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2013,"24134439","Cytoprotective effects of opioids on irradiated oral epithelial cells.","24134439",136]
["Morphine","Morphine","D009020","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1995,"8537369","Acetyl coenzyme A:salutaridinol-7-O-acetyltransferase from papaver somniferum plant cell cultures. The enzyme catalyzing the formation of thebaine in morphine biosynthesis.","8537369",136]
["morpholinopropane sulfonic acid","morpholinopropane sulfonic acid","C008550","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2017,"27940223","MOPS and coxsackievirus B3 stability.","27940223",136]
["Mumps Vaccine","Mumps Vaccine","D009108","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2005,"15885638","Correlates of lymphoproliferative responses to measles, mumps, and rubella (MMR) virus vaccines following MMR-II vaccination in healthy children.","15885638",136]
["muscone","muscone","C031021","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2016,"26473795","Effects of Muscone on Random Skin Flap Survival in Rats.","26473795",136]
["Mycobacterium tuberculosis antigens","Mycobacterium tuberculosis antigens","C072681","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25544271","Mycobacterium tuberculosis 38-kDa antigen induces endoplasmic reticulum stress-mediated apoptosis via toll-like receptor 2/4.","25544271",136]
["Mycophenolic Acid","Mycophenolic Acid","D009173","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"26529468","Synthesis and Characterization of a Novel Mycophenolic Acid-Quinic Acid Conjugate Serving as Immunosuppressant with Decreased Toxicity.","26529468",136]
["Myristic Acid","Myristic Acid","D019814","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2012,"21965604","Tandem reporter assay for myristoylated proteins post-translationally (TRAMPP) identifies novel substrates for post-translational myristoylation: PKCε, a case study.","21965604",136]
["N(1),N(11)-diethylnorspermine","N(1),N(11)-diethylnorspermine","C059685","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2008,"17920946","Novel anti-apoptotic effect of Bcl-2: prevention of polyamine depletion-induced cell death.","17920946",136]
["N-(2-(2-(2-oxoindolin-3-ylidene)hydrazinecarbonyl)phenyl)-benzamide","N-(2-(2-(2-oxoindolin-3-ylidene)hydrazinecarbonyl)phenyl)-benzamide","C000602698","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25555142","Development of certain novel N-(2-(2-(2-oxoindolin-3-ylidene)hydrazinecarbonyl)phenyl)-benzamides and 3-(2-oxoindolin-3-ylideneamino)-2-substituted quinazolin-4(3H)-ones as CFM-1 analogs: design, synthesis, QSAR analysis and anticancer activity.","25555142",136]
["N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide","N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide","C080955","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2003,"12738747","The cyclooxygenase 2-selective inhibitor NS398 inhibits proliferation of oral carcinoma cell lines by mechanisms dependent and independent of reduced prostaglandin E2 synthesis.","12738747",136]
["N-(2-hydroxypropyl)methacrylamide","N-(2-hydroxypropyl)methacrylamide","C032976","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21599008","Comparison of active and passive targeting of docetaxel for prostate cancer therapy by HPMA copolymer-RGDfK conjugates.","21599008",136]
["N(4)-acetylsulfadimethoxine","N(4)-acetylsulfadimethoxine","C038180","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1990,"2363242","The role of plasma protein binding on the metabolism and renal excretion of sulphadimethoxine and its metabolite N4-acetylsulphadimethoxine in pigs.","2363242",136]
["N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine","N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine","C452423","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23845866","Pretherapeutic drug evaluation by tumor xenografting in anaplastic thyroid cancer.","23845866",136]
["N-(5-(2-(2,2-dimethylpyrrolidin-1-yl)ethylcarbamoyl)-2-methylpyridin-3-yl)-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo(1,5-a)pyridine-3-carboxamide","N-(5-(2-(2,2-dimethylpyrrolidin-1-yl)ethylcarbamoyl)-2-methylpyridin-3-yl)-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo(1,5-a)pyridine-3-carboxamide","C000621123","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2016,"27502700","Optimization of Platelet-Derived Growth Factor Receptor (PDGFR) Inhibitors for Duration of Action, as an Inhaled Therapy for Lung Remodeling in Pulmonary Arterial Hypertension.","27502700",136]
["N-(pyridine-3-ylmethyl)-5-(7-hydroxy-2,6,8-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-yl)-2-methylpenta-2,4-dienamide","N-(pyridine-3-ylmethyl)-5-(7-hydroxy-2,6,8-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-yl)-2-methylpenta-2,4-dienamide","C573938","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23214926","Total synthesis of AMF-26, an antitumor agent for inhibition of the Golgi system, targeting ADP-ribosylation factor 1.","23214926",136]
["N,N'-bis(salicylideneamino)ethane-manganese(II)","N,N'-bis(salicylideneamino)ethane-manganese(II)","C090577","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2013,"23480026","Manganese salen complexes with acid-base catalytic auxiliary: functional mimetics of catalase.","23480026",136]
["N1-(3-(dimethylamino)propyl)-N8-hydroxy-2-((naphthalene-1-loxy)methyl)oct-2-enediamide","N1-(3-(dimethylamino)propyl)-N8-hydroxy-2-((naphthalene-1-loxy)methyl)oct-2-enediamide","C572619","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25781604","Epigenetic modulation with HDAC inhibitor CG200745 induces anti-proliferation in non-small cell lung cancer cells.","25781604",136]
["N-Acetylneuraminic Acid","N-Acetylneuraminic Acid","D019158","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2002,"12486096","Acetylation suppresses the proapoptotic activity of GD3 ganglioside.","12486096",136]
["N-acetylsphingosine","N-acetylsphingosine","C064769","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2002,"11840333","Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA.","11840333",136]
["N-acetylsphingosine","N-acetylsphingosine","C064769","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2002,"12437970","Ceramide induces neuronal apoptosis through the caspase-9/caspase-3 pathway.","12437970",136]
["naftopidil","naftopidil","C064357","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"29098395","Additive naftopidil treatment synergizes docetaxel-induced apoptosis in human prostate cancer cells.","29098395",136]
["Naltrexone","Naltrexone","D009271","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23856908","Targeting the opioid growth factor: opioid growth factor receptor axis for treatment of human ovarian cancer.","23856908",136]
["naphthalene","naphthalene","C031721","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2002,"11818388","Protection of HLE B-3 cells against hydrogen peroxide- and naphthalene-induced lipid peroxidation and apoptosis by transfection with hGSTA1 and hGSTA2.","11818388",136]
["naphthalene","naphthalene","C031721","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2013,"24184422","Concentration-dependent antagonistic persuasion of SDS and naphthalene derivatives on the fibrillation of stem bromelain.","24184422",136]
["Naproxen","Naproxen","D009288","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2016,"26589001","Factors influencing naproxen metabolite interference in total bilirubin assays.","26589001",136]
["naringin","naringin","C005274","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"22940311","Cell surface engineering of α-l-rhamnosidase for naringin hydrolysis.","22940311",136]
["n-butoxyethanol","n-butoxyethanol","C017096","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"26721368","Ethylene glycol ethers induce apoptosis and disturb glucose metabolism in the rat brain.","26721368",136]
["N-caproylsphingosine","N-caproylsphingosine","C101954","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,1998,"10200538","Apoptosis induced by N-hexanoylsphingosine in CHP-100 cells associates with accumulation of endogenous ceramide and is potentiated by inhibition of glucocerebroside synthesis.","10200538",136]
["nedaplatin","nedaplatin","C053989","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"23167374","Intervention effects of nedaplatin and cisplatin on proliferation and apoptosis of human tumour cells in vitro.","23167374",136]
["Nelfinavir","Nelfinavir","D019888","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24483157","The HIV protease inhibitor nelfinavir down-regulates RET signaling and induces apoptosis in medullary thyroid cancer cells.","24483157",136]
["neo-gambogic acid","neo-gambogic acid","C045863","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"25090714","[Gambogenic acid induces mitochondria-dependent apoptosis in human gastric carcinoma cell line].","25090714",136]
["Neostigmine","Neostigmine","D009388","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1994,"7983588","Alkali halide-assisted penetration of neostigmine across excised human skin: a combination of structured water disruption and a Donnan-like effect.","7983588",136]
["Neutral Red","Neutral Red","D009499","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2008,"18835233","A comparison between the responses of neutral red and acridine orange: acridine orange should be preferential and alternative to neutral red as a dye for the monitoring of contaminants by means of biological sensors.","18835233",136]
["Niacin","Niacin","D009525","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1987,"2889727","Kinetic and equilibrium studies on the interaction of reduced flavoprotein D-amino acid oxidase with pyridine carboxylates.","2889727",136]
["Niacinamide","Niacinamide","D009536","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25596087","Nicotinamide induces apoptosis of F9 mouse teratocarcinoma stem cells by downregulation of SATB1 expression.","25596087",136]
["Niacinamide","Niacinamide","D009536","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"26744526","EPHA2 Blockade Overcomes Acquired Resistance to EGFR Kinase Inhibitors in Lung Cancer.","26744526",136]
["Niacinamide","Niacinamide","D009536","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24835786","Synthesis and evaluation of N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)nicotinamides as potential anticancer agents that inhibit tubulin polymerization.","24835786",136]
["Niacinamide","Niacinamide","D009536","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1986,"2946021","Transport of organic cations in brush border membrane vesicles from rabbit kidney cortex.","2946021",136]
["Niacinamide","Niacinamide","D009536","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2002,"12213537","Nicotinamide therapy protects against both necrosis and apoptosis in a stroke model.","12213537",136]
["Nicorandil","Nicorandil","D020108","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"17294816","Insights in the mechanisms underlying the anti-ulcer activity of nicorandil.","17294816",136]
["Nicotine","Nicotine","D009538","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"26856117","Effects of Nicotine on the Submandibular Gland in Rats.","26856117",136]
["Nicotine","Nicotine","D009538","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1965,"14346415","DRUG MOVEMENT FROM THE ISOLATED URINARY BLADDER OF THE RABBIT.","14346415",136]
["Nicotine","Nicotine","D009538","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"17103466","Hydrogen-bond interactions of nicotine and acetylcholine salts: a combined crystallographic, spectroscopic, thermodynamic and theoretical study.","17103466",136]
["Nicotine","Nicotine","D009538","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,2,2012,"22796717","Nicotine and pathological angiogenesis.","22796717",136]
["Nifurtimox","Nifurtimox","D009547","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1990,"2273471","Polarographic study of nifurtimox.","2273471",136]
["nimesulide","nimesulide","C012655","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2005,"16194365","[The effect of selective cyclooxygenase-2 inhibitor nimesulide on breast cancer induced by dimethylbenzoic acid in rats].","16194365",136]
["nimesulide","nimesulide","C012655","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"23112421","Nimesulide inhibits the proliferation of HepG2 by up-regulation of Smad4.","23112421",136]
["N-isopropylacrylamide","N-isopropylacrylamide","C067295","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2006,"16893235","Light-scattering study of polyelectrolyte complex formation between anionic and cationic nanogels in an aqueous salt-free system.","16893235",136]
["Nitric Oxide","Nitric Oxide","D009569","1_MIE",867,1,"Intracellular pH","Decrease","Acid-Base Equilibrium","D000136","Acid-Base Equilibrium",2,3,2004,"15130909","Regulation of regional lung perfusion by nitric oxide.","15130909",136]
["Nitric Oxide","Nitric Oxide","D009569","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,1999,"10336437","The p75(NTR)-induced apoptotic program develops through a ceramide-caspase pathway negatively regulated by nitric oxide.","10336437",136]
["Nitric Oxide","Nitric Oxide","D009569","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2001,"11578809","Killing of lymphoblastic leukemia cells by nitric oxide and taxol: involvement of NF-kappaB activity.","11578809",136]
["Nitric Oxide","Nitric Oxide","D009569","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2003,"12588866","Non-steroidal anti-inflammatory drugs inhibit nitric oxide-induced apoptosis and dedifferentiation of articular chondrocytes independent of cyclooxygenase activity.","12588866",136]
["Nitric Oxide","Nitric Oxide","D009569","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2004,"15572844","[NO-induced apoptosis and ER stress in microglia].","15572844",136]
["Nitric Oxide","Nitric Oxide","D009569","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2005,"15707655","The effect of spermatic vessel ligation on testicular nitric oxide levels and germ cell-specific apoptosis in rat testis.","15707655",136]
["Nitric Oxide","Nitric Oxide","D009569","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2007,"16991100","Nitric oxide, a double edged sword in cancer biology: searching for therapeutic opportunities.","16991100",136]
["Nitric Oxide","Nitric Oxide","D009569","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"19766439","Advanced glycation endproducts increase EPC apoptosis and decrease nitric oxide release via MAPK pathways.","19766439",136]
["Nitric Oxide","Nitric Oxide","D009569","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2013,"23247210","PDT-induced HSP70 externalization up-regulates NO production via TLR2 signal pathway in macrophages.","23247210",136]
["Nitric Oxide","Nitric Oxide","D009569","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2014,"24241898","Part I-mechanism of adaptation: high nitric oxide adapted A549 cells show enhanced DNA damage response and activation of antiapoptotic pathways.","24241898",136]
["Nitric Oxide","Nitric Oxide","D009569","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,1995,"7856740","Chondrocyte apoptosis induced by nitric oxide.","7856740",136]
["Nitric Oxide","Nitric Oxide","D009569","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2005,"15993634","Multiple potassium channels mediate nitric oxide-induced inhibition of rat vascular smooth muscle cell proliferation.","15993634",136]
["Nitric Oxide","Nitric Oxide","D009569","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"20963646","Part II. Initial molecular and cellular characterization of high nitric oxide-adapted human tongue squamous cell carcinoma cell lines.","20963646",136]
["Nitric Oxide","Nitric Oxide","D009569","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21264897","Mechanisms of erythropoiesis inhibition by malarial pigment and malaria-induced proinflammatory mediators in an in vitro model.","21264897",136]
["Nitric Oxide","Nitric Oxide","D009569","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27997616","Structure Elucidation of a Polysaccharide from Umbilicaria esculenta and Its Immunostimulatory Activity.","27997616",136]
["Nitric Oxide","Nitric Oxide","D009569","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2005,"15823089","Role of thiamine thiol form in nitric oxide metabolism.","15823089",136]
["Nitric Oxide","Nitric Oxide","D009569","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2015,"26006011","Convergence of biological nitration and nitrosation via symmetrical nitrous anhydride.","26006011",136]
["Nitric Oxide","Nitric Oxide","D009569","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1995,"8535859","Regional differences in cerebral vasomotor control by nitric oxide.","8535859",136]
["Nitric Oxide","Nitric Oxide","D009569","7_AO",872,7,"Site of Contact Nasal Tumors","Increase","Nasal Cavity","D009296","Nasal Cavity",1,1,2002,"12070204","Ambient oxygen regulates epithelial metabolism and nitric oxide production in the human nose.","12070204",136]
["Nitric Oxide","Nitric Oxide","D009569","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2003,"12962853","Role of nitric oxide in apoptosis and cell necrosis for intestinal transplantation.","12962853",136]
["Nitric Oxide","Nitric Oxide","D009569","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2014,"24259501","NO-independent stimulation or activation of soluble guanylyl cyclase during early reperfusion limits infarct size.","24259501",136]
["Nitric Oxide","Nitric Oxide","D009569","7_AO",872,7,"Site of Contact Nasal Tumors","Increase","Nose","D009666","Nose",1,1,2002,"12070204","Ambient oxygen regulates epithelial metabolism and nitric oxide production in the human nose.","12070204",136]
["nitrobenzene","nitrobenzene","C036077","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2015,"25501538","Organic additives enhance Fenton treatment of nitrobenzene at near-neutral pH.","25501538",136]
["Nitrogen Dioxide","Nitrogen Dioxide","D009585","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Nasal Mucosa","D009297","Nasal Mucosa",1,2,1999,"10226072","Influence of ozone and nitrogen dioxide on histamine and interleukin formation in a human nasal mucosa culture system.","10226072",136]
["Nitroprusside","Nitroprusside","D009599","1_MIE",867,1,"Intracellular pH","Decrease","Acid-Base Equilibrium","D000136","Acid-Base Equilibrium",2,3,1977,"18963","Study of plasma and erythrocyte levels of cyanide ion during perfusion of sodium nitroprusside (Nipride).","18963",136]
["Nitroprusside","Nitroprusside","D009599","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2008,"18458940","H(2)S and HS(-) donor NaHS releases nitric oxide from nitrosothiols, metal nitrosyl complex, brain homogenate and murine L1210 leukaemia cells.","18458940",136]
["Nitrous Oxide","Nitrous Oxide","D009609","1_MIE",867,1,"Intracellular pH","Decrease","Acid-Base Equilibrium","D000136","Acid-Base Equilibrium",2,3,1975,"1172029","[Clinical studies of althesin-nitrous oxide anesthesia in children].","1172029",136]
["Nitrous Oxide","Nitrous Oxide","D009609","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1984,"6424512","Nitrous oxide markedly increases cerebral cortical metabolic rate and blood flow in the goat.","6424512",136]
["N-methyl-5-(4'-pentylphenyl)-2-aminopent-4-ene-1,3-diol","N-methyl-5-(4'-pentylphenyl)-2-aminopent-4-ene-1,3-diol","C544832","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"19723667","Targeting sphingosine kinase 1 inhibits Akt signaling, induces apoptosis, and suppresses growth of human glioblastoma cells and xenografts.","19723667",136]
["N-methylsalsolinium","N-methylsalsolinium","C089303","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1997,"9389601","A neutral N-methyltransferase activity in the striatum determines the level of an endogenous MPP+-like neurotoxin, 1,2-dimethyl-6,7-dihydroxyisoquinolinium ion, in the substantia nigra of human brains.","9389601",136]
["nobiletin","nobiletin","C008661","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27428937","Nobiletin Induces Protective Autophagy Accompanied by ER-Stress Mediated Apoptosis in Human Gastric Cancer SNU-16 Cells.","27428937",136]
["Nonoxynol","Nonoxynol","D017137","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1999,"10715372","Study of the vaginal tolerance to Acidform, an acid-buffering, bioadhesive gel.","10715372",136]
["norbadione A","norbadione A","C464564","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2005,"15669874","Inframolecular protonation process of norbadione A: influence of the ionic environment and stereochemical consequences.","15669874",136]
["Norepinephrine","Norepinephrine","D009638","1_MIE",867,1,"Intracellular pH","Decrease","Acid-Base Equilibrium","D000136","Acid-Base Equilibrium",2,2,1993,"8096498","Determinants of survival after rodent cardiac arrest: implications for therapy with adrenergic agents.","8096498",136]
["Norepinephrine","Norepinephrine","D009638","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1990,"2148186","Spermidine reverses arcaine's inhibition of N-methyl-D-aspartate-induced hippocampal [3H]norepinephrine release.","2148186",136]
["Norepinephrine","Norepinephrine","D009638","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1967,"4291480","Effect of noradrenaline on phosphatase activity in synaptic membrane of the rat brain.","4291480",136]
["Norepinephrine","Norepinephrine","D009638","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1979,"86651","[Determination of the concentration of free and protein-bound adrenaline and noradrenaline in the blood plasma].","86651",136]
["norethindrone acetate","norethindrone acetate","C024262","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2004,"15474755","Apoptosis, proliferation, and sex steroid receptors in postmenopausal endometrium before and during HRT.","15474755",136]
["Norgestrel","Norgestrel","D009644","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2007,"17356463","Ex vivo effect of estrogen and progesterone compared with dexamethasone on cell-mediated immunity of HIV-infected and uninfected subjects.","17356463",136]
["Noxythiolin","Noxythiolin","D009677","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1984,"6425365","Noxythiolin--high-performance liquid chromatographic assay and stability.","6425365",136]
["N-phenyl-7-(hydroxyimino)cyclopropa(b)chromen-1a-carboxamide","N-phenyl-7-(hydroxyimino)cyclopropa(b)chromen-1a-carboxamide","C442478","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28646511","Control of autoimmune inflammation using liposomes to deliver positive allosteric modulators of metabotropic glutamate receptors.","28646511",136]
["N-succinimidyl 3-(2-pyridyldithio)propionate","N-succinimidyl 3-(2-pyridyldithio)propionate","C018151","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24294910","Delivery of chemically glycosylated cytochrome c immobilized in mesoporous silica nanoparticles induces apoptosis in HeLa cancer cells.","24294910",136]
["nutlin 3","nutlin 3","C482205","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2006,"17172851","Concomitant inhibition of MDM2 and Bcl-2 protein function synergistically induce mitochondrial apoptosis in AML.","17172851",136]
["nutlin 3","nutlin 3","C482205","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22780926","[New compound NL-608 (a nutlin analog) induces apoptosis in human breast cancer MCF-7 cells].","22780926",136]
["Nystatin","Nystatin","D009761","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2001,"11557469","Differential antifungal activity of isomeric forms of nystatin.","11557469",136]
["O-(6)-methylguanine","O-(6)-methylguanine","C008449","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,1,1991,"1747377","Kinetics of extension of O6-methylguanine paired with cytosine or thymine in defined oligonucleotide sequences.","1747377",136]
["obacunone glucoside","obacunone glucoside","C411188","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25592883","Cytotoxicity of obacunone and obacunone glucoside in human prostate cancer cells involves Akt-mediated programmed cell death.","25592883",136]
["obatoclax","obatoclax","C520962","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22411899","Obatoclax interacts synergistically with the irreversible proteasome inhibitor carfilzomib in GC- and ABC-DLBCL cells in vitro and in vivo.","22411899",136]
["ochratoxin A","ochratoxin A","C025589","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2005,"16013382","Influence of pH and incubation time on ochratoxin A production by Aspergillus carbonarius in culture media.","16013382",136]
["octadecenyl thiophosphate","octadecenyl thiophosphate","C520653","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2007,"17484878","The lysophosphatidic acid type 2 receptor is required for protection against radiation-induced intestinal injury.","17484878",136]
["Ofloxacin","Ofloxacin","D015242","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2002,"12016015","Separation of levofloxacin, ciprofloxacin, gatifloxacin, moxifloxacin, trovafloxacin and cinoxacin by high-performance liquid chromatography: application to levofloxacin determination in human plasma.","12016015",136]
["Ofloxacin","Ofloxacin","D015242","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2013,"24067633","Development of a spectrofluorimetric method for the determination of ofloxacin in urine.","24067633",136]
["OKN 007","OKN 007","C552724","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"26248280","Inhibition of Pediatric Glioblastoma Tumor Growth by the Anti-Cancer Agent OKN-007 in Orthotopic Mouse Xenografts.","26248280",136]
["Oleanolic Acid","Oleanolic Acid","D009828","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2005,"15863893","Beta-D-xylopyranosyl-(1--&gt;3)-beta-D-glucuronopyranosyl echinocystic acid isolated from the roots of Codonopsis lanceolata induces caspase-dependent apoptosis in human acute promyelocytic leukemia HL-60 cells.","15863893",136]
["Oleanolic Acid","Oleanolic Acid","D009828","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"26639052","CD147 monoclonal antibody mediated by chitosan nanoparticles loaded with α-hederin enhances antineoplastic activity and cellular uptake in liver cancer cells.","26639052",136]
["Oleanolic Acid","Oleanolic Acid","D009828","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Atrophy","D001284","Atrophy",1,1,2016,"25921560","Oleanolic Acid Improves Gut Atrophy Induced by Parenteral Nutrition.","25921560",136]
["Oleic Acid","Oleic Acid","D019301","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"19908022","Peroxisome proliferator-activated receptor alpha (PPARalpha) protects against oleate-induced INS-1E beta cell dysfunction by preserving carbohydrate metabolism.","19908022",136]
["Oleic Acid","Oleic Acid","D019301","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"22189865","Production of 10-hydroxystearic acid from oleic acid and olive oil hydrolyzate by an oleate hydratase from Lysinibacillus fusiformis.","22189865",136]
["oligomycin A","oligomycin A","C031004","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25547679","Tyrosine kinase inhibition in leukemia induces an altered metabolic state sensitive to mitochondrial perturbations.","25547679",136]
["Olive Oil","Olive Oil","D000069463","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21702505","Influence of cultivar and concentration of selected phenolic constituents on the in vitro chemiopreventive potential of olive oil extracts.","21702505",136]
["olvanil","olvanil","C054256","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2004,"15308635","Capsazepine is a novel activator of the delta subunit of the human epithelial Na+ channel.","15308635",136]
["Omeprazole","Omeprazole","D009853","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2003,"12603616","Acid inhibitory potency of twice a day omeprazole is not affected by eradication of Helicobacter pylori in healthy volunteers.","12603616",136]
["Omeprazole","Omeprazole","D009853","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1990,"2130587","Omeprazole in the treatment of patients with severe reflux oesophagitis not responding to H2-receptor antagonists and ineligible for surgery.","2130587",136]
["Omeprazole","Omeprazole","D009853","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1988,"2839196","Specific labelling of gastric H+,K+-ATPase by omeprazole.","2839196",136]
["Omeprazole","Omeprazole","D009853","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1998,"9831269","Speed of onset of oesophageal acid reduction with different proton-pump inhibitors in patients with reflux oesophagitis.","9831269",136]
["Optibond","Optibond","C092987","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2016,"27200432","Morphological Evaluation of the Adhesive/Enamel interfaces of Two-step Self-etching Adhesives and Multimode One-bottle Self-etching Adhesives.","27200432",136]
["orantinib","orantinib","C412603","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2005,"15701856","Pharmacodynamic analysis of target inhibition and endothelial cell death in tumors treated with the vascular endothelial growth factor receptor antagonists SU5416 or SU6668.","15701856",136]
["origanum oil","origanum oil","C029292","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22504090","Assessment of anti-angiogenic and anti-tumoral potentials of Origanum onites L. essential oil.","22504090",136]
["orteronel","orteronel","C571806","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25462236","Synthesis and structure--activity relationship of new cytotoxic agents targeting human glutathione-S-transferases.","25462236",136]
["o-succinylbenzoic acid","o-succinylbenzoic acid","C013691","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1987,"3300553","Biosynthesis of o-succinylbenzoic acid. II: Properties of o-succinylbenzoic acid synthase, an enzyme involved in vitamin K2 biosynthesis.","3300553",136]
["Ouabain","Ouabain","D010042","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2002,"12412103","Efficient synthesis of a tricyclic BCD analogue of ouabain: Lewis acid catalyzed Diels-Alder reactions of sterically hindered systems.","12412103",136]
["Ouabain","Ouabain","D010042","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1975,"235395","Antiarrhythmic activity of four pteridine compounds in ouabain intoxication.","235395",136]
["Oxalic Acid","Oxalic Acid","D019815","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1998,"9518514","In situ characterization of oxalate transport across the basolateral membrane of the proximal tubule.","9518514",136]
["oxaliplatin","oxaliplatin","C030110","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2016,"26799320","Molecular Dissection of Induced Platinum Resistance through Functional and Gene Expression Analysis in a Cell Culture Model of Bladder Cancer.","26799320",136]
["oxaliplatin","oxaliplatin","C030110","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20799994","Anti-tumor effects of CIK combined with oxaliplatin in human oxaliplatin-resistant gastric cancer cells in vivo and in vitro.","20799994",136]
["oxazine 1","oxazine 1","C025904","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2005,"15720749","Absorption and fluorescence spectroscopic study on complexation of Oxazine 1 Dye by calix[8]arenesulfonate.","15720749",136]
["Oxidopamine","Oxidopamine","D016627","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20976472","Effect of 6-hydroxydopamine (6-OHDA) on proliferation of glial cells in the rat cortex and striatum: evidence for de-differentiation of resident astrocytes.","20976472",136]
["oxymatrine","oxymatrine","C037573","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2005,"16499024","[The interference in correlated molecular mechanism obtained multi-drug resistance of mouse S180's tumour cell for different alkaloid].","16499024",136]
["oxymatrine","oxymatrine","C037573","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2007,"17465467","Synergistic effect of oxymatrine and angiogenesis inhibitor NM-3 on modulating apoptosis in human gastric cancer cells.","17465467",136]
["Oxytetracycline","Oxytetracycline","D010118","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Atrophy","D001284","Atrophy",1,1,2016,"27929598","Sclerotic effect of oxytetracycline on the submandibular gland: An experimental model.","27929598",136]
["Ozone","Ozone","D010126","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2001,"11198430","Facilitation of cleaning of alumina surfaces fouled with heat-treated bovine serum albumin by ozone treatment.","11198430",136]
["Ozone","Ozone","D010126","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2009,"19223120","Evaluation of soil pH and moisture content on in-situ ozonation of pyrene in soils.","19223120",136]
["Ozone","Ozone","D010126","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"24873709","Ozonation of diesel-fuel contaminated sand and the implications for remediation end-points.","24873709",136]
["Ozone","Ozone","D010126","7_AO",872,7,"Site of Contact Nasal Tumors","Increase","Nasal Cavity","D009296","Nasal Cavity",1,1,1994,"7896595","Longitudinal distribution of ozone absorption in the lung: comparison of nasal and oral quiet breathing.","7896595",136]
["Paclitaxel","Paclitaxel","D017239","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,1999,"10493958","Activation and the interaction of proapoptotic genes in modulating sensitivity to anticancer drugs in gastric cancer cells.","10493958",136]
["Paclitaxel","Paclitaxel","D017239","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2002,"12168068","The intraductal component of breast cancer is poorly responsive to neo-adjuvant chemotherapy.","12168068",136]
["Paclitaxel","Paclitaxel","D017239","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2003,"14559807","BRCA1 functions as a differential modulator of chemotherapy-induced apoptosis.","14559807",136]
["Paclitaxel","Paclitaxel","D017239","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2008,"18223236","STX140 is efficacious in vitro and in vivo in taxane-resistant breast carcinoma cells.","18223236",136]
["Paclitaxel","Paclitaxel","D017239","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"21518725","B7-H3 silencing increases paclitaxel sensitivity by abrogating Jak2/Stat3 phosphorylation.","21518725",136]
["Paclitaxel","Paclitaxel","D017239","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"24083758","Hypoxia induced multidrug resistance of laryngeal cancer cells via hypoxia-inducible factor-1α.","24083758",136]
["Paclitaxel","Paclitaxel","D017239","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25421492","A novel combined micellar system of lapatinib and Paclitaxel with enhanced antineoplastic effect against human epidermal growth factor receptor-2 positive breast tumor in vitro.","25421492",136]
["Paclitaxel","Paclitaxel","D017239","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2017,"27932243","Inhibition of mTOR/eIF4E by anti-viral drug ribavirin effectively enhances the effects of paclitaxel in oral tongue squamous cell carcinoma.","27932243",136]
["Paclitaxel","Paclitaxel","D017239","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2005,"16310403","Comparison of the relative sensitivity of human lymphocytes and mouse splenocytes to two spindle poisons.","16310403",136]
["Paclitaxel","Paclitaxel","D017239","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2008,"18223236","STX140 is efficacious in vitro and in vivo in taxane-resistant breast carcinoma cells.","18223236",136]
["Paclitaxel","Paclitaxel","D017239","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22754361","Protective effect of caffeic acid on paclitaxel induced anti-proliferation and apoptosis of lung cancer cells involves NF-κB pathway.","22754361",136]
["Paclitaxel","Paclitaxel","D017239","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"26695934","Polymeric Nanomedicine for Combined Gene/Chemotherapy Elicits Enhanced Tumor Suppression.","26695934",136]
["Paclitaxel","Paclitaxel","D017239","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"22053709","Hydrogels as intracellular depots for drug delivery.","22053709",136]
["Paclitaxel","Paclitaxel","D017239","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2016,"26896737","Stepwise pH-responsive nanoparticles containing charge-reversible pullulan-based shells and poly(β-amino ester)/poly(lactic-co-glycolic acid) cores as carriers of anticancer drugs for combination therapy on hepatocellular carcinoma.","26896737",136]
["paeonol","paeonol","C013638","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2013,"23875954","The radiosensitizing effect of Paeonol on lung adenocarcinoma by augmentation of radiation-induced apoptosis and inhibition of the PI3K/Akt pathway.","23875954",136]
["palmidrol","palmidrol","C005958","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22405189","Palmitoylethanolamide exerts neuroprotective effects in mixed neuroglial cultures and organotypic hippocampal slices via peroxisome proliferator-activated receptor-α.","22405189",136]
["Palmitic Acid","Palmitic Acid","D019308","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2012,"23305008","[The unity of pathogenesis of insulin resistance syndrome and non-alcoholic fatty disease of liver. The metabolic disorder of fatty acids and triglycerides].","23305008",136]
["Palmitic Acid","Palmitic Acid","D019308","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,1,1994,"7957923","Palmitoylation but not the extreme amino-terminus of Gq alpha is required for coupling to the NK2 receptor.","7957923",136]
["PAMAM Starburst","PAMAM Starburst","C104700","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2010,"20073071","Alcohol biosensing by polyamidoamine (PAMAM)/cysteamine/alcohol oxidase-modified gold electrode.","20073071",136]
["pamidronate","pamidronate","C019248","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2015,"26285203","The Therapeutic Effect of Pamidronate on Lethal Avian Influenza A H7N9 Virus Infected Humanized Mice.","26285203",136]
["panobinostat","panobinostat","C496932","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23877235","The HDAC inhibitor, panobinostat, induces apoptosis by suppressing the expresssion of specificity protein 1 in oral squamous cell carcinoma.","23877235",136]
["panobinostat","panobinostat","C496932","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22771790","HDACI-induced thrombocytopenia is caused by its unexpected target.","22771790",136]
["Papaverine","Papaverine","D010208","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1977,"24778","The inhibitory effect of papaverine on respiration-dependent contracture of guinea pig taenia coli in high-K medium. I. The relationship between contracture and respiration.","24778",136]
["Paraoxon","Paraoxon","D010261","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,1992,"1509200","Variable involvement of rat skeletal muscles in paraoxon-induced necrotizing myopathy.","1509200",136]
["Paraquat","Paraquat","D010269","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"22265822","CHO cells expressing the human P₅-ATPase ATP13A2 are more sensitive to the toxic effects of herbicide paraquat.","22265822",136]
["paricalcitol","paricalcitol","C084656","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28753620","Treatment combining aliskiren with paricalcitol is effective against progressive renal tubulointerstitial fibrosis via dual blockade of intrarenal renin.","28753620",136]
["parthenolide","parthenolide","C002669","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20590608","Cell context-dependent activities of parthenolide in primary and metastatic melanoma cells.","20590608",136]
["Particulate Matter","Particulate Matter","D052638","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"17940713","Principal physicochemical properties of artificial soil composed of fly ash, sewage sludge and mine tailing.","17940713",136]
["Patulin","Patulin","D010365","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1992,"1539161","Patulin-induced cellular toxicity: a vital fluorescence study.","1539161",136]
["pazopanib","pazopanib","C516667","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23076771","Dynamic analysis of lung metastasis by mouse osteosarcoma LM8: VEGF is a candidate for anti-metastasis therapy.","23076771",136]
["PD 173074","PD 173074","C115711","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"25764758","[FGFR1 selective inhibitor PD173074 can reduce proliferation and induce apoptosis of nasopharyngeal carcinoma].","25764758",136]
["pectin","pectin","C030121","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2006,"16398505","Microstructure and kinetic rheological behavior of amidated and nonamidated LM pectin gels.","16398505",136]
["pectin","pectin","C030121","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2010,"20045114","Comparison of protein-polysaccharide nanoparticle fabrication methods: impact of biopolymer complexation before or after particle formation.","20045114",136]
["pelargonidin","pelargonidin","C066957","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"25184891","Protective effects of common anthocyanidins against genotoxic damage induced by chemotherapeutic drugs in mice.","25184891",136]
["Penicillin G","Penicillin G","D010400","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1982,"6279818","Separation of penicillin and its major degradation products by ion-pair reversed-phase high-pressure liquid chromatography.","6279818",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C243907,B243907)","v":"Pentachlorophenol"},"Pentachlorophenol","D010416","1_MIE",867,1,"Intracellular pH","Decrease",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J243907,K243907)","v":"Hydrogen-Ion Concentration"},"D006863","Hydrogen-Ion Concentration",2,2,2007,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q243907,Q243907)","v":"18290430"},"[Removal of pentachlorophenol catalyzed by immobilized horseradish peroxidase].","18290430",136]
["Pentachlorophenol","Pentachlorophenol","D010416","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2013,"22864755","Pentachlorophenol dechlorination and simultaneous Cr6+ reduction by Pseudomonas putida SKG-1 MTCC (10510): characterization of PCP dechlorination products, bacterial structure, and functional groups.","22864755",136]
["Pentobarbital","Pentobarbital","D010424","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1975,"1245","Differential effects of phenobarbital and pentobarbital on isolated nervous tissue.","1245",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C244355,B244355)","v":"Pentoxifylline"},"Pentoxifylline","D010431","5_KE",768,5,"Cytotoxicity","Increase",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J244355,K244355)","v":"Apoptosis"},"D017209","Apoptosis",1,2,2000,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q244355,Q244355)","v":"10904987"},"New strategy to treat glomerular inflammation by inhibition of mesangial cell matrix metalloproteinases.","10904987",136]
["peoniflorin","peoniflorin","C015423","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28860718","Paeoniflorin suppresses pancreatic cancer cell growth by upregulating HTRA3 expression.","28860718",136]
["PEO-PPO-PEO","PEO-PPO-PEO","C116176","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2011,"21123038","Micelles from PEO-PPO-PEO block copolymers as nanocontainers for solubilization of a poorly water soluble drug hydrochlorothiazide.","21123038",136]
["perfluorooctane sulfonic acid","perfluorooctane sulfonic acid","C076994","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2016,"26378367","Evaluation of single and joint toxicity of perfluorooctane sulfonate and zinc to Limnodrilus hoffmeisteri: Acute toxicity, bioaccumulation and oxidative stress.","26378367",136]
["Pergolide","Pergolide","D010479","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2002,"11755160","Pergolide protects SH-SY5Y cells against neurodegeneration induced by H(2)O(2).","11755160",136]
["perifosine","perifosine","C105905","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2008,"18385752","The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism.","18385752",136]
["Permethrin","Permethrin","D026023","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23612524","Biological significance of the overexpression of HSP70 and alpha B-crystallin in rat substantia nigra exposed to different doses of permethrin.","23612524",136]
["peroxynitric acid","peroxynitric acid","C039642","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1999,"10582617","Peroxynitrite- and nitrite-induced oxidation of dopamine: implications for nitric oxide in dopaminergic cell loss.","10582617",136]
["Peroxynitrous Acid","Peroxynitrous Acid","D030421","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"20708678","Peroxynitrite mediates right-ventricular dysfunction in nitric oxide-exposed juvenile rats.","20708678",136]
["Peroxynitrous Acid","Peroxynitrous Acid","D030421","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2003,"12657855","Deactivation of norepinephrine by peroxynitrite as a new pathogenesis in the hypotension of septic shock.","12657855",136]
["Perylene","Perylene","D010569","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"19922781","A new sol-gel silica nanovehicle preparation for photodynamic therapy in vitro.","19922781",136]
["perylenetetracarboxylic diimide","perylenetetracarboxylic diimide","C517085","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"23093335","The structure and formation of hydrogen-bonded molecular networks on Au(111) surfaces revealed by scanning tunnelling and torsional-tapping atomic force microscopy.","23093335",136]
["Petroleum","Petroleum","D010578","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2010,"20558490","Chest wall necrosis and empyema resulting from attempting suicide by injection of petroleum into the pleural cavity.","20558490",136]
["pevonedistat","pevonedistat","C539933","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28291374","MLN4924 and 2DG combined treatment enhances the efficiency of radiotherapy in breast cancer cells.","28291374",136]
["phenanthrene","phenanthrene","C031181","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"22908628","Effect of corn plant on survival and phenanthrene degradation capacity of Pseudomonas sp. UG14LR in two soils.","22908628",136]
["phenethyl isothiocyanate","phenethyl isothiocyanate","C058305","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,1998,"9458080","Chemopreventive isothiocyanates induce apoptosis and caspase-3-like protease activity.","9458080",136]
["Phenobarbital","Phenobarbital","D010634","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"26351921","Phenobarbital inhibits calpain activity and expression in mouse hepatoma cells.","26351921",136]
["Phenobarbital","Phenobarbital","D010634","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1975,"66","Partial purification and properties of a phenobarbital-induced aldehyde dehydrogenase of rat liver.","66",136]
["Phenol","Phenol","D019800","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1991,"1878207","Accurate determination of pH in organic phenol and phenol:chloroform.","1878207",136]
["phenolic acid","phenolic acid","C017616","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2006,"16488099","Development of a stacking-CZE method for the analysis of phenolic acids.","16488099",136]
["Phenoxybenzamine","Phenoxybenzamine","D010643","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,1970,"4397336","Inhibition by adrenergic blockers of hemorrhagic necrosis in the rat's heart.","4397336",136]
["Phentolamine","Phentolamine","D010646","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1989,"2724447","The pH analysis of papaverine-phentolamine and prostaglandin E1 for pharmacologic erection.","2724447",136]
["Phenylephrine","Phenylephrine","D010656","1_MIE",867,1,"Intracellular pH","Decrease","Acid-Base Equilibrium","D000136","Acid-Base Equilibrium",2,3,2008,"18806043","A randomized double-blinded comparison of phenylephrine and ephedrine infusion combinations to maintain blood pressure during spinal anesthesia for cesarean delivery: the effects on fetal acid-base status and hemodynamic control.","18806043",136]
["Phenylethyl Alcohol","Phenylethyl Alcohol","D010626","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"26122083","Caffeic acid phenethyl ester attenuates ionize radiation-induced intestinal injury through modulation of oxidative stress, apoptosis and p38MAPK in rats.","26122083",136]
["phenylhydrazone","phenylhydrazone","C012483","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2008,"18656670","Anion recognition using newly synthesized hydrogen bonding disubstituted phenylhydrazone-based receptors: poly(vinyl chloride)-based sensor for acetate.","18656670",136]
["phenyl-N-tert-butylnitrone","phenyl-N-tert-butylnitrone","C029217","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2013,"24123007","Cytotoxicity of dihydroartemisinin toward Molt-4 cells attenuated by N-tert-butyl-alpha-phenylnitrone and deferoxamine.","24123007",136]
["Phenylthiohydantoin","Phenylthiohydantoin","D010669","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27330033","Enzalutamide inhibits androgen receptor-positive bladder cancer cell growth.","27330033",136]
["Phenytoin","Phenytoin","D010672","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1980,"7383235","Impaired plasma phenytoin binding in uremia. Effect of in vitro acidification and anion-exchange resin.","7383235",136]
["Phloroglucinol","Phloroglucinol","D010696","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2006,"16424868","Pro-apoptotic properties of hyperforin in leukemic cells from patients with B-cell chronic lymphocytic leukemia.","16424868",136]
["Phloroglucinol","Phloroglucinol","D010696","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27780755","St. John's wort extract and hyperforin inhibit multiple phosphorylation steps of cytokine signaling and prevent inflammatory and apoptotic gene induction in pancreatic β cells.","27780755",136]
["phosphatidylinositol 3,4,5-triphosphate","phosphatidylinositol 3,4,5-triphosphate","C060974","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2005,"15893727","Nucleophosmin/B23, a nuclear PI(3,4,5)P(3) receptor, mediates the antiapoptotic actions of NGF by inhibiting CAD.","15893727",136]
["Phosphoenolpyruvate","Phosphoenolpyruvate","D010728","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1974,"4850232","A mutant of human red cell pyruvate kinase with high affinity for phosphoenolpyruvate.","4850232",136]
["phosphoryl chloride","phosphoryl chloride","C013196","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1995,"7576082","Phosphorylation of beta-lactoglobulin using amino acids as the sole base and nucleophile of the reaction.","7576082",136]
["Phosphorylcholine","Phosphorylcholine","D010767","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"21172010","c-Jun NH2-terminal kinase-dependent upregulation of DR5 mediates cooperative induction of apoptosis by perifosine and TRAIL.","21172010",136]
["Phosphorylcholine","Phosphorylcholine","D010767","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1996,"8960386","Susceptibility of exogenous surfactant to phospholipase A2 degradation.","8960386",136]
["phthalocyanine","phthalocyanine","C013647","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1997,"9450239","Optimum properties of injectable test solutions for intrathecal administration to conscious rats.","9450239",136]
["p-Hydroxyamphetamine","p-Hydroxyamphetamine","D010136","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1997,"9013294","Simple extractive derivatization of methamphetamine and its metabolites in biological materials with Extrelut columns for their GC-MS determination.","9013294",136]
["Phytic Acid","Phytic Acid","D010833","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20127021","Effect of phytic acid and inositol on the proliferation and apoptosis of cells derived from colorectal carcinoma.","20127021",136]
["phytochlorin","phytochlorin","C062985","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2007,"17035716","Induction of apoptosis in HaCaT cells by photodynamic therapy with chlorin e6 or pheophorbide a.","17035716",136]
["PI103","PI103","C522973","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"19528441","Combination of PI3K/mTOR inhibition demonstrates efficacy in human chordoma.","19528441",136]
["picropodophyllin","picropodophyllin","C415032","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2005,"15812560","Insulin-like growth factor-I receptor activity is essential for Kaposi's sarcoma growth and survival.","15812560",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C251331,B251331)","v":"Pilocarpine"},"Pilocarpine","D010862","1_MIE",867,1,"Intracellular pH","Decrease",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J251331,K251331)","v":"Hydrogen-Ion Concentration"},"D006863","Hydrogen-Ion Concentration",2,2,1978,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q251331,Q251331)","v":"26375"},"Influence of pH on the efficacy of pilocarpine.","26375",136]
["pinocembrin","pinocembrin","C016063","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2014,"24395092","Pinocembrin protects SH-SY5Y cells against MPP+-induced neurotoxicity through the mitochondrial apoptotic pathway.","24395092",136]
["pioglitazone","pioglitazone","C060836","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2005,"15916743","Peroxisome proliferator-activated receptor gamma ligands induce cell cycle arrest and apoptosis in human renal carcinoma cell lines.","15916743",136]
["piperacillin, tazobactam drug combination","piperacillin, tazobactam drug combination","C085143","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2014,"24652563","Descending necrotizing mediastinitis: a conservative approach.","24652563",136]
["piperlonguminine","piperlonguminine","C498077","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"26232071","Protection effect of piperine and piperlonguminine from Piper longum L. alkaloids against rotenone-induced neuronal injury.","26232071",136]
["Pirenzepine","Pirenzepine","D010890","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1992,"1376713","Comparative effect of truncal vagotomy and pirenzepine on postprandial secretory response of exocrine pancreas in dogs.","1376713",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C252291,B252291)","v":"pirlimycin"},"pirlimycin","C034093","1_MIE",867,1,"Intracellular pH","Decrease",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J252291,K252291)","v":"Hydrogen-Ion Concentration"},"D006863","Hydrogen-Ion Concentration",2,2,1995,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q252291,Q252291)","v":"8788151"},"Identification and determination of pirlimycin residue in bovine milk and liver by high-performance liquid chromatography-thermospray mass spectrometry.","8788151",136]
["PJ-8 compound","PJ-8 compound","C574189","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22436611","Antiangiogenic mechanisms of PJ-8, a novel inhibitor of vascular endothelial growth factor receptor signaling.","22436611",136]
["plastochromanol 8","plastochromanol 8","C013649","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2013,"23816832","γ-Tocotrienol induced cell cycle arrest and apoptosis via activating the Bax-mediated mitochondrial and AMPK signaling pathways in 3T3-L1 adipocytes.","23816832",136]
["Platelet Activating Factor","Platelet Activating Factor","D010972","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2001,"11270625","Metabolic fate of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine by human spermatozoa: biosynthesis and biodegradation.","11270625",136]
["Platelet Activating Factor","Platelet Activating Factor","D010972","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,1995,"7769733","Effect of pentoxifylline on tissue injury and platelet-activating factor production during ischemia-reperfusion injury.","7769733",136]
["plumbagin","plumbagin","C014758","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2016,"27018383","Plumbagin exerts an immunosuppressive effect on human T-cell acute lymphoblastic leukemia MOLT-4 cells.","27018383",136]
["PMS 777","PMS 777","C507206","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2008,"17712622","PMS777, a bis-interacting ligand for PAF receptor antagonism and AChE inhibition, attenuates PAF-induced neurocytotoxicity in SH-SY5Y cells.","17712622",136]
["Podophyllotoxin","Podophyllotoxin","D011034","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28757065","Design and synthesis of piperazine acetate podophyllotoxin ester derivatives targeting tubulin depolymerization as new anticancer agents.","28757065",136]
["Poloxamer","Poloxamer","D020442","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2007,"17503533","Photo-crosslinkable and biodegradable Pluronic/heparin hydrogels for local and sustained delivery of angiogenic growth factor.","17503533",136]
["Poloxamer","Poloxamer","D020442","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2009,"19432397","PFGSE-NMR study of pH-triggered behavior in pluronic-ibuprofen solutions.","19432397",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C254147,B254147)","v":"poly(2-methacryloyloxyethyl-phosphorylcholine)"},"poly(2-methacryloyloxyethyl-phosphorylcholine)","C115766","1_MIE",867,1,"Intracellular pH","Decrease",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J254147,K254147)","v":"Hydrogen-Ion Concentration"},"D006863","Hydrogen-Ion Concentration",2,2,2005,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q254147,Q254147)","v":"16366531"},"pH-sensitive vesicles based on a biocompatible zwitterionic diblock copolymer.","16366531",136]
["poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)","poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)","C115940","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2005,"15762614","Gelatin blending improves the performance of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) films for biomedical application.","15762614",136]
["poly(4-vinylpyridine)","poly(4-vinylpyridine)","C019535","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"17402706","Quaternized poly(4-vinylpyridine)s as model gene delivery polycations: structure-function study by modification of side chain hydrophobicity and degree of alkylation.","17402706",136]
["poly(epsilon-caprolactone)-b-poly(ethylene glycol)","poly(epsilon-caprolactone)-b-poly(ethylene glycol)","C476300","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27058756","Quercetin and doxorubicin co-encapsulated biotin receptor-targeting nanoparticles for minimizing drug resistance in breast cancer.","27058756",136]
["poly(lactic acid-co-epsilon-caprolactone)","poly(lactic acid-co-epsilon-caprolactone)","C550605","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2015,"26005345","Electrospun nanofibrous SF/P(LLA-CL) membrane: a potential substratum for endothelial keratoplasty.","26005345",136]
["poly(lactide)","poly(lactide)","C033616","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24532258","Liquid perfluorochemical-supported hybrid cell culture system for proliferation of chondrocytes on fibrous polylactide scaffolds.","24532258",136]
["poly(lactide)","poly(lactide)","C033616","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"26838866","Conductive PEDOT:PSS coated polylactide (PLA) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) electrospun membranes: Fabrication and characterization.","26838866",136]
["poly(N-isopropylacrylamide-co-tris-nitrilotriacetic acid acrylamide)","poly(N-isopropylacrylamide-co-tris-nitrilotriacetic acid acrylamide)","C000608164","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2015,"26291123","pH-Triggered Reversible Multiple Protein-Polymer Conjugation Based on Molecular Recognition.","26291123",136]
["poly(styrene-alt-maleic anhydride)","poly(styrene-alt-maleic anhydride)","C520889","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2016,"28008233","Folic acid-conjugated amphiphilic alternating copolymer as a new active tumor targeting drug delivery platform.","28008233",136]
["polyacrylamide gels","polyacrylamide gels","C016680","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2006,"16328246","Synthesis of polyacrylamide gel beads with electrostatic functional groups for the molecular imprinting of bovine serum albumin.","16328246",136]
["polyallylamine","polyallylamine","C063994","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2011,"22103192","Hyaluronic acid immobilization on the poly-allylamine coated nano-network TiO2 surface.","22103192",136]
["polyanions","polyanions","C009791","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1989,"2474460","Regulation of human tyrosine hydroxylase activity. Effects of cyclic AMP-dependent protein kinase, calmodulin-dependent protein kinase II and polyanion.","2474460",136]
["polycaprolactone","polycaprolactone","C016240","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2009,"18431758","Fabrication and characterization of novel nano- and micro-HA/PCL composite scaffolds using a modified rapid prototyping process.","18431758",136]
["polycaprolactone","polycaprolactone","C016240","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20688388","Differences between in vitro viability and differentiation and in vivo bone-forming efficacy of human mesenchymal stem cells cultured on PCL-TCP scaffolds.","20688388",136]
["polycaprolactone","polycaprolactone","C016240","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1992,"1553342","Biodegradable pseudolatexes: the chemical stability of poly(D,L-lactide) and poly(epsilon-caprolactone) nanoparticles in aqueous media.","1553342",136]
["polycarbonate","polycarbonate","C005506","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23601659","Scalable cell alignment on optical media substrates.","23601659",136]
["polydopamine","polydopamine","C568283","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23434693","Improved immobilization of biomolecules to quinone-rich polydopamine for efficient surface functionalization.","23434693",136]
["polydopamine","polydopamine","C568283","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2013,"23904214","Protein resistance and pH-responsive controlled release from the modification of single-walled carbon nanotubes with a double polymer layer.","23904214",136]
["polyethylene glycol-poly(lactic-co-glycolic acid)-polyethylene glycol","polyethylene glycol-poly(lactic-co-glycolic acid)-polyethylene glycol","C520330","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"24457223","In situ gelation of PEG-PLGA-PEG hydrogels containing high loading of hydroxyapatite: in vitro and in vivo characteristics.","24457223",136]
["Polyethyleneimine","Polyethyleneimine","D011094","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"23118717","Antiproliferative activity of fucan nanogel.","23118717",136]
["Polyethyleneimine","Polyethyleneimine","D011094","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"24263409","Thermo-/pH-dual responsive properties of hyperbranched polyethylenimine grafted by phenylalanine.","24263409",136]
["Polyethyleneimine","Polyethyleneimine","D011094","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2016,"27157762","Acid and reduction stimulated logic \"and\"-type combinational release mode achieved in DOX-loaded superparamagnetic nanogel.","27157762",136]
["polyglycerol","polyglycerol","C043941","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25757793","One-pot synthesis of doxorubicin-loaded multiresponsive nanogels based on hyperbranched polyglycerol.","25757793",136]
["Polyglycolic Acid","Polyglycolic Acid","D011100","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2006,"16969757","PCL-PGLA composite tubular scaffold preparation and biocompatibility investigation.","16969757",136]
["Polyglycolic Acid","Polyglycolic Acid","D011100","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2014,"25015608","Comparing supportive properties of poly lactic-co-glycolic acid (PLGA), PLGA/collagen and human amniotic membrane for human urothelial and smooth muscle cells engineering.","25015608",136]
["Polyglycolic Acid","Polyglycolic Acid","D011100","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27383296","Epiregulin-loaded PLGA nanoparticles increase human keratinocytes proliferation: preliminary data.","27383296",136]
["Polyglycolic Acid","Polyglycolic Acid","D011100","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"22095448","Prolonged release from PLGA/HAp scaffolds containing drug-loaded PLGA/gelatin composite microspheres.","22095448",136]
["Polyhydroxyethyl Methacrylate","Polyhydroxyethyl Methacrylate","D011102","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2000,"10903036","Protein A-immobilized microporous polyhydroxyethylmethacrylate affinity membranes for selective sorption of human-immunoglobulin-G from human plasma.","10903036",136]
["polylactic acid-polyglycolic acid copolymer","polylactic acid-polyglycolic acid copolymer","C043435","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2007,"17335016","Surface modification and characterization of chitosan or PLGA membrane with laminin by chemical and oxygen plasma treatment for neural regeneration.","17335016",136]
["polylactic acid-polyglycolic acid copolymer","polylactic acid-polyglycolic acid copolymer","C043435","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2007,"17900737","Sustained delivery of IL-1 Ra from biodegradable microspheres reduces the number of murine B16 melanoma lung metastases.","17900737",136]
["polylactic acid-polyglycolic acid copolymer","polylactic acid-polyglycolic acid copolymer","C043435","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25897850","Controlled delivery of stromal derived factor-1α from poly lactic-co-glycolic acid core-shell particles to recruit mesenchymal stem cells for cardiac regeneration.","25897850",136]
["polylactic acid-polyglycolic acid copolymer","polylactic acid-polyglycolic acid copolymer","C043435","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,3,2013,"23069715","Osteogenesis and angiogenesis induced by porous β-CaSiO(3)/PDLGA composite scaffold via activation of AMPK/ERK1/2 and PI3K/Akt pathways.","23069715",136]
["polymethacrylic acid","polymethacrylic acid","C030613","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"24848786","Internalization of red blood cell-mimicking hydrogel capsules with pH-triggered shape responses.","24848786",136]
["polymethacrylic acid","polymethacrylic acid","C030613","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1993,"7922483","Complexoproductive and antiheparin properties of low density lipoproteins (LDL). III. Interaction of low density lipoproteins (LDL) with synthetic polyanionic compounds.","7922483",136]
["poly-N-isopropylacrylamide","poly-N-isopropylacrylamide","C052970","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2006,"17118883","Preparation and release of model drugs from thermally sensitive poly(N-isopropylacrylamide) based macrospheres.","17118883",136]
["polyphyllin D","polyphyllin D","C121203","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22349056","Polyphyllin D induces apoptosis in human erythrocytes through Ca²⁺ rise and membrane permeabilization.","22349056",136]
["polypropylene glycol","polypropylene glycol","C012504","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1997,"9028052","Increased stability of PEG-PPG conjugated human urokinase against autolysis.","9028052",136]
["polystyrene sulfonic acid","polystyrene sulfonic acid","C003321","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"24410240","Polymer capture by α-hemolysin pore upon salt concentration gradient.","24410240",136]
["Polytetrafluoroethylene","Polytetrafluoroethylene","D011138","7_AO",872,7,"Site of Contact Nasal Tumors","Increase","Nose","D009666","Nose",1,1,1998,"9502843","Management of wide nasofrontal angle with GORE-TEX implants.","9502843",136]
["Polyvinyl Alcohol","Polyvinyl Alcohol","D011142","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2009,"19427099","Characterization of acoustic properties of PVA-shelled ultrasound contrast agents: linear properties (part I).","19427099",136]
["Polyvinyl Alcohol","Polyvinyl Alcohol","D011142","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"22493167","Synthesis and characterization of thermo- and pH-sensitive poly(vinyl alcohol)/poly(N, N-diethylacrylamide-co-itaconic acid) semi-IPN hydrogels.","22493167",136]
["Polyvinyl Chloride","Polyvinyl Chloride","D011143","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2011,"21177026","Poly(vinyl) chloride membrane copper-selective electrode based on 1-phenyl-2-(2-hydroxyphenylhydrazo)butane-1,3-dione.","21177026",136]
["ponceau S","ponceau S","C032756","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1992,"1417905","Ponceau S as a dye for quantitative protein assay. Its use in the presence of Triton X-100.","1417905",136]
["portulacerebroside A","portulacerebroside A","C000611839","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"26823708","Effects of portulacerebroside a on apoptosis of human leukemia HL60 cells and p38/JNK signaling pathway.","26823708",136]
["Potassium Chloride","Potassium Chloride","D011189","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"22809296","The impact of NaCl substitution with KCl on proteinase activities cell-free extract and cell-free supernatant at different pH levels and salt concentrations: Lactobacillus delbrueckii ssp. bulgaricus and Streptococcus thermophilus.","22809296",136]
["Potassium Dichromate","Potassium Dichromate","D011192","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1981,"6112100","Lethal potassium dichromate and whitening (Blankophor) exposure of gold fish (Carassius auratus); chromium levels in gills.","6112100",136]
["Potassium Permanganate","Potassium Permanganate","D011196","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2015,"25965887","Reactivity of β-blockers/agonists with aqueous permanganate. Kinetics and transformation products of salbutamol.","25965887",136]
["Potassium, Dietary","Potassium, Dietary","D017419","1_MIE",867,1,"Intracellular pH","Decrease","Acid-Base Imbalance","D000137","Acid-Base Imbalance",2,2,2009,"19667248","Diet-dependent net acid load and risk of incident hypertension in United States women.","19667248",136]
["Povidone","Povidone","D011205","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2010,"19932676","Partial filling affinity capillary electrophoresis with cationic poly(vinylpyrrolidone)-based copolymer coatings for studies on human lipoprotein-steroid interactions.","19932676",136]
["pralidoxime","pralidoxime","C028797","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1989,"2496095","Effects of soman and its antidotes on tracheal mucociliary transport of ferrets.","2496095",136]
["Prednisolone","Prednisolone","D011239","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2008,"18447956","Legionella pneumophila infection induces programmed cell death, caspase activation, and release of high-mobility group box 1 protein in A549 alveolar epithelial cells: inhibition by methyl prednisolone.","18447956",136]
["Prednisolone","Prednisolone","D011239","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1971,"5108117","Glucocorticoid inhibition of precursor incorporation into nuclear RNA of P1798 lymphosarcoma.","5108117",136]
["prednisolone hemisuccinate","prednisolone hemisuccinate","C021322","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2000,"10959575","Hydrolysis behavior of prednisolone 21-hemisuccinate/beta-cyclodextrin amide conjugate: involvement of intramolecular catalysis of amide group in drug release.","10959575",136]
["pregna-4,17-diene-3,16-dione","pregna-4,17-diene-3,16-dione","C023617","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"19232820","Guggulsterone induces apoptosis in colon cancer cells and inhibits tumor growth in murine colorectal cancer xenografts.","19232820",136]
["pristimerin","pristimerin","C009043","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2012,"22669041","Pristimerin, a triterpenoid, inhibits tumor angiogenesis by targeting VEGFR2 activation.","22669041",136]
["Probenecid","Probenecid","D011339","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Atrophy","D001284","Atrophy",1,1,2012,"22854641","Probenecid prevents acute tubular necrosis in a mouse model of aristolochic acid nephropathy.","22854641",136]
["Procaine","Procaine","D011343","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1985,"2986328","[ATPase activity of the novocaine segregation zones isolated from the erythrocytes of the common frog].","2986328",136]
["procyanidin B2","procyanidin B2","C479580","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27057282","Critical Role of FoxO1 in Granulosa Cell Apoptosis Caused by Oxidative Stress and Protective Effects of Grape Seed Procyanidin B2.","27057282",136]
["Prodigiosin","Prodigiosin","D011353","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"27334973","Targeting survivin with prodigiosin isolated from cell wall of Serratia marcescens induces apoptosis in hepatocellular carcinoma cells.","27334973",136]
["Prometryne","Prometryne","D011400","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1977,"17460","Effects of the herbicides fluometuron and prometryn of Rhizoctonia solani in soil cultures.","17460",136]
["propiconazole","propiconazole","C045950","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2015,"26169906","Determination of acid dissociation constants of triazole fungicides by pressure assisted capillary electrophoresis.","26169906",136]
["Propofol","Propofol","D015742","1_MIE",867,1,"Intracellular pH","Decrease","Acid-Base Equilibrium","D000136","Acid-Base Equilibrium",2,3,1995,"7793188","Intravenous propofol vs thiamylal-isoflurane for caesarean section, comparative maternal and neonatal effects.","7793188",136]
["Propofol","Propofol","D015742","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28035403","Propofol induces proliferation partially via downregulation of p53 protein and promotes migration via activation of the Nrf2 pathway in human breast cancer cell line MDA-MB-231.","28035403",136]
["Propofol","Propofol","D015742","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1994,"8141459","Effects of propofol and thiopental on coronary blood flow and myocardial performance in an isolated rabbit heart.","8141459",136]
["Propranolol","Propranolol","D011433","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2006,"16863686","Statistical optimisation of the mucoadhesivity and characterisation of multipolymeric propranolol matrices for buccal therapy.","16863686",136]
["Propranolol","Propranolol","D011433","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1982,"6182398","Effects of l- and d-propranolol on the ischemic myocardial metabolism of the isolated guniea pig heart, as studied by 31P-NMR.","6182398",136]
["Propylthiouracil","Propylthiouracil","D011441","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,1989,"2484903","Unusual complications of antithyroid drug therapy: four case reports and review of literature.","2484903",136]
["Proscillaridin","Proscillaridin","D011442","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1977,"16755","Stability in vitro of methylproscillaridin.","16755",136]
["Prostaglandin D2","Prostaglandin D2","D015230","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2006,"15979236","PPAR-gamma ligands and amino acid deprivation promote apoptosis of melanoma, prostate, and breast cancer cells.","15979236",136]
["Prostaglandins A","Prostaglandins A","D011454","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,1999,"10381369","Identification of cDNAs for Sox-4, an HMG-Box protein, and a novel human homolog of yeast splicing factor SSF-1 differentially regulated during apoptosis induced by prostaglandin A2/delta12-PGJ2 in Hep3B cells.","10381369",136]
["Prostasan","Prostasan","C571812","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"21656602","Androgen-independent effects of Serenoa repens extract (Prostasan®) on prostatic epithelial cell proliferation and inflammation.","21656602",136]
["protoapigenone","protoapigenone","C524112","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2008,"18430509","Protoapigenone, a novel flavonoid, inhibits ovarian cancer cell growth in vitro and in vivo.","18430509",136]
["protopanaxadiol","protopanaxadiol","C062916","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1993,"8512077","Analysis of ginsenosides by chromatography and mass spectrometry: release of 20 S-protopanaxadiol and 20 S-protopanaxatriol for quantitation.","8512077",136]
["pseudovitamin B12","pseudovitamin B12","C005602","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2009,"20086323","Occurrence of pseudovitamin B12 and its possible function as the cofactor of cobalamin-dependent methionine synthase in a cyanobacterium Synechocystis sp. PCC6803.","20086323",136]
["pterostilbene","pterostilbene","C107773","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"27936461","Pterostilbene protects against myocardial ischemia/reperfusion injury via suppressing oxidative/nitrative stress and inflammatory response.","27936461",136]
["pterostilbene carboxaldehyde thiosemicarbazone","pterostilbene carboxaldehyde thiosemicarbazone","C000610514","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"26850466","Pterostilbene carboxaldehyde thiosemicarbazone, a resveratrol derivative inhibits 17β-Estradiol induced cell migration and proliferation in HUVECs.","26850466",136]
["pullulan","pullulan","C009109","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,1,1993,"7763612","Two-step mutagenesis of Pullularia pullulans leading to clones producing pure pullulan with high yield.","7763612",136]
["Putrescine","Putrescine","D011700","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24827745","Diferuloylputrescine, a predominant phenolic amide in corn bran, potently induces apoptosis in human leukemia U937 cells.","24827745",136]
["Putrescine","Putrescine","D011700","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,1,2009,"19651420","Putrescine N-methyltransferase--the start for alkaloids.","19651420",136]
["pyrazole","pyrazole","C031280","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2005,"15845871","Lipopolysaccharide-induced liver injury in rats treated with the CYP2E1 inducer pyrazole.","15845871",136]
["pyrene","pyrene","C030984","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2013,"24133674","A pyrene-based simple but highly selective fluorescence sensor for Cu(2+) ions via a static excimer mechanism.","24133674",136]
["Pyridoxal","Pyridoxal","D011730","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1983,"6827549","Syntheses of iron bis(pyridoxal isonicotinoylhydrazone)s and the in vivo iron-removal properties of some pyridoxal derivatives.","6827549",136]
["Pyridoxal Phosphate","Pyridoxal Phosphate","D011732","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1971,"5148894","Non-enzymatic transamination between pyridoxal-5-phosphate and kynurenines in the presence of zinc ions.","5148894",136]
["pyridoxal(5')diphospho(1)-glucose","pyridoxal(5')diphospho(1)-glucose","C032401","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1984,"6098301","Does pyridoxal 5'-phosphate function in glycogen phosphorylase as an electrophilic or a general acid catalyst?","6098301",136]
["Pyrimethamine","Pyrimethamine","D011739","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2007,"18392083","Suppression of telomerase activity by pyrimethamine: implication to cancer.","18392083",136]
["Pyrogallol","Pyrogallol","D011748","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2007,"17442475","Pyrogallol, ROS generator inhibits As4.1 juxtaglomerular cells via cell cycle arrest of G2 phase and apoptosis.","17442475",136]
["Pyrogallol","Pyrogallol","D011748","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"22790169","Synthesis and characterization of an organic reagent 4-(6-bromo-2-benzothiazolylazo) pyrogallol and its analytical application.","22790169",136]
["Pyruvaldehyde","Pyruvaldehyde","D011765","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2003,"12938820","Single exposure of mesothelial cells to glucose degradation products (GDPs) yields early advanced glycation end-products (AGEs) and a proinflammatory response.","12938820",136]
["Pyruvaldehyde","Pyruvaldehyde","D011765","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1995,"7848303","Glyoxalase III from Escherichia coli: a single novel enzyme for the conversion of methylglyoxal into D-lactate without reduced glutathione.","7848303",136]
["pyrvinium","pyrvinium","C024631","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"21170416","Pyrvinium, a potent small molecule Wnt inhibitor, promotes wound repair and post-MI cardiac remodeling.","21170416",136]
["Quartz","Quartz","D011791","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2015,"25722107","Effect of the presence of pyrite traces on silver behavior in natural porous media.","25722107",136]
["Quercetin","Quercetin","D011794","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2009,"18971417","Quercetin promotes degradation of survivin and thereby enhances death-receptor-mediated apoptosis in glioma cells.","18971417",136]
["Quercetin","Quercetin","D011794","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24644549","The effect of quercetin on oxidative DNA damage and myelosuppression induced by etoposide in bone marrow cells of rats.","24644549",136]
["Quercetin","Quercetin","D011794","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28524720","Surface-tailored nanomixed micelles containing quercetin-salicylic acid physical complex for enhanced cellular and in vivo activities: a quality by design perspective.","28524720",136]
["Quercetin","Quercetin","D011794","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Atrophy","D001284","Atrophy",1,1,2014,"25614714","Quercetin protects against obesity-induced skeletal muscle inflammation and atrophy.","25614714",136]
["Quercetin","Quercetin","D011794","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"25337190","Quercetin induces morphological and proliferative changes of rat's uteri under estrogen and progesterone influences.","25337190",136]
["Quercetin","Quercetin","D011794","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,1,2011,"21345211","Aglycone specificity of Thermotoga neapolitana β-glucosidase 1A modified by mutagenesis, leading to increased catalytic efficiency in quercetin-3-glucoside hydrolysis.","21345211",136]
["quercetin 3-O-glucopyranoside","quercetin 3-O-glucopyranoside","C110309","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"23000408","Rapid dimerization of quercetin through an oxidative mechanism in the presence of serum albumin decreases its ability to induce cytotoxicity in MDA-MB-231 cells.","23000408",136]
["quinapril","quinapril","C041125","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2008,"18604985","Electrochemical behavior of quinapril and its determination in pharmaceutical formulations by square-wave voltammetry at a mercury electrode.","18604985",136]
["quinoline","quinoline","C037219","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"19966541","Combinational treatment of gap junctional activator and tamoxifen in breast cancer cells.","19966541",136]
["quinone methide","quinone methide","C068040","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2007,"17927245","Chemistry of pyrrolo[1,2-a]indole- and pyrido[1,2-a]indole-based quinone methides. Mechanistic explanations for differences in cytostatic/cytotoxic properties.","17927245",136]
["quisinostat","quisinostat","C541788","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24038993","Initial testing (stage 1) of the histone deacetylase inhibitor, quisinostat (JNJ-26481585), by the Pediatric Preclinical Testing Program.","24038993",136]
["radolmidine","radolmidine","C400294","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2005,"15720782","Fadolmidine-induced ocular hypotension in normotensive rabbits.","15720782",136]
["Ramipril","Ramipril","D017257","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2004,"15229388","Improvement in endothelial progenitor cells from peripheral blood by ramipril therapy in patients with stable coronary artery disease.","15229388",136]
["Ranitidine","Ranitidine","D011899","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1985,"3887977","Pre-operative intramuscular ranitidine and cimetidine. Double blind comparative trial, effect on gastric pH and volume.","3887977",136]
["rasagiline","rasagiline","C031967","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2004,"15247150","Neuroprotection via pro-survival protein kinase C isoforms associated with Bcl-2 family members.","15247150",136]
["Reactive brilliant red X-3B","Reactive brilliant red X-3B","C520101","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"17616239","Interaction of brilliant red X-3B with bovine serum albumin and application to protein assay.","17616239",136]
["Remazol black B","Remazol black B","C063421","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2006,"15967480","Mineralization of Reactive Black 5 in aqueous solution by basic oxygen furnace slag in the presence of hydrogen peroxide.","15967480",136]
["remifentanil","remifentanil","C071741","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"26283875","Effects of Remifentanil Preconditioning on Osteoblasts under Hypoxia-Reoxygenation Condition.","26283875",136]
["Reserpine","Reserpine","D012110","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Nasal Mucosa","D009297","Nasal Mucosa",1,2,1967,"6018199","Reserpine and hypothalamic mediation.","6018199",136]
["resveratrol","resveratrol","C059514","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2005,"15627477","FADD-dependent apoptosis induction in Jurkat leukemia T-cells by the resveratrol analogue, 3,4,5-trihydroxy-trans-stilbene.","15627477",136]
["resveratrol","resveratrol","C059514","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2008,"18688788","Resveratrol induces apoptosis and inhibits adipogenesis in 3T3-L1 adipocytes.","18688788",136]
["resveratrol","resveratrol","C059514","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"21936500","Inhibitory effects of resveratrol and pterostilbene on human colon cancer cells: a side-by-side comparison.","21936500",136]
["resveratrol","resveratrol","C059514","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23353162","[Protective effect of propofol and resveratrol pretreatment against hepatocyte apoptosis in rats with hepatic ischemia-reperfusion injury].","23353162",136]
["resveratrol","resveratrol","C059514","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25862967","The resveratrol oligomers, cis- and trans-gnetin H, from Paeonia suffruticosa seeds inhibit the growth of several human cancer cell lines.","25862967",136]
["resveratrol","resveratrol","C059514","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2004,"15149879","Effects of resveratrol on the expression of a panel of genes interacting with the BRCA1 oncosuppressor in human breast cell lines.","15149879",136]
["resveratrol","resveratrol","C059514","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20595944","[Efficacy study in vitro: assessment of the properties of resveratrol and resveratrol + N-acetyl-cysteine on proliferation and inhibition of collagen activity].","20595944",136]
["resveratrol","resveratrol","C059514","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22574221","Resveratrol inhibits cancer cell metabolism by down regulating pyruvate kinase M2 via inhibition of mammalian target of rapamycin.","22574221",136]
["resveratrol","resveratrol","C059514","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27367854","Resveratrol-Mediated Repression and Reversion of Prostatic Myofibroblast Phenoconversion.","27367854",136]
["resveratrol","resveratrol","C059514","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2017,"28629815","Resveratrol suppresses pulmonary tumor metastasis by inhibiting platelet-mediated angiogenic responses.","28629815",136]
["Retinaldehyde","Retinaldehyde","D012172","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2002,"11960728","All-trans to 13-cis retinal isomerization in light-adapted bacteriorhodopsin at acidic pH.","11960728",136]
["rhamnolipid","rhamnolipid","C418382","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2005,"16398112","Toxic effect of biosurfactant addition on the biodegradation of phenanthrene.","16398112",136]
["Rh-Hr Blood-Group System","Rh-Hr Blood-Group System","D012204","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2010,"20007456","From blood typing to a transport metabolon at a crossroad. Focus on \"Ammonium-dependent sodium uptake in mitochondrion-rich cells of medaka (Oryzias latipes) larvae\".","20007456",136]
["rhodamine B","rhodamine B","C029773","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2009,"19540756","Effectiveness and mechanisms of dye adsorption on a straw-based biochar.","19540756",136]
["rhodioloside","rhodioloside","C009172","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"24189306","Synthesis and neuroprotective effects of the fluorine substituted salidroside analogues in the PC12 cell model exposed to hypoglycemia and serum limitation.","24189306",136]
["Riboflavin","Riboflavin","D012256","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2008,"18498689","Effects of mild heating and acidification on the molecular structure of milk components as investigated by synchronous front-face fluorescence spectroscopy coupled with parallel factor analysis.","18498689",136]
["Riboflavin","Riboflavin","D012256","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,1,1992,"1620102","Riboflavin operon of Bacillus subtilis: unusual symmetric arrangement of the regulatory region.","1620102",136]
["Rifampin","Rifampin","D012293","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2004,"15542335","Preparation and properties of monodispersed rifampicin-loaded poly(lactide-co-glycolide) microspheres.","15542335",136]
["Rifampin","Rifampin","D012293","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,2,2008,"19191541","Isolation of rpoB mutations causing rifampicin resistance in Bacillus subtilis spores exposed to simulated Martian surface conditions.","19191541",136]
["Ringer's lactate","Ringer's lactate","C029239","1_MIE",867,1,"Intracellular pH","Decrease","Acid-Base Equilibrium","D000136","Acid-Base Equilibrium",2,2,1998,"9492494","[Effects of various Ringer's solutions on acid-base balance in rats in hemorrhagic shock and with hepatic dysfunction].","9492494",136]
["ritipenem","ritipenem","C040033","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1989,"2732142","Urinary recovery and tolerability of FCE 22101 following single intravenous administration under restricted and high fluid intake.","2732142",136]
["Rolipram","Rolipram","D020889","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2008,"18455876","Rolipram attenuates acute oligodendrocyte death in the adult rat ventrolateral funiculus following contusive cervical spinal cord injury.","18455876",136]
["Romanowsky-Giemsa stain","Romanowsky-Giemsa stain","C046541","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1987,"2442864","Microwave-stimulated staining of plastic embedded bone marrow sections with the Romanowsky-Giemsa stain: improved staining patterns.","2442864",136]
["roscovitine","roscovitine","C104586","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2005,"16299248","Roscovitine modulates DNA repair and senescence: implications for combination chemotherapy.","16299248",136]
["rosiglitazone","rosiglitazone","C089730","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27416556","Rosiglitazone elevates sensitization of drug-resistant oral epidermoid carcinoma cells to vincristine by G2/M-phase arrest, independent of PPAR-γ pathway.","27416556",136]
["rosmarinic acid","rosmarinic acid","C041376","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28559202","Inhibitory effects of rosmarinic acid on pterygium epithelial cells through redox imbalance and induction of extrinsic and intrinsic apoptosis.","28559202",136]
["Rosuvastatin Calcium","Rosuvastatin Calcium","D000068718","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"26407473","Rosuvastatin ameliorates diabetes-induced reproductive damage via suppression of oxidative stress, inflammatory and apoptotic pathways in male rats.","26407473",136]
["Rotenone","Rotenone","D012402","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2014,"24440618","Flavin-containing monooxygenase, a new clue of pathological proteins in the rotenone model of parkinsonism.","24440618",136]
["Roxithromycin","Roxithromycin","D015575","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Nasal Mucosa","D009297","Nasal Mucosa",1,1,2003,"14679755","[Effect of macrolide antibiotics on VEGF production in nasal mucosa fibroblasts cultured under hypoxic conditions].","14679755",136]
["RRR-alpha-tocopheryloxybutyrate","RRR-alpha-tocopheryloxybutyrate","C519038","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2007,"17187157","Alpha-vitamin E derivative, RRR-alpha-tocopheryloxybutyric acid inhibits the proliferation of prostate cancer cells.","17187157",136]
["rufinamide","rufinamide","C079703","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1995,"7663704","Automated analysis of a novel anti-epileptic compound, CGP 33,101, and its metabolite, CGP 47,292, in body fluids by high-performance liquid chromatography and liquid-solid extraction.","7663704",136]
["S 1 (combination)","S 1 (combination)","C079198","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2011,"21174056","Combined therapy with a thymidylate synthase-inhibiting vector and S-1 has effective antitumor activity against 5-FU-resistant tumors.","21174056",136]
["Saccharin","Saccharin","D012439","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1979,"36123","Response of the rat to saccharin with particular reference to the urinary bladder.","36123",136]
["safingol","safingol","C005682","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2000,"10997964","Characterization of apoptosis induced by protein kinase C inhibitors and its modulation by the caspase pathway in acute promyelocytic leukaemia.","10997964",136]
["Salicylic Acid","Salicylic Acid","D020156","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2005,"16100122","Oxidative stress is responsible for mitochondrial permeability transition induction by salicylate in liver mitochondria.","16100122",136]
["Salicylic Acid","Salicylic Acid","D020156","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2016,"27031802","Study on the kinetics and transformation products of salicylic acid in water via ozonation.","27031802",136]
["salinomycin","salinomycin","C010327","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"23028492","Salinomycin induces autophagy in colon and breast cancer cells with concomitant generation of reactive oxygen species.","23028492",136]
["salinomycin","salinomycin","C010327","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"29107689","Semi-synthetic salinomycin analogs exert cytotoxic activity against human colorectal cancer stem cells.","29107689",136]
["Salvia extract","Salvia extract","C528662","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2016,"26459311","Apoptotic and anti-angiogenic effects of Salvia triloba extract in prostate cancer cell lines.","26459311",136]
["salvin","salvin","C018381","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25510380","Carnosic acid attenuates apoptosis induced by amyloid-β 1-42 or 1-43 in SH-SY5Y human neuroblastoma cells.","25510380",136]
["sanguinarine","sanguinarine","C005705","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2006,"16735106","Sanguinarine overcomes P-glycoprotein-mediated multidrug-resistance via induction of apoptosis and oncosis in CEM-VLB 1000 cells.","16735106",136]
["saponin QA-21V1","saponin QA-21V1","C078785","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1996,"8926578","Isomerization and formulation stability of the vaccine adjuvant QS-21.","8926578",136]
["Sarin","Sarin","D012524","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1992,"1497486","Interaction of obidoxime with sarin in aqueous solution.","1497486",136]
["SB 225002","SB 225002","C112019","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2013,"23359652","SB225002 promotes mitotic catastrophe in chemo-sensitive and -resistant ovarian cancer cells independent of p53 status in vitro.","23359652",136]
["schisandrolic acid","schisandrolic acid","C522399","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2007,"17496413","Cytotoxic activity of schisandrolic and isoschisandrolic acids involves induction of apoptosis.","17496413",136]
["schizandrin B","schizandrin B","C015499","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25756908","Schisandrin B protects PC12 cells against oxidative stress of neurodegenerative diseases.","25756908",136]
["Scotchbond Multi-Purpose","Scotchbond Multi-Purpose","C084018","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1997,"9105146","A short- and long-term shear bond strength study using acids of varying dilutions on bovine dentine.","9105146",136]
["secoisolariciresinol diglucoside","secoisolariciresinol diglucoside","C090142","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2015,"26437389","Ionic Liquid-Based Ultrasonic-Assisted Extraction of Secoisolariciresinol Diglucoside from Flaxseed (Linum usitatissimum L.) with Further Purification by an Aqueous Two-Phase System.","26437389",136]
["selenocyanic acid","selenocyanic acid","C053721","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22982772","Phenylalkyl isoselenocyanates vs phenylalkyl isothiocyanates: thiol reactivity and its implications.","22982772",136]
["Semaxinib","Semaxinib","C116890","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2006,"16860559","Structure-activity-relationship studies of conformationally restricted analogs of combretastatin A-4 derived from SU5416.","16860559",136]
["Sepharose","Sepharose","D012685","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2014,"23635430","Enhancement of in vitro and in vivo function of agarose-encapsulated porcine islets by changes in the islet microenvironment.","23635430",136]
["Serotonin","Serotonin","D012701","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2005,"15736059","Effects of single, double or triple combinations of octreotide, galanin and serotonin on a human pancreatic cancer cell line.","15736059",136]
["Serotonin","Serotonin","D012701","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2004,"15275628","Serotonin and thromboxane A2 stimulate platelet-derived microparticle-induced smooth muscle cell proliferation.","15275628",136]
["Serotonin","Serotonin","D012701","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"26839004","Reducing central serotonin in adulthood promotes hippocampal neurogenesis.","26839004",136]
["Serotonin","Serotonin","D012701","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1973,"4126848","Nicotine and pyrrolidine-induced release of 5-hydroxytryptamine and histamine from neoplastic mast cells.","4126848",136]
["Serotonin","Serotonin","D012701","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,2,1966,"4228174","Humoral conditioning for necrosis. I. The conditioning factors.","4228174",136]
["Sesame Oil","Sesame Oil","D012715","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20814198","Sesame oil accelerates kidney healing following gentamicin-induced kidney injury in rats.","20814198",136]
["sevoflurane","sevoflurane","C009250","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"26973173","Diabetes blocks the cardioprotective effects of sevoflurane postconditioning by impairing Nrf2/Brg1/HO-1 signaling.","26973173",136]
["Sewage","Sewage","D012722","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2002,"12056490","Wastewater sludge as a substrate for growth and carrier for rhizobia: the effect of storage conditions on survival of Sinorhizobium meliloti.","12056490",136]
["Sewage","Sewage","D012722","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2005,"15969293","Formation and biodegradation of toluene in the anaerobic sludge digestion process.","15969293",136]
["Sewage","Sewage","D012722","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"17257833","Assessment of partial nitrification reactor performance through microbial population shift using quinone profile, FISH and SEM.","17257833",136]
["Sewage","Sewage","D012722","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2008,"17980963","Solidification and leaching behaviours of Cr6+ in sludge ceramsite.","17980963",136]
["Sewage","Sewage","D012722","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2010,"20006428","Cr(VI) removal from aqueous solution by dried activated sludge biomass.","20006428",136]
["Sewage","Sewage","D012722","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"22579406","On wet chemical phosphorus recovery from sewage sludge ash by acidic or alkaline leaching and an optimized combination of both.","22579406",136]
["Sewage","Sewage","D012722","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"23240210","Use of organic acids in the composting of municipal solid waste: a pilot-scale study.","23240210",136]
["Sewage","Sewage","D012722","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2015,"25634018","Enhanced dewatering of sludge with the composite of bioflocculant MBFGA1 and P(AM-DMC) as a conditioner.","25634018",136]
["Sewage","Sewage","D012722","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2017,"29145090","Comparative study of dissolved organic matter generated from activated sludge during exposure to hypochlorite, hydrogen peroxide, acid and alkaline: Implications for on-line chemical cleaning of MBR.","29145090",136]
["shenghe","shenghe","C527025","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"22238502","Bidirectional function of shenghe powder on repair of radiation-induced DNA damage in glioma and astrocyte.","22238502",136]
["shikonin","shikonin","C016101","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23261677","Shikonin induces programmed necrosis-like cell death through the formation of receptor interacting protein 1 and 3 complex.","23261677",136]
["shogaol","shogaol","C040115","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"26101062","6-Shogaol induces cell cycle arrest and apoptosis in human hepatoma cells through pleiotropic mechanisms.","26101062",136]
["Sildenafil Citrate","Sildenafil Citrate","D000068677","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"17306493","Liquid chromatography tandem mass spectrometry assay to determine the pharmacokinetics of aildenafil in human plasma.","17306493",136]
["Silica Gel","Silica Gel","D058428","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"22939132","Preparation of a novel dual-function strong cation exchange/hydrophobic interaction chromatography stationary phase for protein separation.","22939132",136]
["Silicic Acid","Silicic Acid","D012824","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1984,"6331217","Magnesium trisilicate mixture BP. Its physical characteristics and effectiveness as a prophylactic.","6331217",136]
["Silicon Dioxide","Silicon Dioxide","D012822","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2005,"15557088","Essential role of p53 in silica-induced apoptosis.","15557088",136]
["Silicon Dioxide","Silicon Dioxide","D012822","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28476966","Biocompatibility assessment of SiO2-TiO2 composite powder on MG63 osteoblast cell lines for orthopaedic applications.","28476966",136]
["Silicon Dioxide","Silicon Dioxide","D012822","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2001,"11258766","Use of vancomycin silica stationary phase in packed capillary electrochromatography I. Enantiomer separation of basic compounds.","11258766",136]
["Silicon Dioxide","Silicon Dioxide","D012822","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"17367176","Preparation and characterization of pure and mixed monolayers of poly(ethylene glycol) brushes chemically adsorbed to silica surfaces.","17367176",136]
["Silicon Dioxide","Silicon Dioxide","D012822","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2009,"19913231","Preparation and characterization of mixed-mode monolithic silica column for capillary electrochromatography.","19913231",136]
["Silicon Dioxide","Silicon Dioxide","D012822","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2011,"21618323","pH-disintegrable polyelectrolyte multilayer-coated mesoporous silica nanoparticles exhibiting triggered co-release of cisplatin and model drug molecules.","21618323",136]
["Silicon Dioxide","Silicon Dioxide","D012822","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"23092612","Adsorption of toxic metal ion Cr(VI) from aqueous state by TiO2-MCM-41: equilibrium and kinetic studies.","23092612",136]
["Silicon Dioxide","Silicon Dioxide","D012822","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"24997914","Chemical behavior of sand alternatives in the marine environment.","24997914",136]
["Silicon Dioxide","Silicon Dioxide","D012822","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2016,"27231265","Bioactivity of Y2O3 and CeO2 doped SiO2-SrO-Na2O glass-ceramics.","27231265",136]
["silver acetate","silver acetate","C103100","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2014,"24726145","Early host tissue response to different types of vascular prostheses coated with silver acetate or vaporized metallic silver.","24726145",136]
["Silver Nitrate","Silver Nitrate","D012835","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1968,"4192618","A silver-impregnation-toluidine blue technique for demonstration of embryonic skeletal structures in paraffin sections.","4192618",136]
["silybin","silybin","C440975","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24528358","Anti-proliferative action of silibinin on human colon adenomatous cancer HT-29 cells.","24528358",136]
["Silymarin","Silymarin","D012838","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22735354","Silibinin, a natural flavonoid, modulates the early expression of chemoprevention             biomarkers in a preclinical model of colon carcinogenesis.","22735354",136]
["simaomicin alpha","simaomicin alpha","C066125","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2009,"19077005","Simaomicin α, a polycyclic xanthone, induces G₁ arrest with suppression of retinoblastoma protein phosphorylation.","19077005",136]
["simendan","simendan","C076731","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2007,"17620456","Antieosinophilic activity of simendans.","17620456",136]
["Simvastatin","Simvastatin","D019821","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"26319048","In vitro and in vivo downregulation of the ATP binding cassette transporter B1 by the HMG-CoA reductase inhibitor simvastatin.","26319048",136]
["Simvastatin","Simvastatin","D019821","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"22876619","Preparation and statistical optimization of alginate based stomach specific floating microcapsules of simvastatin.","22876619",136]
["Singlet Oxygen","Singlet Oxygen","D026082","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,2,2001,"11433036","DNA repair and sequence context affect (1)O(2)-induced mutagenesis in bacteria.","11433036",136]
["sinomenine","sinomenine","C009271","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"17275294","A spectroscopic and molecular modeling study of sinomenine binding to transferrin.","17275294",136]
["Sirolimus","Sirolimus","D020123","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"20935459","Unequal in the absence of death: a novel screen identifies cytotoxic compounds selective for cells with activated Akt.","20935459",136]
["Sirolimus","Sirolimus","D020123","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"24909811","Glucagon-like peptide-1 analog-mediated protection against cholesterol-induced apoptosis via mammalian target of rapamycin activation in pancreatic βTC-6 cells -1mTORβTC-6.","24909811",136]
["Sirolimus","Sirolimus","D020123","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"26375550","Tumor driven by gain-of-function HER2 H878Y mutant is highly sensitive to HER2 inhibitor.","26375550",136]
["Sirolimus","Sirolimus","D020123","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2007,"17700025","Everolimus and mycophenolate mofetil sensitize human pancreatic cancer cells to gemcitabine in vitro: a novel adjunct to standard chemotherapy?","17700025",136]
["Sirolimus","Sirolimus","D020123","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22941374","Everolimus synergizes with gefitinib in non-small-cell lung cancer cell lines resistant to epidermal growth factor receptor tyrosine kinase inhibitors.","22941374",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C289475,B289475)","v":"Sirolimus"},"Sirolimus","D020123","3_KE",870,3,"Cell Proliferation","Increase",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J289475,K289475)","v":"Cell Proliferation"},"D049109","Cell Proliferation",1,2,2016,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q289475,Q289475)","v":"25351606"},"Dysregulation of anergy-related factors involved in regulatory T cells defects in Systemic Lupus Erythematosus patients: Rapamycin and Vitamin D efficacy in restoring regulatory T cells.","25351606",136]
["Sirolimus","Sirolimus","D020123","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25988388","Suppression of the proliferation of hypoxia-Induced retinal pigment epithelial cell by rapamycin through the /mTOR/HIF-1α/VEGF/ signaling.","25988388",136]
["Sitagliptin Phosphate","Sitagliptin Phosphate","D000068900","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"26398375","Immunohistochemical, apoptotic and biochemical changes by dipeptidyl peptidase-4 inhibitor-sitagliptin in type-2 diabetic rats.","26398375",136]
["SKLB1002","SKLB1002","C586326","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2013,"23732650","A new selective vascular endothelial growth factor receptor 2 inhibitor ablates disease in a mouse model of psoriasis.","23732650",136]
["Smoke","Smoke","D012906","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2008,"19139007","Dose-dependent inhibition of tobacco smoke carcinogen-induced lung tumorigenesis in A/J mice by indole-3-carbinol.","19139007",136]
["Smoke","Smoke","D012906","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24467951","Resveratrol mediated cell death in cigarette smoke transformed breast epithelial cells is through induction of p21Waf1/Cip1 and inhibition of long patch base excision repair pathway.","24467951",136]
["Smoke","Smoke","D012906","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,2,2016,"26719146","Cigarette smoke-induced necroptosis and DAMP release trigger neutrophilic airway inflammation in mice.","26719146",136]
["Sodium Acetate","Sodium Acetate","D019346","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1996,"11536740","Growth maintenance of the maize primary root at low water potentials involves increases in cell-wall extension properties, expansin activity, and wall susceptibility to expansins.","11536740",136]
["Sodium Azide","Sodium Azide","D019810","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1999,"10719562","Adsorption of direct-acting and indirect-acting mutagens by various dietary fibers.","10719562",136]
["Sodium Benzoate","Sodium Benzoate","D020160","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2011,"21458638","Determination of sodium benzoate by chiral ligand exchange CE based on its inhibitory activity in D-amino acid oxidase mediated oxidation of D-serine.","21458638",136]
["Sodium Bicarbonate","Sodium Bicarbonate","D017693","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2003,"12649806","[Diabetic ketoacidosis and hyperosmolar hyperglycemia. 24 consecutive cases].","12649806",136]
["Sodium Bicarbonate","Sodium Bicarbonate","D017693","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"24155093","Sodium bicarbonate and high-intensity-cycling capacity: variability in responses.","24155093",136]
["Sodium Bicarbonate","Sodium Bicarbonate","D017693","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,3,1996,"8599788","Effect of pH modification by bicarbonate on pain after subcutaneous lidocaine injection.","8599788",136]
["sodium bichromate","sodium bichromate","C016104","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Olfactory Mucosa","D009831","Olfactory Mucosa",1,2,2014,"24612858","Whole adult organism transcriptional profiling of acute metal exposures in male zebrafish.","24612858",136]
["Sodium Chloride","Sodium Chloride","D012965","1_MIE",867,1,"Intracellular pH","Decrease","Acid-Base Equilibrium","D000136","Acid-Base Equilibrium",2,3,2006,"17130695","Fresh water versus salt water: when will the seas meet!","17130695",136]
["Sodium Chloride","Sodium Chloride","D012965","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2000,"11012869","Increased sodium-proton antiporter activity in patients with obstructive sleep apnoea.","11012869",136]
["Sodium Chloride","Sodium Chloride","D012965","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2002,"12241096","Silica urolithiasis in the dromedary camel in a subtropical climate.","12241096",136]
["Sodium Chloride","Sodium Chloride","D012965","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2006,"16606714","Interaction of brine concentration, brine temperature, and presalting on salt penetration in Ragusano cheese.","16606714",136]
["Sodium Chloride","Sodium Chloride","D012965","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1990,"2118897","The effect of pH, salt concentration and temperature on the survival and growth of Listeria monocytogenes.","2118897",136]
["Sodium Chloride","Sodium Chloride","D012965","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2015,"26177120","Morphological and structural plasticity of grassland species in response to a gradient in saline-sodic soils.","26177120",136]
["Sodium Chloride","Sodium Chloride","D012965","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1979,"42330","Intracranial hemorrhage following intravenous administration of sodium bicarbonate or saline solution in the newborn lamb asphyxiated in utero.","42330",136]
["Sodium Chloride","Sodium Chloride","D012965","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1993,"8346907","Salt-tolerant and thermostable alkaline protease from Bacillus subtilis NCIM no. 64.","8346907",136]
["Sodium Chloride","Sodium Chloride","D012965","7_AO",872,7,"Site of Contact Nasal Tumors","Increase","Nose","D009666","Nose",1,3,2007,"17357049","Inhibition of rhinovirus replication in vitro and in vivo by acid-buffered saline.","17357049",136]
["Sodium Dodecyl Sulfate","Sodium Dodecyl Sulfate","D012967","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2002,"11874114","Design of a new dodecyl sulfate-selective electrode based on conductive polyaniline.","11874114",136]
["Sodium Dodecyl Sulfate","Sodium Dodecyl Sulfate","D012967","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2009,"19764733","pH-Controlled \"off-on-off\" switch based on Cu(2+)-mediated pyrene fluorescence in a PAA-SDS micelle aggregated supramolecular system.","19764733",136]
["Sodium Dodecyl Sulfate","Sodium Dodecyl Sulfate","D012967","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1997,"9218168","DSC studies on bovine serum albumin denaturation. Effects of ionic strength and SDS concentration.","9218168",136]
["Sodium Fluoride","Sodium Fluoride","D012969","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"24401761","A calcium prerinse required to form calcium fluoride in plaque from a sodium fluoride rinse.","24401761",136]
["Sodium Hydroxide","Sodium Hydroxide","D012972","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2011,"21334041","Influence of salt, pH and polyelectrolyte on the pressure electro-dewatering of sewage sludge.","21334041",136]
["Sodium Hypochlorite","Sodium Hypochlorite","D012973","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1971,"4927669","Effect of chlorination in the final washer on bacterial counts of broiler chicken carcasses.","4927669",136]
["sodium metabisulfite","sodium metabisulfite","C005200","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23439480","Ghrelin inhibits sodium metabisulfite induced oxidative stress and apoptosis in rat gastric mucosa.","23439480",136]
["sodium percarbonate","sodium percarbonate","C034738","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1987,"2821711","[The virus-inactivating effect of inorganic peroxy compounds].","2821711",136]
["Sodium Selenite","Sodium Selenite","D018038","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2000,"10964662","Evidence for apoptosis in the selenite rat model of cataract.","10964662",136]
["Sodium Selenite","Sodium Selenite","D018038","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2004,"15190422","Combined effect of sodium selenite and campthotecin on cervical carcinoma cells.","15190422",136]
["sodium sulfate","sodium sulfate","C012036","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1990,"2342129","Effects of sodium sulfate on fecal pH and proliferation of colonic mucosa in patients at high risk for colon cancer.","2342129",136]
["sofalcone","sofalcone","C035032","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1994,"7835618","Effect of sofalcone on tyrosylprotein sulfotransferase.","7835618",136]
["Soil","Soil","D012987","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1992,"1392285","Effect of three newer pesticides on microbial and enzymatic activities in soil.","1392285",136]
["Soil","Soil","D012987","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2004,"15041289","Geochemistry of inorganic arsenic and selenium in a tropical soil: effect of reaction time, pH, and competitive anions on arsenic and selenium adsorption.","15041289",136]
["Soil","Soil","D012987","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2006,"16494861","Detailed sorption isotherms of pentachlorophenol on soils and its correlation with soil properties.","16494861",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C295939,B295939)","v":"Soil"},"Soil","D012987","1_MIE",867,1,"Intracellular pH","Decrease",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J295939,K295939)","v":"Hydrogen-Ion Concentration"},"D006863","Hydrogen-Ion Concentration",2,2,2007,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q295939,Q295939)","v":"17924046"},"Effects of flooding on changes in Eh, pH and speciation of cadmium and lead in contaminated soil.","17924046",136]
["Soil","Soil","D012987","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2008,"18823393","Stoichiometry of soil enzyme activity at global scale.","18823393",136]
["Soil","Soil","D012987","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2008,"19663019","[Acidophilic actinomycetes in various types of soil of Azerbaijan].","19663019",136]
["Soil","Soil","D012987","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2011,"21504539","Decreased N2O reduction by low soil pH causes high N2O emissions in a riparian ecosystem.","21504539",136]
["Soil","Soil","D012987","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"22702821","Past and future seasonal variation in pH and metal concentrations in runoff from river basins on acid sulphate soils in Western Finland.","22702821",136]
["Soil","Soil","D012987","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2013,"23454908","Dictyostelium discoideum developmental cycle (DDDC) assay: a tool for Hg toxicity assessment and soil health screening.","23454908",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C296899,B296899)","v":"Soil"},"Soil","D012987","1_MIE",867,1,"Intracellular pH","Decrease",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J296899,K296899)","v":"Hydrogen-Ion Concentration"},"D006863","Hydrogen-Ion Concentration",2,2,2014,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q296899,Q296899)","v":"25032229"},"Improving phosphorus availability in an acid soil using organic amendments produced from agroindustrial wastes.","25032229",136]
["Soil","Soil","D012987","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2016,"26716572","Three-year study of fast-growing trees in degraded soils amended with composts: Effects on soil fertility and productivity.","26716572",136]
["Soil","Soil","D012987","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2017,"28260653","Extraction and characterization of ternary complexes between natural organic matter, cations, and oxyanions from a natural soil.","28260653",136]
["Soil","Soil","D012987","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1971,"5162916","Collaborative study of a method for the recovery of acid-insoluble residues (soil) in frozen spinach and strawberries.","5162916",136]
["solstitialin A 13-acetate","solstitialin A 13-acetate","C075686","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28591430","Qualitative HPLC-DAD/ESI-TOF-MS Analysis, Cytotoxic, and Apoptotic Effects of Croatian Endemic Centaurea ragusina L. Aqueous Extracts.","28591430",136]
["sorafenib","sorafenib","C471405","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2012,"22176637","Treatment effects of the multikinase inhibitor sorafenib on hepatoblastoma cell lines and xenografts in NMRI-Foxn1 nu mice.","22176637",136]
["sorafenib","sorafenib","C471405","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2007,"17699867","Sorafenib inhibits the imatinib-resistant KITT670I gatekeeper mutation in gastrointestinal stromal tumor.","17699867",136]
["sorafenib","sorafenib","C471405","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"19726678","MicroRNA-122 inhibits tumorigenic properties of hepatocellular carcinoma cells and sensitizes these cells to sorafenib.","19726678",136]
["sorafenib","sorafenib","C471405","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"27085325","Sorafenib effect on liver neoplastic changes in rats: more than a kinase inhibitor.","27085325",136]
["soraprazan","soraprazan","C521310","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,3,2007,"17369284","Soraprazan: setting new standards in inhibition of gastric acid secretion.","17369284",136]
["Sorbitol","Sorbitol","D013012","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1968,"5735973","[Growth of Acetobacter suboxydans on a medium with sorbitol at various values of redox potential].","5735973",136]
["sorbsan","sorbsan","C078112","7_AO",872,7,"Site of Contact Nasal Tumors","Increase","Nose","D009666","Nose",1,1,2012,"21571464","Evaluation of symptoms and QOL with calcium alginate versus chitin-coated gauze for middle meatus packing after endoscopic sinus surgery.","21571464",136]
["Spermidine","Spermidine","D013095","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,1999,"10102555","Polyamines found in the inflamed periodontium inhibit priming and apoptosis in human polymorphonuclear leukocytes.","10102555",136]
["Spermidine","Spermidine","D013095","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1975,"236039","Polyamine activation of staphylococcal nuclease.","236039",136]
["SPES herbal extract","SPES herbal extract","C470612","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2003,"12445678","Pancreatic cancer in vitro toxicity mediated by Chinese herbs SPES and PC-SPES: implications for monotherapy and combination treatment.","12445678",136]
["Sphingosine","Sphingosine","D013110","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2000,"10961348","Ceramides induce apoptosis in HeLa cells and enhance cytochrome c-induced apoptosis in Xenopus egg extracts.","10961348",136]
["Sphingosine","Sphingosine","D013110","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2003,"14560924","Sphingosine-1-phosphate-induced ERK activation protects human melanocytes from UVB-induced apoptosis.","14560924",136]
["Sphingosine","Sphingosine","D013110","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2014,"24722820","Vitamin D therapy in experimental allergic encephalomyelitis could be limited by opposing effects of sphingosine 1-phosphate and gelsolin dysregulation.","24722820",136]
["Sphingosine","Sphingosine","D013110","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,1995,"7658500","Potentiation of apoptosis by treatment with the protein kinase C-specific inhibitor safingol in mitomycin C-treated gastric cancer cells.","7658500",136]
["Sphingosine","Sphingosine","D013110","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27094722","Sphingosine 1-phosphate elicits RhoA-dependent proliferation and MRTF-A mediated gene induction in CPCs.","27094722",136]
["Sphingosine","Sphingosine","D013110","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2007,"17203465","The immunosuppressant FTY720 inhibits tumor angiogenesis via the sphingosine 1-phosphate receptor 1.","17203465",136]
["sphingosine 1-phosphate","sphingosine 1-phosphate","C060506","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2013,"23051607","Phospholipids: \"greasing the wheels\" of humoral immunity.","23051607",136]
["sphingosine 1-phosphate","sphingosine 1-phosphate","C060506","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2015,"25907800","Enterobacteria-secreted particles induce production of exosome-like S1P-containing particles by intestinal epithelium to drive Th17-mediated tumorigenesis.","25907800",136]
["Spiramycin","Spiramycin","D015572","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,1,1992,"1641517","Amplification of a particular DNA sequence in Streptomyces ambofaciens RP181110 reversibly prevents spiramycin production.","1641517",136]
["squaric acid","squaric acid","C030042","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"25036647","Cell uptake and localization studies of squaramide based fluorescent probes.","25036647",136]
["Stainless Steel","Stainless Steel","D013193","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2005,"16283511","Effect of stainless steel manual metal arc welding fume on free radical production, DNA damage, and apoptosis induction.","16283511",136]
["Stainless Steel","Stainless Steel","D013193","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2015,"26410786","The influence of nanostructured features on bacterial adhesion and bone cell functions on severely shot peened 316L stainless steel.","26410786",136]
["Starch","Starch","D013213","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25655498","Photo-crosslinkable biopolymers targeting stem cell adhesion and proliferation: the case study of gelatin and starch-based IPNs.","25655498",136]
["Starch","Starch","D013213","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2008,"18326789","Isolation and characterization of mutants of common ice plant deficient in crassulacean acid metabolism.","18326789",136]
["Starch","Starch","D013213","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2016,"27447598","Characterization and Prebiotic Effect of the Resistant Starch from Purple Sweet Potato.","27447598",136]
["Starch","Starch","D013213","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2017,"28457999","Maltooligosaccharide-forming amylase: Characteristics, preparation, and application.","28457999",136]
["Staurosporine","Staurosporine","D019311","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2002,"11836167","Actions of the selective protein kinase C inhibitor PKC412 on B-chronic lymphocytic leukemia cells in vitro.","11836167",136]
["Staurosporine","Staurosporine","D019311","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22488173","Individual dose and scheduling determine the efficacy of combining cytotoxic anticancer agents with a kinase inhibitor in non-small-cell lung cancer.","22488173",136]
["Steam","Steam","D013227","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2011,"20725804","Dilute acid pretreatment of black spruce using continuous steam explosion system.","20725804",136]
["Steel","Steel","D013232","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2003,"14583204","Contribution of acidic amino residues to the adsorption of peptides onto a stainless steel surface.","14583204",136]
["stevioside","stevioside","C012043","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,3,2011,"21378715","[Sugar of substitute stevioside in chewing gum: comparative double blind controllable study].","21378715",136]
["Streptomycin","Streptomycin","D013307","7_AO",872,7,"Site of Contact Nasal Tumors","Increase","Nose","D009666","Nose",1,1,1964,"14270859","REFRACTORY (STAPHYLOCOCCIC ?) ADENOTONSILLITIS. A BACTERIOLOGIC STUDY.","14270859",136]
["Streptozocin","Streptozocin","D013311","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2008,"18959742","Pituitary adenylate cyclase-activating polypeptide attenuates streptozotocin-induced apoptotic death of RIN-m5F cells through regulation of Bcl-2 family protein mRNA expression.","18959742",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C303427,B303427)","v":"Strychnine"},"Strychnine","D013331","5_KE",768,5,"Cytotoxicity","Increase",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J303427,K303427)","v":"Apoptosis"},"D017209","Apoptosis",1,2,2014,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q303427,Q303427)","v":"24989276"},"[Inducing-apoptosis effect of brucine on human monocytic leukemia cell line THP-1 and its mechanism].","24989276",136]
["styrenesulfonic acid polymer","styrenesulfonic acid polymer","C077114","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2008,"18721835","Release of a model protein from biodegradable self assembled films for surface delivery applications.","18721835",136]
["Succinic Acid","Succinic Acid","D019802","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2015,"25416770","Effects of eliminating pyruvate node pathways and of coexpression of heterogeneous carboxylation enzymes on succinate production by Enterobacter aerogenes.","25416770",136]
["Succinylcholine","Succinylcholine","D013390","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1969,"5391392","Succinylcholine-induced hyperkalemia in burned patients. II.","5391392",136]
["Sucrose","Sucrose","D013395","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2004,"15672232","Production of H2 from sucrose by Escherichia coli strains carrying the pUR400 plasmid, which encodes invertase activity.","15672232",136]
["Sucrose","Sucrose","D013395","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"22173407","The application of surface engineered silica for the treatment of sugar containing wastewater.","22173407",136]
["Sucrose","Sucrose","D013395","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1976,"9430","Capacity of buffers to inhibit acid production within dental plaque.","9430",136]
["sucrose-6-acetate","sucrose-6-acetate","C556997","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2011,"20643232","Study on the synthesis of sucrose-6-acetate catalyzed by fructosyltransferase from Aspergillus oryzae.","20643232",136]
["Sulfamethazine","Sulfamethazine","D013418","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2017,"28802133","Sorptive removal of ionizable antibiotic sulfamethazine from aqueous solution by graphene oxide-coated biochar nanocomposites: Influencing factors and mechanism.","28802133",136]
["Sulfasalazine","Sulfasalazine","D012460","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Atrophy","D001284","Atrophy",1,1,1993,"8094403","Sulfasalazine in atrophie blanche.","8094403",136]
["sulforafan","sulforafan","C016766","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22975350","Sulphoraphane, a naturally occurring isothiocyanate induces apoptosis in breast cancer cells by targeting heat shock proteins.","22975350",136]
["sulforafan","sulforafan","C016766","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24667842","Sulforaphane induces oxidative stress and death by p53-independent mechanism: implication of impaired glutathione recycling.","24667842",136]
["Sulfur Dioxide","Sulfur Dioxide","D013458","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1975,"228","The interaction of SO2 with proteins.","228",136]
["sulfuric acid","sulfuric acid","C033158","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2008,"18039539","The impact of dilute sulfuric acid on the selectivity of xylooligomer depolymerization to monomers.","18039539",136]
["Sulindac","Sulindac","D013467","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2001,"11724286","Induction of apoptosis by sulindac sulfide in HL60 cells is enhanced by p21CiP1 or p27KiP1.","11724286",136]
["Sulindac","Sulindac","D013467","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22653497","Phosphosulindac (OXT-328) selectively targets breast cancer stem cells in vitro and in human breast cancer xenografts.","22653497",136]
["Sulpiride","Sulpiride","D013469","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2000,"10965923","Transcriptional targeting to anterior pituitary lactotrophic cells using recombinant adenovirus vectors in vitro and in vivo in normal and estrogen/sulpiride-induced hyperplastic anterior pituitaries.","10965923",136]
["sunitinib","sunitinib","C473478","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21854714","Are all multi-targeted tyrosine kinase inhibitors created equal? An in vitro study of sunitinib and pazopanib in renal cell carcinoma cell lines.","21854714",136]
["sunitinib","sunitinib","C473478","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"26513662","Prodrug AST-003 Improves the Therapeutic Index of the Multi-Targeted Tyrosine Kinase Inhibitor Sunitinib.","26513662",136]
["superoxidized water","superoxidized water","C118085","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2017,"28224975","Intraperitoneal Infusion of Neutral-pH Superoxidized Solution in Rats: Evaluation of Toxicity and Complications on Peritoneal Surface and Liver.","28224975",136]
["T 0070907","T 0070907","C458508","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"21498701","The PPARgamma antagonist T0070907 suppresses breast cancer cell proliferation and motility via both PPARgamma-dependent and -independent mechanisms.","21498701",136]
["Tacrine","Tacrine","D013619","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2004,"15665397","(+/-)-huprine Y, (-)-huperzine A and tacrine do not show neuroprotective properties in an apoptotic model of neuronal cytoskeletal alteration.","15665397",136]
["Tacrolimus","Tacrolimus","D016559","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"25114905","Therapeutic potential of tacrolimus on acute myocardial infarction in minipigs: analysis with serial cardiac magnetic resonance and changes at histological and protein levels.","25114905",136]
["Tacrolimus","Tacrolimus","D016559","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24912495","Tacrolimus promotes hepatocellular carcinoma and enhances CXCR4/SDF‑1α expression in vivo.","24912495",136]
["TAK 733","TAK 733","C558666","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25376610","Antitumor activity of the MEK inhibitor TAK-733 against melanoma cell lines and patient-derived tumor explants.","25376610",136]
["Tamoxifen","Tamoxifen","D013629","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2003,"12733125","Tamoxifen's apoptotic effect on the endometrium.","12733125",136]
["Tamoxifen","Tamoxifen","D013629","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2005,"16189183","Analogs of GnRH-I and GnRH-II inhibit epidermal growth factor-induced signal transduction and resensitize resistant human breast cancer cells to 4OH-tamoxifen.","16189183",136]
["Tamoxifen","Tamoxifen","D013629","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27163517","Effects of ospemifene, a novel selective estrogen-receptor modulator, on human breast tissue ex vivo.","27163517",136]
["Tamoxifen","Tamoxifen","D013629","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2007,"18058739","Oestradiol and tamoxifen inhibit murine Colon 38 cancer growth and increase the cytotoxic effect of fluorouracil.","18058739",136]
["Tamoxifen","Tamoxifen","D013629","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"24143895","Tranilast enhances the anti-tumor effects of tamoxifen on human breast cancer cells in vitro.","24143895",136]
["Tamoxifen","Tamoxifen","D013629","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"26745050","Cell Cycle Modulation of MCF-7 and MDA-MB-231 by a Sub- Fraction of Strobilanthes crispus and its Combination with Tamoxifen.","26745050",136]
["TAN 1518 A","TAN 1518 A","C088527","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,1994,"8040052","New naphthacenecarboxamide antibiotics, TAN-1518 A and B, have inhibitory activity against mammalian DNA topoisomerase I.","8040052",136]
["tanespimycin","tanespimycin","C112765","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27498942","In vitro study comparing the efficacy of the water-soluble HSP90 inhibitors, 17-AEPGA and 17-DMAG, with that of the non‑water-soluble HSP90 inhibitor, 17-AAG, in breast cancer cell lines.","27498942",136]
["tanshinone","tanshinone","C021751","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28184921","Tanshinone IIA suppresses gastric cancer cell proliferation and migration by downregulation of FOXM1.","28184921",136]
["tanshinone","tanshinone","C021751","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2007,"17344596","[Inhibition of cell growth and induction of apoptosis in human hepatoma cell line HepG2 by tanshione IIA].","17344596",136]
["taspine","taspine","C018394","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2008,"17976967","Taspine isolated from Radix et Rhizoma Leonticis inhibits growth of human umbilical vein endothelial cell (HUVEC) by inducing its apoptosis.","17976967",136]
["Taurine","Taurine","D013654","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2010,"20801504","Roles of TauT and system A in cytoprotection of rat syncytiotrophoblast cell line exposed to hypertonic stress.","20801504",136]
["Taurine","Taurine","D013654","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,1996,"8946648","The beneficial effect of taurine on the prevention of human endothelial cell death.","8946648",136]
["Taurochenodeoxycholic Acid","Taurochenodeoxycholic Acid","D013655","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23149668","Attenuating endoplasmic reticulum stress as a novel therapeutic strategy in pulmonary hypertension.","23149668",136]
["Taurodeoxycholic Acid","Taurodeoxycholic Acid","D013657","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1981,"7215346","360-MHz nuclear magnetic resonance and laser photochemically induced dynamic nuclear polarization studies of bile salt interaction with porcine colipase A.","7215346",136]
["tauroursodeoxycholic acid","tauroursodeoxycholic acid","C031655","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"26759227","Application of Tauroursodeoxycholic Acid for Treatment of Neurological and Non-neurological Diseases: Is There a Potential for Treating Traumatic Brain Injury?","26759227",136]
["tazobactam","tazobactam","C043265","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,2,1994,"7830291","[Mutagenicity tests of tazobactam/piperacillin, tazobactam and piperacillin].","7830291",136]
["Tea","Tea","D013662","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"21776820","Tea polyphenols induce apoptosis through mitochondrial pathway and by inhibiting nuclear factor-kappaB and Akt activation in human cervical cancer cells.","21776820",136]
["Tea","Tea","D013662","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2012,"22045026","Green tea catechin intervention of reactive oxygen species-mediated ERK pathway activation and chronically induced breast cell carcinogenesis.","22045026",136]
["Tea","Tea","D013662","7_AO",872,7,"Site of Contact Nasal Tumors","Increase","Nose","D009666","Nose",1,3,2010,"20884815","Fourteen-week toxicity study of green tea extract in rats and mice.","20884815",136]
["TEC solution","TEC solution","C034627","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Nasal Mucosa","D009297","Nasal Mucosa",1,1,1988,"3337432","Fatality secondary to misuse of TAC solution.","3337432",136]
["technetium tc-99m tetrofosmin","technetium tc-99m tetrofosmin","C078700","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2009,"19726126","Correlation of glioma proliferation assessed by flow cytometry with (99m)Tc-Tetrofosmin SPECT uptake.","19726126",136]
["telenzepine","telenzepine","C046338","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1987,"3694528","Intestinal permeation of nonquaternary amines: a study with telenzepine and pirenzepine in the isolated mucosa of guinea pig jejunum and colon.","3694528",136]
["temozolomide","temozolomide","C047246","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22075712","Downregulation of miR-221/222 sensitizes glioma cells to temozolomide             by regulating apoptosis independently of p53 status.","22075712",136]
["temozolomide","temozolomide","C047246","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24642531","Downregulation of ROCK2 through nanocomplex sensitizes the cytotoxic effect of temozolomide in U251 glioma cells.","24642531",136]
["temozolomide","temozolomide","C047246","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2007,"18006775","AMG 102, a fully human anti-hepatocyte growth factor/scatter factor neutralizing antibody, enhances the efficacy of temozolomide or docetaxel in U-87 MG cells and xenografts.","18006775",136]
["TEMPO","TEMPO","C003959","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2004,"15478099","4-OH-TEMPO prevents the morphological alteration of rat thymocytes primed to apoptosis by oxidative stress inducer ButOOH.","15478099",136]
["Teniposide","Teniposide","D013713","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2008,"18316614","Multidrug resistance-associated protein-overexpressing teniposide-resistant human lymphomas undergo apoptosis by a tubulin-binding agent.","18316614",136]
["tenovin-6","tenovin-6","C574854","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"24512730","The sirtuin inhibitor tenovin-6 upregulates death receptor 5 and enhances cytotoxic effects of 5-fluorouracil and oxaliplatin in colon cancer cells.","24512730",136]
["teriflunomide","teriflunomide","C527525","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"24182769","The effects of teriflunomide on lymphocyte subpopulations in human peripheral blood mononuclear cells in vitro.","24182769",136]
["tertiary-amyl methyl ether","tertiary-amyl methyl ether","C096680","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Olfactory Mucosa","D009831","Olfactory Mucosa",1,1,1997,"9441716","Rat olfactory mucosa displays a high activity in metabolizing methyl tert-butyl ether and other gasoline ethers.","9441716",136]
["Tetracaine","Tetracaine","D013748","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1984,"6335513","Simultaneous determination of chlorhexidine, tetracaine and their degradation products by ion-pair liquid chromatography.","6335513",136]
["tetracalcium phosphate","tetracalcium phosphate","C485830","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2002,"12446185","Calcium phosphate deposition in human dental plaque microcosm biofilms induced by a ureolytic pH-rise procedure.","12446185",136]
["Tetracycline","Tetracycline","D013752","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2009,"19232429","Degradation of tetracycline and oxytetracycline by crude lignin peroxidase prepared from Phanerochaete chrysosporium--a white rot fungus.","19232429",136]
["Tetracycline","Tetracycline","D013752","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1997,"9010992","New approaches to the management and treatment of malignant pericardial effusion.","9010992",136]
["Tetradecanoylphorbol Acetate","Tetradecanoylphorbol Acetate","D013755","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"23041978","Effects of 12-O-tetradecanoylphorbol-13-acetate in combination with             gemcitabine on Panc-1 pancreatic cancer cells cultured in vitro or Panc-1 tumors             grown in immunodeficient mice.","23041978",136]
["Tetradecanoylphorbol Acetate","Tetradecanoylphorbol Acetate","D013755","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"26912086","Regulations of Reversal of Senescence by PKC Isozymes in Response to 12-O-Tetradecanoylphorbol-13-Acetate via Nuclear Translocation of pErk1/2.","26912086",136]
["tetraethoxysilane","tetraethoxysilane","C040733","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2007,"17189618","Vascular endothelial growth factor promotes brain tissue regeneration with a novel biomaterial polydimethylsiloxane-tetraethoxysilane.","17189618",136]
["tetramethyllead","tetramethyllead","C014849","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Atrophy","D001284","Atrophy",1,1,2006,"16717205","Past adult lead exposure is linked to neurodegeneration measured by brain MRI.","16717205",136]
["tetramethylpyrazine","tetramethylpyrazine","C017953","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"25223185","[Ligustrazine fought against cisplatin induced ototoxicity in guinea pigs].","25223185",136]
["tetrandrine","tetrandrine","C009438","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27764754","Tetrandrine protects against oxygen-glucose-serum deprivation/reoxygenation-induced injury via PI3K/AKT/NF-κB signaling pathway in rat spinal cord astrocytes.","27764754",136]
["tetrazolium violet","tetrazolium violet","C531352","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2009,"19407976","Tetrazolium violet induces apoptosis via caspases-8, -9 activation and Fas/FasL up-regulation in rat C6 glioma cells.","19407976",136]
["Thalidomide","Thalidomide","D013792","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"21282741","Increased in vivo efficacy of lenalidomide by addition of piroctone olamine.","21282741",136]
["Thalidomide","Thalidomide","D013792","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25747795","Thalidomide (5HPP-33) suppresses microtubule dynamics and depolymerizes the microtubule network by binding at the vinblastine binding site on tubulin.","25747795",136]
["Thalidomide","Thalidomide","D013792","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2002,"12109812","Thalidomide, an antiangiogenic agent with clinical activity in cancer.","12109812",136]
["Thapsigargin","Thapsigargin","D019284","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2001,"11595736","Thapsigargin and dimethyl sulfoxide activate medium P(i)&lt;--&gt;HOH oxygen exchange catalyzed by sarcoplasmic reticulum Ca2+-ATPase.","11595736",136]
["Theophylline","Theophylline","D013806","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1999,"10701909","Simultaneous assay of ephedrine hydrochloride, theophylline, papaverine hydrochloride and hydroxyzine hydrochloride in tablets using RP-LC.","10701909",136]
["Theophylline","Theophylline","D013806","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2011,"21073321","Investigation of drug release from pellets coated with different shellac types.","21073321",136]
["Theophylline","Theophylline","D013806","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Olfactory Mucosa","D009831","Olfactory Mucosa",1,2,2010,"19727789","Theophylline induces changes in the electro-olfactogram  of the mouse.","19727789",136]
["Thiamine","Thiamine","D013831","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1971,"5094372","[Determination of thiamine hydrochloride].","5094372",136]
["thiazolo(3,2-a)pyrimidine","thiazolo(3,2-a)pyrimidine","C000623116","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28750204","Synthesis and anticancer activity of new thiazolo[3,2-a]pyrimidines: DNA binding and molecular modeling study.","28750204",136]
["thieno(3,2-e)triazolo(4,3-c)pyrimidine","thieno(3,2-e)triazolo(4,3-c)pyrimidine","C000601851","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25499930","Synthesis, anticancer activity and effects on cell cycle profile and apoptosis of novel thieno[2,3-d]pyrimidine and thieno[3,2-e] triazolo[4,3-c]pyrimidine derivatives.","25499930",136]
["thiocolchicoside","thiocolchicoside","C004280","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2016,"24892633","Omega 3 fatty acid-enriched nanoemulsion of thiocolchicoside for transdermal delivery: formulation, characterization and absorption studies.","24892633",136]
["Thioctic Acid","Thioctic Acid","D008063","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1973,"4588680","Glycine metabolism. Lipoic acid as the prosthetic group in the electron transfer protein P2 from Peptococcus glycinophilus.","4588680",136]
["thiocyanate","thiocyanate","C031760","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2017,"28577026","Low temperature, autotrophic microbial denitrification using thiosulfate or thiocyanate as electron donor.","28577026",136]
["Thiopental","Thiopental","D013874","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2008,"18218830","Thiopental protects human T lymphocytes from apoptosis in vitro via the expression of heat shock protein 70.","18218830",136]
["thiosemicarbazide","thiosemicarbazide","C005151","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2016,"27492558","Kinetic and thermodynamic evaluation of adsorption of Cu(II) by thiosemicarbazide chitosan.","27492558",136]
["Thiourea","Thiourea","D013890","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1976,"12069","Effect of metiamide on basal and stimulated serum cholecystokinin levels in duodenal ulcer patients.","12069",136]
["Thromboxane A2","Thromboxane A2","D013928","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1992,"1360630","Correction of ischaemic brain acidosis with SQ29,548/1-benzylimidazole.","1360630",136]
["Thymine","Thymine","D013941","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2006,"16314108","Phosphoramidate and phosphate prodrugs of (-)-beta-D-(2R,4R)-dioxolane-thymine: synthesis, anti-HIV activity and stability studies.","16314108",136]
["thymoquinone","thymoquinone","C003466","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2010,"20594324","Thymoquinone and cisplatin as a therapeutic combination in lung cancer: In vitro and in vivo.","20594324",136]
["thymoquinone","thymoquinone","C003466","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21839059","Polo-box domain inhibitor poloxin activates the spindle assembly checkpoint and inhibits tumor growth in vivo.","21839059",136]
["tibolone","tibolone","C027385","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2006,"17170081","The hormone replacement therapy drug tibolone acts very similar to medroxyprogesterone acetate in an estrogen-and progesterone-responsive endometrial cancer cell line.","17170081",136]
["Timolol","Timolol","D013999","7_AO",872,7,"Site of Contact Nasal Tumors","Increase","Nose Neoplasms","D009669","Nose Neoplasms",1,1,2015,"26010405","Topical timolol in nasal tip hemangioma: a viable alternative to systemic therapy.","26010405",136]
["titanocene","titanocene","C406884","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2007,"17923871","Substituted titanocenes induce caspase-dependent apoptosis in human epidermoid carcinoma cells in vitro and exhibit antitumour activity in vivo.","17923871",136]
["Tobacco Smoke Pollution","Tobacco Smoke Pollution","D014028","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2010,"20739032","Effects of pentoxyfilline and heparin on reperfusion injury island skin flaps in rats exposed to tobacco.","20739032",136]
["Tobramycin","Tobramycin","D014031","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1981,"7271263","[Effect of the inoculum on tobramycin biosynthesis].","7271263",136]
["tolafentrine","tolafentrine","C094030","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"21382892","cAMP phosphodiesterase inhibitors increases nitric oxide production by modulating dimethylarginine dimethylaminohydrolases.","21382892",136]
["Toluene","Toluene","D014050","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2006,"17117137","Pifithrin-alpha attenuates p53-mediated apoptosis and improves cardiac function in response to myocardial ischemia/reperfusion in aged rats.","17117137",136]
["Toluene 2,4-Diisocyanate","Toluene 2,4-Diisocyanate","D014051","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Nasal Mucosa","D009297","Nasal Mucosa",1,1,1986,"3034363","[A case report on death due to an asthmatic attack observed in a guinea pig with TDI-induced asthma].","3034363",136]
["tongxinluo","tongxinluo","C513941","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2016,"26908443","Tongxinluo mitigates atherogenesis by regulating angiogenic factors and inhibiting vasa vasorum neovascularization in apolipoprotein E-deficient mice.","26908443",136]
["torulene","torulene","C078922","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2001,"11571614","beta-Carotene production in sugarcane molasses by a Rhodotorula glutinis mutant.","11571614",136]
["trametinib","trametinib","C560077","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25589619","The BRAF and MEK Inhibitors Dabrafenib and Trametinib: Effects on Immune Function and in Combination with Immunomodulatory Antibodies Targeting PD-1, PD-L1, and CTLA-4.","25589619",136]
["Tranylcypromine","Tranylcypromine","D014191","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28390942","Fluorinated tranylcypromine analogues as inhibitors of lysine-specific demethylase 1 (LSD1, KDM1A).","28390942",136]
["Trehalose","Trehalose","D014199","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"25045743","Protective effects of trehalose on the corneal epithelial cells.","25045743",136]
["tretazicar","tretazicar","C100099","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,1997,"9081711","The expression of bacterial nitroreductase in transgenic mice results in specific cell killing by the prodrug CB1954.","9081711",136]
["Tretinoin","Tretinoin","D014212","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2002,"11896582","Retinoic acid inhibits hepatic Jun N-terminal kinase-dependent signaling pathway in ethanol-fed rats.","11896582",136]
["Tretinoin","Tretinoin","D014212","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2008,"18367633","Effect of 9-cis retinoic acid on dopamine D2 receptor expression in pituitary adenoma cells.","18367633",136]
["Tretinoin","Tretinoin","D014212","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"20303946","Protective effect of all-trans retinoic acid on NMDA-induced neuronal cell death in rat retina.","20303946",136]
["Tretinoin","Tretinoin","D014212","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2016,"27366899","Effect of NADPH-cytochrome P450 reductase on all-trans-retinoic acid efficacy and cytochrome P450 26A1 expression in human myeloid leukaemia HL-60 cells.","27366899",136]
["Tretinoin","Tretinoin","D014212","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,1998,"9627188","Retinoic acid reduces staurosporine-induced apoptotic damage in chick embryonic neurons by suppressing reactive oxygen species production.","9627188",136]
["Tretinoin","Tretinoin","D014212","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2006,"16505366","Retinoic acid is required early during adult neurogenesis in the dentate gyrus.","16505366",136]
["Tretinoin","Tretinoin","D014212","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20935222","Blockade of the ubiquitin protease UBP43 destabilizes transcription factor PML/RARα and inhibits the growth of acute promyelocytic leukemia.","20935222",136]
["Tretinoin","Tretinoin","D014212","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"25164272","β-Carotene during the suckling period is absorbed intact and induces retinoic acid dependent responses similar to preformed vitamin A in intestine and liver, but not adipose tissue of young rats.","25164272",136]
["Tretinoin","Tretinoin","D014212","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,1997,"9815670","In vivo inhibition of angiogenesis and induction of apoptosis by retinoic acid in squamous cell carcinoma.","9815670",136]
["Triacetin","Triacetin","D014215","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"22318766","Cosolvent effects on the drug release and depot swelling in injectable in situ depot-forming systems.","22318766",136]
["Triamcinolone Acetonide","Triamcinolone Acetonide","D014222","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2004,"14977766","Intravitreal triamcinolone with photodynamic therapy for subfoveal choroidal neovascularisation in age related macular degeneration.","14977766",136]
["tributyrin","tributyrin","C005830","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2005,"16277394","Kinetic studies of lycopene isomerization in a tributyrin model system at gastric pH.","16277394",136]
["tricarbonyldichlororuthenium (II) dimer","tricarbonyldichlororuthenium (II) dimer","C447082","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"24066302","Combined treatment of hydroxytyrosol with carbon monoxide-releasing molecule-2 prevents TNF α-induced vascular endothelial cell dysfunction through NO production with subsequent NFκB inactivation.","24066302",136]
["Trichloroacetic Acid","Trichloroacetic Acid","D014238","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2001,"11513421","Photosonochemical degradation of trichloroacetic acid in aqueous solution.","11513421",136]
["trichlorosucrose","trichlorosucrose","C026285","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1996,"8833138","Effect of sucralose in coffee on plaque pH in human subjects.","8833138",136]
["trichostatin A","trichostatin A","C012589","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24665856","The epigenetically regulated effects of Wnt antagonists on the expression of genes in the apoptosis pathway in human bladder cancer cell line (T24).","24665856",136]
["triclocarban","triclocarban","C009540","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24740835","The in vitro estrogenic activities of triclosan and triclocarban.","24740835",136]
["Triclosan","Triclosan","D014260","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27474938","Triclosan activates aryl hydrocarbon receptor (AhR)-dependent apoptosis and affects Cyp1a1 and Cyp1b1 expression in mouse neocortical neurons.","27474938",136]
["Trifluoroacetic Acid","Trifluoroacetic Acid","D014269","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2017,"28371732","Dynamic and thermodynamic mechanisms of TFA adsorption by particulate matter.","28371732",136]
["Trimedoxime","Trimedoxime","D014289","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1999,"9922646","Stability of trimedoxime in concentrated acidic injectable solutions.","9922646",136]
["trimethoxysilane","trimethoxysilane","C071717","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"24407892","Elucidation of selectivity for uranyl ions with an ICT organosilane-modified fluorescent receptor.","24407892",136]
["trimethyloxamine","trimethyloxamine","C005855","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2003,"13129916","Aspolin, a novel extremely aspartic acid-rich protein in fish muscle, promotes iron-mediated demethylation of trimethylamine-N-oxide.","13129916",136]
["triphenylethylene","triphenylethylene","C037749","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24825300","Cytotoxicity and DNA binding property of the dimers of triphenylethylene-coumarin hybrid with one amino side chain.","24825300",136]
["tripterine","tripterine","C050414","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2010,"20007406","Pharmacogenomic approach reveals a role for the x(c)- cystine/glutamate antiporter in growth and celastrol resistance of glioma cell lines.","20007406",136]
["tripterine","tripterine","C050414","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"26474287","Direct inhibition of c-Myc-Max heterodimers by celastrol and celastrol-inspired triterpenoids.","26474287",136]
["triptolide","triptolide","C001899","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2005,"16176806","Triptolide, a diterpenoid triepoxide, induces antitumor proliferation via activation of c-Jun NH2-terminal kinase 1 by decreasing phosphatidylinositol 3-kinase activity in human tumor cells.","16176806",136]
["triptolide","triptolide","C001899","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2013,"23924856","Triptolide induces apoptosis and inhibits the growth and angiogenesis of human pancreatic cancer cells by downregulating COX-2 and VEGF.","23924856",136]
["troglitazone","troglitazone","C057693","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2001,"11298334","The nuclear receptor PPAR gamma is expressed by mouse T lymphocytes and PPAR gamma agonists induce apoptosis.","11298334",136]
["troglitazone","troglitazone","C057693","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2006,"17143939","Effect of ligand troglitazone on peroxisome proliferator-activated receptor gamma expression and cellular growth in human colon cancer cells.","17143939",136]
["Tromethamine","Tromethamine","D014325","1_MIE",867,1,"Intracellular pH","Decrease","Acid-Base Equilibrium","D000136","Acid-Base Equilibrium",2,2,1966,"5906979","[Intravenous perfusions and blood acid-base equilibrium].","5906979",136]
["Tromethamine","Tromethamine","D014325","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1994,"7986387","Cerebral energy metabolism following ESWL brain injury model and effects of cerebral protective drugs.","7986387",136]
["tubeimoside I","tubeimoside I","C051084","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"21687933","Cytotoxicity of tubeimoside I in human choriocarcinoma JEG-3 cells by induction of cytochrome c release and apoptosis via the mitochondrial-related signaling pathway.","21687933",136]
["Tubocurarine","Tubocurarine","D014403","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1972,"5064015","d-Tubocurarine requirements and hypocapnic hyperventilation.","5064015",136]
["Tylosin","Tylosin","D015645","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1991,"1783901","Relationship between threonine dehydratase and biosynthesis of tylosin in Streptomyces fradiae.","1783901",136]
["tyrphostin AGL-2043","tyrphostin AGL-2043","C494191","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2005,"15275819","Locally delivered nanoencapsulated tyrphostin (AGL-2043) reduces neointima formation in balloon-injured rat carotid and stented porcine coronary arteries.","15275819",136]
["Ubiquinone","Ubiquinone","D014451","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2012,"21684136","A novel mechanism of coenzyme Q10 protects against human endothelial cells from oxidative stress-induced injury by modulating NO-related pathways.","21684136",136]
["Ubiquinone","Ubiquinone","D014451","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1992,"1351746","Enzyme inactivation by metal-catalyzed oxidation of coenzyme Q1.","1351746",136]
["ukrain","ukrain","C060921","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"23302993","Ukrain, a plant derived semi-synthetic compound, exerts antitumor effects against murine and human breast cancer and induce protective antitumor immunity in mice.","23302993",136]
["Uracil","Uracil","D014498","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"25118659","1‑calcium phosphate‑uracil, a synthesized pyrimidine derivative agent, has anti‑proliferative, pro‑apoptotic and anti‑invasion effects on multiple tumor cell lines.","25118659",136]
["Uranyl Nitrate","Uranyl Nitrate","D014502","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2010,"20222717","Capturing hydrolysis products in the solid state: effects of pH on uranyl squarates under ambient conditions.","20222717",136]
["Urea","Urea","D014508","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2003,"14560026","Diarylurea compounds inhibit caspase activation by preventing the formation of the active 700-kilodalton apoptosome complex.","14560026",136]
["Urea","Urea","D014508","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25967398","Deficiency in the α1 subunit of Na+/K+-ATPase enhances the anti-proliferative effect of high osmolality in nucleus pulposus intervertebral disc cells.","25967398",136]
["Urea","Urea","D014508","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2004,"15588700","The heme iron coordination of unfolded ferric and ferrous cytochrome c in neutral and acidic urea solutions. Spectroscopic and electrochemical studies.","15588700",136]
["Urea","Urea","D014508","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2010,"19926818","Modulation of urea transport across sheep rumen epithelium in vitro by SCFA and CO2.","19926818",136]
["Urea","Urea","D014508","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2016,"26847584","Label-free and pH-sensitive colorimetric materials for the sensing of urea.","26847584",136]
["Urea","Urea","D014508","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1966,"5903739","The properties of bovine growth hormone. II. Effects of urea.","5903739",136]
["Urethane","Urethane","D014520","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2009,"19401523","Nonsteroidal anti-inflammatory drug-activated gene-1 expression inhibits urethane-induced pulmonary tumorigenesis in transgenic mice.","19401523",136]
["Uric Acid","Uric Acid","D014527","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2004,"15700169","Determination of uric acid in human saliva by capillary electrophoresis with electrochemical detection: potential application in fast diagnosis of gout.","15700169",136]
["Uric Acid","Uric Acid","D014527","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2008,"19043236","A polymer film modified sensor for voltammetric determination of uric acid in the presence of ascorbic Acid and its application in urine.","19043236",136]
["Uric Acid","Uric Acid","D014527","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1969,"5813635","[Permeability measurements for some weak organic acids in the distal convoluted tubule of the rat kidney].","5813635",136]
["Ursodeoxycholic Acid","Ursodeoxycholic Acid","D014580","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,1998,"9637713","A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation.","9637713",136]
["Ursodeoxycholic Acid","Ursodeoxycholic Acid","D014580","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"24312631","Ursodeoxycholic acid but not tauroursodeoxycholic acid inhibits proliferation and differentiation of human subcutaneous adipocytes.","24312631",136]
["ursolic acid","ursolic acid","C005466","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2011,"21910059","Induction of apoptotic cell death by ursolic acid through mitochondrial death pathway and extrinsic death receptor pathway in MDA-MB-231 cells.","21910059",136]
["vadimezan","vadimezan","C066668","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2001,"11280751","Vascular attack by 5,6-dimethylxanthenone-4-acetic acid combined with B7.1 (CD80)-mediated immunotherapy overcomes immune resistance and leads to the eradication of large tumors and multiple tumor foci.","11280751",136]
["Valproic Acid","Valproic Acid","D014635","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22488775","Valproic acid synergistically enhances the cytotoxicity of clofarabine in pediatric acute myeloid leukemia cells.","22488775",136]
["Valproic Acid","Valproic Acid","D014635","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"24083719","Chloroquine and valproic acid combined treatment in vitro has enhanced cytotoxicity in an osteosarcoma cell line.","24083719",136]
["Valproic Acid","Valproic Acid","D014635","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21715447","Application of the histone deacetylase inhibitors for the treatment of endometriosis: histone modifications as pathogenesis and novel therapeutic target.","21715447",136]
["vanadium pentoxide","vanadium pentoxide","C066075","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2006,"17043726","Elucidation of the molecular structure of hydrated vanadium oxide species by X-ray absorption spectroscopy: correlation between the V...V coordination number and distance and the point of zero charge of the support oxide.","17043726",136]
["Vanilmandelic Acid","Vanilmandelic Acid","D014642","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1986,"3955820","Determination of vanillylmandelic acid with ion-pair chromatography and fluorescence detection.","3955820",136]
["vatalanib","vatalanib","C404768","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2009,"19223496","mTOR inhibitor RAD001 (everolimus) has antiangiogenic/vascular properties distinct from a VEGFR tyrosine kinase inhibitor.","19223496",136]
["venetoclax","venetoclax","C579720","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28578655","Potential mechanisms of resistance to venetoclax and strategies to circumvent it.","28578655",136]
["Verapamil","Verapamil","D014700","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,1992,"1421254","[Effects of calcium antagonist finoptin on superoxide dismutase activity and conditioned reflex memory in adrenergic cardiac necroso-genic stress in rats].","1421254",136]
["verteporfin","verteporfin","C098350","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2010,"20066491","Beyond bisphosphonates: photodynamic therapy structurally augments metastatically involved vertebrae and destroys tumor tissue.","20066491",136]
["vesnarinone","vesnarinone","C041667","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,1997,"9328455","Vesnarinone exhibits antitumor effect against myeloid leukemia cells via apoptosis.","9328455",136]
["Vinblastine","Vinblastine","D014747","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20973492","Synthesis and in vitro antitumor effect of vinblastine derivative-oligoarginine conjugates.","20973492",136]
["Vincristine","Vincristine","D014750","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"20191244","Investigation of the proliferation, apoptosis/necrosis, and cell cycle phases in several human multiple myeloma cell lines. Comparison of Viscum album QuFrF extract with vincristine in an in vitro model.","20191244",136]
["Vincristine","Vincristine","D014750","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"17608217","[Preparation of liposome entrapped vincristine sulfate and mitoxantrone chlorhydric acid].","17608217",136]
["vinyl acetate","vinyl acetate","C011566","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1999,"10496674","A biologically based risk assessment for vinyl acetate-induced cancer and noncancer inhalation toxicity.","10496674",136]
["Vitamin A","Vitamin A","D014801","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Atrophy","D001284","Atrophy",1,1,1983,"6601985","Divergent effects of retinoids on pancreatic and liver carcinogenesis in azaserine-treated rats.","6601985",136]
["Vitamin A","Vitamin A","D014801","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1969,"5353595","Hydrolysis of vitamin A acetate by unspecific carboxylesterases from liver and kidney.","5353595",136]
["Vitamin A","Vitamin A","D014801","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,1,1993,"8384721","Disruption of the transthyretin gene results in mice with depressed levels of plasma retinol and thyroid hormone.","8384721",136]
["Vitamin B 12","Vitamin B 12","D014805","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1985,"3976892","Intestinal uptake and release of cobalamin complexed with rat intrinsic factor.","3976892",136]
["Vitamin B 6","Vitamin B 6","D025101","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"26756220","Antitumoral effect of Ocoxin on acute myeloid leukemia.","26756220",136]
["Vitamin D","Vitamin D","D014807","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2006,"16528410","Identification and characterization of noncalcemic, tissue-selective, nonsecosteroidal vitamin D receptor modulators.","16528410",136]
["Vitamin D","Vitamin D","D014807","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2007,"18270398","Vitamin D and cancer.","18270398",136]
["Vitamin D","Vitamin D","D014807","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2010,"20156557","Vitamin D and breast cancer: inhibition of estrogen synthesis and signaling.","20156557",136]
["Vitamin E","Vitamin E","D014810","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22050707","Modulation of microRNA 20b with resveratrol and longevinex is linked with their potent anti-angiogenic action in the ischaemic myocardium and synergestic effects of resveratrol and γ-tocotrienol.","22050707",136]
["Vitamin E","Vitamin E","D014810","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Atrophy","D001284","Atrophy",1,1,1954,"13171168","[The treatment of traumatic testicular atrophy with intratesticular implantation of sex hormones].","13171168",136]
["Vitamin E","Vitamin E","D014810","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2007,"17335992","Vitamin E suppresses telomerase activity in ovarian cancer cells.","17335992",136]
["Vitamin E","Vitamin E","D014810","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2004,"15051643","Antioxidant intervention attenuates myocardial neovascularization in hypercholesterolemia.","15051643",136]
["Vitamin K","Vitamin K","D014812","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1972,"4118102","Mode of action of vitamin K. Calcium binding properties of bovine prothrombin.","4118102",136]
["Vitamin K 3","Vitamin K 3","D024483","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"17658314","The different behaviors of three oxidative mediators in probing the redox activities of the yeast Saccharomyces cerevisiae.","17658314",136]
["vitamin MK 7","vitamin MK 7","C062629","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2005,"15647836","Menaquinone-7 regulates the expressions of osteocalcin, OPG, RANKL and RANK in osteoblastic MC3T3E1 cells.","15647836",136]
["vorinostat","vorinostat","C111237","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2004,"15574791","The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces apoptosis via induction of 15-lipoxygenase-1 in colorectal cancer cells.","15574791",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C335043,B335043)","v":"vorinostat"},"vorinostat","C111237","3_KE",870,3,"Cell Proliferation","Increase",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J335043,K335043)","v":"Cell Proliferation"},"D049109","Cell Proliferation",1,2,2010,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q335043,Q335043)","v":"20679231"},"Histone deacetylase inhibitor induces DNA damage, which normal but not transformed cells can repair.","20679231",136]
["VX680","VX680","C484810","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25592064","Combined treatment with ABT-737 and VX-680 induces apoptosis in Bcl-2- and c-FLIP-overexpressing breast carcinoma cells.","25592064",136]
["Warfarin","Warfarin","D014859","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2003,"12900874","Enantioseparation of warfarin and its metabolites by capillary zone electrophoresis.","12900874",136]
["Warfarin","Warfarin","D014859","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,1994,"8029804","Protein C concentrate in the treatment of warfarin-induced skin necrosis in the protein C deficiency.","8029804",136]
["Waste Water","Waste Water","D062065","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"24667756","Study of the stability of 26 cytostatic drugs and metabolites in wastewater under different conditions.","24667756",136]
["Waste Water","Waste Water","D062065","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"24657758","A soil infiltration system incorporated with sulfur-utilizing autotrophic denitrification (SISSAD) for domestic wastewater treatment.","24657758",136]
["Waste Water","Waste Water","D062065","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2015,"26237683","Production of Biohydrogen from Wastewater by Klebsiella oxytoca ATCC 13182.","26237683",136]
["Water","Water","D014867","1_MIE",867,1,"Intracellular pH","Decrease","Acid-Base Equilibrium","D000136","Acid-Base Equilibrium",2,2,2008,"18203915","Drinking water constituents and disease.","18203915",136]
["Water","Water","D014867","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"25016373","\"On water\" expedient synthesis of 3-indolyl-3-hydroxy oxindole derivatives and their anticancer activity in vitro.","25016373",136]
["Water","Water","D014867","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"26927685","Concise total synthesis of water soluble metatacarboline A, C, D, E and F and its anticancer activity.","26927685",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C336707,B336707)","v":"Water"},"Water","D014867","1_MIE",867,1,"Intracellular pH","Decrease",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J336707,K336707)","v":"Hydrogen-Ion Concentration"},"D006863","Hydrogen-Ion Concentration",2,2,2002,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q336707,Q336707)","v":"12619821"},"Water activity, temperature, and pH effects on growth of the biocontrol agent Pantoea agglomerans CPA-2.","12619821",136]
["Water","Water","D014867","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2004,"14755562","Effect of immobilization support, water activity, and enzyme ionization state on cutinase activity and enantioselectivity in organic media.","14755562",136]
["Water","Water","D014867","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2005,"16097690","[Determination of trace cobalt in water samples by graphite furnace atomic absorption spectrometry after cloud point].","16097690",136]
["Water","Water","D014867","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2006,"16571011","Conformational analysis of XA and AX dipeptides in water by electronic circular dichroism and 1H NMR spectroscopy.","16571011",136]
["Water","Water","D014867","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"17305392","Self-assembly of polypeptide-containing ABC-type triblock copolymers in aqueous solution and its pH dependence.","17305392",136]
["Water","Water","D014867","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2009,"18502574","Application of immobilized nanotubular TiO(2) electrode for photocatalytic hydrogen evolution: reduction of hexavalent chromium (Cr(VI)) in water.","18502574",136]
["Water","Water","D014867","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2009,"19438284","Photo-CIDNP study of transient radicals of Met-Gly and Gly-Met peptides in aqueous solution at variable pH.","19438284",136]
["Water","Water","D014867","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2009,"19746709","Role of interlayer hydration in lincomycin sorption by smectite clays.","19746709",136]
["Water","Water","D014867","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2010,"20417336","Pressurised hot water extraction followed by simultaneous derivatization and headspace solid-phase microextraction and gas chromatography-tandem mass spectrometry for the determination of aliphatic primary amines in sewage sludge.","20417336",136]
["Water","Water","D014867","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2011,"21392969","Removal of arsenic from aqueous solution using pottery granules coated with cyst of Azotobacter and portland cement: characterization, kinetics and modeling.","21392969",136]
["Water","Water","D014867","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2011,"22432287","Seasonal variation effects on the formation of trihalomethane during chlorination of water from Yangtze River and associated cancer risk assessment.","22432287",136]
["Water","Water","D014867","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"22489283","Recyclable fluorescent gold nanocluster membrane for visual sensing of copper(II) ion in aqueous solution.","22489283",136]
["Water","Water","D014867","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2013,"23657984","Effect of glycosylation on the partition behavior of a human antibody in aqueous two-phase systems.","23657984",136]
["Water","Water","D014867","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"24964819","New microprofiling and micro sampling system for water saturated environmental boundary layers.","24964819",136]
["Water","Water","D014867","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2015,"25609387","Evidence for an oxygen evolving iron-oxo-cerium intermediate in iron-catalysed water oxidation.","25609387",136]
["Water","Water","D014867","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2015,"26293145","Smart Fiber Membrane for pH-Induced Oil/Water Separation.","26293145",136]
["Water","Water","D014867","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2017,"28069167","Effect of mobile phase additives on solute retention at low aqueous pH in hydrophilic interaction liquid chromatography.","28069167",136]
["Water","Water","D014867","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1972,"4646280","A study of water and electrolyte transport by the excluded human colon.","4646280",136]
["Water","Water","D014867","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1970,"5443782","Acid-base balance in transition from water breathing to air breathing.","5443782",136]
["Water","Water","D014867","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,1,2010,"20420470","Monomorphic RNA G-quadruplex and polymorphic DNA G-quadruplex structures responding to cellular environmental factors.","20420470",136]
["William's medium E","William's medium E","C475563","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2007,"17181635","Towards the development of a simplified long-term organ culture method for human scalp skin and its appendages under serum-free conditions.","17181635",136]
["withaferin A","withaferin A","C009684","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"22989414","Withaferin A-stimulated Ca2+ entry, ceramide formation and suicidal death of erythrocytes.","22989414",136]
["wogonin","wogonin","C085514","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23955116","Wogonin induces apoptosis by suppressing E6 and E7 expressions and activating intrinsic signaling pathways in HPV-16 cervical cancer cells.","23955116",136]
["WZ4003","WZ4003","C586755","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24171924","Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases.","24171924",136]
["xanthohumol","xanthohumol","C104536","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"26842182","Xanthohumol inhibits cellular proliferation in a breast cancer cell line (MDA-MB231) through an intrinsic mitochondrial-dependent pathway.","26842182",136]
["xanthoxyletin","xanthoxyletin","C477468","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21875271","Xanthoxyletin, a coumarin induces S phase arrest and apoptosis in human gastric adenocarcinoma SGC-7901 cells.","21875271",136]
["Xylazine","Xylazine","D014991","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1992,"1585618","Effects of atipamezole on xylazine sedation in ponies.","1585618",136]
["xylometazoline","xylometazoline","C009695","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Nasal Mucosa","D009297","Nasal Mucosa",1,2,1992,"1360172","Influence of sympathetic and parasympathetic substances in clinical concentrations on human nasal ciliary beat.","1360172",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C341507,B341507)","v":"Xylose"},"Xylose","D014994","1_MIE",867,1,"Intracellular pH","Decrease",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J341507,K341507)","v":"Hydrogen-Ion Concentration"},"D006863","Hydrogen-Ion Concentration",2,2,1995,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q341507,Q341507)","v":"7747962"},"Phosphorus-31 and carbon-13 nuclear magnetic resonance study of glucose and xylose metabolism in agarose-immobilized Candida tropicalis.","7747962",136]
["yangzheng xiaoji","yangzheng xiaoji","C579032","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23828123","Antitumour effects of Yangzheng Xiaoji in human osteosarcoma: the pivotal role of focal adhesion kinase signalling.","23828123",136]
["YK 4-279","YK 4-279","C562345","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28602975","The small molecule inhibitor YK-4-279 disrupts mitotic progression of neuroblastoma cells, overcomes drug resistance and synergizes with inhibitors of mitosis.","28602975",136]
["zampanolide","zampanolide","C444900","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"23136113","Total synthesis of (-)-zampanolide and structure-activity relationship studies on (-)-dactylolide derivatives.","23136113",136]
["Zearalenone","Zearalenone","D015025","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"22326340","Removal of zearalenone toxin from synthetics gastric and body fluids using talc and diatomite: a batch kinetic study.","22326340",136]
["zinc chloride","zinc chloride","C016837","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1991,"1367774","Optimization of growth conditions for the production of proteolytically-sensitive proteins in the periplasmic space of Escherichia coli.","1367774",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C342467,B342467)","v":"zinc hydroxide"},"zinc hydroxide","C052745","1_MIE",867,1,"Intracellular pH","Decrease",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J342467,K342467)","v":"Hydrogen-Ion Concentration"},"D006863","Hydrogen-Ion Concentration",2,2,2017,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q342467,Q342467)","v":"28259079"},"Chemical reactive features of novel amino acids intercalated layered double hydroxides in As(III) and As(V) adsorption.","28259079",136]
["Zinc Oxide","Zinc Oxide","D015034","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2010,"21046990","Photocatalytic degradation of phenol in water using TiO2 and ZnO.","21046990",136]
["Zinc Phosphate Cement","Zinc Phosphate Cement","D015036","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1966,"5216782","Direct pH determinations of setting cements. I. A test method and the effects of storage time and media.","5216782",136]
["Zinc Sulfate","Zinc Sulfate","D019287","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2008,"18353898","Zinc-induced G2/M blockage is p53 and p21 dependent in normal human bronchial epithelial cells.","18353898",136]
["Zinostatin","Zinostatin","D009353","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2005,"15821162","Cold instability of aponeocarzinostatin and its stabilization by labile chromophore.","15821162",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2007,"17903213","Zoledronate has an antitumor effect and induces actin rearrangement in dexamethasone-resistant myeloma cells.","17903213",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22781776","[Study of sequence-dependent in vitro effects of zoledronic acid and paclitaxel upon human nasopharyngeal carcinoma cell line HNE1].","22781776",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22882676","Zoledronic acid in combination with serine/threonine phosphatase inhibitors induces enhanced cytotoxicity and apoptosis in hormone-refractory prostate cancer cell lines by decreasing the activities of PP1 and PP2A.","22882676",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"22996996","Zoledronic acid but not somatostatin analogs exerts anti-tumor effects in a model of murine prostatic neuroendocrine carcinoma of the development of castration-resistant prostate cancer.","22996996",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2012,"23071580","Zoledronate attenuates angiogenic effects of angiotensin II-stimulated endothelial progenitor cells via RhoA and MAPK signaling.","23071580",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23242142","Zoledronic acid significantly enhances radiation‑induced apoptosis against             human fibrosarcoma cells by inhibiting radioadaptive signaling.","23242142",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23245859","In vitro cytotoxicity of zoledronate (nitrogen-containing bisphosphonate: NBP) and/or etidronate (non-NBP) in tumour cells and periodontal cells.","23245859",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23481325","Mechanisms of the antitumor activity of human Vγ9Vδ2 T cells in combination with zoledronic acid in a preclinical model of neuroblastoma.","23481325",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23725755","STAT pathway in the regulation of zoledronic acid-induced apoptosis in chronic myeloid leukemia cells.","23725755",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23741352","Zoledronic acid sensitizes renal cell carcinoma cells to radiation by downregulating STAT1.","23741352",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23807419","Bisphosphonates modulate vital functions of human osteoblasts and affect their interactions with breast cancer cells.","23807419",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"23874464","Zoledronic acid enhances lipopolysaccharide-stimulated proinflammatory reactions through controlled expression of SOCS1 in macrophages.","23874464",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"24060052","Comparison of the anti-tumor effects of denosumab and zoledronic acid on the neoplastic stromal cells of giant cell tumor of bone.","24060052",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"24157872","Panobinostat synergizes with zoledronic acid in prostate cancer and multiple myeloma models by increasing ROS and modulating mevalonate and p38-MAPK pathways.","24157872",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"24177992","Macrophages as potential targets for zoledronic acid outside the skeleton-evidence from in vitro and in vivo models.","24177992",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"24324070","Lung cancer cell line sensitivity to Zoledronic acid is BAX-dependent.","24324070",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2014,"24422540","Effect of bisphosphonates on the rapidly growing male murine skeleton.","24422540",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"24509224","Protective effect of zoledronic acid on corticosteroid-induced chondrocyte apoptosis in rat articular cartilage.","24509224",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2014,"24573639","Zoledronic acid treatment in advanced non-small cell lung cancer patients with bone metastases.","24573639",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24656494","Effects of low-level laser therapy on the proliferation and apoptosis of gingival fibroblasts treated with zoledronic acid.","24656494",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24724423","[Effects of four bisphosphonates on macrophage phagocytosis: quantitative measurement by flow cytometry using high-fluorescence particles and human monocytic cell line THP-1].","24724423",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24762323","Zoledronic acid and geranylgeraniol regulate cellular behaviour and angiogenic gene expression in human gingival fibroblasts.","24762323",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2014,"24865775","Immunohistochemical expression of caspase-3, caspase-5, caspase-7 and apoptotic protease-activating factor-1 (APAF-1) in the liver and kidney of rats exposed to zoledronic acid (ZOL) and basic fibroblast growth factor (bFGF).","24865775",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24912747","Zoledronic acid causes γδ T cells to target monocytes and down-modulate inflammatory homing.","24912747",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24947610","Laser-enhanced cytotoxicity of zoledronic acid and cisplatin on primary human fibroblasts and head and neck squamous cell carcinoma cell line UM-SCC-3.","24947610",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24963720","Reactive oxygen species and autophagy associated apoptosis and limitation of clonogenic survival induced by zoledronic acid in salivary adenoid cystic carcinoma cell line SACC-83.","24963720",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24975838","Zoledronic acid affects the cytotoxic effects of Chlamydia pneumoniae and the modulation of cytokine production in human osteosarcoma cells.","24975838",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"25016096","Activation of p38 MAPK-regulated Bcl-xL signaling increases survival against zoledronic acid-induced apoptosis in osteoclast precursors.","25016096",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25055744","Zoledronic acid at subtoxic dose extends osteoblastic stage span of primary human osteoblasts.","25055744",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2015,"25055746","Mechanical loading influences the effects of bisphosphonates on human periodontal ligament fibroblasts.","25055746",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"25098623","Everolimus and zoledronic acid--a potential synergistic treatment for lung adenocarcinoma bone metastasis.","25098623",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"25111384","Enhanced anti-tumor effect of zoledronic acid combined with temozolomide against human malignant glioma cell expressing O6-methylguanine DNA methyltransferase.","25111384",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"25138053","Clusterin inhibition using OGX-011 synergistically enhances zoledronic acid activity in osteosarcoma.","25138053",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"25142231","Zoledronic acid induces apoptosis and autophagy in cervical cancer cells.","25142231",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25167891","Effects of bisphosphonate zoledronic acid in hepatocellular carcinoma, depending on mevalonate pathway.","25167891",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25293519","Zoledronic acid increases cytotoxicity by inducing apoptosis in hormone and docetaxel-resistant prostate cancer cell lines.","25293519",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"25312823","Zoledronic acid exerts antitumor effects in NB4 acute promyelocytic leukemia cells by inducing apoptosis and S phase arrest.","25312823",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"25393473","Zoledronic acid induces apoptosis and S-phase arrest in mesothelioma through inhibiting Rab family proteins and topoisomerase II actions.","25393473",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"25431953","Medical treatment of orthotopic glioblastoma with transferrin-conjugated nanoparticles encapsulating zoledronic acid.","25431953",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"25496233","Probenecid as a sensitizer of bisphosphonate-mediated effects in breast cancer cells.","25496233",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2014,"25536616","Enhanced cytotoxicity and apoptosis by thymoquinone in combination with zoledronic acid in hormone- and drug-resistant prostate cancer cell lines.","25536616",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25646931","Prenylation inhibition-induced cell death in melanoma: reduced sensitivity in BRAF mutant/PTEN wild-type melanoma cells.","25646931",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25682285","Zoledronate can promote apoptosis and inhibit the proliferation of colorectal cancer cells.","25682285",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25913629","The influence of geranylgeraniol on human oral keratinocytes after bisphosphonate treatment: An in vitro study.","25913629",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25934567","Extracellular Ca(2+)-dependent enhancement of cytocidal potency of zoledronic acid in human oral cancer cells.","25934567",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C343491,B343491)","v":"zoledronic acid"},"zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J343491,K343491)","v":"Apoptosis"},"D017209","Apoptosis",1,2,2016,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q343491,Q343491)","v":"26201455"},"PRGF exerts a cytoprotective role in zoledronic acid-treated oral cells.","26201455",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"26235741","Synergistic suppression of human breast cancer cells by combination of plumbagin and zoledronic acid In vitro.","26235741",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"26343372","Bisphosphonate-induced differential modulation of immune cell function in gingiva and bone marrow in vivo: role in osteoclast-mediated NK cell activation.","26343372",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"26372812","Self-assembling nanoparticles encapsulating zoledronic acid revert multidrug resistance in cancer cells.","26372812",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"26462835","Combination of zoledronic acid and serine/threonine phosphatase inhibitors induces synergistic cytotoxicity and apoptosis in human breast cancer cells via inhibition of PI3K/Akt pathway.","26462835",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"26646564","Zoledronic acid induces apoptosis via stimulating the expressions of ERN1, TLR2, and IRF5 genes in glioma cells.","26646564",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"26648136","Dose-dependent inhibitory effects of zoledronic acid on osteoblast viability and function in vitro.","26648136",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2016,"26678828","Revival of nitrogen-containing bisphosphonate-induced inhibition of osteoclastogenesis and osteoclast function by water-soluble microfibrous borate glass.","26678828",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"26712686","Blocking HSP90 Addiction Inhibits Tumor Cell Proliferation, Metastasis Development, and Synergistically Acts with Zoledronic Acid to Delay Osteosarcoma Progression.","26712686",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"26757761","[Effect of zoledronic acid on cell proliferation and apoptosis of human periodontal fibroblasts].","26757761",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"26763733","Folate-targeted pH-responsive calcium zoledronate nanoscale metal-organic frameworks: Turning a bone antiresorptive agent into an anticancer therapeutic.","26763733",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2016,"26795621","Effects of zoledronic acid and geranylgeraniol on the cellular behaviour and gene expression of primary human alveolar osteoblasts.","26795621",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"26851017","Development of Stemness in Cancer Cell Lines Resistant to the Anticancer Effects of Zoledronic Acid.","26851017",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"26891667","Platinum-zoledronate complex blocks gastric cancer cell proliferation by inducing cell cycle arrest and apoptosis.","26891667",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"26905520","The miR-21/PTEN/Akt signaling pathway is involved in the anti-tumoral effects of zoledronic acid in human breast cancer cell lines.","26905520",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2016,"26968247","Combined inhibition of the mevalonate pathway with statins and zoledronic acid potentiates their anti-tumor effects in human breast cancer cells.","26968247",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2016,"26976978","Inhibition of Survivin Is Associated with Zoledronic Acid-induced Apoptosis of Prostate Cancer Cells.","26976978",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"26980746","Zoledronic acid-encapsulating self-assembling nanoparticles and doxorubicin: a combinatorial approach to overcome simultaneously chemoresistance and immunoresistance in breast tumors.","26980746",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27344431","Influence of zoledronic acid on proliferation, migration, and apoptosis of vascular endothelial cells.","27344431",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27405588","Combination of a third generation bisphosphonate and replication-competent adenoviruses augments the cytotoxicity on mesothelioma.","27405588",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27573706","Apoptosis repressor with caspase recruitment domain enhances survival and promotes osteogenic differentiation of human osteoblast cells under Zoledronate treatment.","27573706",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27748838","Zoledronate induces autophagic cell death in human umbilical vein endothelial cells via Beclin-1 dependent pathway activation.","27748838",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27765919","Zoledronic acid is an effective radiosensitizer in the treatment of osteosarcoma.","27765919",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27780929","KRAS-mutation status dependent effect of zoledronic acid in human non-small cell cancer preclinical models.","27780929",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27878279","Zoledronic acid overcomes adriamycin resistance in acute myeloid leukemia cells by promoting apoptosis.","27878279",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27916903","Combined Use of Zoledronic Acid Augments Ursolic Acid-Induced Apoptosis in Human Osteosarcoma Cells through Enhanced Oxidative Stress and Autophagy.","27916903",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2017,"28685948","Role of zoledronic acid in oncolytic virotherapy: Promotion of antitumor effect and prevention of bone destruction.","28685948",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28945801","Estradiol impairs the antiproliferative and proapoptotic effect of Zoledronic acid in hormone sensitive breast cancer cells in vitro.","28945801",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2018,"29025652","High-activity chitosan/nano hydroxyapatite/zoledronic acid scaffolds for simultaneous tumor inhibition, bone repair and infection eradication.","29025652",136]
["zoledronic acid","zoledronic acid","C088658","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,1998,"9519785","In vitro cytoreductive effects on multiple myeloma cells induced by bisphosphonates.","9519785",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2005,"16121404","Zoledronic acid inhibits primary bone tumor growth in Ewing sarcoma.","16121404",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2004,"15494642","In vitro toxicity of bisphosphonates on human neuroblastoma cell lines.","15494642",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2005,"15603852","Efficacy of the third-generation bisphosphonate, zoledronic acid alone and combined with anti-cancer agents against small cell lung cancer cell lines.","15603852",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2005,"15839301","Zoledronic acid mediates Ras-independent growth inhibition of prostate cancer cells.","15839301",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2005,"15895374","Zoledronic acid down-regulates adhesion molecules of bone marrow stromal cells in multiple myeloma: a possible mechanism for its antitumor effect.","15895374",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2005,"15999121","Comparison of Fc-osteoprotegerin and zoledronic acid activities suggests that zoledronic acid inhibits prostate cancer in bone by indirect mechanisms.","15999121",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2005,"16012525","Evolving therapeutic role of bisphosphonates in multiple myeloma.","16012525",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2005,"16019470","Zoledronic acid exerts its antitumor effect in multiple myeloma interfering with the bone marrow microenvironment.","16019470",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2005,"16046524","RAS-blocking bisphosphonate zoledronic acid inhibits the abnormal proliferation and differentiation of juvenile myelomonocytic leukemia cells in vitro.","16046524",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2005,"16096432","Combined effects of zoledronic acid and doxorubicin on breast cancer cell invasion in vitro.","16096432",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2005,"16167056","Zoledronate inhibits proliferation and induces apoptosis of imatinib-resistant chronic myeloid leukaemia cells.","16167056",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2007,"17311867","Morphoproteomic expression of H-ras (p21ras) correlates with serum monoclonal immunoglobulin reduction in multiple myeloma patients following pamidronate treatment.","17311867",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2006,"16539721","Zoledronic acid treatment impairs protein geranyl-geranylation for biological effects in prostatic cells.","16539721",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2006,"16570273","Zoledronic acid slows down rat primary chondrosarcoma development, recurrent tumor progression after intralesional curretage and increases overall survival.","16570273",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2007,"16621245","Differential effects of bisphosphonates on breast cancer cell lines.","16621245",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2006,"16698685","Type I IFN-mediated enhancement of anti-leukemic cytotoxicity of gammadelta T cells expanded from peripheral blood cells by stimulation with zoledronate.","16698685",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2006,"16904974","Efficacy of zoledronate against neuroblastoma.","16904974",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2006,"16925824","In vitro synergistic cytoreductive effects of zoledronic acid and radiation on breast cancer cells.","16925824",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2007,"16939689","Cytotoxic activity of the third-generation bisphosphonate zoledronic acid in acute myeloid leukemia.","16939689",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2007,"16996129","Inhibitors of the mevalonate pathway as potential therapeutic agents in multiple myeloma.","16996129",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2006,"17070308","Antitumor effects of aminobisphosphonates on renal cell carcinoma cell lines.","17070308",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2007,"17192846","R115777 (Zarnestra)/Zoledronic acid (Zometa) cooperation on inhibition of prostate cancer proliferation is paralleled by Erk/Akt inactivation and reduced Bcl-2 and bad phosphorylation.","17192846",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2007,"17403919","Enhanced ability of dendritic cells to stimulate innate and adaptive immunity on short-term incubation with zoledronic acid.","17403919",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2007,"17418595","Cisplatin cytotoxicity is enhanced with zoledronic acid in A549 lung cancer cell line: preliminary results of an in vitro study.","17418595",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2007,"17457212","Zoledronic acid has direct antiproliferative and antimetastatic effect on pancreatic carcinoma cells and acts as an antigen for delta2 gamma/delta T cells.","17457212",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2007,"17562444","The in vitro anti-tumour activity of zoledronic acid and docetaxel at clinically achievable concentrations in prostate cancer.","17562444",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"19003973","Inhibition of osteoblast function in vitro by aminobisphosphonates.","19003973",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2007,"17611684","Zoledronate-induced S phase arrest and apoptosis accompanied by DNA damage and activation of the ATM/Chk1/cdc25 pathway in human osteosarcoma cells.","17611684",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2008,"17900752","Zoledronic acid is unable to induce apoptosis, but slows tumor growth and prolongs survival for non-small-cell lung cancers.","17900752",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2008,"17960623","Relevance of a new rat model of osteoblastic metastases from prostate carcinoma for preclinical studies using zoledronic acid.","17960623",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2007,"18163982","Osteosarcoma cell line growth inhibition by zoledronate-stimulated effector cells.","18163982",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2008,"18190680","Extracellular calcium increases bisphosphonate-induced growth inhibition of breast cancer cells.","18190680",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2008,"18388351","Zoledronic acid is effective against experimental malignant pleural effusion.","18388351",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2008,"18423279","Histomorphometric evaluation of the effects of zoledronic acid on mandibular distraction osteogenesis in rabbits.","18423279",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C343555,B343555)","v":"zoledronic acid"},"zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J343555,K343555)","v":"Cell Proliferation"},"D049109","Cell Proliferation",1,2,2008,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q343555,Q343555)","v":"18437576"},"The bisphosphonate zoledronic acid inhibits the growth of HCT-116 colon carcinoma cells and induces tumor cell apoptosis.","18437576",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2008,"18454049","Bisphosphonate-induced ATP analog formation and its effect on inhibition of cancer cell growth.","18454049",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2008,"18494934","Farnesyl diphosphate synthase is involved in the resistance to zoledronic acid of osteosarcoma cells.","18494934",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2008,"18507039","Antitumoral and antiangiogenic efficacy of bisphosphonates in vitro and in a murine RENCA model.","18507039",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2008,"18601766","Zoledronic acid effects interleukin-6 expression in hormone-independent prostate cancer cell lines.","18601766",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2008,"18695136","Antitumor effects of doxorubicin followed by zoledronic acid in a mouse model of breast cancer.","18695136",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"18986762","Clinically relevant dose of zoledronic acid inhibits spontaneous lung metastasis in a murine osteosarcoma model.","18986762",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"19000670","Zoledronate inhibits the proliferation, adhesion and migration of vascular smooth muscle cells.","19000670",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2008,"19016372","Zoledronate facilitates large-scale ex vivo expansion of functional gammadelta T cells from cancer patients for use in adoptive immunotherapy.","19016372",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"19036117","Effect of zoledronic acid on oral fibroblasts and epithelial cells: a potential mechanism of bisphosphonate-associated osteonecrosis.","19036117",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"19621390","The bisphosphonate zoledronic acid has antimyeloma activity in vivo by inhibition of protein prenylation.","19621390",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"19139120","Intensification therapy with anti-parathyroid hormone-related protein antibody plus zoledronic acid for bone metastases of small cell lung cancer cells in severe combined immunodeficient mice.","19139120",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2009,"19400555","Induction of gamma delta T cells using zoledronate plus interleukin-2 in patients with metastatic cancer.","19400555",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"19401351","Zoledronic acid inhibits both the osteolytic and osteoblastic components of osteosarcoma lesions in a mouse model.","19401351",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"19414350","Indirect antitumor effects of bisphosphonates on prostatic LNCaP cells co-cultured with bone cells.","19414350",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"19442618","Pulse treatment with zoledronic acid causes sustained commitment of bone marrow derived mesenchymal stem cells for osteogenic differentiation.","19442618",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"19464430","Zoledronic acid determines S-phase arrest but fails to induce apoptosis in cholangiocarcinoma cells.","19464430",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"19530242","Cyr61 downmodulation potentiates the anticancer effects of zoledronic acid in androgen-independent prostate cancer cells.","19530242",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"19577359","Zoledronic acid induces apoptosis and changes the TRAIL/OPG ratio in breast cancer cells.","19577359",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"19642368","[Effect of zoledronic acid on the growth and CD138 expression of myeloma cell line KM3].","19642368",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"19653010","A novel bioassay model to determine clinically significant bisphosphonate levels.","19653010",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"19716895","Targeting apoptosis in the hormone- and drug-resistant prostate cancer cell line, DU-145, by gossypol/zoledronic acid combination.","19716895",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"19789217","Anticancer mechanisms of doxorubicin and zoledronic acid in breast cancer tumor growth in bone.","19789217",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"19825521","Combined gossypol and zoledronic acid treatment results in synergistic induction of cell death and regulates angiogenic molecules in ovarian cancer cells.","19825521",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"19882100","Zoledronic acid delays wound healing of the tooth extraction socket, inhibits oral epithelial cell migration, and promotes proliferation and adhesion to hydroxyapatite of oral bacteria, without causing osteonecrosis of the jaw, in mice.","19882100",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"19914061","Bortezomib and zoledronic acid on angiogenic and vasculogenic activities of bone marrow macrophages in patients with multiple myeloma.","19914061",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"19924813","Zoledronic acid protects against osteosarcoma-induced bone destruction but lacks efficacy against pulmonary metastases in a syngeneic rat model.","19924813",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20048108","Cytotoxic effect of zoledronic acid-loaded bone cement on giant cell tumor, multiple myeloma, and renal cell carcinoma cell lines.","20048108",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20514467","Zoledronic acid inhibits proliferation of human fibrosarcoma cells with induction of apoptosis, and shows combined effects with other anticancer agents.","20514467",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20160726","Combined effects of the bisphosphonate, zoledronic acid and the aromatase inhibitor letrozole on breast cancer cells in vitro: evidence of synergistic interaction.","20160726",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"20349282","Regulation of apoptosis-related molecules by synergistic combination of all-trans retinoic acid and zoledronic acid in hormone-refractory prostate cancer cell lines.","20349282",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20431297","Microvascular endothelial cell responses in vitro and in vivo: modulation by zoledronic acid and paclitaxel?","20431297",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20445349","Effect of IL-18 on expansion of gammadelta T cells stimulated by zoledronate and IL-2.","20445349",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20491785","In vivo manipulation of Vgamma9Vdelta2 T cells with zoledronate and low-dose interleukin-2 for immunotherapy of advanced breast cancer patients.","20491785",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20549316","Coculturing dendritic cells with zoledronate acid efficiently enhance the anti-tumor effects of cytokine-induced killer cells.","20549316",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2010,"20582413","Aminobisphosphonate-pretreated dendritic cells trigger successful Vgamma9Vdelta2 T cell amplification for immunotherapy in advanced cancer patients.","20582413",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20618968","The impact of bisphosphonates on the osteoblast proliferation and Collagen gene expression in vitro.","20618968",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20646644","[Study of sequence-dependent in vitro effects of zoledronic acid and paclitaxel upon DU145 prostate cancer cells].","20646644",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"20831354","Zoledronate-activated Vγ9γδ T cell-based immunotherapy is feasible and restores the impairment of γδ T cells in patients with solid tumors.","20831354",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"20860766","In vivo effects of zoledronic acid on oral mucosal epithelial cells.","20860766",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20879838","Anticancer properties of zoledronic acid.","20879838",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"20890703","Cytotoxic effect of clodronate and zoledronate on the chondrosarcoma cell lines HTB-94 and CAL-78.","20890703",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"20920623","Nitrogen-containing bisphosphonates can inhibit angiogenesis in vivo without the involvement of farnesyl pyrophosphate synthase.","20920623",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20920980","Bisphosphonates as anticancer therapy for early breast cancer.","20920980",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"20926944","Zoledronic acid induces cell-cycle prolongation in murine lung cancer cells by perturbing cyclin and Ras expression.","20926944",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20971371","Osteonecrosis of the jaw: effect of bisphosphonate type, local concentration, and acidic milieu on the pathomechanism.","20971371",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"20977926","The proapoptotic effect of zoledronic acid is independent of either the bone microenvironment or the intrinsic resistance to bortezomib of myeloma cells and is enhanced by the combination with arsenic trioxide.","20977926",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21055454","Self-assembly nanoparticles for the delivery of bisphosphonates into tumors.","21055454",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2010,"21122371","[Effect of zoledronic acid on the differentiation and osteoprotegerin production of osteoblasts in rabbit].","21122371",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21123096","Zoledronate inhibits intimal hyperplasia in balloon-injured rat carotid artery.","21123096",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21146154","Bisphosphonate effects on the behaviour of oral epithelial cells and oral fibroblasts.","21146154",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"21205463","Dose-dependent metabolic effect of zoledronate on primary human osteoblastic cell cultures.","21205463",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"21225298","The influence of bisphosphonates on viability, migration, and apoptosis of human oral keratinocytes--in vitro study.","21225298",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21249320","Zoledronic acid, a third-generation bisphosphonate, inhibits cellular growth and induces apoptosis in oral carcinoma cell lines.","21249320",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21304399","Adoptive immunotherapy for advanced non-small cell lung cancer using zoledronate-expanded γδTcells: a phase I clinical study.","21304399",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21353178","The backbone of progress--preclinical studies and innovations with zoledronic acid.","21353178",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21393426","CCN1, a candidate target for zoledronic acid treatment in breast cancer.","21393426",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21426781","[Study on the effects of zoledronic-acid-loaded collagen membrane on bone metabolism cells].","21426781",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"21431960","Zoledronic acid inhibits proliferation and impairs migration and invasion through downregulating VEGF and MMPs expression in human nasopharyngeal carcinoma cells.","21431960",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21453789","Nanotechnologies to use bisphosphonates as potent anticancer agents: the effects of zoledronic acid encapsulated into liposomes.","21453789",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21530208","Short-term effects of zoledronate on the histomorphology of osteoclast in young albino rats.","21530208",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"21604021","Cytotoxicity of the new antimetabolite-bisphosphonate (5-FdU-alendronate) in comparison to standard therapeutics on breast and ovarian cancer cell lines in the ATP tumor chemosensitivity assay.","21604021",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"21741464","New self-assembly nanoparticles and stealth liposomes for the delivery of zoledronic acid: a comparative study.","21741464",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2011,"21753152","Immune modulation by zoledronic acid in human myeloma: an advantageous cross-talk between Vγ9Vδ2 T cells, αβ CD8+ T cells, regulatory T cells, and dendritic cells.","21753152",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C343619,B343619)","v":"zoledronic acid"},"zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J343619,K343619)","v":"Cell Proliferation"},"D049109","Cell Proliferation",1,2,2011,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q343619,Q343619)","v":"21807448"},"Novel therapy to reverse the cellular effects of bisphosphonates on primary human oral fibroblasts.","21807448",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"21954965","Significance of combination therapy of zoledronic acid and gemcitabine on pancreatic cancer.","21954965",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22014461","The effect of zoledronate-hydroxyapatite nanocomposites on osteoclasts and osteoblast-like cells in vitro.","22014461",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"22075551","Zoledronic acid modulates maturation of human monocyte-derived dendritic cells.","22075551",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22082730","The cytotoxic effects of three different bisphosphonates in-vitro on human gingival fibroblasts, osteoblasts and osteogenic sarcoma cells.","22082730",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"22094096","[Inhibitory effects of zoledronic acid on cell proliferation and invasion in human nasopharyngeal carcinoma cell line HNE1].","22094096",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22172403","Zoledronic acid induces S-phase arrest via a DNA damage response in normal human oral keratinocytes.","22172403",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22182245","Low concentration amino-bisphosphonates stimulate human keratinocyte proliferation and in vitro wound healing.","22182245",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2012,"22260151","Analysis of molecular mechanisms and anti-tumoural effects of zoledronic acid in breast cancer cells.","22260151",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22322451","Involvement of the mevalonate pathway in the antiproliferative effect             of zoledronate on ACHN renal cell carcinoma cells.","22322451",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22450844","Zoledronic acid influences growth, migration and invasive activity of prostate cancer cells in vitro.","22450844",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22481236","Zoledronic acid produces antitumor effects on mesothelioma through apoptosis and S-phase arrest in p53-independent and Ras prenylation-independent manners.","22481236",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22563819","Zoledronic acid suppresses mineralization through direct cytotoxicity and osteoblast differentiation inhibition.","22563819",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"22571861","Effect of low level laser therapy and zoledronate on the viability and ALP activity of Saos-2 cells.","22571861",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23164362","Differential effect of zoledronic acid on human vascular smooth muscle cells.","23164362",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22650360","Exposing human epithelial cells to zoledronic acid can mediate osteonecrosis of jaw: an in vitro model.","22650360",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22729369","Zoledronic acid inhibits human nasopharyngeal carcinoma cell proliferation by activating mitochondrial apoptotic pathway.","22729369",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22781776","[Study of sequence-dependent in vitro effects of zoledronic acid and paclitaxel upon human nasopharyngeal carcinoma cell line HNE1].","22781776",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2013,"22864527","Oral mucosa produces cytokines and factors influencing osteoclast activity and endothelial cell proliferation, in patients with osteonecrosis of jaw after treatment with zoledronic acid.","22864527",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22882676","Zoledronic acid in combination with serine/threonine phosphatase inhibitors induces enhanced cytotoxicity and apoptosis in hormone-refractory prostate cancer cell lines by decreasing the activities of PP1 and PP2A.","22882676",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22884656","Expression of matrix macromolecules and functional properties of breast cancer cells are modulated by the bisphosphonate zoledronic acid.","22884656",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"22996996","Zoledronic acid but not somatostatin analogs exerts anti-tumor effects in a model of murine prostatic neuroendocrine carcinoma of the development of castration-resistant prostate cancer.","22996996",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2012,"22997885","[Zoledronic acid incorporated in chitosan/calcium phosphate ceramic: characterization and in vitro response of osteoblast cells].","22997885",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23321500","Potent antitumor activity of zoledronic acid-induced Vγ9Vδ2 T cells against primary effusion lymphoma.","23321500",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23428615","Low zoledronate concentrations stimulate human keratinocyte proliferation.","23428615",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2013,"23525469","Zoledronic acid negatively affects the expansion of in vitro activated human NK cells and their cytolytic interactions with Ewing sarcoma cells.","23525469",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"23627025","[The comparison between HIV-infected patients' Vdelta2 T cells expansion efficiencies by zoledronic acid and gammadelta TCR monoclonal antibody in vitro].","23627025",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23725755","STAT pathway in the regulation of zoledronic acid-induced apoptosis in chronic myeloid leukemia cells.","23725755",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23794630","Essential requirements of zoledronate-induced cytokine and γδ T cell proliferative responses.","23794630",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23807419","Bisphosphonates modulate vital functions of human osteoblasts and affect their interactions with breast cancer cells.","23807419",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23835291","A randomized phase II trial evaluating different schedules of zoledronic acid on bone mineral density in patients with prostate cancer beginning androgen deprivation therapy.","23835291",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23869361","Physicochemical, pharmacologic, and in vitro cellular effects of loading collagen membranes with zoledronic acid.","23869361",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23898082","Effects of bisphosphonates in combination with ionizing radiation and antioxidants on the growth of prostate and melanoma cells lines.","23898082",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2013,"24036536","Zoledronic acid inhibits macrophage/microglia-assisted breast cancer cell invasion.","24036536",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"24060052","Comparison of the anti-tumor effects of denosumab and zoledronic acid on the neoplastic stromal cells of giant cell tumor of bone.","24060052",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24162933","Neutrophil uptake of nitrogen-bisphosphonates leads to the suppression of human peripheral blood γδ T cells.","24162933",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"24177992","Macrophages as potential targets for zoledronic acid outside the skeleton-evidence from in vitro and in vivo models.","24177992",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24287290","The cell cycle arrest and the anti-invasive effects of nitrogen-containing bisphosphonates are not mediated by DBF4 in breast cancer cells.","24287290",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24316794","In vitro antitumor effect of sodium butyrate and zoledronic acid combined with traditional chemotherapeutic drugs: a paradigm of synergistic molecular targeting in the treatment of Ewing sarcoma.","24316794",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"24324070","Lung cancer cell line sensitivity to Zoledronic acid is BAX-dependent.","24324070",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24342576","In vitro effect of bisphosphonates on oral keratinocytes and fibroblasts.","24342576",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24373581","Bisphosphonates induce the osteogenic gene expression in co-cultured human endothelial and mesenchymal stem cells.","24373581",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24443409","Bisphosphonates inhibit osteosarcoma-mediated osteolysis via attenuation of tumor expression of MCP-1 and RANKL.","24443409",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24598781","Induced pluripotent stem cells reveal functional differences between drugs currently investigated in patients with hutchinson-gilford progeria syndrome.","24598781",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24656494","Effects of low-level laser therapy on the proliferation and apoptosis of gingival fibroblasts treated with zoledronic acid.","24656494",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24731709","Combined effect of strontium and zoledronate on hydroxyapatite structure and bone cell responses.","24731709",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24947610","Laser-enhanced cytotoxicity of zoledronic acid and cisplatin on primary human fibroblasts and head and neck squamous cell carcinoma cell line UM-SCC-3.","24947610",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24963720","Reactive oxygen species and autophagy associated apoptosis and limitation of clonogenic survival induced by zoledronic acid in salivary adenoid cystic carcinoma cell line SACC-83.","24963720",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"25016096","Activation of p38 MAPK-regulated Bcl-xL signaling increases survival against zoledronic acid-induced apoptosis in osteoclast precursors.","25016096",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"25111384","Enhanced anti-tumor effect of zoledronic acid combined with temozolomide against human malignant glioma cell expressing O6-methylguanine DNA methyltransferase.","25111384",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2014,"25116261","The tumor-educated-macrophage increase of malignancy of human pancreatic cancer is prevented by zoledronic acid.","25116261",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"25138053","Clusterin inhibition using OGX-011 synergistically enhances zoledronic acid activity in osteosarcoma.","25138053",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25203609","Evaluation of antitumor effect of zoledronic acid entrapped in folate-linked liposome for targeting to tumor-associated macrophages.","25203609",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25293519","Zoledronic acid increases cytotoxicity by inducing apoptosis in hormone and docetaxel-resistant prostate cancer cell lines.","25293519",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25462224","Synthesis, crystal structure and antitumor effect of a novel copper(II) complex bearing zoledronic acid derivative.","25462224",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2015,"25481874","Proteomic analysis of zoledronic-acid resistant prostate cancer cells unveils novel pathways characterizing an invasive phenotype.","25481874",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"25482949","Nanoparticles for the delivery of zoledronic acid to prostate cancer cells: a comparative analysis through time lapse video-microscopy technique.","25482949",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"25483657","The effects of zoledronate on monocyte-derived dendritic cells from melanoma patients differ depending on the clinical stage of the disease.","25483657",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2014,"25536616","Enhanced cytotoxicity and apoptosis by thymoquinone in combination with zoledronic acid in hormone- and drug-resistant prostate cancer cell lines.","25536616",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25544757","Zoledronic acid overcomes chemoresistance and immunosuppression of malignant mesothelioma.","25544757",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25588705","Liposome encapsulated zoledronate favours M1-like behaviour in murine macrophages cultured with soluble factors from breast cancer cells.","25588705",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25682285","Zoledronate can promote apoptosis and inhibit the proliferation of colorectal cancer cells.","25682285",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25884855","The differential anti-tumour effects of zoledronic acid in breast cancer - evidence for a role of the activin signaling pathway.","25884855",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25913629","The influence of geranylgeraniol on human oral keratinocytes after bisphosphonate treatment: An in vitro study.","25913629",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C343683,B343683)","v":"zoledronic acid"},"zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J343683,K343683)","v":"Cell Proliferation"},"D049109","Cell Proliferation",1,2,2015,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q343683,Q343683)","v":"25934567"},"Extracellular Ca(2+)-dependent enhancement of cytocidal potency of zoledronic acid in human oral cancer cells.","25934567",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25998578","The combined use of Camellia sinensis and metronomic zoledronate in 4T1 mouse carcinoma against tumor growth and metastasis.","25998578",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"26026888","Cytoprotective effects of melatonin on zoledronic acid-treated human mesenchymal stem cells in vitro.","26026888",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"26071219","Trastuzumab enhanced the cytotoxicity of Vγ9Vδ2 T cells against zoledronate-sensitized osteosarcoma cells.","26071219",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"26126921","Zoledronic acid inhibits the pentose phosphate pathway through attenuating the Ras-TAp73-G6PD axis in bladder cancer cells.","26126921",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"26201455","PRGF exerts a cytoprotective role in zoledronic acid-treated oral cells.","26201455",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2015,"26203666","Human stromal cells are required for an anti-breast cancer effect of zoledronic acid.","26203666",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"26372812","Self-assembling nanoparticles encapsulating zoledronic acid revert multidrug resistance in cancer cells.","26372812",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"26437179","Combination therapy with zoledronic acid and cetuximab effectively suppresses growth of colorectal cancer cells regardless of KRAS status.","26437179",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"26564742","[The influence of zoledronic acid on vascular endothelial cell].","26564742",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"26572124","The effects of zoledronate on the survival and function of human osteoblast-like cells.","26572124",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2016,"26658366","The bisphosphonate zoledronic acid regulates key angiogenesis-related genes in primary human gingival fibroblasts.","26658366",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"26679354","Zoledronate Attenuates Accumulation of DNA Damage in Mesenchymal Stem Cells and Protects Their Function.","26679354",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"26712686","Blocking HSP90 Addiction Inhibits Tumor Cell Proliferation, Metastasis Development, and Synergistically Acts with Zoledronic Acid to Delay Osteosarcoma Progression.","26712686",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"26757761","[Effect of zoledronic acid on cell proliferation and apoptosis of human periodontal fibroblasts].","26757761",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"26795621","Effects of zoledronic acid and geranylgeraniol on the cellular behaviour and gene expression of primary human alveolar osteoblasts.","26795621",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"26851017","Development of Stemness in Cancer Cell Lines Resistant to the Anticancer Effects of Zoledronic Acid.","26851017",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"26891667","Platinum-zoledronate complex blocks gastric cancer cell proliferation by inducing cell cycle arrest and apoptosis.","26891667",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27301207","Transferrin-Targeted Nanoparticles Containing Zoledronic Acid as a Potential Tool to Inhibit Glioblastoma Growth.","27301207",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"26936487","Hepatocellular carcinoma cell sensitivity to Vγ9Vδ2 T lymphocyte-mediated killing is increased by zoledronate.","26936487",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"26976978","Inhibition of Survivin Is Associated with Zoledronic Acid-induced Apoptosis of Prostate Cancer Cells.","26976978",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"26980746","Zoledronic acid-encapsulating self-assembling nanoparticles and doxorubicin: a combinatorial approach to overcome simultaneously chemoresistance and immunoresistance in breast tumors.","26980746",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27109760","Zoledronic acid increases the antitumor effect of gefitinib treatment for non-small cell lung cancer with EGFR mutations.","27109760",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27122094","The enhancing effect of a laser photochemotherapy with cisplatin or zolendronic acid in primary human osteoblasts and osteosarcoma cells in vitro.","27122094",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27181081","Synergistic Antiproliferative Effects of Zoledronic Acid and Fluvastatin on Human Pancreatic Cancer Cell Lines: An in Vitro Study.","27181081",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2016,"27196705","Zoledronic acid in vivo increases in vitro proliferation of rat mesenchymal stromal cells.","27196705",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27252151","Biocomposite macroporous cryogels as potential carrier scaffolds for bone active agents augmenting bone regeneration.","27252151",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27344431","Influence of zoledronic acid on proliferation, migration, and apoptosis of vascular endothelial cells.","27344431",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27405588","Combination of a third generation bisphosphonate and replication-competent adenoviruses augments the cytotoxicity on mesothelioma.","27405588",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27462771","Anti-cancer effects of nitrogen-containing bisphosphonates on human cancer cells.","27462771",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"27736364","Pretreatment with Bisphosphonate Enhances Osteogenesis of Bone Marrow Mesenchymal Stem Cells.","27736364",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27780929","KRAS-mutation status dependent effect of zoledronic acid in human non-small cell cancer preclinical models.","27780929",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2017,"27865798","Adoptive transfer of ex vivo expanded Vγ9Vδ2 T cells in combination with zoledronic acid inhibits cancer growth and limits osteolysis in a murine model of osteolytic breast cancer.","27865798",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27878279","Zoledronic acid overcomes adriamycin resistance in acute myeloid leukemia cells by promoting apoptosis.","27878279",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27901204","Response of a co-culture model of epithelial cells and gingival fibroblasts to zoledronic acid.","27901204",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27916903","Combined Use of Zoledronic Acid Augments Ursolic Acid-Induced Apoptosis in Human Osteosarcoma Cells through Enhanced Oxidative Stress and Autophagy.","27916903",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2017,"28685948","Role of zoledronic acid in oncolytic virotherapy: Promotion of antitumor effect and prevention of bone destruction.","28685948",136]
["zoledronic acid","zoledronic acid","C088658","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28945801","Estradiol impairs the antiproliferative and proapoptotic effect of Zoledronic acid in hormone sensitive breast cancer cells in vitro.","28945801",136]
["zoledronic acid","zoledronic acid","C088658","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2008,"17907244","Bisphosphonate binding affinity as assessed by inhibition of carbonated apatite dissolution in vitro.","17907244",136]
["zoledronic acid","zoledronic acid","C088658","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2010,"20971371","Osteonecrosis of the jaw: effect of bisphosphonate type, local concentration, and acidic milieu on the pathomechanism.","20971371",136]
["zoledronic acid","zoledronic acid","C088658","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"25074494","Zoledronate and ion-releasing resins impair dentin collagen degradation.","25074494",136]
["zoledronic acid","zoledronic acid","C088658","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2015,"26117452","On-cartridge derivatization coupled with solid-phase extraction for the ultra-sensitive determination of minodronic acid in human plasma by LC-MS/MS method.","26117452",136]
["zoledronic acid","zoledronic acid","C088658","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2015,"26318908","The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants.","26318908",136]
["zoledronic acid","zoledronic acid","C088658","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2016,"26763733","Folate-targeted pH-responsive calcium zoledronate nanoscale metal-organic frameworks: Turning a bone antiresorptive agent into an anticancer therapeutic.","26763733",136]
["zoledronic acid","zoledronic acid","C088658","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,2,2005,"15632382","Re: Long-term efficacy of zoledronic acid for the prevention of skeletal complications in patients with metastatic hormone-refractory prostate cancer.","15632382",136]
["zoledronic acid","zoledronic acid","C088658","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2007,"17164581","Bisphosphonate-associated osteonecrosis of the jaw in patients with multiple myeloma and breast cancer.","17164581",136]
["zoledronic acid","zoledronic acid","C088658","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2008,"17896193","The role of surgery in jaw bone necrosis associated with long-term use of bisphosphonates.","17896193",136]
["zoledronic acid","zoledronic acid","C088658","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2008,"18501105","Osteonecrosis of the jaw in patients with multiple myeloma treated with bisphosphonates: definition and management of the risk related to zoledronic acid.","18501105",136]
["zoledronic acid","zoledronic acid","C088658","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2009,"19240969","Osteonecrosis of the jaw in patients with multiple myeloma treated with zoledronic acid.","19240969",136]
["zoledronic acid","zoledronic acid","C088658","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2010,"20066491","Beyond bisphosphonates: photodynamic therapy structurally augments metastatically involved vertebrae and destroys tumor tissue.","20066491",136]
["zoledronic acid","zoledronic acid","C088658","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2010,"21040464","Ovariectomy stimulates and bisphosphonates inhibit intracortical remodeling in the mouse mandible.","21040464",136]
["zoledronic acid","zoledronic acid","C088658","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,2,2011,"21717996","Locally administered zoledronic Acid therapy for giant cell tumor of bone.","21717996",136]
["zoledronic acid","zoledronic acid","C088658","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2012,"21741464","New self-assembly nanoparticles and stealth liposomes for the delivery of zoledronic acid: a comparative study.","21741464",136]
["zoledronic acid","zoledronic acid","C088658","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,2,2013,"24140868","Inhibition of phosphate transporters ameliorates the inflammatory and necrotic side effects of the nitrogen-containing bisphosphonate zoledronate in mice.","24140868",136]
["zoledronic acid","zoledronic acid","C088658","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2014,"24579680","The effect of zoledronic acid on growth plates and high turnover bones.","24579680",136]
["zoledronic acid","zoledronic acid","C088658","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2017,"29109954","Role of Periapical Diseases in Medication-Related Osteonecrosis of the Jaws.","29109954",136]
["zoledronic acid","zoledronic acid","C088658","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2003,"12619933","Zoledronic acid treatment of 5T2MM-bearing mice inhibits the development of myeloma bone disease: evidence for decreased osteolysis, tumor burden and angiogenesis, and increased survival.","12619933",136]
["zoledronic acid","zoledronic acid","C088658","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2004,"15325030","Is hypocalcemia during therapy with zoledronic acid or other bisphosphonates beneficial to cancer patients?","15325030",136]
["zoledronic acid","zoledronic acid","C088658","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2004,"15343380","An amino-bisphosphonate targets MMP-9-expressing macrophages and angiogenesis to impair cervical carcinogenesis.","15343380",136]
["zoledronic acid","zoledronic acid","C088658","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2005,"15767788","Zoledronic acid-related angiogenesis modifications and survival in advanced breast cancer patients.","15767788",136]
["zoledronic acid","zoledronic acid","C088658","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2007,"18006788","Zoledronic acid and angiogenesis.","18006788",136]
["zoledronic acid","zoledronic acid","C088658","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2007,"18056472","Amino-biphosphonate-mediated MMP-9 inhibition breaks the tumor-bone marrow axis responsible for myeloid-derived suppressor cell expansion and macrophage infiltration in tumor stroma.","18056472",136]
["zoledronic acid","zoledronic acid","C088658","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2007,"18089719","Zoledronic acid affects over-angiogenic phenotype of endothelial cells in patients with multiple myeloma.","18089719",136]
["zoledronic acid","zoledronic acid","C088658","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2008,"18388351","Zoledronic acid is effective against experimental malignant pleural effusion.","18388351",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C343747,B343747)","v":"zoledronic acid"},"zoledronic acid","C088658","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J343747,K343747)","v":"Neovascularization, Pathologic"},"D009389","Neovascularization, Pathologic",1,1,2008,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q343747,Q343747)","v":"18630510"},"The bisphosphonate, zoledronic acid reduces experimental neuroblastoma growth by interfering with tumor angiogenesis.","18630510",136]
["zoledronic acid","zoledronic acid","C088658","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2016,"27780929","KRAS-mutation status dependent effect of zoledronic acid in human non-small cell cancer preclinical models.","27780929",136]
["zoledronic acid","zoledronic acid","C088658","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2010,"19818098","Zoledronic acid repolarizes tumour-associated macrophages and inhibits mammary carcinogenesis by targeting the mevalonate pathway.","19818098",136]
["zoledronic acid","zoledronic acid","C088658","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2010,"19914061","Bortezomib and zoledronic acid on angiogenic and vasculogenic activities of bone marrow macrophages in patients with multiple myeloma.","19914061",136]
["zoledronic acid","zoledronic acid","C088658","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2010,"20088792","Can we consider zoledronic acid a new antitumor agent? Recent evidence in clinical setting.","20088792",136]
["zoledronic acid","zoledronic acid","C088658","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2011,"20920623","Nitrogen-containing bisphosphonates can inhibit angiogenesis in vivo without the involvement of farnesyl pyrophosphate synthase.","20920623",136]
["zoledronic acid","zoledronic acid","C088658","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2011,"21353178","The backbone of progress--preclinical studies and innovations with zoledronic acid.","21353178",136]
["zoledronic acid","zoledronic acid","C088658","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2011,"21453789","Nanotechnologies to use bisphosphonates as potent anticancer agents: the effects of zoledronic acid encapsulated into liposomes.","21453789",136]
["zoledronic acid","zoledronic acid","C088658","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2011,"21718535","Zoledronic acid inhibits vasculogenic mimicry in murine osteosarcoma cell line in vitro.","21718535",136]
["zoledronic acid","zoledronic acid","C088658","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2012,"21741464","New self-assembly nanoparticles and stealth liposomes for the delivery of zoledronic acid: a comparative study.","21741464",136]
["zoledronic acid","zoledronic acid","C088658","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2012,"21876554","New role for an established drug? Bisphosphonates as potential anticancer agents.","21876554",136]
["zoledronic acid","zoledronic acid","C088658","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2011,"22044205","Antiangiogenic effects of zoledronate on cancer neovasculature.","22044205",136]
["zoledronic acid","zoledronic acid","C088658","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2012,"22990205","Evaluation of the in vitro and in vivo antiangiogenic effects of denosumab and zoledronic acid.","22990205",136]
["zoledronic acid","zoledronic acid","C088658","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2012,"23014660","Zoledronic acid effectiveness against breast cancer metastases - a role for estrogen in the microenvironment?","23014660",136]
["zoledronic acid","zoledronic acid","C088658","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2013,"23481325","Mechanisms of the antitumor activity of human Vγ9Vδ2 T cells in combination with zoledronic acid in a preclinical model of neuroblastoma.","23481325",136]
["zoledronic acid","zoledronic acid","C088658","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2015,"25203609","Evaluation of antitumor effect of zoledronic acid entrapped in folate-linked liposome for targeting to tumor-associated macrophages.","25203609",136]
["zoledronic acid","zoledronic acid","C088658","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2014,"25483657","The effects of zoledronate on monocyte-derived dendritic cells from melanoma patients differ depending on the clinical stage of the disease.","25483657",136]
["zoledronic acid","zoledronic acid","C088658","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2015,"25929338","Basal and therapy-driven hypoxia-inducible factor-1α confers resistance to endocrine therapy in estrogen receptor-positive breast cancer.","25929338",136]
["zoledronic acid","zoledronic acid","C088658","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2017,"27223431","Zoledronic acid impairs stromal reactivity by inhibiting M2-macrophages polarization and prostate cancer-associated fibroblasts.","27223431",136]
["zoledronic acid","zoledronic acid","C088658","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2017,"28264701","Zoledronic acid alters hematopoiesis and generates breast tumor-suppressive bone marrow cells.","28264701",136]
["zolmitriptan","zolmitriptan","C089750","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2002,"12412822","Preliminary studies of the pharmacokinetics and tolerability of zolmitriptan nasal spray in healthy volunteers.","12412822",136]
["zolmitriptan","zolmitriptan","C089750","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2005,"15899567","A stability indicating LC method for zolmitriptan.","15899567",136]
["zolmitriptan","zolmitriptan","C089750","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2006,"17069426","Zolmitriptan uptake by human intestinal epithelial Caco-2 cells.","17069426",136]
["zolmitriptan","zolmitriptan","C089750","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"17524230","Transport characteristics of zolmitriptan in a human intestinal epithelial cell line Caco-2.","17524230",136]
["zolmitriptan","zolmitriptan","C089750","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"17955967","Extractive spectrophotometric methods for determination of zolmitriptan in tablets.","17955967",136]
["zolmitriptan","zolmitriptan","C089750","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2009,"18931994","A study of the interaction between enantiomers of zolmitriptan and hydroxypropyl-beta-cyclodextrin by capillary electrophoresis.","18931994",136]
["zolmitriptan","zolmitriptan","C089750","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"22913151","Rheological evaluation of thermoreversible and mucoadhesive nasal gels of Zolmitriptan.","22913151",136]
["zolmitriptan","zolmitriptan","C089750","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"24299896","Formulation and in vitro evaluation of xanthan gum-based bilayered mucoadhesive buccal patches of zolmitriptan.","24299896",136]
["zolmitriptan","zolmitriptan","C089750","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2016,"27586132","99mTc-zolmitriptan: radiolabeling, molecular modeling, biodistribution and gamma scintigraphy as a hopeful radiopharmaceutical for lung nuclear imaging.","27586132",136]
["zolmitriptan","zolmitriptan","C089750","7_AO",872,7,"Site of Contact Nasal Tumors","Increase","Nasal Cavity","D009296","Nasal Cavity",1,2,2005,"16362714","Treatment satisfaction with zolmitriptan nasal spray for migraine in a real life setting: results from phase two of the REALIZE study.","16362714",136]
["zolmitriptan","zolmitriptan","C089750","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Nasal Mucosa","D009297","Nasal Mucosa",1,2,2011,"21671836","Preparation and evaluation of zolmitriptan submicron emulsion for rapid and effective nasal absorption in beagle dogs.","21671836",136]
["zolmitriptan","zolmitriptan","C089750","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Nasal Mucosa","D009297","Nasal Mucosa",1,1,2011,"21918918","Surface thermodynamics of mucoadhesive dry powder formulation  of zolmitriptan.","21918918",136]
["zolmitriptan","zolmitriptan","C089750","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Nasal Mucosa","D009297","Nasal Mucosa",1,2,2015,"25676136","Optimization of combinational intranasal drug delivery system for the management of migraine by using statistical design.","25676136",136]
["zolmitriptan","zolmitriptan","C089750","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Nasal Mucosa","D009297","Nasal Mucosa",1,1,2017,"28729175","Brain targeting efficiency of antimigrain drug loaded mucoadhesive intranasal nanoemulsion.","28729175",136]
["zolmitriptan","zolmitriptan","C089750","7_AO",872,7,"Site of Contact Nasal Tumors","Increase","Nose","D009666","Nose",1,1,2005,"16305598","Distribution of intranasal C-zolmitriptan assessed by positron emission tomography.","16305598",136]
["zolmitriptan","zolmitriptan","C089750","7_AO",872,7,"Site of Contact Nasal Tumors","Increase","Nose","D009666","Nose",1,1,2016,"27128792","Trans-nasal zolmitriptan novasomes: in-vitro preparation, optimization and in-vivo evaluation of brain targeting efficiency.","27128792",136]
["zolmitriptan","zolmitriptan","C089750","7_AO",872,7,"Site of Contact Nasal Tumors","Increase","Nose","D009666","Nose",1,1,2016,"27518323","Intranasal Eutectic Powder of Zolmitriptan with Enhanced Bioavailability in the Rat Brain.","27518323",136]
["zolpidem","zolpidem","C049109","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"19138676","Effects of the hypnotic drug zolpidem on cell proliferation and survival in the dentate gyrus of young and old rats.","19138676",136]
["zolpidem","zolpidem","C049109","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1999,"10595727","Determination of zolpidem in serum microsamples by high-performance liquid chromatography and its application to pharmacokinetics in rats.","10595727",136]
["zolpidem","zolpidem","C049109","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2004,"15340190","Electrochemical study of zolpidem at glassy carbon electrode and its determination in a tablet dosage form by differential pulse voltammetry.","15340190",136]
["zolpidem","zolpidem","C049109","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2004,"15675441","Selective potentiometric determination of zolpidem hemitartrate in tablets and biological fluids by using polymeric membrane electrodes.","15675441",136]
["zolpidem","zolpidem","C049109","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"17953656","Replacement of histidine in position 105 in the α₅ subunit by cysteine stimulates zolpidem sensitivity of α₅β₂γ₂ GABA(A) receptors.","17953656",136]
["zolpidem","zolpidem","C049109","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1986,"3818839","High-performance liquid chromatographic determination of zolpidem, a new sleep inducer, in biological fluids with fluorimetric detection.","3818839",136]
["zolpidem","zolpidem","C049109","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Nasal Mucosa","D009297","Nasal Mucosa",1,1,2016,"27189774","Zolpidem Mucoadhesive Formulations for Intranasal Delivery: Characterization, In Vitro Permeability, Pharmacokinetics, and Nasal Ciliotoxicity in Rats.","27189774",136]
["zolpidem","zolpidem","C049109","6_KE",876,6,"Mutations in Critical Genes","Increase","Point Mutation","D017354","Point Mutation",0,1,2005,"15978011","Loss of zolpidem efficacy in the hippocampus of mice with the GABAA receptor gamma2 F77I point mutation.","15978011",136]
["zomepirac","zomepirac","C020549","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2001,"11205870","Dipeptidyl peptidase IV is a target for covalent adduct formation with the acyl glucuronide metabolite of the anti-inflammatory drug zomepirac.","11205870",136]
["zomepirac","zomepirac","C020549","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1985,"2858367","Stability of acyl glucuronides in blood, plasma, and urine: studies with zomepirac.","2858367",136]
["zomepirac","zomepirac","C020549","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1979,"35605","Renal handling of zomepirac sodium (McN-2783-21-98) in the rat.","35605",136]
["zomepirac","zomepirac","C020549","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1986,"3949982","Irreversible binding of zomepirac to plasma protein in vitro and in vivo.","3949982",136]
["zomepirac","zomepirac","C020549","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1984,"6610684","Simultaneous determination of zomepirac and its major metabolite zomepirac glucuronide in human plasma and urine.","6610684",136]
["zomepirac","zomepirac","C020549","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1983,"6638529","Voltammetric studies of zomepirac sodium and its determination in tablets by differential-pulse polarography.","6638529",136]
["zomepirac glucuronide","zomepirac glucuronide","C027368","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1985,"3874742","Effect of probenecid on the formation and elimination of acyl glucuronides: studies with zomepirac.","3874742",136]
["zomepirac glucuronide","zomepirac glucuronide","C027368","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1982,"6128195","Apparent intramolecular acyl migration of zomepirac glucuronide.","6128195",136]
["zomepirac glucuronide","zomepirac glucuronide","C027368","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1984,"6610684","Simultaneous determination of zomepirac and its major metabolite zomepirac glucuronide in human plasma and urine.","6610684",136]
["Zonarol","Zonarol","C000603465","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"25409433","Marine hydroquinone zonarol prevents inflammation and apoptosis in dextran sulfate sodium-induced mice ulcerative colitis.","25409433",136]
["zoniclezole","zoniclezole","C078649","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1992,"1463936","Quantitative determination of a new anticonvulsant (CGS 18416A) in human plasma using capillary gas chromatography/mass spectrometry.","1463936",136]
["zoniporide","zoniporide","C424422","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2009,"19022230","Effects of KR-33028, a novel Na+/H+ exchanger-1 inhibitor, on glutamate-induced neuronal cell death and ischemia-induced cerebral infarct.","19022230",136]
["zoniporide","zoniporide","C424422","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2009,"19022230","Effects of KR-33028, a novel Na+/H+ exchanger-1 inhibitor, on glutamate-induced neuronal cell death and ischemia-induced cerebral infarct.","19022230",136]
["zoniporide","zoniporide","C424422","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2013,"24228483","[Cardioprotective properties of zoniporide studied on experimental ischemia and reperfusion models in rat myocardium].","24228483",136]
["zonisamide","zonisamide","C022189","1_MIE",867,1,"Intracellular pH","Decrease","Acid-Base Equilibrium","D000136","Acid-Base Equilibrium",2,3,2011,"21278619","Metabolic acidosis with topiramate and zonisamide: an assessment of its severity and predictors.","21278619",136]
["zonisamide","zonisamide","C022189","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2010,"20600601","Zonisamide reduces cell death in SH-SY5Y cells via an anti-apoptotic effect and by upregulating MnSOD.","20600601",136]
["zonisamide","zonisamide","C022189","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2013,"24142350","Protective effects of zonisamide against rotenone-induced neurotoxicity.","24142350",136]
["zonisamide","zonisamide","C022189","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24916835","Zonisamide attenuates hyperoxia-induced apoptosis in the developing rat brain.","24916835",136]
["zonisamide","zonisamide","C022189","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2006,"16595139","Determination of zonisamide by a coated monolithic column.","16595139",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C343811,B343811)","v":"zonisamide"},"zonisamide","C022189","1_MIE",867,1,"Intracellular pH","Decrease",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J343811,K343811)","v":"Hydrogen-Ion Concentration"},"D006863","Hydrogen-Ion Concentration",2,2,2008,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q343811,Q343811)","v":"18359199"},"Antiepileptic activity of zonisamide on hippocampal CA3 neurons does not depend on carbonic anhydrase inhibition.","18359199",136]
["zonisamide","zonisamide","C022189","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"24291623","Investigation of the effects of Zn2+, Ca2+ and Na+ ions on the interaction between zonisamide and human serum albumin (HSA) by spectroscopic methods.","24291623",136]
["zonisamide","zonisamide","C022189","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1987,"3435583","General pharmacology of the novel antiepileptic compound zonisamide. 1st communication: effects on central nervous system.","3435583",136]
["zonisamide","zonisamide","C022189","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2011,"21985145","Apparent acute idiosyncratic hepatic necrosis associated with zonisamide administration in a dog.","21985145",136]
["zonisamide","zonisamide","C022189","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,1994,"8082694","Zonisamide reduces hypoxic-ischemic brain damage in neonatal rats irrespective of its anticonvulsive effect.","8082694",136]
["Zonyl","Zonyl","C038646","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1991,"2070379","Effect of a surface-active cation on fluoride/enamel interactions in vitro.","2070379",136]
["zopfiellin","zopfiellin","C470145","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2002,"12428951","pH modulation of zopfiellin antifungal activity to Colletotrichum and Botrytis.","12428951",136]
["zopiclone","zopiclone","C515050","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Atrophy","D001284","Atrophy",1,1,1998,"9628149","Treatment of insomnia by concomitant therapy with Zopiclone and Aniracetam in patients with cerebral infarction, cerebroatrophy, Alzheimer's disease and Parkinson's disease.","9628149",136]
["zopiclone","zopiclone","C515050","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2012,"22999478","Simultaneous determination of zopiclone and its degradation product and main impurity (2-amino-5-chloropyridine) by micellar liquid chromatography with time-programmed fluorescence detection: preliminary investigation for biological monitoring.","22999478",136]
["zopiclone","zopiclone","C515050","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2013,"24123425","Enantioselective liquid-liquid extraction of zopiclone with mandelic acid ester derivatives.","24123425",136]
["zopiclone","zopiclone","C515050","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"24790062","Quantitative analysis of zopiclone, N-desmethylzopiclone, zopiclone N-oxide and 2-amino-5-chloropyridine in urine using LC-MS-MS.","24790062",136]
["zopiclone","zopiclone","C515050","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2016,"26992521","Coatings of molecularly imprinted polymers based on polyhedral oligomeric silsesquioxane for open tubular capillary electrochromatography.","26992521",136]
["zopiclone","zopiclone","C515050","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1989,"2778667","Acid catalyzed hydrolysis of a series of zopiclone analogues.","2778667",136]
["zopiclone","zopiclone","C515050","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1994,"7952118","Stereospecific high-performance liquid chromatographic assay of zopiclone in human plasma.","7952118",136]
["zopiclone N-oxide","zopiclone N-oxide","C053228","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"24790062","Quantitative analysis of zopiclone, N-desmethylzopiclone, zopiclone N-oxide and 2-amino-5-chloropyridine in urine using LC-MS-MS.","24790062",136]
["zopolrestat","zopolrestat","C067172","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"26512879","Zopolrestat Induced Suicidal Death of Human Erythrocytes.","26512879",136]
["zopolrestat","zopolrestat","C067172","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1997,"9000707","Aldose reductase inhibition protects diabetic and nondiabetic rat hearts from ischemic injury.","9000707",136]
["zopolrestat","zopolrestat","C067172","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1998,"9688914","Metabolic effects of aldose reductase inhibition during low-flow ischemia and reperfusion.","9688914",136]
["zopolrestat","zopolrestat","C067172","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,2,2005,"16048249","Effects of inhibition of the polyol pathway during chronic peritoneal exposure to a dialysis solution.","16048249",136]
["zorubicin","zorubicin","C002205","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1996,"8807544","Stability and compatibility studies of zorubicin in intravenous fluids and PVC infusion bags.","8807544",136]
["zosuquidar trihydrochloride","zosuquidar trihydrochloride","C095179","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,1999,"10374882","Growth inhibition, cytokinesis failure and apoptosis of multidrug-resistant leukemia cells after treatment with P-glycoprotein inhibitory agents.","10374882",136]
["zotarolimus","zotarolimus","C489443","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22561362","Comparative assessment of transient exposure of paclitaxel or zotarolimus on in vitro vascular cell death, proliferation, migration, and proinflammatory biomarker expression.","22561362",136]
["zotarolimus","zotarolimus","C489443","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22959701","Endothelial progenitor cell response to antiproliferative drug exposure.","22959701",136]
["zotarolimus","zotarolimus","C489443","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2013,"23449430","Metformin impairs vascular endothelial recovery after stent placement in the setting of locally eluted mammalian target of rapamycin inhibitors via S6 kinase-dependent inhibition of cell proliferation.","23449430",136]
["zotarolimus","zotarolimus","C489443","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2007,"17438408","Zotarolimus, a novel sirolimus analogue with potent anti-proliferative activity on coronary smooth muscle cells and reduced potential for systemic immunosuppression.","17438408",136]
["zotarolimus","zotarolimus","C489443","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"19786265","Comparative analysis of neointimal coverage with paclitaxel and zotarolimus drug-eluting stents, using optical coherence tomography 6 months after implantation.","19786265",136]
["zotarolimus","zotarolimus","C489443","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"21030718","Cellular and molecular changes associated with inhibitory effect of pioglitazone on neointimal growth in patients with type 2 diabetes after zotarolimus-eluting stent implantation.","21030718",136]
["zotarolimus","zotarolimus","C489443","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2010,"21087758","Neovascular microchannels in sirolimus-eluting stent occlusion at late phase.","21087758",136]
["zotarolimus","zotarolimus","C489443","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21468534","Clinical outcomes by geographic region for patients implanted with the zotarolimus-eluting stent.","21468534",136]
["zotarolimus","zotarolimus","C489443","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2011,"21586691","Impact of polymer formulations on neointimal proliferation after zotarolimus-eluting stent with different polymers: insights from the RESOLUTE trial.","21586691",136]
["zotarolimus","zotarolimus","C489443","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22561362","Comparative assessment of transient exposure of paclitaxel or zotarolimus on in vitro vascular cell death, proliferation, migration, and proinflammatory biomarker expression.","22561362",136]
["zotarolimus","zotarolimus","C489443","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22959701","Endothelial progenitor cell response to antiproliferative drug exposure.","22959701",136]
["zotarolimus","zotarolimus","C489443","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23449430","Metformin impairs vascular endothelial recovery after stent placement in the setting of locally eluted mammalian target of rapamycin inhibitors via S6 kinase-dependent inhibition of cell proliferation.","23449430",136]
["zotarolimus","zotarolimus","C489443","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2009,"20031706","Frequency and clinical consequences associated with sidebranch occlusion during stent implantation using zotarolimus-eluting and paclitaxel-eluting coronary stents.","20031706",136]
["zotarolimus","zotarolimus","C489443","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,2012,"22561362","Comparative assessment of transient exposure of paclitaxel or zotarolimus on in vitro vascular cell death, proliferation, migration, and proinflammatory biomarker expression.","22561362",136]
["Zoxazolamine","Zoxazolamine","D015049","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1976,"10855","A highly sensitive radiometric assay for zoxazolamine hydroxylation by liver microsomal cytochrome P-450 and P-448: properties of the membrane-bound and purified reconstituted system.","10855",136]
["Zoxazolamine","Zoxazolamine","D015049","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1968,"5638660","The renal handling of zoxazolamine (flexin).","5638660",136]
["Zoxazolamine","Zoxazolamine","D015049","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,2,1961,"13690995","Death due to hepatic necrosis in a patient receiving zoxazolamine. Report of a case and review of the literature.","13690995",136]
["ZP-CT-A compound","ZP-CT-A compound","C512934","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2006,"16794323","Polyphenolic constituent structures of Zanthoxylum piperitum fruit and the antibacterial effects of its polymeric procyanidin on methicillin-resistant Staphylococcus aureus.","16794323",136]
["ZR 2003","ZR 2003","C570100","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"21764236","A bioanalytical investigation on the exquisitely strong in vitro potency of the EGFR-DNA targeting type II combi-molecule ZR2003 and its mitigated in vivo antitumour activity.","21764236",136]
["ZR 2003","ZR 2003","C570100","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21764236","A bioanalytical investigation on the exquisitely strong in vitro potency of the EGFR-DNA targeting type II combi-molecule ZR2003 and its mitigated in vivo antitumour activity.","21764236",136]
["ZR 2003","ZR 2003","C570100","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2015,"25092264","Positional isomerization of a non-cleavable combi-molecule dramatically altered tumor cell response profile.","25092264",136]
["ZR2002","ZR2002","C493478","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2004,"15382076","Multiple mechanisms of action of ZR2002 in human breast cancer cells: a novel combi-molecule designed to block signaling mediated by the ERB family of oncogenes and to damage genomic DNA.","15382076",136]
["ZR2002","ZR2002","C493478","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2004,"15382076","Multiple mechanisms of action of ZR2002 in human breast cancer cells: a novel combi-molecule designed to block signaling mediated by the ERB family of oncogenes and to damage genomic DNA.","15382076",136]
["ZRBA1 compound","ZRBA1 compound","C503825","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2005,"15982640","Mechanism of action of a novel \"combi-triazene\" engineered to possess a polar functional group on the alkylating moiety: evidence for enhancement of potency.","15982640",136]
["ZRBA1 compound","ZRBA1 compound","C503825","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2009,"19581798","Interaction of ionizing radiation and ZRBA1, a mixed EGFR/DNA-targeting molecule.","19581798",136]
["ZRBA1 compound","ZRBA1 compound","C503825","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22421369","Enhancement of the cytotoxic potential of the mixed EGFR and DNA-targeting 'combi-molecule' ZRBA1 against human solid tumour cells by a bis-quinazoline-based drug design approach.","22421369",136]
["ZRBA1 compound","ZRBA1 compound","C503825","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2006,"16428934","The combi-targeting concept: evidence for the formation of a novel inhibitor in vivo.","16428934",136]
["ZRBA1 compound","ZRBA1 compound","C503825","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22421369","Enhancement of the cytotoxic potential of the mixed EGFR and DNA-targeting 'combi-molecule' ZRBA1 against human solid tumour cells by a bis-quinazoline-based drug design approach.","22421369",136]
["ZRF4 compound","ZRF4 compound","C562198","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21647162","ZRF4, a combi-molecule with increased efficacy as compared with the individual components in chronic lymphocytic leukemia lymphocytes in vitro.","21647162",136]
["ZS-9 compound","ZS-9 compound","C000597310","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"25531770","Characterization of structure and function of ZS-9, a K+ selective ion trap.","25531770",136]
["ZSM-5 zeolite","ZSM-5 zeolite","C570564","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2014,"24123971","Hydrothermal fabrication of ZSM-5 zeolites: biocompatibility, drug delivery property, and bactericidal property.","24123971",136]
["ZSM-5 zeolite","ZSM-5 zeolite","C570564","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2011,"22052456","The porosity, acidity, and reactivity of dealuminated zeolite ZSM-5 at the single particle level: the influence of the zeolite architecture.","22052456",136]
["ZSM-5 zeolite","ZSM-5 zeolite","C570564","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2015,"26336806","Porosity-Acidity Interplay in Hierarchical ZSM-5 Zeolites for Pyrolysis Oil Valorization to Aromatics.","26336806",136]
["ZSTK474","ZSTK474","C510150","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2006,"16622124","Antitumor activity of ZSTK474, a new phosphatidylinositol 3-kinase inhibitor.","16622124",136]
["ZSTK474","ZSTK474","C510150","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2009,"19094964","Inhibition of PI3K by ZSTK474 suppressed tumor growth not via apoptosis but G0/G1 arrest.","19094964",136]
["ZSTK474","ZSTK474","C510150","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2009,"19372588","Targeting melanoma with dual phosphoinositide 3-kinase/mammalian target of rapamycin inhibitors.","19372588",136]
["ZSTK474","ZSTK474","C510150","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22088482","ZSTK474, a specific phosphatidylinositol 3-kinase inhibitor, induces G1 arrest of the cell cycle in vivo.","22088482",136]
["ZSTK474","ZSTK474","C510150","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2013,"24204196","Combination of the PI3K inhibitor ZSTK474 with a PSMA-targeted immunotoxin accelerates apoptosis and regression of prostate cancer.","24204196",136]
["ZSTK474","ZSTK474","C510150","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"24297065","Dual targeting of glioblastoma multiforme with a proteasome inhibitor (Velcade) and a phosphatidylinositol 3-kinase inhibitor (ZSTK474).","24297065",136]
["ZSTK474","ZSTK474","C510150","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"26081844","Synergistic antitumour activity of RAF265 and ZSTK474 on human TT medullary thyroid cancer cells.","26081844",136]
["ZSTK474","ZSTK474","C510150","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"27194941","In Vitro Antileukemia Activity of ZSTK474 on K562 and Multidrug Resistant K562/A02 Cells.","27194941",136]
["ZSTK474","ZSTK474","C510150","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2006,"16622124","Antitumor activity of ZSTK474, a new phosphatidylinositol 3-kinase inhibitor.","16622124",136]
["ZSTK474","ZSTK474","C510150","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2009,"19094964","Inhibition of PI3K by ZSTK474 suppressed tumor growth not via apoptosis but G0/G1 arrest.","19094964",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C343875,B343875)","v":"ZSTK474"},"ZSTK474","C510150","3_KE",870,3,"Cell Proliferation","Increase",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J343875,K343875)","v":"Cell Proliferation"},"D049109","Cell Proliferation",1,2,2009,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q343875,Q343875)","v":"19372588"},"Targeting melanoma with dual phosphoinositide 3-kinase/mammalian target of rapamycin inhibitors.","19372588",136]
["ZSTK474","ZSTK474","C510150","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21352422","Effectiveness of combined treatment using X-rays and a phosphoinositide 3-kinase inhibitor, ZSTK474, on proliferation of HeLa cells in vitro and in vivo.","21352422",136]
["ZSTK474","ZSTK474","C510150","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21882832","Synthesis and biological evaluation of novel analogues of the pan class I phosphatidylinositol 3-kinase (PI3K) inhibitor 2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474).","21882832",136]
["ZSTK474","ZSTK474","C510150","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"21993922","ZSTK474, a PI3K inhibitor, suppresses proliferation and sensitizes human             pancreatic adenocarcinoma cells to gemcitabine.","21993922",136]
["ZSTK474","ZSTK474","C510150","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"22349137","Inhibitory effects of ZSTK474, a phosphatidylinositol 3-kinase inhibitor, on adjuvant-induced arthritis in rats.","22349137",136]
["ZSTK474","ZSTK474","C510150","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"23644197","Synthesis and biological evaluation of novel phosphatidylinositol 3-kinase inhibitors: Solubilized 4-substituted benzimidazole analogs of 2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474).","23644197",136]
["ZSTK474","ZSTK474","C510150","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"24022196","Targeting EGFR and PI3K pathways in ovarian cancer.","24022196",136]
["ZSTK474","ZSTK474","C510150","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24297065","Dual targeting of glioblastoma multiforme with a proteasome inhibitor (Velcade) and a phosphatidylinositol 3-kinase inhibitor (ZSTK474).","24297065",136]
["ZSTK474","ZSTK474","C510150","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"26918351","ZSTK474, a specific class I phosphatidylinositol 3-kinase inhibitor, induces G1 arrest and autophagy in human breast cancer MCF-7 cells.","26918351",136]
["ZSTK474","ZSTK474","C510150","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27194941","In Vitro Antileukemia Activity of ZSTK474 on K562 and Multidrug Resistant K562/A02 Cells.","27194941",136]
["ZSTK474","ZSTK474","C510150","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28388564","Antiproliferative effect of ZSTK474 alone or in combination with chemotherapeutic drugs on HL60 and HL60/ADR cells.","28388564",136]
["ZSTK474","ZSTK474","C510150","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28912036","Dual effects of the PI3K inhibitor ZSTK474 on multidrug efflux pumps in resistant cancer cells.","28912036",136]
["ZSTK474","ZSTK474","C510150","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2009,"19144509","Antiangiogenic effect of ZSTK474, a novel phosphatidylinositol 3-kinase inhibitor.","19144509",136]
["ZSTK474","ZSTK474","C510150","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2013,"23812078","In vitro antimetastatic effect of phosphatidylinositol 3-kinase inhibitor ZSTK474 on prostate cancer PC3 cells.","23812078",136]
["ZT-25 compound","ZT-25 compound","C000611678","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2016,"26689625","ZT-25, a new vacuolar H(+)-ATPase inhibitor, induces apoptosis and protective autophagy through ROS generation in HepG2 cells.","26689625",136]
["zuogui","zuogui","C552040","3_KE",870,3,"Cell Proliferation","Increase","Airway Remodeling","D056151","Airway Remodeling",2,3,2017,"29071866","[Antiasthmatic effects of different tonifying kidney-Yin formulas and their effects on airway remodeling in chronic asthma].","29071866",136]
["zuogui","zuogui","C552040","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20462049","[Effects of drug-contained sera of naoluo xintong and zuogui pill on the proliferation and differentiation of in vitro cultured neural stem cells in rats].","20462049",136]
["zuojin","zuojin","C545320","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2015,"25847773","Extract of Zuojin Pill ([characters: see text]) induces apoptosis of SGC-7901 cells via mitochondria-dependent pathway.","25847773",136]
["Zuo-Jin-Wan","Zuo-Jin-Wan","C560510","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2014,"25085593","Zuo Jin Wan reverses P-gp-mediated drug-resistance by inhibiting activation of the PI3K/Akt/NF-κB pathway.","25085593",136]
["Zuo-Jin-Wan","Zuo-Jin-Wan","C560510","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"29183322","Extracts of Zuo Jin Wan, a traditional Chinese medicine, phenocopies 5-HTR1D antagonist in attenuating Wnt/β-catenin signaling in colorectal cancer cells.","29183322",136]
["zwittergent 3-12","zwittergent 3-12","C034730","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2005,"16395913","[Study on BS-12 as a new probe for the determination of DNA by resonance light scattering].","16395913",136]
["zwittergent 3-12","zwittergent 3-12","C034730","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2007,"17266966","Micellar liquid chromatography with dodecyl dimethyl betaine as an in vitro method for prediction of protein-drug binding.","17266966",136]
["zwittergent 3-12","zwittergent 3-12","C034730","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2014,"25244843","[Effect of SDS on the adsorption of Cd2+ onto amphoteric modified bentonites].","25244843",136]
["zwittergent 3-12","zwittergent 3-12","C034730","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1984,"6490786","Solubilization of plasma membranes in anionic, non-ionic and zwitterionic surfactants for iso-dalt analysis: a critical evaluation.","6490786",136]
["ZXHA-TC compound","ZXHA-TC compound","C000622577","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2016,"27017891","Chondro-Protective and Antiarthritic Effects of Sulfonamido-Based Gallate-ZXHA-TC in Vitro and in Vivo.","27017891",136]
["ZY-1 compound","ZY-1 compound","C000588574","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2013,"24057433","ZY-1, a novel nicotinic analog, promotes proliferation and migration of adult hippocampal neural stem/progenitor cells.","24057433",136]
["ZYD88 herbal formula","ZYD88 herbal formula","C483847","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2003,"12883751","The Chinese medicinal herbal formula ZYD88 inhibits cell growth and promotes cell apoptosis in prostatic tumor cells.","12883751",136]
["ZYD88 herbal formula","ZYD88 herbal formula","C483847","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2007,"17487396","Inhibition of tumor growth and tumor metastasis by a Chinese herbal formula--ZYD88, in an animal model with metastatic Lewis lung carcinoma.","17487396",136]
["ZYD88 herbal formula","ZYD88 herbal formula","C483847","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2007,"17487396","Inhibition of tumor growth and tumor metastasis by a Chinese herbal formula--ZYD88, in an animal model with metastatic Lewis lung carcinoma.","17487396",136]
["Zyflamend","Zyflamend","C519312","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2007,"17218785","Zyflamend-mediated inhibition of human prostate cancer PC3 cell proliferation: effects on 12-LOX and Rb protein phosphorylation.","17218785",136]
["Zyflamend","Zyflamend","C519312","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2007,"17516865","Zyflamend, a polyherbal preparation, inhibits invasion, suppresses osteoclastogenesis, and potentiates apoptosis through down-regulation of NF-kappa B activation and NF-kappa B-regulated gene products.","17516865",136]
["Zyflamend","Zyflamend","C519312","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"21745040","Zyflamend mediates therapeutic induction of autophagy to apoptosis in melanoma cells.","21745040",136]
["Zyflamend","Zyflamend","C519312","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"21935918","Zyflamend suppresses growth and sensitizes human pancreatic tumors to gemcitabine in an orthotopic mouse model through modulation of multiple targets.","21935918",136]
["Zyflamend","Zyflamend","C519312","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2012,"22004570","Zyflamend sensitizes tumor cells to TRAIL-induced apoptosis through up-regulation of death receptors and down-regulation of survival proteins: role of ROS-dependent CCAAT/enhancer-binding protein-homologous protein pathway.","22004570",136]
["Zyflamend","Zyflamend","C519312","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2007,"17218785","Zyflamend-mediated inhibition of human prostate cancer PC3 cell proliferation: effects on 12-LOX and Rb protein phosphorylation.","17218785",136]
["Zyflamend","Zyflamend","C519312","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2008,"18687669","Zyflamend reduces LTB4 formation and prevents oral carcinogenesis in a 7,12-dimethylbenz[alpha]anthracene (DMBA)-induced hamster cheek pouch model.","18687669",136]
["Zyflamend","Zyflamend","C519312","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"21656835","Zyflamend inhibits the expression and function of androgen receptor and acts synergistically with bicalutimide to inhibit prostate cancer cell growth.","21656835",136]
["Zyflamend","Zyflamend","C519312","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"21745040","Zyflamend mediates therapeutic induction of autophagy to apoptosis in melanoma cells.","21745040",136]
["Zyflamend","Zyflamend","C519312","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2012,"21935918","Zyflamend suppresses growth and sensitizes human pancreatic tumors to gemcitabine in an orthotopic mouse model through modulation of multiple targets.","21935918",136]
["Zyflamend","Zyflamend","C519312","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2011,"21958043","Zyflamend reduces the expression of androgen receptor in a model of castrate-resistant prostate cancer.","21958043",136]
["Zyflamend","Zyflamend","C519312","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2014,"24555771","Zyflamend, a polyherbal mixture, down regulates class I and class II histone deacetylases and increases p21 levels in castrate-resistant prostate cancer cells.","24555771",136]
["Zyflamend","Zyflamend","C519312","6_KE",876,6,"Mutations in Critical Genes","Increase","Mutagenesis","D016296","Mutagenesis",1,1,2012,"22374940","Carnosol, a constituent of Zyflamend, inhibits aryl hydrocarbon receptor-mediated activation of CYP1A1 and CYP1B1 transcription and mutagenesis.","22374940",136]
["Zymosan","Zymosan","D015054","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2011,"21349270","Glutamine treatment attenuates the development of organ injury induced by zymosan administration in mice.","21349270",136]
["Zymosan","Zymosan","D015054","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,1,2016,"26913605","Attenuation of the programmed cell death-1 pathway increases the M1 polarization of macrophages induced by zymosan.","26913605",136]
["Zymosan","Zymosan","D015054","5_KE",768,5,"Cytotoxicity","Increase","Apoptosis","D017209","Apoptosis",1,2,2017,"28922655","Zymosan-a Protects the Hematopoietic System from Radiation-Induced Damage by Targeting TLR2 Signaling Pathway.","28922655",136]
["Zymosan","Zymosan","D015054","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2006,"16543948","Yeast zymosan, a stimulus for TLR2 and dectin-1, induces regulatory antigen-presenting cells and immunological tolerance.","16543948",136]
["Zymosan","Zymosan","D015054","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2006,"16864404","Pulmonary exposure to 1 --&gt; 3-beta-glucan alters adaptive immune responses in rats.","16864404",136]
["Zymosan","Zymosan","D015054","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2010,"20675590","Roles for TGF-beta and programmed cell death 1 ligand 1 in regulatory T cell expansion and diabetes suppression by zymosan in nonobese diabetic mice.","20675590",136]
["Zymosan","Zymosan","D015054","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2011,"22195461","Morphine-modulated mast cell migration and proliferation during early stages of zymosan-induced peritonitis in CBA mice.","22195461",136]
["Zymosan","Zymosan","D015054","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2013,"23633661","Pretreatment with TLR2 and TLR4 ligand modulates innate immunity in corneal fibroblasts challenged with Aspergillus fumigatus.","23633661",136]
["Zymosan","Zymosan","D015054","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,2,2017,"28608139","Doxorubicin Hydrochloride Loaded Zymosan-Polyethylenimine Biopolymeric Nanoparticles for Dual 'Chemoimmunotherapeutic' Intervention in Breast Cancer.","28608139",136]
["Zymosan","Zymosan","D015054","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1999,"10065529","Acidification of the phagosome in Crassostrea virginica hemocytes following engulfment of zymosan.","10065529",136]
["Zymosan","Zymosan","D015054","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1999,"10430174","Herbimycin A inhibits both dephosphorylation and translocation of cofilin induced by opsonized zymosan in macrophagelike U937 cells.","10430174",136]
["Zymosan","Zymosan","D015054","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1992,"1512533","Transfer of zymosan (yeast cell walls) to the parasitophorous vacuoles of macrophages infected with Leishmania amazonensis.","1512533",136]
["Zymosan","Zymosan","D015054","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2005,"15989798","[Relationship between glomerular lesion and NF-kappaB p65 activity in rat multiple organ failure caused by zymosan].","15989798",136]
["Zymosan","Zymosan","D015054","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2006,"16326112","Cloning and characterisation of a serine proteinase from the haemocytes of mud crab Scylla serrata.","16326112",136]
["Zymosan","Zymosan","D015054","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1990,"2122642","Extracellular phospholipase A2 activity in two in vivo models of inflammation.","2122642",136]
["Zymosan","Zymosan","D015054","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1990,"2239443","Cellular and extracellular phospholipase A2 activity in zymosan pleurisy in rat.","2239443",136]
["Zymosan","Zymosan","D015054","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2013,"24369446","A subanesthetic dose of isoflurane during postconditioning ameliorates zymosan-induced neutrophil inflammation lung injury and mortality in mice.","24369446",136]
["Zymosan","Zymosan","D015054","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1989,"2736288","[Lipid peroxidation reactions to the administration of various doses of zymosan].","2736288",136]
["Zymosan","Zymosan","D015054","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1979,"38283","Evidence for an ester linkage between the labile binding site of C3b and receptive surfaces.","38283",136]
["Zymosan","Zymosan","D015054","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1985,"4044589","Effect of divalent metal ions and pH upon the binding reactivity of human serum amyloid P component, a C-reactive protein homologue, for zymosan. Preferential reactivity in the presence of copper and acidic pH.","4044589",136]
["Zymosan","Zymosan","D015054","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1965,"5886150","Role of properdin, O degree factor, polyinosinic acid, and thrombin in the haemolysis of paroxysmal nocturnal haemoglobinuria erythrocytes.","5886150",136]
["Zymosan","Zymosan","D015054","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,1983,"6856384","Studies on human milk macrophages: effect of activation on phagocytosis and secretion of prostaglandin E2 and lysozyme.","6856384",136]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C343939,B343939)","v":"Zymosan"},"Zymosan","D015054","1_MIE",867,1,"Intracellular pH","Decrease",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J343939,K343939)","v":"Hydrogen-Ion Concentration"},"D006863","Hydrogen-Ion Concentration",2,2,1995,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q343939,Q343939)","v":"7561526"},"Protein kinase C and intracellular pH regulate zymosan-induced lysosomal enzyme secretion in macrophages.","7561526",136]
["Zymosan","Zymosan","D015054","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,1973,"4768257","[Serum seromucoid levels in patients with neoplasms and in cases of radiation-induced necrosis following non-specific stimulation with zymosan].","4768257",136]
["Zymosan","Zymosan","D015054","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,1969,"5370339","[A case of delayed post-irradiation ulceration cured by nonspecific stimulation of the organism].","5370339",136]
["Zymosan","Zymosan","D015054","2_KE",868,2,"Tissue Degeneration, Necrosis & Atrophy","Increase","Necrosis","D009336","Necrosis",1,1,1997,"9611293","Kupffer cell activation with BCG. Corynebacterium parvum or zymosan protects against acute liver injury induced by carbon tetrachloride in rats.","9611293",136]
["Zymosan","Zymosan","D015054","4_KE",869,4,"Respiratory or Squamous Metaplasia","Increase","Neovascularization, Pathologic","D009389","Neovascularization, Pathologic",1,1,2009,"19553534","Zymosan, but not lipopolysaccharide, triggers severe and progressive peritoneal injury accompanied by complement activation in a rat peritonitis model.","19553534",136]
["zymosterol","zymosterol","C015582","3_KE",870,3,"Cell Proliferation","Increase","Cell Proliferation","D049109","Cell Proliferation",1,1,2005,"16120615","Characterizing sterol defect suppressors uncovers a novel transcriptional signaling pathway regulating zymosterol biosynthesis.","16120615",136]
["zymosterol","zymosterol","C015582","1_MIE",867,1,"Intracellular pH","Decrease","Hydrogen-Ion Concentration","D006863","Hydrogen-Ion Concentration",2,2,2002,"12010494","The Pneumocystis carinii drug target S-adenosyl-L-methionine:sterol C-24 methyl transferase has a unique substrate preference.","12010494",136]
[null,"Ozone","D010126","7_AO",872,7,"Site of Contact Nasal Tumors","Increase",null,"D009296","Nasal Cavity",1,2,1999,"9949357","Ozone effects on the immediate-phase response to allergen in the nasal airways of allergic asthmatic subjects.","9949357",136]