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{"sheet":"Overview","index":0,"n_rows":268,"n_cols":6,"rows_kept":268,"cut":false,"hidden":false,"merged":[]}
["Overview - AOP ",null,null,{"$f":"(HYPERLINK(\"https://aopwiki.org/aops/193\",\"aop193\"))","v":"aop193"}]
["DUOX inhib alters metamorphosis"]
["MeSH Chemical Name (hyperlinked)","ChemName","chemuid","1_MIE","2_KE","6_AO"]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C4,B4)","v":"Atrazine"},"Atrazine","D001280",0,0,100]
["Propylthiouracil","Propylthiouracil","D011441",0,24,48]
["Water","Water","D014867",0,0,48]
["Triclosan","Triclosan","D014260",0,7,40]
["Carbaryl","Carbaryl","D012721",0,0,38]
["Malathion","Malathion","D008294",0,0,34]
["Serotonin","Serotonin","D012701",0,2,34]
["bisphenol A","bisphenol A","C006780",0,0,32]
["Urea","Urea","D014508",0,0,32]
["Chlorpyrifos","Chlorpyrifos","D004390",0,0,30]
["Endosulfan","Endosulfan","D004726",0,0,29]
["Thiourea","Thiourea","D013890",0,7,26]
["Dexamethasone","Dexamethasone","D003907",0,0,24]
["Sodium Chloride","Sodium Chloride","D012965",0,2,24]
["Taurine","Taurine","D013654",0,1,20]
["4-tert-octylphenol","4-tert-octylphenol","C105260",0,4,16]
["tetrabromobisphenol A","tetrabromobisphenol A","C020806",0,2,16]
["Tretinoin","Tretinoin","D014212",4,1,16]
["Chlorodiphenyl (54% Chlorine)","Chlorodiphenyl (54% Chlorine)","D020111",0,0,15]
["Vitamin A","Vitamin A","D014801",0,2,15]
["ammonium perchlorate","ammonium perchlorate","C053506",0,4,14]
["Blood Glucose","Blood Glucose","D001786",0,1,14]
["perchlorate","perchlorate","C494474",0,13,14]
["Reserpine","Reserpine","D012110",0,0,14]
["sodium perchlorate","sodium perchlorate","C031068",0,3,14]
["Trenbolone Acetate","Trenbolone Acetate","D014204",0,2,14]
["Materia Medica","Materia Medica","D008419",0,0,13]
["acetochlor","acetochlor","C043377",0,0,12]
["Industrial Waste","Industrial Waste","D007220",0,0,12]
["Liver Glycogen","Liver Glycogen","D008112",0,0,12]
["nonylphenol","nonylphenol","C025256",0,0,12]
["Ascorbic Acid","Ascorbic Acid","D001205",0,0,11]
["Norepinephrine","Norepinephrine","D009638",0,0,11]
["Dopamine","Dopamine","D004298",0,0,10]
["perfluorooctane sulfonic acid","perfluorooctane sulfonic acid","C076994",0,4,10]
["2,2',4,4'-tetrabromodiphenyl ether","2,2',4,4'-tetrabromodiphenyl ether","C511295",0,4,8]
["Amiloride","Amiloride","D000584",0,1,8]
["Ammonia","Ammonia","D000641",0,0,8]
["Cholesterol","Cholesterol","D002784",0,0,8]
["Coal","Coal","D003031",0,0,8]
["Cyclophosphamide","Cyclophosphamide","D003520",0,0,8]
["cypermethrin","cypermethrin","C017160",0,0,8]
["Dimethyl Sulfoxide","Dimethyl Sulfoxide","D004121",0,0,8]
["Ethanol","Ethanol","D000431",0,1,8]
["Ethylenethiourea","Ethylenethiourea","D005031",0,5,8]
["Fluoxetine","Fluoxetine","D005473",0,2,8]
["Methimazole","Methimazole","D008713",0,8,8]
["Tetrodotoxin","Tetrodotoxin","D013779",0,0,8]
["tributyltin","tributyltin","C011559",0,2,8]
["Trinitrotoluene","Trinitrotoluene","D014303",0,0,8]
["triphenyltin","triphenyltin","C030665",0,0,8]
["Acetylcholine","Acetylcholine","D000109",0,0,7]
["Carbon Dioxide","Carbon Dioxide","D002245",0,0,7]
["Chloramphenicol","Chloramphenicol","D002701",0,0,7]
["Glucose","Glucose","D005947",0,0,7]
["2,2',4,4',5-brominated diphenyl ether","2,2',4,4',5-brominated diphenyl ether","C477694",0,2,6]
["2,4-dinitrotoluene","2,4-dinitrotoluene","C016403",0,0,6]
["3,4,5,3',4'-pentachlorobiphenyl","3,4,5,3',4'-pentachlorobiphenyl","C023035",0,0,6]
["clophen A50","clophen A50","C025647",0,0,6]
["Coal Tar","Coal Tar","D003033",0,0,6]
["Epinephrine","Epinephrine","D004837",0,3,6]
["Fadrozole","Fadrozole","D017316",0,0,6]
["galaxolide","galaxolide","C033119",0,2,6]
["Glycogen","Glycogen","D006003",0,0,6]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C68,B68)","v":"Mifepristone"},"Mifepristone","D015735",0,0,6]
["Nitric Oxide","Nitric Oxide","D009569",2,0,6]
["Orotic Acid","Orotic Acid","D009963",0,0,6]
["potassium perchlorate","potassium perchlorate","C009006",0,4,6]
["pterorhodin","pterorhodin","C017688",0,0,6]
["pyrachlostrobin","pyrachlostrobin","C513428",0,0,6]
["Quilt","Quilt","C000597676",0,0,6]
["sodium nitrate","sodium nitrate","C031618",0,2,6]
["Stratego","Stratego","C556296",0,0,6]
["Thalidomide","Thalidomide","D013792",0,0,6]
["Uracil","Uracil","D014498",0,1,6]
["Vitamin B 12","Vitamin B 12","D014805",0,0,6]
["4-octylphenol","4-octylphenol","C080417",0,0,5]
["Carbon Tetrachloride","Carbon Tetrachloride","D002251",0,0,5]
["DDT","DDT","D003634",0,0,5]
["(4-(4-hydroxy-3-isopropyl-5-(4-nitrophenylethynyl)benzyl)-3,5-dimethylphenoxy)acetic acid","(4-(4-hydroxy-3-isopropyl-5-(4-nitrophenylethynyl)benzyl)-3,5-dimethylphenoxy)acetic acid","C461658",0,2,4]
["1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane","1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane","C517232",0,0,4]
["2,2',4,4'-tetrahydroxybenzophenone","2,2',4,4'-tetrahydroxybenzophenone","C035476",0,2,4]
["2,4-Dichlorophenoxyacetic Acid","2,4-Dichlorophenoxyacetic Acid","D015084",0,0,4]
["2,6-dinitrotoluene","2,6-dinitrotoluene","C023514",0,0,4]
["2-hydroxysaclofen","2-hydroxysaclofen","C057491",0,0,4]
["3-nitro-1,2,4-triazol-5-one","3-nitro-1,2,4-triazol-5-one","C505897",0,0,4]
["5-(3,5-diiodo-4-(3-isopropyl-4-hydroxyphenoxy)benzyl)imidazolidine-2,4-dione","5-(3,5-diiodo-4-(3-isopropyl-4-hydroxyphenoxy)benzyl)imidazolidine-2,4-dione","C517607",0,0,4]
["Acetylcarnitine","Acetylcarnitine","D000108",0,0,4]
["Aminopropionitrile","Aminopropionitrile","D000629",0,0,4]
["amtizol","amtizol","C044365",0,0,4]
["azocyclotin","azocyclotin","C000613986",0,0,4]
["Baclofen","Baclofen","D001418",0,0,4]
["benthiocarb","benthiocarb","C037925",0,0,4]
["Bromocriptine","Bromocriptine","D001971",0,0,4]
["butachlor","butachlor","C054409",0,2,4]
["Camphor","Camphor","D002164",0,0,4]
["captax","captax","C005563",0,0,4]
["Chlortetracycline","Chlortetracycline","D002751",0,0,4]
["Coal Ash","Coal Ash","D060729",0,0,4]
["Cycloheximide","Cycloheximide","D003513",0,0,4]
["Cyproterone Acetate","Cyproterone Acetate","D017373",0,0,4]
["decabromobiphenyl ether","decabromobiphenyl ether","C010902",0,2,4]
["Dichlorodiphenyl Dichloroethylene","Dichlorodiphenyl Dichloroethylene","D003633",0,0,4]
["Diethylhexyl Phthalate","Diethylhexyl Phthalate","D004051",0,2,4]
["Diltiazem","Diltiazem","D004110",0,0,4]
["enzacamene","enzacamene","C038939",0,0,4]
["ergocornine","ergocornine","C100271",0,0,4]
["ergotoxine","ergotoxine","C100272",0,0,4]
["Finasteride","Finasteride","D018120",0,0,4]
["fludioxonil","fludioxonil","C108339",0,0,4]
["Guanylthiourea","Guanylthiourea","D006164",0,0,4]
["Histamine","Histamine","D006632",2,0,4]
["Hydroxypropiophenone","Hydroxypropiophenone","D006910",0,1,4]
["imidacloprid","imidacloprid","C082359",0,0,4]
["Inositol","Inositol","D007294",0,0,4]
["Iproniazid","Iproniazid","D007490",0,0,4]
["Kanamycin","Kanamycin","D007612",0,0,4]
["Levonorgestrel","Levonorgestrel","D016912",0,4,4]
["mefenacet","mefenacet","C425686",0,0,4]
["Mercaptoethanol","Mercaptoethanol","D008623",0,0,4]
["Methoxychlor","Methoxychlor","D008731",0,1,4]
["Methylthiouracil","Methylthiouracil","D008779",0,2,4]
["N-(2-guanidinoethyl)-5-isoquinolinesulfonamide","N-(2-guanidinoethyl)-5-isoquinolinesulfonamide","C043204",0,0,4]
["Nicotine","Nicotine","D009538",0,0,4]
["Nitrovin","Nitrovin","D009610",0,0,4]
["Norethindrone","Norethindrone","D009640",0,2,4]
["novaluron","novaluron","C471805",0,0,4]
["Ouabain","Ouabain","D010042",0,0,4]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C132,B132)","v":"pentabromodiphenyl ether"},"pentabromodiphenyl ether","C086401",0,0,4]
["Pentobarbital","Pentobarbital","D010424",0,0,4]
["Permethrin","Permethrin","D026023",0,0,4]
["pyrimethanil","pyrimethanil","C108337",0,0,4]
["roscovitine","roscovitine","C104586",0,0,4]
["Sertraline","Sertraline","D020280",0,0,4]
["Simazine","Simazine","D012839",0,0,4]
["simetryn","simetryn","C033807",0,0,4]
["sodium arsenite","sodium arsenite","C017947",0,0,4]
["Sodium Fluoride","Sodium Fluoride","D012969",0,0,4]
["tebuconazole","tebuconazole","C087114",0,0,4]
["thiamethoxam","thiamethoxam","C416660",0,0,4]
["Thiophanate","Thiophanate","D013875",0,0,4]
["thiosemicarbazide","thiosemicarbazide","C005151",0,0,4]
["Thiouracil","Thiouracil","D013889",0,4,4]
["triadimefon","triadimefon","C032910",0,2,4]
["Trichlorfon","Trichlorfon","D014236",0,0,4]
["triclopyr","triclopyr","C032742",0,0,4]
["Trifluoperazine","Trifluoperazine","D014268",0,0,4]
["Urethane","Urethane","D014520",0,0,4]
["Waste Water","Waste Water","D062065",0,2,4]
["Zinc Oxide","Zinc Oxide","D015034",0,0,4]
["Fluorouracil","Fluorouracil","D005472",0,0,3]
["Hydrogen Peroxide","Hydrogen Peroxide","D006861",56,0,3]
["Methane","Methane","D008697",0,0,3]
["3,4-Dihydroxyphenylacetic Acid","3,4-Dihydroxyphenylacetic Acid","D015102",0,0,2]
["4-hydroxypropiophenone","4-hydroxypropiophenone","C069170",0,1,2]
["5-carboxamidotryptamine","5-carboxamidotryptamine","C047087",0,0,2]
["Acetazolamide","Acetazolamide","D000086",0,0,2]
["acetylcellulose","acetylcellulose","C005062",0,0,2]
["Adenine","Adenine","D000225",0,0,2]
["Aflatoxin B1","Aflatoxin B1","D016604",0,0,2]
["aflatoxin G1","aflatoxin G1","C027955",0,0,2]
["Allopurinol","Allopurinol","D000493",0,0,2]
["Aminopterin","Aminopterin","D000630",0,0,2]
["ammonium nitrate","ammonium nitrate","C006568",0,0,2]
["arbekacin","arbekacin","C031986",0,0,2]
["asphalt","asphalt","C006647",0,0,2]
["Calcium Carbonate","Calcium Carbonate","D002119",0,0,2]
["Calcium, Dietary","Calcium, Dietary","D002136",0,1,2]
["Carbamyl Phosphate","Carbamyl Phosphate","D002221",0,0,2]
["Carbon Monoxide","Carbon Monoxide","D002248",0,0,2]
["Cellulose","Cellulose","D002482",0,0,2]
["Chlorobutanol","Chlorobutanol","D002724",0,0,2]
["Chloroquine","Chloroquine","D002738",0,0,2]
["Chlorpromazine","Chlorpromazine","D002746",0,0,2]
["Choline","Choline","D002794",0,0,2]
["Chondroitin","Chondroitin","D002807",0,0,2]
["Cisplatin","Cisplatin","D002945",0,0,2]
["citreoviridin","citreoviridin","C014416",0,0,2]
["Citric Acid","Citric Acid","D019343",0,0,2]
["Clindamycin","Clindamycin","D002981",0,0,2]
["Cytosine","Cytosine","D003596",0,0,2]
["decamethrin","decamethrin","C017180",0,0,2]
["Dibekacin","Dibekacin","D003982",0,0,2]
["Dinoprostone","Dinoprostone","D015232",0,0,2]
["fenpropimorph","fenpropimorph","C050435",0,0,2]
["Folic Acid","Folic Acid","D005492",0,0,2]
["Galactose","Galactose","D005690",0,0,2]
["GC 1 compound","GC 1 compound","C413355",0,0,2]
["Glutethimide","Glutethimide","D005984",0,0,2]
["Guanine","Guanine","D006147",0,0,2]
["Hyaluronic Acid","Hyaluronic Acid","D006820",0,0,2]
["Ice","Ice","D007053",0,0,2]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C196,B196)","v":"imidazole"},"imidazole","C029899",0,0,2]
["Latex","Latex","D007840",0,0,2]
["Lewis X Antigen","Lewis X Antigen","D016256",0,0,2]
["Lysergic Acid Diethylamide","Lysergic Acid Diethylamide","D008238",0,0,2]
["Melengestrol Acetate","Melengestrol Acetate","D008552",0,0,2]
["Methylcholanthrene","Methylcholanthrene","D008748",0,0,2]
["Methylene Blue","Methylene Blue","D008751",0,0,2]
["Methysergide","Methysergide","D008784",0,0,2]
["monogalactosyldiacylglycerol","monogalactosyldiacylglycerol","C009909",0,0,2]
["monomethyl phthalate","monomethyl phthalate","C517284",0,0,2]
["N-Acetylneuraminic Acid","N-Acetylneuraminic Acid","D019158",0,0,2]
["Nifedipine","Nifedipine","D009543",0,0,2]
["Oleandomycin","Oleandomycin","D009827",0,0,2]
["Oxidopamine","Oxidopamine","D016627",0,0,2]
["Ozone","Ozone","D010126",0,0,2]
["Phenobarbital","Phenobarbital","D010634",0,0,2]
["PKH 26","PKH 26","C070080",0,0,2]
["polysialic acid","polysialic acid","C021319",0,0,2]
["porphyropsin","porphyropsin","C010507",0,0,2]
["propionic acid","propionic acid","C029658",0,0,2]
["Prostaglandins E","Prostaglandins E","D011458",0,0,2]
["pyrimidine","pyrimidine","C030986",0,0,2]
["retinol palmitate","retinol palmitate","C014794",0,0,2]
["Riboflavin","Riboflavin","D012256",0,0,2]
["royal jelly","royal jelly","C058787",0,0,2]
["Ruthenium Red","Ruthenium Red","D012430",0,0,2]
["Sewage","Sewage","D012722",0,0,2]
["Spermine","Spermine","D013096",0,0,2]
["succinonitrile","succinonitrile","C010337",0,0,2]
["Tetracycline","Tetracycline","D013752",0,0,2]
["Theophylline","Theophylline","D013806",0,0,2]
["Thiamine","Thiamine","D013831",0,0,2]
["Toluene","Toluene","D014050",0,0,2]
["Vinblastine","Vinblastine","D014747",0,0,2]
["Vitamin D","Vitamin D","D014807",0,0,2]
["Vitamin E","Vitamin E","D014810",0,0,2]
["Acid Rain","Acid Rain","D015258",0,0,1]
["Chlorpropamide","Chlorpropamide","D002747",0,0,1]
["Demeclocycline","Demeclocycline","D003707",0,0,1]
["entinostat","entinostat","C118739",0,0,1]
["Eugenol","Eugenol","D005054",0,0,1]
["Hydroflumethiazide","Hydroflumethiazide","D006857",0,0,1]
["Methoxyflurane","Methoxyflurane","D008733",0,0,1]
["phosalone","phosalone","C003117",0,0,1]
["Radioactive Fallout","Radioactive Fallout","D011847",0,2,1]
["4-chlorobenzo(f)isoquinoline","4-chlorobenzo(f)isoquinoline","C495450",0,2,0]
["Acrolein","Acrolein","D000171",4,0,0]
["Alloxan","Alloxan","D000496",0,1,0]
["almorexant","almorexant","C519150",2,0,0]
["Colforsin","Colforsin","D005576",2,0,0]
["Dibutyl Phthalate","Dibutyl Phthalate","D003993",0,2,0]
["diphenyleneiodonium","diphenyleneiodonium","C007517",4,0,0]
["fenoxycarb","fenoxycarb","C052034",0,2,0]
["Heme","Heme","D006418",4,0,0]
["Heparin","Heparin","D006493",2,0,0]
["Hypochlorous Acid","Hypochlorous Acid","D006997",4,0,0]
["indium tin oxide","indium tin oxide","C109984",2,0,0]
["iodonium thiophene","iodonium thiophene","C051503",4,0,0]
["Lindane","Lindane","D001556",0,2,0]
["Linuron","Linuron","D008044",0,2,0]
["Mechlorethamine","Mechlorethamine","D008466",2,0,0]
["Mesalamine","Mesalamine","D019804",2,0,0]
["monobutyl phthalate","monobutyl phthalate","C028577",0,2,0]
["Octopamine","Octopamine","D009655",0,1,0]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C260,B260)","v":"oxaliplatin"},"oxaliplatin","C030110",2,0,0]
["Phenylthiourea","Phenylthiourea","D010670",0,2,0]
["Pilocarpine","Pilocarpine","D010862",0,2,0]
["pioglitazone","pioglitazone","C060836",2,0,0]
["poly(3,4-ethylene dioxythiophene)","poly(3,4-ethylene dioxythiophene)","C121383",2,0,0]
["PQQ Cofactor","PQQ Cofactor","D045542",2,0,0]
["Prednisolone","Prednisolone","D011239",0,2,0]
["Pyocyanine","Pyocyanine","D011710",4,0,0]
["Tetradecanoylphorbol Acetate","Tetradecanoylphorbol Acetate","D013755",2,0,0]

{"sheet":"Detail","index":1,"n_rows":719,"n_cols":18,"rows_kept":719,"cut":false,"hidden":false,"merged":[]}
["Detail - AOP "]
["Chemical MeSH Name (hyperlinked)","ChemName","chemuid","catord","event_id","event_order","Event Process","Event Action","MeSH term (hyperlinked)","uid","MeSHterm","basescore","Score","Pub Yr","pmid","Title","LinkPMID","aop_id"]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C3,B3)","v":"(4-(4-hydroxy-3-isopropyl-5-(4-nitrophenylethynyl)benzyl)-3,5-dimethylphenoxy)acetic acid"},"(4-(4-hydroxy-3-isopropyl-5-(4-nitrophenylethynyl)benzyl)-3,5-dimethylphenoxy)acetic acid","C461658","6_AO",1101,6,"Amphibian metamorphosis","Altered",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J3,K3)","v":"Metamorphosis, Biological"},"D008675","Metamorphosis, Biological",2,4,2002,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q3,Q3)","v":"12095994"},"A thyroid hormone antagonist that inhibits thyroid hormone action in vivo.","12095994",193]
["(4-(4-hydroxy-3-isopropyl-5-(4-nitrophenylethynyl)benzyl)-3,5-dimethylphenoxy)acetic acid","(4-(4-hydroxy-3-isopropyl-5-(4-nitrophenylethynyl)benzyl)-3,5-dimethylphenoxy)acetic acid","C461658","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,2012,"22968643","Thyroid hormone signaling in the Xenopus laevis embryo is functional and susceptible to endocrine disruption.","22968643",193]
["1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane","1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane","C517232","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2017,"28917944","Tetrabromoethylcyclohexane affects gonadal differentiation and development in the frog Pelophylax nigromaculatus.","28917944",193]
["2,2',4,4',5-brominated diphenyl ether","2,2',4,4',5-brominated diphenyl ether","C477694","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,2007,"17643505","Distribution of BDE-99 and effects on metamorphosis of BDE-99 and -47 after oral exposure in Xenopus tropicalis.","17643505",193]
["2,2',4,4',5-brominated diphenyl ether","2,2',4,4',5-brominated diphenyl ether","C477694","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2007,"17643505","Distribution of BDE-99 and effects on metamorphosis of BDE-99 and -47 after oral exposure in Xenopus tropicalis.","17643505",193]
["2,2',4,4',5-brominated diphenyl ether","2,2',4,4',5-brominated diphenyl ether","C477694","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,2007,"17643505","Distribution of BDE-99 and effects on metamorphosis of BDE-99 and -47 after oral exposure in Xenopus tropicalis.","17643505",193]
["2,2',4,4'-tetrabromodiphenyl ether","2,2',4,4'-tetrabromodiphenyl ether","C511295","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,2007,"17643505","Distribution of BDE-99 and effects on metamorphosis of BDE-99 and -47 after oral exposure in Xenopus tropicalis.","17643505",193]
["2,2',4,4'-tetrabromodiphenyl ether","2,2',4,4'-tetrabromodiphenyl ether","C511295","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,2016,"27838513","Dietary exposure to polybrominated diphenyl ether 47 (BDE-47) inhibits development and alters thyroid hormone-related gene expression in the brain of Xenopus laevis tadpoles.","27838513",193]
["2,2',4,4'-tetrabromodiphenyl ether","2,2',4,4'-tetrabromodiphenyl ether","C511295","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2007,"17643505","Distribution of BDE-99 and effects on metamorphosis of BDE-99 and -47 after oral exposure in Xenopus tropicalis.","17643505",193]
["2,2',4,4'-tetrabromodiphenyl ether","2,2',4,4'-tetrabromodiphenyl ether","C511295","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,2007,"17643505","Distribution of BDE-99 and effects on metamorphosis of BDE-99 and -47 after oral exposure in Xenopus tropicalis.","17643505",193]
["2,2',4,4'-tetrabromodiphenyl ether","2,2',4,4'-tetrabromodiphenyl ether","C511295","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,2016,"27838513","Dietary exposure to polybrominated diphenyl ether 47 (BDE-47) inhibits development and alters thyroid hormone-related gene expression in the brain of Xenopus laevis tadpoles.","27838513",193]
["2,2',4,4'-tetrahydroxybenzophenone","2,2',4,4'-tetrahydroxybenzophenone","C035476","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2016,"27241388","Development of the Larval Amphibian Growth and Development Assay: Effects of benzophenone-2 exposure in Xenopus laevis from embryo to juvenile.","27241388",193]
["2,2',4,4'-tetrahydroxybenzophenone","2,2',4,4'-tetrahydroxybenzophenone","C035476","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,2016,"27241388","Development of the Larval Amphibian Growth and Development Assay: Effects of benzophenone-2 exposure in Xenopus laevis from embryo to juvenile.","27241388",193]
["2,4-Dichlorophenoxyacetic Acid","2,4-Dichlorophenoxyacetic Acid","D015084","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,1976,"1088411","[Chloroderivatives of phenoxyacetic acid as antagonists of thyroid hormones].","1088411",193]
["2,4-dinitrotoluene","2,4-dinitrotoluene","C016403","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,2007,"17137690","Toxicological responses of red-backed salamanders (Plethodon cinereus) to subchronic soil exposures of 2,4-dinitrotoluene.","17137690",193]
["2,4-dinitrotoluene","2,4-dinitrotoluene","C016403","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,2008,"18551238","Acute toxicity of 2,4,6-trinitrotoluene, 2,4-dinitrotoluene, and 2,6-dinitrotoluene in the adult bullfrog (Lithobates catesbeiana).","18551238",193]
["2,4-dinitrotoluene","2,4-dinitrotoluene","C016403","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,2011,"21257201","Effects of chronic 2,4,6,-trinitrotoluene, 2,4-dinitrotoluene, and 2,6-dinitrotoluene exposure on developing bullfrog (Rana catesbeiana) tadpoles.","21257201",193]
["2,6-dinitrotoluene","2,6-dinitrotoluene","C023514","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,2008,"18551238","Acute toxicity of 2,4,6-trinitrotoluene, 2,4-dinitrotoluene, and 2,6-dinitrotoluene in the adult bullfrog (Lithobates catesbeiana).","18551238",193]
["2,6-dinitrotoluene","2,6-dinitrotoluene","C023514","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,2011,"21257201","Effects of chronic 2,4,6,-trinitrotoluene, 2,4-dinitrotoluene, and 2,6-dinitrotoluene exposure on developing bullfrog (Rana catesbeiana) tadpoles.","21257201",193]
["2-hydroxysaclofen","2-hydroxysaclofen","C057491","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2000,"11018769","Developmental disinhibition: turning off inhibition turns on breathing in vertebrates.","11018769",193]
["3,4,5,3',4'-pentachlorobiphenyl","3,4,5,3',4'-pentachlorobiphenyl","C023035","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,2000,"11059850","Effects of oral exposure to polychlorinated biphenyls (PCBs) on the development and metamorphosis of two amphibian species (Xenopus laevis and Rana temporaria).","11059850",193]
["3,4,5,3',4'-pentachlorobiphenyl","3,4,5,3',4'-pentachlorobiphenyl","C023035","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2000,"11059850","Effects of oral exposure to polychlorinated biphenyls (PCBs) on the development and metamorphosis of two amphibian species (Xenopus laevis and Rana temporaria).","11059850",193]
["3,4-Dihydroxyphenylacetic Acid","3,4-Dihydroxyphenylacetic Acid","D015102","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,2001,"11226628","Day/night variations of dopamine ocular content during Xenopus laevis ontogeny.","11226628",193]
["3-nitro-1,2,4-triazol-5-one","3-nitro-1,2,4-triazol-5-one","C505897","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2017,"28801886","Effects of 3-Nitro-1,2,4-triazol-5-one on Survival, Growth and Metamorphosis in the Northern Leopard Frog, Lithobates pipiens.","28801886",193]
["4-chlorobenzo(f)isoquinoline","4-chlorobenzo(f)isoquinoline","C495450","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,2005,"15921678","4-Chlorobenzo[F]isoquinoline (CBIQ), a novel activator of CFTR and DeltaF508 CFTR.","15921678",193]
["4-hydroxypropiophenone","4-hydroxypropiophenone","C069170","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1952,"13031198","[Effect of p-hydroxypropiophenone on natural and experimental metamorphosis in Alytes obstetricans Laur. larvae].","13031198",193]
["4-hydroxypropiophenone","4-hydroxypropiophenone","C069170","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,1,1960,"13718362","Inhibitory effect of para-hydroxypropiophenone on the development of gonad in thyroidectomized frog larvae.","13718362",193]
["4-octylphenol","4-octylphenol","C080417","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,2002,"11882479","Octylphenol and UV-B radiation alter larval development and hypothalamic gene expression in the leopard frog (Rana pipiens).","11882479",193]
["4-octylphenol","4-octylphenol","C080417","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2002,"11882479","Octylphenol and UV-B radiation alter larval development and hypothalamic gene expression in the leopard frog (Rana pipiens).","11882479",193]
["4-tert-octylphenol","4-tert-octylphenol","C105260","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2008,"18080904","Chronic exposure of Rana pipiens tadpoles to UVB radiation and the estrogenic chemical 4-tert-octylphenol.","18080904",193]
["4-tert-octylphenol","4-tert-octylphenol","C105260","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2008,"18396791","Effects of 4-tert-Octylphenol on the incubation of eggs in Japanese brown frogs (Rana japonica).","18396791",193]
["4-tert-octylphenol","4-tert-octylphenol","C105260","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2010,"20821635","Preexposure to ultraviolet B radiation and 4-tert-octylphenol affects the response of Rana pipiens tadpoles to 3,5,3'-triiodothyronine.","20821635",193]
["4-tert-octylphenol","4-tert-octylphenol","C105260","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2016,"27143402","Development of the Larval Amphibian Growth and Development Assay: effects of chronic 4-tert-octylphenol or 17β-trenbolone exposure in Xenopus laevis from embryo to juvenile.","27143402",193]
["4-tert-octylphenol","4-tert-octylphenol","C105260","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,2009,"19811842","Assessment of thyroid system disruption in Rana pipiens tadpoles chronically exposed to UVB radiation and 4-tert-octylphenol.","19811842",193]
["4-tert-octylphenol","4-tert-octylphenol","C105260","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,2016,"27143402","Development of the Larval Amphibian Growth and Development Assay: effects of chronic 4-tert-octylphenol or 17β-trenbolone exposure in Xenopus laevis from embryo to juvenile.","27143402",193]
["5-(3,5-diiodo-4-(3-isopropyl-4-hydroxyphenoxy)benzyl)imidazolidine-2,4-dione","5-(3,5-diiodo-4-(3-isopropyl-4-hydroxyphenoxy)benzyl)imidazolidine-2,4-dione","C517607","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2008,"17988877","Characterization of thyroid hormone receptor alpha (TRalpha)-specific analogs with varying inner- and outer-ring substituents.","17988877",193]
["5-carboxamidotryptamine","5-carboxamidotryptamine","C047087","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1994,"8090792","Modulation of rhythmic swimming activity in post-embryonic Xenopus laevis tadpoles by 5-hydroxytryptamine acting at 5HT1a receptors.","8090792",193]
["Acetazolamide","Acetazolamide","D000086","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,2003,"12571143","Central CO2 chemoreception in developing bullfrogs: anomalous response to acetazolamide.","12571143",193]
["acetochlor","acetochlor","C043377","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,1999,"10341044","Alteration of leopard frog (Rana pipiens) metamorphosis by the herbicide acetochlor.","10341044",193]
["acetochlor","acetochlor","C043377","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2001,"11764152","Detection of environmental endocrine-disruptor effects on gene expression in live Rana catesbeiana tadpoles using a tail fin biopsy technique.","11764152",193]
["acetochlor","acetochlor","C043377","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2002,"12460798","Exposure to the herbicide acetochlor alters thyroid hormone-dependent gene expression and metamorphosis in Xenopus Laevis.","12460798",193]
["Acetylcarnitine","Acetylcarnitine","D000108","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2013,"23489246","Acetyl-L-carnitine suppresses thyroid hormone-induced and spontaneous anuran tadpole tail shortening.","23489246",193]
["acetylcellulose","acetylcellulose","C005062","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1964,"14191912","[SERUM PROTEIN CHANGES FOLLOWING METAMORPHOSIS IN THE URODELOUS AMPHIBIA PLEURODELES WALTLII MICHAH. AND SALAMANDRA SALAMANDRA L. STUDY BY ELECTROPHORESIS ON CELLULOSE ACETATE].","14191912",193]
["Acetylcholine","Acetylcholine","D000109","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,1972,"4665935","Cardiac acetylcholine content of three vertebrates.","4665935",193]
["Acetylcholine","Acetylcholine","D000109","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1987,"3494362","[Innervation and acetylcholine sensitivity of muscle fibers of the tail of the tadpole Rana temporaria].","3494362",193]
["Acetylcholine","Acetylcholine","D000109","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1978,"626896","Ontogeny of ACh and GABA synthesis during development of the Xenopus retina.","626896",193]
["Acetylcholine","Acetylcholine","D000109","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1981,"7328310","[Ontogenesis of the acetylcholine system in the brain of the South African clawed toad (Xenopus laevis Daudin)].","7328310",193]
["Acid Rain","Acid Rain","D015258","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,1992,"1456779","Effects of acute and chronic acidification on three larval amphibians that breed in temporary ponds.","1456779",193]
["Acrolein","Acrolein","D000171","1_MIE",1156,1,"Dual oxidase","Inhibition","Dual Oxidases","D000074623","Dual Oxidases",2,4,2016,"27612966","Acrolein and thiol-reactive electrophiles suppress allergen-induced innate airway epithelial responses by inhibition of DUOX1 and EGFR.","27612966",193]
["Adenine","Adenine","D000225","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1964,"14209954","URACIL METABOLISM IN TADPOLES DURING THYROXINE-INDUCED METAMORPHOSIS.","14209954",193]
["Aflatoxin B1","Aflatoxin B1","D016604","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1981,"6800343","Morpho-pathologic lesions induced in frog tadpoles under the action of aflatoxin.","6800343",193]
["aflatoxin G1","aflatoxin G1","C027955","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1981,"6800343","Morpho-pathologic lesions induced in frog tadpoles under the action of aflatoxin.","6800343",193]
["Allopurinol","Allopurinol","D000493","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1982,"7066990","Electron microscopic study of leaf frog melanophore differentiation in culture, with special reference to allopurinol effect on pterorhodin formation.","7066990",193]
["Alloxan","Alloxan","D000496","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,1,1949,"24537050","[The effect of alloxan on the growth and development of the tadpoles of Rana temporaria L].","24537050",193]
["almorexant","almorexant","C519150","1_MIE",1156,1,"Dual oxidase","Inhibition","Dual Oxidases","D000074623","Dual Oxidases",2,2,2013,"22436395","The dual orexin receptor antagonist almorexant, alone and in combination with morphine, cocaine and amphetamine, on conditioned place preference and locomotor sensitization in the rat.","22436395",193]
["Amiloride","Amiloride","D000584","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1999,"10564201","Possible role of aldosterone and T(3) in development of amiloride-blockable SCC across frog skin in vivo.","10564201",193]
["Amiloride","Amiloride","D000584","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1985,"3877201","Differentiation of the active sodium transport system during metamorphosis in Rana catesbeiana skin in relation to cadmium- and amiloride-induced responses.","3877201",193]
["Amiloride","Amiloride","D000584","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1995,"7840151","Corticoid-induced differentiation of amiloride-blockable active Na+ transport across larval bullfrog skin in vitro.","7840151",193]
["Amiloride","Amiloride","D000584","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1993,"8408842","Different sensitivity to amiloride of body and tail skins of Rana catesbeiana tadpoles during metamorphosis.","8408842",193]
["Amiloride","Amiloride","D000584","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,1,2007,"17652085","(NDRG2) stimulates amiloride-sensitive Na+ currents in Xenopus laevis oocytes and fisher rat thyroid cells.","17652085",193]
["Aminopropionitrile","Aminopropionitrile","D000629","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,1976,"1085616","Influence of D-penicillamine and beta-aminopropionitril on the metamorphosis of Rana temporaria.","1085616",193]
["Aminopterin","Aminopterin","D000630","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1954,"13181077","Effect of aureomycin, B12, folic acid and aminopterin on the metamorphosis of tadpoles.","13181077",193]
["Ammonia","Ammonia","D000641","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,1972,"4539043","Effect of prolactin and growth hormone on the ammonia excretion of bullfrog tadpoles during normal and induced metamorphosis.","4539043",193]
["Ammonia","Ammonia","D000641","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1959,"14426063","Changes in the pattern of nitrogen excretion during the life cycle of the newt.","14426063",193]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C67,B67)","v":"Ammonia"},"Ammonia","D000641","6_AO",1101,6,"Amphibian metamorphosis","Altered",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J67,K67)","v":"Metamorphosis, Biological"},"D008675","Metamorphosis, Biological",2,4,1972,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q67,Q67)","v":"4539043"},"Effect of prolactin and growth hormone on the ammonia excretion of bullfrog tadpoles during normal and induced metamorphosis.","4539043",193]
["ammonium nitrate","ammonium nitrate","C006568","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,1999,"10475914","Effects of ammonium nitrate, sodium nitrate, and urea on red-legged frogs, Pacific treefrogs, and African clawed frogs.","10475914",193]
["ammonium perchlorate","ammonium perchlorate","C053506","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,2016,"27318278","Interactions between a small chronic increase in diel water temperature and exposure to a common environmental contaminant on development of Arizona tiger salamander larvae.","27318278",193]
["ammonium perchlorate","ammonium perchlorate","C053506","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2002,"11833812","Environmentally relevant concentrations of ammonium perchlorate inhibit development and metamorphosis in Xenopus laevis.","11833812",193]
["ammonium perchlorate","ammonium perchlorate","C053506","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2002,"11878472","Environmentally relevant concentrations of ammonium perchlorate inhibit thyroid function and alter sex ratios in developing Xenopus laevis.","11878472",193]
["ammonium perchlorate","ammonium perchlorate","C053506","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2016,"27318278","Interactions between a small chronic increase in diel water temperature and exposure to a common environmental contaminant on development of Arizona tiger salamander larvae.","27318278",193]
["ammonium perchlorate","ammonium perchlorate","C053506","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,2002,"11878472","Environmentally relevant concentrations of ammonium perchlorate inhibit thyroid function and alter sex ratios in developing Xenopus laevis.","11878472",193]
["ammonium perchlorate","ammonium perchlorate","C053506","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,2006,"16629145","Contribution of ammonium ions to the lethality and antimetamorphic effects of ammonium perchlorate.","16629145",193]
["amtizol","amtizol","C044365","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,1988,"3130597","[Effect of gutimine derivatives on the metamorphosis of Rana temporaria tadpoles].","3130597",193]
["arbekacin","arbekacin","C031986","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,1987,"3499743","Comparative vestibular toxicity of dibekacin, habekacin and cisplatin.","3499743",193]
["Ascorbic Acid","Ascorbic Acid","D001205","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,1967,"6058912","Ascorbic acid and testicular activity in heat-exposed toad (Bufo melanostictus).","6058912",193]
["Ascorbic Acid","Ascorbic Acid","D001205","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1964,"14202675","CHANGES IN THYROXINE DEIODINASE OF THE FROG, XENOPUS LAEVIS DAUDIN, DURING METAMORPHOSIS AND GROWTH.","14202675",193]
["Ascorbic Acid","Ascorbic Acid","D001205","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1965,"14329283","ON THE METABOLIC ROLE OF BETA -GLUCURONIDASE.","14329283",193]
["Ascorbic Acid","Ascorbic Acid","D001205","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1951,"14930650","[Quantitative variations of ascorbic acid during the metamorphosis of the Bufo vulgaris].","14930650",193]
["Ascorbic Acid","Ascorbic Acid","D001205","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,1965,"5863646","[Research on the metabolic conditioning of thyroxine action. II. Action of some indicators and modifiers of redox potential].","5863646",193]
["asphalt","asphalt","C006647","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,2010,"20696464","Toxicity of coal-tar and asphalt sealants to eastern newts, Notophthalmus viridescens.","20696464",193]
["Atrazine","Atrazine","D001280","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,2003,"12627652","Effects of sublethal concentrations of atrazine and nitrate on metamorphosis of the African clawed frog.","12627652",193]
["Atrazine","Atrazine","D001280","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,2002,"11871572","Atrazine linked to endocrine disruption in frogs.","11871572",193]
["Atrazine","Atrazine","D001280","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2002,"11960004","Hermaphroditic, demasculinized frogs after exposure to the herbicide atrazine at low ecologically relevant doses.","11960004",193]
["Atrazine","Atrazine","D001280","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,2002,"12411672","Amphibian declines. Conflict brewing over herbicide's link to frog deformities.","12411672",193]
["Atrazine","Atrazine","D001280","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2003,"12558173","Response of larval Xenopus laevis to atrazine: assessment of growth, metamorphosis, and gonadal and laryngeal morphology.","12558173",193]
["Atrazine","Atrazine","D001280","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2003,"12627652","Effects of sublethal concentrations of atrazine and nitrate on metamorphosis of the African clawed frog.","12627652",193]
["Atrazine","Atrazine","D001280","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2004,"15205037","Effects of atrazine on metamorphosis, growth, and gonadal development in the green frog (Rana clamitans).","15205037",193]
["Atrazine","Atrazine","D001280","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,2005,"16050581","Developmental impact of atrazine on metamorphing Xenopus laevis as revealed by nuclear analysis and morphology.","16050581",193]
["Atrazine","Atrazine","D001280","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,2005,"16082954","Gonadal development of larval male Xenopus laevis exposed to atrazine in outdoor microcosms.","16082954",193]
["Atrazine","Atrazine","D001280","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2005,"16112017","Effects of atrazine on metamorphosis, growth, laryngeal and gonadal development, aromatase activity, and sex steroid concentrations in Xenopus laevis.","16112017",193]
["Atrazine","Atrazine","D001280","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2005,"16213604","Differential metamorphosis alters the endocrine response in anuran larvae exposed to T3 and atrazine.","16213604",193]
["Atrazine","Atrazine","D001280","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2006,"16494238","Effects of atrazine and iridovirus infection on survival and life-history traits of the long-toed salamander (Ambystoma macrodactylum).","16494238",193]
["Atrazine","Atrazine","D001280","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2006,"16818259","Characterization of atrazine-induced gonadal malformations in African clawed frogs (Xenopus laevis) and comparisons with effects of an androgen antagonist (cyproterone acetate) and exogenous estrogen (17beta-estradiol): Support for the demasculinization/feminization hypothesis.","16818259",193]
["Atrazine","Atrazine","D001280","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,2006,"17205907","Atrazine increases ranavirus susceptibility in the tiger salamander, Ambystoma tigrinum.","17205907",193]
["Atrazine","Atrazine","D001280","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2008,"18338285","Effects of atrazine on anuran development are altered by the presence of a nonlethal predator.","18338285",193]
["Atrazine","Atrazine","D001280","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2008,"18395276","Effect of atrazine on metamorphosis and sexual differentiation in Xenopus laevis.","18395276",193]
["Atrazine","Atrazine","D001280","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2009,"18692913","Comparative susceptibility to atrazine of three developmental stages of Rhinella arenarum and influence on metamorphosis: non-monotonous acceleration of the time to climax and delayed tail resorption.","18692913",193]
["Atrazine","Atrazine","D001280","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2009,"19008211","Does atrazine influence larval development and sexual differentiation in Xenopus laevis?","19008211",193]
["Atrazine","Atrazine","D001280","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2009,"19272595","Chronic exposure to high levels of atrazine alters expression of genes that regulate immune and growth-related functions in developing Xenopus laevis tadpoles.","19272595",193]
["Atrazine","Atrazine","D001280","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2010,"20368127","Low levels of the herbicide atrazine alter sex ratios and reduce metamorphic success in Rana pipiens tadpoles raised in outdoor mesocosms.","20368127",193]
["Atrazine","Atrazine","D001280","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2010,"20809547","Acute atrazine exposure disrupts matrix metalloproteinases and retinoid signaling during organ morphogenesis in Xenopus laevis.","20809547",193]
["Atrazine","Atrazine","D001280","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2011,"21635867","Atrazine exposure affects growth, body condition and liver health in Xenopus laevis tadpoles.","21635867",193]
["Atrazine","Atrazine","D001280","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2012,"22419132","Sublethal effects of atrazine on embryo-larval development of Rhinella arenarum (Anura: Bufonidae).","22419132",193]
["Atrazine","Atrazine","D001280","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2013,"23499184","Environmentally-relevant concentrations of atrazine induce non-monotonic acceleration of developmental rate and increased size at metamorphosis in Rhinella arenarum tadpoles.","23499184",193]
["Atrazine","Atrazine","D001280","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2014,"25216249","Indicators of the statuses of amphibian populations and their potential for exposure to atrazine in four midwestern U.S. conservation areas.","25216249",193]
["Atrazine","Atrazine","D001280","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2015,"25533566","Assessing atrazine-induced toxicities in Bufo bufo gargarizans Cantor.","25533566",193]
["Atrazine","Atrazine","D001280","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2018,"29602044","Effects of environmentally relevant sub-chronic atrazine concentrations on African clawed frog (Xenopus laevis) survival, growth and male gonad development.","29602044",193]
["Atrazine","Atrazine","D001280","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,1998,"9798254","Effects of the herbicide atrazine on Ambystoma tigrinum metamorphosis: duration, larval growth, and hormonal response.","9798254",193]
["azocyclotin","azocyclotin","C000613986","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2017,"28213302","Disrupting effects of azocyclotin to the hypothalamo-pituitary-gonadal axis and reproduction of Xenopus laevis.","28213302",193]
["Baclofen","Baclofen","D001418","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2000,"11018769","Developmental disinhibition: turning off inhibition turns on breathing in vertebrates.","11018769",193]
["benthiocarb","benthiocarb","C037925","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2013,"23597675","Application of an amphibian (Silurana tropicalis) metamorphosis assay to the testing of the chronic toxicity of three rice paddy herbicides: simetryn, mefenacet, and thiobencarb.","23597675",193]
["bisphenol A","bisphenol A","C006780","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2003,"12919782","Assessing chronic toxicity of bisphenol A to larvae of the African clawed frog (Xenopus laevis) in a flow-through exposure system.","12919782",193]
["bisphenol A","bisphenol A","C006780","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2003,"12928009","Teratogenic and anti-metamorphic effects of bisphenol A on embryonic and larval Xenopus laevis.","12928009",193]
["bisphenol A","bisphenol A","C006780","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2004,"14643292","Bisphenol A induces feminization in Xenopus laevis tadpoles.","14643292",193]
["bisphenol A","bisphenol A","C006780","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2005,"16402308","Endocrine-disrupting effects of nonylphenol, bisphenol A, and p,p'-DDE on Rana nigromaculata tadpoles.","16402308",193]
["bisphenol A","bisphenol A","C006780","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2006,"16905155","Effects of bisphenol A on thyroid hormone-dependent up-regulation of thyroid hormone receptor alpha and beta and down-regulation of retinoid X receptor gamma in Xenopus tail culture.","16905155",193]
["bisphenol A","bisphenol A","C006780","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2007,"17268083","Bisphenol A causes malformation of the head region in embryos of Xenopus laevis and decreases the expression of the ESR-1 gene mediated by Notch signaling.","17268083",193]
["bisphenol A","bisphenol A","C006780","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2009,"19228888","The xenoestrogen bisphenol A inhibits postembryonic vertebrate development by antagonizing gene regulation by thyroid hormone.","19228888",193]
["bisphenol A","bisphenol A","C006780","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2010,"20178801","Amphibian metamorphosis as a model for studying endocrine disruption on vertebrate development: effect of bisphenol A on thyroid hormone action.","20178801",193]
["Blood Glucose","Blood Glucose","D001786","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,1964,"14181475","TOTAL PANCREATECTOMY IN TOADS: EFFECT OF HYPOPHYSECTOMY AND GLUCAGON.","14181475",193]
["Blood Glucose","Blood Glucose","D001786","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,1965,"14321279","EXPERIMENTAL LIVER POISONING OF THE FROG (RANA PIPIENS) WITH CARBON TETRACHLORIDE. I. LIVER-GLYCOGEN STORAGE, BLOOD-GLUCOSE LEVEL, AND CYTOCHROME-OXIDASE ACTIVITY.","14321279",193]
["Blood Glucose","Blood Glucose","D001786","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,1965,"14327183","HYPERTROPHY OF THE ISLETS OF LANGERHANS OF FROG TADPOLES AFTER PARTIAL PANCREATECTOMY.","14327183",193]
["Blood Glucose","Blood Glucose","D001786","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,1975,"236128","Cyclic changes in liver and muscle glycogen, tissue lipid and blood glucose in a naturally occurring population of Rana catesbeiana.","236128",193]
["Blood Glucose","Blood Glucose","D001786","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1964,"14131456","METAMORPHIC CHANGES IN THE BLOOD SUGAR AND THE PANCREATIC ISLETS OF THE FROG, RANA CLAMITANS.","14131456",193]
["Blood Glucose","Blood Glucose","D001786","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1965,"14327183","HYPERTROPHY OF THE ISLETS OF LANGERHANS OF FROG TADPOLES AFTER PARTIAL PANCREATECTOMY.","14327183",193]
["Blood Glucose","Blood Glucose","D001786","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1985,"2858315","The effect of dexamethasone on plasma glucose and liver glycogen levels in premetamorphic Rana catesbeiana tadpoles and frogs.","2858315",193]
["Blood Glucose","Blood Glucose","D001786","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1973,"4543477","Comparison of blood glucose and liver glycogen of larval and adult frogs (Rana pipiens).","4543477",193]
["Blood Glucose","Blood Glucose","D001786","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1977,"832822","The effects of biogenic amines on carbohydrate metabolism in Xenopus laevis Daudin.","832822",193]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C131,B131)","v":"Blood Glucose"},"Blood Glucose","D001786","2_KE",277,2,"Thyroid hormone synthesis","Decreased",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J131,K131)","v":"Thyroid Gland"},"D013961","Thyroid Gland",1,1,1994,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q131,Q131)","v":"7736347"},"Alterations in hepatic adrenergic receptor status in Rana sylvatica in response to freezing and thawing: implications to the freeze-induced glycemic response.","7736347",193]
["Bromocriptine","Bromocriptine","D001971","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,1983,"6132721","Effects of prolactin and bromocriptine in Discoglossus pictus (anuran amphibian. Otth) tadpoles.","6132721",193]
["butachlor","butachlor","C054409","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2016,"26971167","Exposure to butachlor causes thyroid endocrine disruption and promotion of metamorphosis in Xenopus laevis.","26971167",193]
["butachlor","butachlor","C054409","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,2016,"26971167","Exposure to butachlor causes thyroid endocrine disruption and promotion of metamorphosis in Xenopus laevis.","26971167",193]
["Calcium Carbonate","Calcium Carbonate","D002119","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1966,"5971997","The mobilization of the calcium carbonate deposits in the endolymphatic sacs of metamorphosing frogs.","5971997",193]
["Calcium, Dietary","Calcium, Dietary","D002136","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1964,"14272353","[INFLUENCE OF THE POTASSIUM--CALCIUM (K+--CA++) RATIO OF THE BREEDING MEDIUM ON THE SIZE OF THE INDIVIDUAL AND OVARIAN GROWTH IN THE TADPOLE, DISCOGLOSSUS PICTUS (OTTH)].","14272353",193]
["Calcium, Dietary","Calcium, Dietary","D002136","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,1,1970,"5482931","The ultimobranchial body in rana pipiens. XI. Response to increased dietary calcium--evidence of possible physiological function.","5482931",193]
["Camphor","Camphor","D002164","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2004,"15178063","Assessment of hormonal activity of UV filters in tadpoles of frog Xenopus laevis at environmental concentrations.","15178063",193]
["captax","captax","C005563","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2013,"23178179","Inhibition of the thyroid hormone pathway in Xenopus laevis by 2-mercaptobenzothiazole.","23178179",193]
["Carbamyl Phosphate","Carbamyl Phosphate","D002221","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1965,"14283188","FORMATION AND CONVERSION OF MACROMOLECULAR PRECURSOR(S) IN THE BIOSYNTHESIS OF CARBAMYL PHOSPHATE SYNTHETASE.","14283188",193]
["Carbaryl","Carbaryl","D012721","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,2003,"14587910","Effects of carbaryl on green frog (Rana clamitans) tadpoles: timing of exposure versus multiple exposures.","14587910",193]
["Carbaryl","Carbaryl","D012721","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2008,"18260698","Examining the single and interactive effects of three insecticides on amphibian metamorphosis.","18260698",193]
["Carbaryl","Carbaryl","D012721","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2011,"21221965","Carbaryl concentration gradients in realistic environments and their influence on our understanding of the tadpole food web.","21221965",193]
["Carbaryl","Carbaryl","D012721","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2011,"21298710","Pesticide has asymmetric effects on two tadpole species across density gradient.","21298710",193]
["Carbaryl","Carbaryl","D012721","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2011,"21462236","Juvenile green frog (Rana clamitans) predatory ability not affected by exposure to carbaryl at different times during larval development.","21462236",193]
["Carbaryl","Carbaryl","D012721","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2012,"22488856","Impact of an insecticide changes with amount of leaf litter input: implications for amphibian populations.","22488856",193]
["Carbaryl","Carbaryl","D012721","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2013,"23399446","Specific time of exposure during tadpole development influences biological effects of the insecticide carbaryl in green frogs (Lithobates clamitans).","23399446",193]
["Carbaryl","Carbaryl","D012721","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2014,"25044296","Effects of pesticide exposure and the amphibian chytrid fungus on gray treefrog (Hyla chrysoscelis) metamorphosis.","25044296",193]
["Carbaryl","Carbaryl","D012721","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2017,"27988452","Long term effects of carbaryl exposure on antiviral immune responses in Xenopus laevis.","27988452",193]
["Carbaryl","Carbaryl","D012721","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,1983,"6411006","Acute and chronic effect of carbaryl on survival, growth, and metamorphosis in the bullfrog (Rana tigrina).","6411006",193]
["Carbon Dioxide","Carbon Dioxide","D002245","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,1972,"4537783","An imidazole alphastat hypothesis for vertebrate acid-base regulation: tissue carbon dioxide content and body temperature in bullfrogs.","4537783",193]
["Carbon Dioxide","Carbon Dioxide","D002245","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,2003,"12571143","Central CO2 chemoreception in developing bullfrogs: anomalous response to acetazolamide.","12571143",193]
["Carbon Dioxide","Carbon Dioxide","D002245","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,2010,"20080209","Nicotine elicits a developmentally dependent depression in bullfrog neuroventilatory response to CO(2).","20080209",193]
["Carbon Dioxide","Carbon Dioxide","D002245","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1969,"5390263","[Behavior of the gas transport function of blood from the axolotl (Ambystoma mexicanum) as gill and lung breather].","5390263",193]
["Carbon Monoxide","Carbon Monoxide","D002248","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1964,"14216408","BIOCHEMICAL METAMORPHOSIS OF HEMOGLOBIN IN RANA CATESBEIANA. I. PURIFICATION PROCEDURES AND PROPERTIES OF HEMOGLOBINS FROM BULLFROG AND TADPOLE ERYTHROCYTES.","14216408",193]
["Carbon Tetrachloride","Carbon Tetrachloride","D002251","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,1965,"14321279","EXPERIMENTAL LIVER POISONING OF THE FROG (RANA PIPIENS) WITH CARBON TETRACHLORIDE. I. LIVER-GLYCOGEN STORAGE, BLOOD-GLUCOSE LEVEL, AND CYTOCHROME-OXIDASE ACTIVITY.","14321279",193]
["Carbon Tetrachloride","Carbon Tetrachloride","D002251","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,1972,"5036077","Effect of carbon tetrachloride in the body weight gain following an increased water intake and antidiuresis in toads: possible mode of action.","5036077",193]
["Carbon Tetrachloride","Carbon Tetrachloride","D002251","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,1968,"5721743","Increased water uptake and retention in amphibian by carbon tetrachloride.","5721743",193]
["Cellulose","Cellulose","D002482","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1964,"14191912","[SERUM PROTEIN CHANGES FOLLOWING METAMORPHOSIS IN THE URODELOUS AMPHIBIA PLEURODELES WALTLII MICHAH. AND SALAMANDRA SALAMANDRA L. STUDY BY ELECTROPHORESIS ON CELLULOSE ACETATE].","14191912",193]
["Chloramphenicol","Chloramphenicol","D002701","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,2000,"12197324","Induction of leukaemia in chloramphenicol-treated toads.","12197324",193]
["Chloramphenicol","Chloramphenicol","D002701","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,1966,"4165244","[Pharmacological studies on chloramphenicol-gamma globulin (Chlorabulin)].","4165244",193]
["Chloramphenicol","Chloramphenicol","D002701","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,1968,"4973701","[Action of thyroxine on Discoglossus pictus Otth larvae treated with actinomycin D and chloramphenicol].","4973701",193]
["Chlorobutanol","Chlorobutanol","D002724","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,1966,"5232394","The protective effects of some narcotic substances against x-irradiation in aquatic animals. (I). Effects of chlorobutanol in larvae of Rhacophorus arboreus.","5232394",193]
["Chlorobutanol","Chlorobutanol","D002724","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,1966,"5232396","The protective effects of some narcotic substances against x-irradiation on aquatic animals. (3). Effects of urethane and changes in concentration of chlorobuthanol solution against x-irradiation in larvae of Rhacophorus arboreus.","5232396",193]
["Chlorodiphenyl (54% Chlorine)","Chlorodiphenyl (54% Chlorine)","D020111","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,2009,"18407353","Effects of Aroclor 1254 on oxidative stress in developing Xenopus laevis tadpoles.","18407353",193]
["Chlorodiphenyl (54% Chlorine)","Chlorodiphenyl (54% Chlorine)","D020111","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,2009,"19011258","Protein expression profiling in the African clawed frog Xenopus laevis tadpoles exposed to the polychlorinated biphenyl mixture aroclor 1254.","19011258",193]
["Chlorodiphenyl (54% Chlorine)","Chlorodiphenyl (54% Chlorine)","D020111","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2005,"15721885","Dietary exposure to Aroclor 1254 alters gene expression in Xenopus laevis frogs.","15721885",193]
["Chlorodiphenyl (54% Chlorine)","Chlorodiphenyl (54% Chlorine)","D020111","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2006,"16720020","Polychlorinated biphenyl exposure delays metamorphosis and alters thyroid hormone system gene expression in developing Xenopus laevis.","16720020",193]
["Chlorodiphenyl (54% Chlorine)","Chlorodiphenyl (54% Chlorine)","D020111","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2007,"17675174","Feminizing/demasculinizing effects of polychlorinated biphenyls on the secondary sexual development of Xenopus laevis.","17675174",193]
["Chloroquine","Chloroquine","D002738","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1964,"14166715","EFFECTS OF CHLOROQUINE ON GROWTH AND METABOLISM.","14166715",193]
["Chlorpromazine","Chlorpromazine","D002746","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1961,"14454834","[Comparative action of reserpine, chlorpromazine and serotonin on the metamorphosis of the tadpole of Rana temporaria].","14454834",193]
["Chlorpropamide","Chlorpropamide","D002747","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,1971,"4257741","[Participation of the antidiuretic hormone (ADH) in the activity of chlorpropamide on water metabolism, in toads].","4257741",193]
["Chlorpyrifos","Chlorpyrifos","D004390","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,2006,"16986800","Cholinesterase activity and behavior in chlorpyrifos-exposed Rana sphenocephala tadpoles.","16986800",193]
["Chlorpyrifos","Chlorpyrifos","D004390","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2002,"12206422","Biochemical effects of chlorpyrifos on two developmental stages of Xenopus laevis.","12206422",193]
["Chlorpyrifos","Chlorpyrifos","D004390","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2003,"12587292","Physical effects of chlorpyrifos on two stages of xenopus laevis.","12587292",193]
["Chlorpyrifos","Chlorpyrifos","D004390","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2009,"19290680","Toxicity of two insecticides to California, USA, anurans and its relevance to declining amphibian populations.","19290680",193]
["Chlorpyrifos","Chlorpyrifos","D004390","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2011,"20669016","Chlorpyrifos-induced toxicity in Duttaphrynus melanostictus (Schneider 1799) larvae.","20669016",193]
["Chlorpyrifos","Chlorpyrifos","D004390","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2011,"21344266","Toxicity of chlorpyrifos to larval Rana dalmatina: acute and chronic effects on survival, development, growth and gill apparatus.","21344266",193]
["Chlorpyrifos","Chlorpyrifos","D004390","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2011,"21445987","Survival, development, and gonadal differentiation in Rana dalmatina chronically exposed to chlorpyrifos.","21445987",193]
["Chlorpyrifos","Chlorpyrifos","D004390","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2014,"25052219","Joint toxicity of chlorpyrifos and endosulfan to Pacific treefrog (Pseudacris regilla) tadpoles.","25052219",193]
["Chlortetracycline","Chlortetracycline","D002751","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1953,"13140507","[Effect of antibiotics on the metamorphosis of toad tadpoles. I. Effect of aureomycin].","13140507",193]
["Chlortetracycline","Chlortetracycline","D002751","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1954,"13181077","Effect of aureomycin, B12, folic acid and aminopterin on the metamorphosis of tadpoles.","13181077",193]
["Cholesterol","Cholesterol","D002784","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1964,"14184328","[ANALYSIS OF TRANSFORMATIONS OF SKIN PTERIDINES DURING THE LARVAL LIFE AND METAMORPHOSIS IN THE TRITON PLEURODELES WALTLII MICHAH. CHANGES INDUCED BY THE LOCALIZED ACTION OF THYROXIN-CHOLESTEROL IMPLANTS].","14184328",193]
["Cholesterol","Cholesterol","D002784","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1959,"14404190","Local action of thyroxin on amphibian metamorphosis. IV. Resorption of the tail fin in anuran larvae effected by thyroxin-cholesterol implants.","14404190",193]
["Cholesterol","Cholesterol","D002784","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,1972,"4536733","Local action of thyroxine on amphibian metamorphosis. V. Cell division in the eye of anuran larvae effected by thyroxine-cholesterol implants.","4536733",193]
["Choline","Choline","D002794","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1999,"10366031","Effects of choline and other nicotinic agonists on the tectum of juvenile and adult Xenopus frogs: a patch-clamp study.","10366031",193]
["Chondroitin","Chondroitin","D002807","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1970,"4245639","Degradation of glycosaminoglycans by tadpole tissue. Differences in activity toward chondroitin 4-sulfate and chondroitin 6-sulfate.","4245639",193]
["Cisplatin","Cisplatin","D002945","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,1987,"3499743","Comparative vestibular toxicity of dibekacin, habekacin and cisplatin.","3499743",193]
["citreoviridin","citreoviridin","C014416","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,1988,"3258434","Toxicity of citreoviridin.","3258434",193]
["Citric Acid","Citric Acid","D019343","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1962,"14453011","Effect of water-miscible preparation of vitamin D2 on metamorphosis of thiourea and citrate treated Rana pipiens larvae.","14453011",193]
["Clindamycin","Clindamycin","D002981","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,1974,"4546335","[Pharmacological studies on clindamycin-2-phosphate (author's transl)].","4546335",193]
["clophen A50","clophen A50","C025647","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,2000,"11059850","Effects of oral exposure to polychlorinated biphenyls (PCBs) on the development and metamorphosis of two amphibian species (Xenopus laevis and Rana temporaria).","11059850",193]
["clophen A50","clophen A50","C025647","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2000,"11059850","Effects of oral exposure to polychlorinated biphenyls (PCBs) on the development and metamorphosis of two amphibian species (Xenopus laevis and Rana temporaria).","11059850",193]
["Coal","Coal","D003031","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2004,"15036872","Species-specific responses of developing anurans to coal combustion wastes.","15036872",193]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C195,B195)","v":"Coal"},"Coal","D003031","6_AO",1101,6,"Amphibian metamorphosis","Altered",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J195,K195)","v":"Metamorphosis, Biological"},"D008675","Metamorphosis, Biological",2,4,2009,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q195,Q195)","v":"18627796"},"Exposure to coal combustion residues during metamorphosis elevates corticosterone content and adversely affects oral morphology, growth, and development in Rana sphenocephala.","18627796",193]
["Coal Ash","Coal Ash","D060729","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2014,"24169791","Differential patterns of accumulation and retention of dietary trace elements associated with coal ash during larval development and metamorphosis of an amphibian.","24169791",193]
["Coal Tar","Coal Tar","D003033","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,2010,"20696464","Toxicity of coal-tar and asphalt sealants to eastern newts, Notophthalmus viridescens.","20696464",193]
["Coal Tar","Coal Tar","D003033","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2006,"16557355","The effects of coal tar based pavement sealer on amphibian development and metamorphosis.","16557355",193]
["Colforsin","Colforsin","D005576","1_MIE",1156,1,"Dual oxidase","Inhibition","Dual Oxidases","D000074623","Dual Oxidases",2,2,2003,"12538618","Identification of a truncated dual oxidase 2 (DUOX2) messenger ribonucleic acid (mRNA) in two rat thyroid cell lines. Insulin and forskolin regulation of DUOX2 mRNA levels in FRTL-5 cells and porcine thyrocytes.","12538618",193]
["Cycloheximide","Cycloheximide","D003513","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,1992,"1505729","Thyroid hormone receptor induction by triiodothyronine in tadpole erythrocytes in vivo and in vitro and the effect of cycloheximide and actinomycin-D.","1505729",193]
["Cyclophosphamide","Cyclophosphamide","D003520","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,2000,"10713465","Diminished decondensation and DNA synthesis in activated sperm from rats treated with cyclophosphamide.","10713465",193]
["Cyclophosphamide","Cyclophosphamide","D003520","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1989,"2655227","Attempts to break perimetamorphically induced skin graft tolerance by treatment of Xenopus with cyclophosphamide and interleukin-2.","2655227",193]
["Cyclophosphamide","Cyclophosphamide","D003520","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,1970,"5518495","[Effect of sarcolysine and cyclophosphane on the resorption of tadpoles tail muscles in metamorphosis].","5518495",193]
["cypermethrin","cypermethrin","C017160","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2003,"13678851","Differences in susceptibility of various life stages of amphibians to pesticide exposure.","13678851",193]
["cypermethrin","cypermethrin","C017160","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2012,"22251205","Effects of combinations of malathion and cypermethrin on survivability and time of metamorphosis of tadpoles of Indian cricket frog (Fejervarya limnocharis).","22251205",193]
["Cyproterone Acetate","Cyproterone Acetate","D017373","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2006,"16818259","Characterization of atrazine-induced gonadal malformations in African clawed frogs (Xenopus laevis) and comparisons with effects of an androgen antagonist (cyproterone acetate) and exogenous estrogen (17beta-estradiol): Support for the demasculinization/feminization hypothesis.","16818259",193]
["Cytosine","Cytosine","D003596","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1964,"14209954","URACIL METABOLISM IN TADPOLES DURING THYROXINE-INDUCED METAMORPHOSIS.","14209954",193]
["DDT","DDT","D003634","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,1979,"313824","The influence of rearing density on the subsequent response to DDT dosing for tadpoles of the frog Rana temporaria.","313824",193]
["DDT","DDT","D003634","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,1972,"4542435","Effects of acute and chronic administration of DDT upon pituitary melanocyte-stimulating hormone (MSH) activity.","4542435",193]
["DDT","DDT","D003634","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1976,"11069","Postmetamorphic retention of C14DDT by wood frog tadpoles.","11069",193]
["decabromobiphenyl ether","decabromobiphenyl ether","C010902","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2010,"20608512","Thyroid disruption by technical decabromodiphenyl ether (DE-83R) at low concentrations in Xenopus laevis.","20608512",193]
["decabromobiphenyl ether","decabromobiphenyl ether","C010902","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,2010,"20608512","Thyroid disruption by technical decabromodiphenyl ether (DE-83R) at low concentrations in Xenopus laevis.","20608512",193]
["decamethrin","decamethrin","C017180","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,2009,"19267312","Toxicity and immune system effects of dietary deltamethrin exposure in tiger salamanders (Ambystoma tigrinum).","19267312",193]
["Demeclocycline","Demeclocycline","D003707","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,1985,"3923829","Demeclocycline-induced natriuresis and renal insufficiency: in vivo and in vitro studies.","3923829",193]
["Dexamethasone","Dexamethasone","D003907","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,2002,"12383443","Effects of dexamethasone treatment on iodothyronine deiodinase activities and on metamorphosis-related morphological changes in the axolotl (Ambystoma mexicanum).","12383443",193]
["Dexamethasone","Dexamethasone","D003907","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,2004,"15158126","Low submetamorphic doses of dexamethasone and thyroxine induce complete metamorphosis in the axolotl (Ambystoma mexicanum) when injected together.","15158126",193]
["Dexamethasone","Dexamethasone","D003907","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2002,"12383443","Effects of dexamethasone treatment on iodothyronine deiodinase activities and on metamorphosis-related morphological changes in the axolotl (Ambystoma mexicanum).","12383443",193]
["Dexamethasone","Dexamethasone","D003907","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2004,"15158126","Low submetamorphic doses of dexamethasone and thyroxine induce complete metamorphosis in the axolotl (Ambystoma mexicanum) when injected together.","15158126",193]
["Dexamethasone","Dexamethasone","D003907","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,2005,"15993107","Corticotropin-releasing hormone-mediated metamorphosis in the neotenic axolotl Ambystoma mexicanum: synergistic involvement of thyroxine and corticoids on brain type II deiodinase.","15993107",193]
["Dexamethasone","Dexamethasone","D003907","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1985,"2858315","The effect of dexamethasone on plasma glucose and liver glycogen levels in premetamorphic Rana catesbeiana tadpoles and frogs.","2858315",193]
["Dexamethasone","Dexamethasone","D003907","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,1984,"6610600","Binding of dexamethasone by hepatic, intestine, and tailfin cytosol in Rana catesbeiana tadpoles during spontaneous and triiodothyronine-induced metamorphosis.","6610600",193]
["Dexamethasone","Dexamethasone","D003907","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,1980,"7465810","The effects of dexamethasone (DXM) and vitamin A on the growth and metamorphosis of gamma irradiated thyroxine induced Bufo melanostictus tadpoles.","7465810",193]
["Dibekacin","Dibekacin","D003982","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,1987,"3499743","Comparative vestibular toxicity of dibekacin, habekacin and cisplatin.","3499743",193]
["Dibutyl Phthalate","Dibutyl Phthalate","D003993","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,2011,"21544203","Thyroid disruption by Di-n-butyl phthalate (DBP) and mono-n-butyl phthalate (MBP) in Xenopus laevis.","21544203",193]
["Dichlorodiphenyl Dichloroethylene","Dichlorodiphenyl Dichloroethylene","D003633","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2006,"17056472","Thyroid hormone-dependent gene expression as a biomarker of short-term 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) exposure in European common frog (Rana temporaria) tadpoles.","17056472",193]
["Diethylhexyl Phthalate","Diethylhexyl Phthalate","D004051","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2017,"29098770","Influence of DEHP on thyroid, sex steroid-related genes and gonadal differentiation in Rana chensinensis tadpoles.","29098770",193]
["Diethylhexyl Phthalate","Diethylhexyl Phthalate","D004051","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,2017,"29098770","Influence of DEHP on thyroid, sex steroid-related genes and gonadal differentiation in Rana chensinensis tadpoles.","29098770",193]
["Diltiazem","Diltiazem","D004110","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,1993,"7949401","Effect of calcium and calmodulin antagonists on metamorphosis in the anuran tadpole, Rana tigerina.","7949401",193]
["Dimethyl Sulfoxide","Dimethyl Sulfoxide","D004121","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,1970,"5312702","The effect of dimethyl sulphoxide on the radiation response of the rough-skinned newt (Taricha granulosa).","5312702",193]
["Dimethyl Sulfoxide","Dimethyl Sulfoxide","D004121","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,1971,"5542820","Acute toxicologic effects of dimethyl sulfoxide on the rough-skinned newt (Taricha granulosa).","5542820",193]
["Dimethyl Sulfoxide","Dimethyl Sulfoxide","D004121","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1986,"3489067","Forelimb regeneration in the postmetamorphic bullfrog: stimulation by dimethyl sulfoxide and retinoic acid.","3489067",193]
["Dimethyl Sulfoxide","Dimethyl Sulfoxide","D004121","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,1969,"5193735","Dimethyl sulfoxide: influence upon frog tadpole metamorphosis.","5193735",193]
["Dinoprostone","Dinoprostone","D015232","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1988,"3164274","Prostaglandin E2 does not inhibit metamorphosis of tadpole tails in tissue culture.","3164274",193]
["diphenyleneiodonium","diphenyleneiodonium","C007517","1_MIE",1156,1,"Dual oxidase","Inhibition","Dual Oxidases","D000074623","Dual Oxidases",2,4,2017,"28709950","Characterization of potent and selective iodonium-class inhibitors of NADPH oxidases.","28709950",193]
["Dopamine","Dopamine","D004298","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,2001,"11226628","Day/night variations of dopamine ocular content during Xenopus laevis ontogeny.","11226628",193]
["Dopamine","Dopamine","D004298","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,2005,"16075267","Ontogeny of central melatonin receptors in tadpoles of the anuran Rana perezi: modulation of dopamine release.","16075267",193]
["Dopamine","Dopamine","D004298","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1980,"6968286","Possible involvement of dopamine in the release of prolactin-like hormone from bullfrog pituitary gland.","6968286",193]
["Dopamine","Dopamine","D004298","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,1998,"9510433","Melatonin accelerates metamorphosis in Xenopus laevis.","9510433",193]
["Endosulfan","Endosulfan","D004726","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,2009,"18950876","Environmentally relevant concentrations of endosulfan impair development, metamorphosis and behaviour in Bufo bufo tadpoles.","18950876",193]
["Endosulfan","Endosulfan","D004726","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2009,"18950876","Environmentally relevant concentrations of endosulfan impair development, metamorphosis and behaviour in Bufo bufo tadpoles.","18950876",193]
["Endosulfan","Endosulfan","D004726","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2009,"19290680","Toxicity of two insecticides to California, USA, anurans and its relevance to declining amphibian populations.","19290680",193]
["Endosulfan","Endosulfan","D004726","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2010,"20886432","Gill alterations as biomarkers of chronic exposure to endosulfan in Bufo bufo tadpoles.","20886432",193]
["Endosulfan","Endosulfan","D004726","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2013,"23064781","Endosulfan effects on Rana dalmatina tadpoles: quantitative developmental and behavioural analysis.","23064781",193]
["Endosulfan","Endosulfan","D004726","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2013,"24068650","Toxicity of endosulfan to tadpoles of Fejervarya spp. (Anura: Dicroglossidae): mortality and morphological deformities.","24068650",193]
["Endosulfan","Endosulfan","D004726","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2014,"24375551","Toxicity of endosulfan on embryo-larval development of the South American toad Rhinella arenarum.","24375551",193]
["Endosulfan","Endosulfan","D004726","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2014,"25052219","Joint toxicity of chlorpyrifos and endosulfan to Pacific treefrog (Pseudacris regilla) tadpoles.","25052219",193]
["entinostat","entinostat","C118739","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,2006,"16583304","Factors affecting the pharmacokinetic profile of MS-275, a novel histone deacetylase inhibitor, in patients with cancer.","16583304",193]
["enzacamene","enzacamene","C038939","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2004,"15178063","Assessment of hormonal activity of UV filters in tadpoles of frog Xenopus laevis at environmental concentrations.","15178063",193]
["Epinephrine","Epinephrine","D004837","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,1957,"13444787","[Spermiation in Rana esculenta ridibundi peruzi; influence of weight, temperature, state of thyroid, adrenalin and testosterone].","13444787",193]
["Epinephrine","Epinephrine","D004837","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,1970,"5473788","Studies on myocardial catecholamines related to species ages and sex.","5473788",193]
["Epinephrine","Epinephrine","D004837","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1958,"13576433","[Effect of pitressin &amp; adrenalin on water balance in the toad during &amp; after metamorphosis].","13576433",193]
["Epinephrine","Epinephrine","D004837","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1977,"411709","Catecholamine-secreting cells in the adrenal gland of Bufo bufo during metamorphosis and in the adult.","411709",193]
["Epinephrine","Epinephrine","D004837","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,1,1957,"13444787","[Spermiation in Rana esculenta ridibundi peruzi; influence of weight, temperature, state of thyroid, adrenalin and testosterone].","13444787",193]
["Epinephrine","Epinephrine","D004837","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,1997,"9502523","The effect of posterior lobe extract, adrenalin, and pilocarpine on the response of the thyroid gland to the thyreoactivator hormone of the anterior lobe of the hypophysis.","9502523",193]
["ergocornine","ergocornine","C100271","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,1979,"583463","Effects of ergocornine and reserpine on metamorphosis in Bufo bufo japonicus tadpoles.","583463",193]
["ergotoxine","ergotoxine","C100272","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,1979,"583463","Effects of ergocornine and reserpine on metamorphosis in Bufo bufo japonicus tadpoles.","583463",193]
["Ethanol","Ethanol","D000431","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2013,"23174618","Chronic, but not acute, ethanol exposure impairs central hypercapnic ventilatory drive in bullfrog tadpoles.","23174618",193]
["Ethanol","Ethanol","D000431","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,1983,"6648833","Craniofacial malformation in Xenopus laevis tadpoles caused by the exposure of early embryos to ethanol.","6648833",193]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C259,B259)","v":"Ethanol"},"Ethanol","D000431","2_KE",277,2,"Thyroid hormone synthesis","Decreased",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J259,K259)","v":"Thyroid Gland"},"D013961","Thyroid Gland",1,1,1952,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q259,Q259)","v":"13048493"},"[Experimental studies on alcohol oxyphore; determination of catalase activity in Bufo viridis larvae exposed to thyroid extracts].","13048493",193]
["Ethylenethiourea","Ethylenethiourea","D005031","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2005,"15779766","Description and initial evaluation of a Xenopus metamorphosis assay for detection of thyroid system-disrupting activities of environmental compounds.","15779766",193]
["Ethylenethiourea","Ethylenethiourea","D005031","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2006,"16396842","Evaluation of histological and molecular endpoints for enhanced detection of thyroid system disruption in Xenopus laevis tadpoles.","16396842",193]
["Ethylenethiourea","Ethylenethiourea","D005031","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,1,2005,"15779766","Description and initial evaluation of a Xenopus metamorphosis assay for detection of thyroid system-disrupting activities of environmental compounds.","15779766",193]
["Ethylenethiourea","Ethylenethiourea","D005031","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,2006,"16396842","Evaluation of histological and molecular endpoints for enhanced detection of thyroid system disruption in Xenopus laevis tadpoles.","16396842",193]
["Ethylenethiourea","Ethylenethiourea","D005031","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,2009,"18801409","Perchlorate and ethylenethiourea induce different histological and molecular alterations in a non-mammalian vertebrate model of thyroid goitrogenesis.","18801409",193]
["Eugenol","Eugenol","D005054","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,2010,"20819393","Eugenol anesthesia in African clawed frogs (Xenopus laevis) of different body weights.","20819393",193]
["Fadrozole","Fadrozole","D017316","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,2009,"18804292","Sex reversal of the amphibian, Xenopus tropicalis, following larval exposure to an aromatase inhibitor.","18804292",193]
["Fadrozole","Fadrozole","D017316","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2009,"20130388","The aromatase inhibitor fadrozole and the 5-reductase inhibitor finasteride affect gonadal differentiation and gene expression in the frog Silurana tropicalis.","20130388",193]
["fenoxycarb","fenoxycarb","C052034","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,2017,"28634053","Using short-term bioassays to evaluate the endocrine disrupting capacity of the pesticides linuron and fenoxycarb.","28634053",193]
["fenpropimorph","fenpropimorph","C050435","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,2005,"16173566","Common pesticide increases costs of antipredator defenses in Rana temporaria tadpoles.","16173566",193]
["Finasteride","Finasteride","D018120","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2009,"20130388","The aromatase inhibitor fadrozole and the 5-reductase inhibitor finasteride affect gonadal differentiation and gene expression in the frog Silurana tropicalis.","20130388",193]
["fludioxonil","fludioxonil","C108339","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2016,"27214195","Effects of a fungicide formulation on embryo-larval development, metamorphosis, and gonadogenesis of the South American toad Rhinella arenarum.","27214195",193]
["Fluorouracil","Fluorouracil","D005472","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,2016,"27729739","Rhubarb extract partially improves mucosal integrity in chemotherapy-induced intestinal mucositis.","27729739",193]
["Fluorouracil","Fluorouracil","D005472","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1970,"5442892","[Abnormalities of the Triturus embryo caused by 5-fluorouracil].","5442892",193]
["Fluoxetine","Fluoxetine","D005473","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2009,"19572769","Growth and development of tadpoles (Xenopus laevis) exposed to selective serotonin reuptake inhibitors, fluoxetine and sertraline, throughout metamorphosis.","19572769",193]
["Fluoxetine","Fluoxetine","D005473","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2013,"23383055","Developmental exposure to fluoxetine modulates the serotonin system in hypothalamus.","23383055",193]
["Fluoxetine","Fluoxetine","D005473","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,2013,"23383055","Developmental exposure to fluoxetine modulates the serotonin system in hypothalamus.","23383055",193]
["Folic Acid","Folic Acid","D005492","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1954,"13181077","Effect of aureomycin, B12, folic acid and aminopterin on the metamorphosis of tadpoles.","13181077",193]
["Galactose","Galactose","D005690","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1970,"5484669","Frog brain uridine diphosphate galactose-N-acetylgalactosaminyl-N-acetylneuraminylgalactosylglucosylceramide galactosyltransferase.","5484669",193]
["galaxolide","galaxolide","C033119","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,2016,"26472276","Effects of dietary exposure of polycyclic musk HHCB on the metamorphosis of Xenopus laevis.","26472276",193]
["galaxolide","galaxolide","C033119","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2016,"26472276","Effects of dietary exposure of polycyclic musk HHCB on the metamorphosis of Xenopus laevis.","26472276",193]
["galaxolide","galaxolide","C033119","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,2016,"26472276","Effects of dietary exposure of polycyclic musk HHCB on the metamorphosis of Xenopus laevis.","26472276",193]
["GC 1 compound","GC 1 compound","C413355","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,2004,"15056670","Induction of larval tissue resorption in Xenopus laevis tadpoles by the thyroid hormone receptor agonist GC-1.","15056670",193]
["Glucose","Glucose","D005947","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,1996,"8766908","Freezing tolerance/intolerance and cryoprotectant synthesis in terrestrially overwintering anurans in the Great Plains, USA.","8766908",193]
["Glucose","Glucose","D005947","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1964,"14131456","METAMORPHIC CHANGES IN THE BLOOD SUGAR AND THE PANCREATIC ISLETS OF THE FROG, RANA CLAMITANS.","14131456",193]
["Glucose","Glucose","D005947","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1964,"14209953","PATHWAY OF PYRIMIDINE BIOSYNTHESIS IN PREMETAMORPHIC TADPOLES.","14209953",193]
["Glucose","Glucose","D005947","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1990,"2334002","Ontogenetic development of transporter regulation in bullfrog intestine.","2334002",193]
["Glutethimide","Glutethimide","D005984","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1964,"14248715","THALIDOMIDE AND INDUCED AMPHIBIAN METAMORPHOSIS.","14248715",193]
["Glycogen","Glycogen","D006003","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,1964,"14181475","TOTAL PANCREATECTOMY IN TOADS: EFFECT OF HYPOPHYSECTOMY AND GLUCAGON.","14181475",193]
["Glycogen","Glycogen","D006003","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,1975,"236128","Cyclic changes in liver and muscle glycogen, tissue lipid and blood glucose in a naturally occurring population of Rana catesbeiana.","236128",193]
["Glycogen","Glycogen","D006003","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1986,"3781399","Variability of lipids and glycogen during hind limb regeneration in larval and metamorphose stages of Bufo regularis Reuss.","3781399",193]
["Glycogen","Glycogen","D006003","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1977,"832822","The effects of biogenic amines on carbohydrate metabolism in Xenopus laevis Daudin.","832822",193]
["Guanine","Guanine","D006147","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1972,"4540813","Guanine formation in isolated iridophores from bullfrog tadpoles.","4540813",193]
["Guanylthiourea","Guanylthiourea","D006164","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,1988,"3130597","[Effect of gutimine derivatives on the metamorphosis of Rana temporaria tadpoles].","3130597",193]
["Heme","Heme","D006418","1_MIE",1156,1,"Dual oxidase","Inhibition","Dual Oxidases","D000074623","Dual Oxidases",2,2,2009,"19460756","Caenorhabditis elegans and human dual oxidase 1 (DUOX1) \"peroxidase\" domains: insights into heme binding and catalytic activity.","19460756",193]
["Heme","Heme","D006418","1_MIE",1156,1,"Dual oxidase","Inhibition","Dual Oxidases","D000074623","Dual Oxidases",2,2,2010,"20947510","Perturbed heme binding is responsible for the blistering phenotype associated with mutations in the Caenorhabditis elegans dual oxidase 1 (DUOX1) peroxidase domain.","20947510",193]
["Heparin","Heparin","D006493","1_MIE",1156,1,"Dual oxidase","Inhibition","Dual Oxidases","D000074623","Dual Oxidases",2,2,2012,"21984036","Regulation of PMA-induced MUC5AC expression by heparin in human bronchial epithelial cells.","21984036",193]
["Histamine","Histamine","D006632","1_MIE",1156,1,"Dual oxidase","Inhibition","Dual Oxidases","D000074623","Dual Oxidases",2,2,2014,"23962049","Histamine stimulates hydrogen peroxide production by bronchial epithelial cells via histamine H1 receptor and dual oxidase.","23962049",193]
["Histamine","Histamine","D006632","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1951,"14796761","Antihistamines and thyroxine metamorphosis in tadpoles.","14796761",193]
["Histamine","Histamine","D006632","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1997,"9031731","Development of bombesin-like and histamine-like innervation in the bullfrog (Rana catesbeiana) central nervous system.","9031731",193]
["Hyaluronic Acid","Hyaluronic Acid","D006820","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1965,"14285484","HYALURONIDASE FROM TADPOLE TISSUE.","14285484",193]
["Hydroflumethiazide","Hydroflumethiazide","D006857","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,1964,"14144600","[STUDY ON ALDOSTERONE AND ELECTROLYTE METABOLISM IN CARDIAC INSUFFICIENCY].","14144600",193]
["Hydrogen Peroxide","Hydrogen Peroxide","D006861","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,1988,"3249021","Physiological significance of catalase and glutathione peroxidases, and in vivo peroxidation, in selected tissues of the toad Discoglossus pictus (Amphibia) during acclimation to normobaric hyperoxia.","3249021",193]
["Hydrogen Peroxide","Hydrogen Peroxide","D006861","1_MIE",1156,1,"Dual oxidase","Inhibition","Dual Oxidases","D000074623","Dual Oxidases",2,2,2002,"11822874","Characterization of ThOX proteins as components of the thyroid H(2)O(2)-generating system.","11822874",193]
["Hydrogen Peroxide","Hydrogen Peroxide","D006861","1_MIE",1156,1,"Dual oxidase","Inhibition","Dual Oxidases","D000074623","Dual Oxidases",2,2,2003,"12824283","Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense.","12824283",193]
["Hydrogen Peroxide","Hydrogen Peroxide","D006861","1_MIE",1156,1,"Dual oxidase","Inhibition","Dual Oxidases","D000074623","Dual Oxidases",2,4,2005,"15677770","Regulated hydrogen peroxide production by Duox in human airway epithelial cells.","15677770",193]
["Hydrogen Peroxide","Hydrogen Peroxide","D006861","1_MIE",1156,1,"Dual oxidase","Inhibition","Dual Oxidases","D000074623","Dual Oxidases",2,2,2005,"15972824","Dual oxidase-2 has an intrinsic Ca2+-dependent H2O2-generating activity.","15972824",193]
["Hydrogen Peroxide","Hydrogen Peroxide","D006861","1_MIE",1156,1,"Dual oxidase","Inhibition","Dual Oxidases","D000074623","Dual Oxidases",2,2,2007,"17332529","Duox expression and related H2O2 measurement in mouse thyroid: onset in embryonic development and regulation by TSH in adult.","17332529",193]
["Hydrogen Peroxide","Hydrogen Peroxide","D006861","1_MIE",1156,1,"Dual oxidase","Inhibition","Dual Oxidases","D000074623","Dual Oxidases",2,2,2007,"17643428","Duox1 is the main source of hydrogen peroxide in the rat thyroid cell line PCCl3.","17643428",193]
["Hydrogen Peroxide","Hydrogen Peroxide","D006861","1_MIE",1156,1,"Dual oxidase","Inhibition","Dual Oxidases","D000074623","Dual Oxidases",2,2,2008,"18230830","Negative correlation between thyroperoxidase and dual oxidase H2O2-generating activities in thyroid nodular lesions.","18230830",193]
["Hydrogen Peroxide","Hydrogen Peroxide","D006861","1_MIE",1156,1,"Dual oxidase","Inhibition","Dual Oxidases","D000074623","Dual Oxidases",2,2,2009,"19913458","Dual oxidases and hydrogen peroxide in a complex dialogue between host mucosae and bacteria.","19913458",193]
["Hydrogen Peroxide","Hydrogen Peroxide","D006861","1_MIE",1156,1,"Dual oxidase","Inhibition","Dual Oxidases","D000074623","Dual Oxidases",2,2,2010,"20085766","Characterization of hydrogen peroxide production by Duox in bronchial epithelial cells exposed to Pseudomonas aeruginosa.","20085766",193]
["Hydrogen Peroxide","Hydrogen Peroxide","D006861","1_MIE",1156,1,"Dual oxidase","Inhibition","Dual Oxidases","D000074623","Dual Oxidases",2,2,2010,"20122987","Defects of thyroidal hydrogen peroxide generation in congenital hypothyroidism.","20122987",193]
["Hydrogen Peroxide","Hydrogen Peroxide","D006861","1_MIE",1156,1,"Dual oxidase","Inhibition","Dual Oxidases","D000074623","Dual Oxidases",2,2,2010,"20187165","Compound heterozygosity for a novel hemizygous missense mutation and a partial deletion affecting the catalytic core of the H2O2-generating enzyme DUOX2 associated with transient congenital hypothyroidism.","20187165",193]
["Hydrogen Peroxide","Hydrogen Peroxide","D006861","1_MIE",1156,1,"Dual oxidase","Inhibition","Dual Oxidases","D000074623","Dual Oxidases",2,2,2010,"20407074","Dual oxidase, hydrogen peroxide and thyroid diseases.","20407074",193]
["Hydrogen Peroxide","Hydrogen Peroxide","D006861","1_MIE",1156,1,"Dual oxidase","Inhibition","Dual Oxidases","D000074623","Dual Oxidases",2,2,2010,"21146788","Urothelial cells produce hydrogen peroxide through the activation of Duox1.","21146788",193]
["Hydrogen Peroxide","Hydrogen Peroxide","D006861","1_MIE",1156,1,"Dual oxidase","Inhibition","Dual Oxidases","D000074623","Dual Oxidases",2,2,2011,"21389273","Lipid raft-dependent activation of dual oxidase 1/H2O2/NF-κB pathway in bronchial epithelial cells.","21389273",193]
["Hydrogen Peroxide","Hydrogen Peroxide","D006861","1_MIE",1156,1,"Dual oxidase","Inhibition","Dual Oxidases","D000074623","Dual Oxidases",2,2,2010,"21510483","H2O2, signal, substrate, mutagen and chemorepellent from physiology to biochemistry and disease.","21510483",193]
["Hydrogen Peroxide","Hydrogen Peroxide","D006861","1_MIE",1156,1,"Dual oxidase","Inhibition","Dual Oxidases","D000074623","Dual Oxidases",2,2,2012,"22874065","Regulation of dual oxidase expression and H2O2 production by thyroglobulin.","22874065",193]
["Hydrogen Peroxide","Hydrogen Peroxide","D006861","1_MIE",1156,1,"Dual oxidase","Inhibition","Dual Oxidases","D000074623","Dual Oxidases",2,2,2013,"23010498","Thyroid hydrogen peroxide production is enhanced by the Th2 cytokines, IL-4 and IL-13, through increased expression of the dual oxidase 2 and its maturation factor DUOXA2.","23010498",193]
["Hydrogen Peroxide","Hydrogen Peroxide","D006861","1_MIE",1156,1,"Dual oxidase","Inhibition","Dual Oxidases","D000074623","Dual Oxidases",2,2,2013,"23121369","Spatial and temporal analysis of NADPH oxidase-generated hydrogen peroxide signals by novel fluorescent reporter proteins.","23121369",193]
["Hydrogen Peroxide","Hydrogen Peroxide","D006861","1_MIE",1156,1,"Dual oxidase","Inhibition","Dual Oxidases","D000074623","Dual Oxidases",2,2,2013,"23404134","Genetic defects of hydrogen peroxide generation in the thyroid gland.","23404134",193]
["Hydrogen Peroxide","Hydrogen Peroxide","D006861","1_MIE",1156,1,"Dual oxidase","Inhibition","Dual Oxidases","D000074623","Dual Oxidases",2,2,2014,"23962049","Histamine stimulates hydrogen peroxide production by bronchial epithelial cells via histamine H1 receptor and dual oxidase.","23962049",193]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C323,B323)","v":"Hydrogen Peroxide"},"Hydrogen Peroxide","D006861","1_MIE",1156,1,"Dual oxidase","Inhibition",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J323,K323)","v":"Dual Oxidases"},"D000074623","Dual Oxidases",2,2,2014,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q323,Q323)","v":"24332816"},"Hydrogen peroxide generated by DUOX1 regulates the expression levels of specific differentiation markers in normal human keratinocytes.","24332816",193]
["Hydrogen Peroxide","Hydrogen Peroxide","D006861","1_MIE",1156,1,"Dual oxidase","Inhibition","Dual Oxidases","D000074623","Dual Oxidases",2,2,2014,"24492313","DUOX2 and DUOXA2 form the predominant enzyme system capable of producing the reactive oxygen species H2O2 in active ulcerative colitis and are modulated by 5-aminosalicylic acid.","24492313",193]
["Hydrogen Peroxide","Hydrogen Peroxide","D006861","1_MIE",1156,1,"Dual oxidase","Inhibition","Dual Oxidases","D000074623","Dual Oxidases",2,2,2015,"25586178","The extracellular A-loop of dual oxidases affects the specificity of reactive oxygen species release.","25586178",193]
["Hydrogen Peroxide","Hydrogen Peroxide","D006861","1_MIE",1156,1,"Dual oxidase","Inhibition","Dual Oxidases","D000074623","Dual Oxidases",2,4,2016,"27110716","Nox4 and Duox1/2 Mediate Redox Activation of Mesenchymal Cell Migration by PDGF.","27110716",193]
["Hydrogen Peroxide","Hydrogen Peroxide","D006861","1_MIE",1156,1,"Dual oxidase","Inhibition","Dual Oxidases","D000074623","Dual Oxidases",2,2,2016,"27262981","Epidermal growth factor-induced hydrogen peroxide production is mediated by dual oxidase 1.","27262981",193]
["Hydrogen Peroxide","Hydrogen Peroxide","D006861","1_MIE",1156,1,"Dual oxidase","Inhibition","Dual Oxidases","D000074623","Dual Oxidases",2,2,2017,"28648510","Disorders of H2O2 generation.","28648510",193]
["Hydrogen Peroxide","Hydrogen Peroxide","D006861","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1988,"3391802","Cytochemical studies of hydrogen peroxide production in the tadpole tail of Rana japonica during metamorphic climax.","3391802",193]
["Hydroxypropiophenone","Hydroxypropiophenone","D006910","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1952,"13008501","[Effect of hydroxypropiophenone on the somatic development and metamorphosis of larvae of Bufo viridis and Rana agilis].","13008501",193]
["Hydroxypropiophenone","Hydroxypropiophenone","D006910","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1952,"13031198","[Effect of p-hydroxypropiophenone on natural and experimental metamorphosis in Alytes obstetricans Laur. larvae].","13031198",193]
["Hydroxypropiophenone","Hydroxypropiophenone","D006910","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,1,1960,"13718362","Inhibitory effect of para-hydroxypropiophenone on the development of gonad in thyroidectomized frog larvae.","13718362",193]
["Hypochlorous Acid","Hypochlorous Acid","D006997","1_MIE",1156,1,"Dual oxidase","Inhibition","Dual Oxidases","D000074623","Dual Oxidases",2,4,2015,"26504017","Intercellular HOCl-mediated Apoptosis Induction in Malignant Cells: Interplay Between NOX1-Dependent Superoxide Anion Generation and DUOX-related HOCl-generating Peroxidase Activity.","26504017",193]
["Ice","Ice","D007053","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,2006,"16159689","Effects of road de-icing salt (NaCl) on larval wood frogs (Rana sylvatica).","16159689",193]
["imidacloprid","imidacloprid","C082359","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2017,"28248437","Sublethal effects on wood frogs chronically exposed to environmentally relevant concentrations of two neonicotinoid insecticides.","28248437",193]
["imidazole","imidazole","C029899","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1954,"13229018","[Effect of 1-methyl-2-mercapto imidazol on natural and experimental metamorphosis of larvae of Alytes obstetricans Laurenti].","13229018",193]
["indium tin oxide","indium tin oxide","C109984","1_MIE",1156,1,"Dual oxidase","Inhibition","Dual Oxidases","D000074623","Dual Oxidases",2,2,2012,"22944870","Directed differentiation of embryonic P19 cells and neural stem cells into neural lineage on conducting PEDOT-PEG and ITO glass substrates.","22944870",193]
["Industrial Waste","Industrial Waste","D007220","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2004,"15036872","Species-specific responses of developing anurans to coal combustion wastes.","15036872",193]
["Industrial Waste","Industrial Waste","D007220","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2006,"16842868","Effects of competition and coal-combustion wastes on recruitment and life history characteristics of salamanders in temporary wetlands.","16842868",193]
["Industrial Waste","Industrial Waste","D007220","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2011,"21036440","Compromised metamorphosis and thyroid hormone changes in wood frogs (Lithobates sylvaticus) raised on reclaimed wetlands on the Athabasca oil sands.","21036440",193]
["Inositol","Inositol","D007294","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1971,"5568185","The effect of organic phosphates on the allosteric property of Rana catesbeiana hemoglobins.","5568185",193]
["Inositol","Inositol","D007294","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1981,"7295756","Light stimulates the incorporation of inositol into phosphatidylinositol in the retina.","7295756",193]
["iodonium thiophene","iodonium thiophene","C051503","1_MIE",1156,1,"Dual oxidase","Inhibition",null,"D000074623","Dual Oxidases",2,4,2017,"28709950","Characterization of potent and selective iodonium-class inhibitors of NADPH oxidases.","28709950",193]
["Iproniazid","Iproniazid","D007490","6_AO",1101,6,"Amphibian metamorphosis","Altered",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J344,K344)","v":"Metamorphosis, Biological"},"D008675","Metamorphosis, Biological",2,4,1971,"5571386","The effects of iproniazid upon brain size and larval behavior of developing Xenopus laevis.","5571386",193]
["Kanamycin","Kanamycin","D007612","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,1987,"3499743","Comparative vestibular toxicity of dibekacin, habekacin and cisplatin.","3499743",193]
["Kanamycin","Kanamycin","D007612","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,1974,"4546642","[Pharmacological studies on BB-K8 (author's transl)].","4546642",193]
["Latex","Latex","D007840","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1994,"7833509","Lethal effect of latex gloves on Xenopus laevis tadpoles.","7833509",193]
["Levonorgestrel","Levonorgestrel","D016912","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2016,"27262936","The synthetic gestagen levonorgestrel directly affects gene expression in thyroid and pituitary glands of Xenopus laevis tadpoles.","27262936",193]
["Levonorgestrel","Levonorgestrel","D016912","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,2011,"21705715","The synthetic gestagen levonorgestrel impairs metamorphosis in Xenopus laevis by disruption of the thyroid system.","21705715",193]
["Levonorgestrel","Levonorgestrel","D016912","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,2016,"27262936","The synthetic gestagen levonorgestrel directly affects gene expression in thyroid and pituitary glands of Xenopus laevis tadpoles.","27262936",193]
["Lewis X Antigen","Lewis X Antigen","D016256","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,2001,"11778741","Differential expression of two carbohydrate epitopes, CD15 and HNK-1, in developing vertebrate olfactory receptor neurones.","11778741",193]
["Lindane","Lindane","D001556","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,1982,"6188517","[Effects of lindane, an organochlorine insecticide, on the thyroid gland of larvae of Xenopus laevis Daudin in premetamorphosis].","6188517",193]
["Linuron","Linuron","D008044","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,2017,"28634053","Using short-term bioassays to evaluate the endocrine disrupting capacity of the pesticides linuron and fenoxycarb.","28634053",193]
["Liver Glycogen","Liver Glycogen","D008112","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,1964,"14181475","TOTAL PANCREATECTOMY IN TOADS: EFFECT OF HYPOPHYSECTOMY AND GLUCAGON.","14181475",193]
["Liver Glycogen","Liver Glycogen","D008112","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,1965,"14321279","EXPERIMENTAL LIVER POISONING OF THE FROG (RANA PIPIENS) WITH CARBON TETRACHLORIDE. I. LIVER-GLYCOGEN STORAGE, BLOOD-GLUCOSE LEVEL, AND CYTOCHROME-OXIDASE ACTIVITY.","14321279",193]
["Liver Glycogen","Liver Glycogen","D008112","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,1975,"236128","Cyclic changes in liver and muscle glycogen, tissue lipid and blood glucose in a naturally occurring population of Rana catesbeiana.","236128",193]
["Liver Glycogen","Liver Glycogen","D008112","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,1998,"9472816","Glyconeogenesis and urea synthesis in the toad Bufo viridis during acclimation to water restriction.","9472816",193]
["Liver Glycogen","Liver Glycogen","D008112","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1985,"2858315","The effect of dexamethasone on plasma glucose and liver glycogen levels in premetamorphic Rana catesbeiana tadpoles and frogs.","2858315",193]
["Liver Glycogen","Liver Glycogen","D008112","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1973,"4543477","Comparison of blood glucose and liver glycogen of larval and adult frogs (Rana pipiens).","4543477",193]
["Liver Glycogen","Liver Glycogen","D008112","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1979,"539369","Levels of liver glycogen during normal and radiation-induced metamorphosis in Rana cyanophlyctis.","539369",193]
["Liver Glycogen","Liver Glycogen","D008112","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1971,"5569198","Glycogen degradation and inhibition of enzyme activity in the metamorphosing tadpole hepatocyte.","5569198",193]
["Lysergic Acid Diethylamide","Lysergic Acid Diethylamide","D008238","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1962,"14024487","[Variations in the mortality rate of Rana temporaria tadpoles treated with cortisone acetate, reserpine and methysergide].","14024487",193]
["Malathion","Malathion","D008294","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,2001,"11351406","Effects of malathion on survival, growth, development, and equilibrium posture of bullfrog tadpoles (Rana catesbeiana).","11351406",193]
["Malathion","Malathion","D008294","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,2011,"20556601","Differential effects of malathion and nitrate exposure on American Toad and Wood Frog tadpoles.","20556601",193]
["Malathion","Malathion","D008294","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2008,"18260698","Examining the single and interactive effects of three insecticides on amphibian metamorphosis.","18260698",193]
["Malathion","Malathion","D008294","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,2008,"18839767","An unforeseen chain of events: lethal effects of pesticides on frogs at sublethal concentrations.","18839767",193]
["Malathion","Malathion","D008294","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2009,"18937534","Single and interactive effects of malathion, overwintered green frog tadpoles, and cyanobacteria on gray treefrog tadpoles.","18937534",193]
["Malathion","Malathion","D008294","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2011,"20556601","Differential effects of malathion and nitrate exposure on American Toad and Wood Frog tadpoles.","20556601",193]
["Malathion","Malathion","D008294","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2010,"20931609","Growth, abnormalities, and mortality of tadpoles of American toad exposed to combinations of malathion and nitrate.","20931609",193]
["Malathion","Malathion","D008294","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2012,"22251205","Effects of combinations of malathion and cypermethrin on survivability and time of metamorphosis of tadpoles of Indian cricket frog (Fejervarya limnocharis).","22251205",193]
["Malathion","Malathion","D008294","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2014,"25099070","Effects of amphibian chytrid fungus exposure on American toads in the presence of an insecticide.","25099070",193]
["Malathion","Malathion","D008294","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2017,"27982495","Variation in malathion sensitivity among populations of Blanchard's cricket frogs (Acris blanchardi) and implications for risk assessment.","27982495",193]
["Materia Medica","Materia Medica","D008419","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,2014,"25095334","[Research on therapeutic effects of bufonis venenum on L7212 leukemia and its mechanism].","25095334",193]
["Materia Medica","Materia Medica","D008419","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2007,"18219210","Pretreatment with thyroxin 10(-8) and the effect of homeopathically prepared thyroxin 10(-30) on highland frogs--a multi-researcher study.","18219210",193]
["Materia Medica","Materia Medica","D008419","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2008,"18454254","Treatment of highland frogs from the two-legged stage with homeopathically prepared thyroxin (10-11 - 10-21).","18454254",193]
["Materia Medica","Materia Medica","D008419","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2016,"27473546","A morphometric and molecular study of the apoptosis observed on tadpoles' tail explants under the exposition of triiodothyronine in different homeopathic dilutions.","27473546",193]
["Mechlorethamine","Mechlorethamine","D008466","1_MIE",1156,1,"Dual oxidase","Inhibition","Dual Oxidases","D000074623","Dual Oxidases",2,2,2014,"24164541","Role of nicotinamide adenine dinucleotide phosphate oxidase in mediating vesicant-induced interleukin-6 secretion in human airway epithelial cells.","24164541",193]
["mefenacet","mefenacet","C425686","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2013,"23597675","Application of an amphibian (Silurana tropicalis) metamorphosis assay to the testing of the chronic toxicity of three rice paddy herbicides: simetryn, mefenacet, and thiobencarb.","23597675",193]
["Melengestrol Acetate","Melengestrol Acetate","D008552","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,2013,"22890510","Effects of 17α-trenbolone and melengestrol acetate on Xenopus laevis growth, development, and survival.","22890510",193]
["Mercaptoethanol","Mercaptoethanol","D008623","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1970,"5449483","Experiments on beta-mercaptoethanol as an inhibitor of neurulation movements in amphibian larvae.","5449483",193]
["Mercaptoethanol","Mercaptoethanol","D008623","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1968,"5707495","Induction and competence in morphogenesis: amphibian lens development from non-lens ectoderm, influenced by mercaptoethanol.","5707495",193]
["Mesalamine","Mesalamine","D019804","1_MIE",1156,1,"Dual oxidase","Inhibition","Dual Oxidases","D000074623","Dual Oxidases",2,2,2014,"24492313","DUOX2 and DUOXA2 form the predominant enzyme system capable of producing the reactive oxygen species H2O2 in active ulcerative colitis and are modulated by 5-aminosalicylic acid.","24492313",193]
["Methane","Methane","D008697","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,2011,"21408074","Methane output of tortoises: its contribution to energy loss related to herbivore body mass.","21408074",193]
["Methane","Methane","D008697","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1965,"14254996","FURTHER ASPECTS OF LYMPHOSARCOMA IN XENOPUS (THE SOUTH AFRICAN CLAWED TOAD).","14254996",193]
["Methimazole","Methimazole","D008713","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2005,"16002479","Progress towards development of an amphibian-based thyroid screening assay using Xenopus laevis. Organismal and thyroidal responses to the model compounds 6-propylthiouracil, methimazole, and thyroxine.","16002479",193]
["Methimazole","Methimazole","D008713","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2010,"20821516","Evaluation of the amphibian metamorphosis assay: exposure to the goitrogen methimazole and the endogenous thyroid hormone L-thyroxine.","20821516",193]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C387,B387)","v":"Methimazole"},"Methimazole","D008713","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,2005,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q387,Q387)","v":"16002479"},"Progress towards development of an amphibian-based thyroid screening assay using Xenopus laevis. Organismal and thyroidal responses to the model compounds 6-propylthiouracil, methimazole, and thyroxine.","16002479",193]
["Methimazole","Methimazole","D008713","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,2010,"20530234","Inhibition of thyroid hormone release from cultured amphibian thyroid glands by methimazole, 6-propylthiouracil, and perchlorate.","20530234",193]
["Methimazole","Methimazole","D008713","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,2010,"20821516","Evaluation of the amphibian metamorphosis assay: exposure to the goitrogen methimazole and the endogenous thyroid hormone L-thyroxine.","20821516",193]
["Methimazole","Methimazole","D008713","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,1974,"4546831","Independence of ovarian masculinization and hypothyroidism in frog tadpoles after methimazole treatment.","4546831",193]
["Methoxychlor","Methoxychlor","D008731","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2004,"15310854","Effect of methoxychlor on various life stages of Xenopus laevis.","15310854",193]
["Methoxychlor","Methoxychlor","D008731","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,1,2004,"15272137","Evaluation of the developmental and reproductive toxicity of methoxychlor using an anuran (Xenopus tropicalis) chronic exposure model.","15272137",193]
["Methoxyflurane","Methoxyflurane","D008733","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,1974,"4368913","Methoxyflurane anesthesia for Rana pipiens.","4368913",193]
["Methylcholanthrene","Methylcholanthrene","D008748","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1970,"5416715","Evaluation of the response of Bufo arenarum larvae to 20-methylcholanthrene.","5416715",193]
["Methylene Blue","Methylene Blue","D008751","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1972,"4537678","The production and prophylaxis of calculi in Rana pipiens.","4537678",193]
["Methylthiouracil","Methylthiouracil","D008779","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,1965,"5863654","[Anti-metamorphogenic action of a polypeptide extracted from the pineal gland].","5863654",193]
["Methylthiouracil","Methylthiouracil","D008779","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,1971,"5087959","On the activating effect of prolactin on thyroid metabolism in the crested newt. Comparison between the effect of prolactin and methylthiouracil.","5087959",193]
["Methysergide","Methysergide","D008784","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1962,"14024487","[Variations in the mortality rate of Rana temporaria tadpoles treated with cortisone acetate, reserpine and methysergide].","14024487",193]
["Mifepristone","Mifepristone","D015735","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1997,"9299061","In vitro studies of spontaneous and corticosteroid-induced apoptosis of lymphocyte populations from metamorphosing frogs/RU486 inhibition.","9299061",193]
["Mifepristone","Mifepristone","D015735","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,1997,"9587715","Involvement of glucocorticoids in the reorganization of the amphibian immune system at metamorphosis.","9587715",193]
["monobutyl phthalate","monobutyl phthalate","C028577","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,2011,"21544203","Thyroid disruption by Di-n-butyl phthalate (DBP) and mono-n-butyl phthalate (MBP) in Xenopus laevis.","21544203",193]
["monogalactosyldiacylglycerol","monogalactosyldiacylglycerol","C009909","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1983,"6630186","Changes in nervous system glycolipids during metamorphosis of Xenopus laevis.","6630186",193]
["monomethyl phthalate","monomethyl phthalate","C517284","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,2015,"25662408","Chronic exposures to monomethyl phthalate in Western clawed frogs.","25662408",193]
["N-(2-guanidinoethyl)-5-isoquinolinesulfonamide","N-(2-guanidinoethyl)-5-isoquinolinesulfonamide","C043204","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,1992,"1398014","Inhibition of protein kinase C antagonizes in vitro tadpole tail fin regression induced by thyroxine.","1398014",193]
["N-Acetylneuraminic Acid","N-Acetylneuraminic Acid","D019158","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,2013,"22972462","Total sialic acid profile in regressing and remodelling organs during the metamorphosis of marsh frog (Pelophylax ridibundus Pallas 1771).","22972462",193]
["Nicotine","Nicotine","D009538","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1952,"12998222","[Inhibitory effect of nicotine on metamorphosis induced by thyroxin in tadpoles].","12998222",193]
["Nicotine","Nicotine","D009538","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,2010,"20080209","Nicotine elicits a developmentally dependent depression in bullfrog neuroventilatory response to CO(2).","20080209",193]
["Nifedipine","Nifedipine","D009543","6_AO",1101,6,"Amphibian metamorphosis","Altered",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J408,K408)","v":"Body Weight"},"D001835","Body Weight",1,2,1987,"2453191","[Effect of nifedipine on the cationic profile of myocardium and skeletal muscle of normal and hypertensive rats].","2453191",193]
["Nitric Oxide","Nitric Oxide","D009569","1_MIE",1156,1,"Dual oxidase","Inhibition","Dual Oxidases","D000074623","Dual Oxidases",2,2,2006,"16478776","Expression of TPO and ThOXs in human thyrocytes is downregulated by IL-1alpha/IFN-gamma, an effect partially mediated by nitric oxide.","16478776",193]
["Nitric Oxide","Nitric Oxide","D009569","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,2001,"11494261","Spatiotemporal pattern of nicotinamide adenine dinucleotide phosphate-diaphorase reactivity in the developing central nervous system of premetamorphic Xenopus laevis tadpoles.","11494261",193]
["Nitric Oxide","Nitric Oxide","D009569","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,2004,"15065117","Nitric oxide synthase expression and cell changes in dorsal root ganglia and spinal dorsal horn of developing and adult Rana esculenta indicate a role of nitric oxide in limb metamorphosis.","15065117",193]
["Nitric Oxide","Nitric Oxide","D009569","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,2005,"16023875","Nitric oxide changes its role as a modulator of respiratory motor activity during development in the bullfrog (Rana catesbeiana).","16023875",193]
["Nitrovin","Nitrovin","D009610","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,1980,"6967659","[Studies on the metaboic effects of growth promoters, using nitrovin as model. 3. Effect of growth promoters on the intermediary metabolism as evidenced by the tadpole-test].","6967659",193]
["nonylphenol","nonylphenol","C025256","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2005,"15805048","Effects of nonylphenol on rates of tail resorption and metamorphosis in Rana catesbeiana tadpoles.","15805048",193]
["nonylphenol","nonylphenol","C025256","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2005,"16402308","Endocrine-disrupting effects of nonylphenol, bisphenol A, and p,p'-DDE on Rana nigromaculata tadpoles.","16402308",193]
["nonylphenol","nonylphenol","C025256","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2010,"20870264","Effects of nonylphenol on early embryonic development, pigmentation and 3,5,3'-triiodothyronine-induced metamorphosis in Bombina orientalis (Amphibia: Anura).","20870264",193]
["Norepinephrine","Norepinephrine","D009638","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,1970,"5473788","Studies on myocardial catecholamines related to species ages and sex.","5473788",193]
["Norepinephrine","Norepinephrine","D009638","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,2006,"16943508","Noradrenergic modulation of respiratory motor output during tadpole development: Role of alpha-adrenoceptors.","16943508",193]
["Norepinephrine","Norepinephrine","D009638","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2009,"19176825","Opposing aminergic modulation of distinct spinal locomotor circuits and their functional coupling during amphibian metamorphosis.","19176825",193]
["Norepinephrine","Norepinephrine","D009638","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,2012,"22652878","A switch in aminergic modulation of locomotor CPG output during amphibian metamorphosis.","22652878",193]
["Norepinephrine","Norepinephrine","D009638","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1977,"411709","Catecholamine-secreting cells in the adrenal gland of Bufo bufo during metamorphosis and in the adult.","411709",193]
["Norethindrone","Norethindrone","D009640","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2017,"29268119","The progestin norethisterone affects thyroid hormone-dependent metamorphosis of Xenopus laevis tadpoles at environmentally relevant concentrations.","29268119",193]
["Norethindrone","Norethindrone","D009640","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,2017,"29268119","The progestin norethisterone affects thyroid hormone-dependent metamorphosis of Xenopus laevis tadpoles at environmentally relevant concentrations.","29268119",193]
["novaluron","novaluron","C471805","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2010,"20186694","Developmental disruptions induced by insect growth regulator (Novaluron) in Bufo melanostictus tadpoles.","20186694",193]
["Octopamine","Octopamine","D009655","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,1,1972,"4333325","Distribution and turnover of octopamine in tissues.","4333325",193]
["Oleandomycin","Oleandomycin","D009827","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,1968,"5720232","[On the pharmacology of olemorphocycline].","5720232",193]
["Orotic Acid","Orotic Acid","D009963","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1964,"14209953","PATHWAY OF PYRIMIDINE BIOSYNTHESIS IN PREMETAMORPHIC TADPOLES.","14209953",193]
["Orotic Acid","Orotic Acid","D009963","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1964,"14209954","URACIL METABOLISM IN TADPOLES DURING THYROXINE-INDUCED METAMORPHOSIS.","14209954",193]
["Orotic Acid","Orotic Acid","D009963","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1965,"5885849","Turnover of nuclear and cytoplasmic ribonucleic acid at the onset of induced amphibian metamorphosis.","5885849",193]
["Ouabain","Ouabain","D010042","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1987,"2820249","Ouabain binding in tadpole ventral skin. I. Kinetics and effect on intracellular ions.","2820249",193]
["Ouabain","Ouabain","D010042","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1987,"2820250","Ouabain binding in tadpole ventral skin. II. Localization of Na pump sites.","2820250",193]
["oxaliplatin","oxaliplatin","C030110","1_MIE",1156,1,"Dual oxidase","Inhibition","Dual Oxidases","D000074623","Dual Oxidases",2,2,2016,"26719345","Role of Reactive Oxygen Species in the Abrogation of Oxaliplatin Activity by Cetuximab in Colorectal Cancer.","26719345",193]
["Oxidopamine","Oxidopamine","D016627","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,1983,"6140118","6-Hydroxydopamine produces a weight increase in toads.","6140118",193]
["Ozone","Ozone","D010126","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,2001,"11453678","Effects of ozone on evaporative water loss and thermoregulatory behavior of marine toads (Bufo marinus).","11453678",193]
["pentabromodiphenyl ether","pentabromodiphenyl ether","C086401","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2017,"27228472","Warmer temperature modifies effects of polybrominated diphenyl ethers on hormone profiles in leopard frog tadpoles (Lithobates pipiens).","27228472",193]
["Pentobarbital","Pentobarbital","D010424","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,1974,"4415330","Prolactin-releasing effects of centrally-acting drugs in the red-spotted newt, Notophthalmus viridescens.","4415330",193]
["perchlorate","perchlorate","C494474","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2009,"19387088","Thyroid histopathology assessments for the amphibian metamorphosis assay to detect thyroid-active substances.","19387088",193]
["perchlorate","perchlorate","C494474","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2010,"19913875","Surface water mitigates the anti-metamorphic effects of perchlorate in New Mexico spadefoot toads (Spea multiplicata) and African clawed frogs (Xenopus laevis).","19913875",193]
["perchlorate","perchlorate","C494474","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,2015,"25448256","Changes in gastric sodium-iodide symporter (NIS) activity are associated with differences in thyroid gland sensitivity to perchlorate during metamorphosis.","25448256",193]
["perchlorate","perchlorate","C494474","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2018,"29482025","Lifecycle exposure to perchlorate differentially alters morphology, biochemistry, and transcription as well as sperm motility in Silurana tropicalis frogs.","29482025",193]
["perchlorate","perchlorate","C494474","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,2006,"16341611","Thyroid endocrine disruption in stonerollers and cricket frogs from perchlorate-contaminated streams in east-central Texas.","16341611",193]
["perchlorate","perchlorate","C494474","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,2006,"16807283","The colloidal thyroxine (T4) ring as a novel biomarker of perchlorate exposure in the African clawed frog Xenopus laevis.","16807283",193]
["perchlorate","perchlorate","C494474","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,1,2008,"18275962","A perchlorate sensitive iodide transporter in frogs.","18275962",193]
["perchlorate","perchlorate","C494474","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,2009,"18801409","Perchlorate and ethylenethiourea induce different histological and molecular alterations in a non-mammalian vertebrate model of thyroid goitrogenesis.","18801409",193]
["perchlorate","perchlorate","C494474","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,2009,"19387088","Thyroid histopathology assessments for the amphibian metamorphosis assay to detect thyroid-active substances.","19387088",193]
["perchlorate","perchlorate","C494474","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,2010,"20530234","Inhibition of thyroid hormone release from cultured amphibian thyroid glands by methimazole, 6-propylthiouracil, and perchlorate.","20530234",193]
["perchlorate","perchlorate","C494474","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,1,2015,"25448256","Changes in gastric sodium-iodide symporter (NIS) activity are associated with differences in thyroid gland sensitivity to perchlorate during metamorphosis.","25448256",193]
["perchlorate","perchlorate","C494474","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,1,2018,"29482025","Lifecycle exposure to perchlorate differentially alters morphology, biochemistry, and transcription as well as sperm motility in Silurana tropicalis frogs.","29482025",193]
["perfluorooctane sulfonic acid","perfluorooctane sulfonic acid","C076994","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,2004,"15559291","Partial life-cycle toxicity and bioconcentration modeling of perfluorooctanesulfonate in the northern leopard frog (Rana pipiens).","15559291",193]
["perfluorooctane sulfonic acid","perfluorooctane sulfonic acid","C076994","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2004,"15559291","Partial life-cycle toxicity and bioconcentration modeling of perfluorooctanesulfonate in the northern leopard frog (Rana pipiens).","15559291",193]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C451,B451)","v":"perfluorooctane sulfonic acid"},"perfluorooctane sulfonic acid","C076994","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2011,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q451,Q451)","v":"21809121"},"Thyroid disruption effects of environmental level perfluorooctane sulfonates (PFOS) in Xenopus laevis.","21809121",193]
["perfluorooctane sulfonic acid","perfluorooctane sulfonic acid","C076994","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,2004,"15559291","Partial life-cycle toxicity and bioconcentration modeling of perfluorooctanesulfonate in the northern leopard frog (Rana pipiens).","15559291",193]
["perfluorooctane sulfonic acid","perfluorooctane sulfonic acid","C076994","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,2011,"21809121","Thyroid disruption effects of environmental level perfluorooctane sulfonates (PFOS) in Xenopus laevis.","21809121",193]
["Permethrin","Permethrin","D026023","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2008,"18260698","Examining the single and interactive effects of three insecticides on amphibian metamorphosis.","18260698",193]
["Phenobarbital","Phenobarbital","D010634","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1998,"9535735","Induction of hepatic cytochrome P-450 by phenobarbital in semi-aquatic frog (Rana pipiens).","9535735",193]
["Phenylthiourea","Phenylthiourea","D010670","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,1967,"4963658","Effect of phenylthiourea upon posterior hypothalectomized tadpoles of Rana pipiens.","4963658",193]
["phosalone","phosalone","C003117","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,1989,"2480092","Blood carbohydrates and phosalone poisoning in Rana tigrina (Daudin).","2480092",193]
["Pilocarpine","Pilocarpine","D010862","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,1997,"9502523","The effect of posterior lobe extract, adrenalin, and pilocarpine on the response of the thyroid gland to the thyreoactivator hormone of the anterior lobe of the hypophysis.","9502523",193]
["pioglitazone","pioglitazone","C060836","1_MIE",1156,1,"Dual oxidase","Inhibition","Dual Oxidases","D000074623","Dual Oxidases",2,2,2016,"27324467","Pioglitazone, a PPARγ Agonist, Upregulates the Expression of Caveolin-1 and Catalase, Essential for Thyroid Cell Homeostasis: A Clue to the Pathogenesis of Hashimoto's Thyroiditis.","27324467",193]
["PKH 26","PKH 26","C070080","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1999,"10545036","Rapid and selective removal of larval erythrocytes from systemic circulation during metamorphosis of the bullfrog, Rana catesbeiana.","10545036",193]
["poly(3,4-ethylene dioxythiophene)","poly(3,4-ethylene dioxythiophene)","C121383","1_MIE",1156,1,"Dual oxidase","Inhibition","Dual Oxidases","D000074623","Dual Oxidases",2,2,2012,"22944870","Directed differentiation of embryonic P19 cells and neural stem cells into neural lineage on conducting PEDOT-PEG and ITO glass substrates.","22944870",193]
["polysialic acid","polysialic acid","C021319","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1993,"8245224","Amphibian-specific regulation of polysialic acid and the neural cell adhesion molecule in development and regeneration of the retinotectal system of the salamander Pleurodeles waltl.","8245224",193]
["porphyropsin","porphyropsin","C010507","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1957,"13439167","The metamorphosis of visual systems in the sea lamprey.","13439167",193]
["potassium perchlorate","potassium perchlorate","C009006","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2007,"17657452","Alteration of larval development and metamorphosis by nitrate and perchlorate in southern leopard frogs (Rana sphenocephala).","17657452",193]
["potassium perchlorate","potassium perchlorate","C009006","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1997,"9467928","Immunocytochemical distribution of corticotropin-releasing factor in the brain and hypophysis of larval Bufo arenarum; effect of KClO4 during early development.","9467928",193]
["potassium perchlorate","potassium perchlorate","C009006","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,2007,"17657452","Alteration of larval development and metamorphosis by nitrate and perchlorate in southern leopard frogs (Rana sphenocephala).","17657452",193]
["potassium perchlorate","potassium perchlorate","C009006","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,1996,"8916461","Ultrastructural study on thyroid glands of Bufo arenarum larvae kept in potassium perchlorate solution.","8916461",193]
["PQQ Cofactor","PQQ Cofactor","D045542","1_MIE",1156,1,"Dual oxidase","Inhibition","Dual Oxidases","D000074623","Dual Oxidases",2,2,2017,"28676501","Lifespan extension by peroxidase and dual oxidase-mediated ROS signaling through pyrroloquinoline quinone in C. elegans.","28676501",193]
["Prednisolone","Prednisolone","D011239","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,1959,"13651451","[The thyroid in Rana esculenta tadpoles treated with massive doses of estradiol &amp; meticortelone].","13651451",193]
["propionic acid","propionic acid","C029658","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1955,"13277261","[Action of 3, 5 diiodo-4-(3'5' diiodo-4-hydroxyphenoxy) phenyl-propionic acid on the metamorphosis of Rana temporaria tadpoles].","13277261",193]
["Propylthiouracil","Propylthiouracil","D011441","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2005,"16002479","Progress towards development of an amphibian-based thyroid screening assay using Xenopus laevis. Organismal and thyroidal responses to the model compounds 6-propylthiouracil, methimazole, and thyroxine.","16002479",193]
["Propylthiouracil","Propylthiouracil","D011441","6_AO",1101,6,"Amphibian metamorphosis","Altered",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J472,K472)","v":"Metamorphosis, Biological"},"D008675","Metamorphosis, Biological",2,4,2007,"17339059","The impact of the goitrogen 6-propylthiouracil (PTU) on West-African clawed frog (Xenopus tropicalis) exposed during metamorphosis.","17339059",193]
["Propylthiouracil","Propylthiouracil","D011441","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2012,"23067544","Examination of an amphibian metamorphosis assay under an individual-separated exposure system using Silurana tropicalis tadpoles.","23067544",193]
["Propylthiouracil","Propylthiouracil","D011441","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,1987,"3436400","The effect of chemically produced shifts in developmental timing on postmetamorphic morphology in Bombina orientalis.","3436400",193]
["Propylthiouracil","Propylthiouracil","D011441","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1985,"3973094","Regulation of neuron numbers in Xenopus laevis: effects of hormonal manipulation altering size at metamorphosis.","3973094",193]
["Propylthiouracil","Propylthiouracil","D011441","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,1969,"4100800","[Action of goitrogens on tadpoles of the toad, Bufo bufo L].","4100800",193]
["Propylthiouracil","Propylthiouracil","D011441","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1968,"4179072","Hypothalamic neurosecretion and metamorphosis in Xenopus laevis. I. The effect of propylthiouracil.","4179072",193]
["Propylthiouracil","Propylthiouracil","D011441","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,1968,"4183637","Hypothalamic neurosecretion and metamorphosis in Xenopus laevis. 3. The effect of an interruption of thyroid hormone synthesis.","4183637",193]
["Propylthiouracil","Propylthiouracil","D011441","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,1969,"4190327","Hypothalamic neurosecretion and metamorphosis in Xenopus laevis. IV. The effect of extirpation of the presumed TRF cells and of a subsequent PTU treatment.","4190327",193]
["Propylthiouracil","Propylthiouracil","D011441","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1972,"4629898","[Ultrastructure of the adenohypophysis in the toad Bufo bufo L. IV. Modifications of the larval pars distalis after treatment with PTU].","4629898",193]
["Propylthiouracil","Propylthiouracil","D011441","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1973,"4753365","Effects of pituitary hormones, melatonin, and thyroidal inhibitors on radioiodide uptake by the thyroid glands of larval and adult tiger salamanders, Ambystoma tigrinum (Amphibia: Caudata).","4753365",193]
["Propylthiouracil","Propylthiouracil","D011441","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,1968,"4905268","Hypothalamic neurosecretion and metamorphosis in Xenopus laevis. II. The effect of thyroxine following treatment with propylthiouracil.","4905268",193]
["Propylthiouracil","Propylthiouracil","D011441","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,1970,"5489020","Prolactin--thyroid interaction in the newt, Diemictylus viridescens.","5489020",193]
["Propylthiouracil","Propylthiouracil","D011441","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,1981,"7227631","Patterns of protein synthesis in livers of Xenopus laevis during metamorphosis: effects of estrogen in normal and thyrostatic animals.","7227631",193]
["Propylthiouracil","Propylthiouracil","D011441","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,2005,"16002479","Progress towards development of an amphibian-based thyroid screening assay using Xenopus laevis. Organismal and thyroidal responses to the model compounds 6-propylthiouracil, methimazole, and thyroxine.","16002479",193]
["Propylthiouracil","Propylthiouracil","D011441","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,2007,"17339059","The impact of the goitrogen 6-propylthiouracil (PTU) on West-African clawed frog (Xenopus tropicalis) exposed during metamorphosis.","17339059",193]
["Propylthiouracil","Propylthiouracil","D011441","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,2010,"20530234","Inhibition of thyroid hormone release from cultured amphibian thyroid glands by methimazole, 6-propylthiouracil, and perchlorate.","20530234",193]
["Propylthiouracil","Propylthiouracil","D011441","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,2011,"21963960","Integument structure and function in juvenile Xenopus laevis with disrupted thyroid balance.","21963960",193]
["Propylthiouracil","Propylthiouracil","D011441","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,2012,"23067544","Examination of an amphibian metamorphosis assay under an individual-separated exposure system using Silurana tropicalis tadpoles.","23067544",193]
["Propylthiouracil","Propylthiouracil","D011441","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,1969,"4100800","[Action of goitrogens on tadpoles of the toad, Bufo bufo L].","4100800",193]
["Propylthiouracil","Propylthiouracil","D011441","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,1968,"4179072","Hypothalamic neurosecretion and metamorphosis in Xenopus laevis. I. The effect of propylthiouracil.","4179072",193]
["Propylthiouracil","Propylthiouracil","D011441","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,1968,"4183637","Hypothalamic neurosecretion and metamorphosis in Xenopus laevis. 3. The effect of an interruption of thyroid hormone synthesis.","4183637",193]
["Propylthiouracil","Propylthiouracil","D011441","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,1969,"4190327","Hypothalamic neurosecretion and metamorphosis in Xenopus laevis. IV. The effect of extirpation of the presumed TRF cells and of a subsequent PTU treatment.","4190327",193]
["Propylthiouracil","Propylthiouracil","D011441","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,1,1972,"4629898","[Ultrastructure of the adenohypophysis in the toad Bufo bufo L. IV. Modifications of the larval pars distalis after treatment with PTU].","4629898",193]
["Propylthiouracil","Propylthiouracil","D011441","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,1973,"4753365","Effects of pituitary hormones, melatonin, and thyroidal inhibitors on radioiodide uptake by the thyroid glands of larval and adult tiger salamanders, Ambystoma tigrinum (Amphibia: Caudata).","4753365",193]
["Propylthiouracil","Propylthiouracil","D011441","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,1968,"4905268","Hypothalamic neurosecretion and metamorphosis in Xenopus laevis. II. The effect of thyroxine following treatment with propylthiouracil.","4905268",193]
["Propylthiouracil","Propylthiouracil","D011441","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,1,1981,"7227631","Patterns of protein synthesis in livers of Xenopus laevis during metamorphosis: effects of estrogen in normal and thyrostatic animals.","7227631",193]
["Prostaglandins E","Prostaglandins E","D011458","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1988,"3164274","Prostaglandin E2 does not inhibit metamorphosis of tadpole tails in tissue culture.","3164274",193]
["pterorhodin","pterorhodin","C017688","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,2003,"12950730","Enigmas of pterorhodin, a red melanosomal pigment of tree frogs.","12950730",193]
["pterorhodin","pterorhodin","C017688","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1982,"7066990","Electron microscopic study of leaf frog melanophore differentiation in culture, with special reference to allopurinol effect on pterorhodin formation.","7066990",193]
["pterorhodin","pterorhodin","C017688","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1980,"7379129","The differentiation of leaf frog melanophores in culture.","7379129",193]
["Pyocyanine","Pyocyanine","D011710","1_MIE",1156,1,"Dual oxidase","Inhibition","Dual Oxidases","D000074623","Dual Oxidases",2,4,2008,"18802092","The Pseudomonas toxin pyocyanin inhibits the dual oxidase-based antimicrobial system as it imposes oxidative stress on airway epithelial cells.","18802092",193]
["pyrachlostrobin","pyrachlostrobin","C513428","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,2014,"24522617","Chronic effects of strobilurin fungicides on development, growth, and mortality of larval Great Plains toads (Bufo cognatus).","24522617",193]
["pyrachlostrobin","pyrachlostrobin","C513428","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2014,"24522617","Chronic effects of strobilurin fungicides on development, growth, and mortality of larval Great Plains toads (Bufo cognatus).","24522617",193]
["pyrimethanil","pyrimethanil","C108337","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2016,"26771902","Effects of long-term exposure to two fungicides, pyrimethanil and tebuconazole, on survival and life history traits of Italian tree frog (Hyla intermedia).","26771902",193]
["pyrimidine","pyrimidine","C030986","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1964,"14209953","PATHWAY OF PYRIMIDINE BIOSYNTHESIS IN PREMETAMORPHIC TADPOLES.","14209953",193]
["Quilt","Quilt","C000597676","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,2014,"24522617","Chronic effects of strobilurin fungicides on development, growth, and mortality of larval Great Plains toads (Bufo cognatus).","24522617",193]
["Quilt","Quilt","C000597676","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2014,"24522617","Chronic effects of strobilurin fungicides on development, growth, and mortality of larval Great Plains toads (Bufo cognatus).","24522617",193]
["Radioactive Fallout","Radioactive Fallout","D011847","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,1999,"10049928","Genome reduction in a hemiclonal frog Rana esculenta from radioactively contaminated areas.","10049928",193]
["Radioactive Fallout","Radioactive Fallout","D011847","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,2003,"12948907","Disrupting a delicate balance: environmental effects on the thyroid.","12948907",193]
["Reserpine","Reserpine","D012110","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1960,"13752189","[Action of reserpine on the metamorphosis of tadpoles of Rana temporaria].","13752189",193]
["Reserpine","Reserpine","D012110","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1962,"14024487","[Variations in the mortality rate of Rana temporaria tadpoles treated with cortisone acetate, reserpine and methysergide].","14024487",193]
["Reserpine","Reserpine","D012110","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1961,"14454834","[Comparative action of reserpine, chlorpromazine and serotonin on the metamorphosis of the tadpole of Rana temporaria].","14454834",193]
["Reserpine","Reserpine","D012110","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,1974,"4415330","Prolactin-releasing effects of centrally-acting drugs in the red-spotted newt, Notophthalmus viridescens.","4415330",193]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C515,B515)","v":"Reserpine"},"Reserpine","D012110","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,1979,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q515,Q515)","v":"583463"},"Effects of ergocornine and reserpine on metamorphosis in Bufo bufo japonicus tadpoles.","583463",193]
["retinol palmitate","retinol palmitate","C014794","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1988,"3401522","Vitamin A induced bilateral asymmetries in triturus forelimb regenerates.","3401522",193]
["Riboflavin","Riboflavin","D012256","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1974,"4449576","Riboflavin as \"pigment\" in the skin of Proteus anguinus L.","4449576",193]
["roscovitine","roscovitine","C104586","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2008,"19035345","Roscovitine inhibits thyroid hormone-induced tail regression of the frog tadpole and reveals a role for cyclin C/Cdk8 in the establishment of the metamorphic gene expression program.","19035345",193]
["royal jelly","royal jelly","C058787","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1956,"13404044","[Effect of royal jelly on the development and on the metamorphosis of tadpoles of Bufo vulgaris].","13404044",193]
["Ruthenium Red","Ruthenium Red","D012430","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1976,"978162","Muscle satellite cells in urodele amphibians: faciliatated identification of satellite cells using ruthenium red staining.","978162",193]
["Serotonin","Serotonin","D012701","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,1999,"10398886","Neurohormonal peptides, serotonin, and nitric oxide synthase in the enteric nervous system and endocrine cells of the gastrointestinal tract of neotenic and thyroid hormone-treated axolotls (Ambystoma mexicanum).","10398886",193]
["Serotonin","Serotonin","D012701","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,2002,"12425975","Role of 5-HT2A/C receptors in serotonergic modulation of respiratory motor output during tadpole development.","12425975",193]
["Serotonin","Serotonin","D012701","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1964,"14227353","GRANULAR GLAND DEVELOPMENT DURING XENOPUS LAEVIS METAMORPHOSIS.","14227353",193]
["Serotonin","Serotonin","D012701","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1961,"14454834","[Comparative action of reserpine, chlorpromazine and serotonin on the metamorphosis of the tadpole of Rana temporaria].","14454834",193]
["Serotonin","Serotonin","D012701","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,2005,"16151854","Ontogeny of central serotonergic neurons in the directly developing frog, Eleutherodactylus coqui.","16151854",193]
["Serotonin","Serotonin","D012701","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,2007,"17562878","Effects of medullary Raphé stimulation on fictive lung ventilation during development in Rana catesbeiana.","17562878",193]
["Serotonin","Serotonin","D012701","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2009,"19176825","Opposing aminergic modulation of distinct spinal locomotor circuits and their functional coupling during amphibian metamorphosis.","19176825",193]
["Serotonin","Serotonin","D012701","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,2012,"22652878","A switch in aminergic modulation of locomotor CPG output during amphibian metamorphosis.","22652878",193]
["Serotonin","Serotonin","D012701","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2013,"23383055","Developmental exposure to fluoxetine modulates the serotonin system in hypothalamus.","23383055",193]
["Serotonin","Serotonin","D012701","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1989,"2692831","Development of Xenopus laevis skin glands producing 5-hydroxytryptamine and caerulein.","2692831",193]
["Serotonin","Serotonin","D012701","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1969,"5813225","The occurrence of enterochromaffin cells in tadpoles and juveniles of Xenopus laevis, with special reference to 5-hydroxytryptamine and its possible roles in metamorphosis.","5813225",193]
["Serotonin","Serotonin","D012701","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1965,"5899517","Changing serotonin levels in developing Xenopus laevis.","5899517",193]
["Serotonin","Serotonin","D012701","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1993,"7906699","Serotonin-like immunoreactivity in the adult and developing retina of the leopard frog Rana pipiens.","7906699",193]
["Serotonin","Serotonin","D012701","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1994,"8090792","Modulation of rhythmic swimming activity in post-embryonic Xenopus laevis tadpoles by 5-hydroxytryptamine acting at 5HT1a receptors.","8090792",193]
["Serotonin","Serotonin","D012701","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,2013,"23383055","Developmental exposure to fluoxetine modulates the serotonin system in hypothalamus.","23383055",193]
["Sertraline","Sertraline","D020280","6_AO",1101,6,"Amphibian metamorphosis","Altered",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J536,K536)","v":"Metamorphosis, Biological"},"D008675","Metamorphosis, Biological",2,4,2009,"19572769","Growth and development of tadpoles (Xenopus laevis) exposed to selective serotonin reuptake inhibitors, fluoxetine and sertraline, throughout metamorphosis.","19572769",193]
["Sewage","Sewage","D012722","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,2003,"12963404","Endocrine effects of environmental pollution on Xenopus laevis and Rana temporaria.","12963404",193]
["Simazine","Simazine","D012839","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2016,"27485009","Continued Studies on the Effects of Simazine on the Liver Histological Structure and Metamorphosis in the Developing Xenopus laevis.","27485009",193]
["simetryn","simetryn","C033807","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2013,"23597675","Application of an amphibian (Silurana tropicalis) metamorphosis assay to the testing of the chronic toxicity of three rice paddy herbicides: simetryn, mefenacet, and thiobencarb.","23597675",193]
["sodium arsenite","sodium arsenite","C017947","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2014,"25048924","Sodium arsenite induced changes in survival, growth, metamorphosis and genotoxicity in the Indian cricket frog (Rana limnocharis).","25048924",193]
["Sodium Chloride","Sodium Chloride","D012965","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,1963,"14109735","OSMOTIC AND IONIC REGULATION IN AMBYSTOMA TIGRINUM.","14109735",193]
["Sodium Chloride","Sodium Chloride","D012965","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,1987,"3305152","Water uptake by Rana temporaria: effects of diuretics and the renin--angiotensin system, and nephrectomy.","3305152",193]
["Sodium Chloride","Sodium Chloride","D012965","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,1973,"4200188","Studies on the adaptation of the toad Bufo viridis to high salinities: oxygen consumption, plasma concentration and water content of the tissues.","4200188",193]
["Sodium Chloride","Sodium Chloride","D012965","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,1976,"6202","Tricaine methanesulfonate--II. Effects on transport of NaCl and H2O.","6202",193]
["Sodium Chloride","Sodium Chloride","D012965","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,1997,"9185343","Salt and water balance in the toad Bufo viridis during recovery from two different osmotically stressful conditions.","9185343",193]
["Sodium Chloride","Sodium Chloride","D012965","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,2006,"16159689","Effects of road de-icing salt (NaCl) on larval wood frogs (Rana sylvatica).","16159689",193]
["Sodium Chloride","Sodium Chloride","D012965","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,2008,"18488630","Impacts of road deicing salt on the demography of vernal pool-breeding amphibians.","18488630",193]
["Sodium Chloride","Sodium Chloride","D012965","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2009,"19663642","Effects of salinity on the survival, growth, development, and metamorphosis of Fejervarya limnocharis tadpoles living in brackish water.","19663642",193]
["Sodium Chloride","Sodium Chloride","D012965","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2013,"23474321","Effects of salinity stress on Bufo balearicus and Bufo bufo tadpoles: Tolerance, morphological gill alterations and Na(+)/K(+)-ATPase localization.","23474321",193]
["Sodium Chloride","Sodium Chloride","D012965","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2015,"26033303","Legacy of road salt: Apparent positive larval effects counteracted by negative postmetamorphic effects in wood frogs.","26033303",193]
["Sodium Chloride","Sodium Chloride","D012965","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1972,"4653167","The effect of thyroxine and hypertonic environment on the enzymes of the urea cycle in Xenopus laevis.","4653167",193]
["Sodium Chloride","Sodium Chloride","D012965","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,1977,"892411","[Hypophyseal and thyroidal modifications in Pleurodeles in saline].","892411",193]
["Sodium Fluoride","Sodium Fluoride","D012969","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1957,"13511845","[Action of sodium fluoride on metamorphosis of the frog].","13511845",193]
["Sodium Fluoride","Sodium Fluoride","D012969","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1961,"13755459","The effect of sodium fluoride on the metamorphosis of tadpoles.","13755459",193]
["sodium nitrate","sodium nitrate","C031618","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,1999,"10475914","Effects of ammonium nitrate, sodium nitrate, and urea on red-legged frogs, Pacific treefrogs, and African clawed frogs.","10475914",193]
["sodium nitrate","sodium nitrate","C031618","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2007,"17657452","Alteration of larval development and metamorphosis by nitrate and perchlorate in southern leopard frogs (Rana sphenocephala).","17657452",193]
["sodium nitrate","sodium nitrate","C031618","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,2007,"17657452","Alteration of larval development and metamorphosis by nitrate and perchlorate in southern leopard frogs (Rana sphenocephala).","17657452",193]
["sodium perchlorate","sodium perchlorate","C031068","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1992,"1320967","Thymus ontogeny in frogs: T-cell renewal at metamorphosis.","1320967",193]
["sodium perchlorate","sodium perchlorate","C031068","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2005,"15839568","Metamorphic inhibition of Xenopus laevis by sodium perchlorate: effects on development and thyroid histology.","15839568",193]
["sodium perchlorate","sodium perchlorate","C031068","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,1990,"1967017","Expression of class II major histocompatibility complex antigens on adult T cells in Xenopus is metamorphosis-dependent.","1967017",193]
["sodium perchlorate","sodium perchlorate","C031068","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,2015,"25623150","Sodium perchlorate disrupts development and affects metamorphosis- and growth-related gene expression in tadpoles of the wood frog (Lithobates sylvaticus).","25623150",193]
["sodium perchlorate","sodium perchlorate","C031068","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1993,"8388813","Effects of thyroid hormone deprivation on immunity in postmetamorphic frogs.","8388813",193]
["sodium perchlorate","sodium perchlorate","C031068","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,1,2003,"12630449","Iodine counteracts perchlorate effects in frogs.","12630449",193]
["sodium perchlorate","sodium perchlorate","C031068","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,2005,"15839568","Metamorphic inhibition of Xenopus laevis by sodium perchlorate: effects on development and thyroid histology.","15839568",193]
["Spermine","Spermine","D013096","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1970,"5269230","Influence of spermine and reduced temperature on the ability of transplanted nuclei to promote normal development in eggs of Rana pipiens.","5269230",193]
["Stratego","Stratego","C556296","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,2014,"24522617","Chronic effects of strobilurin fungicides on development, growth, and mortality of larval Great Plains toads (Bufo cognatus).","24522617",193]
["Stratego","Stratego","C556296","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2014,"24522617","Chronic effects of strobilurin fungicides on development, growth, and mortality of larval Great Plains toads (Bufo cognatus).","24522617",193]
["succinonitrile","succinonitrile","C010337","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1955,"13239824","[Factors of growth and metamorphosis of amphibian larvae. V. Effect of succinonitrile and dimethyldicyanopyrazine].","13239824",193]
["Taurine","Taurine","D013654","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1978,"157672","Effect of Litoralon on the development of goblet cells of the intestinal mucosa during metamorphosis of the frog.","157672",193]
["Taurine","Taurine","D013654","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,2005,"15838590","gamma-L-glutamyltaurine.","15838590",193]
["Taurine","Taurine","D013654","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,1976,"4276","Taurine levels in the anuran tadpole tail during spontaneous and triiodothyronine-induced metamorphosis.","4276",193]
["Taurine","Taurine","D013654","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,1979,"499104","The triiodothyronine antagonistic effect of gamma-L-glutamyl-taurine (litoralon).","499104",193]
["Taurine","Taurine","D013654","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,1980,"7428713","Effect of litoralon (gamma-L-glutamyl-taurine) on the tail involution of tadpoles in vitro.","7428713",193]
["Taurine","Taurine","D013654","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,1979,"94855","The effect of glutaurine on the development of amphibian larvae with inhibited RNA and protein synthesis.","94855",193]
["Taurine","Taurine","D013654","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,1,2005,"15838590","gamma-L-glutamyltaurine.","15838590",193]
["tebuconazole","tebuconazole","C087114","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2016,"26771902","Effects of long-term exposure to two fungicides, pyrimethanil and tebuconazole, on survival and life history traits of Italian tree frog (Hyla intermedia).","26771902",193]
["tetrabromobisphenol A","tetrabromobisphenol A","C020806","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2005,"15680168","Anti-thyroid hormonal activity of tetrabromobisphenol A, a flame retardant, and related compounds: Affinity to the mammalian thyroid hormone receptor, and effect on tadpole metamorphosis.","15680168",193]
["tetrabromobisphenol A","tetrabromobisphenol A","C020806","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2006,"16290818","Effects of tetrabromobisphenol A on larval development and thyroid hormone-regulated biomarkers of the amphibian Xenopus laevis.","16290818",193]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C579,B579)","v":"tetrabromobisphenol A"},"tetrabromobisphenol A","C020806","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2006,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q579,Q579)","v":"16678281"},"Exposure to tetrabromobisphenol-A alters TH-associated gene expression and tadpole metamorphosis in the Pacific tree frog Pseudacris regilla.","16678281",193]
["tetrabromobisphenol A","tetrabromobisphenol A","C020806","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2015,"26257357","A screening assay for thyroid hormone signaling disruption based on thyroid hormone-response gene expression analysis in the frog Pelophylax nigromaculatus.","26257357",193]
["tetrabromobisphenol A","tetrabromobisphenol A","C020806","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,2012,"22968643","Thyroid hormone signaling in the Xenopus laevis embryo is functional and susceptible to endocrine disruption.","22968643",193]
["Tetracycline","Tetracycline","D013752","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,1968,"5720232","[On the pharmacology of olemorphocycline].","5720232",193]
["Tetradecanoylphorbol Acetate","Tetradecanoylphorbol Acetate","D013755","1_MIE",1156,1,"Dual oxidase","Inhibition","Dual Oxidases","D000074623","Dual Oxidases",2,2,2012,"21984036","Regulation of PMA-induced MUC5AC expression by heparin in human bronchial epithelial cells.","21984036",193]
["Tetrodotoxin","Tetrodotoxin","D013779","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2011,"21459104","Tetrodotoxin levels in larval and metamorphosed newts (Taricha granulosa) and palatability to predatory dragonflies.","21459104",193]
["Tetrodotoxin","Tetrodotoxin","D013779","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2015,"25986913","Confirmation of the absence of tetrodotoxin and its analogues in the juveniles of the Japanese fire-bellied newt, Cynops pyrrhogaster, captive-reared from eggs in the laboratory using HILIC-LC-MS.","25986913",193]
["Thalidomide","Thalidomide","D013792","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1964,"14248715","THALIDOMIDE AND INDUCED AMPHIBIAN METAMORPHOSIS.","14248715",193]
["Thalidomide","Thalidomide","D013792","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,1965,"5839215","The effect of thalidomide and its derivatives on thyroxine-induced metamorphosis of tadpole.","5839215",193]
["Theophylline","Theophylline","D013806","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1979,"226453","Effect of lithium chloride and theophylline on hexosaminidase activity in tadpole tail discs.","226453",193]
["thiamethoxam","thiamethoxam","C416660","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2017,"28248437","Sublethal effects on wood frogs chronically exposed to environmentally relevant concentrations of two neonicotinoid insecticides.","28248437",193]
["Thiamine","Thiamine","D013831","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1967,"6075144","Thiamine mono- and diphosphate splitting enzymes in the pre- and postmeamorphic Pelobates syriacus.","6075144",193]
["Thiophanate","Thiophanate","D013875","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2012,"22912890","Unlikely remedy: fungicide clears infection from pathogenic fungus in larval southern leopard frogs (Lithobates sphenocephalus).","22912890",193]
["thiosemicarbazide","thiosemicarbazide","C005151","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,1983,"6842158","Thiosemicarbazide-induced osteolathyrism in metamorphosing Xenopus laevis.","6842158",193]
["Thiouracil","Thiouracil","D013889","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1961,"13732097","Biochemical studies on amphibian metamorphosis. II. The effect of thiouracil on thyroxine-stimulated protein synthesis in tadpole liver.","13732097",193]
["Thiouracil","Thiouracil","D013889","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1972,"5011146","[Differentiation of TSH-cells in Xenopus laevis under normal conditions and after thiouracil-treatment].","5011146",193]
["Thiouracil","Thiouracil","D013889","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,1959,"13650883","[Thyroid, parathyroid &amp; calcium salts in the endolymphatic sac in Bufo bufo bufo tadpoles treated with thiouracil].","13650883",193]
["Thiouracil","Thiouracil","D013889","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,1,1950,"14811108","[Cystic formation in thyroid gland of tadpoles of Discoglossus pictus otth. treated with thiouracil].","14811108",193]
["Thiouracil","Thiouracil","D013889","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,1,1950,"15432736","Effect of thiouracil on uptake of radioactive iodine by thyroid gland of summer frogs (Rana pipiens).","15432736",193]
["Thiourea","Thiourea","D013890","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1965,"14303261","METAMORPHOSIS AND NEUROSECRETION OF XENOPUS LAEVIS. NEUROSECRETORY ACTIVITY OF PRAEOPTIC NUCLEI DURING AND AFTER PROLONGED THIOUREA TREATMENT.","14303261",193]
["Thiourea","Thiourea","D013890","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1962,"14453011","Effect of water-miscible preparation of vitamin D2 on metamorphosis of thiourea and citrate treated Rana pipiens larvae.","14453011",193]
["Thiourea","Thiourea","D013890","6_AO",1101,6,"Amphibian metamorphosis","Altered",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J600,K600)","v":"Metamorphosis, Biological"},"D008675","Metamorphosis, Biological",2,4,2012,"22559962","Metamorphosis inhibition: an alternative rearing protocol for the newt, Cynops pyrrhogaster.","22559962",193]
["Thiourea","Thiourea","D013890","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1949,"24537051","[The effect of sodium salt of 2-thio-6-methyl-uracil on the course of metamorphosis of the tadpoles of Rana temporaria L].","24537051",193]
["Thiourea","Thiourea","D013890","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,1988,"3130597","[Effect of gutimine derivatives on the metamorphosis of Rana temporaria tadpoles].","3130597",193]
["Thiourea","Thiourea","D013890","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,1988,"3133082","Excessive numbers of axons after early enucleation and blockade of metamorphosis in the oculomotor nerve of Xenopus laevis.","3133082",193]
["Thiourea","Thiourea","D013890","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,1971,"5004766","Effect of thyroxine and thiourea on the alkaline and acid phosphatase activity in liver of tadpoles at various stages of development of larval life.","5004766",193]
["Thiourea","Thiourea","D013890","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,1982,"6175427","Effect of thyroid hormones on the switch from larval to adult hemoglobin synthesis in the salamander Pleurodeles waltlii.","6175427",193]
["Thiourea","Thiourea","D013890","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,1,1960,"13768737","[Differential effects of chronic hypothalamic lesions on the thyroid and testis of the Triturus cristatus carnifex Laur, treated with thiourea].","13768737",193]
["Thiourea","Thiourea","D013890","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,1,1963,"14081714","[INFLUENCE OF THE THYROID GLAND ON THE ENDOCRINE PANCREAS OF RANA ESCULENTA (L.)].","14081714",193]
["Thiourea","Thiourea","D013890","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,1,1964,"14116576","REGULATION OF THYROID FUNCTION IN THE TOAD BUFO BUFO.","14116576",193]
["Thiourea","Thiourea","D013890","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,1,1950,"15432736","Effect of thiouracil on uptake of radioactive iodine by thyroid gland of summer frogs (Rana pipiens).","15432736",193]
["Thiourea","Thiourea","D013890","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,1949,"18113439","The effect of thiourea on the thyroid gland of the winter frog (Rana pipiens) with some observations on the testis.","18113439",193]
["Thiourea","Thiourea","D013890","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,1,1949,"24537051","[The effect of sodium salt of 2-thio-6-methyl-uracil on the course of metamorphosis of the tadpoles of Rana temporaria L].","24537051",193]
["Toluene","Toluene","D014050","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,2008,"18481903","Toxicological responses of red-backed salamanders (Plethodon cinereus) to subchronic soil exposures of 2,4,6-trinitrotoluene.","18481903",193]
["Trenbolone Acetate","Trenbolone Acetate","D014204","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,2013,"22890510","Effects of 17α-trenbolone and melengestrol acetate on Xenopus laevis growth, development, and survival.","22890510",193]
["Trenbolone Acetate","Trenbolone Acetate","D014204","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2012,"22847831","Trenbolone causes mortality and altered sexual differentiation in Xenopus tropicalis during larval development.","22847831",193]
["Trenbolone Acetate","Trenbolone Acetate","D014204","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2015,"25484320","Low concentrations of 17β-trenbolone induce female-to-male reversal and mortality in the frog Pelophylax nigromaculatus.","25484320",193]
["Trenbolone Acetate","Trenbolone Acetate","D014204","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2016,"27143402","Development of the Larval Amphibian Growth and Development Assay: effects of chronic 4-tert-octylphenol or 17β-trenbolone exposure in Xenopus laevis from embryo to juvenile.","27143402",193]
["Trenbolone Acetate","Trenbolone Acetate","D014204","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,2016,"27143402","Development of the Larval Amphibian Growth and Development Assay: effects of chronic 4-tert-octylphenol or 17β-trenbolone exposure in Xenopus laevis from embryo to juvenile.","27143402",193]
["Tretinoin","Tretinoin","D014212","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,2003,"12773776","Comparing the effects of stage and duration of retinoic Acid exposure on amphibian limb development: chronic exposure results in mortality, not limb malformations.","12773776",193]
["Tretinoin","Tretinoin","D014212","1_MIE",1156,1,"Dual oxidase","Inhibition","Dual Oxidases","D000074623","Dual Oxidases",2,2,2010,"20212023","Retinoic acid modulation of thyroid dual oxidase activity in rats and its impact on thyroid iodine organification.","20212023",193]
["Tretinoin","Tretinoin","D014212","1_MIE",1156,1,"Dual oxidase","Inhibition","Dual Oxidases","D000074623","Dual Oxidases",2,2,2010,"20511343","All-trans retinoic acid mediates DUOX2 expression and function in respiratory tract epithelium.","20511343",193]
["Tretinoin","Tretinoin","D014212","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2003,"12773776","Comparing the effects of stage and duration of retinoic Acid exposure on amphibian limb development: chronic exposure results in mortality, not limb malformations.","12773776",193]
["Tretinoin","Tretinoin","D014212","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2004,"15597884","Dietary retinoic acid induces hindlimb and eye deformities in Xenopus laevis.","15597884",193]
["Tretinoin","Tretinoin","D014212","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,2009,"19347951","Evidence for a conserved role of retinoic acid in urodele amphibian meiosis onset.","19347951",193]
["Tretinoin","Tretinoin","D014212","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1986,"3489067","Forelimb regeneration in the postmetamorphic bullfrog: stimulation by dimethyl sulfoxide and retinoic acid.","3489067",193]
["Tretinoin","Tretinoin","D014212","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1998,"9846384","Retinoic acid and thyroid hormone may function through similar and competitive pathways in regenerating axolotls.","9846384",193]
["Tretinoin","Tretinoin","D014212","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,1,2011,"22185339","Retinoic acid is a key regulatory switch determining the difference between lung and thyroid fates in Xenopus laevis.","22185339",193]
["triadimefon","triadimefon","C032910","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2016,"27289584","Waterborne exposure to triadimefon causes thyroid endocrine disruption and developmental delay in Xenopus laevis tadpoles.","27289584",193]
["triadimefon","triadimefon","C032910","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,2016,"27289584","Waterborne exposure to triadimefon causes thyroid endocrine disruption and developmental delay in Xenopus laevis tadpoles.","27289584",193]
["tributyltin","tributyltin","C011559","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2014,"22903176","Effects of tributyltin on metamorphosis and gonadal differentiation of Xenopus laevis at environmentally relevant concentrations.","22903176",193]
["tributyltin","tributyltin","C011559","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2016,"27167774","Trialkyltin Rexinoid-X Receptor Agonists Selectively Potentiate Thyroid Hormone Induced Programs of Xenopus laevis Metamorphosis.","27167774",193]
["tributyltin","tributyltin","C011559","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,2014,"22903176","Effects of tributyltin on metamorphosis and gonadal differentiation of Xenopus laevis at environmentally relevant concentrations.","22903176",193]
["Trichlorfon","Trichlorfon","D014236","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,1985,"3874455","[Effect of thermal selection of the male gametes on the resistance to temperature and chlorophos of the body and muscles in tadpoles of the common frog].","3874455",193]
["triclopyr","triclopyr","C032742","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2017,"28186362","Effects of the herbicide triclopyr on metamorphic northern red-legged frogs.","28186362",193]
["Triclosan","Triclosan","D014260","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,2006,"17011055","The bactericidal agent triclosan modulates thyroid hormone-associated gene expression and disrupts postembryonic anuran development.","17011055",193]
["Triclosan","Triclosan","D014260","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2006,"17011055","The bactericidal agent triclosan modulates thyroid hormone-associated gene expression and disrupts postembryonic anuran development.","17011055",193]
["Triclosan","Triclosan","D014260","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2007,"17265921","Germ fighter works as endocrine disrupter.","17265921",193]
["Triclosan","Triclosan","D014260","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2010,"19917620","Triclosan and anuran metamorphosis: no effect on thyroid-mediated metamorphosis in Xenopus laevis.","19917620",193]
["Triclosan","Triclosan","D014260","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2011,"21071727","Triclosan affects thyroid hormone-dependent metamorphosis in anurans.","21071727",193]
["Triclosan","Triclosan","D014260","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2011,"21436124","Triclosan and thyroid-mediated metamorphosis in anurans: differentiating growth effects from thyroid-driven metamorphosis in Xenopus laevis.","21436124",193]
["Triclosan","Triclosan","D014260","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2011,"21852691","Triclosan affects the thyroid axis of amphibians.","21852691",193]
["Triclosan","Triclosan","D014260","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2013,"23159728","Triclosan exposure alters postembryonic development in a Pacific tree frog (Pseudacris regilla) Amphibian Metamorphosis Assay (TREEMA).","23159728",193]
["Triclosan","Triclosan","D014260","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,2016,"27599820","Chronic effects of triclosan on embryonic development of Chinese toad, Bufo gargarizans.","27599820",193]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C643,B643)","v":"Triclosan"},"Triclosan","D014260","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2017,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q643,Q643)","v":"28436085"},"Effect of triclosan on anuran development and growth in a larval amphibian growth and development assay.","28436085",193]
["Triclosan","Triclosan","D014260","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2018,"29478635","Effects of triclosan on gonadal differentiation and development in the frog Pelophylax nigromaculatus.","29478635",193]
["Triclosan","Triclosan","D014260","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,2010,"19917620","Triclosan and anuran metamorphosis: no effect on thyroid-mediated metamorphosis in Xenopus laevis.","19917620",193]
["Triclosan","Triclosan","D014260","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,2011,"21436124","Triclosan and thyroid-mediated metamorphosis in anurans: differentiating growth effects from thyroid-driven metamorphosis in Xenopus laevis.","21436124",193]
["Triclosan","Triclosan","D014260","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,1,2011,"21852691","Triclosan affects the thyroid axis of amphibians.","21852691",193]
["Triclosan","Triclosan","D014260","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,2017,"28436085","Effect of triclosan on anuran development and growth in a larval amphibian growth and development assay.","28436085",193]
["Trifluoperazine","Trifluoperazine","D014268","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,1993,"7949401","Effect of calcium and calmodulin antagonists on metamorphosis in the anuran tadpole, Rana tigerina.","7949401",193]
["Trinitrotoluene","Trinitrotoluene","D014303","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,2000,"10805152","Effects of 2,4,6-trinitrotoluene in a holistic environmental exposure regime on a terrestrial salamander, Ambystoma tigrinum.","10805152",193]
["Trinitrotoluene","Trinitrotoluene","D014303","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,2008,"18481903","Toxicological responses of red-backed salamanders (Plethodon cinereus) to subchronic soil exposures of 2,4,6-trinitrotoluene.","18481903",193]
["Trinitrotoluene","Trinitrotoluene","D014303","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,2008,"18551238","Acute toxicity of 2,4,6-trinitrotoluene, 2,4-dinitrotoluene, and 2,6-dinitrotoluene in the adult bullfrog (Lithobates catesbeiana).","18551238",193]
["Trinitrotoluene","Trinitrotoluene","D014303","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,2011,"21257201","Effects of chronic 2,4,6,-trinitrotoluene, 2,4-dinitrotoluene, and 2,6-dinitrotoluene exposure on developing bullfrog (Rana catesbeiana) tadpoles.","21257201",193]
["triphenyltin","triphenyltin","C030665","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2006,"16488490","Real-time automated measurement of Xenopus leavis tadpole behavior and behavioral responses following triphenyltin exposure using the multispecies freshwater biomonitor (MFB).","16488490",193]
["triphenyltin","triphenyltin","C030665","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2013,"24177218","Effects of triphenyltin on growth and development of the wood frog (Lithobates sylvaticus).","24177218",193]
["Uracil","Uracil","D014498","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1964,"14209953","PATHWAY OF PYRIMIDINE BIOSYNTHESIS IN PREMETAMORPHIC TADPOLES.","14209953",193]
["Uracil","Uracil","D014498","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1964,"14209954","URACIL METABOLISM IN TADPOLES DURING THYROXINE-INDUCED METAMORPHOSIS.","14209954",193]
["Uracil","Uracil","D014498","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1949,"24537051","[The effect of sodium salt of 2-thio-6-methyl-uracil on the course of metamorphosis of the tadpoles of Rana temporaria L].","24537051",193]
["Uracil","Uracil","D014498","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,1,1949,"24537051","[The effect of sodium salt of 2-thio-6-methyl-uracil on the course of metamorphosis of the tadpoles of Rana temporaria L].","24537051",193]
["Urea","Urea","D014508","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,1999,"10475914","Effects of ammonium nitrate, sodium nitrate, and urea on red-legged frogs, Pacific treefrogs, and African clawed frogs.","10475914",193]
["Urea","Urea","D014508","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,1986,"2874929","Volume regulation in salt-acclimated toad (Bufo viridis): the role of urea and the urinary bladder.","2874929",193]
["Urea","Urea","D014508","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,1998,"9472816","Glyconeogenesis and urea synthesis in the toad Bufo viridis during acclimation to water restriction.","9472816",193]
["Urea","Urea","D014508","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1959,"13672962","Comparative biochemistry of urea synthesis. II. Levels of urea cycle enzymes in metamorphosing Rana catesbeiana tadpoles.","13672962",193]
["Urea","Urea","D014508","6_AO",1101,6,"Amphibian metamorphosis","Altered",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & J664,K664)","v":"Metamorphosis, Biological"},"D008675","Metamorphosis, Biological",2,2,1963,"13958831","Relation of renal tubular transport of urea to its biosynthesis in metamorphosing tadpoles.","13958831",193]
["Urea","Urea","D014508","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1964,"14216408","BIOCHEMICAL METAMORPHOSIS OF HEMOGLOBIN IN RANA CATESBEIANA. I. PURIFICATION PROCEDURES AND PROPERTIES OF HEMOGLOBINS FROM BULLFROG AND TADPOLE ERYTHROCYTES.","14216408",193]
["Urea","Urea","D014508","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1959,"14426063","Changes in the pattern of nitrogen excretion during the life cycle of the newt.","14426063",193]
["Urea","Urea","D014508","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1977,"188719","The hormonal regulation of urea excretion in the Mexican axoloti (Ambystoma mexicanum Cope).","188719",193]
["Urea","Urea","D014508","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,1987,"3500675","Thyroxine elicits divergent changes in mRNA levels for two urea cycle enzymes and one gluconeogenic enzyme in tadpole liver.","3500675",193]
["Urea","Urea","D014508","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,1970,"4193238","Effect of prolactin, growth hormone and ACTH on the urea excretion of bullfrog tadpoles during normal and induced metamorphosis.","4193238",193]
["Urea","Urea","D014508","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,1972,"4537423","A concerted response of the enzymes of urea biosynthesis during thyroxine-induced metamorphosis of Rana catesbeiana.","4537423",193]
["Urea","Urea","D014508","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1970,"5496990","Urea biosynthesis in a surviving amphibian liver cube preparation.","5496990",193]
["Urea","Urea","D014508","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1968,"5642025","Urea excretion in the bullrog tadpole: effect of temperature, metamorphosis, and thyroid hormones.","5642025",193]
["Urea","Urea","D014508","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1967,"6058183","Urea cycle enzymes and  urea excretion during the development and metamorphosis of Xenopus laevis.","6058183",193]
["Urethane","Urethane","D014520","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,1966,"5232396","The protective effects of some narcotic substances against x-irradiation on aquatic animals. (3). Effects of urethane and changes in concentration of chlorobuthanol solution against x-irradiation in larvae of Rhacophorus arboreus.","5232396",193]
["Urethane","Urethane","D014520","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,1967,"5614417","Some pharmacological studies on cryoepilepsy. I. Preliminary report for quantitative studies.","5614417",193]
["Urethane","Urethane","D014520","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1965,"14254996","FURTHER ASPECTS OF LYMPHOSARCOMA IN XENOPUS (THE SOUTH AFRICAN CLAWED TOAD).","14254996",193]
["Vinblastine","Vinblastine","D014747","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1968,"5751113","Amphibian regeneration and the teratogenic effects of vinblastine.","5751113",193]
["Vitamin A","Vitamin A","D014801","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,2010,"20945643","A comparison of oral and topical vitamin A supplementation in African foam-nesting frogs (Chiromantis xerampelina).","20945643",193]
["Vitamin A","Vitamin A","D014801","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,1974,"4544648","Incorporation of (3H)vitamin A into rhodopsin in light- and dark-adapted frogs.","4544648",193]
["Vitamin A","Vitamin A","D014801","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1975,"1210015","Storage, distribution and utilization of vitamins A in the eyes of adult amphibians and their tadpoles.","1210015",193]
["Vitamin A","Vitamin A","D014801","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1964,"14217777","METABOLIC BASIS OF VISUAL PIGMENT CONVERSION IN METAMORPHOSING RANA CATESBEIANA.","14217777",193]
["Vitamin A","Vitamin A","D014801","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1965,"14267998","EFFECTS OF HYPERVITAMINOSIS A ON TADPOLE METAMORPHOSIS.","14267998",193]
["Vitamin A","Vitamin A","D014801","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1988,"3401522","Vitamin A induced bilateral asymmetries in triturus forelimb regenerates.","3401522",193]
["Vitamin A","Vitamin A","D014801","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,1980,"7465810","The effects of dexamethasone (DXM) and vitamin A on the growth and metamorphosis of gamma irradiated thyroxine induced Bufo melanostictus tadpoles.","7465810",193]
["Vitamin A","Vitamin A","D014801","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,1972,"5049293","The influence of excess vitamin A on the growth of frog tadpoles with particular reference to thyroid glands.","5049293",193]
["Vitamin B 12","Vitamin B 12","D014805","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1954,"13181077","Effect of aureomycin, B12, folic acid and aminopterin on the metamorphosis of tadpoles.","13181077",193]
["Vitamin B 12","Vitamin B 12","D014805","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1960,"13703010","[Effect of certain antibiotics and of vitamin B-12 on growth and on metamorphosis of tadpoles of Bufo vulgaris].","13703010",193]
["Vitamin B 12","Vitamin B 12","D014805","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1960,"13703011","[Effects of some antibiotics and vitamin B12 on the growth and metamorphosis of tadpoles of Bufo vulgaris].","13703011",193]
["Vitamin D","Vitamin D","D014807","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1962,"14453011","Effect of water-miscible preparation of vitamin D2 on metamorphosis of thiourea and citrate treated Rana pipiens larvae.","14453011",193]
["Vitamin E","Vitamin E","D014810","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1958,"13639470","[Vitamin E stimulates larval growth and hastens metamorphosis in the toad, Alytes obstetricans Laur].","13639470",193]
["Waste Water","Waste Water","D062065","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2018,"28648371","Impacts of tannery effluent on development and morphological characters in a neotropical tadpole.","28648371",193]
["Waste Water","Waste Water","D062065","2_KE",277,2,"Thyroid hormone synthesis","Decreased","Thyroid Gland","D013961","Thyroid Gland",1,2,2013,"23823564","In vivo endocrine disruption assessment of wastewater treatment plant effluents with small organisms.","23823564",193]
["Water","Water","D014867","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,1999,"10404645","Elevated plasma osmotic concentration stimulates water absorption response in a toad.","10404645",193]
["Water","Water","D014867","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,1964,"14266693","THE EFFECT OF TEMPERATURE ON WEIGHT CHANGES AND WATER FLUXES IN THE COMMON FROG RANA TEMPORARIA.","14266693",193]
["Water","Water","D014867","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,1965,"14326049","PHYLOGENETIC DISTRIBUTION OF THE EFFECTS OF NEUROHYPOPHYSIAL HORMONES ON WATER AND SODIUM METABOLISM.","14326049",193]
["Water","Water","D014867","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,2013,"23344427","Food availability determines the response to pond desiccation in anuran tadpoles.","23344427",193]
["Water","Water","D014867","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,2016,"27318278","Interactions between a small chronic increase in diel water temperature and exposure to a common environmental contaminant on development of Arizona tiger salamander larvae.","27318278",193]
["Water","Water","D014867","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,2017,"28384420","Not Good, but Not All Bad: Dehydration Effects on Body Fluids, Organ Masses, and Water Flux through the Skin of Rhinella schneideri (Amphibia, Bufonidae).","28384420",193]
["Water","Water","D014867","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,1987,"3305152","Water uptake by Rana temporaria: effects of diuretics and the renin--angiotensin system, and nephrectomy.","3305152",193]
["Water","Water","D014867","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,1971,"4257741","[Participation of the antidiuretic hormone (ADH) in the activity of chlorpropamide on water metabolism, in toads].","4257741",193]
["Water","Water","D014867","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,1972,"4335780","Hormonal regulation of the skin diffusional permeability to water during development and metamorphosis of Xenopus laevis Daudin.","4335780",193]
["Water","Water","D014867","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,1972,"4543863","Influence of trace elements on the water balance of the blood of amphibians in a system of dehydration at various seasons of the year.","4543863",193]
["Water","Water","D014867","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,2,1968,"5721743","Increased water uptake and retention in amphibian by carbon tetrachloride.","5721743",193]
["Water","Water","D014867","6_AO",1101,6,"Amphibian metamorphosis","Altered","Body Weight","D001835","Body Weight",1,1,1997,"9185343","Salt and water balance in the toad Bufo viridis during recovery from two different osmotically stressful conditions.","9185343",193]
["Water","Water","D014867","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1975,"1085932","[Influence of the environment on the metamorphosis of amphibians (temperature, light, molecular concentration of water)].","1085932",193]
["Water","Water","D014867","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1955,"13239825","[Factors of growth and metamorphosis of amphibian larvae. VI. Effect of a water-soluble derivative of p-hydroxypropiophenone].","13239825",193]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/record/ui?ui=\" & C707,B707)","v":"Water"},"Water","D014867","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1958,{"$f":"HYPERLINK(\"https://www.ncbi.nlm.nih.gov/pubmed/\" & Q707,Q707)","v":"13576433"},"[Effect of pitressin &amp; adrenalin on water balance in the toad during &amp; after metamorphosis].","13576433",193]
["Water","Water","D014867","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1962,"14453011","Effect of water-miscible preparation of vitamin D2 on metamorphosis of thiourea and citrate treated Rana pipiens larvae.","14453011",193]
["Water","Water","D014867","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2009,"19663642","Effects of salinity on the survival, growth, development, and metamorphosis of Fejervarya limnocharis tadpoles living in brackish water.","19663642",193]
["Water","Water","D014867","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,2012,"22488805","Effects of leachate from tree leaves and grass litter on tadpoles.","22488805",193]
["Water","Water","D014867","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,2013,"23344427","Food availability determines the response to pond desiccation in anuran tadpoles.","23344427",193]
["Water","Water","D014867","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,2014,"24668655","Effects of hydroperiod duration on developmental plasticity in tiger frog (Hoplobatrachus chinensis) tadpoles.","24668655",193]
["Water","Water","D014867","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2016,"27318278","Interactions between a small chronic increase in diel water temperature and exposure to a common environmental contaminant on development of Arizona tiger salamander larvae.","27318278",193]
["Water","Water","D014867","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,2016,"27714986","Effects of Water Loss on New Mexico Spadefoot Toad (Spea multiplicata) Development, Spleen Cellularity, and Corticosterone Levels.","27714986",193]
["Water","Water","D014867","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,2017,"27990576","Coordinated shift of olfactory amino acid responses and V2R expression to an amphibian water nose during metamorphosis.","27990576",193]
["Water","Water","D014867","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1972,"4335780","Hormonal regulation of the skin diffusional permeability to water during development and metamorphosis of Xenopus laevis Daudin.","4335780",193]
["Water","Water","D014867","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1970,"5438610","Neurohypophysial function in bullfrog (Rana catesbeiana) tadpoles.","5438610",193]
["Water","Water","D014867","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,2,1970,"5462683","[Influence of aldosterone on sodium transport and transepithelial water flux through isolated ventral skin of Rana temporaria].","5462683",193]
["Zinc Oxide","Zinc Oxide","D015034","6_AO",1101,6,"Amphibian metamorphosis","Altered","Metamorphosis, Biological","D008675","Metamorphosis, Biological",2,4,2011,"20801509","Effects of ZnO nanomaterials on Xenopus laevis growth and development.","20801509",193]