{"text_format":"1","workbook":"xlsx","n_sheets":3,"sheets":["ReadMe","Overview","Detail"],"not_rendered":{"charts":0,"images":0,"macros":1,"external_links":0,"defined_names":3,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900"}

{"sheet":"ReadMe","index":0,"n_rows":1,"n_cols":1,"rows_kept":1,"cut":false,"hidden":false,"merged":[]}
["Read Me"]

{"sheet":"Overview","index":1,"n_rows":608,"n_cols":32,"rows_kept":608,"cut":false,"hidden":false,"merged":[]}
["Overview"]
["How to use:  search, sort and double-click on article counts.","Article Counts"]
["Chemical","Aldehyde Oxidoreductases_antag","CYP1A1 protein, human_antag","Cytochrome P-450 CYP1A1_antag","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid_antag","Retinal Dehydrogenase_antag","retinoic acid 4-hydroxylase_antag","retinoic acid binding protein I, cellular_ag","retinoic acid binding protein I, cellular_antag","retinoic acid binding protein II, cellular_ag","retinoic acid binding protein II, cellular_antag","retinoic acid receptor alpha_ag","retinoic acid receptor alpha_antag","retinoic acid receptor beta_ag","retinoic acid receptor beta_antag","retinoic acid receptor gamma_ag","retinoic acid receptor gamma_antag","retinoic acid receptor, beta2, human_ag","retinoic acid receptor, beta2, human_antag","Retinoid X Receptor alpha_ag","Retinoid X Receptor alpha_antag","Retinoid X Receptor beta_ag","Retinoid X Receptor beta_antag","Retinoid X Receptor gamma_ag","Retinoid X Receptor gamma_antag","Retinoid X Receptors_ag","Retinoid X Receptors_antag","Retinol-Binding Proteins, Plasma_ag","Retinol-Binding Proteins, Plasma_antag","Retinol-Binding Proteins_antag","ChemName"]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  AF4,AF4)","v":"Tretinoin"},3,0,1,83,85,4,10,1,1,5,1,27,30,4,12,6,6,0,1,3,4,0,0,0,0,52,16,0,0,1,"Tretinoin"]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  AF5,AF5)","v":"alitretinoin"},1,0,0,15,8,1,0,0,0,0,0,2,1,0,1,0,0,0,0,1,1,0,0,0,0,23,4,0,0,0,"alitretinoin"]
["4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid",0,0,0,6,7,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,4,4,0,0,0,"4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid"]
["AGN 193109",0,0,0,1,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"AGN 193109"]
["Ro 41-5253",0,0,0,1,6,0,0,0,0,0,1,1,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Ro 41-5253"]
["Fenretinide",0,0,0,0,6,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,1,0,"Fenretinide"]
["Isotretinoin",0,0,0,3,4,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,1,1,0,0,0,"Isotretinoin"]
["BMS 189453",0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"BMS 189453"]
["LE 135",0,0,0,0,4,0,0,0,0,0,0,0,0,0,2,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,"LE 135"]
["Vitamin A",0,0,2,4,3,0,2,0,0,1,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,2,0,0,0,0,"Vitamin A"]
["bexarotene",0,0,0,11,3,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,1,0,0,0,0,43,4,0,0,0,"bexarotene"]
["Am 580",0,0,0,11,3,0,0,0,0,0,0,9,1,1,0,2,0,0,0,0,0,0,0,0,0,3,0,0,0,0,"Am 580"]
["CD 437",0,0,0,6,3,0,0,0,0,0,0,2,0,0,0,5,0,0,0,0,0,0,0,0,0,2,0,0,0,0,"CD 437"]
["4-((4-(4-ethylphenyl)-2,2-dimethyl-(2H)-thiochromen-6-yl)ethynyl)benzoic acid",0,0,0,0,3,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,"4-((4-(4-ethylphenyl)-2,2-dimethyl-(2H)-thiochromen-6-yl)ethynyl)benzoic acid"]
["beta-apo-13-carotenone",0,0,0,0,2,0,0,0,0,0,0,0,0,0,1,0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,"beta-apo-13-carotenone"]
["rosiglitazone",0,0,0,12,2,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,13,3,0,0,0,"rosiglitazone"]
["LG 100268",0,0,0,8,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,11,2,0,0,0,"LG 100268"]
["AGN 190121",0,0,0,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,"AGN 190121"]
["4-(4,5,7,8,9,10-hexahydro-7,7,10,10-tetramethyl-1-(3-pyridylmethyl)anthra-(1,2-b)pyrrol-3-yl)benzoic acid",0,0,0,1,2,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,"4-(4,5,7,8,9,10-hexahydro-7,7,10,10-tetramethyl-1-(3-pyridylmethyl)anthra-(1,2-b)pyrrol-3-yl)benzoic acid"]
["BMS453",0,0,0,1,2,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,"BMS453"]
["Morphine",0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,1,0,0,0,"Morphine"]
["3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid",0,0,0,0,2,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,"3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid"]
["beta-apo-14'-carotenal",0,0,0,0,2,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"beta-apo-14'-carotenal"]
["Calcitriol",0,0,0,2,1,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,1,1,0,0,0,1,1,0,0,0,"Calcitriol"]
["resveratrol",0,1,13,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"resveratrol"]
["Genistein",0,0,3,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Genistein"]
["Melatonin",0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Melatonin"]
["tributyltin",0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,3,0,0,0,0,"tributyltin"]
["Fluoxetine",0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Fluoxetine"]
["Hydrogen Peroxide",0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,"Hydrogen Peroxide"]
["RNA, Small Interfering",0,0,1,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"RNA, Small Interfering"]
["4-(2-(5,6-dihydro-5,5-dimethyl-8-(2-phenylethynyl)naphthalen-2-yl)ethen-1-yl)benzoic acid",0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,"4-(2-(5,6-dihydro-5,5-dimethyl-8-(2-phenylethynyl)naphthalen-2-yl)ethen-1-yl)benzoic acid"]
["4-(5,6-dihydro-5,5-dimethyl-8-(quinolin-3-yl)naphthalen-2-carboxamido)benzoic acid",0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,"4-(5,6-dihydro-5,5-dimethyl-8-(quinolin-3-yl)naphthalen-2-carboxamido)benzoic acid"]
["Acitretin",0,0,0,2,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Acitretin"]
["Cholesterol",0,0,0,2,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Cholesterol"]
["LG 100754",0,0,0,2,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,1,0,0,0,"LG 100754"]
["octa-2,4,6-trienoic acid",0,0,0,2,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"octa-2,4,6-trienoic acid"]
["Prostaglandin D2",0,0,0,2,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,"Prostaglandin D2"]
["15-deoxy-delta(12,14)-prostaglandin J2",0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,"15-deoxy-delta(12,14)-prostaglandin J2"]
["4-oxoretinoic acid",0,0,0,1,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"4-oxoretinoic acid"]
["7-(1-(1-methylethyl)-8-chloro-1,2,3,4-tetrahydroquinolin-6-yl)-6-fluoro-3-methyl-2,4,6-nonatrienoic acid",0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,"7-(1-(1-methylethyl)-8-chloro-1,2,3,4-tetrahydroquinolin-6-yl)-6-fluoro-3-methyl-2,4,6-nonatrienoic acid"]
["9,13-retinoic acid",0,0,0,1,1,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"9,13-retinoic acid"]
["AGN 191659",0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,"AGN 191659"]
["AGN 193836",0,0,0,1,1,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,"AGN 193836"]
["beta Carotene",0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"beta Carotene"]
["Cholecalciferol",0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,"Cholecalciferol"]
["Dinoprostone",0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Dinoprostone"]
["Diphenylamine",0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,"Diphenylamine"]
["Leukotriene B4",0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Leukotriene B4"]
["pioglitazone",0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,"pioglitazone"]
["tazarotene",0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,"tazarotene"]
["1-isopropyloxygenipin",0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"1-isopropyloxygenipin"]
["1-phenylcyclohex-1-ene",0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"1-phenylcyclohex-1-ene"]
["24,25-epoxycholesterol",0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"24,25-epoxycholesterol"]
["2-fluoro-4-(((8-bromo-2,2-dimethyl-4-(4-methylphenyl)chroman-6-yl)carbonyl)amino)benzoic acid",0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"2-fluoro-4-(((8-bromo-2,2-dimethyl-4-(4-methylphenyl)chroman-6-yl)carbonyl)amino)benzoic acid"]
["3-methyladenine",0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"3-methyladenine"]
["4-hydroxyretinoic acid",0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"4-hydroxyretinoic acid"]
["5,6-epoxyretinoic acid",0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"5,6-epoxyretinoic acid"]
["7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide",0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"]
["Adamantane",0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,"Adamantane"]
["Adenine",0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Adenine"]
["andrographolide",0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"andrographolide"]
["apo-14'-carotenoic acid",0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"apo-14'-carotenoic acid"]
["benzochromenyl retinoid",0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"benzochromenyl retinoid"]
["benzothiochromenyl retinoid",0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"benzothiochromenyl retinoid"]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  AF69,AF69)","v":"bepafant"},0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"bepafant"]
["BW 373U86",0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"BW 373U86"]
["CD2665",0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"CD2665"]
["Chlorambucil",0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Chlorambucil"]
["Chloroquine",0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Chloroquine"]
["Cytarabine",0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Cytarabine"]
["diazepinylbenzoic acid",0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,5,0,0,0,"diazepinylbenzoic acid"]
["dihydroanthracenyl retinoid",0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"dihydroanthracenyl retinoid"]
["Ethanol",16,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,"Ethanol"]
["genipin",0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"genipin"]
["Griseofulvin",0,0,0,0,1,0,0,0,0,0,0,0,1,0,1,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,"Griseofulvin"]
["GSK 461364",0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"GSK 461364"]
["LE 540",0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"LE 540"]
["Materia Medica",0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Materia Medica"]
["Retinaldehyde",0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Retinaldehyde"]
["Sirolimus",0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Sirolimus"]
["SR 11234",0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"SR 11234"]
["triphenyl phosphate",0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"triphenyl phosphate"]
["triphenyltin",0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,3,0,0,0,0,"triphenyltin"]
["WEB 2086",0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"WEB 2086"]
["4-oxoretinol",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"4-oxoretinol"]
["anhydrovitamin A",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"anhydrovitamin A"]
["beta-ionone",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"beta-ionone"]
["UAB 30",0,0,0,2,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,2,0,0,0,0,0,3,0,0,0,0,"UAB 30"]
["magnolol",0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,"magnolol"]
["Propane",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,"Propane"]
["calcipotriene",0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,0,1,0,0,0,0,0,0,0,0,"calcipotriene"]
["(E)-1-(2-nitrovinyl)naphthalene",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,"(E)-1-(2-nitrovinyl)naphthalene"]
["(E)-9-(2-nitrovinyl)anthracene",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,"(E)-9-(2-nitrovinyl)anthracene"]
["liarozole",0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"liarozole"]
["R 115866",0,0,0,1,0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"R 115866"]
["R116010",0,0,0,0,0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"R116010"]
["4'-octyl-4-biphenylcarboxylic acid",0,0,0,2,0,0,1,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"4'-octyl-4-biphenylcarboxylic acid"]
["2,2-dimethyl-3-(4-(naphthalen-2-ylamino)phenyl)-3-(1,2,4)triazol-1-yl-propionic acid methyl ester",0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"2,2-dimethyl-3-(4-(naphthalen-2-ylamino)phenyl)-3-(1,2,4)triazol-1-yl-propionic acid methyl ester"]
["2-Naphthylamine",0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,"2-Naphthylamine"]
["3-(6-(2-dimethylamino-1-imidazol-1-yl-butyl)naphthalen-2-yloxy)-2,2-dimethyl-propionic acid",0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"3-(6-(2-dimethylamino-1-imidazol-1-yl-butyl)naphthalen-2-yloxy)-2,2-dimethyl-propionic acid"]
["methyl 3-(4-(6-bromopyridin-3-ylamino)phenyl)-3-(1H-imidazol-1-yl)-2,2-dimethylpropanoate",0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"methyl 3-(4-(6-bromopyridin-3-ylamino)phenyl)-3-(1H-imidazol-1-yl)-2,2-dimethylpropanoate"]
["Nicotine",0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Nicotine"]
["Benzo(a)pyrene",0,0,23,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Benzo(a)pyrene"]
["Tetrachlorodibenzodioxin",1,0,21,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Tetrachlorodibenzodioxin"]
["beta-Naphthoflavone",0,1,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"beta-Naphthoflavone"]
["alpha-naphthoflavone",0,0,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"alpha-naphthoflavone"]
["Omeprazole",0,1,5,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Omeprazole"]
["9,10-Dimethyl-1,2-benzanthracene",0,0,5,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"9,10-Dimethyl-1,2-benzanthracene"]
["alpha-methylbenzylaminobenzotriazole",0,0,5,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"alpha-methylbenzylaminobenzotriazole"]
["Estradiol",0,0,5,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Estradiol"]
["Quercetin",0,0,4,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Quercetin"]
["3,4,5,3',4'-pentachlorobiphenyl",0,1,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"3,4,5,3',4'-pentachlorobiphenyl"]
["chrysin",0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"chrysin"]
["Curcumin",0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Curcumin"]
["Ketoconazole",0,0,3,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,"Ketoconazole"]
["1-aminobenzotriazole",0,0,3,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"1-aminobenzotriazole"]
["Acetylene",0,0,3,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Acetylene"]
["Aflatoxin B1",0,0,3,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Aflatoxin B1"]
["Clotrimazole",0,0,3,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Clotrimazole"]
["furafylline",0,0,3,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"furafylline"]
["indole-3-carbinol",0,0,3,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"indole-3-carbinol"]
["N-benzyl-1-aminobenzotriazole",0,0,3,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"N-benzyl-1-aminobenzotriazole"]
["rutecarpine",0,0,3,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"rutecarpine"]
["Theophylline",0,0,3,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Theophylline"]
["arsenite",4,0,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,"arsenite"]
["Berberine",0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Berberine"]
["Cannabidiol",0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Cannabidiol"]
["Dexamethasone",0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Dexamethasone"]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  AF133,AF133)","v":"Metformin"},0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Metformin"]
["1-ethynylpyrene",0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"1-ethynylpyrene"]
["2-anthramine",0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"2-anthramine"]
["3,3'-diindolylmethane",0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"3,3'-diindolylmethane"]
["Ascorbic Acid",0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Ascorbic Acid"]
["benzo(a)pyrene 7,8-dihydrodiol",0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"benzo(a)pyrene 7,8-dihydrodiol"]
["biochanin A",0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"biochanin A"]
["Cadmium",0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Cadmium"]
["Chalcone",0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Chalcone"]
["Cimetidine",0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Cimetidine"]
["daidzein",0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"daidzein"]
["Dehydroepiandrosterone",0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Dehydroepiandrosterone"]
["Fluvoxamine",0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Fluvoxamine"]
["galangin",0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"galangin"]
["indolo(3,2-b)carbazole",0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"indolo(3,2-b)carbazole"]
["Methylcholanthrene",0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Methylcholanthrene"]
["Mexiletine",0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Mexiletine"]
["Safrole",0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Safrole"]
["sanguinarine",0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"sanguinarine"]
["sodium arsenite",0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"sodium arsenite"]
["Tacrine",0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Tacrine"]
["Toluene",0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Toluene"]
["Sulindac",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,3,0,0,0,0,0,0,0,0,0,"Sulindac"]
["aristolochic acid I",0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"aristolochic acid I"]
["Carbamazepine",0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Carbamazepine"]
["DDT",0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"DDT"]
["Dichlorodiphenyl Dichloroethylene",0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Dichlorodiphenyl Dichloroethylene"]
["jatrorrhizine",0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"jatrorrhizine"]
["luotonin A",0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"luotonin A"]
["palmatine",0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"palmatine"]
["1,2,4-triazine",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"1,2,4-triazine"]
["1,2,4-trihydroxy-9,10-anthracenedione",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"1,2,4-trihydroxy-9,10-anthracenedione"]
["1,3-benzodioxole",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"1,3-benzodioxole"]
["1,4-phenylenebis(methylene)selenocyanate",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"1,4-phenylenebis(methylene)selenocyanate"]
["1-furan-2-yl-3-pyridin-2-yl-propenone",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"1-furan-2-yl-3-pyridin-2-yl-propenone"]
["1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"]
["1-methyl-4-phenyl-2,3-dihydropyridinium",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"1-methyl-4-phenyl-2,3-dihydropyridinium"]
["1-Methyl-4-phenylpyridinium",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"1-Methyl-4-phenylpyridinium"]
["1-nitropyrene",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"1-nitropyrene"]
["2-((2,6-dichlorophenyl)amino)benzeneacetic acid 4-(3H-1,2-dithiol-3-thione-5-yl)phenyl ester",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"2-((2,6-dichlorophenyl)amino)benzeneacetic acid 4-(3H-1,2-dithiol-3-thione-5-yl)phenyl ester"]
["2,2',4,6,6'-pentachlorobiphenyl",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"2,2',4,6,6'-pentachlorobiphenyl"]
["2,2',4,6'-tetramethoxystilbene",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"2,2',4,6'-tetramethoxystilbene"]
["2,3,7,8-tetrabromodibenzo-4-dioxin",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"2,3,7,8-tetrabromodibenzo-4-dioxin"]
["2,4,5,2',4',5'-hexachlorobiphenyl",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"2,4,5,2',4',5'-hexachlorobiphenyl"]
["2,5,2',5'-tetrachlorobiphenyl",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"2,5,2',5'-tetrachlorobiphenyl"]
["2-Acetylaminofluorene",1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"2-Acetylaminofluorene"]
["2-amino-3,4-dimethylimidazo(4,5-f)quinoline",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"2-amino-3,4-dimethylimidazo(4,5-f)quinoline"]
["2-butenal",1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"2-butenal"]
["2-chloroethyl ethyl sulfide",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"2-chloroethyl ethyl sulfide"]
["2-ethynylnaphthalene",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"2-ethynylnaphthalene"]
["2-hydroxy-3-methoxyestradiol",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"2-hydroxy-3-methoxyestradiol"]
["2-methoxyestradiol",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"2-methoxyestradiol"]
["2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide"]
["2-oxohexyl isothiocyanate",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"2-oxohexyl isothiocyanate"]
["2-phenylphenanthridinone",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"2-phenylphenanthridinone"]
["2-toluidine",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"2-toluidine"]
["3-(2-(2,4,6-trimethylphenyl)thioethyl)-4-methylsydnone",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"3-(2-(2,4,6-trimethylphenyl)thioethyl)-4-methylsydnone"]
["3-(2-ethylphenyl)-5-(3-methoxyphenyl)-1H,2,4-triazol",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"3-(2-ethylphenyl)-5-(3-methoxyphenyl)-1H,2,4-triazol"]
["3-(alpha,alpha-dimethylallyl)psoralen",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"3-(alpha,alpha-dimethylallyl)psoralen"]
["3,3',4,5'-tetrahydroxystilbene",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"3,3',4,5'-tetrahydroxystilbene"]
["3,4,3',4'-tetrachlorobiphenyl",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"3,4,3',4'-tetrachlorobiphenyl"]
["3',4'-dimethoxyflavone",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"3',4'-dimethoxyflavone"]
["3,5-dicarbethoxy-2,6-dimethyl-4-ethyl-1,4-dihydropyridine",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"3,5-dicarbethoxy-2,6-dimethyl-4-ethyl-1,4-dihydropyridine"]
["3,5-dihydroxy-4'-methoxystilbene",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"3,5-dihydroxy-4'-methoxystilbene"]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  AF197,AF197)","v":"3-methoxy-4'-methylthiostilbene"},0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"3-methoxy-4'-methylthiostilbene"]
["3'-methoxy-4'-nitroflavone",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"3'-methoxy-4'-nitroflavone"]
["4-methoxyestradiol",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"4-methoxyestradiol"]
["4-nonylphenol",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"4-nonylphenol"]
["5,7-dimethoxyflavone",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"5,7-dimethoxyflavone"]
["5-androstene-16-fluoro-17-one",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"5-androstene-16-fluoro-17-one"]
["6,12-diformylindolo(3,2-b)carbazole",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"6,12-diformylindolo(3,2-b)carbazole"]
["6-formylindolo(3,2-b)carbazole",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"6-formylindolo(3,2-b)carbazole"]
["6-methyl-1,3,8-trichlorodibenzofuran",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"6-methyl-1,3,8-trichlorodibenzofuran"]
["7,12-dimethylbenz(a)anthracene-dihydrodiol",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"7,12-dimethylbenz(a)anthracene-dihydrodiol"]
["7,12-dimethylbenz(a)anthracene-DNA adduct",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"7,12-dimethylbenz(a)anthracene-DNA adduct"]
["7-ethynylcoumarin",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"7-ethynylcoumarin"]
["8-prenylnaringenin",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"8-prenylnaringenin"]
["9-hydroxybenzo(a)pyrene",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"9-hydroxybenzo(a)pyrene"]
["Acrolein",1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Acrolein"]
["Acrylamide",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Acrylamide"]
["aflatoxin B1-8,9-dihydrodiol-Tris buffer complex",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"aflatoxin B1-8,9-dihydrodiol-Tris buffer complex"]
["alantolactone",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"alantolactone"]
["Albendazole",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Albendazole"]
["alizarin",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"alizarin"]
["allyl isothiocyanate",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"allyl isothiocyanate"]
["allyl sulfide",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"allyl sulfide"]
["alpha-terpineol",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"alpha-terpineol"]
["alyssin",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"alyssin"]
["Amiloride",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Amiloride"]
["Amiodarone",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Amiodarone"]
["anthra(1,9-cd)pyrazol-6(2H)-one",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"anthra(1,9-cd)pyrazol-6(2H)-one"]
["Apigenin",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Apigenin"]
["Arecoline",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Arecoline"]
["Arsenic",1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Arsenic"]
["Atracurium",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Atracurium"]
["avarol",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"avarol"]
["avarone",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"avarone"]
["avasimibe",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"avasimibe"]
["benzo(a)pyrene-DNA adduct",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"benzo(a)pyrene-DNA adduct"]
["benzo(d)thiazol-2-amine",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"benzo(d)thiazol-2-amine"]
["benzothiazole",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"benzothiazole"]
["benzyl selenocyanate",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"benzyl selenocyanate"]
["bergamottin",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"bergamottin"]
["bisabolol",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"bisabolol"]
["bisphenol A",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"bisphenol A"]
["boldine",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"boldine"]
["Bortezomib",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Bortezomib"]
["butenylisothiocyanate",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"butenylisothiocyanate"]
["Butylated Hydroxytoluene",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Butylated Hydroxytoluene"]
["cafestol",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"cafestol"]
["Caffeine",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Caffeine"]
["Capsaicin",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Capsaicin"]
["Carbon Tetrachloride",3,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Carbon Tetrachloride"]
["Carmine",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Carmine"]
["Catechin",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Catechin"]
["chelerythrine",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"chelerythrine"]
["chlorophyllin",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"chlorophyllin"]
["Chlorpromazine",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Chlorpromazine"]
["chrysoeriol",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"chrysoeriol"]
["Ciprofloxacin",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Ciprofloxacin"]
["cirsiliol",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"cirsiliol"]
["Clofibric Acid",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Clofibric Acid"]
["Clozapine",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Clozapine"]
["Copper Sulfate",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Copper Sulfate"]
["coriandrin",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"coriandrin"]
["coumarin",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"coumarin"]
["Creosote",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Creosote"]
["daidzin",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"daidzin"]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  AF261,AF261)","v":"dehydroevodiamine"},0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"dehydroevodiamine"]
["dehydrosilybin",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"dehydrosilybin"]
["desethylamiodarone",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"desethylamiodarone"]
["dibenzo(a,l)pyrene",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"dibenzo(a,l)pyrene"]
["dibutylnitrosamine",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"dibutylnitrosamine"]
["Dicarbethoxydihydrocollidine",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Dicarbethoxydihydrocollidine"]
["Diclofenac",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Diclofenac"]
["difloxacin",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"difloxacin"]
["Diflubenzuron",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Diflubenzuron"]
["dihydronarciclasine",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"dihydronarciclasine"]
["dihydrosafrole",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"dihydrosafrole"]
["diindolylmethane",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"diindolylmethane"]
["DNA-(2-amino-3-methylimidazo(4,5-f)quinoline) adduct",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"DNA-(2-amino-3-methylimidazo(4,5-f)quinoline) adduct"]
["Ellagic Acid",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Ellagic Acid"]
["Endosulfan",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Endosulfan"]
["enrofloxacin",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"enrofloxacin"]
["epigallocatechin gallate",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"epigallocatechin gallate"]
["erucin",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"erucin"]
["erysolin",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"erysolin"]
["Erythromycin",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Erythromycin"]
["Estriol",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Estriol"]
["Ethinyl Estradiol",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Ethinyl Estradiol"]
["ethylbenzene",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"ethylbenzene"]
["ethylisopropylamiloride",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"ethylisopropylamiloride"]
["eucalyptol",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"eucalyptol"]
["evodiamine",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"evodiamine"]
["Famotidine",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Famotidine"]
["flavanone",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"flavanone"]
["Fluconazole",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Fluconazole"]
["fluoranthene",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"fluoranthene"]
["formononetin",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"formononetin"]
["genistin",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"genistin"]
["helenalin",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"helenalin"]
["imperatorin",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"imperatorin"]
["isopimpinellin",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"isopimpinellin"]
["isoquercitrin",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"isoquercitrin"]
["isosafrole",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"isosafrole"]
["Itraconazole",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Itraconazole"]
["IY 80843",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"IY 80843"]
["IY 80845",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"IY 80845"]
["kahweol",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"kahweol"]
["lead acetate",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"lead acetate"]
["levan",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"levan"]
["Lidocaine",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Lidocaine"]
["lycopene",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"lycopene"]
["malassezin",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"malassezin"]
["Mangifera indica extract",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Mangifera indica extract"]
["meso-zeaxanthin",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"meso-zeaxanthin"]
["Methoxychlor",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Methoxychlor"]
["methylmercuric chloride",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"methylmercuric chloride"]
["Miconazole",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Miconazole"]
["molybdate",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"molybdate"]
["Molybdenum",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Molybdenum"]
["muconaldehyde",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"muconaldehyde"]
["N-(2-heptyl)-propargylamine",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"N-(2-heptyl)-propargylamine"]
["NADP",1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"NADP"]
["narciclasine",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"narciclasine"]
["naringenin",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"naringenin"]
["neoquassin",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"neoquassin"]
["Niclosamide",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Niclosamide"]
["Nitric Oxide",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,"Nitric Oxide"]
["N-nitrosopiperidine",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"N-nitrosopiperidine"]
["Nocodazole",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Nocodazole"]
["noduliprevenone",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"noduliprevenone"]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  AF325,AF325)","v":"nonylphenol"},0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"nonylphenol"]
["NSC 674495",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"NSC 674495"]
["oltipraz",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"oltipraz"]
["oxatomide",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"oxatomide"]
["Pargyline",5,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Pargyline"]
["Particulate Matter",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Particulate Matter"]
["Pentachlorophenol",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Pentachlorophenol"]
["phenethyl isothiocyanate",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"phenethyl isothiocyanate"]
["Phenobarbital",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Phenobarbital"]
["phentin acetate",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"phentin acetate"]
["phenylacetylene",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"phenylacetylene"]
["Pilocarpine",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Pilocarpine"]
["pinostilbene",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"pinostilbene"]
["prochloraz",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"prochloraz"]
["Progesterone",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Progesterone"]
["Promazine",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Promazine"]
["propargyl ether",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"propargyl ether"]
["protocatechuic acid",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"protocatechuic acid"]
["pterostilbene",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"pterostilbene"]
["punicalagin",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"punicalagin"]
["punicalin",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"punicalin"]
["quassin",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"quassin"]
["Quinidine",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Quinidine"]
["retene",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"retene"]
["retinol palmitate",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"retinol palmitate"]
["rhapontigenin",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"rhapontigenin"]
["Roxithromycin",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Roxithromycin"]
["Salvia extract",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Salvia extract"]
["SB 203580",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"SB 203580"]
["sesamin",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"sesamin"]
["sesamodil",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"sesamodil"]
["silybin",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"silybin"]
["Silymarin",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Silymarin"]
["Smoke",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Smoke"]
["sodium arsenate",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"sodium arsenate"]
["Sodium Selenite",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Sodium Selenite"]
["SRM 1597",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"SRM 1597"]
["S-sulindac",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"S-sulindac"]
["tangeretin",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"tangeretin"]
["tanshinone",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"tanshinone"]
["tebufelone",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"tebufelone"]
["Tellurium",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Tellurium"]
["TEMPO",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"TEMPO"]
["Testosterone",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Testosterone"]
["Tetradecanoylphorbol Acetate",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,"Tetradecanoylphorbol Acetate"]
["Thioridazine",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Thioridazine"]
["Tocainide",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Tocainide"]
["trichostatin A",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"trichostatin A"]
["Triclosan",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Triclosan"]
["trimethyltin",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"trimethyltin"]
["Troleandomycin",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Troleandomycin"]
["tryolobibenzyl D",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"tryolobibenzyl D"]
["Vitamin K",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Vitamin K"]
["xanthohumol",0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"xanthohumol"]
["13,14-dihydroretinoic acid",0,0,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"13,14-dihydroretinoic acid"]
["retinyl retinoate",0,0,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"retinyl retinoate"]
["citral",1,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"citral"]
["Clofibrate",1,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Clofibrate"]
["N,N'-bis(dichloroacetyl)-1,8-octamethylenediamine",0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"N,N'-bis(dichloroacetyl)-1,8-octamethylenediamine"]
["SB 210661",1,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"SB 210661"]
["tert-4-hydroxy-2-nonenal",0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"tert-4-hydroxy-2-nonenal"]
["Urea",1,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Urea"]
["danthron",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,"danthron"]
["Dydrogesterone",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,"Dydrogesterone"]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  AF389,AF389)","v":"Etodolac"},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,"Etodolac"]
["latanoprost",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,"latanoprost"]
["Prostaglandins F, Synthetic",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,"Prostaglandins F, Synthetic"]
["arsenic trioxide",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"arsenic trioxide"]
["tamibarotene",0,0,0,13,0,0,0,0,0,0,0,7,0,3,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,"tamibarotene"]
["Dithizone",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Dithizone"]
["SU 11657",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"SU 11657"]
["troglitazone",0,0,0,6,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,7,0,0,0,0,"troglitazone"]
["2,4-thiazolidinedione",0,0,0,3,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,0,0,0,"2,4-thiazolidinedione"]
["ER 38925",0,0,0,3,0,0,0,0,0,0,0,3,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"ER 38925"]
["AGN 194204",0,0,0,2,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,0,0,0,"AGN 194204"]
["ALRT 1550",0,0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,"ALRT 1550"]
["CD 2019",0,0,0,2,0,0,0,0,0,0,0,1,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"CD 2019"]
["ciglitazone",0,0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,3,0,0,0,0,"ciglitazone"]
["ER 34617",0,0,0,2,0,0,0,0,0,0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"ER 34617"]
["luffariellolide",0,0,0,2,0,0,0,0,0,0,0,2,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"luffariellolide"]
["Palovarotene",0,0,0,2,0,0,0,0,0,0,0,0,0,0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Palovarotene"]
["(((4-(ethoxycarbonyl)phenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methan-1-one",0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,"(((4-(ethoxycarbonyl)phenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methan-1-one"]
["(((4-(ethoxycarbonyl)phenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methane-1-thione",0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,"(((4-(ethoxycarbonyl)phenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methane-1-thione"]
["(((4-nitrophenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methane-1-thione",0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,"(((4-nitrophenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methane-1-thione"]
["15-deoxyprostaglandin J2",0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,"15-deoxyprostaglandin J2"]
["3-(4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)tetrahydro-1-benzofuran-2-yl)-2-propenoic acid",0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,"3-(4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)tetrahydro-1-benzofuran-2-yl)-2-propenoic acid"]
["3,7-dimethyl-9-ferrocenylnona-2,4,6,8-tetraenoic acid",0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"3,7-dimethyl-9-ferrocenylnona-2,4,6,8-tetraenoic acid"]
["4-((3,5,5,8,8-pentamethyl--5,6,7,8-tetrahydro-2-naphthyl)carbonyl)benzoic acid O-methyloxime",0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,"4-((3,5,5,8,8-pentamethyl--5,6,7,8-tetrahydro-2-naphthyl)carbonyl)benzoic acid O-methyloxime"]
["4-((3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)carbonyl)benzoic acid oxime",0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,"4-((3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)carbonyl)benzoic acid oxime"]
["4-(3-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)phenyl)benzoic acid",0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,"4-(3-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)phenyl)benzoic acid"]
["4-(4-(2-(n-butoxy)ethoxy)-5-methylthiazol-2-yl)-2-fluorobenzoic acid",0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"4-(4-(2-(n-butoxy)ethoxy)-5-methylthiazol-2-yl)-2-fluorobenzoic acid"]
["4-(4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-quinoxalinyl)-1,3-thiazol-2-yl)benzoic acid",0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,"4-(4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-quinoxalinyl)-1,3-thiazol-2-yl)benzoic acid"]
["4-(5-(7-fluoro-4-(trifluoromethyl)benzo(b)furan-2-yl)-1H-2-pyrrolyl)benzoic acid",0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"4-(5-(7-fluoro-4-(trifluoromethyl)benzo(b)furan-2-yl)-1H-2-pyrrolyl)benzoic acid"]
["5'PPP-RNA",0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"5'PPP-RNA"]
["6-OH-11-O-hydroxyphenanthrene",0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,"6-OH-11-O-hydroxyphenanthrene"]
["6-tert-butyl-1,1-dimethylindanyl",0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,"6-tert-butyl-1,1-dimethylindanyl"]
["7-(1-(1-methylethyl)-1,2,3,4-tetrahydroquinolin-6-yl)-6-fluoro-3-methylnona-2,4,6-trienoic acid",0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,"7-(1-(1-methylethyl)-1,2,3,4-tetrahydroquinolin-6-yl)-6-fluoro-3-methylnona-2,4,6-trienoic acid"]
["7-hydroxyretinoic acid",0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"7-hydroxyretinoic acid"]
["AGN 191701",0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,"AGN 191701"]
["AGN 193835",0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,"AGN 193835"]
["AGN 195183",0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,"AGN 195183"]
["aminobenzothiazole compound",0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,"aminobenzothiazole compound"]
["benzofuran",0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"benzofuran"]
["BMS 649",0,0,0,1,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,"BMS 649"]
["BMS 961",0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"BMS 961"]
["carbazole",0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"carbazole"]
["carboprostacyclin",0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,"carboprostacyclin"]
["CD 666",0,0,0,1,0,0,0,0,0,0,0,1,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"CD 666"]
["Cyclic AMP",0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Cyclic AMP"]
["decalpenic acid",0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"decalpenic acid"]
["disila-tamibarotene",0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"disila-tamibarotene"]
["Epoprostenol",0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,"Epoprostenol"]
["ferrocene",0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"ferrocene"]
["HX 630",0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,0,0,0,"HX 630"]
["LG 100324",0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,"LG 100324"]
["LG 268",0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,"LG 268"]
["methyl 4-((2,3-dihydro-2,2,4,4-teetramethyl-2H-1-benzothiopyran-6-yl)carbamoyl)benzoate",0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,"methyl 4-((2,3-dihydro-2,2,4,4-teetramethyl-2H-1-benzothiopyran-6-yl)carbamoyl)benzoate"]
["MM11453",0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"MM11453"]
["nutlin 3",0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"nutlin 3"]
["p-(2-(N-butylcarbazol-3'-yl)ethen-1-yl)benzoic acid",0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"p-(2-(N-butylcarbazol-3'-yl)ethen-1-yl)benzoic acid"]
["p-(4-ferrocenylbuta-1,3-dien-1-yl)benzoic acid",0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"p-(4-ferrocenylbuta-1,3-dien-1-yl)benzoic acid"]
["Paclitaxel",0,0,0,1,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Paclitaxel"]
["Phytanic Acid",0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,"Phytanic Acid"]
["pimaric acid",0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"pimaric acid"]
["RNA, Viral",0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"RNA, Viral"]
["Roflumilast",0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Roflumilast"]
["Serotonin",0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Serotonin"]
["Sorbic Acid",0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Sorbic Acid"]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  AF453,AF453)","v":"SR-0065"},0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,"SR-0065"]
["Tamoxifen",0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Tamoxifen"]
["Thiourea",0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,"Thiourea"]
["TO-901317",0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,"TO-901317"]
["1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-1H-benzotriazole-5-carboxylic acid",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,"1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-1H-benzotriazole-5-carboxylic acid"]
["1-aminocyclopropanol",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"1-aminocyclopropanol"]
["1H-benzotriazole-5-carboxylic acid",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,"1H-benzotriazole-5-carboxylic acid"]
["2,2'-Dipyridyl",2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"2,2'-Dipyridyl"]
["2,2'-dipyridyl disulfide",2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"2,2'-dipyridyl disulfide"]
["2-aminothiazole",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"2-aminothiazole"]
["2-hydroxyethyl disulfide",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"2-hydroxyethyl disulfide"]
["3-amino-6-(3-aminopropyl)-5,6-dihydro-5,11-dioxo-11H-indeno(1,2-c)isoquinoline",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,"3-amino-6-(3-aminopropyl)-5,6-dihydro-5,11-dioxo-11H-indeno(1,2-c)isoquinoline"]
["4-dimethylaminoazobenzene-4'-iodoacetamide",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"4-dimethylaminoazobenzene-4'-iodoacetamide"]
["4-hydroxy-2-nonenal",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"4-hydroxy-2-nonenal"]
["5-(4-ethylpiperazin-1-ylmethyl)pyridin-2-yl)-(5-fluoro-4-(7-fluoro-3-isopropyl-2-methyl-3H-benzoimidazol-5-yl)pyrimidin-2-yl)amine",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"5-(4-ethylpiperazin-1-ylmethyl)pyridin-2-yl)-(5-fluoro-4-(7-fluoro-3-isopropyl-2-methyl-3H-benzoimidazol-5-yl)pyrimidin-2-yl)amine"]
["5-ethynyl-2(1H)-pyrimidinone",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"5-ethynyl-2(1H)-pyrimidinone"]
["7-(2-(2,2-difluoroethoxy)-3,5-di-tert-butylbenzene)-3-methylocta-2,4,6-trienoic acid",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,"7-(2-(2,2-difluoroethoxy)-3,5-di-tert-butylbenzene)-3-methylocta-2,4,6-trienoic acid"]
["9-(3-hydroxypropoxy)guanine",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"9-(3-hydroxypropoxy)guanine"]
["A1120 agent",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,"A1120 agent"]
["Acetaldehyde",8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Acetaldehyde"]
["Acetazolamide",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Acetazolamide"]
["Acetylcholine",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Acetylcholine"]
["Adapalene",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Adapalene"]
["afimoxifene",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"afimoxifene"]
["Allopurinol",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Allopurinol"]
["alpha-ketoisocaproic acid",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"alpha-ketoisocaproic acid"]
["Ammonium Chloride",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Ammonium Chloride"]
["Amphetamine",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,"Amphetamine"]
["Amsacrine",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Amsacrine"]
["Aspirin",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Aspirin"]
["Atropine",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Atropine"]
["Azaguanine",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Azaguanine"]
["Barium",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Barium"]
["Benserazide",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Benserazide"]
["Benzoic Acid",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Benzoic Acid"]
["Betaine",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Betaine"]
["betaine aldehyde",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"betaine aldehyde"]
["bexarotene-3-(hydroxymethyl)-5-methoxy-1,2-dimethyl-1H-indole-4,7-dione ester",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,"bexarotene-3-(hydroxymethyl)-5-methoxy-1,2-dimethyl-1H-indole-4,7-dione ester"]
["bigelovin",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,"bigelovin"]
["C.I. Solvent Yellow 56",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"C.I. Solvent Yellow 56"]
["Calcium",2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Calcium"]
["Carbon Disulfide",2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Carbon Disulfide"]
["Carbon Monoxide",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Carbon Monoxide"]
["carbonyl sulfide",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"carbonyl sulfide"]
["CD 3254",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,"CD 3254"]
["Celecoxib",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,"Celecoxib"]
["Cerulenin",2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Cerulenin"]
["Chitosan",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Chitosan"]
["Chloral Hydrate",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Chloral Hydrate"]
["chloramine",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"chloramine"]
["Chlorphenamidine",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Chlorphenamidine"]
["Cibacron Blue F 3GA",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Cibacron Blue F 3GA"]
["coenzyme Q10",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"coenzyme Q10"]
["Cyanamide",14,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Cyanamide"]
["Cyclophosphamide",3,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Cyclophosphamide"]
["Dacarbazine",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Dacarbazine"]
["decaborane",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,"decaborane"]
["Deoxycytidine",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,"Deoxycytidine"]
["dimethylcyanamide",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"dimethylcyanamide"]
["Dimethylformamide",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Dimethylformamide"]
["Disulfiram",33,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Disulfiram"]
["Ditiocarb",3,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Ditiocarb"]
["Dopamine",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Dopamine"]
["elaidic acid",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,"elaidic acid"]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  AF517,AF517)","v":"emixustat"},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"emixustat"]
["eniluracil",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"eniluracil"]
["Etoposide",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Etoposide"]
["Farnesol",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Farnesol"]
["farnesylamine",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"farnesylamine"]
["Fenofibrate",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,"Fenofibrate"]
["Fingolimod Hydrochloride",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Fingolimod Hydrochloride"]
["Formaldehyde",2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Formaldehyde"]
["fulvestrant",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"fulvestrant"]
["gemcitabine",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,"gemcitabine"]
["Glucose",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,"Glucose"]
["Glycerol",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Glycerol"]
["Gossypol",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Gossypol"]
["Guanine",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Guanine"]
["Haloperidol",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Haloperidol"]
["Hexobarbital",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Hexobarbital"]
["Histamine",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Histamine"]
["honokiol",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,2,0,0,0,0,"honokiol"]
["Hydralazine",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Hydralazine"]
["Hydroxyacetylaminofluorene",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Hydroxyacetylaminofluorene"]
["IIF compound",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,"IIF compound"]
["Indomethacin",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Indomethacin"]
["Iodoacetamide",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Iodoacetamide"]
["KN 93",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"KN 93"]
["LG 101208",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,"LG 101208"]
["Magnesium",3,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Magnesium"]
["Magnesium Chloride",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Magnesium Chloride"]
["Malondialdehyde",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Malondialdehyde"]
["Manganese",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Manganese"]
["Mescaline",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Mescaline"]
["Methadone",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Methadone"]
["Methamphetamine",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,"Methamphetamine"]
["Methanol",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Methanol"]
["Metronidazole",2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Metronidazole"]
["Misoprostol",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Misoprostol"]
["N6022",6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"N6022"]
["NAD",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"NAD"]
["Nafronyl",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Nafronyl"]
["Niacin",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,"Niacin"]
["Nickel",2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Nickel"]
["oleanane",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,"oleanane"]
["Oleanolic Acid",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,"Oleanolic Acid"]
["Oleic Acid",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,"Oleic Acid"]
["ONO 3307",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"ONO 3307"]
["osteum",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"osteum"]
["Ouabain",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Ouabain"]
["Oxygen",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,"Oxygen"]
["p-Aminoazobenzene",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"p-Aminoazobenzene"]
["p-Dimethylaminoazobenzene",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"p-Dimethylaminoazobenzene"]
["Pentobarbital",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Pentobarbital"]
["perfluorodecanoic acid",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"perfluorodecanoic acid"]
["perfosfamide",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"perfosfamide"]
["Phenylglyoxal",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Phenylglyoxal"]
["Phytol",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Phytol"]
["piperidine",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,"piperidine"]
["Pirenzepine",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Pirenzepine"]
["Potassium Cyanide",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Potassium Cyanide"]
["Proadifen",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Proadifen"]
["propiolaldehyde",3,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"propiolaldehyde"]
["propionic acid",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"propionic acid"]
["Propranolol",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Propranolol"]
["Pyrogallol",2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Pyrogallol"]
["Raloxifene Hydrochloride",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,"Raloxifene Hydrochloride"]
["Reserpine",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Reserpine"]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  AF581,AF581)","v":"retinyl bromoacetate"},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"retinyl bromoacetate"]
["retinylamine",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"retinylamine"]
["RNA, Messenger",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"RNA, Messenger"]
["roscovitine",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"roscovitine"]
["sanglifehrin A",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"sanglifehrin A"]
["Sesame Oil",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Sesame Oil"]
["shikonin",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"shikonin"]
["Silicon",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,"Silicon"]
["sodium sulfide",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"sodium sulfide"]
["Spermidine",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Spermidine"]
["Spermine",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Spermine"]
["Spironolactone",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,"Spironolactone"]
["SPL-334",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"SPL-334"]
["SR 11237",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,"SR 11237"]
["Staurosporine",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Staurosporine"]
["Tetraethylammonium",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Tetraethylammonium"]
["Thallium",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Thallium"]
["trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride"]
["Trichloroethylene",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Trichloroethylene"]
["trifluoroacetaldehyde hydrate",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"trifluoroacetaldehyde hydrate"]
["Trimeprazine",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Trimeprazine"]
["Ubiquinone",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Ubiquinone"]
["Uracil",1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Uracil"]
["UVI 3003",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,0,0,"UVI 3003"]
["Valproic Acid",6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Valproic Acid"]
["Vitamin B 12",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Vitamin B 12"]
["Vitamin E",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Vitamin E"]
["Vitamin K 1",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,"Vitamin K 1"]

{"sheet":"Detail","index":2,"n_rows":1888,"n_cols":10,"rows_kept":1888,"cut":false,"hidden":false,"merged":[]}
["Detail"]
["Chemical","col","Target","ag / antag","PMID","Pub Yr","Title","pmid","ChemName","Target"]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  I3,I3)","v":"(((4-(ethoxycarbonyl)phenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methan-1-one"},{"$f":"C3&\"_\"&D3","v":"Receptors, Retinoic Acid_ag"},{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  J3,J3)","v":"Receptors, Retinoic Acid"},"ag",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & H3,H3)","v":"16133793"},2005,"Flexible heteroarotinoids (Flex-Hets) exhibit improved therapeutic ratios as anti-cancer agents over retinoic acid receptor agonists.","16133793","(((4-(ethoxycarbonyl)phenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methan-1-one","Receptors, Retinoic Acid"]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  I4,I4)","v":"(((4-(ethoxycarbonyl)phenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methan-1-one"},"Retinoid X Receptors_ag",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  J4,J4)","v":"Retinoid X Receptors"},"ag",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & H4,H4)","v":"16133793"},2005,"Flexible heteroarotinoids (Flex-Hets) exhibit improved therapeutic ratios as anti-cancer agents over retinoic acid receptor agonists.","16133793","(((4-(ethoxycarbonyl)phenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methan-1-one","Retinoid X Receptors"]
["(((4-(ethoxycarbonyl)phenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methane-1-thione","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","16133793",2005,"Flexible heteroarotinoids (Flex-Hets) exhibit improved therapeutic ratios as anti-cancer agents over retinoic acid receptor agonists.","16133793","(((4-(ethoxycarbonyl)phenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methane-1-thione","Receptors, Retinoic Acid"]
["(((4-(ethoxycarbonyl)phenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methane-1-thione","Retinoid X Receptors_ag","Retinoid X Receptors","ag","16133793",2005,"Flexible heteroarotinoids (Flex-Hets) exhibit improved therapeutic ratios as anti-cancer agents over retinoic acid receptor agonists.","16133793","(((4-(ethoxycarbonyl)phenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methane-1-thione","Retinoid X Receptors"]
["(((4-nitrophenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methane-1-thione","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","16133793",2005,"Flexible heteroarotinoids (Flex-Hets) exhibit improved therapeutic ratios as anti-cancer agents over retinoic acid receptor agonists.","16133793","(((4-nitrophenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methane-1-thione","Receptors, Retinoic Acid"]
["(((4-nitrophenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methane-1-thione","Retinoid X Receptors_ag","Retinoid X Receptors","ag","16133793",2005,"Flexible heteroarotinoids (Flex-Hets) exhibit improved therapeutic ratios as anti-cancer agents over retinoic acid receptor agonists.","16133793","(((4-nitrophenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methane-1-thione","Retinoid X Receptors"]
["(E)-1-(2-nitrovinyl)naphthalene","Retinoid X Receptor alpha_ag","Retinoid X Receptor alpha","ag","25795708",2015,"Nitrostyrene Derivatives Act as RXRα Ligands to Inhibit TNFα Activation of NF-κB.","25795708","(E)-1-(2-nitrovinyl)naphthalene","Retinoid X Receptor alpha"]
["(E)-9-(2-nitrovinyl)anthracene","Retinoid X Receptor alpha_ag","Retinoid X Receptor alpha","ag","25795708",2015,"Nitrostyrene Derivatives Act as RXRα Ligands to Inhibit TNFα Activation of NF-κB.","25795708","(E)-9-(2-nitrovinyl)anthracene","Retinoid X Receptor alpha"]
["1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-1H-benzotriazole-5-carboxylic acid","Retinoid X Receptors_ag","Retinoid X Receptors","ag","23391145",2013,"Mechanism of retinoid X receptor partial agonistic action of 1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-1H-benzotriazole-5-carboxylic acid and structural development to increase potency.","23391145","1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-1H-benzotriazole-5-carboxylic acid","Retinoid X Receptors"]
["1,2,4-triazine","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","22414679",2012,"Synthesis and structure elucidation of novel fused 1,2,4-triazine derivatives as potent inhibitors targeting CYP1A1 activity.","22414679","1,2,4-triazine","Cytochrome P-450 CYP1A1"]
["1,2,4-trihydroxy-9,10-anthracenedione","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","12379470",2002,"Inhibition of human cytochrome P450 1B1, 1A1 and 1A2 by antigenotoxic compounds, purpurin and alizarin.","12379470","1,2,4-trihydroxy-9,10-anthracenedione","Cytochrome P-450 CYP1A1"]
["1,3-benzodioxole","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","7701515",1995,"Computer graphics analysis of the interaction of alkoxy methylenedioxybenzenes with cytochromes P4501.","7701515","1,3-benzodioxole","Cytochrome P-450 CYP1A1"]
["1,4-phenylenebis(methylene)selenocyanate","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","21732699",2011,"Spectral modification and catalytic inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2A6, and 2A13 by four chemopreventive organoselenium compounds.","21732699","1,4-phenylenebis(methylene)selenocyanate","Cytochrome P-450 CYP1A1"]
["13,14-dihydroretinoic acid","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","19770350",2009,"Activation of retinoic acid receptors by dihydroretinoids.","19770350","13,14-dihydroretinoic acid","Receptors, Retinoic Acid"]
["13,14-dihydroretinoic acid","retinoic acid binding protein II, cellular_ag","retinoic acid binding protein II, cellular","ag","19770350",2009,"Activation of retinoic acid receptors by dihydroretinoids.","19770350","13,14-dihydroretinoic acid","retinoic acid binding protein II, cellular"]
["15-deoxy-delta(12,14)-prostaglandin J2","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","11728177",2001,"Stimulated release of arachidonic acid by agonists of the peroxisome proliferator-activated receptor and retinoic acid receptors.","11728177","15-deoxy-delta(12,14)-prostaglandin J2","Receptors, Retinoic Acid"]
["15-deoxy-delta(12,14)-prostaglandin J2","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","24098526",2013,"Amplified inhibition of stellate cell activation pathways by PPAR-γ, RAR and RXR agonists.","24098526","15-deoxy-delta(12,14)-prostaglandin J2","Receptors, Retinoic Acid"]
["15-deoxy-delta(12,14)-prostaglandin J2","Retinoid X Receptors_antag","Retinoid X Receptors","antag","24098526",2013,"Amplified inhibition of stellate cell activation pathways by PPAR-γ, RAR and RXR agonists.","24098526","15-deoxy-delta(12,14)-prostaglandin J2","Retinoid X Receptors"]
["15-deoxyprostaglandin J2","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","14975592",2004,"Ligands for the peroxisome proliferator-activated receptor-gamma and the retinoid X receptor exert additive anti-inflammatory effects on experimental autoimmune encephalomyelitis.","14975592","15-deoxyprostaglandin J2","Receptors, Retinoic Acid"]
["15-deoxyprostaglandin J2","Retinoid X Receptors_ag","Retinoid X Receptors","ag","14975592",2004,"Ligands for the peroxisome proliferator-activated receptor-gamma and the retinoid X receptor exert additive anti-inflammatory effects on experimental autoimmune encephalomyelitis.","14975592","15-deoxyprostaglandin J2","Retinoid X Receptors"]
["1-aminobenzotriazole","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","2276091",1990,"N-aralkylated derivatives of 1-aminobenzotriazole as isozyme-selective, mechanism-based inhibitors of guinea pig hepatic cytochrome P-450 dependent monooxygenase activity.","2276091","1-aminobenzotriazole","Cytochrome P-450 CYP1A1"]
["1-aminobenzotriazole","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","8050632",1994,"A 13-week toxicologic and pathologic evaluation of prolonged cytochromes P450 inhibition by 1-aminobenzotriazole in male rats.","8050632","1-aminobenzotriazole","Cytochrome P-450 CYP1A1"]
["1-aminobenzotriazole","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","8246152",1993,"Mechanism-based inactivation of cytochrome P450 1A1 by N-aralkyl-1-aminobenzotriazoles in guinea pig kidney in vivo and in vitro: minimal effects on metabolism of arachidonic acid by renal P450-dependent monooxygenases.","8246152","1-aminobenzotriazole","Cytochrome P-450 CYP1A1"]
["1-aminocyclopropanol","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","6870943",1983,"Studies in vitro on the inactivation of mitochondrial rat-liver aldehyde dehydrogenase by the alcohol-sensitizing compounds cyanamide, 1-aminocyclopropanol and disulfiram.","6870943","1-aminocyclopropanol","Aldehyde Oxidoreductases"]
["1-ethynylpyrene","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","8069946",1994,"Interaction of 1-ethynylpyrene and hepatic CYPIA1 from rainbow trout.","8069946","1-ethynylpyrene","Cytochrome P-450 CYP1A1"]
["1-ethynylpyrene","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","8448348",1993,"Determinants of protein modification versus heme alkylation: inactivation of cytochrome P450 1A1 by 1-ethynylpyrene and phenylacetylene.","8448348","1-ethynylpyrene","Cytochrome P-450 CYP1A1"]
["1-furan-2-yl-3-pyridin-2-yl-propenone","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","18255114",2008,"Chemopreventive effects of Furan-2-yl-3-pyridin-2-yl-propenone against 7,12-dimethylbenz[a]anthracene-inducible genotoxicity.","18255114","1-furan-2-yl-3-pyridin-2-yl-propenone","Cytochrome P-450 CYP1A1"]
["1H-benzotriazole-5-carboxylic acid","Retinoid X Receptors_ag","Retinoid X Receptors","ag","23391145",2013,"Mechanism of retinoid X receptor partial agonistic action of 1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-1H-benzotriazole-5-carboxylic acid and structural development to increase potency.","23391145","1H-benzotriazole-5-carboxylic acid","Retinoid X Receptors"]
["1-isopropyloxygenipin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","23940731",2013,"Requirement of retinoic acid receptor β for genipin derivative-induced optic nerve regeneration in adult rat retina.","23940731","1-isopropyloxygenipin","Receptors, Retinoic Acid"]
["1-isopropyloxygenipin","retinoic acid receptor beta_antag","retinoic acid receptor beta","antag","23940731",2013,"Requirement of retinoic acid receptor β for genipin derivative-induced optic nerve regeneration in adult rat retina.","23940731","1-isopropyloxygenipin","retinoic acid receptor beta"]
["1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","1468127",1992,"Effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its toxic metabolites on the physicochemical property of the liposomal membrane in relation to their cytochrome P-450 inhibition.","1468127","1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine","Cytochrome P-450 CYP1A1"]
["1-methyl-4-phenyl-2,3-dihydropyridinium","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","1468127",1992,"Effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its toxic metabolites on the physicochemical property of the liposomal membrane in relation to their cytochrome P-450 inhibition.","1468127","1-methyl-4-phenyl-2,3-dihydropyridinium","Cytochrome P-450 CYP1A1"]
["1-Methyl-4-phenylpyridinium","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","1468127",1992,"Effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its toxic metabolites on the physicochemical property of the liposomal membrane in relation to their cytochrome P-450 inhibition.","1468127","1-Methyl-4-phenylpyridinium","Cytochrome P-450 CYP1A1"]
["1-nitropyrene","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","22044530",2011,"2,3,7,8-Tetrachlorodibenzo-p-dioxin's suppression of 1-nitropyrene-induced p53 expression is mediated by cytochrome P450 1A1.","22044530","1-nitropyrene","Cytochrome P-450 CYP1A1"]
["1-phenylcyclohex-1-ene","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","11277515",2001,"Phenylcyclohexene and phenylcyclohexadiene substituted compounds having retinoid antagonist activity.","11277515","1-phenylcyclohex-1-ene","Receptors, Retinoic Acid"]
["2-((2,6-dichlorophenyl)amino)benzeneacetic acid 4-(3H-1,2-dithiol-3-thione-5-yl)phenyl ester","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","19276279",2009,"Novel dithiolethione-modified nonsteroidal anti-inflammatory drugs in human hepatoma HepG2 and colon LS180 cells.","19276279","2-((2,6-dichlorophenyl)amino)benzeneacetic acid 4-(3H-1,2-dithiol-3-thione-5-yl)phenyl ester","Cytochrome P-450 CYP1A1"]
["2,2',4,6,6'-pentachlorobiphenyl","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","19549508",2009,"PCB-induced endothelial cell dysfunction: role of poly(ADP-ribose) polymerase.","19549508","2,2',4,6,6'-pentachlorobiphenyl","Cytochrome P-450 CYP1A1"]
["2,2',4,6'-tetramethoxystilbene","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","19463925",2009,"Potent inhibition of human cytochrome P450 1B1 by tetramethoxystilbene.","19463925","2,2',4,6'-tetramethoxystilbene","Cytochrome P-450 CYP1A1"]
["2,2-dimethyl-3-(4-(naphthalen-2-ylamino)phenyl)-3-(1,2,4)triazol-1-yl-propionic acid methyl ester","retinoic acid 4-hydroxylase_antag","retinoic acid 4-hydroxylase","antag","21838328",2011,"Synthesis and biological evaluation of 3-(1H-imidazol- and triazol-1-yl)-2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]propyl derivatives as small molecule inhibitors of retinoic acid 4-hydroxylase (CYP26).","21838328","2,2-dimethyl-3-(4-(naphthalen-2-ylamino)phenyl)-3-(1,2,4)triazol-1-yl-propionic acid methyl ester","retinoic acid 4-hydroxylase"]
["2,2'-Dipyridyl","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","540042",1979,"2,2'-Dithiodipyridine activates aldehyde dehydrogenase and protects the enzyme against inactivation by disulfiram.","540042","2,2'-Dipyridyl","Aldehyde Oxidoreductases"]
["2,2'-Dipyridyl","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","7115312",1982,"Further studies of the action of disulfiram and 2,2'-dithiodipyridine on the dehydrogenase and esterase activities of sheep liver cytoplasmic aldehyde dehydrogenase.","7115312","2,2'-Dipyridyl","Aldehyde Oxidoreductases"]
["2,2'-dipyridyl disulfide","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","540042",1979,"2,2'-Dithiodipyridine activates aldehyde dehydrogenase and protects the enzyme against inactivation by disulfiram.","540042","2,2'-dipyridyl disulfide","Aldehyde Oxidoreductases"]
["2,2'-dipyridyl disulfide","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","7115312",1982,"Further studies of the action of disulfiram and 2,2'-dithiodipyridine on the dehydrogenase and esterase activities of sheep liver cytoplasmic aldehyde dehydrogenase.","7115312","2,2'-dipyridyl disulfide","Aldehyde Oxidoreductases"]
["2,3,7,8-tetrabromodibenzo-4-dioxin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","16540597",2006,"Novel compound 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl)-amide (CH-223191) prevents 2,3,7,8-TCDD-induced toxicity by antagonizing the aryl hydrocarbon receptor.","16540597","2,3,7,8-tetrabromodibenzo-4-dioxin","Cytochrome P-450 CYP1A1"]
["2,4,5,2',4',5'-hexachlorobiphenyl","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","19386251",2009,"Effect of PCB153 on BaP-induced genotoxicity in HepG2 cells via modulation of metabolic enzymes.","19386251","2,4,5,2',4',5'-hexachlorobiphenyl","Cytochrome P-450 CYP1A1"]
["2,4-thiazolidinedione","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","11145125",2000,"The effects of rexinoids and rosiglitazone on body weight and uncoupling protein isoform expression in the Zucker fa/fa rat.","11145125","2,4-thiazolidinedione","Receptors, Retinoic Acid"]
["2,4-thiazolidinedione","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","11728177",2001,"Stimulated release of arachidonic acid by agonists of the peroxisome proliferator-activated receptor and retinoic acid receptors.","11728177","2,4-thiazolidinedione","Receptors, Retinoic Acid"]
["2,4-thiazolidinedione","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","11872672",2002,"Regional differences in the response of human pre-adipocytes to PPARgamma and RXRalpha agonists.","11872672","2,4-thiazolidinedione","Receptors, Retinoic Acid"]
["2,4-thiazolidinedione","Retinoid X Receptors_ag","Retinoid X Receptors","ag","11145125",2000,"The effects of rexinoids and rosiglitazone on body weight and uncoupling protein isoform expression in the Zucker fa/fa rat.","11145125","2,4-thiazolidinedione","Retinoid X Receptors"]
["2,4-thiazolidinedione","Retinoid X Receptors_ag","Retinoid X Receptors","ag","11872672",2002,"Regional differences in the response of human pre-adipocytes to PPARgamma and RXRalpha agonists.","11872672","2,4-thiazolidinedione","Retinoid X Receptors"]
["2,5,2',5'-tetrachlorobiphenyl","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","24397434",2014,"Complex interactions between dioxin-like and non-dioxin-like compounds for in vitro cellular responses: implications for the identification of dioxin exposure biomarkers.","24397434","2,5,2',5'-tetrachlorobiphenyl","Cytochrome P-450 CYP1A1"]
["24,25-epoxycholesterol","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","11371634",2001,"Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR.","11371634","24,25-epoxycholesterol","Receptors, Retinoic Acid"]
["2-Acetylaminofluorene","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","3741414",1986,"N-hydroxy-2-acetylaminofluorene as effective inhibitor of aldehyde oxidase.","3741414","2-Acetylaminofluorene","Aldehyde Oxidoreductases"]
["2-Acetylaminofluorene","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","11888708",2002,"Acute cytotoxicity of the chemical carcinogen 2-acetylaminofluorene in cultured rat liver epithelial cells.","11888708","2-Acetylaminofluorene","Cytochrome P-450 CYP1A1"]
["2-amino-3,4-dimethylimidazo(4,5-f)quinoline","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","11752233",2002,"Flavonoids inhibit genetic toxicity produced by carcinogens in cells expressing CYP1A2 and CYP1A1.","11752233","2-amino-3,4-dimethylimidazo(4,5-f)quinoline","Cytochrome P-450 CYP1A1"]
["2-aminothiazole","Retinoblastoma Protein_antag","Retinoblastoma Protein","antag","20372067",2010,"Biological characterization of 2-aminothiazole-derived Cdk4/6 selective inhibitor in vitro and in vivo.","20372067","2-aminothiazole","Retinoblastoma Protein"]
["2-anthramine","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","16006184",2005,"The spectrum of enzymes involved in activation of 2-aminoanthracene varies with the metabolic system applied.","16006184","2-anthramine","Cytochrome P-450 CYP1A1"]
["2-anthramine","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","8545829",1995,"Aminoanthracene is a mechanism-based inactivator of CYP1A in channel catfish hepatic tissue.","8545829","2-anthramine","Cytochrome P-450 CYP1A1"]
["2-butenal","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","3089300",1986,"Inhibition of CO2 production from aminopyrine or methanol by cyanamide or crotonaldehyde and the role of mitochondrial aldehyde dehydrogenase in formaldehyde oxidation.","3089300","2-butenal","Aldehyde Oxidoreductases"]
["2-butenal","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","3103627",1987,"Inhibition of microsomal cytochrome c reductase activity by a series of alpha, beta-unsaturated aldehydes.","3103627","2-butenal","Cytochrome P-450 CYP1A1"]
["2-chloroethyl ethyl sulfide","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","20561902",2010,"Inhibition of NADPH cytochrome P450 reductase by the model sulfur mustard vesicant 2-chloroethyl ethyl sulfide is associated with increased production of reactive oxygen species.","20561902","2-chloroethyl ethyl sulfide","Cytochrome P-450 CYP1A1"]
["2-ethynylnaphthalene","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","1510726",1992,"Suicide inhibitors of cytochrome P450 1A1 and P450 2B1.","1510726","2-ethynylnaphthalene","Cytochrome P-450 CYP1A1"]
["2-fluoro-4-(((8-bromo-2,2-dimethyl-4-(4-methylphenyl)chroman-6-yl)carbonyl)amino)benzoic acid","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","23474897",2013,"Practical synthesis of a chromene analog for use as a retinoic acid receptor alpha antagonist lead compound.","23474897","2-fluoro-4-(((8-bromo-2,2-dimethyl-4-(4-methylphenyl)chroman-6-yl)carbonyl)amino)benzoic acid","Receptors, Retinoic Acid"]
["2-fluoro-4-(((8-bromo-2,2-dimethyl-4-(4-methylphenyl)chroman-6-yl)carbonyl)amino)benzoic acid","retinoic acid receptor alpha_antag","retinoic acid receptor alpha","antag","23474897",2013,"Practical synthesis of a chromene analog for use as a retinoic acid receptor alpha antagonist lead compound.","23474897","2-fluoro-4-(((8-bromo-2,2-dimethyl-4-(4-methylphenyl)chroman-6-yl)carbonyl)amino)benzoic acid","retinoic acid receptor alpha"]
["2-hydroxy-3-methoxyestradiol",{"$f":"C67&\"_\"&D67","v":"Cytochrome P-450 CYP1A1_antag"},"Cytochrome P-450 CYP1A1","antag","12810639",2003,"Methoxyestrogens exert feedback inhibition on cytochrome P450 1A1 and 1B1.","12810639","2-hydroxy-3-methoxyestradiol","Cytochrome P-450 CYP1A1"]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  I68,I68)","v":"2-hydroxyethyl disulfide"},"Aldehyde Oxidoreductases_antag",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  J68,J68)","v":"Aldehyde Oxidoreductases"},"antag",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & H68,H68)","v":"7267735"},1980,"Reversible inactivation of horse liver aldehyde dehydrogenase by 2-hydroxyethyl disulfide.","7267735","2-hydroxyethyl disulfide","Aldehyde Oxidoreductases"]
["2-methoxyestradiol","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","12810639",2003,"Methoxyestrogens exert feedback inhibition on cytochrome P450 1A1 and 1B1.","12810639","2-methoxyestradiol","Cytochrome P-450 CYP1A1"]
["2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","16540597",2006,"Novel compound 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl)-amide (CH-223191) prevents 2,3,7,8-TCDD-induced toxicity by antagonizing the aryl hydrocarbon receptor.","16540597","2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide","Cytochrome P-450 CYP1A1"]
["2-Naphthylamine","retinoic acid 4-hydroxylase_antag","retinoic acid 4-hydroxylase","antag","21838328",2011,"Synthesis and biological evaluation of 3-(1H-imidazol- and triazol-1-yl)-2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]propyl derivatives as small molecule inhibitors of retinoic acid 4-hydroxylase (CYP26).","21838328","2-Naphthylamine","retinoic acid 4-hydroxylase"]
["2-Naphthylamine","Retinoid X Receptors_ag","Retinoid X Receptors","ag","26714014",2015,"Effects of RXR Agonists on Cell Proliferation/Apoptosis and ACTH Secretion/Pomc Expression.","26714014","2-Naphthylamine","Retinoid X Receptors"]
["2-oxohexyl isothiocyanate","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","19202560",2009,"Sulforaphane and its analogues inhibit CYP1A1 and CYP1A2 activity induced by benzo[a]pyrene.","19202560","2-oxohexyl isothiocyanate","Cytochrome P-450 CYP1A1"]
["2-phenylphenanthridinone","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","8080264",1994,"2-Phenylphenanthridinone and related compounds: aryl hydrocarbon receptor agonists and suicide inactivators of P4501A1.","8080264","2-phenylphenanthridinone","Cytochrome P-450 CYP1A1"]
["2-toluidine","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","12604171",2003,"Effect of naturally occurring plant phenolics on the induction of drug metabolizing enzymes by o-toluidine.","12604171","2-toluidine","Cytochrome P-450 CYP1A1"]
["3-(2-(2,4,6-trimethylphenyl)thioethyl)-4-methylsydnone","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","7763287",1995,"Inactivation of chick embryo hepatic cytochrome P450 1A, 2H and 3A following in ovo administration of 3,5-diethoxycarbonyl-1,4-dihydro-2,6-dimethyl-4-ethylpyridine and 3-[2-(2,4,6-trimethylphenyl)thioethyl]-4-methylsydnone.","7763287","3-(2-(2,4,6-trimethylphenyl)thioethyl)-4-methylsydnone","Cytochrome P-450 CYP1A1"]
["3-(2-ethylphenyl)-5-(3-methoxyphenyl)-1H,2,4-triazol","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","19694183",2009,"Inhibitive effect of diphenytriazol on rat cytochrome P450 enzyme in vitro.","19694183","3-(2-ethylphenyl)-5-(3-methoxyphenyl)-1H,2,4-triazol","Cytochrome P-450 CYP1A1"]
["3-(4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)tetrahydro-1-benzofuran-2-yl)-2-propenoic acid","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","15056000",2004,"Structure-based design of potent retinoid X receptor alpha agonists.","15056000","3-(4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)tetrahydro-1-benzofuran-2-yl)-2-propenoic acid","Receptors, Retinoic Acid"]
["3-(4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)tetrahydro-1-benzofuran-2-yl)-2-propenoic acid","Retinoid X Receptors_ag","Retinoid X Receptors","ag","15056000",2004,"Structure-based design of potent retinoid X receptor alpha agonists.","15056000","3-(4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)tetrahydro-1-benzofuran-2-yl)-2-propenoic acid","Retinoid X Receptors"]
["3-(6-(2-dimethylamino-1-imidazol-1-yl-butyl)naphthalen-2-yloxy)-2,2-dimethyl-propionic acid","retinoic acid 4-hydroxylase_antag","retinoic acid 4-hydroxylase","antag","16504501",2006,"3-[6-(2-Dimethylamino-1-imidazol-1-yl-butyl)-naphthalen-2-yloxy]-2,2-dimethyl-propionic acid as a highly potent and selective retinoic acid metabolic blocking agent.","16504501","3-(6-(2-dimethylamino-1-imidazol-1-yl-butyl)naphthalen-2-yloxy)-2,2-dimethyl-propionic acid","retinoic acid 4-hydroxylase"]
["3-(alpha,alpha-dimethylallyl)psoralen","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","23257392",2013,"Mechanism-based inhibition of CYP1A1 and CYP3A4 by the furanocoumarin chalepensin.","23257392","3-(alpha,alpha-dimethylallyl)psoralen","Cytochrome P-450 CYP1A1"]
["3,3',4,5'-tetrahydroxystilbene","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","19356012",2007,"In vitro inhibition of rat CYP1A1 and CYP1A2 by piceatannol, a hydroxylated metabolite of trans-resveratrol.","19356012","3,3',4,5'-tetrahydroxystilbene","Cytochrome P-450 CYP1A1"]
["3,3'-diindolylmethane","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","11294972",2001,"2,3,7,8-Tetrachlorodibenzo-p-dioxin and diindolylmethanes differentially induce cytochrome P450 1A1, 1B1, and 19 in H295R human adrenocortical carcinoma cells.","11294972","3,3'-diindolylmethane","Cytochrome P-450 CYP1A1"]
["3,3'-diindolylmethane","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","8568833",1995,"The anticarcinogen 3,3'-diindolylmethane is an inhibitor of cytochrome P-450.","8568833","3,3'-diindolylmethane","Cytochrome P-450 CYP1A1"]
["3,4,3',4'-tetrachlorobiphenyl","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","10462547",1999,"Oxidative inactivation of cytochrome P-450 1A (CYP1A) stimulated by 3,3',4,4'-tetrachlorobiphenyl: production of reactive oxygen by vertebrate CYP1As.","10462547","3,4,3',4'-tetrachlorobiphenyl","Cytochrome P-450 CYP1A1"]
["3,4,3',4'-tetrachlorobiphenyl","lecithin-retinol acyltransferase_antag","lecithin-retinol acyltransferase","antag","10336091",1999,"Esterification and hydrolysis of vitamin A in the liver of brook trout (Salvelinus fontinalis) and the influence of a coplanar polychlorinated biphenyl.","10336091","3,4,3',4'-tetrachlorobiphenyl","lecithin-retinol acyltransferase"]
["3,4,3',4'-tetrachlorobiphenyl","retinol-palmitate esterase_antag","retinol-palmitate esterase","antag","10336091",1999,"Esterification and hydrolysis of vitamin A in the liver of brook trout (Salvelinus fontinalis) and the influence of a coplanar polychlorinated biphenyl.","10336091","3,4,3',4'-tetrachlorobiphenyl","retinol-palmitate esterase"]
["3,4,3',4'-tetrachlorobiphenyl","retinyl esterase_antag","retinyl esterase","antag","2123403",1990,"Retinyl ester hydrolase and vitamin A status in rats treated with 3,3',4, 4'-tetrachlorobiphenyl.","2123403","3,4,3',4'-tetrachlorobiphenyl","retinyl esterase"]
["3,4,5,3',4'-pentachlorobiphenyl","CYP1A1 protein, human_antag","CYP1A1 protein, human","antag","24355420",2014,"Hypoxia perturbs aryl hydrocarbon receptor signaling and CYP1A1 expression induced by PCB 126 in human skin and liver-derived cell lines.","24355420","3,4,5,3',4'-pentachlorobiphenyl","CYP1A1 protein, human"]
["3,4,5,3',4'-pentachlorobiphenyl","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","11164533",2001,"Induction and suppression of cytochrome P450 1A by 3,3',4,4',5-pentachlorobiphenyl and its relationship to oxidative stress in the marine fish scup (Stenotomus chrysops).","11164533","3,4,5,3',4'-pentachlorobiphenyl","Cytochrome P-450 CYP1A1"]
["3,4,5,3',4'-pentachlorobiphenyl","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","16219370",2005,"Effects of 17beta-estradiol, 4-nonylphenol and PCB 126 on the estrogenic activity and phase 1 and 2 biotransformation enzymes in male sea bass (Dicentrarchus labrax).","16219370","3,4,5,3',4'-pentachlorobiphenyl","Cytochrome P-450 CYP1A1"]
["3,4,5,3',4'-pentachlorobiphenyl","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","24355420",2014,"Hypoxia perturbs aryl hydrocarbon receptor signaling and CYP1A1 expression induced by PCB 126 in human skin and liver-derived cell lines.","24355420","3,4,5,3',4'-pentachlorobiphenyl","Cytochrome P-450 CYP1A1"]
["3,4,5,3',4'-pentachlorobiphenyl","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","9829560",1998,"Interaction of tributyltin with 3,3',4,4',5-pentachlorobiphenyl-induced ethoxyresorufin O-deethylase activity in rat hepatoma cells.","9829560","3,4,5,3',4'-pentachlorobiphenyl","Cytochrome P-450 CYP1A1"]
["3',4'-dimethoxyflavone","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","16484233",2006,"Inhibition of benzo[a]pyrene-activating enzymes and DNA binding in human bronchial epithelial BEAS-2B cells by methoxylated flavonoids.","16484233","3',4'-dimethoxyflavone","Cytochrome P-450 CYP1A1"]
["3,5-dicarbethoxy-2,6-dimethyl-4-ethyl-1,4-dihydropyridine","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","7763287",1995,"Inactivation of chick embryo hepatic cytochrome P450 1A, 2H and 3A following in ovo administration of 3,5-diethoxycarbonyl-1,4-dihydro-2,6-dimethyl-4-ethylpyridine and 3-[2-(2,4,6-trimethylphenyl)thioethyl]-4-methylsydnone.","7763287","3,5-dicarbethoxy-2,6-dimethyl-4-ethyl-1,4-dihydropyridine","Cytochrome P-450 CYP1A1"]
["3,5-dihydroxy-4'-methoxystilbene","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","17440990",2007,"Inhibition of human recombinant cytochromes P450 CYP1A1 and CYP1B1 by trans-resveratrol methyl ethers.","17440990","3,5-dihydroxy-4'-methoxystilbene","Cytochrome P-450 CYP1A1"]
["3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","12807734",2003,"Molecular mechanism for growth suppression of human hepatocellular carcinoma cells by acyclic retinoid.","12807734","3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid","Receptors, Retinoic Acid"]
["3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","18466769",2008,"Acyclic retinoid inhibits functional interaction of transcription factors Krüppel-like factor 5 and retinoic acid receptor-alpha.","18466769","3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid","Receptors, Retinoic Acid"]
["3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid","retinoic acid receptor alpha_antag","retinoic acid receptor alpha","antag","18466769",2008,"Acyclic retinoid inhibits functional interaction of transcription factors Krüppel-like factor 5 and retinoic acid receptor-alpha.","18466769","3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid","retinoic acid receptor alpha"]
["3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid","Retinoid X Receptors_antag","Retinoid X Receptors","antag","12807734",2003,"Molecular mechanism for growth suppression of human hepatocellular carcinoma cells by acyclic retinoid.","12807734","3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid","Retinoid X Receptors"]
["3,7-dimethyl-9-ferrocenylnona-2,4,6,8-tetraenoic acid","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","21506276",2011,"Design and stereoselective synthesis of retinoids with ferrocene or N-butylcarbazole pharmacophores that induce post-differentiation apoptosis in acute promyelocytic leukemia cells.","21506276","3,7-dimethyl-9-ferrocenylnona-2,4,6,8-tetraenoic acid","Receptors, Retinoic Acid"]
["3,7-dimethyl-9-ferrocenylnona-2,4,6,8-tetraenoic acid","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","21506276",2011,"Design and stereoselective synthesis of retinoids with ferrocene or N-butylcarbazole pharmacophores that induce post-differentiation apoptosis in acute promyelocytic leukemia cells.","21506276","3,7-dimethyl-9-ferrocenylnona-2,4,6,8-tetraenoic acid","retinoic acid receptor alpha"]
["3-amino-6-(3-aminopropyl)-5,6-dihydro-5,11-dioxo-11H-indeno(1,2-c)isoquinoline","Retinoid X Receptors_ag","Retinoid X Receptors","ag","21464033",2011,"Induction of retinoid X receptor activity and consequent upregulation of p21WAF1/CIP1 by indenoisoquinolines in MCF7 cells.","21464033","3-amino-6-(3-aminopropyl)-5,6-dihydro-5,11-dioxo-11H-indeno(1,2-c)isoquinoline","Retinoid X Receptors"]
["3-methoxy-4'-methylthiostilbene","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","18435436",2008,"Thiomethylstilbenes as inhibitors of CYP1A1, CYP1A2 and CYP1B1 activities.","18435436","3-methoxy-4'-methylthiostilbene","Cytochrome P-450 CYP1A1"]
["3'-methoxy-4'-nitroflavone","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","10825463",2000,"Effect of 3'-methoxy-4'-nitroflavone on benzo[a]pyrene toxicity. Aryl hydrocarbon receptor-dependent and -independent mechanisms.","10825463","3'-methoxy-4'-nitroflavone","Cytochrome P-450 CYP1A1"]
["3-methyladenine","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","24659340",2014,"Comparative study of autophagy inhibition by 3MA and CQ  on Cytarabine‑induced death of leukaemia cells.","24659340","3-methyladenine","Receptors, Retinoic Acid"]
["3-methyladenine","retinoic acid receptor alpha_antag","retinoic acid receptor alpha","antag","24659340",2014,"Comparative study of autophagy inhibition by 3MA and CQ  on Cytarabine‑induced death of leukaemia cells.","24659340","3-methyladenine","retinoic acid receptor alpha"]
["4-((3,5,5,8,8-pentamethyl--5,6,7,8-tetrahydro-2-naphthyl)carbonyl)benzoic acid O-methyloxime","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","10052980",1999,"Synthesis of retinoid X receptor-specific ligands that are potent inducers of adipogenesis in 3T3-L1 cells.","10052980","4-((3,5,5,8,8-pentamethyl--5,6,7,8-tetrahydro-2-naphthyl)carbonyl)benzoic acid O-methyloxime","Receptors, Retinoic Acid"]
["4-((3,5,5,8,8-pentamethyl--5,6,7,8-tetrahydro-2-naphthyl)carbonyl)benzoic acid O-methyloxime","Retinoid X Receptors_ag","Retinoid X Receptors","ag","10052980",1999,"Synthesis of retinoid X receptor-specific ligands that are potent inducers of adipogenesis in 3T3-L1 cells.","10052980","4-((3,5,5,8,8-pentamethyl--5,6,7,8-tetrahydro-2-naphthyl)carbonyl)benzoic acid O-methyloxime","Retinoid X Receptors"]
["4-((3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)carbonyl)benzoic acid oxime","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","10052980",1999,"Synthesis of retinoid X receptor-specific ligands that are potent inducers of adipogenesis in 3T3-L1 cells.","10052980","4-((3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)carbonyl)benzoic acid oxime","Receptors, Retinoic Acid"]
["4-((3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)carbonyl)benzoic acid oxime","Retinoid X Receptors_ag","Retinoid X Receptors","ag","10052980",1999,"Synthesis of retinoid X receptor-specific ligands that are potent inducers of adipogenesis in 3T3-L1 cells.","10052980","4-((3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)carbonyl)benzoic acid oxime","Retinoid X Receptors"]
["4-((4-(4-ethylphenyl)-2,2-dimethyl-(2H)-thiochromen-6-yl)ethynyl)benzoic acid","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","10465407",1999,"Synthesis and biological activity of high-affinity retinoic acid receptor antagonists.","10465407","4-((4-(4-ethylphenyl)-2,2-dimethyl-(2H)-thiochromen-6-yl)ethynyl)benzoic acid","Receptors, Retinoic Acid"]
["4-((4-(4-ethylphenyl)-2,2-dimethyl-(2H)-thiochromen-6-yl)ethynyl)benzoic acid","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","11487280",2001,"Antagonists of retinoic acid receptors (RARs) are potent growth inhibitors of prostate carcinoma cells.","11487280","4-((4-(4-ethylphenyl)-2,2-dimethyl-(2H)-thiochromen-6-yl)ethynyl)benzoic acid","Receptors, Retinoic Acid"]
["4-((4-(4-ethylphenyl)-2,2-dimethyl-(2H)-thiochromen-6-yl)ethynyl)benzoic acid","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","15266311",2004,"An antagonist of retinoic acid receptors more effectively inhibits growth of human prostate cancer cells than normal prostate epithelium.","15266311","4-((4-(4-ethylphenyl)-2,2-dimethyl-(2H)-thiochromen-6-yl)ethynyl)benzoic acid","Receptors, Retinoic Acid"]
["4-((4-(4-ethylphenyl)-2,2-dimethyl-(2H)-thiochromen-6-yl)ethynyl)benzoic acid","Retinoid X Receptors_antag","Retinoid X Receptors","antag","10465407",1999,"Synthesis and biological activity of high-affinity retinoic acid receptor antagonists.","10465407","4-((4-(4-ethylphenyl)-2,2-dimethyl-(2H)-thiochromen-6-yl)ethynyl)benzoic acid","Retinoid X Receptors"]
["4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","10672865",2000,"RAR gamma agonists inhibit proliferation of vascular smooth muscle cells.","10672865","4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid","Receptors, Retinoic Acid"]
["4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","10800078",2000,"Retinoid-dependent growth inhibition, differentiation and apoptosis in acute promyelocytic leukemia cells. Expression and activation of caspases.","10800078","4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid","Receptors, Retinoic Acid"]
["4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","11483254",2001,"Retinoic acid receptors are expressed in human primary astrocytes and their agonists inhibit parathyroid hormone-related peptide expression and secretion.","11483254","4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid","Receptors, Retinoic Acid"]
["4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","23441952",2013,"Differential effects of retinoids and inhibitors of ERK and p38 signaling on adipogenic and myogenic differentiation of P19 stem cells.","23441952","4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid","Receptors, Retinoic Acid"]
["4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","7636843",1995,"Synthesis and structure-activity relationships of stilbene retinoid analogs substituted with heteroaromatic carboxylic acids.","7636843","4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid","Receptors, Retinoic Acid"]
["4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","9262312",1997,"Receptor specificity of retinoid-induced epidermal hyperplasia: effect of RXR-selective agonists and correlation with topical irritation.","9262312","4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid","Receptors, Retinoic Acid"]
["4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","10423167",1999,"Inhibition of apolipoprotein(a) synthesis in cynomolgus monkey hepatocytes by retinoids via involvement of the retinoic acid receptor.","10423167","4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid","Receptors, Retinoic Acid"]
["4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","10465407",1999,"Synthesis and biological activity of high-affinity retinoic acid receptor antagonists.","10465407","4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid","Receptors, Retinoic Acid"]
["4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","10800078",2000,"Retinoid-dependent growth inhibition, differentiation and apoptosis in acute promyelocytic leukemia cells. Expression and activation of caspases.","10800078","4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid","Receptors, Retinoic Acid"]
["4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","11487280",2001,"Antagonists of retinoic acid receptors (RARs) are potent growth inhibitors of prostate carcinoma cells.","11487280","4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid","Receptors, Retinoic Acid"]
["4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","16091010",2005,"Upregulation of connexin 43 by retinoids but not by non-provitamin A carotenoids requires RARs.","16091010","4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid","Receptors, Retinoic Acid"]
["4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","23441952",2013,"Differential effects of retinoids and inhibitors of ERK and p38 signaling on adipogenic and myogenic differentiation of P19 stem cells.","23441952","4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid","Receptors, Retinoic Acid"]
["4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","8658506",1996,"Specific antagonist of retinoid toxicity in mice.","8658506","4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid","Receptors, Retinoic Acid"]
["4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","7636843",1995,"Synthesis and structure-activity relationships of stilbene retinoid analogs substituted with heteroaromatic carboxylic acids.","7636843","4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid","retinoic acid receptor alpha"]
["4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid","retinoic acid receptor gamma_ag","retinoic acid receptor gamma","ag","10672865",2000,"RAR gamma agonists inhibit proliferation of vascular smooth muscle cells.","10672865","4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid","retinoic acid receptor gamma"]
["4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid",{"$f":"C131&\"_\"&D131","v":"Retinoid X Receptors_ag"},"Retinoid X Receptors","ag","10800078",2000,"Retinoid-dependent growth inhibition, differentiation and apoptosis in acute promyelocytic leukemia cells. Expression and activation of caspases.","10800078","4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid","Retinoid X Receptors"]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  I132,I132)","v":"4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid"},"Retinoid X Receptors_ag",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  J132,J132)","v":"Retinoid X Receptors"},"ag",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & H132,H132)","v":"23441952"},2013,"Differential effects of retinoids and inhibitors of ERK and p38 signaling on adipogenic and myogenic differentiation of P19 stem cells.","23441952","4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid","Retinoid X Receptors"]
["4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid","Retinoid X Receptors_ag","Retinoid X Receptors","ag","7636843",1995,"Synthesis and structure-activity relationships of stilbene retinoid analogs substituted with heteroaromatic carboxylic acids.","7636843","4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid","Retinoid X Receptors"]
["4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid","Retinoid X Receptors_ag","Retinoid X Receptors","ag","9262312",1997,"Receptor specificity of retinoid-induced epidermal hyperplasia: effect of RXR-selective agonists and correlation with topical irritation.","9262312","4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid","Retinoid X Receptors"]
["4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid","Retinoid X Receptors_antag","Retinoid X Receptors","antag","10423167",1999,"Inhibition of apolipoprotein(a) synthesis in cynomolgus monkey hepatocytes by retinoids via involvement of the retinoic acid receptor.","10423167","4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid","Retinoid X Receptors"]
["4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid","Retinoid X Receptors_antag","Retinoid X Receptors","antag","10465407",1999,"Synthesis and biological activity of high-affinity retinoic acid receptor antagonists.","10465407","4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid","Retinoid X Receptors"]
["4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid","Retinoid X Receptors_antag","Retinoid X Receptors","antag","10800078",2000,"Retinoid-dependent growth inhibition, differentiation and apoptosis in acute promyelocytic leukemia cells. Expression and activation of caspases.","10800078","4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid","Retinoid X Receptors"]
["4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid","Retinoid X Receptors_antag","Retinoid X Receptors","antag","23441952",2013,"Differential effects of retinoids and inhibitors of ERK and p38 signaling on adipogenic and myogenic differentiation of P19 stem cells.","23441952","4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid","Retinoid X Receptors"]
["4-(2-(5,6-dihydro-5,5-dimethyl-8-(2-phenylethynyl)naphthalen-2-yl)ethen-1-yl)benzoic acid","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","19477412",2009,"Differential action on coregulator interaction defines inverse retinoid agonists and neutral antagonists.","19477412","4-(2-(5,6-dihydro-5,5-dimethyl-8-(2-phenylethynyl)naphthalen-2-yl)ethen-1-yl)benzoic acid","Receptors, Retinoic Acid"]
["4-(2-(5,6-dihydro-5,5-dimethyl-8-(2-phenylethynyl)naphthalen-2-yl)ethen-1-yl)benzoic acid","Retinoid X Receptor alpha_antag","Retinoid X Receptor alpha","antag","19477412",2009,"Differential action on coregulator interaction defines inverse retinoid agonists and neutral antagonists.","19477412","4-(2-(5,6-dihydro-5,5-dimethyl-8-(2-phenylethynyl)naphthalen-2-yl)ethen-1-yl)benzoic acid","Retinoid X Receptor alpha"]
["4-(3-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)phenyl)benzoic acid","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","10890153",2000,"4-[3-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)phenyl]benzoic acid and heterocyclic-bridged analogues are novel retinoic acid receptor subtype and retinoid X receptor alpha agonists.","10890153","4-(3-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)phenyl)benzoic acid","Receptors, Retinoic Acid"]
["4-(3-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)phenyl)benzoic acid","Retinoid X Receptors_ag","Retinoid X Receptors","ag","10890153",2000,"4-[3-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)phenyl]benzoic acid and heterocyclic-bridged analogues are novel retinoic acid receptor subtype and retinoid X receptor alpha agonists.","10890153","4-(3-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)phenyl)benzoic acid","Retinoid X Receptors"]
["4-(4-(2-(n-butoxy)ethoxy)-5-methylthiazol-2-yl)-2-fluorobenzoic acid","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","16302793",2005,"Discovery of a potent, orally available, and isoform-selective retinoic acid beta2 receptor agonist.","16302793","4-(4-(2-(n-butoxy)ethoxy)-5-methylthiazol-2-yl)-2-fluorobenzoic acid","Receptors, Retinoic Acid"]
["4-(4-(2-(n-butoxy)ethoxy)-5-methylthiazol-2-yl)-2-fluorobenzoic acid","retinoic acid receptor beta_ag","retinoic acid receptor beta","ag","16302793",2005,"Discovery of a potent, orally available, and isoform-selective retinoic acid beta2 receptor agonist.","16302793","4-(4-(2-(n-butoxy)ethoxy)-5-methylthiazol-2-yl)-2-fluorobenzoic acid","retinoic acid receptor beta"]
["4-(4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-quinoxalinyl)-1,3-thiazol-2-yl)benzoic acid","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","17076708",2006,"Marked improvement induced in photoaged skin of hairless mouse by ER36009, a novel RARgamma-specific retinoid, but not by ER35794, an RXR-selective agonist.","17076708","4-(4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-quinoxalinyl)-1,3-thiazol-2-yl)benzoic acid","Receptors, Retinoic Acid"]
["4-(4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-quinoxalinyl)-1,3-thiazol-2-yl)benzoic acid","retinoic acid receptor gamma_ag","retinoic acid receptor gamma","ag","17076708",2006,"Marked improvement induced in photoaged skin of hairless mouse by ER36009, a novel RARgamma-specific retinoid, but not by ER35794, an RXR-selective agonist.","17076708","4-(4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-quinoxalinyl)-1,3-thiazol-2-yl)benzoic acid","retinoic acid receptor gamma"]
["4-(4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-quinoxalinyl)-1,3-thiazol-2-yl)benzoic acid","Retinoid X Receptors_ag","Retinoid X Receptors","ag","17076708",2006,"Marked improvement induced in photoaged skin of hairless mouse by ER36009, a novel RARgamma-specific retinoid, but not by ER35794, an RXR-selective agonist.","17076708","4-(4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-quinoxalinyl)-1,3-thiazol-2-yl)benzoic acid","Retinoid X Receptors"]
["4-(4,5,7,8,9,10-hexahydro-7,7,10,10-tetramethyl-1-(3-pyridylmethyl)anthra-(1,2-b)pyrrol-3-yl)benzoic acid","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","11243576",2001,"Existence of retinoic acid-receptor-independent retinoid X-receptor-dependent pathway in myeloid cell function.","11243576","4-(4,5,7,8,9,10-hexahydro-7,7,10,10-tetramethyl-1-(3-pyridylmethyl)anthra-(1,2-b)pyrrol-3-yl)benzoic acid","Receptors, Retinoic Acid"]
["4-(4,5,7,8,9,10-hexahydro-7,7,10,10-tetramethyl-1-(3-pyridylmethyl)anthra-(1,2-b)pyrrol-3-yl)benzoic acid","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","11243576",2001,"Existence of retinoic acid-receptor-independent retinoid X-receptor-dependent pathway in myeloid cell function.","11243576","4-(4,5,7,8,9,10-hexahydro-7,7,10,10-tetramethyl-1-(3-pyridylmethyl)anthra-(1,2-b)pyrrol-3-yl)benzoic acid","Receptors, Retinoic Acid"]
["4-(4,5,7,8,9,10-hexahydro-7,7,10,10-tetramethyl-1-(3-pyridylmethyl)anthra-(1,2-b)pyrrol-3-yl)benzoic acid","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","9678718",1998,"A novel retinoic acid receptor (RAR)-selective antagonist inhibits differentiation and apoptosis of HL-60 cells: implications of RARalpha-mediated signals in myeloid leukemic cells.","9678718","4-(4,5,7,8,9,10-hexahydro-7,7,10,10-tetramethyl-1-(3-pyridylmethyl)anthra-(1,2-b)pyrrol-3-yl)benzoic acid","Receptors, Retinoic Acid"]
["4-(4,5,7,8,9,10-hexahydro-7,7,10,10-tetramethyl-1-(3-pyridylmethyl)anthra-(1,2-b)pyrrol-3-yl)benzoic acid","retinoic acid receptor alpha_antag","retinoic acid receptor alpha","antag","9678718",1998,"A novel retinoic acid receptor (RAR)-selective antagonist inhibits differentiation and apoptosis of HL-60 cells: implications of RARalpha-mediated signals in myeloid leukemic cells.","9678718","4-(4,5,7,8,9,10-hexahydro-7,7,10,10-tetramethyl-1-(3-pyridylmethyl)anthra-(1,2-b)pyrrol-3-yl)benzoic acid","retinoic acid receptor alpha"]
["4-(4,5,7,8,9,10-hexahydro-7,7,10,10-tetramethyl-1-(3-pyridylmethyl)anthra-(1,2-b)pyrrol-3-yl)benzoic acid","Retinoid X Receptors_ag","Retinoid X Receptors","ag","11243576",2001,"Existence of retinoic acid-receptor-independent retinoid X-receptor-dependent pathway in myeloid cell function.","11243576","4-(4,5,7,8,9,10-hexahydro-7,7,10,10-tetramethyl-1-(3-pyridylmethyl)anthra-(1,2-b)pyrrol-3-yl)benzoic acid","Retinoid X Receptors"]
["4-(4,5,7,8,9,10-hexahydro-7,7,10,10-tetramethyl-1-(3-pyridylmethyl)anthra-(1,2-b)pyrrol-3-yl)benzoic acid","Retinoid X Receptors_antag","Retinoid X Receptors","antag","11243576",2001,"Existence of retinoic acid-receptor-independent retinoid X-receptor-dependent pathway in myeloid cell function.","11243576","4-(4,5,7,8,9,10-hexahydro-7,7,10,10-tetramethyl-1-(3-pyridylmethyl)anthra-(1,2-b)pyrrol-3-yl)benzoic acid","Retinoid X Receptors"]
["4-(5-(7-fluoro-4-(trifluoromethyl)benzo(b)furan-2-yl)-1H-2-pyrrolyl)benzoic acid","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","15615868",2005,"Effect of E6060 [4-{5-[7-fluoro-4-(trifluoromethyl)benzo[b]furan-2-yl]-1H-2-pyrrolyl}benzoic acid], a novel subtype-selective retinoid, on lupus-like nephritis in female (NZBxNZW)F1 mice.","15615868","4-(5-(7-fluoro-4-(trifluoromethyl)benzo(b)furan-2-yl)-1H-2-pyrrolyl)benzoic acid","Receptors, Retinoic Acid"]
["4-(5-(7-fluoro-4-(trifluoromethyl)benzo(b)furan-2-yl)-1H-2-pyrrolyl)benzoic acid","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","15615868",2005,"Effect of E6060 [4-{5-[7-fluoro-4-(trifluoromethyl)benzo[b]furan-2-yl]-1H-2-pyrrolyl}benzoic acid], a novel subtype-selective retinoid, on lupus-like nephritis in female (NZBxNZW)F1 mice.","15615868","4-(5-(7-fluoro-4-(trifluoromethyl)benzo(b)furan-2-yl)-1H-2-pyrrolyl)benzoic acid","retinoic acid receptor alpha"]
["4-(5,6-dihydro-5,5-dimethyl-8-(quinolin-3-yl)naphthalen-2-carboxamido)benzoic acid","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","19477412",2009,"Differential action on coregulator interaction defines inverse retinoid agonists and neutral antagonists.","19477412","4-(5,6-dihydro-5,5-dimethyl-8-(quinolin-3-yl)naphthalen-2-carboxamido)benzoic acid","Receptors, Retinoic Acid"]
["4-(5,6-dihydro-5,5-dimethyl-8-(quinolin-3-yl)naphthalen-2-carboxamido)benzoic acid","Retinoid X Receptor alpha_antag","Retinoid X Receptor alpha","antag","19477412",2009,"Differential action on coregulator interaction defines inverse retinoid agonists and neutral antagonists.","19477412","4-(5,6-dihydro-5,5-dimethyl-8-(quinolin-3-yl)naphthalen-2-carboxamido)benzoic acid","Retinoid X Receptor alpha"]
["4-dimethylaminoazobenzene-4'-iodoacetamide","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","15606778",2004,"Brain succinic semialdehyde dehydrogenase. Reactions of sulfhydryl residues connected with catalytic activity.","15606778","4-dimethylaminoazobenzene-4'-iodoacetamide","Aldehyde Oxidoreductases"]
["4-hydroxy-2-nonenal","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","12527414",2003,"Inhibition of succinic semialdehyde dehydrogenase activity by alkenal products of lipid peroxidation.","12527414","4-hydroxy-2-nonenal","Aldehyde Oxidoreductases"]
["4-hydroxyretinoic acid","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","11212271",2001,"Granulocytic differentiation of human NB4 promyelocytic leukemia cells induced by all-trans retinoic acid metabolites.","11212271","4-hydroxyretinoic acid","Receptors, Retinoic Acid"]
["4-hydroxyretinoic acid","retinoic acid receptor alpha_antag","retinoic acid receptor alpha","antag","11212271",2001,"Granulocytic differentiation of human NB4 promyelocytic leukemia cells induced by all-trans retinoic acid metabolites.","11212271","4-hydroxyretinoic acid","retinoic acid receptor alpha"]
["4-methoxyestradiol","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","12810639",2003,"Methoxyestrogens exert feedback inhibition on cytochrome P450 1A1 and 1B1.","12810639","4-methoxyestradiol","Cytochrome P-450 CYP1A1"]
["4-nonylphenol","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","16219370",2005,"Effects of 17beta-estradiol, 4-nonylphenol and PCB 126 on the estrogenic activity and phase 1 and 2 biotransformation enzymes in male sea bass (Dicentrarchus labrax).","16219370","4-nonylphenol","Cytochrome P-450 CYP1A1"]
["4'-octyl-4-biphenylcarboxylic acid","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","16302793",2005,"Discovery of a potent, orally available, and isoform-selective retinoic acid beta2 receptor agonist.","16302793","4'-octyl-4-biphenylcarboxylic acid","Receptors, Retinoic Acid"]
["4'-octyl-4-biphenylcarboxylic acid","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","23703360",2013,"Chemical activation of RARβ induces post-embryonically bilateral limb duplication during Xenopus limb regeneration.","23703360","4'-octyl-4-biphenylcarboxylic acid","Receptors, Retinoic Acid"]
["4'-octyl-4-biphenylcarboxylic acid","retinoic acid 4-hydroxylase_antag","retinoic acid 4-hydroxylase","antag","23703360",2013,"Chemical activation of RARβ induces post-embryonically bilateral limb duplication during Xenopus limb regeneration.","23703360","4'-octyl-4-biphenylcarboxylic acid","retinoic acid 4-hydroxylase"]
["4'-octyl-4-biphenylcarboxylic acid","retinoic acid receptor beta_ag","retinoic acid receptor beta","ag","16302793",2005,"Discovery of a potent, orally available, and isoform-selective retinoic acid beta2 receptor agonist.","16302793","4'-octyl-4-biphenylcarboxylic acid","retinoic acid receptor beta"]
["4-oxoretinoic acid","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","23077743",2012,"Detection of retinoic acid receptor agonistic activity and identification of causative compounds in municipal wastewater treatment plants in Japan.","23077743","4-oxoretinoic acid","Receptors, Retinoic Acid"]
["4-oxoretinoic acid","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","11212271",2001,"Granulocytic differentiation of human NB4 promyelocytic leukemia cells induced by all-trans retinoic acid metabolites.","11212271","4-oxoretinoic acid","Receptors, Retinoic Acid"]
["4-oxoretinoic acid","retinoic acid receptor alpha_antag","retinoic acid receptor alpha","antag","11212271",2001,"Granulocytic differentiation of human NB4 promyelocytic leukemia cells induced by all-trans retinoic acid metabolites.","11212271","4-oxoretinoic acid","retinoic acid receptor alpha"]
["4-oxoretinol","retinol dehydratase_antag","retinol dehydratase","antag","15608121",2005,"The structures of the unique sulfotransferase retinol dehydratase with product and inhibitors provide insight into enzyme mechanism and inhibition.","15608121","4-oxoretinol","retinol dehydratase"]
["5-(4-ethylpiperazin-1-ylmethyl)pyridin-2-yl)-(5-fluoro-4-(7-fluoro-3-isopropyl-2-methyl-3H-benzoimidazol-5-yl)pyrimidin-2-yl)amine","Retinoblastoma Protein_antag","Retinoblastoma Protein","antag","24919854",2014,"Preclinical characterization of the CDK4/6 inhibitor LY2835219: in-vivo cell cycle-dependent/independent anti-tumor activities alone/in combination with gemcitabine.","24919854","5-(4-ethylpiperazin-1-ylmethyl)pyridin-2-yl)-(5-fluoro-4-(7-fluoro-3-isopropyl-2-methyl-3H-benzoimidazol-5-yl)pyrimidin-2-yl)amine","Retinoblastoma Protein"]
["5,6-epoxyretinoic acid","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","11212271",2001,"Granulocytic differentiation of human NB4 promyelocytic leukemia cells induced by all-trans retinoic acid metabolites.","11212271","5,6-epoxyretinoic acid","Receptors, Retinoic Acid"]
["5,6-epoxyretinoic acid","retinoic acid receptor alpha_antag","retinoic acid receptor alpha","antag","11212271",2001,"Granulocytic differentiation of human NB4 promyelocytic leukemia cells induced by all-trans retinoic acid metabolites.","11212271","5,6-epoxyretinoic acid","retinoic acid receptor alpha"]
["5,7-dimethoxyflavone","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","16484233",2006,"Inhibition of benzo[a]pyrene-activating enzymes and DNA binding in human bronchial epithelial BEAS-2B cells by methoxylated flavonoids.","16484233","5,7-dimethoxyflavone","Cytochrome P-450 CYP1A1"]
["5-androstene-16-fluoro-17-one","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","12097275",2002,"Inhibition of carcinogen-activating enzymes by 16alpha-fluoro-5-androsten-17-one.","12097275","5-androstene-16-fluoro-17-one","Cytochrome P-450 CYP1A1"]
["5-ethynyl-2(1H)-pyrimidinone","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","8161345",1994,"5-ethynyl-2(1H)-pyrimidinone: aldehyde oxidase-activation to 5-ethynyluracil, a mechanism-based inactivator of dihydropyrimidine dehydrogenase.","8161345","5-ethynyl-2(1H)-pyrimidinone","Aldehyde Oxidoreductases"]
["5'PPP-RNA","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","23633948",2013,"Systems analysis of a RIG-I agonist inducing broad spectrum inhibition of virus infectivity.","23633948","5'PPP-RNA","Receptors, Retinoic Acid"]
["6,12-diformylindolo(3,2-b)carbazole","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","9566724",1998,"Rapid and transient induction of CYP1A1 gene expression in human cells by the tryptophan photoproduct 6-formylindolo[3,2-b]carbazole.","9566724","6,12-diformylindolo(3,2-b)carbazole","Cytochrome P-450 CYP1A1"]
["6-formylindolo(3,2-b)carbazole","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","9566724",1998,"Rapid and transient induction of CYP1A1 gene expression in human cells by the tryptophan photoproduct 6-formylindolo[3,2-b]carbazole.","9566724","6-formylindolo(3,2-b)carbazole","Cytochrome P-450 CYP1A1"]
["6-methyl-1,3,8-trichlorodibenzofuran","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","15535986",2004,"Lack of antagonism of 2,3,7,8-tetrachlorodibenzo-p-dioxin's (TCDDs) induction of cytochrome P4501A1 (CYP1A1) by the putative selective aryl hydrocarbon receptor modulator 6-alkyl-1,3,8-trichlorodibenzofuran (6-MCDF) in the mouse hepatoma cell line Hepa-1c1c7.","15535986","6-methyl-1,3,8-trichlorodibenzofuran","Cytochrome P-450 CYP1A1"]
["6-OH-11-O-hydroxyphenanthrene","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","22261616",2012,"Nuclear receptors agonists exert opposing effects on the inflammation dependent survival of breast cancer stem cells.","22261616","6-OH-11-O-hydroxyphenanthrene","Receptors, Retinoic Acid"]
["6-OH-11-O-hydroxyphenanthrene","Retinoid X Receptors_ag","Retinoid X Receptors","ag","22261616",2012,"Nuclear receptors agonists exert opposing effects on the inflammation dependent survival of breast cancer stem cells.","22261616","6-OH-11-O-hydroxyphenanthrene","Retinoid X Receptors"]
["6-tert-butyl-1,1-dimethylindanyl","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","12182871",2002,"Synthesis and characterization of a new RXR agonist based on the 6-tert-butyl-1,1-dimethylindanyl structure.","12182871","6-tert-butyl-1,1-dimethylindanyl","Receptors, Retinoic Acid"]
["6-tert-butyl-1,1-dimethylindanyl","Retinoid X Receptors_ag","Retinoid X Receptors","ag","12182871",2002,"Synthesis and characterization of a new RXR agonist based on the 6-tert-butyl-1,1-dimethylindanyl structure.","12182871","6-tert-butyl-1,1-dimethylindanyl","Retinoid X Receptors"]
["7-(1-(1-methylethyl)-1,2,3,4-tetrahydroquinolin-6-yl)-6-fluoro-3-methylnona-2,4,6-trienoic acid","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","17076708",2006,"Marked improvement induced in photoaged skin of hairless mouse by ER36009, a novel RARgamma-specific retinoid, but not by ER35794, an RXR-selective agonist.","17076708","7-(1-(1-methylethyl)-1,2,3,4-tetrahydroquinolin-6-yl)-6-fluoro-3-methylnona-2,4,6-trienoic acid","Receptors, Retinoic Acid"]
["7-(1-(1-methylethyl)-1,2,3,4-tetrahydroquinolin-6-yl)-6-fluoro-3-methylnona-2,4,6-trienoic acid","retinoic acid receptor gamma_ag","retinoic acid receptor gamma","ag","17076708",2006,"Marked improvement induced in photoaged skin of hairless mouse by ER36009, a novel RARgamma-specific retinoid, but not by ER35794, an RXR-selective agonist.","17076708","7-(1-(1-methylethyl)-1,2,3,4-tetrahydroquinolin-6-yl)-6-fluoro-3-methylnona-2,4,6-trienoic acid","retinoic acid receptor gamma"]
["7-(1-(1-methylethyl)-1,2,3,4-tetrahydroquinolin-6-yl)-6-fluoro-3-methylnona-2,4,6-trienoic acid","Retinoid X Receptors_ag","Retinoid X Receptors","ag","17076708",2006,"Marked improvement induced in photoaged skin of hairless mouse by ER36009, a novel RARgamma-specific retinoid, but not by ER35794, an RXR-selective agonist.","17076708","7-(1-(1-methylethyl)-1,2,3,4-tetrahydroquinolin-6-yl)-6-fluoro-3-methylnona-2,4,6-trienoic acid","Retinoid X Receptors"]
["7-(1-(1-methylethyl)-8-chloro-1,2,3,4-tetrahydroquinolin-6-yl)-6-fluoro-3-methyl-2,4,6-nonatrienoic acid","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","11243576",2001,"Existence of retinoic acid-receptor-independent retinoid X-receptor-dependent pathway in myeloid cell function.","11243576","7-(1-(1-methylethyl)-8-chloro-1,2,3,4-tetrahydroquinolin-6-yl)-6-fluoro-3-methyl-2,4,6-nonatrienoic acid","Receptors, Retinoic Acid"]
["7-(1-(1-methylethyl)-8-chloro-1,2,3,4-tetrahydroquinolin-6-yl)-6-fluoro-3-methyl-2,4,6-nonatrienoic acid","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","11243576",2001,"Existence of retinoic acid-receptor-independent retinoid X-receptor-dependent pathway in myeloid cell function.","11243576","7-(1-(1-methylethyl)-8-chloro-1,2,3,4-tetrahydroquinolin-6-yl)-6-fluoro-3-methyl-2,4,6-nonatrienoic acid","Receptors, Retinoic Acid"]
["7-(1-(1-methylethyl)-8-chloro-1,2,3,4-tetrahydroquinolin-6-yl)-6-fluoro-3-methyl-2,4,6-nonatrienoic acid","Retinoid X Receptors_ag","Retinoid X Receptors","ag","11243576",2001,"Existence of retinoic acid-receptor-independent retinoid X-receptor-dependent pathway in myeloid cell function.","11243576","7-(1-(1-methylethyl)-8-chloro-1,2,3,4-tetrahydroquinolin-6-yl)-6-fluoro-3-methyl-2,4,6-nonatrienoic acid","Retinoid X Receptors"]
["7-(1-(1-methylethyl)-8-chloro-1,2,3,4-tetrahydroquinolin-6-yl)-6-fluoro-3-methyl-2,4,6-nonatrienoic acid","Retinoid X Receptors_antag","Retinoid X Receptors","antag","11243576",2001,"Existence of retinoic acid-receptor-independent retinoid X-receptor-dependent pathway in myeloid cell function.","11243576","7-(1-(1-methylethyl)-8-chloro-1,2,3,4-tetrahydroquinolin-6-yl)-6-fluoro-3-methyl-2,4,6-nonatrienoic acid","Retinoid X Receptors"]
["7-(2-(2,2-difluoroethoxy)-3,5-di-tert-butylbenzene)-3-methylocta-2,4,6-trienoic acid","Retinoid X Receptors_ag","Retinoid X Receptors","ag","16269450",2006,"Biological characterization of a heterodimer-selective retinoid X receptor modulator: potential benefits for the treatment of type 2 diabetes.","16269450","7-(2-(2,2-difluoroethoxy)-3,5-di-tert-butylbenzene)-3-methylocta-2,4,6-trienoic acid","Retinoid X Receptors"]
["7,12-dimethylbenz(a)anthracene-dihydrodiol","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","10558919",1999,"The role of polycyclic aromatic hydrocarbon metabolism in dimethylbenz[a]anthracene-induced pre-B lymphocyte apoptosis.","10558919","7,12-dimethylbenz(a)anthracene-dihydrodiol","Cytochrome P-450 CYP1A1"]
["7,12-dimethylbenz(a)anthracene-DNA adduct",{"$f":"C195&\"_\"&D195","v":"Cytochrome P-450 CYP1A1_antag"},"Cytochrome P-450 CYP1A1","antag","25697376",2015,"Metformin inhibits 7,12-dimethylbenz[a]anthracene-induced breast carcinogenesis and adduct formation in human breast cells by inhibiting the cytochrome P4501A1/aryl hydrocarbon receptor signaling pathway.","25697376","7,12-dimethylbenz(a)anthracene-DNA adduct","Cytochrome P-450 CYP1A1"]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  I196,I196)","v":"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"},"Receptors, Retinoic Acid_antag",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  J196,J196)","v":"Receptors, Retinoic Acid"},"antag",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & H196,H196)","v":"16170369"},2005,"Induction of cyclooxygenase-2 by benzo[a]pyrene diol epoxide through inhibition of retinoic acid receptor-beta 2 expression.","16170369","7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide","Receptors, Retinoic Acid"]
["7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide","retinoic acid receptor beta_antag","retinoic acid receptor beta","antag","16170369",2005,"Induction of cyclooxygenase-2 by benzo[a]pyrene diol epoxide through inhibition of retinoic acid receptor-beta 2 expression.","16170369","7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide","retinoic acid receptor beta"]
["7-ethynylcoumarin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","22443586",2012,"7-Ethynylcoumarins: selective inhibitors of human cytochrome P450s 1A1 and 1A2.","22443586","7-ethynylcoumarin","Cytochrome P-450 CYP1A1"]
["7-hydroxyretinoic acid","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","21145941",2011,"A novel retinoic acid analogue, 7-hydroxy retinoic acid, isolated from cyanobacteria.","21145941","7-hydroxyretinoic acid","Receptors, Retinoic Acid"]
["8-prenylnaringenin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","10752639",2000,"In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops, Humulus lupulus.","10752639","8-prenylnaringenin","Cytochrome P-450 CYP1A1"]
["9-(3-hydroxypropoxy)guanine","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","8013273",1994,"Use of rat and human in vitro systems to assess the effectiveness and enzymology of deoxyguanine analogs as prodrugs of an antiviral agent.","8013273","9-(3-hydroxypropoxy)guanine","Aldehyde Oxidoreductases"]
["9,10-Dimethyl-1,2-benzanthracene","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","10558919",1999,"The role of polycyclic aromatic hydrocarbon metabolism in dimethylbenz[a]anthracene-induced pre-B lymphocyte apoptosis.","10558919","9,10-Dimethyl-1,2-benzanthracene","Cytochrome P-450 CYP1A1"]
["9,10-Dimethyl-1,2-benzanthracene","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","11006352",2000,"Influence of beta-naphthoflavone on 7,12-dimethylbenz(a)anthracene metabolism, DNA adduction, and tumorigenicity in rainbow trout.","11006352","9,10-Dimethyl-1,2-benzanthracene","Cytochrome P-450 CYP1A1"]
["9,10-Dimethyl-1,2-benzanthracene","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","11159744",2001,"Oral administration of naturally occurring coumarins leads to altered phase I and II enzyme activities and reduced DNA adduct formation by polycyclic aromatic hydrocarbons in various tissues of SENCAR mice.","11159744","9,10-Dimethyl-1,2-benzanthracene","Cytochrome P-450 CYP1A1"]
["9,10-Dimethyl-1,2-benzanthracene","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","18255114",2008,"Chemopreventive effects of Furan-2-yl-3-pyridin-2-yl-propenone against 7,12-dimethylbenz[a]anthracene-inducible genotoxicity.","18255114","9,10-Dimethyl-1,2-benzanthracene","Cytochrome P-450 CYP1A1"]
["9,10-Dimethyl-1,2-benzanthracene","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","25697376",2015,"Metformin inhibits 7,12-dimethylbenz[a]anthracene-induced breast carcinogenesis and adduct formation in human breast cells by inhibiting the cytochrome P4501A1/aryl hydrocarbon receptor signaling pathway.","25697376","9,10-Dimethyl-1,2-benzanthracene","Cytochrome P-450 CYP1A1"]
["9,13-retinoic acid","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","9247151",1997,"9,13-di-cis-Retinoic acid induces the production of tPA and activation of latent TGF-beta via RAR alpha in a human liver stellate cell line, LI90.","9247151","9,13-retinoic acid","Receptors, Retinoic Acid"]
["9,13-retinoic acid","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","9247151",1997,"9,13-di-cis-Retinoic acid induces the production of tPA and activation of latent TGF-beta via RAR alpha in a human liver stellate cell line, LI90.","9247151","9,13-retinoic acid","Receptors, Retinoic Acid"]
["9,13-retinoic acid","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","9247151",1997,"9,13-di-cis-Retinoic acid induces the production of tPA and activation of latent TGF-beta via RAR alpha in a human liver stellate cell line, LI90.","9247151","9,13-retinoic acid","retinoic acid receptor alpha"]
["9,13-retinoic acid","retinoic acid receptor alpha_antag","retinoic acid receptor alpha","antag","9247151",1997,"9,13-di-cis-Retinoic acid induces the production of tPA and activation of latent TGF-beta via RAR alpha in a human liver stellate cell line, LI90.","9247151","9,13-retinoic acid","retinoic acid receptor alpha"]
["9-hydroxybenzo(a)pyrene","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","8896715",1996,"Pentachlorophenol enhances 9-hydroxybenzo [a] pyrene-induced hepatic DNA adduct formation in vivo and inhibits microsomal epoxide hydrolase and glutathione S-transferase activities in vitro: likely inhibition of epoxide detoxication by pentachlorophenol.","8896715","9-hydroxybenzo(a)pyrene","Cytochrome P-450 CYP1A1"]
["A1120 agent","Retinol-Binding Proteins, Plasma_ag","Retinol-Binding Proteins, Plasma","ag","19147488",2009,"Identification and characterization of a non-retinoid ligand for retinol-binding protein 4 which lowers serum retinol-binding protein 4 levels in vivo.","19147488","A1120 agent","Retinol-Binding Proteins, Plasma"]
["A1120 agent","Retinol-Binding Proteins, Plasma_antag","Retinol-Binding Proteins, Plasma","antag","23211825",2013,"A1120, a nonretinoid RBP4 antagonist, inhibits formation of cytotoxic bisretinoids in the animal model of enhanced retinal lipofuscinogenesis.","23211825","A1120 agent","Retinol-Binding Proteins, Plasma"]
["Acetaldehyde","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","12198016",2002,"Generation of protein adducts with malondialdehyde and acetaldehyde in muscles with predominantly type I or type II fibers in rats exposed to ethanol and the acetaldehyde dehydrogenase inhibitor cyanamide.","12198016","Acetaldehyde","Aldehyde Oxidoreductases"]
["Acetaldehyde","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","18003597",2008,"PPARalpha and PPARbeta are differentially affected by ethanol and the ethanol metabolite acetaldehyde in the MCF-7 breast cancer cell line.","18003597","Acetaldehyde","Aldehyde Oxidoreductases"]
["Acetaldehyde","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","20082270",2010,"DNA repair mutant pso2 of Saccharomyces cerevisiae is sensitive to intracellular acetaldehyde accumulated by disulfiram-mediated inhibition of acetaldehyde dehydrogenase.","20082270","Acetaldehyde","Aldehyde Oxidoreductases"]
["Acetaldehyde","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","4513686",1973,"Alcohol, aldehydes, and biogenic amines.","4513686","Acetaldehyde","Aldehyde Oxidoreductases"]
["Acetaldehyde","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","6701903",1984,"Subcellular aldehyde dehydrogenase activity and acetaldehyde oxidation by isolated intact mitochondria of rat brain and liver after acetaldehyde treatment.","6701903","Acetaldehyde","Aldehyde Oxidoreductases"]
["Acetaldehyde","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","6775515",1980,"Acetaldehyde hydrate and carbonic anhydrase: possible roles in the inhibition of brain aldehyde dehydrogenase.","6775515","Acetaldehyde","Aldehyde Oxidoreductases"]
["Acetaldehyde","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","7013545",1981,"The effect of cyanamide on acetaldehyde oxidation by isolated rat liver mitochondria and on the inhibition of pyruvate oxidation by acetaldehyde.","7013545","Acetaldehyde","Aldehyde Oxidoreductases"]
["Acetaldehyde","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","7163339",1982,"Reversible inhibitors of aldehyde dehydrogenase.","7163339","Acetaldehyde","Aldehyde Oxidoreductases"]
["Acetazolamide","Secretin_antag","Secretin","antag","5580342",1971,"Mode of action of acetazolamide on pancreatic exocrine secretion.","5580342","Acetazolamide","Secretin"]
["Acetazolamide","Secretin_antag","Secretin","antag","5659822",1968,"The effect of a carbonic anhydrase inhibitor, Diamox, on human pancreatic secretion. Implications on the mechanism of pancreatic secretion.","5659822","Acetazolamide","Secretin"]
["Acetylcholine","Secretin_antag","Secretin","antag","8910214",1996,"Interactions between secretin and acetylcholine in the regulation of fluid secretion by isolated rat pancreatic ducts.","8910214","Acetylcholine","Secretin"]
["Acetylene","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","1510726",1992,"Suicide inhibitors of cytochrome P450 1A1 and P450 2B1.","1510726","Acetylene","Cytochrome P-450 CYP1A1"]
["Acetylene","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","8448348",1993,"Determinants of protein modification versus heme alkylation: inactivation of cytochrome P450 1A1 by 1-ethynylpyrene and phenylacetylene.","8448348","Acetylene","Cytochrome P-450 CYP1A1"]
["Acetylene","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","9074808",1997,"Aryl acetylenes as mechanism-based inhibitors of cytochrome P450-dependent monooxygenase enzymes.","9074808","Acetylene","Cytochrome P-450 CYP1A1"]
["Acitretin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","20861754",2011,"The effect of retinoic acid receptor agonist acitretin on the production of bile and concentrations of some serum components in ovariectomized rats.","20861754","Acitretin","Receptors, Retinoic Acid"]
["Acitretin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","23891453",2013,"Guidelines for the use of acitretin in psoriasis. Psoriasis Group of the Spanish Academy of Dermatology and Venereology.","23891453","Acitretin","Receptors, Retinoic Acid"]
["Acitretin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","23925292",2013,"Retinoids activate the irritant receptor TRPV1 and produce sensory hypersensitivity.","23925292","Acitretin","Receptors, Retinoic Acid"]
["Acrolein","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","12527414",2003,"Inhibition of succinic semialdehyde dehydrogenase activity by alkenal products of lipid peroxidation.","12527414","Acrolein","Aldehyde Oxidoreductases"]
["Acrolein","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","3103627",1987,"Inhibition of microsomal cytochrome c reductase activity by a series of alpha, beta-unsaturated aldehydes.","3103627","Acrolein","Cytochrome P-450 CYP1A1"]
["Acrylamide","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","1358542",1992,"Effect of acrylamide monomer on hepatic CYP1A1 monooxygenase induction in rainbow trout.","1358542","Acrylamide","Cytochrome P-450 CYP1A1"]
["Adamantane","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","9365537",1997,"Induction of apoptosis in human non-small cell lung carcinoma cells by the novel synthetic retinoid CD437.","9365537","Adamantane","Receptors, Retinoic Acid"]
["Adamantane","Retinoid X Receptors_antag","Retinoid X Receptors","antag","19216008",2009,"Highly twisted adamantyl arotinoids: synthesis, antiproliferative effects and RXR transactivation profiles.","19216008","Adamantane","Retinoid X Receptors"]
["Adapalene","Retinoblastoma Protein_antag","Retinoblastoma Protein","antag","26398439",2015,"Adapalene inhibits the activity of cyclin-dependent kinase 2 in colorectal carcinoma.","26398439","Adapalene","Retinoblastoma Protein"]
["Adenine","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","24659340",2014,"Comparative study of autophagy inhibition by 3MA and CQ  on Cytarabine‑induced death of leukaemia cells.","24659340","Adenine","Receptors, Retinoic Acid"]
["Adenine","retinoic acid receptor alpha_antag","retinoic acid receptor alpha","antag","24659340",2014,"Comparative study of autophagy inhibition by 3MA and CQ  on Cytarabine‑induced death of leukaemia cells.","24659340","Adenine","retinoic acid receptor alpha"]
["afimoxifene","Retinoblastoma Protein_antag","Retinoblastoma Protein","antag","11032025",2000,"Reversal of an antiestrogen-mediated cell cycle arrest of MCF-7 cells by viral tumor antigens requires the retinoblastoma protein-binding domain.","11032025","afimoxifene","Retinoblastoma Protein"]
["Aflatoxin B1","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","10434373",1999,"Effects of aflatoxin B1 on the hepatic microsomal mixed function oxidase system during phenobarbital and benzo(a)pyrene treatment in chickens.","10434373","Aflatoxin B1","Cytochrome P-450 CYP1A1"]
["Aflatoxin B1","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","10906438",2000,"Cytochrome P450-mediated metabolism and cytotoxicity of aflatoxin B(1) in bovine hepatocytes.","10906438","Aflatoxin B1","Cytochrome P-450 CYP1A1"]
["Aflatoxin B1","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","18177683",2008,"Mechanisms of butylated hydroxytoluene chemoprevention of aflatoxicosis--inhibition of aflatoxin B1 metabolism.","18177683","Aflatoxin B1","Cytochrome P-450 CYP1A1"]
["aflatoxin B1-8,9-dihydrodiol-Tris buffer complex","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","10906438",2000,"Cytochrome P450-mediated metabolism and cytotoxicity of aflatoxin B(1) in bovine hepatocytes.","10906438","aflatoxin B1-8,9-dihydrodiol-Tris buffer complex","Cytochrome P-450 CYP1A1"]
["AGN 190121","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","9262312",1997,"Receptor specificity of retinoid-induced epidermal hyperplasia: effect of RXR-selective agonists and correlation with topical irritation.","9262312","AGN 190121","Receptors, Retinoic Acid"]
["AGN 190121","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","9694631",1998,"The use of a retinoid receptor antagonist in a new model to study vitamin A-dependent developmental events.","9694631","AGN 190121","Receptors, Retinoic Acid"]
["AGN 190121","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","8937896",1996,"Retinoid-induced epiphyseal plate closure in guinea pigs.","8937896","AGN 190121","Receptors, Retinoic Acid"]
["AGN 190121","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","9694631",1998,"The use of a retinoid receptor antagonist in a new model to study vitamin A-dependent developmental events.","9694631","AGN 190121","Receptors, Retinoic Acid"]
["AGN 190121","Retinoid X Receptors_ag","Retinoid X Receptors","ag","9262312",1997,"Receptor specificity of retinoid-induced epidermal hyperplasia: effect of RXR-selective agonists and correlation with topical irritation.","9262312","AGN 190121","Retinoid X Receptors"]
["AGN 191659","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","11728386",2001,"Retinoid X receptor agonist elevation of serum triglycerides in rats by potentiation of retinoic acid receptor agonist induction or by action as single agents.","11728386","AGN 191659","Receptors, Retinoic Acid"]
["AGN 191659","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","11728386",2001,"Retinoid X receptor agonist elevation of serum triglycerides in rats by potentiation of retinoic acid receptor agonist induction or by action as single agents.","11728386","AGN 191659","Receptors, Retinoic Acid"]
["AGN 191659","Retinoid X Receptors_ag","Retinoid X Receptors","ag","11728386",2001,"Retinoid X receptor agonist elevation of serum triglycerides in rats by potentiation of retinoic acid receptor agonist induction or by action as single agents.","11728386","AGN 191659","Retinoid X Receptors"]
["AGN 191659","Retinoid X Receptors_antag","Retinoid X Receptors","antag","11728386",2001,"Retinoid X receptor agonist elevation of serum triglycerides in rats by potentiation of retinoic acid receptor agonist induction or by action as single agents.","11728386","AGN 191659","Retinoid X Receptors"]
["AGN 191701","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","9313779",1997,"Mitogenic effect of retinoid X receptor agonists in rat liver.","9313779","AGN 191701","Receptors, Retinoic Acid"]
["AGN 191701","Retinoid X Receptors_ag","Retinoid X Receptors","ag","9313779",1997,"Mitogenic effect of retinoid X receptor agonists in rat liver.","9313779","AGN 191701","Retinoid X Receptors"]
["AGN 193109","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","9694631",1998,"The use of a retinoid receptor antagonist in a new model to study vitamin A-dependent developmental events.","9694631","AGN 193109","Receptors, Retinoic Acid"]
["AGN 193109","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","10098666",1999,"High affinity retinoic acid receptor antagonists: analogs of AGN 193109.","10098666","AGN 193109","Receptors, Retinoic Acid"]
["AGN 193109","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","11446831",2001,"The synthetic retinoid AGN 193109 but not retinoic acid elevates CYP1A1 levels in mouse embryos and Hepa-1c1c7 cells.","11446831","AGN 193109","Receptors, Retinoic Acid"]
["AGN 193109","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","7490725",1995,"Synthesis and characterization of a highly potent and effective antagonist of retinoic acid receptors.","7490725","AGN 193109","Receptors, Retinoic Acid"]
["AGN 193109",{"$f":"C259&\"_\"&D259","v":"Receptors, Retinoic Acid_antag"},"Receptors, Retinoic Acid","antag","8647816",1996,"AGN193109 is a highly effective antagonist of retinoid action in human ectocervical epithelial cells.","8647816","AGN 193109","Receptors, Retinoic Acid"]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  I260,I260)","v":"AGN 193109"},"Receptors, Retinoic Acid_antag",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  J260,J260)","v":"Receptors, Retinoic Acid"},"antag",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & H260,H260)","v":"8658506"},1996,"Specific antagonist of retinoid toxicity in mice.","8658506","AGN 193109","Receptors, Retinoic Acid"]
["AGN 193109","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","9694631",1998,"The use of a retinoid receptor antagonist in a new model to study vitamin A-dependent developmental events.","9694631","AGN 193109","Receptors, Retinoic Acid"]
["AGN 193835","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","8759622",1996,"Identification of a retinoic acid receptor alpha subtype specific agonist.","8759622","AGN 193835","Receptors, Retinoic Acid"]
["AGN 193835","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","8759622",1996,"Identification of a retinoic acid receptor alpha subtype specific agonist.","8759622","AGN 193835","retinoic acid receptor alpha"]
["AGN 193835","Retinoid X Receptors_ag","Retinoid X Receptors","ag","8759622",1996,"Identification of a retinoic acid receptor alpha subtype specific agonist.","8759622","AGN 193835","Retinoid X Receptors"]
["AGN 193836","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","8759622",1996,"Identification of a retinoic acid receptor alpha subtype specific agonist.","8759622","AGN 193836","Receptors, Retinoic Acid"]
["AGN 193836","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","10652597",1999,"Different effects of the treatment with AGN 193836 and 9-cis-retinoic acid in breast cancer cells.","10652597","AGN 193836","Receptors, Retinoic Acid"]
["AGN 193836","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","8759622",1996,"Identification of a retinoic acid receptor alpha subtype specific agonist.","8759622","AGN 193836","retinoic acid receptor alpha"]
["AGN 193836","Retinoid X Receptors_ag","Retinoid X Receptors","ag","8759622",1996,"Identification of a retinoic acid receptor alpha subtype specific agonist.","8759622","AGN 193836","Retinoid X Receptors"]
["AGN 194204","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","11428923",2001,"Enantioselective syntheses of potent retinoid X receptor ligands: differential biological activities of individual antipodes.","11428923","AGN 194204","Receptors, Retinoic Acid"]
["AGN 194204","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","14712350",2004,"Retinoic acid receptor alpha and retinoid X receptor specific agonists reduce renal injury in established chronic glomerulonephritis of the rat.","14712350","AGN 194204","Receptors, Retinoic Acid"]
["AGN 194204","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","14712350",2004,"Retinoic acid receptor alpha and retinoid X receptor specific agonists reduce renal injury in established chronic glomerulonephritis of the rat.","14712350","AGN 194204","retinoic acid receptor alpha"]
["AGN 194204","Retinoid X Receptors_ag","Retinoid X Receptors","ag","11428923",2001,"Enantioselective syntheses of potent retinoid X receptor ligands: differential biological activities of individual antipodes.","11428923","AGN 194204","Retinoid X Receptors"]
["AGN 194204","Retinoid X Receptors_ag","Retinoid X Receptors","ag","14712350",2004,"Retinoic acid receptor alpha and retinoid X receptor specific agonists reduce renal injury in established chronic glomerulonephritis of the rat.","14712350","AGN 194204","Retinoid X Receptors"]
["AGN 195183","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","14712350",2004,"Retinoic acid receptor alpha and retinoid X receptor specific agonists reduce renal injury in established chronic glomerulonephritis of the rat.","14712350","AGN 195183","Receptors, Retinoic Acid"]
["AGN 195183","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","14712350",2004,"Retinoic acid receptor alpha and retinoid X receptor specific agonists reduce renal injury in established chronic glomerulonephritis of the rat.","14712350","AGN 195183","retinoic acid receptor alpha"]
["AGN 195183","Retinoid X Receptors_ag","Retinoid X Receptors","ag","14712350",2004,"Retinoic acid receptor alpha and retinoid X receptor specific agonists reduce renal injury in established chronic glomerulonephritis of the rat.","14712350","AGN 195183","Retinoid X Receptors"]
["alantolactone","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","2512929",1989,"In vitro inhibition of mouse hepatic mixed-function oxidase enzymes by helenalin and alantolactone.","2512929","alantolactone","Cytochrome P-450 CYP1A1"]
["Albendazole","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","15849383",2005,"Inhibitory effect of albendazole and its metabolites on cytochromes P450 activities in rat and mouflon in vitro.","15849383","Albendazole","Cytochrome P-450 CYP1A1"]
["alitretinoin","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","10712624",2000,"Light-adaptive effects of retinoic acid on receptive field properties of retinal horizontal cells.","10712624","alitretinoin","Aldehyde Oxidoreductases"]
["alitretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","10585260",1999,"The expression and activity of D-type cyclins in F9 embryonal carcinoma cells: modulation of growth by RXR-selective retinoids.","10585260","alitretinoin","Receptors, Retinoic Acid"]
["alitretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","11261782",2001,"Retinoic acid up-regulates myeloid ICAM-3 expression and function in a cell-specific fashion--evidence for retinoid signaling pathways in the mast cell lineage.","11261782","alitretinoin","Receptors, Retinoic Acid"]
["alitretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","11397803",2001,"Regulation of stearoyl coenzyme A desaturase expression in human retinal pigment epithelial cells by retinoic acid.","11397803","alitretinoin","Receptors, Retinoic Acid"]
["alitretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","11707111",2001,"Engineering orthogonal ligand-receptor pairs from \"near drugs\".","11707111","alitretinoin","Receptors, Retinoic Acid"]
["alitretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","12006550",2002,"Nuclear receptor agonists as potential differentiation therapy agents for human osteosarcoma.","12006550","alitretinoin","Receptors, Retinoic Acid"]
["alitretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","12882839",2003,"Retinoic acids exert direct effects on T cells to suppress Th1 development and enhance Th2 development via retinoic acid receptors.","12882839","alitretinoin","Receptors, Retinoic Acid"]
["alitretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","14975592",2004,"Ligands for the peroxisome proliferator-activated receptor-gamma and the retinoid X receptor exert additive anti-inflammatory effects on experimental autoimmune encephalomyelitis.","14975592","alitretinoin","Receptors, Retinoic Acid"]
["alitretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","14983400",2004,"Retinoic acid increases insulin-like growth factor-binding protein-4 expression in cultured rat hepatocytes.","14983400","alitretinoin","Receptors, Retinoic Acid"]
["alitretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","15546741",2004,"9-cis-retinoic acid analogues with bulky hydrophobic rings: new RXR-selective agonists.","15546741","alitretinoin","Receptors, Retinoic Acid"]
["alitretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","16158052",2006,"Retinoic acid receptors and tissue-transglutaminase mediate short-term effect of retinoic acid on migration and invasion of neuroblastoma SH-SY5Y cells.","16158052","alitretinoin","Receptors, Retinoic Acid"]
["alitretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","16302920",2005,"Retinoic acid is a potential negative regulator for differentiation of human periodontal ligament cells.","16302920","alitretinoin","Receptors, Retinoic Acid"]
["alitretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","9077483",1997,"The retinoid X receptor agonist 9-cis-retinoic acid and the 24-hydroxylase inhibitor ketoconazole increase activity of 1,25-dihydroxyvitamin D3 in human skin in vivo.","9077483","alitretinoin","Receptors, Retinoic Acid"]
["alitretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","9392425",1997,"Mechanism of the slow induction of apolipoprotein A-I synthesis by retinoids in cynomolgus hepatocytes: involvement of retinoic acid and retinoid X receptors.","9392425","alitretinoin","Receptors, Retinoic Acid"]
["alitretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","9816192",1996,"Initial clinical trial of the retinoid receptor pan agonist 9-cis retinoic acid.","9816192","alitretinoin","Receptors, Retinoic Acid"]
["alitretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","9952315",1999,"Greater synergism of retinoic acid receptor (RAR) agonists with vitamin D3 than that of retinoid X receptor (RXR) agonists with regard to growth inhibition and differentiation induction in monoblastic leukemia cells.","9952315","alitretinoin","Receptors, Retinoic Acid"]
["alitretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","10652597",1999,"Different effects of the treatment with AGN 193836 and 9-cis-retinoic acid in breast cancer cells.","10652597","alitretinoin","Receptors, Retinoic Acid"]
["alitretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","12139723",2002,"Superior effect of 9-cis retinoic acid (RA) compared with all-trans RA and 13-cis RA on the inhibition of clonogenic cell growth and the induction of apoptosis in OCI/AML-2 subclones: is the p53 pathway involved?","12139723","alitretinoin","Receptors, Retinoic Acid"]
["alitretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","12882839",2003,"Retinoic acids exert direct effects on T cells to suppress Th1 development and enhance Th2 development via retinoic acid receptors.","12882839","alitretinoin","Receptors, Retinoic Acid"]
["alitretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","16158052",2006,"Retinoic acid receptors and tissue-transglutaminase mediate short-term effect of retinoic acid on migration and invasion of neuroblastoma SH-SY5Y cells.","16158052","alitretinoin","Receptors, Retinoic Acid"]
["alitretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","23485459",2013,"Molecular mechanism of 9-cis-retinoic acid inhibition of adipogenesis in 3T3-L1 cells.","23485459","alitretinoin","Receptors, Retinoic Acid"]
["alitretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","24098526",2013,"Amplified inhibition of stellate cell activation pathways by PPAR-γ, RAR and RXR agonists.","24098526","alitretinoin","Receptors, Retinoic Acid"]
["alitretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","9516856",1997,"Retinoids in neuroblastoma therapy: distinct biological properties of 9-cis- and all-trans-retinoic acid.","9516856","alitretinoin","Receptors, Retinoic Acid"]
["alitretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","9952315",1999,"Greater synergism of retinoic acid receptor (RAR) agonists with vitamin D3 than that of retinoid X receptor (RXR) agonists with regard to growth inhibition and differentiation induction in monoblastic leukemia cells.","9952315","alitretinoin","Receptors, Retinoic Acid"]
["alitretinoin","Retinal Dehydrogenase_antag","Retinal Dehydrogenase","antag","10712624",2000,"Light-adaptive effects of retinoic acid on receptive field properties of retinal horizontal cells.","10712624","alitretinoin","Retinal Dehydrogenase"]
["alitretinoin","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","11397803",2001,"Regulation of stearoyl coenzyme A desaturase expression in human retinal pigment epithelial cells by retinoic acid.","11397803","alitretinoin","retinoic acid receptor alpha"]
["alitretinoin","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","16302920",2005,"Retinoic acid is a potential negative regulator for differentiation of human periodontal ligament cells.","16302920","alitretinoin","retinoic acid receptor alpha"]
["alitretinoin","retinoic acid receptor alpha_antag","retinoic acid receptor alpha","antag","9516856",1997,"Retinoids in neuroblastoma therapy: distinct biological properties of 9-cis- and all-trans-retinoic acid.","9516856","alitretinoin","retinoic acid receptor alpha"]
["alitretinoin","retinoic acid receptor beta_antag","retinoic acid receptor beta","antag","9516856",1997,"Retinoids in neuroblastoma therapy: distinct biological properties of 9-cis- and all-trans-retinoic acid.","9516856","alitretinoin","retinoic acid receptor beta"]
["alitretinoin","Retinoid X Receptor alpha_ag","Retinoid X Receptor alpha","ag","18840407",2008,"9-cis retinoic acid induces retinoid X receptor localized to the mitochondria for mediation of mitochondrial transcription.","18840407","alitretinoin","Retinoid X Receptor alpha"]
["alitretinoin","Retinoid X Receptor alpha_antag","Retinoid X Receptor alpha","antag","23485459",2013,"Molecular mechanism of 9-cis-retinoic acid inhibition of adipogenesis in 3T3-L1 cells.","23485459","alitretinoin","Retinoid X Receptor alpha"]
["alitretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","10585260",1999,"The expression and activity of D-type cyclins in F9 embryonal carcinoma cells: modulation of growth by RXR-selective retinoids.","10585260","alitretinoin","Retinoid X Receptors"]
["alitretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","11397803",2001,"Regulation of stearoyl coenzyme A desaturase expression in human retinal pigment epithelial cells by retinoic acid.","11397803","alitretinoin","Retinoid X Receptors"]
["alitretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","11707111",2001,"Engineering orthogonal ligand-receptor pairs from \"near drugs\".","11707111","alitretinoin","Retinoid X Receptors"]
["alitretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","12006550",2002,"Nuclear receptor agonists as potential differentiation therapy agents for human osteosarcoma.","12006550","alitretinoin","Retinoid X Receptors"]
["alitretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","12882839",2003,"Retinoic acids exert direct effects on T cells to suppress Th1 development and enhance Th2 development via retinoic acid receptors.","12882839","alitretinoin","Retinoid X Receptors"]
["alitretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","14975592",2004,"Ligands for the peroxisome proliferator-activated receptor-gamma and the retinoid X receptor exert additive anti-inflammatory effects on experimental autoimmune encephalomyelitis.","14975592","alitretinoin","Retinoid X Receptors"]
["alitretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","15546741",2004,"9-cis-retinoic acid analogues with bulky hydrophobic rings: new RXR-selective agonists.","15546741","alitretinoin","Retinoid X Receptors"]
["alitretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","16011254",2005,"[Advances in studies on selective RXR ligands].","16011254","alitretinoin","Retinoid X Receptors"]
["alitretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","16302920",2005,"Retinoic acid is a potential negative regulator for differentiation of human periodontal ligament cells.","16302920","alitretinoin","Retinoid X Receptors"]
["alitretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","18594976",2009,"Additive inhibitory effect of experimentally induced hepatic cirrhosis by agonists of peroxisome proliferator activator receptor gamma and retinoic acid receptor.","18594976","alitretinoin","Retinoid X Receptors"]
["alitretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","18755147",2008,"RXR agonists inhibit oxidative stress-induced apoptosis in H9c2 rat ventricular cells.","18755147","alitretinoin","Retinoid X Receptors"]
["alitretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","19409899",2009,"Placental steroidogenesis in rats is independent of signaling pathways induced by retinoic acids.","19409899","alitretinoin","Retinoid X Receptors"]
["alitretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","19644018",2009,"Combined low doses of PPARgamma and RXR ligands trigger an intrinsic apoptotic pathway in human breast cancer cells.","19644018","alitretinoin","Retinoid X Receptors"]
["alitretinoin",{"$f":"C323&\"_\"&D323","v":"Retinoid X Receptors_ag"},"Retinoid X Receptors","ag","19678713",2009,"Alitretinoin: in severe chronic hand eczema.","19678713","alitretinoin","Retinoid X Receptors"]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  I324,I324)","v":"alitretinoin"},"Retinoid X Receptors_ag",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  J324,J324)","v":"Retinoid X Receptors"},"ag",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & H324,H324)","v":"19686701"},2010,"Retinoids activate RXR/CAR-mediated pathway and induce CYP3A.","19686701","alitretinoin","Retinoid X Receptors"]
["alitretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","20417372",2010,"[Alitretinoin: Toctino].","20417372","alitretinoin","Retinoid X Receptors"]
["alitretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","21489804",2011,"Replacement of the hydrophobic part of 9-cis-retinoic acid with cyclic terpenoid moiety results in RXR-selective agonistic activity.","21489804","alitretinoin","Retinoid X Receptors"]
["alitretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","23605322",2013,"Combinational effect of PPARγ agonist and RXR agonist on the growth of SGC7901 gastric carcinoma cells in vitro.","23605322","alitretinoin","Retinoid X Receptors"]
["alitretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","25079278",2014,"Unexpected phenotypes of malformations induced in Xenopus tropicalis embryos by combined exposure to triphenyltin and 9-cis-retinoic acid.","25079278","alitretinoin","Retinoid X Receptors"]
["alitretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","9077483",1997,"The retinoid X receptor agonist 9-cis-retinoic acid and the 24-hydroxylase inhibitor ketoconazole increase activity of 1,25-dihydroxyvitamin D3 in human skin in vivo.","9077483","alitretinoin","Retinoid X Receptors"]
["alitretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","9392425",1997,"Mechanism of the slow induction of apolipoprotein A-I synthesis by retinoids in cynomolgus hepatocytes: involvement of retinoic acid and retinoid X receptors.","9392425","alitretinoin","Retinoid X Receptors"]
["alitretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","9816192",1996,"Initial clinical trial of the retinoid receptor pan agonist 9-cis retinoic acid.","9816192","alitretinoin","Retinoid X Receptors"]
["alitretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","9952315",1999,"Greater synergism of retinoic acid receptor (RAR) agonists with vitamin D3 than that of retinoid X receptor (RXR) agonists with regard to growth inhibition and differentiation induction in monoblastic leukemia cells.","9952315","alitretinoin","Retinoid X Receptors"]
["alitretinoin","Retinoid X Receptors_antag","Retinoid X Receptors","antag","12882839",2003,"Retinoic acids exert direct effects on T cells to suppress Th1 development and enhance Th2 development via retinoic acid receptors.","12882839","alitretinoin","Retinoid X Receptors"]
["alitretinoin","Retinoid X Receptors_antag","Retinoid X Receptors","antag","21654191",2011,"Bid as a potential target of apoptotic effects exerted by low doses of PPARγ and RXR ligands in breast cancer cells.","21654191","alitretinoin","Retinoid X Receptors"]
["alitretinoin","Retinoid X Receptors_antag","Retinoid X Receptors","antag","24098526",2013,"Amplified inhibition of stellate cell activation pathways by PPAR-γ, RAR and RXR agonists.","24098526","alitretinoin","Retinoid X Receptors"]
["alitretinoin","Retinoid X Receptors_antag","Retinoid X Receptors","antag","9952315",1999,"Greater synergism of retinoic acid receptor (RAR) agonists with vitamin D3 than that of retinoid X receptor (RXR) agonists with regard to growth inhibition and differentiation induction in monoblastic leukemia cells.","9952315","alitretinoin","Retinoid X Receptors"]
["alizarin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","12379470",2002,"Inhibition of human cytochrome P450 1B1, 1A1 and 1A2 by antigenotoxic compounds, purpurin and alizarin.","12379470","alizarin","Cytochrome P-450 CYP1A1"]
["Allopurinol","Secretin_antag","Secretin","antag","8460415",1993,"Protective effects of therapy with a protease and xanthine oxidase inhibitor in short form pancreatic biliary obstruction and ischemia in rats.","8460415","Allopurinol","Secretin"]
["allyl isothiocyanate","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","17582584",2008,"Protective effects of isothiocyanates alone or in combination with vitamin C towards N-nitrosodibutylamine or N-nitrosopiperidine-induced oxidative DNA damage in the single-cell gel electrophoresis (SCGE)/HepG2 assay.","17582584","allyl isothiocyanate","Cytochrome P-450 CYP1A1"]
["allyl sulfide","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","11758911",2001,"Modulation of cytochrome P4501-mediated bioactivation of benzo[a]pyrene by volatile allyl sulfides in human hepatoma cells.","11758911","allyl sulfide","Cytochrome P-450 CYP1A1"]
["alpha-ketoisocaproic acid","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","16819942",2006,"Oxo-4-methylpentanoic acid directs the metabolism of GABA into the Krebs cycle in rat pancreatic islets.","16819942","alpha-ketoisocaproic acid","Aldehyde Oxidoreductases"]
["alpha-methylbenzylaminobenzotriazole","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","2276091",1990,"N-aralkylated derivatives of 1-aminobenzotriazole as isozyme-selective, mechanism-based inhibitors of guinea pig hepatic cytochrome P-450 dependent monooxygenase activity.","2276091","alpha-methylbenzylaminobenzotriazole","Cytochrome P-450 CYP1A1"]
["alpha-methylbenzylaminobenzotriazole","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","8246152",1993,"Mechanism-based inactivation of cytochrome P450 1A1 by N-aralkyl-1-aminobenzotriazoles in guinea pig kidney in vivo and in vitro: minimal effects on metabolism of arachidonic acid by renal P450-dependent monooxygenases.","8246152","alpha-methylbenzylaminobenzotriazole","Cytochrome P-450 CYP1A1"]
["alpha-methylbenzylaminobenzotriazole","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","8886610",1996,"Kinetics and selectivity of mechanism-based inhibition of guinea pig hepatic and pulmonary cytochrome P450 by N-benzyl-1-aminobenzotriazole and N-alpha-methylbenzyl-1-aminobenzotriazole.","8886610","alpha-methylbenzylaminobenzotriazole","Cytochrome P-450 CYP1A1"]
["alpha-methylbenzylaminobenzotriazole","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","9660851",1998,"Enantioselective, mechanism-based inactivation of guinea pig hepatic cytochrome P450 by N-(alpha-methylbenzyl)-1-aminobenzotriazole.","9660851","alpha-methylbenzylaminobenzotriazole","Cytochrome P-450 CYP1A1"]
["alpha-methylbenzylaminobenzotriazole","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","9788581",1998,"Effects of inhibitors of CYP1A and CYP2B on styrene metabolism in mouse liver and lung microsomes.","9788581","alpha-methylbenzylaminobenzotriazole","Cytochrome P-450 CYP1A1"]
["alpha-naphthoflavone","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","14709899",2004,"Cytochrome P450 1A1 (CYP1A1) inhibitor alpha-naphthoflavone interferes with UDP-glucuronosyltransferase (UGT) activity in intact but not in permeabilized hepatic microsomes from 3-methylcholanthrene-treated rats: possible involvement of UGT-P450 interactions.","14709899","alpha-naphthoflavone","Cytochrome P-450 CYP1A1"]
["alpha-naphthoflavone","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","17964672",2007,"Synergistic induction of AHR regulated genes in developmental toxicity from co-exposure to two model PAHs in zebrafish.","17964672","alpha-naphthoflavone","Cytochrome P-450 CYP1A1"]
["alpha-naphthoflavone","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","18511136",2008,"Evidence for multiple mechanisms of toxicity in larval rainbow trout (Oncorhynchus mykiss) co-treated with retene and alpha-naphthoflavone.","18511136","alpha-naphthoflavone","Cytochrome P-450 CYP1A1"]
["alpha-naphthoflavone","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","3671887",1987,"Cytochrome P450-dependent alkoxyphenoxazone dealkylase activities in lung microsomes from untreated and beta-naphthoflavone-treated rats: effect of in vitro inhibitors.","3671887","alpha-naphthoflavone","Cytochrome P-450 CYP1A1"]
["alpha-naphthoflavone","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","7599976",1995,"Inhibition of in vitro aflatoxin B1-DNA binding in rainbow trout by CYP1A inhibitors: alpha-naphthoflavone, beta-naphthoflavone and trout CYP1A1 peptide antibody.","7599976","alpha-naphthoflavone","Cytochrome P-450 CYP1A1"]
["alpha-naphthoflavone","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","9784250",1998,"Induction of cytochrome P-450 1A1 by omeprazole in human HepG2 cells is protein tyrosine kinase-dependent and is not inhibited by alpha-naphthoflavone.","9784250","alpha-naphthoflavone","Cytochrome P-450 CYP1A1"]
["alpha-naphthoflavone","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","9788581",1998,"Effects of inhibitors of CYP1A and CYP2B on styrene metabolism in mouse liver and lung microsomes.","9788581","alpha-naphthoflavone","Cytochrome P-450 CYP1A1"]
["alpha-terpineol","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","10454222",1999,"In vitro inhibition of liver monooxygenases by beta-ionone, 1,8-cineole, (-)-menthol and terpineol.","10454222","alpha-terpineol","Cytochrome P-450 CYP1A1"]
["ALRT 1550","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","8709094",1996,"Discovery of novel retinoic acid receptor agonists having potent antiproliferative activity in cervical cancer cells.","8709094","ALRT 1550","Receptors, Retinoic Acid"]
["ALRT 1550","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","8988059",1997,"A novel retinoic acid receptor-selective retinoid, ALRT1550, has potent antitumor activity against human oral squamous carcinoma xenografts in nude mice.","8988059","ALRT 1550","Receptors, Retinoic Acid"]
["ALRT 1550","Retinoid X Receptors_ag","Retinoid X Receptors","ag","8709094",1996,"Discovery of novel retinoic acid receptor agonists having potent antiproliferative activity in cervical cancer cells.","8709094","ALRT 1550","Retinoid X Receptors"]
["alyssin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","19202560",2009,"Sulforaphane and its analogues inhibit CYP1A1 and CYP1A2 activity induced by benzo[a]pyrene.","19202560","alyssin","Cytochrome P-450 CYP1A1"]
["Am 580","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","10663386",2000,"Selective agonists of retinoic acid receptors: comparative toxicokinetics and embryonic exposure.","10663386","Am 580","Receptors, Retinoic Acid"]
["Am 580","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","11726401",2001,"Effects of retinoic acid receptor-selective agonists on human nasal epithelial cell differentiation.","11726401","Am 580","Receptors, Retinoic Acid"]
["Am 580","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","12169446",2002,"Enhancement of the inducible NO synthase activation by retinoic acid is mimicked by RARalpha agonist in vivo.","12169446","Am 580","Receptors, Retinoic Acid"]
["Am 580","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","17290005",2007,"A widely used retinoic acid receptor antagonist induces peroxisome proliferator-activated receptor-gamma activity.","17290005","Am 580","Receptors, Retinoic Acid"]
["Am 580","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","19790202",2009,"Synthesis and pharmacological characterization of Disila-AM80 (Disila-tamibarotene) and Disila-AM580, silicon analogues of the RARalpha-selective retinoid agonists AM80 (Tamibarotene) and AM580.","19790202","Am 580","Receptors, Retinoic Acid"]
["Am 580","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","20453882",2010,"Mechanism of inhibition of MMTV-neu and MMTV-wnt1 induced mammary oncogenesis by RARalpha agonist AM580.","20453882","Am 580","Receptors, Retinoic Acid"]
["Am 580","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","22258322",2012,"Roflumilast enhances the renal protective effects of retinoids in an HIV-1 transgenic mouse model of rapidly progressive renal failure.","22258322","Am 580","Receptors, Retinoic Acid"]
["Am 580","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","22920668",2012,"Reversal by RARα agonist Am580 of c-Myc-induced imbalance in RARα/RARγ expression during MMTV-Myc tumorigenesis.","22920668","Am 580","Receptors, Retinoic Acid"]
["Am 580","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","23395853",2013,"Activation of retinoid receptor-mediated signaling ameliorates diabetes-induced cardiac dysfunction in Zucker diabetic rats.","23395853","Am 580","Receptors, Retinoic Acid"]
["Am 580","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","8759622",1996,"Identification of a retinoic acid receptor alpha subtype specific agonist.","8759622","Am 580","Receptors, Retinoic Acid"]
["Am 580","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","9439352",1998,"A retinoic acid receptor-alpha (RAR alpha) selective agonist modulates procoagulant activity of acute promyelocytic cells and induces their differentiation into neutrophils.","9439352","Am 580","Receptors, Retinoic Acid"]
["Am 580","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","17290005",2007,"A widely used retinoic acid receptor antagonist induces peroxisome proliferator-activated receptor-gamma activity.","17290005","Am 580","Receptors, Retinoic Acid"]
["Am 580","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","23925292",2013,"Retinoids activate the irritant receptor TRPV1 and produce sensory hypersensitivity.","23925292","Am 580","Receptors, Retinoic Acid"]
["Am 580","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","8284797",1994,"A retinoic acid receptor alpha antagonist counteracts retinoid teratogenicity in vitro and reduced incidence and/or severity of malformations in vivo.","8284797","Am 580","Receptors, Retinoic Acid"]
["Am 580","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","11726401",2001,"Effects of retinoic acid receptor-selective agonists on human nasal epithelial cell differentiation.","11726401","Am 580","retinoic acid receptor alpha"]
["Am 580","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","12169446",2002,"Enhancement of the inducible NO synthase activation by retinoic acid is mimicked by RARalpha agonist in vivo.","12169446","Am 580","retinoic acid receptor alpha"]
["Am 580","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","17290005",2007,"A widely used retinoic acid receptor antagonist induces peroxisome proliferator-activated receptor-gamma activity.","17290005","Am 580","retinoic acid receptor alpha"]
["Am 580","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","19790202",2009,"Synthesis and pharmacological characterization of Disila-AM80 (Disila-tamibarotene) and Disila-AM580, silicon analogues of the RARalpha-selective retinoid agonists AM80 (Tamibarotene) and AM580.","19790202","Am 580","retinoic acid receptor alpha"]
["Am 580","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","20453882",2010,"Mechanism of inhibition of MMTV-neu and MMTV-wnt1 induced mammary oncogenesis by RARalpha agonist AM580.","20453882","Am 580","retinoic acid receptor alpha"]
["Am 580","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","22258322",2012,"Roflumilast enhances the renal protective effects of retinoids in an HIV-1 transgenic mouse model of rapidly progressive renal failure.","22258322","Am 580","retinoic acid receptor alpha"]
["Am 580","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","22920668",2012,"Reversal by RARα agonist Am580 of c-Myc-induced imbalance in RARα/RARγ expression during MMTV-Myc tumorigenesis.","22920668","Am 580","retinoic acid receptor alpha"]
["Am 580","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","8759622",1996,"Identification of a retinoic acid receptor alpha subtype specific agonist.","8759622","Am 580","retinoic acid receptor alpha"]
["Am 580","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","9439352",1998,"A retinoic acid receptor-alpha (RAR alpha) selective agonist modulates procoagulant activity of acute promyelocytic cells and induces their differentiation into neutrophils.","9439352","Am 580","retinoic acid receptor alpha"]
["Am 580","retinoic acid receptor alpha_antag","retinoic acid receptor alpha","antag","17290005",2007,"A widely used retinoic acid receptor antagonist induces peroxisome proliferator-activated receptor-gamma activity.","17290005","Am 580","retinoic acid receptor alpha"]
["Am 580","retinoic acid receptor beta_ag","retinoic acid receptor beta","ag","11726401",2001,"Effects of retinoic acid receptor-selective agonists on human nasal epithelial cell differentiation.","11726401","Am 580","retinoic acid receptor beta"]
["Am 580","retinoic acid receptor gamma_ag","retinoic acid receptor gamma","ag","11726401",2001,"Effects of retinoic acid receptor-selective agonists on human nasal epithelial cell differentiation.","11726401","Am 580","retinoic acid receptor gamma"]
["Am 580","retinoic acid receptor gamma_ag","retinoic acid receptor gamma","ag","22920668",2012,"Reversal by RARα agonist Am580 of c-Myc-induced imbalance in RARα/RARγ expression during MMTV-Myc tumorigenesis.","22920668","Am 580","retinoic acid receptor gamma"]
["Am 580","Retinoid X Receptors_ag","Retinoid X Receptors","ag","12169446",2002,"Enhancement of the inducible NO synthase activation by retinoic acid is mimicked by RARalpha agonist in vivo.","12169446","Am 580","Retinoid X Receptors"]
["Am 580",{"$f":"C387&\"_\"&D387","v":"Retinoid X Receptors_ag"},"Retinoid X Receptors","ag","23395853",2013,"Activation of retinoid receptor-mediated signaling ameliorates diabetes-induced cardiac dysfunction in Zucker diabetic rats.","23395853","Am 580","Retinoid X Receptors"]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  I388,I388)","v":"Am 580"},"Retinoid X Receptors_ag",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  J388,J388)","v":"Retinoid X Receptors"},"ag",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & H388,H388)","v":"8759622"},1996,"Identification of a retinoic acid receptor alpha subtype specific agonist.","8759622","Am 580","Retinoid X Receptors"]
["Amiloride","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","15081870",2004,"Inhibition of carcinogen-bioactivating cytochrome P450 1 isoforms by amiloride derivatives.","15081870","Amiloride","Cytochrome P-450 CYP1A1"]
["aminobenzothiazole compound","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","23088909",2012,"Synthesis of retinoid enhancers based on 2-aminobenzothiazoles for anti-cancer therapy.","23088909","aminobenzothiazole compound","Receptors, Retinoic Acid"]
["aminobenzothiazole compound","retinoic acid receptor, beta2, human_ag","retinoic acid receptor, beta2, human","ag","23088909",2012,"Synthesis of retinoid enhancers based on 2-aminobenzothiazoles for anti-cancer therapy.","23088909","aminobenzothiazole compound","retinoic acid receptor, beta2, human"]
["Amiodarone","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","20201781",2010,"Assessment of the inactivation potential of desethylamiodarone on human CYP1A1.","20201781","Amiodarone","Cytochrome P-450 CYP1A1"]
["Amiodarone","retinyl esterase_antag","retinyl esterase","antag","16277768",2005,"A comparative study on the effects of oral amiodarone and trimeprazine, two in vitro retinyl ester hydrolase inhibitors, on the metabolic availability of vitamin A in rats.","16277768","Amiodarone","retinyl esterase"]
["Ammonium Chloride","Retinoblastoma Protein_antag","Retinoblastoma Protein","antag","10966487",2000,"Modification of the epidermal growth factor response by ammonia in renal cell hypertrophy.","10966487","Ammonium Chloride","Retinoblastoma Protein"]
["Amphetamine","Retinoid X Receptors_antag","Retinoid X Receptors","antag","18843482",2009,"The transcription factors Nur77 and retinoid X receptors participate in amphetamine-induced locomotor activities.","18843482","Amphetamine","Retinoid X Receptors"]
["Amsacrine","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","6689124",1983,"An extremely potent anilinoacridine inhibitor of aldehyde oxidase.","6689124","Amsacrine","Aldehyde Oxidoreductases"]
["andrographolide","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","19126299",2009,"Andrographolide inhibits growth of acute promyelocytic leukaemia cells by inducing retinoic acid receptor-independent cell differentiation and apoptosis.","19126299","andrographolide","Receptors, Retinoic Acid"]
["andrographolide","retinoic acid receptor alpha_antag","retinoic acid receptor alpha","antag","19126299",2009,"Andrographolide inhibits growth of acute promyelocytic leukaemia cells by inducing retinoic acid receptor-independent cell differentiation and apoptosis.","19126299","andrographolide","retinoic acid receptor alpha"]
["anhydrovitamin A","retinol dehydratase_antag","retinol dehydratase","antag","15608121",2005,"The structures of the unique sulfotransferase retinol dehydratase with product and inhibitors provide insight into enzyme mechanism and inhibition.","15608121","anhydrovitamin A","retinol dehydratase"]
["anthra(1,9-cd)pyrazol-6(2H)-one","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","14570754",2003,"The Jun N-terminal kinase inhibitor SP600125 is a ligand and antagonist of the aryl hydrocarbon receptor.","14570754","anthra(1,9-cd)pyrazol-6(2H)-one","Cytochrome P-450 CYP1A1"]
["Apigenin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","11752233",2002,"Flavonoids inhibit genetic toxicity produced by carcinogens in cells expressing CYP1A2 and CYP1A1.","11752233","Apigenin","Cytochrome P-450 CYP1A1"]
["apo-14'-carotenoic acid","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","22418437",2012,"Naturally occurring eccentric cleavage products of provitamin A β-carotene function as antagonists of retinoic acid receptors.","22418437","apo-14'-carotenoic acid","Receptors, Retinoic Acid"]
["apo-14'-carotenoic acid","retinoic acid receptor beta_antag","retinoic acid receptor beta","antag","22418437",2012,"Naturally occurring eccentric cleavage products of provitamin A β-carotene function as antagonists of retinoic acid receptors.","22418437","apo-14'-carotenoic acid","retinoic acid receptor beta"]
["Arecoline","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","17707585",2007,"Differential effect of arecoline on the endogenous dioxin-responsive cytochrome P450 1A1 and on a stably transfected dioxin-responsive element-driven reporter in human hepatoma cells.","17707585","Arecoline","Cytochrome P-450 CYP1A1"]
["aristolochic acid I","CYP1A1 protein, human_antag","CYP1A1 protein, human","antag","22086975",2012,"Bioactivation versus detoxication of the urothelial carcinogen aristolochic acid I by human cytochrome P450 1A1 and 1A2.","22086975","aristolochic acid I","CYP1A1 protein, human"]
["aristolochic acid I","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","22086975",2012,"Bioactivation versus detoxication of the urothelial carcinogen aristolochic acid I by human cytochrome P450 1A1 and 1A2.","22086975","aristolochic acid I","Cytochrome P-450 CYP1A1"]
["Arsenic","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","6301524",1983,"Electron paramagnetic resonance and potentiometric studies of arsenite interaction with the molybdenum centers of xanthine oxidase, xanthine dehydrogenase, and aldehyde oxidase: a specific stabilization of the molybdenum(V) oxidation state.","6301524","Arsenic","Aldehyde Oxidoreductases"]
["Arsenic","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","8431965",1993,"Effects of acute sodium arsenite administration on the pulmonary chemical metabolizing enzymes, cytochrome P-450 monooxygenase, NAD(P)H:quinone acceptor oxidoreductase and glutathione S-transferase in guinea pig: comparison with effects in liver and kidney.","8431965","Arsenic","Cytochrome P-450 CYP1A1"]
["arsenic trioxide","promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein_antag","promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein","antag","10830735",2000,"Arsenic trioxide therapy for relapsed acute promyelocytic leukemia: an useful salvage therapy.","10830735","arsenic trioxide","promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein"]
["arsenic trioxide","promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein_antag","promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein","antag","17468032",2007,"Acute promyelocytic leukemia: new issues on pathogenesis and treatment response.","17468032","arsenic trioxide","promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein"]
["arsenic trioxide","promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein_antag","promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein","antag","17929112",2007,"PML-RARalpha inhibitors (ATRA, tamibaroten, arsenic troxide) for acute promyelocytic leukemia.","17929112","arsenic trioxide","promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein"]
["arsenic trioxide","promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein_antag","promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein","antag","20509866",2010,"Sweet fruit from a poisonous kiss.","20509866","arsenic trioxide","promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein"]
["arsenic trioxide","promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein_antag","promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein","antag","24825822",2014,"In the war against solid tumors arsenic trioxide needs partners.","24825822","arsenic trioxide","promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein"]
["arsenite","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","17139522",2007,"Correlating EPR and X-ray structural analysis of arsenite-inhibited forms of aldehyde oxidoreductase.","17139522","arsenite","Aldehyde Oxidoreductases"]
["arsenite","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","2297350",1990,"Nicotinamide adenine dinucleotide (NAD)-dependent oxidation of nicotine-delta 1'(5')-iminium ion to cotinine by rabbit liver microsomes.","2297350","arsenite","Aldehyde Oxidoreductases"]
["arsenite","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","6301524",1983,"Electron paramagnetic resonance and potentiometric studies of arsenite interaction with the molybdenum centers of xanthine oxidase, xanthine dehydrogenase, and aldehyde oxidase: a specific stabilization of the molybdenum(V) oxidation state.","6301524","arsenite","Aldehyde Oxidoreductases"]
["arsenite","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","7157414",1982,"Inhibition of mitochondrial aldehyde dehydrogenase by malondialdehyde.","7157414","arsenite","Aldehyde Oxidoreductases"]
["arsenite","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","15576448",2005,"Mechanisms of arsenite-mediated decreases in benzo[k]fluoranthene-induced human cytochrome P4501A1 levels in HepG2 cells.","15576448","arsenite","Cytochrome P-450 CYP1A1"]
["arsenite","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","15630080",2005,"Arsenite inhibition of CYP1A1 induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin is independent of cell cycle arrest.","15630080","arsenite","Cytochrome P-450 CYP1A1"]
["arsenite","Retinoid X Receptor alpha_antag","Retinoid X Receptor alpha","antag","15833926",2005,"Arsenite decreases CYP3A4 and RXRalpha in primary human hepatocytes.","15833926","arsenite","Retinoid X Receptor alpha"]
["Ascorbic Acid","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","17582584",2008,"Protective effects of isothiocyanates alone or in combination with vitamin C towards N-nitrosodibutylamine or N-nitrosopiperidine-induced oxidative DNA damage in the single-cell gel electrophoresis (SCGE)/HepG2 assay.","17582584","Ascorbic Acid","Cytochrome P-450 CYP1A1"]
["Ascorbic Acid","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","8346921",1993,"Ascorbic acid inhibition of cytochrome P450-catalyzed uroporphyrin accumulation.","8346921","Ascorbic Acid","Cytochrome P-450 CYP1A1"]
["Aspirin","Secretin_antag","Secretin","antag","7899465",1995,"Aspirin inhibits secretagogue-stimulated and postprandial pancreatic exocrine secretion in conscious rats.","7899465","Aspirin","Secretin"]
["Aspirin","Secretin_antag","Secretin","antag","8361960",1993,"Does acetylsalicylic acid interfere with stimulated pancreatic secretion? An experimental study in the rat.","8361960","Aspirin","Secretin"]
["Atracurium","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","7903450",1993,"Inhibition of hepatic microsomal drug metabolism by atracurium administration in the rat.","7903450","Atracurium","Cytochrome P-450 CYP1A1"]
["Atropine","Secretin_antag","Secretin","antag","2890695",1987,"Role of secretin and CCK in the stimulation of pancreatic secretion in conscious dogs. Effects of atropine and somatostatin.","2890695","Atropine","Secretin"]
["avarol","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","1853363",1991,"Effect of avarol, avarone and nine of their natural and synthetic derivatives on microsomal drug-metabolizing enzymes.","1853363","avarol","Cytochrome P-450 CYP1A1"]
["avarone","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","1853363",1991,"Effect of avarol, avarone and nine of their natural and synthetic derivatives on microsomal drug-metabolizing enzymes.","1853363","avarone","Cytochrome P-450 CYP1A1"]
["avasimibe","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","15333513",2004,"Effects of avasimibe on cytochrome P450 2C9 expression in vitro and in vivo.","15333513","avasimibe","Cytochrome P-450 CYP1A1"]
["Azaguanine","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","4420822",1974,"Xanthine dehydrogenase activity in starved-refed rats treated with 8-azaguanine.","4420822","Azaguanine","Aldehyde Oxidoreductases"]
["Barium","Secretin_antag","Secretin","antag","3822758",1986,"Intraepithelial current flow in rat pancreatic secretory epithelia.","3822758","Barium","Secretin"]
["Benserazide","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","196537",1976,"Studies on the effects of pyrogallol and the structurally related dopa decarboxylase inhibitor RO4-4602 on acetaldehyde metabolism.","196537","Benserazide","Aldehyde Oxidoreductases"]
["Benzo(a)pyrene","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","10434373",1999,"Effects of aflatoxin B1 on the hepatic microsomal mixed function oxidase system during phenobarbital and benzo(a)pyrene treatment in chickens.","10434373","Benzo(a)pyrene","Cytochrome P-450 CYP1A1"]
["Benzo(a)pyrene","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","10825463",2000,"Effect of 3'-methoxy-4'-nitroflavone on benzo[a]pyrene toxicity. Aryl hydrocarbon receptor-dependent and -independent mechanisms.","10825463","Benzo(a)pyrene","Cytochrome P-450 CYP1A1"]
["Benzo(a)pyrene","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","11159744",2001,"Oral administration of naturally occurring coumarins leads to altered phase I and II enzyme activities and reduced DNA adduct formation by polycyclic aromatic hydrocarbons in various tissues of SENCAR mice.","11159744","Benzo(a)pyrene","Cytochrome P-450 CYP1A1"]
["Benzo(a)pyrene","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","11159756",2001,"Aryl hydrocarbon receptor signaling plays a significant role in mediating benzo[a]pyrene- and cigarette smoke condensate-induced cytogenetic damage in vivo.","11159756","Benzo(a)pyrene","Cytochrome P-450 CYP1A1"]
["Benzo(a)pyrene","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","11752233",2002,"Flavonoids inhibit genetic toxicity produced by carcinogens in cells expressing CYP1A2 and CYP1A1.","11752233","Benzo(a)pyrene","Cytochrome P-450 CYP1A1"]
["Benzo(a)pyrene","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","12127040",2002,"Benzo(a)pyrene exposure induces CYP1A1 activity and expression in human endometrial cells.","12127040","Benzo(a)pyrene","Cytochrome P-450 CYP1A1"]
["Benzo(a)pyrene","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","12453661",2003,"Human intestinal Caco-2 cells display active transport of benzo[a]pyrene metabolites.","12453661","Benzo(a)pyrene","Cytochrome P-450 CYP1A1"]
["Benzo(a)pyrene","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","12787821",2003,"Inhibition of clastogenicity of benzo[a]pyrene and of its trans-7,8-dihydrodiol in mice in vivo by fruits, vegetables, and flavonoids.","12787821","Benzo(a)pyrene","Cytochrome P-450 CYP1A1"]
["Benzo(a)pyrene","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","14656999",2004,"Identification of Na+/H+ exchange as a new target for toxic polycyclic aromatic hydrocarbons.","14656999","Benzo(a)pyrene","Cytochrome P-450 CYP1A1"]
["Benzo(a)pyrene","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","15081870",2004,"Inhibition of carcinogen-bioactivating cytochrome P450 1 isoforms by amiloride derivatives.","15081870","Benzo(a)pyrene","Cytochrome P-450 CYP1A1"]
["Benzo(a)pyrene","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","15178106",2004,"Suppressive effects of benzo[a]pyrene upon fish immune function: evolutionarily conserved cellular mechanisms of immunotoxicity.","15178106","Benzo(a)pyrene","Cytochrome P-450 CYP1A1"]
["Benzo(a)pyrene","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","16484233",2006,"Inhibition of benzo[a]pyrene-activating enzymes and DNA binding in human bronchial epithelial BEAS-2B cells by methoxylated flavonoids.","16484233","Benzo(a)pyrene","Cytochrome P-450 CYP1A1"]
["Benzo(a)pyrene","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","16541199",2006,"Involvement of endogenous nitric oxide in myeloperoxidase mediated benzo(a)pyrene induced polymorphonuclear leukocytes injury.","16541199","Benzo(a)pyrene","Cytochrome P-450 CYP1A1"]
["Benzo(a)pyrene","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","17433523",2007,"Abundance of aryl hydrocarbon receptor potentiates benzo[a]pyrene-induced apoptosis in Hepa1c1c7 cells via CYP1A1 activation.","17433523","Benzo(a)pyrene","Cytochrome P-450 CYP1A1"]
["Benzo(a)pyrene","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","17991490",2007,"The involvement of secondary signaling molecules in cytochrome P-450 1A1-mediated inducible nitric oxide synthase expression in benzo(a)pyrene-treated rat polymorphonuclear leukocytes.","17991490","Benzo(a)pyrene","Cytochrome P-450 CYP1A1"]
["Benzo(a)pyrene","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","18479797",2008,"Antigenotoxic properties of Eruca sativa (rocket plant), erucin and erysolin in human hepatoma (HepG2) cells towards benzo(a)pyrene and their mode of action.","18479797","Benzo(a)pyrene","Cytochrome P-450 CYP1A1"]
["Benzo(a)pyrene","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","19202560",2009,"Sulforaphane and its analogues inhibit CYP1A1 and CYP1A2 activity induced by benzo[a]pyrene.","19202560","Benzo(a)pyrene","Cytochrome P-450 CYP1A1"]
["Benzo(a)pyrene","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","19269699",2009,"Effect of CYP1A inhibition on the biotransformation of benzo[a]pyrene in two populations of Fundulus heteroclitus with different exposure histories.","19269699","Benzo(a)pyrene","Cytochrome P-450 CYP1A1"]
["Benzo(a)pyrene",{"$f":"C451&\"_\"&D451","v":"Cytochrome P-450 CYP1A1_antag"},"Cytochrome P-450 CYP1A1","antag","19386251",2009,"Effect of PCB153 on BaP-induced genotoxicity in HepG2 cells via modulation of metabolic enzymes.","19386251","Benzo(a)pyrene","Cytochrome P-450 CYP1A1"]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  I452,I452)","v":"Benzo(a)pyrene"},"Cytochrome P-450 CYP1A1_antag",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  J452,J452)","v":"Cytochrome P-450 CYP1A1"},"antag",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & H452,H452)","v":"19571387"},2009,"Anti-clastogenic effect of magnolol-containing Hange-koboku-to, Dai-joki-to, Goshaku-san, and Magnoliae Cortex on benzo(a)pyrene-induced clastogenicity in mice.","19571387","Benzo(a)pyrene","Cytochrome P-450 CYP1A1"]
["Benzo(a)pyrene","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","22951985",2012,"Activation of the aryl hydrocarbon receptor sensitises human keratinocytes for CD95L- and TRAIL-induced apoptosis.","22951985","Benzo(a)pyrene","Cytochrome P-450 CYP1A1"]
["Benzo(a)pyrene","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","24397434",2014,"Complex interactions between dioxin-like and non-dioxin-like compounds for in vitro cellular responses: implications for the identification of dioxin exposure biomarkers.","24397434","Benzo(a)pyrene","Cytochrome P-450 CYP1A1"]
["Benzo(a)pyrene","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","25805023",2015,"Inhibition of β-catenin signalling promotes DNA damage elicited by benzo[a]pyrene in a model of human colon cancer cells via CYP1 deregulation.","25805023","Benzo(a)pyrene","Cytochrome P-450 CYP1A1"]
["benzo(a)pyrene 7,8-dihydrodiol","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","12787821",2003,"Inhibition of clastogenicity of benzo[a]pyrene and of its trans-7,8-dihydrodiol in mice in vivo by fruits, vegetables, and flavonoids.","12787821","benzo(a)pyrene 7,8-dihydrodiol","Cytochrome P-450 CYP1A1"]
["benzo(a)pyrene 7,8-dihydrodiol","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","15637092",2005,"Modulation of the metabolism and adverse effects of benzo[a]pyrene by a specific antibody: a novel host factor in environmental carcinogenesis?","15637092","benzo(a)pyrene 7,8-dihydrodiol","Cytochrome P-450 CYP1A1"]
["benzo(a)pyrene-DNA adduct","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","11159744",2001,"Oral administration of naturally occurring coumarins leads to altered phase I and II enzyme activities and reduced DNA adduct formation by polycyclic aromatic hydrocarbons in various tissues of SENCAR mice.","11159744","benzo(a)pyrene-DNA adduct","Cytochrome P-450 CYP1A1"]
["benzo(d)thiazol-2-amine","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","25563891",2015,"Synthesis and anticancer evaluation of novel triazole linked N-(pyrimidin-2-yl)benzo[d]thiazol-2-amine derivatives as inhibitors of cell survival proteins and inducers of apoptosis in MCF-7 breast cancer cells.","25563891","benzo(d)thiazol-2-amine","Cytochrome P-450 CYP1A1"]
["benzochromenyl retinoid","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","10201840",1999,"A new class of potent RAR antagonists: dihydroanthracenyl, benzochromenyl and benzothiochromenyl retinoids.","10201840","benzochromenyl retinoid","Receptors, Retinoic Acid"]
["benzofuran","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","19350615",2009,"Highly potent naphthofuran-based retinoic acid receptor agonists.","19350615","benzofuran","Receptors, Retinoic Acid"]
["Benzoic Acid","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","26209236",2015,"Pharmacological In Vivo Inhibition of S-Nitrosoglutathione Reductase Attenuates Bleomycin-Induced Inflammation and Fibrosis.","26209236","Benzoic Acid","Aldehyde Oxidoreductases"]
["benzothiazole","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","12926251",2003,"Antitumor benzothiazoles. Frontier molecular orbital analysis predicts bioactivation of 2-(4-aminophenyl)benzothiazoles to reactive intermediates by cytochrome P4501A1.","12926251","benzothiazole","Cytochrome P-450 CYP1A1"]
["benzothiochromenyl retinoid","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","10201840",1999,"A new class of potent RAR antagonists: dihydroanthracenyl, benzochromenyl and benzothiochromenyl retinoids.","10201840","benzothiochromenyl retinoid","Receptors, Retinoic Acid"]
["benzyl selenocyanate","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","21732699",2011,"Spectral modification and catalytic inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2A6, and 2A13 by four chemopreventive organoselenium compounds.","21732699","benzyl selenocyanate","Cytochrome P-450 CYP1A1"]
["bepafant","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","15674364",2005,"WEB-2086 and WEB-2170 trigger apoptosis in both ATRA-sensitive and -resistant promyelocytic leukemia cells and greatly enhance ATRA differentiation potential.","15674364","bepafant","Receptors, Retinoic Acid"]
["Berberine","CYP1A1 protein, human_antag","CYP1A1 protein, human","antag","23886934",2013,"Inhibition of CYP1 by berberine, palmatine, and jatrorrhizine: selectivity, kinetic characterization, and molecular modeling.","23886934","Berberine","CYP1A1 protein, human"]
["Berberine","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","21802525",2011,"Inhibition of CYP450 1A and 3A by berberine in crucian carp Carassius auratus gibelio.","21802525","Berberine","Cytochrome P-450 CYP1A1"]
["Berberine","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","23886934",2013,"Inhibition of CYP1 by berberine, palmatine, and jatrorrhizine: selectivity, kinetic characterization, and molecular modeling.","23886934","Berberine","Cytochrome P-450 CYP1A1"]
["bergamottin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","22705772",2012,"Bergamottin is a competitive inhibitor of CYP1A1 and is antimutagenic in the Ames test.","22705772","bergamottin","Cytochrome P-450 CYP1A1"]
["beta Carotene","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","25629601",2015,"The inhibition of macrophage foam cell formation by 9-cis β-carotene is driven by BCMO1 activity.","25629601","beta Carotene","Receptors, Retinoic Acid"]
["beta Carotene","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","26516892",2015,"Combined Effects of Soy Isoflavones and β-Carotene on Osteoblast Differentiation.","26516892","beta Carotene","Receptors, Retinoic Acid"]
["beta-apo-13-carotenone","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","22418437",2012,"Naturally occurring eccentric cleavage products of provitamin A β-carotene function as antagonists of retinoic acid receptors.","22418437","beta-apo-13-carotenone","Receptors, Retinoic Acid"]
["beta-apo-13-carotenone","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","25602703",2015,"Actions of β-apo-carotenoids in differentiating cells: differential effects in P19 cells and 3T3-L1 adipocytes.","25602703","beta-apo-13-carotenone","Receptors, Retinoic Acid"]
["beta-apo-13-carotenone","retinoic acid receptor beta_antag","retinoic acid receptor beta","antag","22418437",2012,"Naturally occurring eccentric cleavage products of provitamin A β-carotene function as antagonists of retinoic acid receptors.","22418437","beta-apo-13-carotenone","retinoic acid receptor beta"]
["beta-apo-13-carotenone","Retinoid X Receptor alpha_ag","Retinoid X Receptor alpha","ag","20678466",2010,"The eccentric cleavage product of β-carotene, β-apo-13-carotenone, functions as an antagonist of RXRα.","20678466","beta-apo-13-carotenone","Retinoid X Receptor alpha"]
["beta-apo-13-carotenone","Retinoid X Receptor alpha_antag","Retinoid X Receptor alpha","antag","20678466",2010,"The eccentric cleavage product of β-carotene, β-apo-13-carotenone, functions as an antagonist of RXRα.","20678466","beta-apo-13-carotenone","Retinoid X Receptor alpha"]
["beta-apo-13-carotenone","Retinoid X Receptor alpha_antag","Retinoid X Receptor alpha","antag","25324544",2014,"β-Apo-13-carotenone regulates retinoid X receptor transcriptional activity through tetramerization of the receptor.","25324544","beta-apo-13-carotenone","Retinoid X Receptor alpha"]
["beta-apo-14'-carotenal","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","22418437",2012,"Naturally occurring eccentric cleavage products of provitamin A β-carotene function as antagonists of retinoic acid receptors.","22418437","beta-apo-14'-carotenal","Receptors, Retinoic Acid"]
["beta-apo-14'-carotenal","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","25602703",2015,"Actions of β-apo-carotenoids in differentiating cells: differential effects in P19 cells and 3T3-L1 adipocytes.","25602703","beta-apo-14'-carotenal","Receptors, Retinoic Acid"]
["beta-apo-14'-carotenal","retinoic acid receptor beta_antag","retinoic acid receptor beta","antag","22418437",2012,"Naturally occurring eccentric cleavage products of provitamin A β-carotene function as antagonists of retinoic acid receptors.","22418437","beta-apo-14'-carotenal","retinoic acid receptor beta"]
["Betaine","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","9300808",1997,"Substrate inhibition by betaine aldehyde of betaine aldehyde dehydrogenase from leaves of Amaranthus hypochondriacus L.","9300808","Betaine","Aldehyde Oxidoreductases"]
["betaine aldehyde","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","9300808",1997,"Substrate inhibition by betaine aldehyde of betaine aldehyde dehydrogenase from leaves of Amaranthus hypochondriacus L.","9300808","betaine aldehyde","Aldehyde Oxidoreductases"]
["beta-ionone","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","10454222",1999,"In vitro inhibition of liver monooxygenases by beta-ionone, 1,8-cineole, (-)-menthol and terpineol.","10454222","beta-ionone","Cytochrome P-450 CYP1A1"]
["beta-ionone","retinol dehydrogenase_antag","retinol dehydrogenase","antag","7947785",1994,"Rod outer segment retinol dehydrogenase: substrate specificity and role in phototransduction.","7947785","beta-ionone","retinol dehydrogenase"]
["beta-Naphthoflavone","CYP1A1 protein, human_antag","CYP1A1 protein, human","antag","22495716",2012,"Activation of aryl hydrocarbon receptor suppresses invasion of esophageal squamous  cell carcinoma cell lines.","22495716","beta-Naphthoflavone","CYP1A1 protein, human"]
["beta-Naphthoflavone","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","10510742",1999,"Preferential inhibition of CYP1A enzymes in hepatic microsomes by mexiletine.","10510742","beta-Naphthoflavone","Cytochrome P-450 CYP1A1"]
["beta-Naphthoflavone","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","11006352",2000,"Influence of beta-naphthoflavone on 7,12-dimethylbenz(a)anthracene metabolism, DNA adduction, and tumorigenicity in rainbow trout.","11006352","beta-Naphthoflavone","Cytochrome P-450 CYP1A1"]
["beta-Naphthoflavone","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","11076701",2000,"Differential response of cultured human umbilical vein and artery endothelial cells to Ah receptor agonist treatment: CYP-dependent activation of food and environmental mutagens.","11076701","beta-Naphthoflavone","Cytochrome P-450 CYP1A1"]
["beta-Naphthoflavone","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","17964672",2007,"Synergistic induction of AHR regulated genes in developmental toxicity from co-exposure to two model PAHs in zebrafish.","17964672","beta-Naphthoflavone","Cytochrome P-450 CYP1A1"]
["beta-Naphthoflavone","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","19252307",2009,"Involvement of the CYP1A subfamily in stereoselective metabolism of carvedilol in beta-naphthoflavone-treated Caco-2 cells.","19252307","beta-Naphthoflavone","Cytochrome P-450 CYP1A1"]
["beta-Naphthoflavone","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","22167217",2011,"Impact of beta-naphthoflavone on genotoxicity of food-derived carcinogens.","22167217","beta-Naphthoflavone","Cytochrome P-450 CYP1A1"]
["beta-Naphthoflavone","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","22495716",2012,"Activation of aryl hydrocarbon receptor suppresses invasion of esophageal squamous  cell carcinoma cell lines.","22495716","beta-Naphthoflavone","Cytochrome P-450 CYP1A1"]
["beta-Naphthoflavone","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","3671887",1987,"Cytochrome P450-dependent alkoxyphenoxazone dealkylase activities in lung microsomes from untreated and beta-naphthoflavone-treated rats: effect of in vitro inhibitors.","3671887","beta-Naphthoflavone","Cytochrome P-450 CYP1A1"]
["beta-Naphthoflavone","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","7599976",1995,"Inhibition of in vitro aflatoxin B1-DNA binding in rainbow trout by CYP1A inhibitors: alpha-naphthoflavone, beta-naphthoflavone and trout CYP1A1 peptide antibody.","7599976","beta-Naphthoflavone","Cytochrome P-450 CYP1A1"]
["bexarotene","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","11085524",2000,"Induction of adipocyte-specific gene expression is correlated with mammary tumor regression by the retinoid X receptor-ligand LGD1069 (targretin).","11085524","bexarotene","Receptors, Retinoic Acid"]
["bexarotene","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","11479234",2001,"Abrogation of transforming growth factor-alpha/epidermal growth factor receptor autocrine signaling by an RXR-selective retinoid (LGD1069, Targretin) in head and neck cancer cell lines.","11479234","bexarotene","Receptors, Retinoic Acid"]
["bexarotene","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","12443769",2002,"Synthesis of new Targretin analogues that induce apoptosis in leukemia HL-60 cells.","12443769","bexarotene","Receptors, Retinoic Acid"]
["bexarotene","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","12784063",2003,"Effects of oral bexarotene (targretin) on the minimal erythema dose for broadspectrum UVB light.","12784063","bexarotene","Receptors, Retinoic Acid"]
["bexarotene","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","15694016",2005,"Nonclassical retinoids and lung carcinogenesis.","15694016","bexarotene","Receptors, Retinoic Acid"]
["bexarotene","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","17630414",2007,"Subchronic toxicity and toxicogenomic evaluation of tamoxifen citrate + bexarotene in female rats.","17630414","bexarotene","Receptors, Retinoic Acid"]
["bexarotene","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","23395853",2013,"Activation of retinoid receptor-mediated signaling ameliorates diabetes-induced cardiac dysfunction in Zucker diabetic rats.","23395853","bexarotene","Receptors, Retinoic Acid"]
["bexarotene","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","24927566",2014,"Combination of bexarotene and the retinoid CD1530 reduces murine oral-cavity carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide.","24927566","bexarotene","Receptors, Retinoic Acid"]
["bexarotene","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","7583541",1995,"Retinoids stimulate fibrinogen production both in vitro (hepatocytes) and in vivo. Induction requires activation of the retinoid X receptor.","7583541","bexarotene","Receptors, Retinoic Acid"]
["bexarotene","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","8971154",1996,"Chemoprevention of mammary carcinoma by LGD1069 (Targretin): an RXR-selective ligand.","8971154","bexarotene","Receptors, Retinoic Acid"]
["bexarotene","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","9458093",1998,"Beyond tamoxifen: the retinoid X receptor-selective ligand LGD1069 (TARGRETIN) causes complete regression of mammary carcinoma.","9458093","bexarotene","Receptors, Retinoic Acid"]
["bexarotene","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","10779810",2000,"[LGD1069: an antagonist to the X retinoid receptor].","10779810","bexarotene","Receptors, Retinoic Acid"]
["bexarotene","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","11249708",2000,"Bexarotene ligand pharmaceuticals.","11249708","bexarotene","Receptors, Retinoic Acid"]
["bexarotene","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","23925292",2013,"Retinoids activate the irritant receptor TRPV1 and produce sensory hypersensitivity.","23925292","bexarotene","Receptors, Retinoic Acid"]
["bexarotene","retinoic acid receptor gamma_ag","retinoic acid receptor gamma","ag","24927566",2014,"Combination of bexarotene and the retinoid CD1530 reduces murine oral-cavity carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide.","24927566","bexarotene","retinoic acid receptor gamma"]
["bexarotene","Retinoid X Receptor alpha_ag","Retinoid X Receptor alpha","ag","22431924",2012,"Chemopreventive effects of RXR-selective rexinoid bexarotene on intestinal neoplasia of Apc(Min/+) mice.","22431924","bexarotene","Retinoid X Receptor alpha"]
["bexarotene","Retinoid X Receptor alpha_antag","Retinoid X Receptor alpha","antag","25172665",2014,"Rexinoid inhibits Nrf2-mediated transcription through retinoid X receptor alpha.","25172665","bexarotene","Retinoid X Receptor alpha"]
["bexarotene","Retinoid X Receptors_ag","Retinoid X Receptors","ag","11085524",2000,"Induction of adipocyte-specific gene expression is correlated with mammary tumor regression by the retinoid X receptor-ligand LGD1069 (targretin).","11085524","bexarotene","Retinoid X Receptors"]
["bexarotene","Retinoid X Receptors_ag","Retinoid X Receptors","ag","11479234",2001,"Abrogation of transforming growth factor-alpha/epidermal growth factor receptor autocrine signaling by an RXR-selective retinoid (LGD1069, Targretin) in head and neck cancer cell lines.","11479234","bexarotene","Retinoid X Receptors"]
["bexarotene",{"$f":"C515&\"_\"&D515","v":"Retinoid X Receptors_ag"},"Retinoid X Receptors","ag","12443769",2002,"Synthesis of new Targretin analogues that induce apoptosis in leukemia HL-60 cells.","12443769","bexarotene","Retinoid X Receptors"]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  I516,I516)","v":"bexarotene"},"Retinoid X Receptors_ag",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  J516,J516)","v":"Retinoid X Receptors"},"ag",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & H516,H516)","v":"12784063"},2003,"Effects of oral bexarotene (targretin) on the minimal erythema dose for broadspectrum UVB light.","12784063","bexarotene","Retinoid X Receptors"]
["bexarotene","Retinoid X Receptors_ag","Retinoid X Receptors","ag","15663654",2005,"Oral bexarotene in a therapy-resistant Sézary syndrome patient: observations on Sézary cell compartmentalization.","15663654","bexarotene","Retinoid X Receptors"]
["bexarotene","Retinoid X Receptors_ag","Retinoid X Receptors","ag","16245282",2006,"A selective retinoid X receptor agonist bexarotene (LGD1069, Targretin) prevents and overcomes multidrug resistance in advanced prostate cancer.","16245282","bexarotene","Retinoid X Receptors"]
["bexarotene","Retinoid X Receptors_ag","Retinoid X Receptors","ag","16495926",2006,"A selective retinoid X receptor agonist bexarotene (LGD1069, targretin) inhibits angiogenesis and metastasis in solid tumours.","16495926","bexarotene","Retinoid X Receptors"]
["bexarotene","Retinoid X Receptors_ag","Retinoid X Receptors","ag","16829476",2006,"[Central hypothyroidism associated with bexarotene therapy].","16829476","bexarotene","Retinoid X Receptors"]
["bexarotene","Retinoid X Receptors_ag","Retinoid X Receptors","ag","17008586",2006,"The RXR agonist bexarotene improves cholesterol homeostasis and inhibits atherosclerosis progression in a mouse model of mixed dyslipidemia.","17008586","bexarotene","Retinoid X Receptors"]
["bexarotene","Retinoid X Receptors_ag","Retinoid X Receptors","ag","17027148",2007,"The retinoid X receptor-selective ligand, LGD1069, inhibits tumor-induced angiogenesis via suppression of VEGF in human non-small cell lung cancer.","17027148","bexarotene","Retinoid X Receptors"]
["bexarotene","Retinoid X Receptors_ag","Retinoid X Receptors","ag","17204865",2007,"Evidence of myeloid differentiation in non-M3 acute myeloid leukemia treated with the retinoid X receptor agonist bexarotene.","17204865","bexarotene","Retinoid X Receptors"]
["bexarotene","Retinoid X Receptors_ag","Retinoid X Receptors","ag","17440015",2007,"Bexarotene-induced hypothyroidism: bexarotene stimulates the peripheral metabolism of thyroid hormones.","17440015","bexarotene","Retinoid X Receptors"]
["bexarotene","Retinoid X Receptors_ag","Retinoid X Receptors","ag","17483357",2007,"Bexarotene (LGD1069, Targretin), a selective retinoid X receptor agonist, prevents and reverses gemcitabine resistance in NSCLC cells by modulating gene amplification.","17483357","bexarotene","Retinoid X Receptors"]
["bexarotene","Retinoid X Receptors_ag","Retinoid X Receptors","ag","17925686",2007,"[Bexarotene therapy in folliculotropic cutaneous T-cell lymphoma].","17925686","bexarotene","Retinoid X Receptors"]
["bexarotene","Retinoid X Receptors_ag","Retinoid X Receptors","ag","18181037",2008,"Differentiation syndrome in non-M3 acute myeloid leukemia treated with the retinoid X receptor agonist bexarotene.","18181037","bexarotene","Retinoid X Receptors"]
["bexarotene","Retinoid X Receptors_ag","Retinoid X Receptors","ag","18223235",2008,"In vivo and microarray analysis of rexinoid-responsive anaplastic thyroid carcinoma.","18223235","bexarotene","Retinoid X Receptors"]
["bexarotene","Retinoid X Receptors_ag","Retinoid X Receptors","ag","18755147",2008,"RXR agonists inhibit oxidative stress-induced apoptosis in H9c2 rat ventricular cells.","18755147","bexarotene","Retinoid X Receptors"]
["bexarotene","Retinoid X Receptors_ag","Retinoid X Receptors","ag","19138958",2008,"Combination chemoprevention of HER2/neu-induced breast cancer using a cyclooxygenase-2 inhibitor and a retinoid X receptor-selective retinoid.","19138958","bexarotene","Retinoid X Receptors"]
["bexarotene","Retinoid X Receptors_ag","Retinoid X Receptors","ag","19777233",2010,"Bexarotene: a promising anticancer agent.","19777233","bexarotene","Retinoid X Receptors"]
["bexarotene","Retinoid X Receptors_ag","Retinoid X Receptors","ag","19791803",2009,"Modeling, synthesis and biological evaluation of potential retinoid X receptor (RXR) selective agonists: novel analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene).","19791803","bexarotene","Retinoid X Receptors"]
["bexarotene","Retinoid X Receptors_ag","Retinoid X Receptors","ag","21585279",2011,"Successful treatment of angioimmunoblastic T-cell lymphoma with the retinoid X receptor agonist, bexarotene.","21585279","bexarotene","Retinoid X Receptors"]
["bexarotene","Retinoid X Receptors_ag","Retinoid X Receptors","ag","21649908",2011,"In vitro anti-angiogenic properties of LGD1069, a selective retinoid X-receptor agonist through down-regulating Runx2 expression on Human endothelial cells.","21649908","bexarotene","Retinoid X Receptors"]
["bexarotene","Retinoid X Receptors_ag","Retinoid X Receptors","ag","21726055",2011,"Novel silicon-containing analogues of the retinoid agonist bexarotene: syntheses and biological effects on human pluripotent stem cells.","21726055","bexarotene","Retinoid X Receptors"]
["bexarotene","Retinoid X Receptors_ag","Retinoid X Receptors","ag","21920252",2011,"Diffuse idiopathic skeletal hyperostosis associated with bexarotene.","21920252","bexarotene","Retinoid X Receptors"]
["bexarotene","Retinoid X Receptors_ag","Retinoid X Receptors","ag","22223330",2012,"A naturally occurring rexinoid, honokiol, can serve as a regulator of various retinoid x receptor heterodimers.","22223330","bexarotene","Retinoid X Receptors"]
["bexarotene","Retinoid X Receptors_ag","Retinoid X Receptors","ag","22323736",2012,"ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models.","22323736","bexarotene","Retinoid X Receptors"]
["bexarotene","Retinoid X Receptors_ag","Retinoid X Receptors","ag","22873540",2012,"Preclinical success against Alzheimer's disease with an old drug.","22873540","bexarotene","Retinoid X Receptors"]
["bexarotene","Retinoid X Receptors_ag","Retinoid X Receptors","ag","22927238",2012,"Modeling, synthesis and biological evaluation of potential retinoid X receptor-selective agonists: novel halogenated analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene).","22927238","bexarotene","Retinoid X Receptors"]
["bexarotene","Retinoid X Receptors_ag","Retinoid X Receptors","ag","23292798",2013,"Effects on gene expression in rat liver after administration of RXR agonists: UAB30, 4-methyl-UAB30, and Targretin (Bexarotene).","23292798","bexarotene","Retinoid X Receptors"]
["bexarotene","Retinoid X Receptors_ag","Retinoid X Receptors","ag","23395853",2013,"Activation of retinoid receptor-mediated signaling ameliorates diabetes-induced cardiac dysfunction in Zucker diabetic rats.","23395853","bexarotene","Retinoid X Receptors"]
["bexarotene","Retinoid X Receptors_ag","Retinoid X Receptors","ag","24047423",2013,"New hope from an old drug: fighting Alzheimer's disease with the cancer drug bexarotene (targretin)?","24047423","bexarotene","Retinoid X Receptors"]
["bexarotene","Retinoid X Receptors_ag","Retinoid X Receptors","ag","24080207",2013,"Chemopreventive efficacy of raloxifene, bexarotene, and their combination on the progression of chemically induced colon adenomas to adenocarcinomas in rats.","24080207","bexarotene","Retinoid X Receptors"]
["bexarotene","Retinoid X Receptors_ag","Retinoid X Receptors","ag","24333772",2014,"Bexarotene nanocrystal-Oral and parenteral formulation development, characterization and pharmacokinetic evaluation.","24333772","bexarotene","Retinoid X Receptors"]
["bexarotene","Retinoid X Receptors_ag","Retinoid X Receptors","ag","24434091",2013,"The retinoid X receptor agonist bexarotene relieves positive symptoms of schizophrenia: a 6-week, randomized, double-blind, placebo-controlled multicenter trial.","24434091","bexarotene","Retinoid X Receptors"]
["bexarotene","Retinoid X Receptors_ag","Retinoid X Receptors","ag","24666648",2014,"Bexarotene prodrugs: targeting through cleavage by NQO1 (DT-diaphorase).","24666648","bexarotene","Retinoid X Receptors"]
["bexarotene","Retinoid X Receptors_ag","Retinoid X Receptors","ag","24767949",2014,"Bexarotene reduces network excitability in models of Alzheimer's disease and epilepsy.","24767949","bexarotene","Retinoid X Receptors"]
["bexarotene","Retinoid X Receptors_ag","Retinoid X Receptors","ag","24802415",2014,"Protective effects of bexarotene against amyloid-β25-35-induced dysfunction in hippocampal neurons through the insulin signaling pathway.","24802415","bexarotene","Retinoid X Receptors"]
["bexarotene","Retinoid X Receptors_ag","Retinoid X Receptors","ag","25164224",2014,"[Effects and related mechanism of retinoid X receptor agonist bexarotene on atherosclerosis progression in diabetic apoE(-/-) mice].","25164224","bexarotene","Retinoid X Receptors"]
["bexarotene","Retinoid X Receptors_ag","Retinoid X Receptors","ag","25217640",2014,"Amyloid-β pathology and APOE genotype modulate retinoid X receptor agonist activity in vivo.","25217640","bexarotene","Retinoid X Receptors"]
["bexarotene","Retinoid X Receptors_ag","Retinoid X Receptors","ag","26311769",2015,"Bexarotene-Activated Retinoid X Receptors Regulate Neuronal Differentiation and Dendritic Complexity.","26311769","bexarotene","Retinoid X Receptors"]
["bexarotene","Retinoid X Receptors_ag","Retinoid X Receptors","ag","7583541",1995,"Retinoids stimulate fibrinogen production both in vitro (hepatocytes) and in vivo. Induction requires activation of the retinoid X receptor.","7583541","bexarotene","Retinoid X Receptors"]
["bexarotene","Retinoid X Receptors_ag","Retinoid X Receptors","ag","8971154",1996,"Chemoprevention of mammary carcinoma by LGD1069 (Targretin): an RXR-selective ligand.","8971154","bexarotene","Retinoid X Receptors"]
["bexarotene","Retinoid X Receptors_ag","Retinoid X Receptors","ag","9458093",1998,"Beyond tamoxifen: the retinoid X receptor-selective ligand LGD1069 (TARGRETIN) causes complete regression of mammary carcinoma.","9458093","bexarotene","Retinoid X Receptors"]
["bexarotene","Retinoid X Receptors_antag","Retinoid X Receptors","antag","10779810",2000,"[LGD1069: an antagonist to the X retinoid receptor].","10779810","bexarotene","Retinoid X Receptors"]
["bexarotene","Retinoid X Receptors_antag","Retinoid X Receptors","antag","11249708",2000,"Bexarotene ligand pharmaceuticals.","11249708","bexarotene","Retinoid X Receptors"]
["bexarotene","Retinoid X Receptors_antag","Retinoid X Receptors","antag","18765520",2008,"Expanding the use of retinoids in acute myeloid leukemia: spotlight on bexarotene.","18765520","bexarotene","Retinoid X Receptors"]
["bexarotene","Retinoid X Receptors_antag","Retinoid X Receptors","antag","18765556",2008,"A phase I study of bexarotene, a retinoic X receptor agonist, in non-M3 acute myeloid leukemia.","18765556","bexarotene","Retinoid X Receptors"]
["bexarotene-3-(hydroxymethyl)-5-methoxy-1,2-dimethyl-1H-indole-4,7-dione ester","Retinoid X Receptors_ag","Retinoid X Receptors","ag","24666648",2014,"Bexarotene prodrugs: targeting through cleavage by NQO1 (DT-diaphorase).","24666648","bexarotene-3-(hydroxymethyl)-5-methoxy-1,2-dimethyl-1H-indole-4,7-dione ester","Retinoid X Receptors"]
["bigelovin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","21262235",2011,"Structure basis of bigelovin as a selective RXR agonist with a distinct binding mode.","21262235","bigelovin","Retinoid X Receptors"]
["biochanin A","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","12844379",2003,"The red clover (Trifolium pratense) isoflavone biochanin A modulates the biotransformation pathways of 7,12-dimethylbenz[a]anthracene.","12844379","biochanin A","Cytochrome P-450 CYP1A1"]
["biochanin A","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","16903077",2006,"Effect of biochanin A on the aryl hydrocarbon receptor and cytochrome P450 1A1 in MCF-7 human breast carcinoma cells.","16903077","biochanin A","Cytochrome P-450 CYP1A1"]
["bisabolol","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","15936245",2005,"Evaluation of mutagenic and antimutagenic activities of alpha-bisabolol in the Salmonella/microsome assay.","15936245","bisabolol","Cytochrome P-450 CYP1A1"]
["bisphenol A","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","15907334",2005,"Effects of bisphenol A-related diphenylalkanes on vitellogenin production in male carp (Cyprinus carpio) hepatocytes and aromatase (CYP19) activity in human H295R adrenocortical carcinoma cells.","15907334","bisphenol A","Cytochrome P-450 CYP1A1"]
["BMS 189453","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","11158723",2001,"BMS-189453, a novel retinoid receptor antagonist, is a potent testicular toxin.","11158723","BMS 189453","Receptors, Retinoic Acid"]
["BMS 189453","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","12563696",2003,"Inhibition of disease progression by a novel retinoid antagonist in animal models of arthritis.","12563696","BMS 189453","Receptors, Retinoic Acid"]
["BMS 189453","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","16844550",2006,"A multiple retinoic acid antagonist induces conotruncal anomalies, including transposition of the great arteries, in mice.","16844550","BMS 189453","Receptors, Retinoic Acid"]
["BMS 189453","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","21505053",2011,"Oral administration of a retinoic Acid receptor antagonist reversibly inhibits spermatogenesis in mice.","21505053","BMS 189453","Receptors, Retinoic Acid"]
["BMS 649","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","11877083",2001,"[Effects of selective RAR or/and RXR retinoids on the proliferation and differentiation of NB4 cells and their mechanisms].","11877083","BMS 649","Receptors, Retinoic Acid"]
["BMS 649","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","11877083",2001,"[Effects of selective RAR or/and RXR retinoids on the proliferation and differentiation of NB4 cells and their mechanisms].","11877083","BMS 649","retinoic acid receptor alpha"]
["BMS 649","retinoic acid receptor beta_ag","retinoic acid receptor beta","ag","11877083",2001,"[Effects of selective RAR or/and RXR retinoids on the proliferation and differentiation of NB4 cells and their mechanisms].","11877083","BMS 649","retinoic acid receptor beta"]
["BMS 649","Retinoid X Receptors_ag","Retinoid X Receptors","ag","11877083",2001,"[Effects of selective RAR or/and RXR retinoids on the proliferation and differentiation of NB4 cells and their mechanisms].","11877083","BMS 649","Retinoid X Receptors"]
["BMS 961","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","18703560",2008,"Retinoic acid receptor gamma-induced misregulation of chondrogenesis in the murine limb bud in vitro.","18703560","BMS 961","Receptors, Retinoic Acid"]
["BMS 961","retinoic acid receptor gamma_ag","retinoic acid receptor gamma","ag","18703560",2008,"Retinoic acid receptor gamma-induced misregulation of chondrogenesis in the murine limb bud in vitro.","18703560","BMS 961","retinoic acid receptor gamma"]
["BMS453","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","11877083",2001,"[Effects of selective RAR or/and RXR retinoids on the proliferation and differentiation of NB4 cells and their mechanisms].","11877083","BMS453","Receptors, Retinoic Acid"]
["BMS453","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","10573118",1999,"Retinoic acid receptor antagonist BMS453 inhibits the growth of normal and malignant breast cells without activating RAR-dependent gene expression.","10573118","BMS453","Receptors, Retinoic Acid"]
["BMS453","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","11753686",2001,"The retinoic acid receptor antagonist, BMS453, inhibits normal breast cell growth by inducing active TGFbeta and causing cell cycle arrest.","11753686","BMS453","Receptors, Retinoic Acid"]
["BMS453",{"$f":"C579&\"_\"&D579","v":"retinoic acid receptor alpha_ag"},"retinoic acid receptor alpha","ag","11877083",2001,"[Effects of selective RAR or/and RXR retinoids on the proliferation and differentiation of NB4 cells and their mechanisms].","11877083","BMS453","retinoic acid receptor alpha"]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  I580,I580)","v":"BMS453"},"retinoic acid receptor beta_ag",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  J580,J580)","v":"retinoic acid receptor beta"},"ag",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & H580,H580)","v":"11877083"},2001,"[Effects of selective RAR or/and RXR retinoids on the proliferation and differentiation of NB4 cells and their mechanisms].","11877083","BMS453","retinoic acid receptor beta"]
["BMS453","Retinoid X Receptors_ag","Retinoid X Receptors","ag","11877083",2001,"[Effects of selective RAR or/and RXR retinoids on the proliferation and differentiation of NB4 cells and their mechanisms].","11877083","BMS453","Retinoid X Receptors"]
["BMS453","Retinoid X Receptors_antag","Retinoid X Receptors","antag","10573118",1999,"Retinoic acid receptor antagonist BMS453 inhibits the growth of normal and malignant breast cells without activating RAR-dependent gene expression.","10573118","BMS453","Retinoid X Receptors"]
["boldine","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","11265593",2001,"Chemoprotective activity of boldine: modulation of drug-metabolizing enzymes.","11265593","boldine","Cytochrome P-450 CYP1A1"]
["Bortezomib","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","23111325",2012,"Dll1/Notch activation contributes to bortezomib resistance by upregulating CYP1A1 in multiple myeloma.","23111325","Bortezomib","Cytochrome P-450 CYP1A1"]
["butenylisothiocyanate","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","26066520",2015,"The selective cytotoxicity of the alkenyl glucosinolate hydrolysis products and their presence in Brassica vegetables.","26066520","butenylisothiocyanate","Cytochrome P-450 CYP1A1"]
["Butylated Hydroxytoluene","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","18177683",2008,"Mechanisms of butylated hydroxytoluene chemoprevention of aflatoxicosis--inhibition of aflatoxin B1 metabolism.","18177683","Butylated Hydroxytoluene","Cytochrome P-450 CYP1A1"]
["BW 373U86","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","14976126",2004,"Opioid-induced cardioprotection occurs via glycogen synthase kinase beta inhibition during reperfusion in intact rat hearts.","14976126","BW 373U86","Receptors, Retinoic Acid"]
["C.I. Solvent Yellow 56","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","23250514",2013,"Distinct expression patterns and roles of aldehyde dehydrogenases in normal oral mucosa keratinocytes: differential inhibitory effects of a pharmacological inhibitor and RNAi-mediated knockdown on cellular phenotype and epithelial morphology.","23250514","C.I. Solvent Yellow 56","Aldehyde Oxidoreductases"]
["Cadmium","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","26267556",2016,"Cadmium potentiates toxicity of cypermethrin in zebrafish.","26267556","Cadmium","Cytochrome P-450 CYP1A1"]
["Cadmium","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","6677060",1983,"Effect of cadmium in vitro on benzphetamine-N-demethylation and ethoxyresorufin-O-deethylation in rats of different age.","6677060","Cadmium","Cytochrome P-450 CYP1A1"]
["cafestol","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","12804590",2003,"Coffee diterpenes prevent benzo[a]pyrene genotoxicity in rat and human culture systems.","12804590","cafestol","Cytochrome P-450 CYP1A1"]
["Caffeine","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","8095225",1993,"Caffeine, estradiol, and progesterone interact with human CYP1A1 and CYP1A2. Evidence from cDNA-directed expression in Saccharomyces cerevisiae.","8095225","Caffeine","Cytochrome P-450 CYP1A1"]
["calcipotriene","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","16880407",2006,"Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis.","16880407","calcipotriene","Receptors, Retinoic Acid"]
["calcipotriene","retinoic acid receptor gamma_ag","retinoic acid receptor gamma","ag","16880407",2006,"Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis.","16880407","calcipotriene","retinoic acid receptor gamma"]
["calcipotriene","Retinoid X Receptor alpha_ag","Retinoid X Receptor alpha","ag","16880407",2006,"Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis.","16880407","calcipotriene","Retinoid X Receptor alpha"]
["calcipotriene","Retinoid X Receptor beta_ag","Retinoid X Receptor beta","ag","16880407",2006,"Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis.","16880407","calcipotriene","Retinoid X Receptor beta"]
["Calcitriol","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","16880407",2006,"Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis.","16880407","Calcitriol","Receptors, Retinoic Acid"]
["Calcitriol","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","9701451",1998,"Anticoagulant effects of synthetic retinoids and activated vitamin D3.","9701451","Calcitriol","Receptors, Retinoic Acid"]
["Calcitriol","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","12469913",2002,"Inhibition of 1,25-dihydroxyvitamin D3-dependent transcription by synthetic LXXLL peptide antagonists that target the activation domains of the vitamin D and retinoid X receptors.","12469913","Calcitriol","Receptors, Retinoic Acid"]
["Calcitriol","retinoic acid receptor gamma_ag","retinoic acid receptor gamma","ag","16880407",2006,"Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis.","16880407","Calcitriol","retinoic acid receptor gamma"]
["Calcitriol","Retinoid X Receptor alpha_ag","Retinoid X Receptor alpha","ag","16880407",2006,"Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis.","16880407","Calcitriol","Retinoid X Receptor alpha"]
["Calcitriol","Retinoid X Receptor alpha_antag","Retinoid X Receptor alpha","antag","17595320",2007,"Insulin-like growth factor binding protein-5 interacts with the vitamin D receptor and modulates the vitamin D response in osteoblasts.","17595320","Calcitriol","Retinoid X Receptor alpha"]
["Calcitriol","Retinoid X Receptor beta_ag","Retinoid X Receptor beta","ag","16880407",2006,"Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis.","16880407","Calcitriol","Retinoid X Receptor beta"]
["Calcitriol","Retinoid X Receptors_ag","Retinoid X Receptors","ag","9701451",1998,"Anticoagulant effects of synthetic retinoids and activated vitamin D3.","9701451","Calcitriol","Retinoid X Receptors"]
["Calcitriol","Retinoid X Receptors_antag","Retinoid X Receptors","antag","12469913",2002,"Inhibition of 1,25-dihydroxyvitamin D3-dependent transcription by synthetic LXXLL peptide antagonists that target the activation domains of the vitamin D and retinoid X receptors.","12469913","Calcitriol","Retinoid X Receptors"]
["Calcium","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","6634825",1983,"Effects of magnesium and calcium on mitochondrial and cytosolic liver aldehyde dehydrogenases.","6634825","Calcium","Aldehyde Oxidoreductases"]
["Calcium","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","7138510",1982,"Effects of Mg2+, Ca2+ and Mn2+ on sheep liver cytoplasmic aldehyde dehydrogenase.","7138510","Calcium","Aldehyde Oxidoreductases"]
["Calcium","Secretin_antag","Secretin","antag","443428",1979,"Effect of extracellular calcium on amylase release from dispersed pancreatic acini.","443428","Calcium","Secretin"]
["Cannabidiol","CYP1A1 protein, human_antag","CYP1A1 protein, human","antag","23811569",2013,"Structural requirements for potent direct inhibition of human cytochrome P450 1A1 by cannabidiol: role of pentylresorcinol moiety.","23811569","Cannabidiol","CYP1A1 protein, human"]
["Cannabidiol","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","23811569",2013,"Structural requirements for potent direct inhibition of human cytochrome P450 1A1 by cannabidiol: role of pentylresorcinol moiety.","23811569","Cannabidiol","Cytochrome P-450 CYP1A1"]
["Cannabidiol","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","24667653",2014,"Characterization of the structural determinants required for potent mechanism-based inhibition of human cytochrome P450 1A1 by cannabidiol.","24667653","Cannabidiol","Cytochrome P-450 CYP1A1"]
["Capsaicin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","21250977",2011,"CCAAT/ enhancer-binding protein β activation by capsaicin contributes to the regulation of CYP1A1 expression, mediated by the aryl hydrocarbon receptor.","21250977","Capsaicin","Cytochrome P-450 CYP1A1"]
["Capsaicin","Secretin_antag","Secretin","antag","9655680",1998,"Secretin inhibits gastric acid secretion via a vagal afferent pathway in rats.","9655680","Capsaicin","Secretin"]
["Carbamazepine","CYP1A1 protein, human_antag","CYP1A1 protein, human","antag","24352538",2014,"Inhibition of tumour spheroid-induced prometastatic intravasation gates in the lymph endothelial cell barrier by carbamazepine: drug testing in a 3D model.","24352538","Carbamazepine","CYP1A1 protein, human"]
["Carbamazepine","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","24352538",2014,"Inhibition of tumour spheroid-induced prometastatic intravasation gates in the lymph endothelial cell barrier by carbamazepine: drug testing in a 3D model.","24352538","Carbamazepine","Cytochrome P-450 CYP1A1"]
["carbazole","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","21506276",2011,"Design and stereoselective synthesis of retinoids with ferrocene or N-butylcarbazole pharmacophores that induce post-differentiation apoptosis in acute promyelocytic leukemia cells.","21506276","carbazole","Receptors, Retinoic Acid"]
["carbazole","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","21506276",2011,"Design and stereoselective synthesis of retinoids with ferrocene or N-butylcarbazole pharmacophores that induce post-differentiation apoptosis in acute promyelocytic leukemia cells.","21506276","carbazole","retinoic acid receptor alpha"]
["Carbon Disulfide","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","1262067",1976,"Blood acetaldehyde in alcoholized rats and humans during inhalation of carbon disulphide vapor.","1262067","Carbon Disulfide","Aldehyde Oxidoreductases"]
["Carbon Disulfide","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","8068656",1994,"Binding of carbon disulfide to the site of acetyl-CoA synthesis by the nickel-iron-sulfur protein, carbon monoxide dehydrogenase, from Clostridium thermoaceticum.","8068656","Carbon Disulfide","Aldehyde Oxidoreductases"]
["Carbon Monoxide","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","23368960",2013,"A unified electrocatalytic description of the action of inhibitors of nickel carbon monoxide dehydrogenase.","23368960","Carbon Monoxide","Aldehyde Oxidoreductases"]
["Carbon Tetrachloride","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","6836571",1983,"Time course of the carbon tetrachloride-induced decrease in mitochondrial aldehyde dehydrogenase activity.","6836571","Carbon Tetrachloride","Aldehyde Oxidoreductases"]
["Carbon Tetrachloride","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","7256753",1981,"Decreased in vivo acetaldehyde oxidation and hepatic aldehyde dehydrogenase inhibition in C57BL and DBA mice treated with carbon tetrachloride.","7256753","Carbon Tetrachloride","Aldehyde Oxidoreductases"]
["Carbon Tetrachloride","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","7299699",1981,"Inhibition of rat liver aldehyde dehydrogenase by carbon tetrachloride.","7299699","Carbon Tetrachloride","Aldehyde Oxidoreductases"]
["Carbon Tetrachloride","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","8130776",1993,"Inhibition of the induction and activity of hepatic P450IA isozymes by in vivo administration of carbon tetrachloride to rats.","8130776","Carbon Tetrachloride","Cytochrome P-450 CYP1A1"]
["carbonyl sulfide","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","2510818",1989,"Carbonyl sulfide inhibition of CO dehydrogenase from Rhodospirillum rubrum.","2510818","carbonyl sulfide","Aldehyde Oxidoreductases"]
["carboprostacyclin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","11708867",2001,"Limited cooperation between peroxisome proliferator-activated receptors and retinoid X receptor agonists in sebocyte growth and development.","11708867","carboprostacyclin","Receptors, Retinoic Acid"]
["carboprostacyclin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","11708867",2001,"Limited cooperation between peroxisome proliferator-activated receptors and retinoid X receptor agonists in sebocyte growth and development.","11708867","carboprostacyclin","Retinoid X Receptors"]
["Carmine","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","12379470",2002,"Inhibition of human cytochrome P450 1B1, 1A1 and 1A2 by antigenotoxic compounds, purpurin and alizarin.","12379470","Carmine","Cytochrome P-450 CYP1A1"]
["Catechin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","12670496",2003,"In vitro assessment of inhibition by natural polyphenols of metabolic activation of procarcinogens by human CYP1A1.","12670496","Catechin","Cytochrome P-450 CYP1A1"]
["CD 2019","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","10663386",2000,"Selective agonists of retinoic acid receptors: comparative toxicokinetics and embryonic exposure.","10663386","CD 2019","Receptors, Retinoic Acid"]
["CD 2019","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","11726401",2001,"Effects of retinoic acid receptor-selective agonists on human nasal epithelial cell differentiation.","11726401","CD 2019","Receptors, Retinoic Acid"]
["CD 2019","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","11726401",2001,"Effects of retinoic acid receptor-selective agonists on human nasal epithelial cell differentiation.","11726401","CD 2019","retinoic acid receptor alpha"]
["CD 2019","retinoic acid receptor beta_ag","retinoic acid receptor beta","ag","11726401",2001,"Effects of retinoic acid receptor-selective agonists on human nasal epithelial cell differentiation.","11726401","CD 2019","retinoic acid receptor beta"]
["CD 2019","retinoic acid receptor gamma_ag","retinoic acid receptor gamma","ag","11726401",2001,"Effects of retinoic acid receptor-selective agonists on human nasal epithelial cell differentiation.","11726401","CD 2019","retinoic acid receptor gamma"]
["CD 3254","Retinoid X Receptors_ag","Retinoid X Receptors","ag","24180745",2013,"Modeling, synthesis, and biological evaluation of potential retinoid X receptor (RXR) selective agonists: novel analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene) and (E)-3-(3-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)-4-hydroxyphenyl)acrylic acid (CD3254).","24180745","CD 3254","Retinoid X Receptors"]
["CD 437","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","10374844",1999,"The RARgamma selective agonist CD437 inhibits gastric cell growth through the mechanism of apoptosis.","10374844","CD 437","Receptors, Retinoic Acid"]
["CD 437","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","10626821",1999,"The novel retinoid 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphtalene carboxylic acid can trigger apoptosis through a mitochondrial pathway independent of the nucleus.","10626821","CD 437","Receptors, Retinoic Acid"]
["CD 437","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","10663386",2000,"Selective agonists of retinoic acid receptors: comparative toxicokinetics and embryonic exposure.","10663386","CD 437","Receptors, Retinoic Acid"]
["CD 437","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","11141350",2001,"Synergistic teratogenic effects induced by retinoids in mice by coadministration of a RARalpha- or RARgamma-selective agonist with a RXR-selective agonist.","11141350","CD 437","Receptors, Retinoic Acid"]
["CD 437","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","14991612",2004,"Retinoids induce Fas(CD95) ligand cell surface expression via RARgamma and nur77 in T cells.","14991612","CD 437","Receptors, Retinoic Acid"]
["CD 437","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","9920855",1999,"The novel synthetic retinoid 6-[3-adamantyl-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437) causes apoptosis in acute promyelocytic leukemia cells through rapid activation of caspases.","9920855","CD 437","Receptors, Retinoic Acid"]
["CD 437","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","10953043",2000,"Dual mechanisms of action of the retinoid CD437: nuclear retinoic acid receptor-mediated suppression of squamous differentiation and receptor-independent induction of apoptosis in UMSCC22B human head and neck squamous cell carcinoma cells.","10953043","CD 437","Receptors, Retinoic Acid"]
["CD 437",{"$f":"C643&\"_\"&D643","v":"Receptors, Retinoic Acid_antag"},"Receptors, Retinoic Acid","antag","11423908",2001,"Evidence of a lysosomal pathway for apoptosis induced by the synthetic retinoid CD437 in human leukemia HL-60 cells.","11423908","CD 437","Receptors, Retinoic Acid"]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  I644,I644)","v":"CD 437"},"Receptors, Retinoic Acid_antag",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  J644,J644)","v":"Receptors, Retinoic Acid"},"antag",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & H644,H644)","v":"9365537"},1997,"Induction of apoptosis in human non-small cell lung carcinoma cells by the novel synthetic retinoid CD437.","9365537","CD 437","Receptors, Retinoic Acid"]
["CD 437","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","11141350",2001,"Synergistic teratogenic effects induced by retinoids in mice by coadministration of a RARalpha- or RARgamma-selective agonist with a RXR-selective agonist.","11141350","CD 437","retinoic acid receptor alpha"]
["CD 437","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","9920855",1999,"The novel synthetic retinoid 6-[3-adamantyl-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437) causes apoptosis in acute promyelocytic leukemia cells through rapid activation of caspases.","9920855","CD 437","retinoic acid receptor alpha"]
["CD 437","retinoic acid receptor gamma_ag","retinoic acid receptor gamma","ag","10374844",1999,"The RARgamma selective agonist CD437 inhibits gastric cell growth through the mechanism of apoptosis.","10374844","CD 437","retinoic acid receptor gamma"]
["CD 437","retinoic acid receptor gamma_ag","retinoic acid receptor gamma","ag","10626821",1999,"The novel retinoid 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphtalene carboxylic acid can trigger apoptosis through a mitochondrial pathway independent of the nucleus.","10626821","CD 437","retinoic acid receptor gamma"]
["CD 437","retinoic acid receptor gamma_ag","retinoic acid receptor gamma","ag","11141350",2001,"Synergistic teratogenic effects induced by retinoids in mice by coadministration of a RARalpha- or RARgamma-selective agonist with a RXR-selective agonist.","11141350","CD 437","retinoic acid receptor gamma"]
["CD 437","retinoic acid receptor gamma_ag","retinoic acid receptor gamma","ag","14991612",2004,"Retinoids induce Fas(CD95) ligand cell surface expression via RARgamma and nur77 in T cells.","14991612","CD 437","retinoic acid receptor gamma"]
["CD 437","retinoic acid receptor gamma_ag","retinoic acid receptor gamma","ag","9920855",1999,"The novel synthetic retinoid 6-[3-adamantyl-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437) causes apoptosis in acute promyelocytic leukemia cells through rapid activation of caspases.","9920855","CD 437","retinoic acid receptor gamma"]
["CD 437","Retinoid X Receptors_ag","Retinoid X Receptors","ag","11141350",2001,"Synergistic teratogenic effects induced by retinoids in mice by coadministration of a RARalpha- or RARgamma-selective agonist with a RXR-selective agonist.","11141350","CD 437","Retinoid X Receptors"]
["CD 437","Retinoid X Receptors_ag","Retinoid X Receptors","ag","14991612",2004,"Retinoids induce Fas(CD95) ligand cell surface expression via RARgamma and nur77 in T cells.","14991612","CD 437","Retinoid X Receptors"]
["CD 666","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","11726401",2001,"Effects of retinoic acid receptor-selective agonists on human nasal epithelial cell differentiation.","11726401","CD 666","Receptors, Retinoic Acid"]
["CD 666","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","11726401",2001,"Effects of retinoic acid receptor-selective agonists on human nasal epithelial cell differentiation.","11726401","CD 666","retinoic acid receptor alpha"]
["CD 666","retinoic acid receptor beta_ag","retinoic acid receptor beta","ag","11726401",2001,"Effects of retinoic acid receptor-selective agonists on human nasal epithelial cell differentiation.","11726401","CD 666","retinoic acid receptor beta"]
["CD 666","retinoic acid receptor gamma_ag","retinoic acid receptor gamma","ag","11726401",2001,"Effects of retinoic acid receptor-selective agonists on human nasal epithelial cell differentiation.","11726401","CD 666","retinoic acid receptor gamma"]
["CD2665","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","9365537",1997,"Induction of apoptosis in human non-small cell lung carcinoma cells by the novel synthetic retinoid CD437.","9365537","CD2665","Receptors, Retinoic Acid"]
["Celecoxib","Retinoid X Receptors_ag","Retinoid X Receptors","ag","19138958",2008,"Combination chemoprevention of HER2/neu-induced breast cancer using a cyclooxygenase-2 inhibitor and a retinoid X receptor-selective retinoid.","19138958","Celecoxib","Retinoid X Receptors"]
["Cerulenin","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","2738025",1989,"Inhibition of Vibrio harveyi bioluminescence by cerulenin: in vivo evidence for covalent modification of the reductase enzyme involved in aldehyde synthesis.","2738025","Cerulenin","Aldehyde Oxidoreductases"]
["Cerulenin","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","2751874",1989,"Covalent reaction of cerulenin at the active site of acyl-CoA reductase of Photobacterium phosphoreum.","2751874","Cerulenin","Aldehyde Oxidoreductases"]
["Chalcone","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","12499122",2003,"A study on CYP1A inhibitory action of E-2-(4'-methoxybenzylidene)-1-benzosuberone and some related chalcones and cyclic chalcone analogues.","12499122","Chalcone","Cytochrome P-450 CYP1A1"]
["Chalcone","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","15596260",2005,"Hydroxychalcones exhibit differential effects on XRE transactivation.","15596260","Chalcone","Cytochrome P-450 CYP1A1"]
["chelerythrine","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","16115718",2006,"Investigation of sanguinarine and chelerythrine effects on CYP1A1 expression and activity in human hepatoma cells.","16115718","chelerythrine","Cytochrome P-450 CYP1A1"]
["Chitosan","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","20828325",2010,"Effects of chitooligosaccharide lactate salt on activity of acetaldehyde dehydrogenase.","20828325","Chitosan","Aldehyde Oxidoreductases"]
["Chloral Hydrate","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","7163339",1982,"Reversible inhibitors of aldehyde dehydrogenase.","7163339","Chloral Hydrate","Aldehyde Oxidoreductases"]
["Chlorambucil","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","21684744",2011,"A transcription factor hijacking to regulate RARα by using a chimeric molecule of retinoic acid and a DNA alkylator.","21684744","Chlorambucil","Receptors, Retinoic Acid"]
["Chlorambucil","retinoic acid receptor alpha_antag","retinoic acid receptor alpha","antag","21684744",2011,"A transcription factor hijacking to regulate RARα by using a chimeric molecule of retinoic acid and a DNA alkylator.","21684744","Chlorambucil","retinoic acid receptor alpha"]
["chloramine","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","8461035",1993,"Inhibitory action of chloramine on formate-metabolizing system. Studies suggested by an unusual case record.","8461035","chloramine","Aldehyde Oxidoreductases"]
["chlorophyllin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","7518046",1994,"Mechanisms of the in vitro antimutagenic action of chlorophyllin against benzo[a]pyrene: studies of enzyme inhibition, molecular complex formation and degradation of the ultimate carcinogen.","7518046","chlorophyllin","Cytochrome P-450 CYP1A1"]
["Chloroquine","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","24659340",2014,"Comparative study of autophagy inhibition by 3MA and CQ  on Cytarabine‑induced death of leukaemia cells.","24659340","Chloroquine","Receptors, Retinoic Acid"]
["Chloroquine","retinoic acid receptor alpha_antag","retinoic acid receptor alpha","antag","24659340",2014,"Comparative study of autophagy inhibition by 3MA and CQ  on Cytarabine‑induced death of leukaemia cells.","24659340","Chloroquine","retinoic acid receptor alpha"]
["Chlorphenamidine","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","520804",1979,"Inhibition of ethanol and acetate metabolism in mice by chlordimeform and related compounds.","520804","Chlorphenamidine","Aldehyde Oxidoreductases"]
["Chlorpromazine","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","1417944",1992,"Inhibition and induction of cytochrome P450 2B1 in rat liver by promazine and chlorpromazine.","1417944","Chlorpromazine","Cytochrome P-450 CYP1A1"]
["Cholecalciferol","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","9952315",1999,"Greater synergism of retinoic acid receptor (RAR) agonists with vitamin D3 than that of retinoid X receptor (RXR) agonists with regard to growth inhibition and differentiation induction in monoblastic leukemia cells.","9952315","Cholecalciferol","Receptors, Retinoic Acid"]
["Cholecalciferol","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","9952315",1999,"Greater synergism of retinoic acid receptor (RAR) agonists with vitamin D3 than that of retinoid X receptor (RXR) agonists with regard to growth inhibition and differentiation induction in monoblastic leukemia cells.","9952315","Cholecalciferol","Receptors, Retinoic Acid"]
["Cholecalciferol","Retinoid X Receptors_ag","Retinoid X Receptors","ag","9952315",1999,"Greater synergism of retinoic acid receptor (RAR) agonists with vitamin D3 than that of retinoid X receptor (RXR) agonists with regard to growth inhibition and differentiation induction in monoblastic leukemia cells.","9952315","Cholecalciferol","Retinoid X Receptors"]
["Cholecalciferol","Retinoid X Receptors_antag","Retinoid X Receptors","antag","9952315",1999,"Greater synergism of retinoic acid receptor (RAR) agonists with vitamin D3 than that of retinoid X receptor (RXR) agonists with regard to growth inhibition and differentiation induction in monoblastic leukemia cells.","9952315","Cholecalciferol","Retinoid X Receptors"]
["Cholesterol","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","11684682",2002,"Sterol regulatory element-binding protein-1c is responsible for cholesterol regulation of ileal bile acid-binding protein gene in vivo. Possible involvement of liver-X-receptor.","11684682","Cholesterol","Receptors, Retinoic Acid"]
["Cholesterol","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","15147902",2004,"ADP-ribosylation factor (ARF)-like 7 (ARL7) is induced by cholesterol loading and participates in apolipoprotein AI-dependent cholesterol export.","15147902","Cholesterol","Receptors, Retinoic Acid"]
["Cholesterol","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","11371634",2001,"Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR.","11371634","Cholesterol","Receptors, Retinoic Acid"]
["Cholesterol","retinol-palmitate esterase_antag","retinol-palmitate esterase","antag","6743674",1984,"Inhibition of rat liver retinyl palmitate hydrolase activity by ether analogs of cholesteryl esters and acylglycerides.","6743674","Cholesterol","retinol-palmitate esterase"]
["chrysin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","11752233",2002,"Flavonoids inhibit genetic toxicity produced by carcinogens in cells expressing CYP1A2 and CYP1A1.","11752233","chrysin","Cytochrome P-450 CYP1A1"]
["chrysin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","16276964",2005,"Effects of hydroxyl group numbers on the B-ring of 5,7-dihydroxyflavones on the differential inhibition of human CYP 1A and CYP1B1 enzymes.","16276964","chrysin","Cytochrome P-450 CYP1A1"]
["chrysin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","17093006",2007,"Effects of the flavonoid chrysin on nitrofurantoin pharmacokinetics in rats: potential involvement of ABCG2.","17093006","chrysin","Cytochrome P-450 CYP1A1"]
["chrysin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","19766177",2009,"CYP1A1 and CYP3A4 modulation by dietary flavonoids in human intestinal Caco-2 cells.","19766177","chrysin","Cytochrome P-450 CYP1A1"]
["chrysoeriol","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","19833205",2010,"A methoxyflavonoid, chrysoeriol, selectively inhibits the formation of a carcinogenic estrogen metabolite in MCF-7 breast cancer cells.","19833205","chrysoeriol","Cytochrome P-450 CYP1A1"]
["Cibacron Blue F 3GA","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","3170510",1988,"Interaction of 4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase with Reactive Blue 2 and related dyes.","3170510","Cibacron Blue F 3GA","Aldehyde Oxidoreductases"]
["ciglitazone","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","11728177",2001,"Stimulated release of arachidonic acid by agonists of the peroxisome proliferator-activated receptor and retinoic acid receptors.","11728177","ciglitazone","Receptors, Retinoic Acid"]
["ciglitazone","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","12006550",2002,"Nuclear receptor agonists as potential differentiation therapy agents for human osteosarcoma.","12006550","ciglitazone","Receptors, Retinoic Acid"]
["ciglitazone","Retinoid X Receptors_ag","Retinoid X Receptors","ag","12006550",2002,"Nuclear receptor agonists as potential differentiation therapy agents for human osteosarcoma.","12006550","ciglitazone","Retinoid X Receptors"]
["ciglitazone","Retinoid X Receptors_ag","Retinoid X Receptors","ag","18571164",2009,"Peroxisome proliferator-activated receptor-gamma and retinoid X receptor agonists synergistically suppress proliferation of immortalized endometrial stromal cells.","18571164","ciglitazone","Retinoid X Receptors"]
["ciglitazone","Retinoid X Receptors_ag","Retinoid X Receptors","ag","19288012",2009,"Enhanced effects of PPARgamma ligands and RXR selective retinoids in combination to inhibit migration and invasiveness in cancer cells.","19288012","ciglitazone","Retinoid X Receptors"]
["Cimetidine","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","3087288",1986,"Evidence for induction of hepatic microsomal cytochrome P-450 by cimetidine: binding and kinetic studies.","3087288","Cimetidine","Cytochrome P-450 CYP1A1"]
["Cimetidine","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","9454789",1998,"In vivo cimetidine inhibits hepatic CYP2C6 and CYP2C11 but not CYP1A1 in adult male rats.","9454789","Cimetidine","Cytochrome P-450 CYP1A1"]
["Ciprofloxacin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","21787699",2011,"Effects of cytochrome P450 1A substrate (difloxacin) on enzyme gene expression and pharmacokinetics in crucian carp (hybridized Prussian carp).","21787699","Ciprofloxacin","Cytochrome P-450 CYP1A1"]
["cirsiliol","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","19601638",2009,"The methoxylated flavones eupatorin and cirsiliol induce CYP1 enzyme expression in MCF7 cells.","19601638","cirsiliol","Cytochrome P-450 CYP1A1"]
["citral","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","10712624",2000,"Light-adaptive effects of retinoic acid on receptive field properties of retinal horizontal cells.","10712624","citral","Aldehyde Oxidoreductases"]
["citral","Retinal Dehydrogenase_antag","Retinal Dehydrogenase","antag","10712624",2000,"Light-adaptive effects of retinoic acid on receptive field properties of retinal horizontal cells.","10712624","citral","Retinal Dehydrogenase"]
["Clofibrate","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","12680773",2003,"Reduction of all-trans-retinal in the mouse liver peroxisome fraction by the short-chain dehydrogenase/reductase RRD: induction by the PPAR alpha ligand clofibrate.","12680773","Clofibrate","Aldehyde Oxidoreductases"]
["Clofibrate","Retinal Dehydrogenase_antag","Retinal Dehydrogenase","antag","12680773",2003,"Reduction of all-trans-retinal in the mouse liver peroxisome fraction by the short-chain dehydrogenase/reductase RRD: induction by the PPAR alpha ligand clofibrate.","12680773","Clofibrate","Retinal Dehydrogenase"]
["Clofibric Acid","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","18406567",2008,"Effects of fibrates, anti-inflammatory drugs and antidepressants in the fish hepatoma cell line PLHC-1: cytotoxicity and interactions with cytochrome P450 1A.","18406567","Clofibric Acid","Cytochrome P-450 CYP1A1"]
["Clotrimazole","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","10190046",1999,"Noncompetitive mixed-type inhibition of rainbow trout CYP1A catalytic activity by clotrimazole.","10190046","Clotrimazole","Cytochrome P-450 CYP1A1"]
["Clotrimazole","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","23466084",2013,"Clotrimazole, but not dexamethasone, is a potent in vitro inhibitor of cytochrome P450 isoforms CYP1A and CYP3A in rainbow trout.","23466084","Clotrimazole","Cytochrome P-450 CYP1A1"]
["Clotrimazole","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","3263862",1988,"Inhibition of human hepatic and placental xenobiotic monooxygenases by imidazole antimycotics.","3263862","Clotrimazole","Cytochrome P-450 CYP1A1"]
["Clozapine","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","9690983",1998,"Effect of fluoxetine on the plasma concentrations of clozapine and its major metabolites in patients with schizophrenia.","9690983","Clozapine","Cytochrome P-450 CYP1A1"]
["coenzyme Q10",{"$f":"C707&\"_\"&D707","v":"retinoid isomerohydrolase_antag"},"retinoid isomerohydrolase","antag","22843363",2012,"Coenzyme Q10 protects retinal cells from apoptosis induced by radiation in vitro and in vivo.","22843363","coenzyme Q10","retinoid isomerohydrolase"]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  I708,I708)","v":"Copper Sulfate"},"Cytochrome P-450 CYP1A1_antag",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  J708,J708)","v":"Cytochrome P-450 CYP1A1"},"antag",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & H708,H708)","v":"18439880"},2008,"Effects of Cu(2+) and Pb(2+) on different fish species: liver cytochrome P450-dependent monooxygenase activities and FTIR spectra.","18439880","Copper Sulfate","Cytochrome P-450 CYP1A1"]
["coriandrin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","8831817",1996,"Mechanism-based inactivation of hepatic ethoxyresorufin O-dealkylation activity by naturally occurring coumarins.","8831817","coriandrin","Cytochrome P-450 CYP1A1"]
["coumarin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","2032655",1991,"Coumarin-induced changes in delta-aminolaevulinic acid synthase and cytochrome P-450 in chick embryo liver.","2032655","coumarin","Cytochrome P-450 CYP1A1"]
["Creosote","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","15178029",2004,"Teratogenesis in Fundulus heteroclitus embryos exposed to a creosote-contaminated sediment extract and CYP1A inhibitors.","15178029","Creosote","Cytochrome P-450 CYP1A1"]
["Curcumin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","11346483",2001,"Inhibition of cytochrome P450 isozymes by curcumins in vitro and in vivo.","11346483","Curcumin","Cytochrome P-450 CYP1A1"]
["Curcumin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","12359752",2002,"Curcumin activates the aryl hydrocarbon receptor yet significantly inhibits (-)-benzo(a)pyrene-7R-trans-7,8-dihydrodiol bioactivation in oral squamous cell carcinoma cells and oral mucosa.","12359752","Curcumin","Cytochrome P-450 CYP1A1"]
["Curcumin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","22867086",2012,"Quercetin, resveratrol, and curcumin are indirect activators of the aryl hydrocarbon receptor (AHR).","22867086","Curcumin","Cytochrome P-450 CYP1A1"]
["Curcumin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","8534266",1996,"Effects of curcumin on cytochrome P450 and glutathione S-transferase activities in rat liver.","8534266","Curcumin","Cytochrome P-450 CYP1A1"]
["Cyanamide","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","3089300",1986,"Inhibition of CO2 production from aminopyrine or methanol by cyanamide or crotonaldehyde and the role of mitochondrial aldehyde dehydrogenase in formaldehyde oxidation.","3089300","Cyanamide","Aldehyde Oxidoreductases"]
["Cyanamide","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","6378202",1984,"The metabolic activation of cyanamide to an inhibitor of aldehyde dehydrogenase is catalyzed by catalase.","6378202","Cyanamide","Aldehyde Oxidoreductases"]
["Cyanamide","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","6634840",1983,"Metabolic activation of cyanamide to an inhibitor of aldehyde dehydrogenase in vitro.","6634840","Cyanamide","Aldehyde Oxidoreductases"]
["Cyanamide","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","6640426",1983,"Inhibition of hepatic aldehyde dehydrogenases in the rat by calcium carbimide (calcium cyanamide).","6640426","Cyanamide","Aldehyde Oxidoreductases"]
["Cyanamide","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","6733600",1984,"Decrease in calcium carbimide (calcium cyanamide)-induced inhibition of rat hepatic aldehyde dehydrogenases by multiple ethanol administration.","6733600","Cyanamide","Aldehyde Oxidoreductases"]
["Cyanamide","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","6753841",1982,"Metabolic activation of cyanamide by liver mitochondria, a requirement for the inhibition of aldehyde dehydrogenase enzymes.","6753841","Cyanamide","Aldehyde Oxidoreductases"]
["Cyanamide","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","6861004",1983,"Specificity of hepatic aldehyde dehydrogenase inhibition by calcium carbimide (calcium cyanamide) in the rat.","6861004","Cyanamide","Aldehyde Oxidoreductases"]
["Cyanamide","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","6870943",1983,"Studies in vitro on the inactivation of mitochondrial rat-liver aldehyde dehydrogenase by the alcohol-sensitizing compounds cyanamide, 1-aminocyclopropanol and disulfiram.","6870943","Cyanamide","Aldehyde Oxidoreductases"]
["Cyanamide","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","7013545",1981,"The effect of cyanamide on acetaldehyde oxidation by isolated rat liver mitochondria and on the inhibition of pyruvate oxidation by acetaldehyde.","7013545","Cyanamide","Aldehyde Oxidoreductases"]
["Cyanamide","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","7028794",1981,"A comparative review of the pharmacological and toxicological properties of disulfiram and calcium carbimide.","7028794","Cyanamide","Aldehyde Oxidoreductases"]
["Cyanamide","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","7038717",1981,"The disulfiram and calcium carbimide acetaldehyde-mediated ethanol reactions.","7038717","Cyanamide","Aldehyde Oxidoreductases"]
["Cyanamide","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","7115421",1982,"Studies on the cyanamide-ethanol interaction. Dimethylcyanamide as an inhibitor of aldehyde dehydrogenase in vivo.","7115421","Cyanamide","Aldehyde Oxidoreductases"]
["Cyanamide","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","7295327",1981,"Inhibition by cyanamide of 4-hydroxycyclophosphamide/aldophosphamide oxidation to carboxyphosphamide.","7295327","Cyanamide","Aldehyde Oxidoreductases"]
["Cyanamide","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","7428804",1980,"Intraindividual variability in the calcium carbimide-ethanol interaction.","7428804","Cyanamide","Aldehyde Oxidoreductases"]
["Cyclic AMP","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","9351827",1997,"Phosphorylation of activation functions AF-1 and AF-2 of RAR alpha and RAR gamma is indispensable for differentiation of F9 cells upon retinoic acid and cAMP treatment.","9351827","Cyclic AMP","Receptors, Retinoic Acid"]
["Cyclic AMP","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","9351827",1997,"Phosphorylation of activation functions AF-1 and AF-2 of RAR alpha and RAR gamma is indispensable for differentiation of F9 cells upon retinoic acid and cAMP treatment.","9351827","Cyclic AMP","retinoic acid receptor alpha"]
["Cyclic AMP","retinoic acid receptor gamma_ag","retinoic acid receptor gamma","ag","9351827",1997,"Phosphorylation of activation functions AF-1 and AF-2 of RAR alpha and RAR gamma is indispensable for differentiation of F9 cells upon retinoic acid and cAMP treatment.","9351827","Cyclic AMP","retinoic acid receptor gamma"]
["Cyclophosphamide","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","179712",1976,"Studies on the selective action of cyclophosphamide (NSC-26271): Inactivation of the hydroxylated metabolite by tissue-soluble enzymes.","179712","Cyclophosphamide","Aldehyde Oxidoreductases"]
["Cyclophosphamide","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","6732847",1984,"Deoxyribonucleic acid crosslinking by 4-hydroperoxycyclophosphamide in cyclophosphamide-sensitive and -resistant L1210 cells.","6732847","Cyclophosphamide","Aldehyde Oxidoreductases"]
["Cyclophosphamide","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","7365745",1980,"Cyclophosphamide potentiation and aldehyde oxidase inhibition by phosphorylated aldehydes and acetals.","7365745","Cyclophosphamide","Aldehyde Oxidoreductases"]
["Cytarabine","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","24659340",2014,"Comparative study of autophagy inhibition by 3MA and CQ  on Cytarabine‑induced death of leukaemia cells.","24659340","Cytarabine","Receptors, Retinoic Acid"]
["Cytarabine","retinoic acid receptor alpha_antag","retinoic acid receptor alpha","antag","24659340",2014,"Comparative study of autophagy inhibition by 3MA and CQ  on Cytarabine‑induced death of leukaemia cells.","24659340","Cytarabine","retinoic acid receptor alpha"]
["Dacarbazine","Retinoblastoma-Binding Protein 2_antag","Retinoblastoma-Binding Protein 2","antag","26566863",2015,"The histone demethylase KDM5A is a key factor for the resistance to temozolomide in glioblastoma.","26566863","Dacarbazine","Retinoblastoma-Binding Protein 2"]
["daidzein","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","10597900",1999,"Inhibition of CYP1A1 enzyme activity in mouse hepatoma cell culture by soybean isoflavones.","10597900","daidzein","Cytochrome P-450 CYP1A1"]
["daidzein","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","15479032",2004,"Inhibition of extrahepatic human cytochromes P450 1A1 and 1B1 by metabolism of isoflavones found in Trifolium pratense (red clover).","15479032","daidzein","Cytochrome P-450 CYP1A1"]
["daidzin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","10597900",1999,"Inhibition of CYP1A1 enzyme activity in mouse hepatoma cell culture by soybean isoflavones.","10597900","daidzin","Cytochrome P-450 CYP1A1"]
["danthron","Retinoid X Receptor alpha_antag","Retinoid X Receptor alpha","antag","21084305",2011,"Danthron functions as a retinoic X receptor antagonist by stabilizing tetramers of the receptor.","21084305","danthron","Retinoid X Receptor alpha"]
["DDT","CYP1A1 protein, human_antag","CYP1A1 protein, human","antag","22358094",2011,"Effects of two isomers of DDT and their metabolite DDE on CYP1A1 and AhR function in human placental cells.","22358094","DDT","CYP1A1 protein, human"]
["DDT","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","22358094",2011,"Effects of two isomers of DDT and their metabolite DDE on CYP1A1 and AhR function in human placental cells.","22358094","DDT","Cytochrome P-450 CYP1A1"]
["decaborane","Retinoid X Receptors_antag","Retinoid X Receptors","antag","15501068",2004,"Novel retinoid X receptor (RXR) antagonists having a dicarba-closo-dodecaborane as a hydrophobic moiety.","15501068","decaborane","Retinoid X Receptors"]
["decalpenic acid","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","22618236",2012,"Decalpenic acid induces early osteoblastic markers in pluripotent mesenchymal cells via activation of retinoic acid receptor γ.","22618236","decalpenic acid","Receptors, Retinoic Acid"]
["decalpenic acid","retinoic acid receptor gamma_ag","retinoic acid receptor gamma","ag","22618236",2012,"Decalpenic acid induces early osteoblastic markers in pluripotent mesenchymal cells via activation of retinoic acid receptor γ.","22618236","decalpenic acid","retinoic acid receptor gamma"]
["Dehydroepiandrosterone","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","10575002",1999,"The steroid hormone dehydroepiandrosterone inhibits CYP1A1 expression in vitro by a post-transcriptional mechanism.","10575002","Dehydroepiandrosterone","Cytochrome P-450 CYP1A1"]
["Dehydroepiandrosterone","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","12097275",2002,"Inhibition of carcinogen-activating enzymes by 16alpha-fluoro-5-androsten-17-one.","12097275","Dehydroepiandrosterone","Cytochrome P-450 CYP1A1"]
["dehydroevodiamine","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","11854157",2002,"The alkaloid rutaecarpine is a selective inhibitor of cytochrome P450 1A in mouse and human liver microsomes.","11854157","dehydroevodiamine","Cytochrome P-450 CYP1A1"]
["dehydrosilybin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","16528449",2006,"Silybin and dehydrosilybin inhibit cytochrome P450 1A1 catalytic activity: a study in human keratinocytes and human hepatoma cells.","16528449","dehydrosilybin","Cytochrome P-450 CYP1A1"]
["Deoxycytidine","Retinoid X Receptors_ag","Retinoid X Receptors","ag","17483357",2007,"Bexarotene (LGD1069, Targretin), a selective retinoid X receptor agonist, prevents and reverses gemcitabine resistance in NSCLC cells by modulating gene amplification.","17483357","Deoxycytidine","Retinoid X Receptors"]
["desethylamiodarone","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","20201781",2010,"Assessment of the inactivation potential of desethylamiodarone on human CYP1A1.","20201781","desethylamiodarone","Cytochrome P-450 CYP1A1"]
["Dexamethasone","CYP1A1 protein, human_antag","CYP1A1 protein, human","antag","24091107",2013,"Dexamethasone accelerates degradation of aryl hydrocarbon receptor (AHR) and suppresses CYP1A1 induction in placental JEG-3 cell line.","24091107","Dexamethasone","CYP1A1 protein, human"]
["Dexamethasone","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","23466084",2013,"Clotrimazole, but not dexamethasone, is a potent in vitro inhibitor of cytochrome P450 isoforms CYP1A and CYP3A in rainbow trout.","23466084","Dexamethasone","Cytochrome P-450 CYP1A1"]
["Dexamethasone","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","24091107",2013,"Dexamethasone accelerates degradation of aryl hydrocarbon receptor (AHR) and suppresses CYP1A1 induction in placental JEG-3 cell line.","24091107","Dexamethasone","Cytochrome P-450 CYP1A1"]
["Dexamethasone","Retinoblastoma-Like Protein p130_antag","Retinoblastoma-Like Protein p130","antag","11441106",2001,"Glucocorticoid augmentation of macrophage capacity for phagocytosis of apoptotic cells is associated with reduced p130Cas expression, loss of paxillin/pyk2 phosphorylation, and high levels of active Rac.","11441106","Dexamethasone","Retinoblastoma-Like Protein p130"]
["diazepinylbenzoic acid","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","11712415",2001,"[The molecular mechanisms by which PPAR gamma/RXR inhibitors improve insulin resistance].","11712415","diazepinylbenzoic acid","Receptors, Retinoic Acid"]
["diazepinylbenzoic acid","Retinoid X Receptors_ag","Retinoid X Receptors","ag","15857749",2005,"HX531, a retinoid X receptor antagonist, inhibited the 9-cis retinoic acid-induced binding with steroid receptor coactivator-1 as detected by surface plasmon resonance.","15857749","diazepinylbenzoic acid","Retinoid X Receptors"]
["diazepinylbenzoic acid","Retinoid X Receptors_antag","Retinoid X Receptors","antag","11712415",2001,"[The molecular mechanisms by which PPAR gamma/RXR inhibitors improve insulin resistance].","11712415","diazepinylbenzoic acid","Retinoid X Receptors"]
["diazepinylbenzoic acid","Retinoid X Receptors_antag","Retinoid X Receptors","antag","15857749",2005,"HX531, a retinoid X receptor antagonist, inhibited the 9-cis retinoic acid-induced binding with steroid receptor coactivator-1 as detected by surface plasmon resonance.","15857749","diazepinylbenzoic acid","Retinoid X Receptors"]
["diazepinylbenzoic acid","Retinoid X Receptors_antag","Retinoid X Receptors","antag","15877285",2005,"A retinoid X receptor antagonist, HX531, improves leptin resistance without increasing plasma leptin level in KK-Ay mice under normal dietary conditions.","15877285","diazepinylbenzoic acid","Retinoid X Receptors"]
["diazepinylbenzoic acid","Retinoid X Receptors_antag","Retinoid X Receptors","antag","21956786",2012,"RXR antagonism induces G0 /G1 cell cycle arrest and ameliorates obesity by up-regulating the p53-p21(Cip1) pathway in adipocytes.","21956786","diazepinylbenzoic acid","Retinoid X Receptors"]
["diazepinylbenzoic acid","Retinoid X Receptors_antag","Retinoid X Receptors","antag","25261877",2014,"An antagonist of the retinoid X receptor reduces the viability of Trichuris muris in vitro.","25261877","diazepinylbenzoic acid","Retinoid X Receptors"]
["dibenzo(a,l)pyrene","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","25794985",2015,"Effect of phytochemical intervention on dibenzo[a,l]pyrene-induced DNA adduct formation.","25794985","dibenzo(a,l)pyrene","Cytochrome P-450 CYP1A1"]
["dibutylnitrosamine","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","17582584",2008,"Protective effects of isothiocyanates alone or in combination with vitamin C towards N-nitrosodibutylamine or N-nitrosopiperidine-induced oxidative DNA damage in the single-cell gel electrophoresis (SCGE)/HepG2 assay.","17582584","dibutylnitrosamine","Cytochrome P-450 CYP1A1"]
["Dicarbethoxydihydrocollidine","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","7763287",1995,"Inactivation of chick embryo hepatic cytochrome P450 1A, 2H and 3A following in ovo administration of 3,5-diethoxycarbonyl-1,4-dihydro-2,6-dimethyl-4-ethylpyridine and 3-[2-(2,4,6-trimethylphenyl)thioethyl]-4-methylsydnone.","7763287","Dicarbethoxydihydrocollidine","Cytochrome P-450 CYP1A1"]
["Dichlorodiphenyl Dichloroethylene","CYP1A1 protein, human_antag","CYP1A1 protein, human","antag","22358094",2011,"Effects of two isomers of DDT and their metabolite DDE on CYP1A1 and AhR function in human placental cells.","22358094","Dichlorodiphenyl Dichloroethylene","CYP1A1 protein, human"]
["Dichlorodiphenyl Dichloroethylene","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","22358094",2011,"Effects of two isomers of DDT and their metabolite DDE on CYP1A1 and AhR function in human placental cells.","22358094","Dichlorodiphenyl Dichloroethylene","Cytochrome P-450 CYP1A1"]
["Diclofenac","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","19276279",2009,"Novel dithiolethione-modified nonsteroidal anti-inflammatory drugs in human hepatoma HepG2 and colon LS180 cells.","19276279","Diclofenac","Cytochrome P-450 CYP1A1"]
["difloxacin",{"$f":"C771&\"_\"&D771","v":"Cytochrome P-450 CYP1A1_antag"},"Cytochrome P-450 CYP1A1","antag","21787699",2011,"Effects of cytochrome P450 1A substrate (difloxacin) on enzyme gene expression and pharmacokinetics in crucian carp (hybridized Prussian carp).","21787699","difloxacin","Cytochrome P-450 CYP1A1"]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  I772,I772)","v":"Diflubenzuron"},"Cytochrome P-450 CYP1A1_antag",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  J772,J772)","v":"Cytochrome P-450 CYP1A1"},"antag",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & H772,H772)","v":"10799337"},2000,"Diflubenzuron, a benzoyl-urea insecticide, is a potent inhibitor of TCDD-induced CYP1A1 expression in HepG2 cells.","10799337","Diflubenzuron","Cytochrome P-450 CYP1A1"]
["dihydroanthracenyl retinoid","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","10201840",1999,"A new class of potent RAR antagonists: dihydroanthracenyl, benzochromenyl and benzothiochromenyl retinoids.","10201840","dihydroanthracenyl retinoid","Receptors, Retinoic Acid"]
["dihydronarciclasine","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","21105682",2011,"Human cytochrome P450 liability studies of trans-dihydronarciclasine: a readily available, potent, and selective cancer cell growth inhibitor.","21105682","dihydronarciclasine","Cytochrome P-450 CYP1A1"]
["dihydrosafrole","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","3660849",1987,"Inhibition of cytochrome P-450c-mediated benzo[a]pyrene hydroxylase and ethoxyresorufin O-deethylase by dihydrosafrole.","3660849","dihydrosafrole","Cytochrome P-450 CYP1A1"]
["diindolylmethane","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","18486294",2008,"Inhibitory effects of a dietary phytochemical 3,3'-diindolylmethane on the phenobarbital-induced hepatic CYP mRNA expression and CYP-catalyzed reactions in female rats.","18486294","diindolylmethane","Cytochrome P-450 CYP1A1"]
["dimethylcyanamide","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","7115421",1982,"Studies on the cyanamide-ethanol interaction. Dimethylcyanamide as an inhibitor of aldehyde dehydrogenase in vivo.","7115421","dimethylcyanamide","Aldehyde Oxidoreductases"]
["Dimethylformamide","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","255840",1979,"Case history: alcohol interaction with a workplace chemical.","255840","Dimethylformamide","Aldehyde Oxidoreductases"]
["Dinoprostone","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","19264469",2009,"Effects of leukotriene B4 and prostaglandin E2 on the differentiation of murine Foxp3+ T regulatory cells and Th17 cells.","19264469","Dinoprostone","Receptors, Retinoic Acid"]
["Dinoprostone","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","19264469",2009,"Effects of leukotriene B4 and prostaglandin E2 on the differentiation of murine Foxp3+ T regulatory cells and Th17 cells.","19264469","Dinoprostone","Receptors, Retinoic Acid"]
["Diphenylamine","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","21459577",2011,"Diphenylamine-based retinoid antagonists: regulation of RAR and RXR function depending on the N-substituent.","21459577","Diphenylamine","Receptors, Retinoic Acid"]
["Diphenylamine","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","21459577",2011,"Diphenylamine-based retinoid antagonists: regulation of RAR and RXR function depending on the N-substituent.","21459577","Diphenylamine","Receptors, Retinoic Acid"]
["Diphenylamine","Retinoid X Receptors_ag","Retinoid X Receptors","ag","21459577",2011,"Diphenylamine-based retinoid antagonists: regulation of RAR and RXR function depending on the N-substituent.","21459577","Diphenylamine","Retinoid X Receptors"]
["Diphenylamine","Retinoid X Receptors_antag","Retinoid X Receptors","antag","21459577",2011,"Diphenylamine-based retinoid antagonists: regulation of RAR and RXR function depending on the N-substituent.","21459577","Diphenylamine","Retinoid X Receptors"]
["disila-tamibarotene","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","19790202",2009,"Synthesis and pharmacological characterization of Disila-AM80 (Disila-tamibarotene) and Disila-AM580, silicon analogues of the RARalpha-selective retinoid agonists AM80 (Tamibarotene) and AM580.","19790202","disila-tamibarotene","Receptors, Retinoic Acid"]
["disila-tamibarotene","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","19790202",2009,"Synthesis and pharmacological characterization of Disila-AM80 (Disila-tamibarotene) and Disila-AM580, silicon analogues of the RARalpha-selective retinoid agonists AM80 (Tamibarotene) and AM580.","19790202","disila-tamibarotene","retinoic acid receptor alpha"]
["Disulfiram","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","1241098",1975,"Isolation and structural studies of coprine, the disulfiram-like constituent of Coprinus atramentarius.","1241098","Disulfiram","Aldehyde Oxidoreductases"]
["Disulfiram","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","12604199",2003,"Inactivation of betaine aldehyde dehydrogenase from Pseudomonas aeruginosa and Amaranthus hypochondriacus L. leaves by disulfiram.","12604199","Disulfiram","Aldehyde Oxidoreductases"]
["Disulfiram","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","20082270",2010,"DNA repair mutant pso2 of Saccharomyces cerevisiae is sensitive to intracellular acetaldehyde accumulated by disulfiram-mediated inhibition of acetaldehyde dehydrogenase.","20082270","Disulfiram","Aldehyde Oxidoreductases"]
["Disulfiram","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","2438009",1987,"Effects of aldehyde dehydrogenase inhibitors on hexobarbital sensitivity and neuroamine metabolism in rat brain.","2438009","Disulfiram","Aldehyde Oxidoreductases"]
["Disulfiram","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","2690658",1989,"Human brain glyceraldehyde-3-phosphate dehydrogenase, succinic semialdehyde dehydrogenase and aldehyde dehydrogenase isozymes: substrate specificity and sensitivity to disulfiram.","2690658","Disulfiram","Aldehyde Oxidoreductases"]
["Disulfiram","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","3167",1975,"The effect of disulfiram on the aldehyde dehydrogenases of sheep liver.","3167","Disulfiram","Aldehyde Oxidoreductases"]
["Disulfiram","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","4357069",1973,"Effect of disulfiram on the urinary D-glucaric acid excretion and activity of some enzymes involved in drug metabolism in guinea-pig.","4357069","Disulfiram","Aldehyde Oxidoreductases"]
["Disulfiram","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","449612",1979,"Susceptibility of brain aldehyde metabolizing enzymes to pargyline, disulfiram and diethylmaleate in vivo in rats.","449612","Disulfiram","Aldehyde Oxidoreductases"]
["Disulfiram","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","475776",1979,"The separation of sheep liver cytoplasmic and mitochondrial aldehyde dehydrogenases by isoelectric focusing, and observations on the purity of preparations of the cytoplasmic enzyme, and their sensitivity towards inhibition by disulfiram.","475776","Disulfiram","Aldehyde Oxidoreductases"]
["Disulfiram","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","515041",1979,"Disulfiram inhibition and pentobarbital induction of rat testicular aldehyde dehydrogenase.","515041","Disulfiram","Aldehyde Oxidoreductases"]
["Disulfiram","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","540042",1979,"2,2'-Dithiodipyridine activates aldehyde dehydrogenase and protects the enzyme against inactivation by disulfiram.","540042","Disulfiram","Aldehyde Oxidoreductases"]
["Disulfiram","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","6114276",1981,"\"Burning off the antabuse\": fact or fiction?","6114276","Disulfiram","Aldehyde Oxidoreductases"]
["Disulfiram","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","6278237",1982,"Effect of disulfiram and its reduced metabolite, diethyl-dithiocarbamate on aldehyde dehydrogenase of human erythrocytes.","6278237","Disulfiram","Aldehyde Oxidoreductases"]
["Disulfiram","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","6318974",1984,"Inhibition of etoposide-induced DNA damage and cytotoxicity in L1210 cells by dehydrogenase inhibitors and other agents.","6318974","Disulfiram","Aldehyde Oxidoreductases"]
["Disulfiram","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","633898",1978,"On the probability of implanted disulfiram's causing a reaction to ethanol.","633898","Disulfiram","Aldehyde Oxidoreductases"]
["Disulfiram","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","6346928",1983,"Effects of oral administration or implantation of disulfiram on aldehyde dehydrogenase activity in human blood.","6346928","Disulfiram","Aldehyde Oxidoreductases"]
["Disulfiram","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","6364020",1983,"[Ketosis and acetonemia in alcoholic intoxication and the effect of teturam. Possible causes and mechanisms of development].","6364020","Disulfiram","Aldehyde Oxidoreductases"]
["Disulfiram","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","6615449",1983,"Mechanism of inactivation of sheep liver cytoplasmic aldehyde dehydrogenase by disulfiram.","6615449","Disulfiram","Aldehyde Oxidoreductases"]
["Disulfiram","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","6634824",1983,"Aldehyde dehydrogenase in blood: a sensitive assay and inhibition by disulfiram.","6634824","Disulfiram","Aldehyde Oxidoreductases"]
["Disulfiram","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","6634868",1983,"Interaction of human cytoplasmic aldehyde dehydrogenase E1 with disulfiram.","6634868","Disulfiram","Aldehyde Oxidoreductases"]
["Disulfiram","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","6831831",1983,"Disulfiram and erythrocyte aldehyde dehydrogenase inhibition.","6831831","Disulfiram","Aldehyde Oxidoreductases"]
["Disulfiram","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","6870943",1983,"Studies in vitro on the inactivation of mitochondrial rat-liver aldehyde dehydrogenase by the alcohol-sensitizing compounds cyanamide, 1-aminocyclopropanol and disulfiram.","6870943","Disulfiram","Aldehyde Oxidoreductases"]
["Disulfiram","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","7028794",1981,"A comparative review of the pharmacological and toxicological properties of disulfiram and calcium carbimide.","7028794","Disulfiram","Aldehyde Oxidoreductases"]
["Disulfiram","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","7038717",1981,"The disulfiram and calcium carbimide acetaldehyde-mediated ethanol reactions.","7038717","Disulfiram","Aldehyde Oxidoreductases"]
["Disulfiram","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","7053207",1980,"Differentiation of normal and inducible rat liver aldehyde dehydrogenases by disulfiram inhibition in vitro.","7053207","Disulfiram","Aldehyde Oxidoreductases"]
["Disulfiram","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","7071604",1982,"Human aldehyde dehydrogenase: mechanism of inhibition of disulfiram.","7071604","Disulfiram","Aldehyde Oxidoreductases"]
["Disulfiram","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","7097272",1982,"Inhibition of aldehyde dehydrogenases in rat brain and liver by disulfiram and coprine.","7097272","Disulfiram","Aldehyde Oxidoreductases"]
["Disulfiram","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","7115312",1982,"Further studies of the action of disulfiram and 2,2'-dithiodipyridine on the dehydrogenase and esterase activities of sheep liver cytoplasmic aldehyde dehydrogenase.","7115312","Disulfiram","Aldehyde Oxidoreductases"]
["Disulfiram","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","7135154",1982,"Mechanism of alcohol sensitivity and disulfiram-ethanol reaction.","7135154","Disulfiram","Aldehyde Oxidoreductases"]
["Disulfiram","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","7337707",1981,"The inactivation of aldehyde dehydrogenase by disulfiram in the presence of glutathione.","7337707","Disulfiram","Aldehyde Oxidoreductases"]
["Disulfiram","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","736907",1978,"Studies on the interaction between disulfiram and sheep liver cytoplasmic aldehyde dehydrogenase.","736907","Disulfiram","Aldehyde Oxidoreductases"]
["Disulfiram","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","7424721",1980,"On the interaction of human liver aldehyde dehydrogenase E1 isoenzyme with disulfiram and iodoacetamide.","7424721","Disulfiram","Aldehyde Oxidoreductases"]
["Disulfiram","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","938491",1976,"The effect of some analogues of disulfiram on the aldehyde dehydrogenases of sheep liver.","938491","Disulfiram","Aldehyde Oxidoreductases"]
["Dithizone","promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein_antag","promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein","antag","12008084",2002,"A metal chelator, diphenylthiocarbazone, induces apoptosis in acute promyelocytic leukemia (APL) cells mediated by a caspase-dependent pathway without a modulation of retinoic acid signaling pathways.","12008084","Dithizone","promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein"]
["Ditiocarb","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","6263219",1980,"Effects of pargyline and diethyldithiocarbamate in vivo treatment on aldehyde dehydrogenase activities of submitochondrial fractions.","6263219","Ditiocarb","Aldehyde Oxidoreductases"]
["Ditiocarb","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","6278237",1982,"Effect of disulfiram and its reduced metabolite, diethyl-dithiocarbamate on aldehyde dehydrogenase of human erythrocytes.","6278237","Ditiocarb","Aldehyde Oxidoreductases"]
["Ditiocarb","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","6318974",1984,"Inhibition of etoposide-induced DNA damage and cytotoxicity in L1210 cells by dehydrogenase inhibitors and other agents.","6318974","Ditiocarb","Aldehyde Oxidoreductases"]
["DNA-(2-amino-3-methylimidazo(4,5-f)quinoline) adduct","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","11752233",2002,"Flavonoids inhibit genetic toxicity produced by carcinogens in cells expressing CYP1A2 and CYP1A1.","11752233","DNA-(2-amino-3-methylimidazo(4,5-f)quinoline) adduct","Cytochrome P-450 CYP1A1"]
["Dopamine","Secretin_antag","Secretin","antag","6313394",1983,"Effects of dopamine on exocrine secretion and cyclic nucleotide concentration in the dog pancreas.","6313394","Dopamine","Secretin"]
["Dopamine","Secretin_antag","Secretin","antag","6443810",1984,"[Effect of dopamine and haloperidol on the exocrine function of the rat pancreas in vivo].","6443810","Dopamine","Secretin"]
["Dydrogesterone","Retinoid X Receptor alpha_antag","Retinoid X Receptor alpha","antag","24936658",2014,"The human orphan nuclear receptor tailless (TLX, NR2E1) is druggable.","24936658","Dydrogesterone","Retinoid X Receptor alpha"]
["elaidic acid","Retinoid X Receptors_ag","Retinoid X Receptors","ag","23800855",2013,"Differential regulation of ABCA1 and macrophage cholesterol efflux by elaidic and oleic acids.","23800855","elaidic acid","Retinoid X Receptors"]
["Ellagic Acid","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","12604171",2003,"Effect of naturally occurring plant phenolics on the induction of drug metabolizing enzymes by o-toluidine.","12604171","Ellagic Acid","Cytochrome P-450 CYP1A1"]
["emixustat","retinoid isomerohydrolase_antag","retinoid isomerohydrolase","antag","25932553",2015,"Phase ii, randomized, placebo-controlled, 90-day study of emixustat hydrochloride in geographic atrophy associated with dry age-related macular degeneration.","25932553","emixustat","retinoid isomerohydrolase"]
["emixustat","retinoid isomerohydrolase_antag","retinoid isomerohydrolase","antag","26075817",2015,"Molecular pharmacodynamics of emixustat in protection against retinal degeneration.","26075817","emixustat","retinoid isomerohydrolase"]
["Endosulfan","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","11358810",2001,"Differential regulation of cytochrome P450 1A1 and 1B1 by a combination of dioxin and pesticides in the breast tumor cell line MCF-7.","11358810","Endosulfan","Cytochrome P-450 CYP1A1"]
["eniluracil","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","8161345",1994,"5-ethynyl-2(1H)-pyrimidinone: aldehyde oxidase-activation to 5-ethynyluracil, a mechanism-based inactivator of dihydropyrimidine dehydrogenase.","8161345","eniluracil","Aldehyde Oxidoreductases"]
["enrofloxacin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","16343288",2005,"Inhibitory effect of several fluoroquinolones on hepatic microsomal cytochrome P-450 1A activities in dogs.","16343288","enrofloxacin","Cytochrome P-450 CYP1A1"]
["epigallocatechin gallate",{"$f":"C835&\"_\"&D835","v":"Cytochrome P-450 CYP1A1_antag"},"Cytochrome P-450 CYP1A1","antag","12670496",2003,"In vitro assessment of inhibition by natural polyphenols of metabolic activation of procarcinogens by human CYP1A1.","12670496","epigallocatechin gallate","Cytochrome P-450 CYP1A1"]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  I836,I836)","v":"Epoprostenol"},"Receptors, Retinoic Acid_ag",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  J836,J836)","v":"Receptors, Retinoic Acid"},"ag",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & H836,H836)","v":"11708867"},2001,"Limited cooperation between peroxisome proliferator-activated receptors and retinoid X receptor agonists in sebocyte growth and development.","11708867","Epoprostenol","Receptors, Retinoic Acid"]
["Epoprostenol","Retinoid X Receptors_ag","Retinoid X Receptors","ag","11708867",2001,"Limited cooperation between peroxisome proliferator-activated receptors and retinoid X receptor agonists in sebocyte growth and development.","11708867","Epoprostenol","Retinoid X Receptors"]
["Epoprostenol","Secretin_antag","Secretin","antag","6990728",1980,"Effect of prostacyclin on pancreatic secretion in dogs.","6990728","Epoprostenol","Secretin"]
["ER 34617","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","10669568",2000,"Syntheses and structure-activity relationships of 5,6,7, 8-tetrahydro-5,5,8,8-tetramethyl-2-quinoxaline derivatives with retinoic acid receptor alpha agonistic activity.","10669568","ER 34617","Receptors, Retinoic Acid"]
["ER 34617","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","10715409",2000,"Prolongation of mouse skin allograft survival by novel agonists selective for retinoic acid receptor-alpha.","10715409","ER 34617","Receptors, Retinoic Acid"]
["ER 34617","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","10669568",2000,"Syntheses and structure-activity relationships of 5,6,7, 8-tetrahydro-5,5,8,8-tetramethyl-2-quinoxaline derivatives with retinoic acid receptor alpha agonistic activity.","10669568","ER 34617","retinoic acid receptor alpha"]
["ER 34617","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","10715409",2000,"Prolongation of mouse skin allograft survival by novel agonists selective for retinoic acid receptor-alpha.","10715409","ER 34617","retinoic acid receptor alpha"]
["ER 38925","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","10715409",2000,"Prolongation of mouse skin allograft survival by novel agonists selective for retinoic acid receptor-alpha.","10715409","ER 38925","Receptors, Retinoic Acid"]
["ER 38925","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","10956201",2000,"Discovery of novel and potent retinoic acid receptor alpha agonists: syntheses and evaluation of benzofuranyl-pyrrole and benzothiophenyl-pyrrole derivatives.","10956201","ER 38925","Receptors, Retinoic Acid"]
["ER 38925","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","15096490",2004,"Prevention of acute and chronic allograft rejection by a novel retinoic acid receptor-alpha-selective agonist.","15096490","ER 38925","Receptors, Retinoic Acid"]
["ER 38925","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","10715409",2000,"Prolongation of mouse skin allograft survival by novel agonists selective for retinoic acid receptor-alpha.","10715409","ER 38925","retinoic acid receptor alpha"]
["ER 38925","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","10956201",2000,"Discovery of novel and potent retinoic acid receptor alpha agonists: syntheses and evaluation of benzofuranyl-pyrrole and benzothiophenyl-pyrrole derivatives.","10956201","ER 38925","retinoic acid receptor alpha"]
["ER 38925","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","15096490",2004,"Prevention of acute and chronic allograft rejection by a novel retinoic acid receptor-alpha-selective agonist.","15096490","ER 38925","retinoic acid receptor alpha"]
["erucin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","18479797",2008,"Antigenotoxic properties of Eruca sativa (rocket plant), erucin and erysolin in human hepatoma (HepG2) cells towards benzo(a)pyrene and their mode of action.","18479797","erucin","Cytochrome P-450 CYP1A1"]
["erysolin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","18479797",2008,"Antigenotoxic properties of Eruca sativa (rocket plant), erucin and erysolin in human hepatoma (HepG2) cells towards benzo(a)pyrene and their mode of action.","18479797","erysolin","Cytochrome P-450 CYP1A1"]
["Erythromycin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","2395109",1990,"Inhibition of rat liver estrogen 2/4-hydroxylase activity by troleandomycin: comparison with erythromycin and roxithromycin.","2395109","Erythromycin","Cytochrome P-450 CYP1A1"]
["Erythromycin","retinyl esterase_antag","retinyl esterase","antag","12214558",2002,"Vitamin A metabolism is altered in brown Norway and long-Evans rats infused with naftidrofuryl or erythromycin intravenously.","12214558","Erythromycin","retinyl esterase"]
["Estradiol","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","12093619",2002,"Estradiol enhances and estriol inhibits the expression of CYP1A1 induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in a mouse ovarian cancer cell line.","12093619","Estradiol","Cytochrome P-450 CYP1A1"]
["Estradiol","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","12810639",2003,"Methoxyestrogens exert feedback inhibition on cytochrome P450 1A1 and 1B1.","12810639","Estradiol","Cytochrome P-450 CYP1A1"]
["Estradiol","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","1386303",1992,"Elevated 4-hydroxylation of estradiol by hamster kidney microsomes: a potential pathway of metabolic activation of estrogens.","1386303","Estradiol","Cytochrome P-450 CYP1A1"]
["Estradiol","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","16219370",2005,"Effects of 17beta-estradiol, 4-nonylphenol and PCB 126 on the estrogenic activity and phase 1 and 2 biotransformation enzymes in male sea bass (Dicentrarchus labrax).","16219370","Estradiol","Cytochrome P-450 CYP1A1"]
["Estradiol","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","8095225",1993,"Caffeine, estradiol, and progesterone interact with human CYP1A1 and CYP1A2. Evidence from cDNA-directed expression in Saccharomyces cerevisiae.","8095225","Estradiol","Cytochrome P-450 CYP1A1"]
["Estradiol","Retinoblastoma Protein_antag","Retinoblastoma Protein","antag","11032025",2000,"Reversal of an antiestrogen-mediated cell cycle arrest of MCF-7 cells by viral tumor antigens requires the retinoblastoma protein-binding domain.","11032025","Estradiol","Retinoblastoma Protein"]
["Estriol","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","12093619",2002,"Estradiol enhances and estriol inhibits the expression of CYP1A1 induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in a mouse ovarian cancer cell line.","12093619","Estriol","Cytochrome P-450 CYP1A1"]
["Ethanol","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","12198016",2002,"Generation of protein adducts with malondialdehyde and acetaldehyde in muscles with predominantly type I or type II fibers in rats exposed to ethanol and the acetaldehyde dehydrogenase inhibitor cyanamide.","12198016","Ethanol","Aldehyde Oxidoreductases"]
["Ethanol","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","18003597",2008,"PPARalpha and PPARbeta are differentially affected by ethanol and the ethanol metabolite acetaldehyde in the MCF-7 breast cancer cell line.","18003597","Ethanol","Aldehyde Oxidoreductases"]
["Ethanol","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","2363695",1990,"The role of aldehyde oxidase in ethanol-induced hepatic lipid peroxidation in the rat.","2363695","Ethanol","Aldehyde Oxidoreductases"]
["Ethanol","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","255840",1979,"Case history: alcohol interaction with a workplace chemical.","255840","Ethanol","Aldehyde Oxidoreductases"]
["Ethanol","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","3374631",1988,"A comment on Dr. Mack's article.","3374631","Ethanol","Aldehyde Oxidoreductases"]
["Ethanol","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","3911383",1985,"[Alcohol, alcoholism and drugs].","3911383","Ethanol","Aldehyde Oxidoreductases"]
["Ethanol","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","4426143",1974,"The biochemical pharmacology of abused drugs. II. Alcohol and barbiturates.","4426143","Ethanol","Aldehyde Oxidoreductases"]
["Ethanol","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","4513686",1973,"Alcohol, aldehydes, and biogenic amines.","4513686","Ethanol","Aldehyde Oxidoreductases"]
["Ethanol","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","4644236",1972,"The hypocalcemic effect of ethyl alcohol in rats and dogs.","4644236","Ethanol","Aldehyde Oxidoreductases"]
["Ethanol","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","4662153",1972,"The effect of ethanol concentration upon in vivo metabolite levels of rat liver.","4662153","Ethanol","Aldehyde Oxidoreductases"]
["Ethanol","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","4790789",1973,"Ethanol-induced inhibition in liver and blood serum xanthine dehydrogenase.","4790789","Ethanol","Aldehyde Oxidoreductases"]
["Ethanol","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","6114276",1981,"\"Burning off the antabuse\": fact or fiction?","6114276","Ethanol","Aldehyde Oxidoreductases"]
["Ethanol","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","6733600",1984,"Decrease in calcium carbimide (calcium cyanamide)-induced inhibition of rat hepatic aldehyde dehydrogenases by multiple ethanol administration.","6733600","Ethanol","Aldehyde Oxidoreductases"]
["Ethanol","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","7038717",1981,"The disulfiram and calcium carbimide acetaldehyde-mediated ethanol reactions.","7038717","Ethanol","Aldehyde Oxidoreductases"]
["Ethanol","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","7135154",1982,"Mechanism of alcohol sensitivity and disulfiram-ethanol reaction.","7135154","Ethanol","Aldehyde Oxidoreductases"]
["Ethanol","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","920492",1977,"The effects of ethanol on dopamine metabolism in rat liver and brain.","920492","Ethanol","Aldehyde Oxidoreductases"]
["Ethanol","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","20201933",2010,"Ethanol impairs activation of retinoic acid receptors in cerebellar granule cells in a rodent model of fetal alcohol spectrum disorders.","20201933","Ethanol","Receptors, Retinoic Acid"]
["Ethanol","Retinoblastoma Protein_antag","Retinoblastoma Protein","antag","18341643",2008,"Ethanol induces apoptotic death of beta-endorphin neurons in the rat hypothalamus by a TGF-beta 1-dependent mechanism.","18341643","Ethanol","Retinoblastoma Protein"]
["Ethanol","retinoic acid receptor alpha_antag","retinoic acid receptor alpha","antag","20201933",2010,"Ethanol impairs activation of retinoic acid receptors in cerebellar granule cells in a rodent model of fetal alcohol spectrum disorders.","20201933","Ethanol","retinoic acid receptor alpha"]
["Ethanol","retinoic acid receptor gamma_antag","retinoic acid receptor gamma","antag","20201933",2010,"Ethanol impairs activation of retinoic acid receptors in cerebellar granule cells in a rodent model of fetal alcohol spectrum disorders.","20201933","Ethanol","retinoic acid receptor gamma"]
["Ethinyl Estradiol","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","19454483",2009,"Further assessment of 17alpha-ethinyl estradiol as an inhibitor of different human cytochrome P450 forms in vitro.","19454483","Ethinyl Estradiol","Cytochrome P-450 CYP1A1"]
["ethylbenzene","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","20096743",2010,"In vitro metabolism and covalent binding of ethylbenzene to microsomal protein as a possible mechanism of ethylbenzene-induced mouse lung tumorigenesis.","20096743","ethylbenzene","Cytochrome P-450 CYP1A1"]
["ethylisopropylamiloride","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","15081870",2004,"Inhibition of carcinogen-bioactivating cytochrome P450 1 isoforms by amiloride derivatives.","15081870","ethylisopropylamiloride","Cytochrome P-450 CYP1A1"]
["Etodolac","Retinoid X Receptor alpha_antag","Retinoid X Receptor alpha","antag","26275572",2015,"A window-of-opportunity biomarker study of etodolac in resectable breast cancer.","26275572","Etodolac","Retinoid X Receptor alpha"]
["Etoposide","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","6318974",1984,"Inhibition of etoposide-induced DNA damage and cytotoxicity in L1210 cells by dehydrogenase inhibitors and other agents.","6318974","Etoposide","Aldehyde Oxidoreductases"]
["eucalyptol","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","10454222",1999,"In vitro inhibition of liver monooxygenases by beta-ionone, 1,8-cineole, (-)-menthol and terpineol.","10454222","eucalyptol","Cytochrome P-450 CYP1A1"]
["evodiamine","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","11854157",2002,"The alkaloid rutaecarpine is a selective inhibitor of cytochrome P450 1A in mouse and human liver microsomes.","11854157","evodiamine","Cytochrome P-450 CYP1A1"]
["Famotidine","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","2878667",1986,"Effect of five structurally diverse H2-receptor antagonists on drug metabolism.","2878667","Famotidine","Cytochrome P-450 CYP1A1"]
["Farnesol","retinoid isomerohydrolase_antag","retinoid isomerohydrolase","antag","18195010",2008,"Metabolic basis of visual cycle inhibition by retinoid and nonretinoid compounds in the vertebrate retina.","18195010","Farnesol","retinoid isomerohydrolase"]
["farnesylamine","retinoid isomerohydrolase_antag","retinoid isomerohydrolase","antag","18195010",2008,"Metabolic basis of visual cycle inhibition by retinoid and nonretinoid compounds in the vertebrate retina.","18195010","farnesylamine","retinoid isomerohydrolase"]
["Fenofibrate","Retinoid X Receptors_ag","Retinoid X Receptors","ag","16525649",2006,"Effects of PPAR and RXR ligands in semaphorin 6B gene expression of human MCF-7 breast cancer cells.","16525649","Fenofibrate","Retinoid X Receptors"]
["Fenretinide","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","10051523",1999,"Induction of apoptosis by N-(4-hydroxyphenyl)retinamide and its association with reactive oxygen species, nuclear retinoic acid receptors, and apoptosis-related genes in human prostate carcinoma cells.","10051523","Fenretinide","Receptors, Retinoic Acid"]
["Fenretinide","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","11010810",2000,"Effector mechanisms of fenretinide-induced apoptosis in neuroblastoma.","11010810","Fenretinide","Receptors, Retinoic Acid"]
["Fenretinide","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","12234979",2002,"GADD153 and 12-lipoxygenase mediate fenretinide-induced apoptosis of neuroblastoma.","12234979","Fenretinide","Receptors, Retinoic Acid"]
["Fenretinide","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","12815470",2003,"Fenretinide induces cytochrome c release, caspase 9 activation and apoptosis in the absence of mitochondrial membrane depolarisation.","12815470","Fenretinide","Receptors, Retinoic Acid"]
["Fenretinide","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","12880976",2003,"Induction of GADD153 and Bak: novel molecular targets of fenretinide-induced apoptosis of neuroblastoma.","12880976","Fenretinide","Receptors, Retinoic Acid"]
["Fenretinide","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","16972258",2006,"N-(4-hydroxyphenyl)retinamide induces apoptosis in human retinal pigment epithelial cells: retinoic acid receptors regulate apoptosis, reactive oxygen species generation, and the expression of heme oxygenase-1 and Gadd153.","16972258","Fenretinide","Receptors, Retinoic Acid"]
["Fenretinide","retinoic acid receptor beta_antag","retinoic acid receptor beta","antag","12234979",2002,"GADD153 and 12-lipoxygenase mediate fenretinide-induced apoptosis of neuroblastoma.","12234979","Fenretinide","retinoic acid receptor beta"]
["Fenretinide","retinoic acid receptor gamma_antag","retinoic acid receptor gamma","antag","12234979",2002,"GADD153 and 12-lipoxygenase mediate fenretinide-induced apoptosis of neuroblastoma.","12234979","Fenretinide","retinoic acid receptor gamma"]
["Fenretinide",{"$f":"C899&\"_\"&D899","v":"Retinol-Binding Proteins, Plasma_antag"},"Retinol-Binding Proteins, Plasma","antag","23023528",2013,"Investigation of oral fenretinide for treatment of geographic atrophy in age-related macular degeneration.","23023528","Fenretinide","Retinol-Binding Proteins, Plasma"]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  I900,I900)","v":"ferrocene"},"Receptors, Retinoic Acid_ag",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  J900,J900)","v":"Receptors, Retinoic Acid"},"ag",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & H900,H900)","v":"21506276"},2011,"Design and stereoselective synthesis of retinoids with ferrocene or N-butylcarbazole pharmacophores that induce post-differentiation apoptosis in acute promyelocytic leukemia cells.","21506276","ferrocene","Receptors, Retinoic Acid"]
["ferrocene","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","21506276",2011,"Design and stereoselective synthesis of retinoids with ferrocene or N-butylcarbazole pharmacophores that induce post-differentiation apoptosis in acute promyelocytic leukemia cells.","21506276","ferrocene","retinoic acid receptor alpha"]
["Fingolimod Hydrochloride","Retinoblastoma Protein_antag","Retinoblastoma Protein","antag","12723592",2003,"Elimination of cell-cycle regulators during caspase-3-dependent apoptosis caused by an immunosuppressant, FTY720.","12723592","Fingolimod Hydrochloride","Retinoblastoma Protein"]
["flavanone","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","8201941",1994,"The structure-activity relationships of flavonoids as inhibitors of cytochrome P-450 enzymes in rat liver microsomes and the mutagenicity of 2-amino-3-methyl-imidazo[4,5-f]quinoline.","8201941","flavanone","Cytochrome P-450 CYP1A1"]
["Fluconazole","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","17283379",2007,"Induction of cytochrome P450 1A1 by ketoconazole and itraconazole but not fluconazole in murine and human hepatoma cell lines.","17283379","Fluconazole","Cytochrome P-450 CYP1A1"]
["fluoranthene","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","9586956",1998,"Inhibition of CYP1A1-dependent activity by the polynuclear aromatic hydrocarbon (PAH) fluoranthene.","9586956","fluoranthene","Cytochrome P-450 CYP1A1"]
["Fluoxetine","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","9690983",1998,"Effect of fluoxetine on the plasma concentrations of clozapine and its major metabolites in patients with schizophrenia.","9690983","Fluoxetine","Cytochrome P-450 CYP1A1"]
["Fluoxetine","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","25981674",2015,"Direct inhibition of retinoic acid catabolism by fluoxetine.","25981674","Fluoxetine","Receptors, Retinoic Acid"]
["Fluvoxamine","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","8737959",1996,"Influence of fluvoxamine on tacrine metabolism in vitro: potential implication for the hepatotoxicity in vivo.","8737959","Fluvoxamine","Cytochrome P-450 CYP1A1"]
["Fluvoxamine","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","9105404",1997,"Distinction of CYP1A1 and CYP1A2 activity by selective inhibition using fluvoxamine and isosafrole.","9105404","Fluvoxamine","Cytochrome P-450 CYP1A1"]
["Formaldehyde","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","1029022",1976,"Protection against toxic effects of formaldehyde in vitro, and of methanol or formaldehyde in vivo, by subsequent administration of SH reagents.","1029022","Formaldehyde","Aldehyde Oxidoreductases"]
["Formaldehyde","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","11306052",2001,"The formaldehyde metabolic detoxification enzyme systems and molecular cytotoxic mechanism in isolated rat hepatocytes.","11306052","Formaldehyde","Aldehyde Oxidoreductases"]
["formononetin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","15479032",2004,"Inhibition of extrahepatic human cytochromes P450 1A1 and 1B1 by metabolism of isoflavones found in Trifolium pratense (red clover).","15479032","formononetin","Cytochrome P-450 CYP1A1"]
["fulvestrant","Retinoblastoma Protein_antag","Retinoblastoma Protein","antag","11032025",2000,"Reversal of an antiestrogen-mediated cell cycle arrest of MCF-7 cells by viral tumor antigens requires the retinoblastoma protein-binding domain.","11032025","fulvestrant","Retinoblastoma Protein"]
["furafylline","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","11854157",2002,"The alkaloid rutaecarpine is a selective inhibitor of cytochrome P450 1A in mouse and human liver microsomes.","11854157","furafylline","Cytochrome P-450 CYP1A1"]
["furafylline","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","12495659",2003,"The presence of inducible cytochrome P450 types 1A1 and 1A2 in the BeWo cell line.","12495659","furafylline","Cytochrome P-450 CYP1A1"]
["furafylline","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","7975717",1994,"Characterization of the inhibition of P4501A2 by furafylline.","7975717","furafylline","Cytochrome P-450 CYP1A1"]
["galangin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","10188874",1999,"The flavonoid galangin is an inhibitor of CYP1A1 activity and an agonist/antagonist of the aryl hydrocarbon receptor.","10188874","galangin","Cytochrome P-450 CYP1A1"]
["galangin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","20550209",2010,"Metabolites of galangin by 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible cytochrome P450 1A1 in human intestinal epithelial Caco-2 cells and their antagonistic activity toward aryl hydrocarbon receptor.","20550209","galangin","Cytochrome P-450 CYP1A1"]
["gemcitabine","Retinoid X Receptors_ag","Retinoid X Receptors","ag","17483357",2007,"Bexarotene (LGD1069, Targretin), a selective retinoid X receptor agonist, prevents and reverses gemcitabine resistance in NSCLC cells by modulating gene amplification.","17483357","gemcitabine","Retinoid X Receptors"]
["genipin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","23940731",2013,"Requirement of retinoic acid receptor β for genipin derivative-induced optic nerve regeneration in adult rat retina.","23940731","genipin","Receptors, Retinoic Acid"]
["genipin","retinoic acid receptor beta_antag","retinoic acid receptor beta","antag","23940731",2013,"Requirement of retinoic acid receptor β for genipin derivative-induced optic nerve regeneration in adult rat retina.","23940731","genipin","retinoic acid receptor beta"]
["Genistein","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","12844379",2003,"The red clover (Trifolium pratense) isoflavone biochanin A modulates the biotransformation pathways of 7,12-dimethylbenz[a]anthracene.","12844379","Genistein","Cytochrome P-450 CYP1A1"]
["Genistein","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","16889690",2006,"Effective chemopreventive activity of genistein against human breast cancer cells.","16889690","Genistein","Cytochrome P-450 CYP1A1"]
["Genistein","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","16903077",2006,"Effect of biochanin A on the aryl hydrocarbon receptor and cytochrome P450 1A1 in MCF-7 human breast carcinoma cells.","16903077","Genistein","Cytochrome P-450 CYP1A1"]
["Genistein","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","19490995",2009,"Impact of genistein on maturation of mouse oocytes, fertilization, and fetal development.","19490995","Genistein","Receptors, Retinoic Acid"]
["genistin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","10597900",1999,"Inhibition of CYP1A1 enzyme activity in mouse hepatoma cell culture by soybean isoflavones.","10597900","genistin","Cytochrome P-450 CYP1A1"]
["Glucose","Retinoblastoma-Like Protein p130_antag","Retinoblastoma-Like Protein p130","antag","12631140",2003,"High glucose levels inhibit focal adhesion kinase-mediated wound healing of rat peritoneal mesothelial cells.","12631140","Glucose","Retinoblastoma-Like Protein p130"]
["Glucose","Retinoid X Receptors_ag","Retinoid X Receptors","ag","24391011",2013,"RXR agonists inhibit high glucose-induced upregulation of inflammation by suppressing activation of the NADPH oxidase-nuclear factor-κB pathway in human endothelial cells.","24391011","Glucose","Retinoid X Receptors"]
["Glucose","Secretin_antag","Secretin","antag","5581330",1971,"Influence of intrajejunal glucose on pancreatic exocrine function in man.","5581330","Glucose","Secretin"]
["Glycerol","retinol-palmitate esterase_antag","retinol-palmitate esterase","antag","6743674",1984,"Inhibition of rat liver retinyl palmitate hydrolase activity by ether analogs of cholesteryl esters and acylglycerides.","6743674","Glycerol","retinol-palmitate esterase"]
["Gossypol","Retinoblastoma Protein_antag","Retinoblastoma Protein","antag","9218727",1997,"Gossypol inhibition of mitosis, cyclin D1 and Rb protein in human mammary cancer cells and cyclin-D1 transfected human fibrosarcoma cells.","9218727","Gossypol","Retinoblastoma Protein"]
["Griseofulvin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","9548566",1998,"Inhibition of PPAR alpha/RXR alpha-mediated direct hyperplasia pathways during griseofulvin-induced hepatocarcinogenesis.","9548566","Griseofulvin","Receptors, Retinoic Acid"]
["Griseofulvin","retinoic acid receptor alpha_antag","retinoic acid receptor alpha","antag","9548566",1998,"Inhibition of PPAR alpha/RXR alpha-mediated direct hyperplasia pathways during griseofulvin-induced hepatocarcinogenesis.","9548566","Griseofulvin","retinoic acid receptor alpha"]
["Griseofulvin","retinoic acid receptor beta_antag","retinoic acid receptor beta","antag","9548566",1998,"Inhibition of PPAR alpha/RXR alpha-mediated direct hyperplasia pathways during griseofulvin-induced hepatocarcinogenesis.","9548566","Griseofulvin","retinoic acid receptor beta"]
["Griseofulvin","retinoic acid receptor gamma_antag","retinoic acid receptor gamma","antag","9548566",1998,"Inhibition of PPAR alpha/RXR alpha-mediated direct hyperplasia pathways during griseofulvin-induced hepatocarcinogenesis.","9548566","Griseofulvin","retinoic acid receptor gamma"]
["Griseofulvin","Retinoid X Receptors_antag","Retinoid X Receptors","antag","9548566",1998,"Inhibition of PPAR alpha/RXR alpha-mediated direct hyperplasia pathways during griseofulvin-induced hepatocarcinogenesis.","9548566","Griseofulvin","Retinoid X Receptors"]
["GSK 461364","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","22248814",2011,"Pooled shRNA screen for sensitizers to inhibition of the mitotic regulator polo-like kinase (PLK1).","22248814","GSK 461364","Receptors, Retinoic Acid"]
["GSK 461364","retinoic acid receptor alpha_antag","retinoic acid receptor alpha","antag","22248814",2011,"Pooled shRNA screen for sensitizers to inhibition of the mitotic regulator polo-like kinase (PLK1).","22248814","GSK 461364","retinoic acid receptor alpha"]
["Guanine","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","8013273",1994,"Use of rat and human in vitro systems to assess the effectiveness and enzymology of deoxyguanine analogs as prodrugs of an antiviral agent.","8013273","Guanine","Aldehyde Oxidoreductases"]
["Haloperidol","Secretin_antag","Secretin","antag","6443810",1984,"[Effect of dopamine and haloperidol on the exocrine function of the rat pancreas in vivo].","6443810","Haloperidol","Secretin"]
["helenalin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","2512929",1989,"In vitro inhibition of mouse hepatic mixed-function oxidase enzymes by helenalin and alantolactone.","2512929","helenalin","Cytochrome P-450 CYP1A1"]
["Hexobarbital","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","2438009",1987,"Effects of aldehyde dehydrogenase inhibitors on hexobarbital sensitivity and neuroamine metabolism in rat brain.","2438009","Hexobarbital","Aldehyde Oxidoreductases"]
["Histamine","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","466870",1979,"Liver alcohol and aldehyde dehydrogenase: inhibition and potentiation by histamine agonists and antagonists.","466870","Histamine","Aldehyde Oxidoreductases"]
["Histamine","Secretin_antag","Secretin","antag","5121379",1971,"The kinetics of inhibition by fat of histamine-stimulated gastric acid.","5121379","Histamine","Secretin"]
["honokiol","Retinoid X Receptor beta_ag","Retinoid X Receptor beta","ag","20606297",2010,"Honokiol increases ABCA1 expression level by activating retinoid X receptor beta.","20606297","honokiol","Retinoid X Receptor beta"]
["honokiol","Retinoid X Receptors_ag","Retinoid X Receptors","ag","20695472",2010,"Identification of a naturally occurring rexinoid, honokiol, that activates the retinoid X receptor.","20695472","honokiol","Retinoid X Receptors"]
["honokiol","Retinoid X Receptors_ag","Retinoid X Receptors","ag","22223330",2012,"A naturally occurring rexinoid, honokiol, can serve as a regulator of various retinoid x receptor heterodimers.","22223330","honokiol","Retinoid X Receptors"]
["HX 630","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","24916544",2014,"Cooperative therapeutic action of retinoic acid receptor and retinoid x receptor agonists in a mouse model of Alzheimer's disease.","24916544","HX 630","Receptors, Retinoic Acid"]
["HX 630","Retinoid X Receptors_ag","Retinoid X Receptors","ag","16963076",2006,"A new RXR agonist, HX630, suppresses intimal hyperplasia in a mouse blood flow cessation model.","16963076","HX 630","Retinoid X Receptors"]
["HX 630","Retinoid X Receptors_ag","Retinoid X Receptors","ag","24916544",2014,"Cooperative therapeutic action of retinoic acid receptor and retinoid x receptor agonists in a mouse model of Alzheimer's disease.","24916544","HX 630","Retinoid X Receptors"]
["Hydralazine","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","3841000",1985,"Hydralazine: a potent inhibitor of aldehyde oxidase activity in vitro and in vivo.","3841000","Hydralazine","Aldehyde Oxidoreductases"]
["Hydrogen Peroxide","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","9705204",1998,"Suppression of CYP1A1 transcription by H2O2 is mediated by xenobiotic-response element.","9705204","Hydrogen Peroxide","Cytochrome P-450 CYP1A1"]
["Hydrogen Peroxide","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","11278809",2001,"Selective roles of retinoic acid receptor and retinoid x receptor in the suppression of apoptosis by all-trans-retinoic acid.","11278809","Hydrogen Peroxide","Receptors, Retinoic Acid"]
["Hydrogen Peroxide","Retinoid X Receptors_antag","Retinoid X Receptors","antag","11278809",2001,"Selective roles of retinoic acid receptor and retinoid x receptor in the suppression of apoptosis by all-trans-retinoic acid.","11278809","Hydrogen Peroxide","Retinoid X Receptors"]
["Hydroxyacetylaminofluorene","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","3741414",1986,"N-hydroxy-2-acetylaminofluorene as effective inhibitor of aldehyde oxidase.","3741414","Hydroxyacetylaminofluorene","Aldehyde Oxidoreductases"]
["IIF compound","Retinoid X Receptors_ag","Retinoid X Receptors","ag","19288012",2009,"Enhanced effects of PPARgamma ligands and RXR selective retinoids in combination to inhibit migration and invasiveness in cancer cells.","19288012","IIF compound","Retinoid X Receptors"]
["imperatorin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","11159744",2001,"Oral administration of naturally occurring coumarins leads to altered phase I and II enzyme activities and reduced DNA adduct formation by polycyclic aromatic hydrocarbons in various tissues of SENCAR mice.","11159744","imperatorin","Cytochrome P-450 CYP1A1"]
["indole-3-carbinol","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","18486294",2008,"Inhibitory effects of a dietary phytochemical 3,3'-diindolylmethane on the phenobarbital-induced hepatic CYP mRNA expression and CYP-catalyzed reactions in female rats.","18486294","indole-3-carbinol","Cytochrome P-450 CYP1A1"]
["indole-3-carbinol","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","7590528",1995,"Induction of hepatic CYP1A by indole-3-carbinol in protection against aflatoxin B1 hepatocarcinogenesis in rainbow trout.","7590528","indole-3-carbinol","Cytochrome P-450 CYP1A1"]
["indole-3-carbinol","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","8866829",1996,"Indole-3-carbinol and diindolylmethane as aryl hydrocarbon (Ah) receptor agonists and antagonists in T47D human breast cancer cells.","8866829","indole-3-carbinol","Cytochrome P-450 CYP1A1"]
["indolo(3,2-b)carbazole","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","1330548",1992,"Certain tryptophan photoproducts are inhibitors of cytochrome P450-dependent mutagenicity.","1330548","indolo(3,2-b)carbazole","Cytochrome P-450 CYP1A1"]
["indolo(3,2-b)carbazole","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","7673247",1995,"Regulation of CYP1A1 by indolo[3,2-b]carbazole in murine hepatoma cells.","7673247","indolo(3,2-b)carbazole","Cytochrome P-450 CYP1A1"]
["Indomethacin",{"$f":"C963&\"_\"&D963","v":"Secretin_antag"},"Secretin","antag","7769193",1995,"Acid secretion during indomethacin therapy. Effect of misoprostol.","7769193","Indomethacin","Secretin"]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  I964,I964)","v":"Iodoacetamide"},"Aldehyde Oxidoreductases_antag",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  J964,J964)","v":"Aldehyde Oxidoreductases"},"antag",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & H964,H964)","v":"7424721"},1980,"On the interaction of human liver aldehyde dehydrogenase E1 isoenzyme with disulfiram and iodoacetamide.","7424721","Iodoacetamide","Aldehyde Oxidoreductases"]
["isopimpinellin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","11159744",2001,"Oral administration of naturally occurring coumarins leads to altered phase I and II enzyme activities and reduced DNA adduct formation by polycyclic aromatic hydrocarbons in various tissues of SENCAR mice.","11159744","isopimpinellin","Cytochrome P-450 CYP1A1"]
["isoquercitrin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","12787821",2003,"Inhibition of clastogenicity of benzo[a]pyrene and of its trans-7,8-dihydrodiol in mice in vivo by fruits, vegetables, and flavonoids.","12787821","isoquercitrin","Cytochrome P-450 CYP1A1"]
["isosafrole","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","9105404",1997,"Distinction of CYP1A1 and CYP1A2 activity by selective inhibition using fluvoxamine and isosafrole.","9105404","isosafrole","Cytochrome P-450 CYP1A1"]
["Isotretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","12814338",2003,"Isotretinoin use and subsequent depression and suicide: presenting the evidence.","12814338","Isotretinoin","Receptors, Retinoic Acid"]
["Isotretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","18445226",2008,"13-cis-retinoic acid alters the cellular morphology of slice-cultured serotonergic neurons in the rat.","18445226","Isotretinoin","Receptors, Retinoic Acid"]
["Isotretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","23088909",2012,"Synthesis of retinoid enhancers based on 2-aminobenzothiazoles for anti-cancer therapy.","23088909","Isotretinoin","Receptors, Retinoic Acid"]
["Isotretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","12139723",2002,"Superior effect of 9-cis retinoic acid (RA) compared with all-trans RA and 13-cis RA on the inhibition of clonogenic cell growth and the induction of apoptosis in OCI/AML-2 subclones: is the p53 pathway involved?","12139723","Isotretinoin","Receptors, Retinoic Acid"]
["Isotretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","18445226",2008,"13-cis-retinoic acid alters the cellular morphology of slice-cultured serotonergic neurons in the rat.","18445226","Isotretinoin","Receptors, Retinoic Acid"]
["Isotretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","8921345",1996,"Retinoid-induced hypertriglyceridemia in rats is mediated by retinoic acid receptors.","8921345","Isotretinoin","Receptors, Retinoic Acid"]
["Isotretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","8937896",1996,"Retinoid-induced epiphyseal plate closure in guinea pigs.","8937896","Isotretinoin","Receptors, Retinoic Acid"]
["Isotretinoin","retinoic acid receptor, beta2, human_ag","retinoic acid receptor, beta2, human","ag","23088909",2012,"Synthesis of retinoid enhancers based on 2-aminobenzothiazoles for anti-cancer therapy.","23088909","Isotretinoin","retinoic acid receptor, beta2, human"]
["Isotretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","18445226",2008,"13-cis-retinoic acid alters the cellular morphology of slice-cultured serotonergic neurons in the rat.","18445226","Isotretinoin","Retinoid X Receptors"]
["Isotretinoin","Retinoid X Receptors_antag","Retinoid X Receptors","antag","18445226",2008,"13-cis-retinoic acid alters the cellular morphology of slice-cultured serotonergic neurons in the rat.","18445226","Isotretinoin","Retinoid X Receptors"]
["Isotretinoin","retinol dehydrogenase_antag","retinol dehydrogenase","antag","10606761",2000,"Substrate specificities and 13-cis-retinoic acid inhibition of human, mouse and bovine cis-retinol dehydrogenases.","10606761","Isotretinoin","retinol dehydrogenase"]
["Isotretinoin","retinol dehydrogenase 5_antag","retinol dehydrogenase 5","antag","10606761",2000,"Substrate specificities and 13-cis-retinoic acid inhibition of human, mouse and bovine cis-retinol dehydrogenases.","10606761","Isotretinoin","retinol dehydrogenase 5"]
["Itraconazole","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","17283379",2007,"Induction of cytochrome P450 1A1 by ketoconazole and itraconazole but not fluconazole in murine and human hepatoma cell lines.","17283379","Itraconazole","Cytochrome P-450 CYP1A1"]
["IY 80843","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","7576828",1995,"Inhibitory effects of H2-receptor antagonists on cytochrome P450 in male ICR mice.","7576828","IY 80843","Cytochrome P-450 CYP1A1"]
["IY 80845","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","7576828",1995,"Inhibitory effects of H2-receptor antagonists on cytochrome P450 in male ICR mice.","7576828","IY 80845","Cytochrome P-450 CYP1A1"]
["jatrorrhizine","CYP1A1 protein, human_antag","CYP1A1 protein, human","antag","23886934",2013,"Inhibition of CYP1 by berberine, palmatine, and jatrorrhizine: selectivity, kinetic characterization, and molecular modeling.","23886934","jatrorrhizine","CYP1A1 protein, human"]
["jatrorrhizine","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","23886934",2013,"Inhibition of CYP1 by berberine, palmatine, and jatrorrhizine: selectivity, kinetic characterization, and molecular modeling.","23886934","jatrorrhizine","Cytochrome P-450 CYP1A1"]
["kahweol","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","12804590",2003,"Coffee diterpenes prevent benzo[a]pyrene genotoxicity in rat and human culture systems.","12804590","kahweol","Cytochrome P-450 CYP1A1"]
["Ketoconazole","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","10064566",1999,"Cytochrome P-450 1A1 expression in human small bowel: interindividual variation and inhibition by ketoconazole.","10064566","Ketoconazole","Cytochrome P-450 CYP1A1"]
["Ketoconazole","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","17283379",2007,"Induction of cytochrome P450 1A1 by ketoconazole and itraconazole but not fluconazole in murine and human hepatoma cell lines.","17283379","Ketoconazole","Cytochrome P-450 CYP1A1"]
["Ketoconazole","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","3263862",1988,"Inhibition of human hepatic and placental xenobiotic monooxygenases by imidazole antimycotics.","3263862","Ketoconazole","Cytochrome P-450 CYP1A1"]
["Ketoconazole","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","9077483",1997,"The retinoid X receptor agonist 9-cis-retinoic acid and the 24-hydroxylase inhibitor ketoconazole increase activity of 1,25-dihydroxyvitamin D3 in human skin in vivo.","9077483","Ketoconazole","Receptors, Retinoic Acid"]
["Ketoconazole","Retinoid X Receptors_ag","Retinoid X Receptors","ag","9077483",1997,"The retinoid X receptor agonist 9-cis-retinoic acid and the 24-hydroxylase inhibitor ketoconazole increase activity of 1,25-dihydroxyvitamin D3 in human skin in vivo.","9077483","Ketoconazole","Retinoid X Receptors"]
["KN 93","Retinoblastoma Protein_antag","Retinoblastoma Protein","antag","9596994",1998,"CaMK-II inhibition reduces cyclin D1 levels and enhances the association of p27kip1 with Cdk2 to cause G1 arrest in NIH 3T3 cells.","9596994","KN 93","Retinoblastoma Protein"]
["latanoprost","Retinoid X Receptor alpha_antag","Retinoid X Receptor alpha","antag","23989723",2013,"Latanoprost effectively ameliorates glucose and lipid disorders in db/db and ob/ob mice.","23989723","latanoprost","Retinoid X Receptor alpha"]
["LE 135","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","17615267",2007,"Pharmacological regulation of adult stem cells: chondrogenesis can be induced using a synthetic inhibitor of the retinoic acid receptor.","17615267","LE 135","Receptors, Retinoic Acid"]
["LE 135","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","21763841",2011,"Establishment of a rescue program for anorectal malformations induced by retinoic acid in mice.","21763841","LE 135","Receptors, Retinoic Acid"]
["LE 135","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","24308840",2014,"LE135, a retinoid acid receptor antagonist, produces pain through direct activation of TRP channels.","24308840","LE 135","Receptors, Retinoic Acid"]
["LE 135","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","24851851",2014,"Regulating chondrogenesis of human mesenchymal stromal cells with a retinoic Acid receptor-Beta inhibitor: differential sensitivity of chondral versus osteochondral development.","24851851","LE 135","Receptors, Retinoic Acid"]
["LE 135","retinoic acid receptor beta_antag","retinoic acid receptor beta","antag","17615267",2007,"Pharmacological regulation of adult stem cells: chondrogenesis can be induced using a synthetic inhibitor of the retinoic acid receptor.","17615267","LE 135","retinoic acid receptor beta"]
["LE 135","retinoic acid receptor beta_antag","retinoic acid receptor beta","antag","24851851",2014,"Regulating chondrogenesis of human mesenchymal stromal cells with a retinoic Acid receptor-Beta inhibitor: differential sensitivity of chondral versus osteochondral development.","24851851","LE 135","retinoic acid receptor beta"]
["LE 135","Retinoid X Receptor beta_antag","Retinoid X Receptor beta","antag","21308729",2011,"The role of retinoic acid receptor inhibitor LE135 on the osteochondral differentiation of human bone marrow mesenchymal stem cells.","21308729","LE 135","Retinoid X Receptor beta"]
["LE 540","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","22000589",2011,"Retinoic acid receptor antagonist LE540 attenuates wakefulness via the dopamine D1 receptor in mice.","22000589","LE 540","Receptors, Retinoic Acid"]
["lead acetate","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","18439880",2008,"Effects of Cu(2+) and Pb(2+) on different fish species: liver cytochrome P450-dependent monooxygenase activities and FTIR spectra.","18439880","lead acetate","Cytochrome P-450 CYP1A1"]
["Leukotriene B4","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","19264469",2009,"Effects of leukotriene B4 and prostaglandin E2 on the differentiation of murine Foxp3+ T regulatory cells and Th17 cells.","19264469","Leukotriene B4","Receptors, Retinoic Acid"]
["Leukotriene B4","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","19264469",2009,"Effects of leukotriene B4 and prostaglandin E2 on the differentiation of murine Foxp3+ T regulatory cells and Th17 cells.","19264469","Leukotriene B4","Receptors, Retinoic Acid"]
["levan","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","23618309",2013,"Scaling up, characterization of levan and its inhibitory role in carcinogenesis initiation stage'.","23618309","levan","Cytochrome P-450 CYP1A1"]
["LG 100268","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","10333046",1999,"The RXR agonist LG100268 causes hepatomegaly, improves glycaemic control and decreases cardiovascular risk and cachexia in diabetic mice suffering from pancreatic beta-cell dysfunction.","10333046","LG 100268","Receptors, Retinoic Acid"]
["LG 100268","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","10951538",2000,"Retinoid X receptor agonists have anti-obesity effects and improve insulin sensitivity in Zucker fa/fa rats.","10951538","LG 100268","Receptors, Retinoic Acid"]
["LG 100268","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","11259621",2001,"Differential effects of rexinoids and thiazolidinediones on metabolic gene expression in diabetic rodents.","11259621","LG 100268","Receptors, Retinoic Acid"]
["LG 100268","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","11463859",2001,"The rexinoid LG100754 is a novel RXR:PPARgamma agonist and decreases glucose levels in vivo.","11463859","LG 100268","Receptors, Retinoic Acid"]
["LG 100268","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","11782480",2002,"The structural basis for the specificity of retinoid-X receptor-selective agonists: new insights into the role of helix H12.","11782480","LG 100268","Receptors, Retinoic Acid"]
["LG 100268","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","12130551",2002,"Mechanism of selective retinoid X receptor agonist-induced hypothyroidism in the rat.","12130551","LG 100268","Receptors, Retinoic Acid"]
["LG 100268","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","23441952",2013,"Differential effects of retinoids and inhibitors of ERK and p38 signaling on adipogenic and myogenic differentiation of P19 stem cells.","23441952","LG 100268","Receptors, Retinoic Acid"]
["LG 100268","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","8837780",1996,"Activation of specific RXR heterodimers by an antagonist of RXR homodimers.","8837780","LG 100268","Receptors, Retinoic Acid"]
["LG 100268","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","23441952",2013,"Differential effects of retinoids and inhibitors of ERK and p38 signaling on adipogenic and myogenic differentiation of P19 stem cells.","23441952","LG 100268","Receptors, Retinoic Acid"]
["LG 100268","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","8837780",1996,"Activation of specific RXR heterodimers by an antagonist of RXR homodimers.","8837780","LG 100268","Receptors, Retinoic Acid"]
["LG 100268","Retinoid X Receptors_ag","Retinoid X Receptors","ag","10333046",1999,"The RXR agonist LG100268 causes hepatomegaly, improves glycaemic control and decreases cardiovascular risk and cachexia in diabetic mice suffering from pancreatic beta-cell dysfunction.","10333046","LG 100268","Retinoid X Receptors"]
["LG 100268","Retinoid X Receptors_ag","Retinoid X Receptors","ag","10951538",2000,"Retinoid X receptor agonists have anti-obesity effects and improve insulin sensitivity in Zucker fa/fa rats.","10951538","LG 100268","Retinoid X Receptors"]
["LG 100268","Retinoid X Receptors_ag","Retinoid X Receptors","ag","11259621",2001,"Differential effects of rexinoids and thiazolidinediones on metabolic gene expression in diabetic rodents.","11259621","LG 100268","Retinoid X Receptors"]
["LG 100268","Retinoid X Receptors_ag","Retinoid X Receptors","ag","11463859",2001,"The rexinoid LG100754 is a novel RXR:PPARgamma agonist and decreases glucose levels in vivo.","11463859","LG 100268","Retinoid X Receptors"]
["LG 100268","Retinoid X Receptors_ag","Retinoid X Receptors","ag","11782480",2002,"The structural basis for the specificity of retinoid-X receptor-selective agonists: new insights into the role of helix H12.","11782480","LG 100268","Retinoid X Receptors"]
["LG 100268","Retinoid X Receptors_ag","Retinoid X Receptors","ag","12130551",2002,"Mechanism of selective retinoid X receptor agonist-induced hypothyroidism in the rat.","12130551","LG 100268","Retinoid X Receptors"]
["LG 100268","Retinoid X Receptors_ag","Retinoid X Receptors","ag","17869331",2007,"Retinoid receptor-specific agonists regulate bovine in vitro early embryonic development, differentiation and expression of genes related to cell cycle arrest and apoptosis.","17869331","LG 100268","Retinoid X Receptors"]
["LG 100268","Retinoid X Receptors_ag","Retinoid X Receptors","ag","19007552",2008,"Development and quality of bovine morulae cultured in serum-free medium with specific retinoid receptor agonists.","19007552","LG 100268","Retinoid X Receptors"]
["LG 100268","Retinoid X Receptors_ag","Retinoid X Receptors","ag","23441952",2013,"Differential effects of retinoids and inhibitors of ERK and p38 signaling on adipogenic and myogenic differentiation of P19 stem cells.","23441952","LG 100268","Retinoid X Receptors"]
["LG 100268","Retinoid X Receptors_ag","Retinoid X Receptors","ag","25217640",2014,"Amyloid-β pathology and APOE genotype modulate retinoid X receptor agonist activity in vivo.","25217640","LG 100268","Retinoid X Receptors"]
["LG 100268","Retinoid X Receptors_ag","Retinoid X Receptors","ag","8837780",1996,"Activation of specific RXR heterodimers by an antagonist of RXR homodimers.","8837780","LG 100268","Retinoid X Receptors"]
["LG 100268","Retinoid X Receptors_antag","Retinoid X Receptors","antag","23441952",2013,"Differential effects of retinoids and inhibitors of ERK and p38 signaling on adipogenic and myogenic differentiation of P19 stem cells.","23441952","LG 100268","Retinoid X Receptors"]
["LG 100268",{"$f":"C1027&\"_\"&D1027","v":"Retinoid X Receptors_antag"},"Retinoid X Receptors","antag","8837780",1996,"Activation of specific RXR heterodimers by an antagonist of RXR homodimers.","8837780","LG 100268","Retinoid X Receptors"]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  I1028,I1028)","v":"LG 100324"},"Receptors, Retinoic Acid_ag",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  J1028,J1028)","v":"Receptors, Retinoic Acid"},"ag",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & H1028,H1028)","v":"10951538"},2000,"Retinoid X receptor agonists have anti-obesity effects and improve insulin sensitivity in Zucker fa/fa rats.","10951538","LG 100324","Receptors, Retinoic Acid"]
["LG 100324","Retinoid X Receptors_ag","Retinoid X Receptors","ag","10951538",2000,"Retinoid X receptor agonists have anti-obesity effects and improve insulin sensitivity in Zucker fa/fa rats.","10951538","LG 100324","Retinoid X Receptors"]
["LG 100754","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","11463859",2001,"The rexinoid LG100754 is a novel RXR:PPARgamma agonist and decreases glucose levels in vivo.","11463859","LG 100754","Receptors, Retinoic Acid"]
["LG 100754","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","8837780",1996,"Activation of specific RXR heterodimers by an antagonist of RXR homodimers.","8837780","LG 100754","Receptors, Retinoic Acid"]
["LG 100754","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","8837780",1996,"Activation of specific RXR heterodimers by an antagonist of RXR homodimers.","8837780","LG 100754","Receptors, Retinoic Acid"]
["LG 100754","Retinoid X Receptors_ag","Retinoid X Receptors","ag","11463859",2001,"The rexinoid LG100754 is a novel RXR:PPARgamma agonist and decreases glucose levels in vivo.","11463859","LG 100754","Retinoid X Receptors"]
["LG 100754","Retinoid X Receptors_ag","Retinoid X Receptors","ag","8837780",1996,"Activation of specific RXR heterodimers by an antagonist of RXR homodimers.","8837780","LG 100754","Retinoid X Receptors"]
["LG 100754","Retinoid X Receptors_antag","Retinoid X Receptors","antag","8837780",1996,"Activation of specific RXR heterodimers by an antagonist of RXR homodimers.","8837780","LG 100754","Retinoid X Receptors"]
["LG 101208","Retinoid X Receptors_antag","Retinoid X Receptors","antag","21458528",2011,"A rexinoid antagonist increases the hypothalamic-pituitary-thyroid set point in mice and thyrotrope cells.","21458528","LG 101208","Retinoid X Receptors"]
["LG 268","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","11782480",2002,"The structural basis for the specificity of retinoid-X receptor-selective agonists: new insights into the role of helix H12.","11782480","LG 268","Receptors, Retinoic Acid"]
["LG 268","Retinoid X Receptors_ag","Retinoid X Receptors","ag","11782480",2002,"The structural basis for the specificity of retinoid-X receptor-selective agonists: new insights into the role of helix H12.","11782480","LG 268","Retinoid X Receptors"]
["liarozole","retinoic acid 4-hydroxylase_antag","retinoic acid 4-hydroxylase","antag","11870544",2002,"Inhibition of all-TRANS-retinoic acid metabolism by R116010 induces antitumour activity.","11870544","liarozole","retinoic acid 4-hydroxylase"]
["liarozole","retinoic acid 4-hydroxylase_antag","retinoic acid 4-hydroxylase","antag","18608743",2009,"Design and synthesis of substituted imidazole and triazole N-phenylbenzo[d]oxazolamine inhibitors of retinoic acid metabolizing enzyme CYP26.","18608743","liarozole","retinoic acid 4-hydroxylase"]
["liarozole","retinoic acid 4-hydroxylase_antag","retinoic acid 4-hydroxylase","antag","8757760",1996,"Liarozole inhibits human epidermal retinoic acid 4-hydroxylase activity and differentially augments human skin responses to retinoic acid and retinol in vivo.","8757760","liarozole","retinoic acid 4-hydroxylase"]
["liarozole","retinoic acid 4-hydroxylase_antag","retinoic acid 4-hydroxylase","antag","9871667",1998,"Synthesis of LIAZAL, a retinoic acid metabolism blocking agent (RAMBA) with potential clinical applications in oncology and dermatology.","9871667","liarozole","retinoic acid 4-hydroxylase"]
["Lidocaine","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","8689940",1995,"Relative potency of mexiletine, lidocaine, and tocainide as inhibitors of rat liver CYP1A1 activity.","8689940","Lidocaine","Cytochrome P-450 CYP1A1"]
["luffariellolide","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","22642567",2012,"Revealing a natural marine product as a novel agonist for retinoic acid receptors with a unique binding mode and inhibitory effects on cancer cells.","22642567","luffariellolide","Receptors, Retinoic Acid"]
["luffariellolide","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","22835216",2012,"What lies beneath: natural products from marine organisms as nuclear receptor modulators.","22835216","luffariellolide","Receptors, Retinoic Acid"]
["luffariellolide","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","22642567",2012,"Revealing a natural marine product as a novel agonist for retinoic acid receptors with a unique binding mode and inhibitory effects on cancer cells.","22642567","luffariellolide","retinoic acid receptor alpha"]
["luffariellolide","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","22835216",2012,"What lies beneath: natural products from marine organisms as nuclear receptor modulators.","22835216","luffariellolide","retinoic acid receptor alpha"]
["luffariellolide","retinoic acid receptor beta_ag","retinoic acid receptor beta","ag","22642567",2012,"Revealing a natural marine product as a novel agonist for retinoic acid receptors with a unique binding mode and inhibitory effects on cancer cells.","22642567","luffariellolide","retinoic acid receptor beta"]
["luotonin A","CYP1A1 protein, human_antag","CYP1A1 protein, human","antag","23263815",2012,"In vitro inhibitory effect of luotonin A on human CYP1A.","23263815","luotonin A","CYP1A1 protein, human"]
["luotonin A","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","23263815",2012,"In vitro inhibitory effect of luotonin A on human CYP1A.","23263815","luotonin A","Cytochrome P-450 CYP1A1"]
["lycopene","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","20400267",2010,"The carotenoid lycopene differentially regulates phase I and II enzymes in dimethylbenz[a]anthracene-induced MCF-7 cells.","20400267","lycopene","Cytochrome P-450 CYP1A1"]
["Magnesium","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","6634825",1983,"Effects of magnesium and calcium on mitochondrial and cytosolic liver aldehyde dehydrogenases.","6634825","Magnesium","Aldehyde Oxidoreductases"]
["Magnesium","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","6838823",1983,"Inhibition of the dehydrogenase activity of sheep liver cytoplasmic aldehyde dehydrogenase by magnesium ions.","6838823","Magnesium","Aldehyde Oxidoreductases"]
["Magnesium","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","7138510",1982,"Effects of Mg2+, Ca2+ and Mn2+ on sheep liver cytoplasmic aldehyde dehydrogenase.","7138510","Magnesium","Aldehyde Oxidoreductases"]
["Magnesium Chloride","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","6838823",1983,"Inhibition of the dehydrogenase activity of sheep liver cytoplasmic aldehyde dehydrogenase by magnesium ions.","6838823","Magnesium Chloride","Aldehyde Oxidoreductases"]
["magnolol","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","16884943",2006,"In vitro anti-mutagenic effect of magnolol against direct and indirect mutagens.","16884943","magnolol","Cytochrome P-450 CYP1A1"]
["magnolol","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","19571387",2009,"Anti-clastogenic effect of magnolol-containing Hange-koboku-to, Dai-joki-to, Goshaku-san, and Magnoliae Cortex on benzo(a)pyrene-induced clastogenicity in mice.","19571387","magnolol","Cytochrome P-450 CYP1A1"]
["magnolol","Retinoid X Receptor alpha_ag","Retinoid X Receptor alpha","ag","22140563",2011,"Molecular determinants of magnolol targeting both RXRα and PPARγ.","22140563","magnolol","Retinoid X Receptor alpha"]
["malassezin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","11354679",2001,"Malassezin--A novel agonist of the arylhydrocarbon receptor from the yeast Malassezia furfur.","11354679","malassezin","Cytochrome P-450 CYP1A1"]
["Malondialdehyde","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","7157414",1982,"Inhibition of mitochondrial aldehyde dehydrogenase by malondialdehyde.","7157414","Malondialdehyde","Aldehyde Oxidoreductases"]
["Manganese","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","7138510",1982,"Effects of Mg2+, Ca2+ and Mn2+ on sheep liver cytoplasmic aldehyde dehydrogenase.","7138510","Manganese","Aldehyde Oxidoreductases"]
["Mangifera indica extract","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","22865094",2012,"Antimutagenic properties of Mangifera indica L. stem bark extract and evaluation of its effects on hepatic CYP1A1.","22865094","Mangifera indica extract","Cytochrome P-450 CYP1A1"]
["Materia Medica","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","25090712",2014,"[Effect of retinociacdi combined extracts from testudinis carapacis et plastri on proliferating in MSCs and its mechanism].","25090712","Materia Medica","Receptors, Retinoic Acid"]
["Melatonin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","10862820",2000,"2,3,7,8-Tetrachlorodibenzo-p-dioxin alters melatonin metabolism in fish hepatocytes.","10862820","Melatonin","Cytochrome P-450 CYP1A1"]
["Melatonin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","12662353",2003,"Melatonin inhibits growth of diethylstilbestrol-induced prolactin-secreting pituitary tumor in vitro: possible involvement of nuclear RZR/ROR receptors.","12662353","Melatonin","Receptors, Retinoic Acid"]
["Melatonin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","12662353",2003,"Melatonin inhibits growth of diethylstilbestrol-induced prolactin-secreting pituitary tumor in vitro: possible involvement of nuclear RZR/ROR receptors.","12662353","Melatonin","Receptors, Retinoic Acid"]
["Mescaline","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","1129346",1975,"Discriminative stimulus properties of mescaline: mescaline or metabolite?","1129346","Mescaline","Aldehyde Oxidoreductases"]
["meso-zeaxanthin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","23909729",2013,"Anticarcinogenic activity of meso-zeaxanthin in rodents and its possible mechanism of action.","23909729","meso-zeaxanthin","Cytochrome P-450 CYP1A1"]
["Metformin","CYP1A1 protein, human_antag","CYP1A1 protein, human","antag","25110054",2014,"Metformin suppresses CYP1A1 and CYP1B1 expression in breast cancer cells by down-regulating aryl hydrocarbon receptor expression.","25110054","Metformin","CYP1A1 protein, human"]
["Metformin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","25110054",2014,"Metformin suppresses CYP1A1 and CYP1B1 expression in breast cancer cells by down-regulating aryl hydrocarbon receptor expression.","25110054","Metformin","Cytochrome P-450 CYP1A1"]
["Metformin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","25697376",2015,"Metformin inhibits 7,12-dimethylbenz[a]anthracene-induced breast carcinogenesis and adduct formation in human breast cells by inhibiting the cytochrome P4501A1/aryl hydrocarbon receptor signaling pathway.","25697376","Metformin","Cytochrome P-450 CYP1A1"]
["Methadone","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","8117328",1994,"Methadone: a potent inhibitor of rat liver aldehyde oxidase.","8117328","Methadone","Aldehyde Oxidoreductases"]
["Methamphetamine","Retinoid X Receptors_ag","Retinoid X Receptors","ag","17019405",2007,"Peroxisome proliferator-activated receptor gamma activation relieves expression of behavioral sensitization to methamphetamine in mice.","17019405","Methamphetamine","Retinoid X Receptors"]
["Methanol","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","1029022",1976,"Protection against toxic effects of formaldehyde in vitro, and of methanol or formaldehyde in vivo, by subsequent administration of SH reagents.","1029022","Methanol","Aldehyde Oxidoreductases"]
["Methoxychlor","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","8114062",1993,"Reversible and time-dependent inhibition of the hepatic cytochrome P450 steroidal hydroxylases by the proestrogenic pesticide methoxychlor in rat and human.","8114062","Methoxychlor","Cytochrome P-450 CYP1A1"]
["methyl 3-(4-(6-bromopyridin-3-ylamino)phenyl)-3-(1H-imidazol-1-yl)-2,2-dimethylpropanoate","retinoic acid 4-hydroxylase_antag","retinoic acid 4-hydroxylase","antag","22989911",2012,"Synthesis and CYP26A1 inhibitory activity of novel methyl 3-[4-(arylamino)phenyl]-3-(azole)-2,2-dimethylpropanoates.","22989911","methyl 3-(4-(6-bromopyridin-3-ylamino)phenyl)-3-(1H-imidazol-1-yl)-2,2-dimethylpropanoate","retinoic acid 4-hydroxylase"]
["methyl 4-((2,3-dihydro-2,2,4,4-teetramethyl-2H-1-benzothiopyran-6-yl)carbamoyl)benzoate","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","10543887",1999,"Heteroarotinoids inhibit head and neck cancer cell lines in vitro and in vivo through both RAR and RXR retinoic acid receptors.","10543887","methyl 4-((2,3-dihydro-2,2,4,4-teetramethyl-2H-1-benzothiopyran-6-yl)carbamoyl)benzoate","Receptors, Retinoic Acid"]
["methyl 4-((2,3-dihydro-2,2,4,4-teetramethyl-2H-1-benzothiopyran-6-yl)carbamoyl)benzoate","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","10543887",1999,"Heteroarotinoids inhibit head and neck cancer cell lines in vitro and in vivo through both RAR and RXR retinoic acid receptors.","10543887","methyl 4-((2,3-dihydro-2,2,4,4-teetramethyl-2H-1-benzothiopyran-6-yl)carbamoyl)benzoate","retinoic acid receptor alpha"]
["methyl 4-((2,3-dihydro-2,2,4,4-teetramethyl-2H-1-benzothiopyran-6-yl)carbamoyl)benzoate","retinoic acid receptor gamma_ag","retinoic acid receptor gamma","ag","10543887",1999,"Heteroarotinoids inhibit head and neck cancer cell lines in vitro and in vivo through both RAR and RXR retinoic acid receptors.","10543887","methyl 4-((2,3-dihydro-2,2,4,4-teetramethyl-2H-1-benzothiopyran-6-yl)carbamoyl)benzoate","retinoic acid receptor gamma"]
["methyl 4-((2,3-dihydro-2,2,4,4-teetramethyl-2H-1-benzothiopyran-6-yl)carbamoyl)benzoate","Retinoid X Receptors_ag","Retinoid X Receptors","ag","10543887",1999,"Heteroarotinoids inhibit head and neck cancer cell lines in vitro and in vivo through both RAR and RXR retinoic acid receptors.","10543887","methyl 4-((2,3-dihydro-2,2,4,4-teetramethyl-2H-1-benzothiopyran-6-yl)carbamoyl)benzoate","Retinoid X Receptors"]
["Methylcholanthrene","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","10728918",2000,"Differential activities of CYP1A isozymes in hepatic and intestinal microsomes of control and 3-methylcholanthrene-induced rats.","10728918","Methylcholanthrene","Cytochrome P-450 CYP1A1"]
["Methylcholanthrene","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","14709899",2004,"Cytochrome P450 1A1 (CYP1A1) inhibitor alpha-naphthoflavone interferes with UDP-glucuronosyltransferase (UGT) activity in intact but not in permeabilized hepatic microsomes from 3-methylcholanthrene-treated rats: possible involvement of UGT-P450 interactions.","14709899","Methylcholanthrene","Cytochrome P-450 CYP1A1"]
["methylmercuric chloride","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","23541843",2013,"Posttranslational mechanisms modulating the expression of the cytochrome P450 1A1 gene by methylmercury in HepG2 cells: a role of heme oxygenase-1.","23541843","methylmercuric chloride","Cytochrome P-450 CYP1A1"]
["Metronidazole","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","3374631",1988,"A comment on Dr. Mack's article.","3374631","Metronidazole","Aldehyde Oxidoreductases"]
["Metronidazole","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","88568",1979,"Metronidazole and the fetal alcohol syndrome.","88568","Metronidazole","Aldehyde Oxidoreductases"]
["Mexiletine","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","10510742",1999,"Preferential inhibition of CYP1A enzymes in hepatic microsomes by mexiletine.","10510742","Mexiletine","Cytochrome P-450 CYP1A1"]
["Mexiletine","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","8689940",1995,"Relative potency of mexiletine, lidocaine, and tocainide as inhibitors of rat liver CYP1A1 activity.","8689940","Mexiletine","Cytochrome P-450 CYP1A1"]
["Miconazole","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","3263862",1988,"Inhibition of human hepatic and placental xenobiotic monooxygenases by imidazole antimycotics.","3263862","Miconazole","Cytochrome P-450 CYP1A1"]
["Misoprostol","Secretin_antag","Secretin","antag","7769193",1995,"Acid secretion during indomethacin therapy. Effect of misoprostol.","7769193","Misoprostol","Secretin"]
["MM11453","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","11406543",2001,"Apoptosis induction in cancer cells by a novel analogue of 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalenecarboxylic acid lacking retinoid receptor transcriptional activation activity.","11406543","MM11453","Receptors, Retinoic Acid"]
["molybdate",{"$f":"C1091&\"_\"&D1091","v":"Cytochrome P-450 CYP1A1_antag"},"Cytochrome P-450 CYP1A1","antag","10617682",2000,"Role of heat shock protein 90 dissociation in mediating agonist-induced activation of the aryl hydrocarbon receptor.","10617682","molybdate","Cytochrome P-450 CYP1A1"]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  I1092,I1092)","v":"Molybdenum"},"Cytochrome P-450 CYP1A1_antag",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  J1092,J1092)","v":"Cytochrome P-450 CYP1A1"},"antag",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & H1092,H1092)","v":"10617682"},2000,"Role of heat shock protein 90 dissociation in mediating agonist-induced activation of the aryl hydrocarbon receptor.","10617682","Molybdenum","Cytochrome P-450 CYP1A1"]
["Morphine","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","14741437",2004,"RXR-induced TNF-alpha suppression is reversed by morphine in activated U937 cells.","14741437","Morphine","Receptors, Retinoic Acid"]
["Morphine","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","14741437",2004,"RXR-induced TNF-alpha suppression is reversed by morphine in activated U937 cells.","14741437","Morphine","Receptors, Retinoic Acid"]
["Morphine","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","14976126",2004,"Opioid-induced cardioprotection occurs via glycogen synthase kinase beta inhibition during reperfusion in intact rat hearts.","14976126","Morphine","Receptors, Retinoic Acid"]
["Morphine","Retinoid X Receptors_ag","Retinoid X Receptors","ag","14741437",2004,"RXR-induced TNF-alpha suppression is reversed by morphine in activated U937 cells.","14741437","Morphine","Retinoid X Receptors"]
["Morphine","Retinoid X Receptors_ag","Retinoid X Receptors","ag","15579281",2004,"Nuclear receptor activation and interaction with morphine.","15579281","Morphine","Retinoid X Receptors"]
["Morphine","Retinoid X Receptors_antag","Retinoid X Receptors","antag","14741437",2004,"RXR-induced TNF-alpha suppression is reversed by morphine in activated U937 cells.","14741437","Morphine","Retinoid X Receptors"]
["muconaldehyde","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","3103627",1987,"Inhibition of microsomal cytochrome c reductase activity by a series of alpha, beta-unsaturated aldehydes.","3103627","muconaldehyde","Cytochrome P-450 CYP1A1"]
["N-(2-heptyl)-propargylamine","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","11454735",2001,"Inhibition of rat liver microsomal CYP1A2 and CYP2B1 activity by N-(2-heptyl)-N-methyl-propargylamine and by N-(2-heptyl)-propargylamine.","11454735","N-(2-heptyl)-propargylamine","Cytochrome P-450 CYP1A1"]
["N,N'-bis(dichloroacetyl)-1,8-octamethylenediamine","Retinal Dehydrogenase_antag","Retinal Dehydrogenase","antag","20705791",2011,"Suppression of spermatogenesis by bisdichloroacetyldiamines is mediated by inhibition of testicular retinoic acid biosynthesis.","20705791","N,N'-bis(dichloroacetyl)-1,8-octamethylenediamine","Retinal Dehydrogenase"]
["N6022","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","21570838",2011,"Structure-activity relationships of pyrrole based S-nitrosoglutathione reductase inhibitors: pyrrole regioisomers and propionic acid replacement.","21570838","N6022","Aldehyde Oxidoreductases"]
["N6022","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","21855338",2011,"Discovery of potent and novel S-nitrosoglutathione reductase inhibitors devoid of cytochrome P450 activities.","21855338","N6022","Aldehyde Oxidoreductases"]
["N6022","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","22210450",2012,"A nonclinical safety and pharmacokinetic evaluation of N6022: a first-in-class S-nitrosoglutathione reductase inhibitor for the treatment of asthma.","22210450","N6022","Aldehyde Oxidoreductases"]
["N6022","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","22335564",2012,"Mechanism of inhibition for N6022, a first-in-class drug targeting S-nitrosoglutathione reductase.","22335564","N6022","Aldehyde Oxidoreductases"]
["N6022","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","22342142",2012,"Structure-activity relationship of pyrrole based S-nitrosoglutathione reductase inhibitors: carboxamide modification.","22342142","N6022","Aldehyde Oxidoreductases"]
["N6022","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","24405692",2014,"Pharmacologic inhibition of S-nitrosoglutathione reductase protects against experimental asthma in BALB/c mice through attenuation of both bronchoconstriction and inflammation.","24405692","N6022","Aldehyde Oxidoreductases"]
["NAD","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","2297350",1990,"Nicotinamide adenine dinucleotide (NAD)-dependent oxidation of nicotine-delta 1'(5')-iminium ion to cotinine by rabbit liver microsomes.","2297350","NAD","Aldehyde Oxidoreductases"]
["NADP","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","40025",1979,"Nicotinamide adenine dinucleotide phosphate-decanaldehyde adduct as an inhibitor of beef brain NADP-linked aldehyde reductase.","40025","NADP","Aldehyde Oxidoreductases"]
["NADP","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","1386303",1992,"Elevated 4-hydroxylation of estradiol by hamster kidney microsomes: a potential pathway of metabolic activation of estrogens.","1386303","NADP","Cytochrome P-450 CYP1A1"]
["Nafronyl","retinyl esterase_antag","retinyl esterase","antag","12214558",2002,"Vitamin A metabolism is altered in brown Norway and long-Evans rats infused with naftidrofuryl or erythromycin intravenously.","12214558","Nafronyl","retinyl esterase"]
["narciclasine","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","21105682",2011,"Human cytochrome P450 liability studies of trans-dihydronarciclasine: a readily available, potent, and selective cancer cell growth inhibitor.","21105682","narciclasine","Cytochrome P-450 CYP1A1"]
["naringenin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","15460448",2004,"Suppression of CYP1A1 expression by naringenin in murine Hepa-1c1c7 cells.","15460448","naringenin","Cytochrome P-450 CYP1A1"]
["N-benzyl-1-aminobenzotriazole","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","2276091",1990,"N-aralkylated derivatives of 1-aminobenzotriazole as isozyme-selective, mechanism-based inhibitors of guinea pig hepatic cytochrome P-450 dependent monooxygenase activity.","2276091","N-benzyl-1-aminobenzotriazole","Cytochrome P-450 CYP1A1"]
["N-benzyl-1-aminobenzotriazole","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","8246152",1993,"Mechanism-based inactivation of cytochrome P450 1A1 by N-aralkyl-1-aminobenzotriazoles in guinea pig kidney in vivo and in vitro: minimal effects on metabolism of arachidonic acid by renal P450-dependent monooxygenases.","8246152","N-benzyl-1-aminobenzotriazole","Cytochrome P-450 CYP1A1"]
["N-benzyl-1-aminobenzotriazole","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","8886610",1996,"Kinetics and selectivity of mechanism-based inhibition of guinea pig hepatic and pulmonary cytochrome P450 by N-benzyl-1-aminobenzotriazole and N-alpha-methylbenzyl-1-aminobenzotriazole.","8886610","N-benzyl-1-aminobenzotriazole","Cytochrome P-450 CYP1A1"]
["neoquassin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","19016402",2009,"Inhibition of CYP1A1 by Quassinoids found in Picrasma excelsa.","19016402","neoquassin","Cytochrome P-450 CYP1A1"]
["Niacin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","23781857",2014,"Interspecies comparison of hepatic metabolism of six newly synthesized retinoid X receptor agonistic compounds possessing a 6-[N-ethyl-N-(alkoxyisopropylphenyl)amino]nicotinic acid skeleton in rat and human liver microsomes.","23781857","Niacin","Retinoid X Receptors"]
["Nickel","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","2109635",1990,"Activation of the nickel-deficient carbon monoxide dehydrogenase from Rhodospirillum rubrum: kinetic characterization and reductant requirement.","2109635","Nickel","Aldehyde Oxidoreductases"]
["Nickel","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","2504285",1989,"Nickel-specific, slow-binding inhibition of carbon monoxide dehydrogenase from Rhodospirillum rubrum by cyanide.","2504285","Nickel","Aldehyde Oxidoreductases"]
["Niclosamide","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","23956140",2013,"CYP1A1 and Cnr nitroreductase bioactivated niclosamide in vitro.","23956140","Niclosamide","Cytochrome P-450 CYP1A1"]
["Nicotine","Retinoblastoma Protein_antag","Retinoblastoma Protein","antag","16862215",2006,"Nicotine induces cell proliferation by beta-arrestin-mediated activation of Src and Rb-Raf-1 pathways.","16862215","Nicotine","Retinoblastoma Protein"]
["Nicotine","Retinoblastoma Protein_antag","Retinoblastoma Protein","antag","24398389",2014,"Nicotine-mediated cell proliferation and tumor progression in smoking-related cancers.","24398389","Nicotine","Retinoblastoma Protein"]
["Nicotine","retinoic acid 4-hydroxylase_antag","retinoic acid 4-hydroxylase","antag","21371177",2011,"Nicotine-mediated suppression of the retinoic acid metabolizing enzyme CYP26A1 limits the oncogenic potential of breast cancer.","21371177","Nicotine","retinoic acid 4-hydroxylase"]
["Nicotine","Secretin_antag","Secretin","antag","5007478",1972,"Potentiation, by nicotine, of duodenal ulcers in the rat.","5007478","Nicotine","Secretin"]
["Nitric Oxide","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","8170947",1994,"Inhibition of cytochromes P4501A by nitric oxide.","8170947","Nitric Oxide","Cytochrome P-450 CYP1A1"]
["Nitric Oxide","Retinoid X Receptors_ag","Retinoid X Receptors","ag","19732722",2009,"Growth factor-antagonized rexinoid apoptosis involves permissive PPARgamma/RXR heterodimers to activate the intrinsic death pathway by NO.","19732722","Nitric Oxide","Retinoid X Receptors"]
["N-nitrosopiperidine","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","17582584",2008,"Protective effects of isothiocyanates alone or in combination with vitamin C towards N-nitrosodibutylamine or N-nitrosopiperidine-induced oxidative DNA damage in the single-cell gel electrophoresis (SCGE)/HepG2 assay.","17582584","N-nitrosopiperidine","Cytochrome P-450 CYP1A1"]
["Nocodazole","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","8190110",1994,"Short and long term effects of cytoskeleton-disrupting drugs on cytochrome P450 Cyp1a-1 induction in murine hepatoma 1c1c7 cells: suppression by the microtubule inhibitor nocodazole.","8190110","Nocodazole","Cytochrome P-450 CYP1A1"]
["noduliprevenone","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","18830975",2008,"Noduliprevenone: a novel heterodimeric chromanone with cancer chemopreventive potential.","18830975","noduliprevenone","Cytochrome P-450 CYP1A1"]
["nonylphenol","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","16919910",2006,"Effects of nonylphenol on juveniles and adults in the grey mullet, Liza aurata.","16919910","nonylphenol","Cytochrome P-450 CYP1A1"]
["NSC 674495","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","11016648",2000,"Role of Cyp1A1 in modulation of antitumor properties of the novel agent 2-(4-amino-3-methylphenyl)benzothiazole (DF 203, NSC 674495) in human breast cancer cells.","11016648","NSC 674495","Cytochrome P-450 CYP1A1"]
["nutlin 3","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","21644822",2011,"Synthetic protocol published for promising anticancer compound.","21644822","nutlin 3","Receptors, Retinoic Acid"]
["nutlin 3","retinoic acid receptor gamma_ag","retinoic acid receptor gamma","ag","21644822",2011,"Synthetic protocol published for promising anticancer compound.","21644822","nutlin 3","retinoic acid receptor gamma"]
["octa-2,4,6-trienoic acid","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","10815891",2000,"Initial clinical trial of a high-affinity retinoic acid receptor ligand (LGD1550).","10815891","octa-2,4,6-trienoic acid","Receptors, Retinoic Acid"]
["octa-2,4,6-trienoic acid","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","16951191",2006,"Agonist and antagonist of retinoic acid receptors cause similar changes in gene expression and induce senescence-like growth arrest in MCF-7 breast carcinoma cells.","16951191","octa-2,4,6-trienoic acid","Receptors, Retinoic Acid"]
["octa-2,4,6-trienoic acid","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","16951191",2006,"Agonist and antagonist of retinoic acid receptors cause similar changes in gene expression and induce senescence-like growth arrest in MCF-7 breast carcinoma cells.","16951191","octa-2,4,6-trienoic acid","Receptors, Retinoic Acid"]
["oleanane","Retinoid X Receptors_antag","Retinoid X Receptors","antag","17446857",2007,"Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer.","17446857","oleanane","Retinoid X Receptors"]
["Oleanolic Acid","Retinoid X Receptors_antag","Retinoid X Receptors","antag","17446857",2007,"Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer.","17446857","Oleanolic Acid","Retinoid X Receptors"]
["Oleic Acid","Retinoid X Receptors_ag","Retinoid X Receptors","ag","23800855",2013,"Differential regulation of ABCA1 and macrophage cholesterol efflux by elaidic and oleic acids.","23800855","Oleic Acid","Retinoid X Receptors"]
["Oleic Acid","Secretin_antag","Secretin","antag","1735364",1992,"Role of endogenous secretin and cholecystokinin in intraduodenal oleic acid-induced inhibition of gastric acid secretion in rats.","1735364","Oleic Acid","Secretin"]
["oltipraz","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","17935951",2007,"Pharmacokinetic interaction between oltipraz and omeprazole in rats: Competitive inhibition of metabolism of oltipraz by omeprazole via CYP1A1 and 3A2, and of omeprazole by oltipraz via CYP1A1/2, 2D1/2, and 3A1/2.","17935951","oltipraz","Cytochrome P-450 CYP1A1"]
["Omeprazole","CYP1A1 protein, human_antag","CYP1A1 protein, human","antag","24265133",2014,"Identification of amino acid residues in the ligand-binding domain of the aryl hydrocarbon receptor causing the species-specific response to omeprazole: possible determinants for binding putative endogenous ligands.","24265133","Omeprazole","CYP1A1 protein, human"]
["Omeprazole","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","17935951",2007,"Pharmacokinetic interaction between oltipraz and omeprazole in rats: Competitive inhibition of metabolism of oltipraz by omeprazole via CYP1A1 and 3A2, and of omeprazole by oltipraz via CYP1A1/2, 2D1/2, and 3A1/2.","17935951","Omeprazole","Cytochrome P-450 CYP1A1"]
["Omeprazole","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","24265133",2014,"Identification of amino acid residues in the ligand-binding domain of the aryl hydrocarbon receptor causing the species-specific response to omeprazole: possible determinants for binding putative endogenous ligands.","24265133","Omeprazole","Cytochrome P-450 CYP1A1"]
["Omeprazole","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","7766737",1995,"Review article: omeprazole and the cytochrome P450 system.","7766737","Omeprazole","Cytochrome P-450 CYP1A1"]
["Omeprazole","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","8412467",1993,"[Omeprazole and the cytochrome P450 system of the liver].","8412467","Omeprazole","Cytochrome P-450 CYP1A1"]
["Omeprazole","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","9784250",1998,"Induction of cytochrome P-450 1A1 by omeprazole in human HepG2 cells is protein tyrosine kinase-dependent and is not inhibited by alpha-naphthoflavone.","9784250","Omeprazole","Cytochrome P-450 CYP1A1"]
["ONO 3307","Secretin_antag","Secretin","antag","8460415",1993,"Protective effects of therapy with a protease and xanthine oxidase inhibitor in short form pancreatic biliary obstruction and ischemia in rats.","8460415","ONO 3307","Secretin"]
["osteum","Secretin_antag","Secretin","antag","2890695",1987,"Role of secretin and CCK in the stimulation of pancreatic secretion in conscious dogs. Effects of atropine and somatostatin.","2890695","osteum","Secretin"]
["Ouabain","Secretin_antag","Secretin","antag","3822758",1986,"Intraepithelial current flow in rat pancreatic secretory epithelia.","3822758","Ouabain","Secretin"]
["oxatomide","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","15133245",2004,"Identification of human p450 isoforms involved in the metabolism of the antiallergic drug, oxatomide, and its inhibitory effect on enzyme activity.","15133245","oxatomide","Cytochrome P-450 CYP1A1"]
["Oxygen","Retinoid X Receptors_antag","Retinoid X Receptors","antag","24286031",2013,"High yields of oligodendrocyte lineage cells from human embryonic stem cells at physiological oxygen tensions for evaluation of translational biology.","24286031","Oxygen","Retinoid X Receptors"]
["p-(2-(N-butylcarbazol-3'-yl)ethen-1-yl)benzoic acid","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","21506276",2011,"Design and stereoselective synthesis of retinoids with ferrocene or N-butylcarbazole pharmacophores that induce post-differentiation apoptosis in acute promyelocytic leukemia cells.","21506276","p-(2-(N-butylcarbazol-3'-yl)ethen-1-yl)benzoic acid","Receptors, Retinoic Acid"]
["p-(2-(N-butylcarbazol-3'-yl)ethen-1-yl)benzoic acid",{"$f":"C1155&\"_\"&D1155","v":"retinoic acid receptor alpha_ag"},"retinoic acid receptor alpha","ag","21506276",2011,"Design and stereoselective synthesis of retinoids with ferrocene or N-butylcarbazole pharmacophores that induce post-differentiation apoptosis in acute promyelocytic leukemia cells.","21506276","p-(2-(N-butylcarbazol-3'-yl)ethen-1-yl)benzoic acid","retinoic acid receptor alpha"]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  I1156,I1156)","v":"p-(4-ferrocenylbuta-1,3-dien-1-yl)benzoic acid"},"Receptors, Retinoic Acid_ag",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  J1156,J1156)","v":"Receptors, Retinoic Acid"},"ag",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & H1156,H1156)","v":"21506276"},2011,"Design and stereoselective synthesis of retinoids with ferrocene or N-butylcarbazole pharmacophores that induce post-differentiation apoptosis in acute promyelocytic leukemia cells.","21506276","p-(4-ferrocenylbuta-1,3-dien-1-yl)benzoic acid","Receptors, Retinoic Acid"]
["p-(4-ferrocenylbuta-1,3-dien-1-yl)benzoic acid","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","21506276",2011,"Design and stereoselective synthesis of retinoids with ferrocene or N-butylcarbazole pharmacophores that induce post-differentiation apoptosis in acute promyelocytic leukemia cells.","21506276","p-(4-ferrocenylbuta-1,3-dien-1-yl)benzoic acid","retinoic acid receptor alpha"]
["Paclitaxel","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","11751388",2001,"Synergistic cytotoxicity exhibited by combination treatment of selective retinoid ligands with taxol (Paclitaxel).","11751388","Paclitaxel","Receptors, Retinoic Acid"]
["Paclitaxel","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","11751388",2001,"Synergistic cytotoxicity exhibited by combination treatment of selective retinoid ligands with taxol (Paclitaxel).","11751388","Paclitaxel","retinoic acid receptor alpha"]
["Paclitaxel","retinoic acid receptor beta_ag","retinoic acid receptor beta","ag","11751388",2001,"Synergistic cytotoxicity exhibited by combination treatment of selective retinoid ligands with taxol (Paclitaxel).","11751388","Paclitaxel","retinoic acid receptor beta"]
["palmatine","CYP1A1 protein, human_antag","CYP1A1 protein, human","antag","23886934",2013,"Inhibition of CYP1 by berberine, palmatine, and jatrorrhizine: selectivity, kinetic characterization, and molecular modeling.","23886934","palmatine","CYP1A1 protein, human"]
["palmatine","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","23886934",2013,"Inhibition of CYP1 by berberine, palmatine, and jatrorrhizine: selectivity, kinetic characterization, and molecular modeling.","23886934","palmatine","Cytochrome P-450 CYP1A1"]
["Palovarotene","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","19876792",2009,"Palovarotene, a novel retinoic acid receptor gamma agonist for the treatment of emphysema.","19876792","Palovarotene","Receptors, Retinoic Acid"]
["Palovarotene","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","20926506",2010,"Retinoid treatment of Emphysema in Patients on the Alpha-1 International Registry. The REPAIR study: study design, methodology and quality control of study assessments.","20926506","Palovarotene","Receptors, Retinoic Acid"]
["Palovarotene","retinoic acid receptor gamma_ag","retinoic acid receptor gamma","ag","19876792",2009,"Palovarotene, a novel retinoic acid receptor gamma agonist for the treatment of emphysema.","19876792","Palovarotene","retinoic acid receptor gamma"]
["Palovarotene","retinoic acid receptor gamma_ag","retinoic acid receptor gamma","ag","20926506",2010,"Retinoid treatment of Emphysema in Patients on the Alpha-1 International Registry. The REPAIR study: study design, methodology and quality control of study assessments.","20926506","Palovarotene","retinoic acid receptor gamma"]
["p-Aminoazobenzene","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","23250514",2013,"Distinct expression patterns and roles of aldehyde dehydrogenases in normal oral mucosa keratinocytes: differential inhibitory effects of a pharmacological inhibitor and RNAi-mediated knockdown on cellular phenotype and epithelial morphology.","23250514","p-Aminoazobenzene","Aldehyde Oxidoreductases"]
["Pargyline","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","449612",1979,"Susceptibility of brain aldehyde metabolizing enzymes to pargyline, disulfiram and diethylmaleate in vivo in rats.","449612","Pargyline","Aldehyde Oxidoreductases"]
["Pargyline","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","458796",1979,"Propiolaldehyde, a pargyline metabolite that irreversibly inhibits aldehyde dehydrogenase. Isolation from a hepatic microsomal system.","458796","Pargyline","Aldehyde Oxidoreductases"]
["Pargyline","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","523771",1979,"Further characterization of the inhibition of aldehyde dehydrogenase activity by pargyline.","523771","Pargyline","Aldehyde Oxidoreductases"]
["Pargyline","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","560851",1977,"Preferential inhibition of the low Km aldehyde dehydrogenase activity by pargyline.","560851","Pargyline","Aldehyde Oxidoreductases"]
["Pargyline","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","6263219",1980,"Effects of pargyline and diethyldithiocarbamate in vivo treatment on aldehyde dehydrogenase activities of submitochondrial fractions.","6263219","Pargyline","Aldehyde Oxidoreductases"]
["Pargyline","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","11454735",2001,"Inhibition of rat liver microsomal CYP1A2 and CYP2B1 activity by N-(2-heptyl)-N-methyl-propargylamine and by N-(2-heptyl)-propargylamine.","11454735","Pargyline","Cytochrome P-450 CYP1A1"]
["Particulate Matter","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","17060372",2007,"Urban dust particulate matter alters PAH-induced carcinogenesis by inhibition of CYP1A1 and CYP1B1.","17060372","Particulate Matter","Cytochrome P-450 CYP1A1"]
["p-Dimethylaminoazobenzene","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","15606778",2004,"Brain succinic semialdehyde dehydrogenase. Reactions of sulfhydryl residues connected with catalytic activity.","15606778","p-Dimethylaminoazobenzene","Aldehyde Oxidoreductases"]
["Pentachlorophenol","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","8896715",1996,"Pentachlorophenol enhances 9-hydroxybenzo [a] pyrene-induced hepatic DNA adduct formation in vivo and inhibits microsomal epoxide hydrolase and glutathione S-transferase activities in vitro: likely inhibition of epoxide detoxication by pentachlorophenol.","8896715","Pentachlorophenol","Cytochrome P-450 CYP1A1"]
["Pentobarbital","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","515041",1979,"Disulfiram inhibition and pentobarbital induction of rat testicular aldehyde dehydrogenase.","515041","Pentobarbital","Aldehyde Oxidoreductases"]
["perfluorodecanoic acid","retinol-palmitate esterase_antag","retinol-palmitate esterase","antag","3271875",1986,"The effects of nonadecafluoro-n-decanoic acid on serum retinol and hepatic retinyl palmitate hydrolase activity in male Sprague-Dawley rats.","3271875","perfluorodecanoic acid","retinol-palmitate esterase"]
["perfosfamide","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","6732847",1984,"Deoxyribonucleic acid crosslinking by 4-hydroperoxycyclophosphamide in cyclophosphamide-sensitive and -resistant L1210 cells.","6732847","perfosfamide","Aldehyde Oxidoreductases"]
["phenethyl isothiocyanate","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","17582584",2008,"Protective effects of isothiocyanates alone or in combination with vitamin C towards N-nitrosodibutylamine or N-nitrosopiperidine-induced oxidative DNA damage in the single-cell gel electrophoresis (SCGE)/HepG2 assay.","17582584","phenethyl isothiocyanate","Cytochrome P-450 CYP1A1"]
["Phenobarbital","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","10434373",1999,"Effects of aflatoxin B1 on the hepatic microsomal mixed function oxidase system during phenobarbital and benzo(a)pyrene treatment in chickens.","10434373","Phenobarbital","Cytochrome P-450 CYP1A1"]
["phentin acetate","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","10096365",1999,"Triphenyltin acetate-mediated in vitro inactivation of rat liver cytochrome P-450.","10096365","phentin acetate","Cytochrome P-450 CYP1A1"]
["phenylacetylene","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","8448348",1993,"Determinants of protein modification versus heme alkylation: inactivation of cytochrome P450 1A1 by 1-ethynylpyrene and phenylacetylene.","8448348","phenylacetylene","Cytochrome P-450 CYP1A1"]
["Phenylglyoxal","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","2819052",1989,"Chemical modification of the functional arginine residues of carbon monoxide dehydrogenase from Clostridium thermoaceticum.","2819052","Phenylglyoxal","Aldehyde Oxidoreductases"]
["Phytanic Acid","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","11690641",2001,"Phytanic acid and docosahexaenoic acid increase the metabolism of all-trans-retinoic acid and CYP26 gene expression in intestinal cells.","11690641","Phytanic Acid","Receptors, Retinoic Acid"]
["Phytanic Acid","Retinoid X Receptors_ag","Retinoid X Receptors","ag","11690641",2001,"Phytanic acid and docosahexaenoic acid increase the metabolism of all-trans-retinoic acid and CYP26 gene expression in intestinal cells.","11690641","Phytanic Acid","Retinoid X Receptors"]
["Phytol","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","12433198",2002,"Phytol, SSADH inhibitory diterpenoid of Lactuca sativa.","12433198","Phytol","Aldehyde Oxidoreductases"]
["Pilocarpine","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","7773543",1995,"The inhibition of CYP enzymes in mouse and human liver by pilocarpine.","7773543","Pilocarpine","Cytochrome P-450 CYP1A1"]
["pimaric acid","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","24799257",2014,"Retinoic acid receptor agonist activity of naturally occurring diterpenes.","24799257","pimaric acid","Receptors, Retinoic Acid"]
["pinostilbene","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","17440990",2007,"Inhibition of human recombinant cytochromes P450 CYP1A1 and CYP1B1 by trans-resveratrol methyl ethers.","17440990","pinostilbene","Cytochrome P-450 CYP1A1"]
["pioglitazone","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","22261616",2012,"Nuclear receptors agonists exert opposing effects on the inflammation dependent survival of breast cancer stem cells.","22261616","pioglitazone","Receptors, Retinoic Acid"]
["pioglitazone","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","11712405",2001,"[A trend of insulin sensitizer which is under development].","11712405","pioglitazone","Receptors, Retinoic Acid"]
["pioglitazone","Retinoid X Receptors_ag","Retinoid X Receptors","ag","22261616",2012,"Nuclear receptors agonists exert opposing effects on the inflammation dependent survival of breast cancer stem cells.","22261616","pioglitazone","Retinoid X Receptors"]
["pioglitazone","Retinoid X Receptors_antag","Retinoid X Receptors","antag","11712405",2001,"[A trend of insulin sensitizer which is under development].","11712405","pioglitazone","Retinoid X Receptors"]
["piperidine","Retinol-Binding Proteins, Plasma_antag","Retinol-Binding Proteins, Plasma","antag","25210858",2014,"Design, synthesis, and evaluation of nonretinoid retinol binding protein 4 antagonists for the potential treatment of atrophic age-related macular degeneration and Stargardt disease.","25210858","piperidine","Retinol-Binding Proteins, Plasma"]
["Pirenzepine","Secretin_antag","Secretin","antag","2443324",1987,"Inhibitory effects of pirenzepine on cholecystokinin and secretin stimulation on exocrine and endocrine rat pancreas.","2443324","Pirenzepine","Secretin"]
["Potassium Cyanide","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","2504285",1989,"Nickel-specific, slow-binding inhibition of carbon monoxide dehydrogenase from Rhodospirillum rubrum by cyanide.","2504285","Potassium Cyanide","Aldehyde Oxidoreductases"]
["Proadifen","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","8512597",1993,"Inhibition by SKF-525A of the aldehyde oxidase-mediated metabolism of the experimental antitumour agent acridine carboxamide.","8512597","Proadifen","Aldehyde Oxidoreductases"]
["prochloraz","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","2501938",1989,"Effects of the fungicide prochloraz on xenobiotic metabolism in rainbow trout: inhibition in vitro and time course of induction in vivo.","2501938","prochloraz","Cytochrome P-450 CYP1A1"]
["Progesterone","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","8095225",1993,"Caffeine, estradiol, and progesterone interact with human CYP1A1 and CYP1A2. Evidence from cDNA-directed expression in Saccharomyces cerevisiae.","8095225","Progesterone","Cytochrome P-450 CYP1A1"]
["Promazine","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","1417944",1992,"Inhibition and induction of cytochrome P450 2B1 in rat liver by promazine and chlorpromazine.","1417944","Promazine","Cytochrome P-450 CYP1A1"]
["Propane","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","18255114",2008,"Chemopreventive effects of Furan-2-yl-3-pyridin-2-yl-propenone against 7,12-dimethylbenz[a]anthracene-inducible genotoxicity.","18255114","Propane","Cytochrome P-450 CYP1A1"]
["Propane","Retinoid X Receptor alpha_ag","Retinoid X Receptor alpha","ag","18297677",2008,"The first potent subtype-selective retinoid X receptor (RXR) agonist possessing a 3-isopropoxy-4-isopropylphenylamino moiety, NEt-3IP (RXRalpha/beta-dual agonist).","18297677","Propane","Retinoid X Receptor alpha"]
["Propane","Retinoid X Receptor beta_ag","Retinoid X Receptor beta","ag","18297677",2008,"The first potent subtype-selective retinoid X receptor (RXR) agonist possessing a 3-isopropoxy-4-isopropylphenylamino moiety, NEt-3IP (RXRalpha/beta-dual agonist).","18297677","Propane","Retinoid X Receptor beta"]
["propargyl ether","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","23506553",2012,"Development of flavone propargyl ethers as potent and selective inhibitors of cytochrome P450 enzymes 1A1 and 1A2.","23506553","propargyl ether","Cytochrome P-450 CYP1A1"]
["propiolaldehyde","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","6377948",1984,"Inhibition of human aldehyde dehydrogenase isozymes by propiolaldehyde.","6377948","propiolaldehyde","Aldehyde Oxidoreductases"]
["propiolaldehyde","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","7392033",1980,"Metabolic depropargylation and its relationship to aldehyde dehydrogenase inhibition in vivo.","7392033","propiolaldehyde","Aldehyde Oxidoreductases"]
["propiolaldehyde","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","7424708",1980,"Microsomal N-depropargylation of pargyline to propiolaldehyde, an irreversible inhibitor of mitochondrial aldehyde dehydrogenase.","7424708","propiolaldehyde","Aldehyde Oxidoreductases"]
["propionic acid","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","21570838",2011,"Structure-activity relationships of pyrrole based S-nitrosoglutathione reductase inhibitors: pyrrole regioisomers and propionic acid replacement.","21570838","propionic acid","Aldehyde Oxidoreductases"]
["Propranolol","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","4145805",1973,"The inhibition of alcohol and aldehyde dehydrogenases by propranolol.","4145805","Propranolol","Aldehyde Oxidoreductases"]
["Propranolol","Secretin_antag","Secretin","antag","2103752",1990,"Effect of propranolol on secretin-induced gastrin release and secretin-induced tachycardia in patients with the Zollinger-Ellison syndrome.","2103752","Propranolol","Secretin"]
["Prostaglandin D2","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","11728177",2001,"Stimulated release of arachidonic acid by agonists of the peroxisome proliferator-activated receptor and retinoic acid receptors.","11728177","Prostaglandin D2","Receptors, Retinoic Acid"]
["Prostaglandin D2","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","14975592",2004,"Ligands for the peroxisome proliferator-activated receptor-gamma and the retinoid X receptor exert additive anti-inflammatory effects on experimental autoimmune encephalomyelitis.","14975592","Prostaglandin D2","Receptors, Retinoic Acid"]
["Prostaglandin D2","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","24098526",2013,"Amplified inhibition of stellate cell activation pathways by PPAR-γ, RAR and RXR agonists.","24098526","Prostaglandin D2","Receptors, Retinoic Acid"]
["Prostaglandin D2","Retinoid X Receptors_ag","Retinoid X Receptors","ag","14975592",2004,"Ligands for the peroxisome proliferator-activated receptor-gamma and the retinoid X receptor exert additive anti-inflammatory effects on experimental autoimmune encephalomyelitis.","14975592","Prostaglandin D2","Retinoid X Receptors"]
["Prostaglandin D2","Retinoid X Receptors_antag","Retinoid X Receptors","antag","24098526",2013,"Amplified inhibition of stellate cell activation pathways by PPAR-γ, RAR and RXR agonists.","24098526","Prostaglandin D2","Retinoid X Receptors"]
["Prostaglandins F, Synthetic","Retinoid X Receptor alpha_antag","Retinoid X Receptor alpha","antag","23989723",2013,"Latanoprost effectively ameliorates glucose and lipid disorders in db/db and ob/ob mice.","23989723","Prostaglandins F, Synthetic","Retinoid X Receptor alpha"]
["protocatechuic acid","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","12604171",2003,"Effect of naturally occurring plant phenolics on the induction of drug metabolizing enzymes by o-toluidine.","12604171","protocatechuic acid","Cytochrome P-450 CYP1A1"]
["pterostilbene",{"$f":"C1219&\"_\"&D1219","v":"Cytochrome P-450 CYP1A1_antag"},"Cytochrome P-450 CYP1A1","antag","17440990",2007,"Inhibition of human recombinant cytochromes P450 CYP1A1 and CYP1B1 by trans-resveratrol methyl ethers.","17440990","pterostilbene","Cytochrome P-450 CYP1A1"]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  I1220,I1220)","v":"punicalagin"},"Cytochrome P-450 CYP1A1_antag",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  J1220,J1220)","v":"Cytochrome P-450 CYP1A1"},"antag",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & H1220,H1220)","v":"19919114"},2009,"Effects of pomegranate chemical constituents/intestinal microbial metabolites on CYP1B1 in 22Rv1 prostate cancer cells.","19919114","punicalagin","Cytochrome P-450 CYP1A1"]
["punicalin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","19919114",2009,"Effects of pomegranate chemical constituents/intestinal microbial metabolites on CYP1B1 in 22Rv1 prostate cancer cells.","19919114","punicalin","Cytochrome P-450 CYP1A1"]
["Pyrogallol","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","1120498",1975,"Inhibition of liver aldehyde dehydrogenase by pyrogallol and related compounds.","1120498","Pyrogallol","Aldehyde Oxidoreductases"]
["Pyrogallol","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","196537",1976,"Studies on the effects of pyrogallol and the structurally related dopa decarboxylase inhibitor RO4-4602 on acetaldehyde metabolism.","196537","Pyrogallol","Aldehyde Oxidoreductases"]
["quassin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","19016402",2009,"Inhibition of CYP1A1 by Quassinoids found in Picrasma excelsa.","19016402","quassin","Cytochrome P-450 CYP1A1"]
["Quercetin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","11752233",2002,"Flavonoids inhibit genetic toxicity produced by carcinogens in cells expressing CYP1A2 and CYP1A1.","11752233","Quercetin","Cytochrome P-450 CYP1A1"]
["Quercetin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","12787821",2003,"Inhibition of clastogenicity of benzo[a]pyrene and of its trans-7,8-dihydrodiol in mice in vivo by fruits, vegetables, and flavonoids.","12787821","Quercetin","Cytochrome P-450 CYP1A1"]
["Quercetin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","22867086",2012,"Quercetin, resveratrol, and curcumin are indirect activators of the aryl hydrocarbon receptor (AHR).","22867086","Quercetin","Cytochrome P-450 CYP1A1"]
["Quercetin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","3925883",1985,"Inhibition of cytochrome P-450 activity in rat liver microsomes by the naturally occurring flavonoid, quercetin.","3925883","Quercetin","Cytochrome P-450 CYP1A1"]
["Quercetin","Retinal Dehydrogenase_antag","Retinal Dehydrogenase","antag","22422628",2013,"Quercetin in elimination of tumor initiating stem-like and mesenchymal transformation property in head and neck cancer.","22422628","Quercetin","Retinal Dehydrogenase"]
["Quinidine","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","11765139",2001,"Differential inhibition of human CYP1A1 and CYP1A2 by quinidine and quinine.","11765139","Quinidine","Cytochrome P-450 CYP1A1"]
["R 115866","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","23703360",2013,"Chemical activation of RARβ induces post-embryonically bilateral limb duplication during Xenopus limb regeneration.","23703360","R 115866","Receptors, Retinoic Acid"]
["R 115866","retinoic acid 4-hydroxylase_antag","retinoic acid 4-hydroxylase","antag","20580668",2010,"CYP26A1-specific antagonist influence on embryonic implantation, gene expression and endogenous retinoid concentration in rats.","20580668","R 115866","retinoic acid 4-hydroxylase"]
["R 115866","retinoic acid 4-hydroxylase_antag","retinoic acid 4-hydroxylase","antag","23703360",2013,"Chemical activation of RARβ induces post-embryonically bilateral limb duplication during Xenopus limb regeneration.","23703360","R 115866","retinoic acid 4-hydroxylase"]
["R116010","retinoic acid 4-hydroxylase_antag","retinoic acid 4-hydroxylase","antag","11870544",2002,"Inhibition of all-TRANS-retinoic acid metabolism by R116010 induces antitumour activity.","11870544","R116010","retinoic acid 4-hydroxylase"]
["R116010","retinoic acid 4-hydroxylase_antag","retinoic acid 4-hydroxylase","antag","17486130",2007,"Molecular targeting of retinoic acid metabolism in neuroblastoma: the role of the CYP26 inhibitor R116010 in vitro and in vivo.","17486130","R116010","retinoic acid 4-hydroxylase"]
["Raloxifene Hydrochloride","Retinoid X Receptors_ag","Retinoid X Receptors","ag","24080207",2013,"Chemopreventive efficacy of raloxifene, bexarotene, and their combination on the progression of chemically induced colon adenomas to adenocarcinomas in rats.","24080207","Raloxifene Hydrochloride","Retinoid X Receptors"]
["Reserpine","Secretin_antag","Secretin","antag","7514551",1994,"Alterations of the pancreatic secretory responses to secretin and to the ionophore A23187 by reserpine: a calcium-mediated phenomenon?","7514551","Reserpine","Secretin"]
["resveratrol","CYP1A1 protein, human_antag","CYP1A1 protein, human","antag","22863525",2012,"Design, synthesis and evaluation of the inhibitory selectivity of novel trans-resveratrol analogues on human recombinant CYP1A1, CYP1A2 and CYP1B1.","22863525","resveratrol","CYP1A1 protein, human"]
["resveratrol","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","10448061",1999,"Resveratrol is a selective human cytochrome P450 1A1 inhibitor.","10448061","resveratrol","Cytochrome P-450 CYP1A1"]
["resveratrol","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","10496959",1999,"Inhibition of aryl hydrocarbon-induced cytochrome P-450 1A1 enzyme activity and CYP1A1 expression by resveratrol.","10496959","resveratrol","Cytochrome P-450 CYP1A1"]
["resveratrol","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","11597580",2001,"Involvement of a post-transcriptional mechanism in the inhibition of CYP1A1 expression by resveratrol in breast cancer cells.","11597580","resveratrol","Cytochrome P-450 CYP1A1"]
["resveratrol","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","11701226",2001,"Inhibition of CYP3A, CYP1A and CYP2E1 activities by resveratrol and other non volatile red wine components.","11701226","resveratrol","Cytochrome P-450 CYP1A1"]
["resveratrol","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","11714871",2001,"Differential inhibition and inactivation of human CYP1 enzymes by trans-resveratrol: evidence for mechanism-based inactivation of CYP1A2.","11714871","resveratrol","Cytochrome P-450 CYP1A1"]
["resveratrol","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","15893423",2005,"CYP1A1 and CYP1B1 expressions in medulloblastoma cells are AhR-independent and have no direct link with resveratrol-induced differentiation and apoptosis.","15893423","resveratrol","Cytochrome P-450 CYP1A1"]
["resveratrol","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","17440990",2007,"Inhibition of human recombinant cytochromes P450 CYP1A1 and CYP1B1 by trans-resveratrol methyl ethers.","17440990","resveratrol","Cytochrome P-450 CYP1A1"]
["resveratrol","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","17560072",2007,"Developing a high-throughput system for the screening of cytochrome P450 1A1--inhibitory polyphenols.","17560072","resveratrol","Cytochrome P-450 CYP1A1"]
["resveratrol","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","18435436",2008,"Thiomethylstilbenes as inhibitors of CYP1A1, CYP1A2 and CYP1B1 activities.","18435436","resveratrol","Cytochrome P-450 CYP1A1"]
["resveratrol","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","19356012",2007,"In vitro inhibition of rat CYP1A1 and CYP1A2 by piceatannol, a hydroxylated metabolite of trans-resveratrol.","19356012","resveratrol","Cytochrome P-450 CYP1A1"]
["resveratrol","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","20716622",2010,"Estrogen receptor expression is required for low-dose resveratrol-mediated repression of aryl hydrocarbon receptor activity.","20716622","resveratrol","Cytochrome P-450 CYP1A1"]
["resveratrol","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","22863525",2012,"Design, synthesis and evaluation of the inhibitory selectivity of novel trans-resveratrol analogues on human recombinant CYP1A1, CYP1A2 and CYP1B1.","22863525","resveratrol","Cytochrome P-450 CYP1A1"]
["resveratrol","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","22867086",2012,"Quercetin, resveratrol, and curcumin are indirect activators of the aryl hydrocarbon receptor (AHR).","22867086","resveratrol","Cytochrome P-450 CYP1A1"]
["resveratrol","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","22534330",2012,"Resveratrol prevents impairment in activation of retinoic acid receptors and MAP kinases in the embryos of a rodent model of diabetic embryopathy.","22534330","resveratrol","Receptors, Retinoic Acid"]
["resveratrol","Retinoblastoma Protein_antag","Retinoblastoma Protein","antag","18567737",2008,"Resveratrol inhibits PDGF receptor mitogenic signaling in mesangial cells: role of PTP1B.","18567737","resveratrol","Retinoblastoma Protein"]
["retene","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","18511136",2008,"Evidence for multiple mechanisms of toxicity in larval rainbow trout (Oncorhynchus mykiss) co-treated with retene and alpha-naphthoflavone.","18511136","retene","Cytochrome P-450 CYP1A1"]
["Retinaldehyde","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","21851338",2011,"Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily.","21851338","Retinaldehyde","Receptors, Retinoic Acid"]
["retinol palmitate","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","10462515",1999,"Inhibitory effects of vitamin A and vitamin K on rat cytochrome P4501A1-dependent monooxygenase activity.","10462515","retinol palmitate","Cytochrome P-450 CYP1A1"]
["retinyl bromoacetate","lecithin-retinol acyltransferase_antag","lecithin-retinol acyltransferase","antag","8457568",1993,"Affinity labeling of lecithin retinol acyltransferase.","8457568","retinyl bromoacetate","lecithin-retinol acyltransferase"]
["retinyl retinoate","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","18511283",2008,"Synthesis and in vitro biological activity of retinyl retinoate, a novel hybrid retinoid derivative.","18511283","retinyl retinoate","Receptors, Retinoic Acid"]
["retinyl retinoate","retinoic acid binding protein II, cellular_ag","retinoic acid binding protein II, cellular","ag","18511283",2008,"Synthesis and in vitro biological activity of retinyl retinoate, a novel hybrid retinoid derivative.","18511283","retinyl retinoate","retinoic acid binding protein II, cellular"]
["retinylamine","retinoid isomerohydrolase_antag","retinoid isomerohydrolase","antag","18195010",2008,"Metabolic basis of visual cycle inhibition by retinoid and nonretinoid compounds in the vertebrate retina.","18195010","retinylamine","retinoid isomerohydrolase"]
["rhapontigenin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","11259321",2001,"Mechanism-based inhibition of human cytochrome P450 1A1 by rhapontigenin.","11259321","rhapontigenin","Cytochrome P-450 CYP1A1"]
["RNA, Messenger","Retinoblastoma Protein_antag","Retinoblastoma Protein","antag","7621252",1995,"Suppression of tumorigenesis by transcription units expressing the antisense E6 and E7 messenger RNA (mRNA) for the transforming proteins of the human papilloma virus and the sense mRNA for the retinoblastoma gene in cervical carcinoma cells.","7621252","RNA, Messenger","Retinoblastoma Protein"]
["RNA, Small Interfering","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","18161011",2008,"Can CYP1A1 siRNA be an effective treatment for lung cancer?","18161011","RNA, Small Interfering","Cytochrome P-450 CYP1A1"]
["RNA, Small Interfering","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","22248814",2011,"Pooled shRNA screen for sensitizers to inhibition of the mitotic regulator polo-like kinase (PLK1).","22248814","RNA, Small Interfering","Receptors, Retinoic Acid"]
["RNA, Small Interfering","Retinoblastoma Protein_antag","Retinoblastoma Protein","antag","16798224",2006,"Inhibition of retinoblastoma tumor suppressor activity by RNA interference in lung cancer lines.","16798224","RNA, Small Interfering","Retinoblastoma Protein"]
["RNA, Small Interfering","Retinoblastoma Protein_antag","Retinoblastoma Protein","antag","18593909",2008,"Rb depletion results in deregulation of E-cadherin and induction of cellular phenotypic changes that are characteristic of the epithelial-to-mesenchymal transition.","18593909","RNA, Small Interfering","Retinoblastoma Protein"]
["RNA, Small Interfering","retinoic acid receptor alpha_antag","retinoic acid receptor alpha","antag","22248814",2011,"Pooled shRNA screen for sensitizers to inhibition of the mitotic regulator polo-like kinase (PLK1).","22248814","RNA, Small Interfering","retinoic acid receptor alpha"]
["RNA, Viral","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","23633948",2013,"Systems analysis of a RIG-I agonist inducing broad spectrum inhibition of virus infectivity.","23633948","RNA, Viral","Receptors, Retinoic Acid"]
["Ro 41-5253","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","17290005",2007,"A widely used retinoic acid receptor antagonist induces peroxisome proliferator-activated receptor-gamma activity.","17290005","Ro 41-5253","Receptors, Retinoic Acid"]
["Ro 41-5253","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","12042033",2002,"Overexpression of mucin genes induced by interleukin-1 beta, tumor necrosis factor-alpha, lipopolysaccharide, and neutrophil elastase is inhibited by a retinoic acid receptor alpha antagonist.","12042033","Ro 41-5253","Receptors, Retinoic Acid"]
["Ro 41-5253","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","15694661",2005,"Retinoids and human breast cancer: in vivo effects of an antagonist for RAR-alpha.","15694661","Ro 41-5253","Receptors, Retinoic Acid"]
["Ro 41-5253","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","17290005",2007,"A widely used retinoic acid receptor antagonist induces peroxisome proliferator-activated receptor-gamma activity.","17290005","Ro 41-5253","Receptors, Retinoic Acid"]
["Ro 41-5253","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","19747919",2009,"Retinoic acid receptor antagonists inhibit miR-10a expression and block metastatic behavior of pancreatic cancer.","19747919","Ro 41-5253","Receptors, Retinoic Acid"]
["Ro 41-5253","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","23102850",2013,"Retinoic acid signaling biomarkers after treatment with retinoic acid and retinoic acid receptor alpha antagonist (Ro 41-5253) in canine testis: an in vitro organ culture study.","23102850","Ro 41-5253","Receptors, Retinoic Acid"]
["Ro 41-5253","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","8284797",1994,"A retinoic acid receptor alpha antagonist counteracts retinoid teratogenicity in vitro and reduced incidence and/or severity of malformations in vivo.","8284797","Ro 41-5253","Receptors, Retinoic Acid"]
["Ro 41-5253","retinoic acid binding protein II, cellular_antag","retinoic acid binding protein II, cellular","antag","23102850",2013,"Retinoic acid signaling biomarkers after treatment with retinoic acid and retinoic acid receptor alpha antagonist (Ro 41-5253) in canine testis: an in vitro organ culture study.","23102850","Ro 41-5253","retinoic acid binding protein II, cellular"]
["Ro 41-5253","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","17290005",2007,"A widely used retinoic acid receptor antagonist induces peroxisome proliferator-activated receptor-gamma activity.","17290005","Ro 41-5253","retinoic acid receptor alpha"]
["Ro 41-5253","retinoic acid receptor alpha_antag","retinoic acid receptor alpha","antag","12042033",2002,"Overexpression of mucin genes induced by interleukin-1 beta, tumor necrosis factor-alpha, lipopolysaccharide, and neutrophil elastase is inhibited by a retinoic acid receptor alpha antagonist.","12042033","Ro 41-5253","retinoic acid receptor alpha"]
["Ro 41-5253","retinoic acid receptor alpha_antag","retinoic acid receptor alpha","antag","15694661",2005,"Retinoids and human breast cancer: in vivo effects of an antagonist for RAR-alpha.","15694661","Ro 41-5253","retinoic acid receptor alpha"]
["Ro 41-5253","retinoic acid receptor alpha_antag","retinoic acid receptor alpha","antag","17290005",2007,"A widely used retinoic acid receptor antagonist induces peroxisome proliferator-activated receptor-gamma activity.","17290005","Ro 41-5253","retinoic acid receptor alpha"]
["Ro 41-5253","retinoic acid receptor alpha_antag","retinoic acid receptor alpha","antag","23102850",2013,"Retinoic acid signaling biomarkers after treatment with retinoic acid and retinoic acid receptor alpha antagonist (Ro 41-5253) in canine testis: an in vitro organ culture study.","23102850","Ro 41-5253","retinoic acid receptor alpha"]
["Roflumilast","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","22258322",2012,"Roflumilast enhances the renal protective effects of retinoids in an HIV-1 transgenic mouse model of rapidly progressive renal failure.","22258322","Roflumilast","Receptors, Retinoic Acid"]
["Roflumilast",{"$f":"C1283&\"_\"&D1283","v":"retinoic acid receptor alpha_ag"},"retinoic acid receptor alpha","ag","22258322",2012,"Roflumilast enhances the renal protective effects of retinoids in an HIV-1 transgenic mouse model of rapidly progressive renal failure.","22258322","Roflumilast","retinoic acid receptor alpha"]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  I1284,I1284)","v":"roscovitine"},"Retinoblastoma Protein_antag",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  J1284,J1284)","v":"Retinoblastoma Protein"},"antag",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & H1284,H1284)","v":"14729633"},2004,"The Cyclin-dependent kinase inhibitor CYC202 (R-roscovitine) inhibits retinoblastoma protein phosphorylation, causes loss of Cyclin D1, and activates the mitogen-activated protein kinase pathway.","14729633","roscovitine","Retinoblastoma Protein"]
["rosiglitazone","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","10076998",1999,"A novel method for analysis of nuclear receptor function at natural promoters: peroxisome proliferator-activated receptor gamma agonist actions on aP2 gene expression detected using branched DNA messenger RNA quantitation.","10076998","rosiglitazone","Receptors, Retinoic Acid"]
["rosiglitazone","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","10936484",2000,"Peroxisome proliferator-activated receptor and retinoid X receptor ligands inhibit monocyte chemotactic protein-1-directed migration of monocytes.","10936484","rosiglitazone","Receptors, Retinoic Acid"]
["rosiglitazone","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","10951538",2000,"Retinoid X receptor agonists have anti-obesity effects and improve insulin sensitivity in Zucker fa/fa rats.","10951538","rosiglitazone","Receptors, Retinoic Acid"]
["rosiglitazone","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","10996400",2000,"HIV protease inhibitors block adipogenesis and increase lipolysis in vitro.","10996400","rosiglitazone","Receptors, Retinoic Acid"]
["rosiglitazone","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","11145125",2000,"The effects of rexinoids and rosiglitazone on body weight and uncoupling protein isoform expression in the Zucker fa/fa rat.","11145125","rosiglitazone","Receptors, Retinoic Acid"]
["rosiglitazone","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","11259621",2001,"Differential effects of rexinoids and thiazolidinediones on metabolic gene expression in diabetic rodents.","11259621","rosiglitazone","Receptors, Retinoic Acid"]
["rosiglitazone","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","11283155",2001,"Attenuation of colon inflammation through activators of the retinoid X receptor (RXR)/peroxisome proliferator-activated receptor gamma (PPARgamma) heterodimer. A basis for new therapeutic strategies.","11283155","rosiglitazone","Receptors, Retinoic Acid"]
["rosiglitazone","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","11344094",2001,"Induction of CD36 by all-trans retinoic acid: retinoic acid receptor signaling in the pathogenesis of atherosclerosis.","11344094","rosiglitazone","Receptors, Retinoic Acid"]
["rosiglitazone","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","11581301",2001,"Inhibition of RXR and PPARgamma ameliorates diet-induced obesity and type 2 diabetes.","11581301","rosiglitazone","Receptors, Retinoic Acid"]
["rosiglitazone","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","11872672",2002,"Regional differences in the response of human pre-adipocytes to PPARgamma and RXRalpha agonists.","11872672","rosiglitazone","Receptors, Retinoic Acid"]
["rosiglitazone","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","12954061",2003,"Design, synthesis, and structure-activity relationship studies of novel 6,7-locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic acids.","12954061","rosiglitazone","Receptors, Retinoic Acid"]
["rosiglitazone","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","9121558",1997,"Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists.","9121558","rosiglitazone","Receptors, Retinoic Acid"]
["rosiglitazone","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","11581301",2001,"Inhibition of RXR and PPARgamma ameliorates diet-induced obesity and type 2 diabetes.","11581301","rosiglitazone","Receptors, Retinoic Acid"]
["rosiglitazone","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","12954061",2003,"Design, synthesis, and structure-activity relationship studies of novel 6,7-locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic acids.","12954061","rosiglitazone","Receptors, Retinoic Acid"]
["rosiglitazone","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","10936484",2000,"Peroxisome proliferator-activated receptor and retinoid X receptor ligands inhibit monocyte chemotactic protein-1-directed migration of monocytes.","10936484","rosiglitazone","retinoic acid receptor alpha"]
["rosiglitazone","Retinoid X Receptors_ag","Retinoid X Receptors","ag","10076998",1999,"A novel method for analysis of nuclear receptor function at natural promoters: peroxisome proliferator-activated receptor gamma agonist actions on aP2 gene expression detected using branched DNA messenger RNA quantitation.","10076998","rosiglitazone","Retinoid X Receptors"]
["rosiglitazone","Retinoid X Receptors_ag","Retinoid X Receptors","ag","10951538",2000,"Retinoid X receptor agonists have anti-obesity effects and improve insulin sensitivity in Zucker fa/fa rats.","10951538","rosiglitazone","Retinoid X Receptors"]
["rosiglitazone","Retinoid X Receptors_ag","Retinoid X Receptors","ag","10996400",2000,"HIV protease inhibitors block adipogenesis and increase lipolysis in vitro.","10996400","rosiglitazone","Retinoid X Receptors"]
["rosiglitazone","Retinoid X Receptors_ag","Retinoid X Receptors","ag","11145125",2000,"The effects of rexinoids and rosiglitazone on body weight and uncoupling protein isoform expression in the Zucker fa/fa rat.","11145125","rosiglitazone","Retinoid X Receptors"]
["rosiglitazone","Retinoid X Receptors_ag","Retinoid X Receptors","ag","11259621",2001,"Differential effects of rexinoids and thiazolidinediones on metabolic gene expression in diabetic rodents.","11259621","rosiglitazone","Retinoid X Receptors"]
["rosiglitazone","Retinoid X Receptors_ag","Retinoid X Receptors","ag","11283155",2001,"Attenuation of colon inflammation through activators of the retinoid X receptor (RXR)/peroxisome proliferator-activated receptor gamma (PPARgamma) heterodimer. A basis for new therapeutic strategies.","11283155","rosiglitazone","Retinoid X Receptors"]
["rosiglitazone","Retinoid X Receptors_ag","Retinoid X Receptors","ag","11581301",2001,"Inhibition of RXR and PPARgamma ameliorates diet-induced obesity and type 2 diabetes.","11581301","rosiglitazone","Retinoid X Receptors"]
["rosiglitazone","Retinoid X Receptors_ag","Retinoid X Receptors","ag","11872672",2002,"Regional differences in the response of human pre-adipocytes to PPARgamma and RXRalpha agonists.","11872672","rosiglitazone","Retinoid X Receptors"]
["rosiglitazone","Retinoid X Receptors_ag","Retinoid X Receptors","ag","12954061",2003,"Design, synthesis, and structure-activity relationship studies of novel 6,7-locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic acids.","12954061","rosiglitazone","Retinoid X Receptors"]
["rosiglitazone","Retinoid X Receptors_ag","Retinoid X Receptors","ag","16269450",2006,"Biological characterization of a heterodimer-selective retinoid X receptor modulator: potential benefits for the treatment of type 2 diabetes.","16269450","rosiglitazone","Retinoid X Receptors"]
["rosiglitazone","Retinoid X Receptors_ag","Retinoid X Receptors","ag","18594976",2009,"Additive inhibitory effect of experimentally induced hepatic cirrhosis by agonists of peroxisome proliferator activator receptor gamma and retinoic acid receptor.","18594976","rosiglitazone","Retinoid X Receptors"]
["rosiglitazone","Retinoid X Receptors_ag","Retinoid X Receptors","ag","19644018",2009,"Combined low doses of PPARgamma and RXR ligands trigger an intrinsic apoptotic pathway in human breast cancer cells.","19644018","rosiglitazone","Retinoid X Receptors"]
["rosiglitazone","Retinoid X Receptors_ag","Retinoid X Receptors","ag","9121558",1997,"Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists.","9121558","rosiglitazone","Retinoid X Receptors"]
["rosiglitazone","Retinoid X Receptors_antag","Retinoid X Receptors","antag","11581301",2001,"Inhibition of RXR and PPARgamma ameliorates diet-induced obesity and type 2 diabetes.","11581301","rosiglitazone","Retinoid X Receptors"]
["rosiglitazone","Retinoid X Receptors_antag","Retinoid X Receptors","antag","12954061",2003,"Design, synthesis, and structure-activity relationship studies of novel 6,7-locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic acids.","12954061","rosiglitazone","Retinoid X Receptors"]
["rosiglitazone","Retinoid X Receptors_antag","Retinoid X Receptors","antag","21654191",2011,"Bid as a potential target of apoptotic effects exerted by low doses of PPARγ and RXR ligands in breast cancer cells.","21654191","rosiglitazone","Retinoid X Receptors"]
["Roxithromycin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","2395109",1990,"Inhibition of rat liver estrogen 2/4-hydroxylase activity by troleandomycin: comparison with erythromycin and roxithromycin.","2395109","Roxithromycin","Cytochrome P-450 CYP1A1"]
["rutecarpine","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","11854157",2002,"The alkaloid rutaecarpine is a selective inhibitor of cytochrome P450 1A in mouse and human liver microsomes.","11854157","rutecarpine","Cytochrome P-450 CYP1A1"]
["rutecarpine","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","12852960",2003,"Effect of structural modification on the inhibitory selectivity of rutaecarpine derivatives on human CYP1A1, CYP1A2, and CYP1B1.","12852960","rutecarpine","Cytochrome P-450 CYP1A1"]
["rutecarpine","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","1330548",1992,"Certain tryptophan photoproducts are inhibitors of cytochrome P450-dependent mutagenicity.","1330548","rutecarpine","Cytochrome P-450 CYP1A1"]
["Safrole","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","3660849",1987,"Inhibition of cytochrome P-450c-mediated benzo[a]pyrene hydroxylase and ethoxyresorufin O-deethylase by dihydrosafrole.","3660849","Safrole","Cytochrome P-450 CYP1A1"]
["Safrole","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","9105404",1997,"Distinction of CYP1A1 and CYP1A2 activity by selective inhibition using fluvoxamine and isosafrole.","9105404","Safrole","Cytochrome P-450 CYP1A1"]
["Salvia extract","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","20158154",2009,"Inhibition of the initiation stage of carcinogenesis by Salvia disermas constituents.","20158154","Salvia extract","Cytochrome P-450 CYP1A1"]
["sanglifehrin A","Retinoblastoma Protein_antag","Retinoblastoma Protein","antag","11313401",2001,"Sanglifehrin A, a novel cyclophilin-binding immunosuppressant, inhibits IL-2-dependent T cell proliferation at the G1 phase of the cell cycle.","11313401","sanglifehrin A","Retinoblastoma Protein"]
["sanguinarine","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","15993743",2005,"Sanguinarine activates polycyclic aromatic hydrocarbon associated metabolic pathways in human oral keratinocytes and tissues.","15993743","sanguinarine","Cytochrome P-450 CYP1A1"]
["sanguinarine","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","16115718",2006,"Investigation of sanguinarine and chelerythrine effects on CYP1A1 expression and activity in human hepatoma cells.","16115718","sanguinarine","Cytochrome P-450 CYP1A1"]
["SB 203580","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","15659807",2004,"Blockade by SB203580 of Cyp1a1 induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin, and the possible mechanism: possible involvement of the p38 mitogen-activated protein kinase pathway in shuttling of Ah receptor overexpressed in COS-7 cells.","15659807","SB 203580","Cytochrome P-450 CYP1A1"]
["SB 210661","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","12547725",2003,"Retinal dehydrogenase-2 is inhibited by compounds that induce congenital diaphragmatic hernias in rodents.","12547725","SB 210661","Aldehyde Oxidoreductases"]
["SB 210661","Retinal Dehydrogenase_antag","Retinal Dehydrogenase","antag","12547725",2003,"Retinal dehydrogenase-2 is inhibited by compounds that induce congenital diaphragmatic hernias in rodents.","12547725","SB 210661","Retinal Dehydrogenase"]
["Serotonin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","10672865",2000,"RAR gamma agonists inhibit proliferation of vascular smooth muscle cells.","10672865","Serotonin","Receptors, Retinoic Acid"]
["Serotonin","retinoic acid receptor gamma_ag","retinoic acid receptor gamma","ag","10672865",2000,"RAR gamma agonists inhibit proliferation of vascular smooth muscle cells.","10672865","Serotonin","retinoic acid receptor gamma"]
["Sesame Oil","Retinoblastoma Protein_antag","Retinoblastoma Protein","antag","17640297",2007,"Sesamin, a lignan of sesame, down-regulates cyclin D1 protein expression in human tumor cells.","17640297","Sesame Oil","Retinoblastoma Protein"]
["sesamin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","23065221",2013,"In vitro inhibition of 7-ethoxyresorufin-O-deethylase (EROD) and p-nitrophenol hydroxylase (PNPH) activities by sesamin in hepatic microsomes from two fish species.","23065221","sesamin","Cytochrome P-450 CYP1A1"]
["sesamin","Retinoblastoma Protein_antag","Retinoblastoma Protein","antag","17640297",2007,"Sesamin, a lignan of sesame, down-regulates cyclin D1 protein expression in human tumor cells.","17640297","sesamin","Retinoblastoma Protein"]
["sesamodil","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","10647906",1999,"Isoform selective inhibition and inactivation of human cytochrome P450s by methylenedioxyphenyl compounds.","10647906","sesamodil","Cytochrome P-450 CYP1A1"]
["shikonin","Retinoblastoma Protein_ag","Retinoblastoma Protein","ag","24106286",2013,"Shikonin inhibits thyroid cancer cell growth and invasiveness through targeting major signaling pathways.","24106286","shikonin","Retinoblastoma Protein"]
["Silicon","Retinoid X Receptors_ag","Retinoid X Receptors","ag","19496083",2009,"Silicon analogues of the RXR-selective retinoid agonist SR11237 (BMS649): chemistry and biology.","19496083","Silicon","Retinoid X Receptors"]
["silybin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","16528449",2006,"Silybin and dehydrosilybin inhibit cytochrome P450 1A1 catalytic activity: a study in human keratinocytes and human hepatoma cells.","16528449","silybin","Cytochrome P-450 CYP1A1"]
["Silymarin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","16528449",2006,"Silybin and dehydrosilybin inhibit cytochrome P450 1A1 catalytic activity: a study in human keratinocytes and human hepatoma cells.","16528449","Silymarin","Cytochrome P-450 CYP1A1"]
["Sirolimus","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","19507250",2009,"Inhibition of mammalian target of rapamycin signaling potentiates the effects of all-trans retinoic acid to induce growth arrest and differentiation of human acute myelogenous leukemia cells.","19507250","Sirolimus","Receptors, Retinoic Acid"]
["Smoke","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","11159756",2001,"Aryl hydrocarbon receptor signaling plays a significant role in mediating benzo[a]pyrene- and cigarette smoke condensate-induced cytogenetic damage in vivo.","11159756","Smoke","Cytochrome P-450 CYP1A1"]
["sodium arsenate","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","16713074",2006,"Arsenic inhibits induction of cytochrome P450 1A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin in human hepatoma cells.","16713074","sodium arsenate","Cytochrome P-450 CYP1A1"]
["sodium arsenite","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","11979425",2002,"Acute sodium arsenite administration induces pulmonary CYP1A1 mRNA, protein and activity in the rat.","11979425","sodium arsenite","Cytochrome P-450 CYP1A1"]
["sodium arsenite","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","8431965",1993,"Effects of acute sodium arsenite administration on the pulmonary chemical metabolizing enzymes, cytochrome P-450 monooxygenase, NAD(P)H:quinone acceptor oxidoreductase and glutathione S-transferase in guinea pig: comparison with effects in liver and kidney.","8431965","sodium arsenite","Cytochrome P-450 CYP1A1"]
["Sodium Selenite","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","20508291",2010,"Selenitetriglicerydes affect CYP1A1 and QR activity by involvement of reactive oxygen species and Nrf2 transcription factor.","20508291","Sodium Selenite","Cytochrome P-450 CYP1A1"]
["sodium sulfide","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","15264843",2004,"Effect of sodium sulfide on Ni-containing carbon monoxide dehydrogenases.","15264843","sodium sulfide","Aldehyde Oxidoreductases"]
["Sorbic Acid","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","12482435",2003,"Retinoic acid receptor ligands based on the 6-cyclopropyl-2,4-hexadienoic acid.","12482435","Sorbic Acid","Receptors, Retinoic Acid"]
["Spermidine",{"$f":"C1347&\"_\"&D1347","v":"Aldehyde Oxidoreductases_antag"},"Aldehyde Oxidoreductases","antag","7371867",1980,"The effect of polyamines on the enzymes of the 4-aminobutyric acid metabolism in mouse brain in vitro.","7371867","Spermidine","Aldehyde Oxidoreductases"]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  I1348,I1348)","v":"Spermine"},"Aldehyde Oxidoreductases_antag",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  J1348,J1348)","v":"Aldehyde Oxidoreductases"},"antag",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & H1348,H1348)","v":"7371867"},1980,"The effect of polyamines on the enzymes of the 4-aminobutyric acid metabolism in mouse brain in vitro.","7371867","Spermine","Aldehyde Oxidoreductases"]
["Spironolactone","Retinoid X Receptor gamma_ag","Retinoid X Receptor gamma","ag","24190430",2013,"Modulation of NKG2D ligand expression and metastasis in tumors by spironolactone via RXRγ activation.","24190430","Spironolactone","Retinoid X Receptor gamma"]
["Spironolactone","Retinoid X Receptor gamma_antag","Retinoid X Receptor gamma","antag","24190430",2013,"Modulation of NKG2D ligand expression and metastasis in tumors by spironolactone via RXRγ activation.","24190430","Spironolactone","Retinoid X Receptor gamma"]
["SPL-334","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","26209236",2015,"Pharmacological In Vivo Inhibition of S-Nitrosoglutathione Reductase Attenuates Bleomycin-Induced Inflammation and Fibrosis.","26209236","SPL-334","Aldehyde Oxidoreductases"]
["SR 11234","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","9366527",1997,"Enhancement of Calu-1 human lung carcinoma cell growth in serum-free medium by retinoids: dependence on AP-1 activation, but not on retinoid response element activation.","9366527","SR 11234","Receptors, Retinoic Acid"]
["SR 11237","Retinoid X Receptors_ag","Retinoid X Receptors","ag","19496083",2009,"Silicon analogues of the RXR-selective retinoid agonist SR11237 (BMS649): chemistry and biology.","19496083","SR 11237","Retinoid X Receptors"]
["SR-0065","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","21381756",2011,"Identification of a novel non-retinoid pan inverse agonist of the retinoic acid receptors.","21381756","SR-0065","Receptors, Retinoic Acid"]
["SR-0065","Retinoid X Receptors_ag","Retinoid X Receptors","ag","21381756",2011,"Identification of a novel non-retinoid pan inverse agonist of the retinoic acid receptors.","21381756","SR-0065","Retinoid X Receptors"]
["SRM 1597","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","17187366",2007,"Competitive inhibition of carcinogen-activating CYP1A1 and CYP1B1 enzymes by a standardized complex mixture of PAH extracted from coal tar.","17187366","SRM 1597","Cytochrome P-450 CYP1A1"]
["S-sulindac","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","19276279",2009,"Novel dithiolethione-modified nonsteroidal anti-inflammatory drugs in human hepatoma HepG2 and colon LS180 cells.","19276279","S-sulindac","Cytochrome P-450 CYP1A1"]
["Staurosporine","Retinoblastoma Protein_antag","Retinoblastoma Protein","antag","17018634",2006,"The differential staurosporine-mediated G1 arrest in normal versus tumor cells is dependent on the retinoblastoma protein.","17018634","Staurosporine","Retinoblastoma Protein"]
["SU 11657","promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein_antag","promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein","antag","12515727",2003,"A model of APL with FLT3 mutation is responsive to retinoic acid and a receptor tyrosine kinase inhibitor, SU11657.","12515727","SU 11657","promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein"]
["Sulindac","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","19276279",2009,"Novel dithiolethione-modified nonsteroidal anti-inflammatory drugs in human hepatoma HepG2 and colon LS180 cells.","19276279","Sulindac","Cytochrome P-450 CYP1A1"]
["Sulindac","Retinoid X Receptor alpha_antag","Retinoid X Receptor alpha","antag","20541701",2010,"NSAID sulindac and its analog bind RXRalpha and inhibit RXRalpha-dependent AKT signaling.","20541701","Sulindac","Retinoid X Receptor alpha"]
["Sulindac","Retinoid X Receptor alpha_antag","Retinoid X Receptor alpha","antag","23434637",2013,"Synthesis and SAR study of modulators inhibiting tRXRα-dependent AKT activation.","23434637","Sulindac","Retinoid X Receptor alpha"]
["Sulindac","Retinoid X Receptor alpha_antag","Retinoid X Receptor alpha","antag","24704507",2014,"Sulindac-derived RXRα modulators inhibit cancer cell growth by binding to a novel site.","24704507","Sulindac","Retinoid X Receptor alpha"]
["Tacrine","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","15258105",2004,"Inhibition of murine cytochrome P4501A by tacrine: in vitro studies.","15258105","Tacrine","Cytochrome P-450 CYP1A1"]
["Tacrine","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","8737959",1996,"Influence of fluvoxamine on tacrine metabolism in vitro: potential implication for the hepatotoxicity in vivo.","8737959","Tacrine","Cytochrome P-450 CYP1A1"]
["tamibarotene","promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein_antag","promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein","antag","17929112",2007,"PML-RARalpha inhibitors (ATRA, tamibaroten, arsenic troxide) for acute promyelocytic leukemia.","17929112","tamibarotene","promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein"]
["tamibarotene","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","19790202",2009,"Synthesis and pharmacological characterization of Disila-AM80 (Disila-tamibarotene) and Disila-AM580, silicon analogues of the RARalpha-selective retinoid agonists AM80 (Tamibarotene) and AM580.","19790202","tamibarotene","Receptors, Retinoic Acid"]
["tamibarotene","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","20138974",2010,"Disturbance of rapid eye movement sleep in senescence-accelerated mouse prone/8 mice is improved by retinoic acid receptor agonist Am80 (Tamibarotene).","20138974","tamibarotene","Receptors, Retinoic Acid"]
["tamibarotene","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","20551971",2011,"A retinoic acid receptor agonist Am80 rescues neurons, attenuates inflammatory reactions, and improves behavioral recovery after intracerebral hemorrhage in mice.","20551971","tamibarotene","Receptors, Retinoic Acid"]
["tamibarotene","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","20861477",2011,"Oral administration of retinoic acid receptor-alpha/beta-specific ligand Am80 suppresses experimental autoimmune uveoretinitis.","20861477","tamibarotene","Receptors, Retinoic Acid"]
["tamibarotene","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","22863914",2012,"Tamibarotene: a candidate retinoid drug for Alzheimer's disease.","22863914","tamibarotene","Receptors, Retinoic Acid"]
["tamibarotene","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","23203767",2013,"Am80, a retinoic acid receptor agonist, ameliorates murine vasculitis through the suppression of neutrophil migration and activation.","23203767","tamibarotene","Receptors, Retinoic Acid"]
["tamibarotene","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","23404745",2013,"A retinoic acid receptor agonist tamibarotene suppresses iron accumulation in the liver.","23404745","tamibarotene","Receptors, Retinoic Acid"]
["tamibarotene","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","23624141",2013,"The retinoic acid receptor agonist Am80 increases hippocampal ADAM10 in aged SAMP8 mice.","23624141","tamibarotene","Receptors, Retinoic Acid"]
["tamibarotene","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","23992409",2013,"Synthetic retinoid Am80 up-regulates apelin expression by promoting interaction of RARα with KLF5 and Sp1 in vascular smooth muscle cells.","23992409","tamibarotene","Receptors, Retinoic Acid"]
["tamibarotene","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","24036839",2013,"The retinoic acid receptor agonist Am80 increases mucosal inflammation in an IL-6 dependent manner during Trichuris muris infection.","24036839","tamibarotene","Receptors, Retinoic Acid"]
["tamibarotene","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","24709559",2014,"The synthetic retinoid Am80 delays recovery in a model of multiple sclerosis by modulating myeloid-derived suppressor cell fate and viability.","24709559","tamibarotene","Receptors, Retinoic Acid"]
["tamibarotene","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","24916544",2014,"Cooperative therapeutic action of retinoic acid receptor and retinoid x receptor agonists in a mouse model of Alzheimer's disease.","24916544","tamibarotene","Receptors, Retinoic Acid"]
["tamibarotene","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","25448496",2014,"Tamibarotene modulates the local immune response in experimental periodontitis.","25448496","tamibarotene","Receptors, Retinoic Acid"]
["tamibarotene","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","19790202",2009,"Synthesis and pharmacological characterization of Disila-AM80 (Disila-tamibarotene) and Disila-AM580, silicon analogues of the RARalpha-selective retinoid agonists AM80 (Tamibarotene) and AM580.","19790202","tamibarotene","retinoic acid receptor alpha"]
["tamibarotene","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","20138974",2010,"Disturbance of rapid eye movement sleep in senescence-accelerated mouse prone/8 mice is improved by retinoic acid receptor agonist Am80 (Tamibarotene).","20138974","tamibarotene","retinoic acid receptor alpha"]
["tamibarotene","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","20861477",2011,"Oral administration of retinoic acid receptor-alpha/beta-specific ligand Am80 suppresses experimental autoimmune uveoretinitis.","20861477","tamibarotene","retinoic acid receptor alpha"]
["tamibarotene","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","23404745",2013,"A retinoic acid receptor agonist tamibarotene suppresses iron accumulation in the liver.","23404745","tamibarotene","retinoic acid receptor alpha"]
["tamibarotene","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","23992409",2013,"Synthetic retinoid Am80 up-regulates apelin expression by promoting interaction of RARα with KLF5 and Sp1 in vascular smooth muscle cells.","23992409","tamibarotene","retinoic acid receptor alpha"]
["tamibarotene","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","24709559",2014,"The synthetic retinoid Am80 delays recovery in a model of multiple sclerosis by modulating myeloid-derived suppressor cell fate and viability.","24709559","tamibarotene","retinoic acid receptor alpha"]
["tamibarotene","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","25448496",2014,"Tamibarotene modulates the local immune response in experimental periodontitis.","25448496","tamibarotene","retinoic acid receptor alpha"]
["tamibarotene","retinoic acid receptor beta_ag","retinoic acid receptor beta","ag","20861477",2011,"Oral administration of retinoic acid receptor-alpha/beta-specific ligand Am80 suppresses experimental autoimmune uveoretinitis.","20861477","tamibarotene","retinoic acid receptor beta"]
["tamibarotene","retinoic acid receptor beta_ag","retinoic acid receptor beta","ag","23404745",2013,"A retinoic acid receptor agonist tamibarotene suppresses iron accumulation in the liver.","23404745","tamibarotene","retinoic acid receptor beta"]
["tamibarotene","retinoic acid receptor beta_ag","retinoic acid receptor beta","ag","25448496",2014,"Tamibarotene modulates the local immune response in experimental periodontitis.","25448496","tamibarotene","retinoic acid receptor beta"]
["tamibarotene","Retinoid X Receptors_ag","Retinoid X Receptors","ag","24916544",2014,"Cooperative therapeutic action of retinoic acid receptor and retinoid x receptor agonists in a mouse model of Alzheimer's disease.","24916544","tamibarotene","Retinoid X Receptors"]
["Tamoxifen","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","17630414",2007,"Subchronic toxicity and toxicogenomic evaluation of tamoxifen citrate + bexarotene in female rats.","17630414","Tamoxifen","Receptors, Retinoic Acid"]
["Tamoxifen","Retinoblastoma Protein_antag","Retinoblastoma Protein","antag","11032025",2000,"Reversal of an antiestrogen-mediated cell cycle arrest of MCF-7 cells by viral tumor antigens requires the retinoblastoma protein-binding domain.","11032025","Tamoxifen","Retinoblastoma Protein"]
["Tamoxifen","Retinoblastoma Protein_antag","Retinoblastoma Protein","antag","21358261",2011,"A non-functional retinoblastoma tumor suppressor (RB) pathway in premenopausal breast cancer is associated with resistance to tamoxifen.","21358261","Tamoxifen","Retinoblastoma Protein"]
["Tamoxifen","Retinoblastoma Protein_antag","Retinoblastoma Protein","antag","21502809",2011,"RB pathway and therapeutic sensitivity: new insights in breast cancer and Tamoxifen therapy.","21502809","Tamoxifen","Retinoblastoma Protein"]
["tangeretin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","7483658",1995,"Effects of bioflavonoids on hepatic P450 activities.","7483658","tangeretin","Cytochrome P-450 CYP1A1"]
["tanshinone","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","12851037",2003,"Diterpene quinone tanshinone IIA selectively inhibits mouse and human cytochrome p4501A2.","12851037","tanshinone","Cytochrome P-450 CYP1A1"]
["tazarotene","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","9262312",1997,"Receptor specificity of retinoid-induced epidermal hyperplasia: effect of RXR-selective agonists and correlation with topical irritation.","9262312","tazarotene","Receptors, Retinoic Acid"]
["tazarotene","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","23925292",2013,"Retinoids activate the irritant receptor TRPV1 and produce sensory hypersensitivity.","23925292","tazarotene","Receptors, Retinoic Acid"]
["tazarotene","Retinoid X Receptors_ag","Retinoid X Receptors","ag","9262312",1997,"Receptor specificity of retinoid-induced epidermal hyperplasia: effect of RXR-selective agonists and correlation with topical irritation.","9262312","tazarotene","Retinoid X Receptors"]
["tebufelone","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","8723731",1996,"Characterization of the effects of tebufelone on hepatic cytochromes P450 in the beagle dog.","8723731","tebufelone","Cytochrome P-450 CYP1A1"]
["Tellurium","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","12482244",2002,"Comparative study on the bioactivation mechanisms and cytotoxicity of Te-phenyl-L-tellurocysteine, Se-phenyl-L-selenocysteine, and S-phenyl-L-cysteine.","12482244","Tellurium","Cytochrome P-450 CYP1A1"]
["TEMPO","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","10643866",2000,"The nitroxide stable radical tempo prevents metal-induced inhibition of CYP1A1 expression and induction.","10643866","TEMPO","Cytochrome P-450 CYP1A1"]
["tert-4-hydroxy-2-nonenal","Retinal Dehydrogenase_antag","Retinal Dehydrogenase","antag","22170038",2012,"Modulation of aldehyde dehydrogenase activity affects (±)-4-hydroxy-2E-nonenal (HNE) toxicity and HNE-protein adduct levels in PC12 cells.","22170038","tert-4-hydroxy-2-nonenal","Retinal Dehydrogenase"]
["Testosterone","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","10215637",1999,"Competition between cytochrome P-450 isozymes for NADPH-cytochrome P-450 oxidoreductase affects drug metabolism.","10215637","Testosterone","Cytochrome P-450 CYP1A1"]
["Tetrachlorodibenzodioxin","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","15664268",2005,"Identification of aldehyde oxidase 1 and aldehyde oxidase homologue 1 as dioxin-inducible genes.","15664268","Tetrachlorodibenzodioxin","Aldehyde Oxidoreductases"]
["Tetrachlorodibenzodioxin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","10799337",2000,"Diflubenzuron, a benzoyl-urea insecticide, is a potent inhibitor of TCDD-induced CYP1A1 expression in HepG2 cells.","10799337","Tetrachlorodibenzodioxin","Cytochrome P-450 CYP1A1"]
["Tetrachlorodibenzodioxin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","10862820",2000,"2,3,7,8-Tetrachlorodibenzo-p-dioxin alters melatonin metabolism in fish hepatocytes.","10862820","Tetrachlorodibenzodioxin","Cytochrome P-450 CYP1A1"]
["Tetrachlorodibenzodioxin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","11294972",2001,"2,3,7,8-Tetrachlorodibenzo-p-dioxin and diindolylmethanes differentially induce cytochrome P450 1A1, 1B1, and 19 in H295R human adrenocortical carcinoma cells.","11294972","Tetrachlorodibenzodioxin","Cytochrome P-450 CYP1A1"]
["Tetrachlorodibenzodioxin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","11358810",2001,"Differential regulation of cytochrome P450 1A1 and 1B1 by a combination of dioxin and pesticides in the breast tumor cell line MCF-7.","11358810","Tetrachlorodibenzodioxin","Cytochrome P-450 CYP1A1"]
["Tetrachlorodibenzodioxin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","12093619",2002,"Estradiol enhances and estriol inhibits the expression of CYP1A1 induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in a mouse ovarian cancer cell line.","12093619","Tetrachlorodibenzodioxin","Cytochrome P-450 CYP1A1"]
["Tetrachlorodibenzodioxin",{"$f":"C1411&\"_\"&D1411","v":"Cytochrome P-450 CYP1A1_antag"},"Cytochrome P-450 CYP1A1","antag","12215674",2002,"2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity in the zebrafish embryo: local circulation failure in the dorsal midbrain is associated with increased apoptosis.","12215674","Tetrachlorodibenzodioxin","Cytochrome P-450 CYP1A1"]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  I1412,I1412)","v":"Tetrachlorodibenzodioxin"},"Cytochrome P-450 CYP1A1_antag",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  J1412,J1412)","v":"Cytochrome P-450 CYP1A1"},"antag",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & H1412,H1412)","v":"15044633"},2004,"Regulation of NAD(P)H:quinone oxidoreductase 1 gene expression by CYP1A1 activity.","15044633","Tetrachlorodibenzodioxin","Cytochrome P-450 CYP1A1"]
["Tetrachlorodibenzodioxin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","15313166",2004,"Inhibition of the MEK-1/p42 MAP kinase reduces aryl hydrocarbon receptor-DNA interactions.","15313166","Tetrachlorodibenzodioxin","Cytochrome P-450 CYP1A1"]
["Tetrachlorodibenzodioxin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","15535986",2004,"Lack of antagonism of 2,3,7,8-tetrachlorodibenzo-p-dioxin's (TCDDs) induction of cytochrome P4501A1 (CYP1A1) by the putative selective aryl hydrocarbon receptor modulator 6-alkyl-1,3,8-trichlorodibenzofuran (6-MCDF) in the mouse hepatoma cell line Hepa-1c1c7.","15535986","Tetrachlorodibenzodioxin","Cytochrome P-450 CYP1A1"]
["Tetrachlorodibenzodioxin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","15630080",2005,"Arsenite inhibition of CYP1A1 induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin is independent of cell cycle arrest.","15630080","Tetrachlorodibenzodioxin","Cytochrome P-450 CYP1A1"]
["Tetrachlorodibenzodioxin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","15659807",2004,"Blockade by SB203580 of Cyp1a1 induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin, and the possible mechanism: possible involvement of the p38 mitogen-activated protein kinase pathway in shuttling of Ah receptor overexpressed in COS-7 cells.","15659807","Tetrachlorodibenzodioxin","Cytochrome P-450 CYP1A1"]
["Tetrachlorodibenzodioxin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","15728703",2005,"Inhibitory effects of vitamin A on TCDD-induced cytochrome P-450 1A1 enzyme activity and expression.","15728703","Tetrachlorodibenzodioxin","Cytochrome P-450 CYP1A1"]
["Tetrachlorodibenzodioxin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","16713074",2006,"Arsenic inhibits induction of cytochrome P450 1A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin in human hepatoma cells.","16713074","Tetrachlorodibenzodioxin","Cytochrome P-450 CYP1A1"]
["Tetrachlorodibenzodioxin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","17090139",2006,"TCDD-induced CYP1A1 expression, an index of dioxin toxicity, is suppressed by flavonoids permeating the human intestinal Caco-2 cell monolayers.","17090139","Tetrachlorodibenzodioxin","Cytochrome P-450 CYP1A1"]
["Tetrachlorodibenzodioxin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","18493746",2008,"Pharmacologic profiling of human and rat cytochrome P450 1A1 and 1A2 induction and competition.","18493746","Tetrachlorodibenzodioxin","Cytochrome P-450 CYP1A1"]
["Tetrachlorodibenzodioxin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","20550209",2010,"Metabolites of galangin by 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible cytochrome P450 1A1 in human intestinal epithelial Caco-2 cells and their antagonistic activity toward aryl hydrocarbon receptor.","20550209","Tetrachlorodibenzodioxin","Cytochrome P-450 CYP1A1"]
["Tetrachlorodibenzodioxin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","22044530",2011,"2,3,7,8-Tetrachlorodibenzo-p-dioxin's suppression of 1-nitropyrene-induced p53 expression is mediated by cytochrome P450 1A1.","22044530","Tetrachlorodibenzodioxin","Cytochrome P-450 CYP1A1"]
["Tetrachlorodibenzodioxin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","23566952",2013,"Sulforaphane inhibits CYP1A1 activity and promotes genotoxicity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in vitro.","23566952","Tetrachlorodibenzodioxin","Cytochrome P-450 CYP1A1"]
["Tetrachlorodibenzodioxin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","24397434",2014,"Complex interactions between dioxin-like and non-dioxin-like compounds for in vitro cellular responses: implications for the identification of dioxin exposure biomarkers.","24397434","Tetrachlorodibenzodioxin","Cytochrome P-450 CYP1A1"]
["Tetrachlorodibenzodioxin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","2593129",1989,"TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) is a tight binding inhibitor of cytochrome P-450d.","2593129","Tetrachlorodibenzodioxin","Cytochrome P-450 CYP1A1"]
["Tetrachlorodibenzodioxin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","7673247",1995,"Regulation of CYP1A1 by indolo[3,2-b]carbazole in murine hepatoma cells.","7673247","Tetrachlorodibenzodioxin","Cytochrome P-450 CYP1A1"]
["Tetradecanoylphorbol Acetate","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","2321243",1990,"Differential effects of 12-O-tetradecanoylphorbol 13-acetate on cytochrome P-450-dependent monooxygenase activities in rat hepatoma cells: induction of P-450I and suppression of P-450II.","2321243","Tetradecanoylphorbol Acetate","Cytochrome P-450 CYP1A1"]
["Tetradecanoylphorbol Acetate","Retinoid X Receptors_ag","Retinoid X Receptors","ag","19784811",2010,"Retinoid X receptor agonists inhibit phorbol-12-myristate-13-acetate (PMA)-induced differentiation of monocytic THP-1 cells into macrophages.","19784811","Tetradecanoylphorbol Acetate","Retinoid X Receptors"]
["Tetraethylammonium","Secretin_antag","Secretin","antag","3822758",1986,"Intraepithelial current flow in rat pancreatic secretory epithelia.","3822758","Tetraethylammonium","Secretin"]
["Thallium","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","1225625",1975,"Thallium activation and inhibition of yeast aldehyde dehydrogenase.","1225625","Thallium","Aldehyde Oxidoreductases"]
["Theophylline","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","11854157",2002,"The alkaloid rutaecarpine is a selective inhibitor of cytochrome P450 1A in mouse and human liver microsomes.","11854157","Theophylline","Cytochrome P-450 CYP1A1"]
["Theophylline","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","12495659",2003,"The presence of inducible cytochrome P450 types 1A1 and 1A2 in the BeWo cell line.","12495659","Theophylline","Cytochrome P-450 CYP1A1"]
["Theophylline","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","7975717",1994,"Characterization of the inhibition of P4501A2 by furafylline.","7975717","Theophylline","Cytochrome P-450 CYP1A1"]
["Thioridazine","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","2604739",1989,"In vitro inhibition of hepatic drug oxidation by thioridazine. Kinetic analysis of the inhibition of cytochrome P-450 isoform-specific reactions.","2604739","Thioridazine","Cytochrome P-450 CYP1A1"]
["Thiourea","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","16133793",2005,"Flexible heteroarotinoids (Flex-Hets) exhibit improved therapeutic ratios as anti-cancer agents over retinoic acid receptor agonists.","16133793","Thiourea","Receptors, Retinoic Acid"]
["Thiourea","Retinoid X Receptors_ag","Retinoid X Receptors","ag","16133793",2005,"Flexible heteroarotinoids (Flex-Hets) exhibit improved therapeutic ratios as anti-cancer agents over retinoic acid receptor agonists.","16133793","Thiourea","Retinoid X Receptors"]
["TO-901317","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","19887649",2010,"The benzenesulfoamide T0901317 [N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide] is a novel retinoic acid receptor-related orphan receptor-alpha/gamma inverse agonist.","19887649","TO-901317","Receptors, Retinoic Acid"]
["TO-901317","retinoic acid receptor gamma_ag","retinoic acid receptor gamma","ag","19887649",2010,"The benzenesulfoamide T0901317 [N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide] is a novel retinoic acid receptor-related orphan receptor-alpha/gamma inverse agonist.","19887649","TO-901317","retinoic acid receptor gamma"]
["TO-901317","Retinoid X Receptors_ag","Retinoid X Receptors","ag","16489205",2006,"PPARalpha activators and fasting induce the expression of adipose differentiation-related protein in liver.","16489205","TO-901317","Retinoid X Receptors"]
["Tocainide","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","8689940",1995,"Relative potency of mexiletine, lidocaine, and tocainide as inhibitors of rat liver CYP1A1 activity.","8689940","Tocainide","Cytochrome P-450 CYP1A1"]
["Toluene","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","8347164",1993,"Monoclonal antibody-directed assessment of toluene induction of rat hepatic cytochrome P450 isozymes.","8347164","Toluene","Cytochrome P-450 CYP1A1"]
["Toluene","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","9726784",1998,"Inhibition of rat lung mixed-function oxidase activity following repeated low-level toluene inhalation: possible role of toluene metabolites.","9726784","Toluene","Cytochrome P-450 CYP1A1"]
["trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","2411294",1985,"In vitro synthesis of vitamin D-3 by cultured human keratinocytes and fibroblasts: action spectrum and effect of AY-9944.","2411294","trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride","Aldehyde Oxidoreductases"]
["Tretinoin","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","10712624",2000,"Light-adaptive effects of retinoic acid on receptive field properties of retinal horizontal cells.","10712624","Tretinoin","Aldehyde Oxidoreductases"]
["Tretinoin","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","14738226",2004,"Retinoic acid induces alveolar regeneration in the adult mouse lung.","14738226","Tretinoin","Aldehyde Oxidoreductases"]
["Tretinoin","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","18028902",2007,"Wt1 and retinoic acid signaling are essential for stellate cell development and liver morphogenesis.","18028902","Tretinoin","Aldehyde Oxidoreductases"]
["Tretinoin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","16497785",2006,"Attenuation of oxygen-induced abnormal lung maturation in rats by retinoic acid: possible role of cytochrome P4501A enzymes.","16497785","Tretinoin","Cytochrome P-450 CYP1A1"]
["Tretinoin","N-homocysteine thiolactonyl retinamide_antag","N-homocysteine thiolactonyl retinamide","antag",15244035,2002,"Prevention of homocysteine thiolactone induced atherogenesis in rats.",15244035,"Tretinoin","N-homocysteine thiolactonyl retinamide"]
["Tretinoin","promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein_antag","promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein","antag","12008084",2002,"A metal chelator, diphenylthiocarbazone, induces apoptosis in acute promyelocytic leukemia (APL) cells mediated by a caspase-dependent pathway without a modulation of retinoic acid signaling pathways.","12008084","Tretinoin","promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein"]
["Tretinoin","promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein_antag","promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein","antag","12239173",2002,"Response to histone deacetylase inhibition of novel PML/RARalpha mutants detected in retinoic acid-resistant APL cells.","12239173","Tretinoin","promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein"]
["Tretinoin","promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein_antag","promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein","antag","12515727",2003,"A model of APL with FLT3 mutation is responsive to retinoic acid and a receptor tyrosine kinase inhibitor, SU11657.","12515727","Tretinoin","promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein"]
["Tretinoin","promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein_antag","promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein","antag","17468032",2007,"Acute promyelocytic leukemia: new issues on pathogenesis and treatment response.","17468032","Tretinoin","promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein"]
["Tretinoin","promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein_antag","promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein","antag","17929112",2007,"PML-RARalpha inhibitors (ATRA, tamibaroten, arsenic troxide) for acute promyelocytic leukemia.","17929112","Tretinoin","promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein"]
["Tretinoin","promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein_antag","promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein","antag","8874178",1996,"The PML/RAR alpha oncoprotein is a direct molecular target of retinoic acid in acute promyelocytic leukemia cells.","8874178","Tretinoin","promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","10585260",1999,"The expression and activity of D-type cyclins in F9 embryonal carcinoma cells: modulation of growth by RXR-selective retinoids.","10585260","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","10699977",2000,"Retinoic acid regulates the morphological development of sympathetic neurons.","10699977","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","11022230",2000,"Mechanisms of all-trans retinoic acid-induced differentiation of acute promyelocytic leukemia cells.","11022230","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","11084658",2000,"Role of retinoic acid in lens regeneration.","11084658","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","11201846",2000,"Thyroid hormone regulation of apoptosis induced by retinoic acid in promyeloleukemic HL-60 cells: studies with retinoic acid receptor-specific and retinoid x receptor-specific ligands.","11201846","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","11223164",2001,"Agonists of the retinoic acid- and retinoid X-receptors inhibit hepatocyte growth factor secretion and expression in U87 human astrocytoma cells.","11223164","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","11261782",2001,"Retinoic acid up-regulates myeloid ICAM-3 expression and function in a cell-specific fashion--evidence for retinoid signaling pathways in the mast cell lineage.","11261782","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","11319133",2001,"Retinoid receptors involved in the effects of retinoic acid on rat testis development.","11319133","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","11344094",2001,"Induction of CD36 by all-trans retinoic acid: retinoic acid receptor signaling in the pathogenesis of atherosclerosis.","11344094","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","11397803",2001,"Regulation of stearoyl coenzyme A desaturase expression in human retinal pigment epithelial cells by retinoic acid.","11397803","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","11483254",2001,"Retinoic acid receptors are expressed in human primary astrocytes and their agonists inhibit parathyroid hormone-related peptide expression and secretion.","11483254","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","11500296",2001,"Destabilization of TNF-alpha mRNA by retinoic acid in hepatic macrophages: implications for alcoholic liver disease.","11500296","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","11707111",2001,"Engineering orthogonal ligand-receptor pairs from \"near drugs\".","11707111","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","12006550",2002,"Nuclear receptor agonists as potential differentiation therapy agents for human osteosarcoma.","12006550","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","12169446",2002,"Enhancement of the inducible NO synthase activation by retinoic acid is mimicked by RARalpha agonist in vivo.","12169446","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","12421932",2002,"Retinoic acid stimulates the cell cycle machinery in normal T cells: involvement of retinoic acid receptor-mediated IL-2 secretion.","12421932","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","12882839",2003,"Retinoic acids exert direct effects on T cells to suppress Th1 development and enhance Th2 development via retinoic acid receptors.","12882839","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","12904083",2003,"Conformationally defined retinoic acid analogues. 5. Large-scale synthesis and mammary cancer chemopreventive activity for (2E,4E,6Z,8E)-8-(3',4'-dihydro-1'(2'H)-naphthalen-1'-ylidene)-3,7-dimethyl-2,4,6-octatrienoic acid (9cUAB30).","12904083","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","14613895",2004,"Retinoic acid inhibits rat XY gonad development by blocking mesonephric cell migration and decreasing the number of gonocytes.","14613895","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","14668795",2003,"Retinoic acid receptor alpha and retinoid-X receptor-specific agonists synergistically target telomerase expression and induce tumor cell death.","14668795","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin",{"$f":"C1475&\"_\"&D1475","v":"Receptors, Retinoic Acid_ag"},"Receptors, Retinoic Acid","ag","14975592",2004,"Ligands for the peroxisome proliferator-activated receptor-gamma and the retinoid X receptor exert additive anti-inflammatory effects on experimental autoimmune encephalomyelitis.","14975592","Tretinoin","Receptors, Retinoic Acid"]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  I1476,I1476)","v":"Tretinoin"},"Receptors, Retinoic Acid_ag",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  J1476,J1476)","v":"Receptors, Retinoic Acid"},"ag",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & H1476,H1476)","v":"14983400"},2004,"Retinoic acid increases insulin-like growth factor-binding protein-4 expression in cultured rat hepatocytes.","14983400","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","15161940",2004,"Non-genomic regulation of transmitter release by retinoic acid at developing motoneurons in Xenopus cell culture.","15161940","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","15546741",2004,"9-cis-retinoic acid analogues with bulky hydrophobic rings: new RXR-selective agonists.","15546741","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","15583048",2005,"Regulation of differentiating pig preadipocytes by retinoic acid.","15583048","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","15949693",2005,"Effects of retinoic acid administration and dietary vitamin A supplementation on leptin expression in mice: lack of correlation with changes of adipose tissue mass and food intake.","15949693","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","16038797",2005,"Phosphorylation of the retinoid x receptor at the omega loop, modulates the expression of retinoic-acid-target genes with a promoter context specificity.","16038797","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","16142401",2005,"All-trans retinoic acid regulates CXCL16/SR-PSOX expression.","16142401","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","16158052",2006,"Retinoic acid receptors and tissue-transglutaminase mediate short-term effect of retinoic acid on migration and invasion of neuroblastoma SH-SY5Y cells.","16158052","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","16302920",2005,"Retinoic acid is a potential negative regulator for differentiation of human periodontal ligament cells.","16302920","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","16309824",2005,"Retinoic acid amplifies the host immune response to LPS through increased T lymphocytes number and LPS binding protein expression.","16309824","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","16456186",2006,"Retinoic acid inhibits airway smooth muscle cell migration.","16456186","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","17204142",2007,"All-trans retinoic acid induces COX-2 and prostaglandin E2 synthesis in SH-SY5Y human neuroblastoma cells: involvement of retinoic acid receptors and extracellular-regulated kinase 1/2.","17204142","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","17307727",2007,"Chronically administered retinoic acid has trophic effects in the rat small intestine and promotes adaptation in a resection model of short bowel syndrome.","17307727","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","17595318",2007,"Rapid, nongenomic actions of retinoic acid on phosphatidylinositol-3-kinase signaling pathway mediated by the retinoic acid receptor.","17595318","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","18044685",2007,"Pulmonary stem cells and the induction of tissue regeneration in the treatment of emphysema.","18044685","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","18048326",2007,"Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha.","18048326","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","18466335",2008,"Effects of retinoic acids on the dendritic morphology of cultured hippocampal neurons.","18466335","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","18495924",2008,"Overcoming retinoic acid-resistance of mammary carcinomas by diverting retinoic acid from PPARbeta/delta to RAR.","18495924","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","18511283",2008,"Synthesis and in vitro biological activity of retinyl retinoate, a novel hybrid retinoid derivative.","18511283","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","18703560",2008,"Retinoic acid receptor gamma-induced misregulation of chondrogenesis in the murine limb bud in vitro.","18703560","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","18926686",2009,"Retinoic acid dampens LPS-induced NF-kappaB activity: results from human monoblasts and in vivo imaging of NF-kappaB reporter mice.","18926686","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","19068145",2008,"All-trans retinoic acid suppresses interleukin-6 expression in interleukin-1-stimulated synovial fibroblasts by inhibition of ERK1/2 pathway independently of RAR activation.","19068145","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","19450544",2009,"The ATRA-dependent overexpression of the glutamate transporter EAAC1 requires RARbeta induction.","19450544","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","19546303",2009,"Retinoids inhibit differentiation of hematopoietic osteoclast progenitors.","19546303","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","19770350",2009,"Activation of retinoic acid receptors by dihydroretinoids.","19770350","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","20557428",2010,"Inflammatory chemokine release of astrocytes in vitro is reduced by all-trans retinoic acid.","20557428","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","20562004",2010,"All-trans retinoic acid enhances the transport of phase II metabolites of benzo[a]pyrene by inducing the Breast Cancer Resistance Protein expression in Caco-2 cells.","20562004","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","20945395",2011,"Retinoic acid receptor-mediated signaling protects cardiomyocytes from hyperglycemia induced apoptosis: role of the renin-angiotensin system.","20945395","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","21099229",2011,"A role for all-trans-retinoic acid in the early steps of lymphatic vasculature development.","21099229","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","21145941",2011,"A novel retinoic acid analogue, 7-hydroxy retinoic acid, isolated from cyanobacteria.","21145941","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","21384111",2011,"Retinoic acid inhibits NFATc1 expression and osteoclast differentiation.","21384111","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","21628419",2011,"Retinoic acid isomers up-regulate ATP binding cassette A1 and G1 and cholesterol efflux in rat astrocytes: implications for their therapeutic and teratogenic effects.","21628419","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","22261616",2012,"Nuclear receptors agonists exert opposing effects on the inflammation dependent survival of breast cancer stem cells.","22261616","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","22353356",2012,"Retinoic acid receptor agonists regulate expression of ATP-binding cassette transporter G1 in macrophages.","22353356","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","22504942",2013,"Retinoids reduce formation of keratin aggregates in heat-stressed immortalized keratinocytes from an epidermolytic ichthyosis patient with a KRT10 mutation*.","22504942","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","23077743",2012,"Detection of retinoic acid receptor agonistic activity and identification of causative compounds in municipal wastewater treatment plants in Japan.","23077743","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","23228968",2013,"ATRA and the specific RARα agonist, NRX195183, have opposing effects on the clonogenicity of pre-leukemic murine AML1-ETO bone marrow cells.","23228968","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","23441952",2013,"Differential effects of retinoids and inhibitors of ERK and p38 signaling on adipogenic and myogenic differentiation of P19 stem cells.","23441952","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","23792233",2013,"Involvement of retinoic acid-induced peroxiredoxin 6 expression in recovery of noise-induced temporary hearing threshold shifts.","23792233","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","23992207",2013,"An in vitro model for the pro-fibrotic effects of retinoids: mechanisms of action.","23992207","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","24059847",2013,"Retinoic acid has different effects on UCP1 expression in mouse and human adipocytes.","24059847","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","24204796",2013,"All-trans retinoic acid modulates ORMDL3 expression via transcriptional regulation.","24204796","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","24994461",2014,"Retinoic acid acts as a selective human IgA switch factor.","24994461","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","25800721",2015,"RARγ is a negative regulator of osteoclastogenesis.","25800721","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","26205250",2015,"Selective Retinoic Acid Receptor γ Agonists Promote Repair of Injured Skeletal Muscle in Mouse.","26205250","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","26313912",2015,"Activation of RARα induces autophagy in SKBR3 breast cancer cells and depletion of key autophagy genes enhances ATRA toxicity.","26313912","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","7493627",1995,"Identification of a transposon-related RNA down-regulated by retinoic acid in embryonal carcinoma and embryonic stem cells.","7493627","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","7583541",1995,"Retinoids stimulate fibrinogen production both in vitro (hepatocytes) and in vivo. Induction requires activation of the retinoid X receptor.","7583541","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","7608895",1995,"Conformationally defined 6-s-trans-retinoic acid analogs. 2. Selective agonists for nuclear receptor binding and transcriptional activity.","7608895","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","7697779",1994,"Synthesis of 9E- and 9Z-locked retinoic acid analogs as ligands for RAR and RXR.","7697779","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","7934625",1994,"The prevention of adipose differentiation of 3T3-L1 cells caused by retinoic acid is elicited through retinoic acid receptor alpha.","7934625","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","8752277",1996,"Two distinct actions of retinoid-receptor ligands.","8752277","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","8788040",1996,"Receptor-selective retinoids implicate retinoic acid receptor alpha and gamma in the regulation of bmp-2 and bmp-4 in F9 embryonal carcinoma cells.","8788040","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","8892963",1996,"9-cis-retinoic acid induces neuronal differentiation of retinoic acid-nonresponsive embryonal carcinoma cells.","8892963","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","9077483",1997,"The retinoid X receptor agonist 9-cis-retinoic acid and the 24-hydroxylase inhibitor ketoconazole increase activity of 1,25-dihydroxyvitamin D3 in human skin in vivo.","9077483","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","9247151",1997,"9,13-di-cis-Retinoic acid induces the production of tPA and activation of latent TGF-beta via RAR alpha in a human liver stellate cell line, LI90.","9247151","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","9351827",1997,"Phosphorylation of activation functions AF-1 and AF-2 of RAR alpha and RAR gamma is indispensable for differentiation of F9 cells upon retinoic acid and cAMP treatment.","9351827","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","9392425",1997,"Mechanism of the slow induction of apolipoprotein A-I synthesis by retinoids in cynomolgus hepatocytes: involvement of retinoic acid and retinoid X receptors.","9392425","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","9436034",1997,"[Retinoic acid-induced cell growth inhibition and differentiation in testicular carcinoma cells in culture].","9436034","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","9573222",1998,"Ligand induction of retinoic acid receptors alters an acute infection by murine cytomegalovirus.","9573222","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","9816192",1996,"Initial clinical trial of the retinoid receptor pan agonist 9-cis retinoic acid.","9816192","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","9952315",1999,"Greater synergism of retinoic acid receptor (RAR) agonists with vitamin D3 than that of retinoid X receptor (RXR) agonists with regard to growth inhibition and differentiation induction in monoblastic leukemia cells.","9952315","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","10559885",1999,"Retinoic acid regulates programmed cell death through BMP signalling.","10559885","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin",{"$f":"C1539&\"_\"&D1539","v":"Receptors, Retinoic Acid_antag"},"Receptors, Retinoic Acid","antag","10627451",2000,"All-trans retinoic acid enhances the long-term repopulating activity of cultured hematopoietic stem cells.","10627451","Tretinoin","Receptors, Retinoic Acid"]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  I1540,I1540)","v":"Tretinoin"},"Receptors, Retinoic Acid_antag",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  J1540,J1540)","v":"Receptors, Retinoic Acid"},"antag",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & H1540,H1540)","v":"10652597"},1999,"Different effects of the treatment with AGN 193836 and 9-cis-retinoic acid in breast cancer cells.","10652597","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","10684250",2000,"Regulation of skeletal progenitor differentiation by the BMP and retinoid signaling pathways.","10684250","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","10725232",2000,"Retinoid signaling is essential for patterning the endoderm of the third and fourth pharyngeal arches.","10725232","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","11032179",2000,"Stage-dependent responses of the developing lung to retinoic acid signaling.","11032179","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","11084658",2000,"Role of retinoic acid in lens regeneration.","11084658","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","11212271",2001,"Granulocytic differentiation of human NB4 promyelocytic leukemia cells induced by all-trans retinoic acid metabolites.","11212271","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","11222649",2001,"Regulation of mouse kappa opioid receptor gene expression by retinoids.","11222649","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","11278809",2001,"Selective roles of retinoic acid receptor and retinoid x receptor in the suppression of apoptosis by all-trans-retinoic acid.","11278809","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","11319133",2001,"Retinoid receptors involved in the effects of retinoic acid on rat testis development.","11319133","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","11368771",2001,"Regulation by retinoic acid of acylation-stimulating protein and complement C3 in human adipocytes.","11368771","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","11487280",2001,"Antagonists of retinoic acid receptors (RARs) are potent growth inhibitors of prostate carcinoma cells.","11487280","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","11778229",2000,"[Mechanism of retinoic acid receptor alpha-mediated growth inhibition of gastric cancer cells by all-trans retinoic acid].","11778229","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","11857478",2002,"Retinoid antagonists inhibit normal patterning during limb regeneration in the axolotl, Ambystoma mexicanum.","11857478","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","11994980",2002,"all-trans-Retinoic acid-induced expression and regulation of retinoic acid 4-hydroxylase (CYP26) in human promyelocytic leukemia.","11994980","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","12139723",2002,"Superior effect of 9-cis retinoic acid (RA) compared with all-trans RA and 13-cis RA on the inhibition of clonogenic cell growth and the induction of apoptosis in OCI/AML-2 subclones: is the p53 pathway involved?","12139723","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","12421932",2002,"Retinoic acid stimulates the cell cycle machinery in normal T cells: involvement of retinoic acid receptor-mediated IL-2 secretion.","12421932","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","12807734",2003,"Molecular mechanism for growth suppression of human hepatocellular carcinoma cells by acyclic retinoid.","12807734","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","12877989",2003,"Ca2+-independent phospholipases A2 and production of arachidonic acid in nuclei of LA-N-1 cell cultures: a specific receptor activation mediated with retinoic acid.","12877989","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","12882839",2003,"Retinoic acids exert direct effects on T cells to suppress Th1 development and enhance Th2 development via retinoic acid receptors.","12882839","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","12935977",2003,"All-trans retinoic acid modulates microvascular endothelial cell hemostatic properties.","12935977","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","1323127",1992,"A retinoic acid receptor alpha antagonist selectively counteracts retinoic acid effects.","1323127","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","14613895",2004,"Retinoic acid inhibits rat XY gonad development by blocking mesonephric cell migration and decreasing the number of gonocytes.","14613895","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","14978018",2004,"Survival of activated human T lymphocytes is promoted by retinoic acid via induction of IL-2.","14978018","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","15583048",2005,"Regulation of differentiating pig preadipocytes by retinoic acid.","15583048","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","15674364",2005,"WEB-2086 and WEB-2170 trigger apoptosis in both ATRA-sensitive and -resistant promyelocytic leukemia cells and greatly enhance ATRA differentiation potential.","15674364","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","15703496",2005,"All-trans retinoic acid increases transgene expression in MSCV-transduced cells, via a mechanism that is retinoid receptor dependent but independent of cellular differentiation.","15703496","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","16142401",2005,"All-trans retinoic acid regulates CXCL16/SR-PSOX expression.","16142401","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","16158052",2006,"Retinoic acid receptors and tissue-transglutaminase mediate short-term effect of retinoic acid on migration and invasion of neuroblastoma SH-SY5Y cells.","16158052","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","16287870",2005,"Impaired retinoic acid (RA) signal leads to RARbeta2 epigenetic silencing and RA resistance.","16287870","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","16574820",2006,"Retinoid signaling determines germ cell fate in mice.","16574820","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","16872382",2006,"Effect of all-trans-retinoic acid on the differentiation, maturation and functions of dendritic cells derived from cord blood monocytes.","16872382","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","18466769",2008,"Acyclic retinoid inhibits functional interaction of transcription factors Krüppel-like factor 5 and retinoic acid receptor-alpha.","18466769","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","18641199",2008,"Retinoic acid decreases adherence of murine myeloid dendritic cells and increases production of matrix metalloproteinase-9.","18641199","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","18778286",2009,"Retinoic acid inhibits in vivo interleukin-2 gene expression and T-cell activation in mice.","18778286","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","18926686",2009,"Retinoic acid dampens LPS-induced NF-kappaB activity: results from human monoblasts and in vivo imaging of NF-kappaB reporter mice.","18926686","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","19279407",2009,"Mechanisms underlying the induction of the putative human tumor suppressor GPRC5A by retinoic acid.","19279407","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","19375825",2009,"Effect of conjugates of all-trans-retinoic acid and shorter polyene chain analogues with amino acids on prostate cancer cell growth.","19375825","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","19477911",2009,"All-trans retinoic acid down-regulates inflammatory responses by shifting the Treg/Th17 profile in human ulcerative and murine colitis.","19477911","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","19507250",2009,"Inhibition of mammalian target of rapamycin signaling potentiates the effects of all-trans retinoic acid to induce growth arrest and differentiation of human acute myelogenous leukemia cells.","19507250","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","20507312",2010,"All trans retinoic acid nanodisks enhance retinoic acid receptor mediated apoptosis and cell cycle arrest in mantle cell lymphoma.","20507312","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","20648638",2010,"Retinoic acid regulates myelin formation in the peripheral nervous system.","20648638","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","21384111",2011,"Retinoic acid inhibits NFATc1 expression and osteoclast differentiation.","21384111","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","21684744",2011,"A transcription factor hijacking to regulate RARα by using a chimeric molecule of retinoic acid and a DNA alkylator.","21684744","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","21728848",2011,"Chondrogenic effects of exogenous retinoic acid or a retinoic acid receptor antagonist (LE135) on equine chondrocytes and bone marrow-derived mesenchymal stem cells in monolayer culture.","21728848","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","21763841",2011,"Establishment of a rescue program for anorectal malformations induced by retinoic acid in mice.","21763841","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","22418437",2012,"Naturally occurring eccentric cleavage products of provitamin A β-carotene function as antagonists of retinoic acid receptors.","22418437","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","22659417",2012,"Epstein-Barr Virus latent membrane protein 1 overcomes all-trans retinoic acid-induced apoptosis by inhibiting retinoic acid receptor-β₂ expression.","22659417","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","22982089",2013,"Cellular retinoic acid binding protein I mediates rapid non-canonical activation of ERK1/2 by all-trans retinoic acid.","22982089","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","22982681",2012,"CAC1 negatively regulates RARα activity through cooperation with HDAC.","22982681","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","23102850",2013,"Retinoic acid signaling biomarkers after treatment with retinoic acid and retinoic acid receptor alpha antagonist (Ro 41-5253) in canine testis: an in vitro organ culture study.","23102850","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","23321499",2013,"Zyxin cooperates with PTOV1 to confer retinoic acid resistance by repressing RAR activity.","23321499","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","23441952",2013,"Differential effects of retinoids and inhibitors of ERK and p38 signaling on adipogenic and myogenic differentiation of P19 stem cells.","23441952","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","23485459",2013,"Molecular mechanism of 9-cis-retinoic acid inhibition of adipogenesis in 3T3-L1 cells.","23485459","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","23992207",2013,"An in vitro model for the pro-fibrotic effects of retinoids: mechanisms of action.","23992207","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","24059847",2013,"Retinoic acid has different effects on UCP1 expression in mouse and human adipocytes.","24059847","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","24098526",2013,"Amplified inhibition of stellate cell activation pathways by PPAR-γ, RAR and RXR agonists.","24098526","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","24495389",2014,"Effect of all-trans-retinoic acid on enterovirus 71 infection in vitro.","24495389","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","24608861",2014,"E2F1 impairs all-trans retinoic acid-induced osteogenic differentiation of osteosarcoma via promoting ubiquitination-mediated degradation of RARα.","24608861","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","24720764",2014,"Retinoic acid reduces migration of human breast cancer cells: role of retinoic acid receptor beta.","24720764","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","24788806",2014,"Retinoic acid and GM-CSF coordinately induce retinal dehydrogenase 2 (RALDH2) expression through cooperation between the RAR/RXR complex and Sp1 in dendritic cells.","24788806","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","24994461",2014,"Retinoic acid acts as a selective human IgA switch factor.","24994461","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","25090712",2014,"[Effect of retinociacdi combined extracts from testudinis carapacis et plastri on proliferating in MSCs and its mechanism].","25090712","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","25800721",2015,"RARγ is a negative regulator of osteoclastogenesis.","25800721","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin",{"$f":"C1603&\"_\"&D1603","v":"Receptors, Retinoic Acid_antag"},"Receptors, Retinoic Acid","antag","25899567",2015,"Modulation of dendritic cell alternative activation and function by the vitamin A metabolite retinoic acid.","25899567","Tretinoin","Receptors, Retinoic Acid"]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  I1604,I1604)","v":"Tretinoin"},"Receptors, Retinoic Acid_antag",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  J1604,J1604)","v":"Receptors, Retinoic Acid"},"antag",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & H1604,H1604)","v":"7575611"},1995,"Antagonism of COUP-TF and PPAR alpha/RXR alpha on the activation of the malic enzyme gene promoter: modulation by 9-cis RA.","7575611","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","7934625",1994,"The prevention of adipose differentiation of 3T3-L1 cells caused by retinoic acid is elicited through retinoic acid receptor alpha.","7934625","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","8274426",1993,"Mechanism of synergistic action of all-trans- or 9-cis-retinoic acid and interferons in breast cancer cells.","8274426","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","8387200",1993,"Retinoic acid is a negative regulator of the Epstein-Barr virus protein (BZLF1) that mediates disruption of latent infection.","8387200","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","8662962",1996,"Inhibition of retinoic acid receptor function and retinoic acid-regulated gene expression in mouse melanoma cells by calreticulin. A potential pathway for cyclic AMP regulation of retinoid action.","8662962","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","8695801",1996,"Stimulation of tissue-type plasminogen activator expression by retinoic acid in human endothelial cells requires retinoic acid receptor beta 2 induction.","8695801","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","8752277",1996,"Two distinct actions of retinoid-receptor ligands.","8752277","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","8788040",1996,"Receptor-selective retinoids implicate retinoic acid receptor alpha and gamma in the regulation of bmp-2 and bmp-4 in F9 embryonal carcinoma cells.","8788040","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","8937896",1996,"Retinoid-induced epiphyseal plate closure in guinea pigs.","8937896","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","9153223",1997,"All-trans-retinoic acid increases transforming growth factor-beta2 and insulin-like growth factor binding protein-3 expression through a retinoic acid receptor-alpha-dependent signaling pathway.","9153223","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","9160665",1997,"Involvement of retinoic acid receptor-alpha-mediated signaling pathway in induction of CD38 cell-surface antigen.","9160665","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","9165113",1997,"Retinoid signaling is required for the establishment of a ZPA and for the expression of Hoxb-8, a mediator of ZPA formation.","9165113","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","9247151",1997,"9,13-di-cis-Retinoic acid induces the production of tPA and activation of latent TGF-beta via RAR alpha in a human liver stellate cell line, LI90.","9247151","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","9342185",1997,"Retinoid-mediated inhibition of cell growth with stimulation of apoptosis in aggressive B-cell lymphomas.","9342185","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","9343411",1997,"Retinoid-induced chromatin structure alterations in the retinoic acid receptor beta2 promoter.","9343411","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","9366527",1997,"Enhancement of Calu-1 human lung carcinoma cell growth in serum-free medium by retinoids: dependence on AP-1 activation, but not on retinoid response element activation.","9366527","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","9516856",1997,"Retinoids in neuroblastoma therapy: distinct biological properties of 9-cis- and all-trans-retinoic acid.","9516856","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","9573222",1998,"Ligand induction of retinoic acid receptors alters an acute infection by murine cytomegalovirus.","9573222","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","9952315",1999,"Greater synergism of retinoic acid receptor (RAR) agonists with vitamin D3 than that of retinoid X receptor (RXR) agonists with regard to growth inhibition and differentiation induction in monoblastic leukemia cells.","9952315","Tretinoin","Receptors, Retinoic Acid"]
["Tretinoin","Retinal Dehydrogenase_antag","Retinal Dehydrogenase","antag","10712624",2000,"Light-adaptive effects of retinoic acid on receptive field properties of retinal horizontal cells.","10712624","Tretinoin","Retinal Dehydrogenase"]
["Tretinoin","Retinal Dehydrogenase_antag","Retinal Dehydrogenase","antag","14738226",2004,"Retinoic acid induces alveolar regeneration in the adult mouse lung.","14738226","Tretinoin","Retinal Dehydrogenase"]
["Tretinoin","Retinal Dehydrogenase_antag","Retinal Dehydrogenase","antag","22886539",2013,"Retinoic acid derived from the fetal ovary initiates meiosis in mouse germ cells.","22886539","Tretinoin","Retinal Dehydrogenase"]
["Tretinoin","Retinal Dehydrogenase_antag","Retinal Dehydrogenase","antag","25742746",2015,"All-trans retinoic acid downregulates ALDH1-mediated stemness and inhibits tumour formation in ovarian cancer cells.","25742746","Tretinoin","Retinal Dehydrogenase"]
["Tretinoin","Retinoblastoma Protein_antag","Retinoblastoma Protein","antag","9185997",1997,"All-trans-retinoic acid mediates G1 arrest but not apoptosis of normal human mammary epithelial cells.","9185997","Tretinoin","Retinoblastoma Protein"]
["Tretinoin","retinoic acid 4-hydroxylase_antag","retinoic acid 4-hydroxylase","antag","11870544",2002,"Inhibition of all-TRANS-retinoic acid metabolism by R116010 induces antitumour activity.","11870544","Tretinoin","retinoic acid 4-hydroxylase"]
["Tretinoin","retinoic acid 4-hydroxylase_antag","retinoic acid 4-hydroxylase","antag","12799139",2003,"Patterning of motor neurons by retinoic acid in the chick embryo hindbrain in vitro.","12799139","Tretinoin","retinoic acid 4-hydroxylase"]
["Tretinoin","retinoic acid 4-hydroxylase_antag","retinoic acid 4-hydroxylase","antag","16530416",2006,"Retinoic acid metabolism blocking agents (RAMBAs) for treatment of cancer and dermatological diseases.","16530416","Tretinoin","retinoic acid 4-hydroxylase"]
["Tretinoin","retinoic acid 4-hydroxylase_antag","retinoic acid 4-hydroxylase","antag","18722776",2008,"Novel azolyl-(phenylmethyl)]aryl/heteroarylamines: potent CYP26 inhibitors and enhancers of all-trans retinoic acid activity in neuroblastoma cells.","18722776","Tretinoin","retinoic acid 4-hydroxylase"]
["Tretinoin","retinoic acid 4-hydroxylase_antag","retinoic acid 4-hydroxylase","antag","19294396",2009,"Both all-trans retinoic acid and cytochrome P450 (CYP26) inhibitors affect the expression of vitamin A metabolizing enzymes and retinoid biomarkers in organotypic epidermis.","19294396","Tretinoin","retinoic acid 4-hydroxylase"]
["Tretinoin","retinoic acid 4-hydroxylase_antag","retinoic acid 4-hydroxylase","antag","20650878",2010,"Retinoic acid availability drives the asynchronous initiation of spermatogonial differentiation in the mouse.","20650878","Tretinoin","retinoic acid 4-hydroxylase"]
["Tretinoin","retinoic acid 4-hydroxylase_antag","retinoic acid 4-hydroxylase","antag","21249211",2011,"Cyp26b1 regulates retinoic acid-dependent signals in T cells and its expression is inhibited by transforming growth factor-β.","21249211","Tretinoin","retinoic acid 4-hydroxylase"]
["Tretinoin","retinoic acid 4-hydroxylase_antag","retinoic acid 4-hydroxylase","antag","23601821",2013,"2-(2-Methylfuran-3-carboxamido)-3-phenylpropanoic acid, a potential CYP26A1 inhibitor to enhance all-trans retinoic acid-induced leukemia cell differentiation based on virtual screening and biological evaluation.","23601821","Tretinoin","retinoic acid 4-hydroxylase"]
["Tretinoin","retinoic acid 4-hydroxylase_antag","retinoic acid 4-hydroxylase","antag","8757760",1996,"Liarozole inhibits human epidermal retinoic acid 4-hydroxylase activity and differentially augments human skin responses to retinoic acid and retinol in vivo.","8757760","Tretinoin","retinoic acid 4-hydroxylase"]
["Tretinoin","retinoic acid 4-hydroxylase_antag","retinoic acid 4-hydroxylase","antag","9716180",1998,"Human retinoic acid (RA) 4-hydroxylase (CYP26) is highly specific for all-trans-RA and can be induced through RA receptors in human breast and colon carcinoma cells.","9716180","Tretinoin","retinoic acid 4-hydroxylase"]
["Tretinoin","retinoic acid binding protein I, cellular_ag","retinoic acid binding protein I, cellular","ag","7608895",1995,"Conformationally defined 6-s-trans-retinoic acid analogs. 2. Selective agonists for nuclear receptor binding and transcriptional activity.","7608895","Tretinoin","retinoic acid binding protein I, cellular"]
["Tretinoin","retinoic acid binding protein I, cellular_antag","retinoic acid binding protein I, cellular","antag","22982089",2013,"Cellular retinoic acid binding protein I mediates rapid non-canonical activation of ERK1/2 by all-trans retinoic acid.","22982089","Tretinoin","retinoic acid binding protein I, cellular"]
["Tretinoin","retinoic acid binding protein II, cellular_ag","retinoic acid binding protein II, cellular","ag","16038797",2005,"Phosphorylation of the retinoid x receptor at the omega loop, modulates the expression of retinoic-acid-target genes with a promoter context specificity.","16038797","Tretinoin","retinoic acid binding protein II, cellular"]
["Tretinoin","retinoic acid binding protein II, cellular_ag","retinoic acid binding protein II, cellular","ag","18495924",2008,"Overcoming retinoic acid-resistance of mammary carcinomas by diverting retinoic acid from PPARbeta/delta to RAR.","18495924","Tretinoin","retinoic acid binding protein II, cellular"]
["Tretinoin","retinoic acid binding protein II, cellular_ag","retinoic acid binding protein II, cellular","ag","18511283",2008,"Synthesis and in vitro biological activity of retinyl retinoate, a novel hybrid retinoid derivative.","18511283","Tretinoin","retinoic acid binding protein II, cellular"]
["Tretinoin","retinoic acid binding protein II, cellular_ag","retinoic acid binding protein II, cellular","ag","19770350",2009,"Activation of retinoic acid receptors by dihydroretinoids.","19770350","Tretinoin","retinoic acid binding protein II, cellular"]
["Tretinoin","retinoic acid binding protein II, cellular_ag","retinoic acid binding protein II, cellular","ag","7608895",1995,"Conformationally defined 6-s-trans-retinoic acid analogs. 2. Selective agonists for nuclear receptor binding and transcriptional activity.","7608895","Tretinoin","retinoic acid binding protein II, cellular"]
["Tretinoin","retinoic acid binding protein II, cellular_antag","retinoic acid binding protein II, cellular","antag","23102850",2013,"Retinoic acid signaling biomarkers after treatment with retinoic acid and retinoic acid receptor alpha antagonist (Ro 41-5253) in canine testis: an in vitro organ culture study.","23102850","Tretinoin","retinoic acid binding protein II, cellular"]
["Tretinoin","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","11022230",2000,"Mechanisms of all-trans retinoic acid-induced differentiation of acute promyelocytic leukemia cells.","11022230","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","11397803",2001,"Regulation of stearoyl coenzyme A desaturase expression in human retinal pigment epithelial cells by retinoic acid.","11397803","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","12169446",2002,"Enhancement of the inducible NO synthase activation by retinoic acid is mimicked by RARalpha agonist in vivo.","12169446","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","14613895",2004,"Retinoic acid inhibits rat XY gonad development by blocking mesonephric cell migration and decreasing the number of gonocytes.","14613895","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","14668795",2003,"Retinoic acid receptor alpha and retinoid-X receptor-specific agonists synergistically target telomerase expression and induce tumor cell death.","14668795","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","15161940",2004,"Non-genomic regulation of transmitter release by retinoic acid at developing motoneurons in Xenopus cell culture.","15161940","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","15949693",2005,"Effects of retinoic acid administration and dietary vitamin A supplementation on leptin expression in mice: lack of correlation with changes of adipose tissue mass and food intake.","15949693","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","16038797",2005,"Phosphorylation of the retinoid x receptor at the omega loop, modulates the expression of retinoic-acid-target genes with a promoter context specificity.","16038797","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","16302920",2005,"Retinoic acid is a potential negative regulator for differentiation of human periodontal ligament cells.","16302920","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","16456186",2006,"Retinoic acid inhibits airway smooth muscle cell migration.","16456186","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","17595318",2007,"Rapid, nongenomic actions of retinoic acid on phosphatidylinositol-3-kinase signaling pathway mediated by the retinoic acid receptor.","17595318","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","18048326",2007,"Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha.","18048326","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","19450544",2009,"The ATRA-dependent overexpression of the glutamate transporter EAAC1 requires RARbeta induction.","19450544","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","20562004",2010,"All-trans retinoic acid enhances the transport of phase II metabolites of benzo[a]pyrene by inducing the Breast Cancer Resistance Protein expression in Caco-2 cells.","20562004","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","20945395",2011,"Retinoic acid receptor-mediated signaling protects cardiomyocytes from hyperglycemia induced apoptosis: role of the renin-angiotensin system.","20945395","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","21099229",2011,"A role for all-trans-retinoic acid in the early steps of lymphatic vasculature development.","21099229","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","23228968",2013,"ATRA and the specific RARα agonist, NRX195183, have opposing effects on the clonogenicity of pre-leukemic murine AML1-ETO bone marrow cells.","23228968","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","23792233",2013,"Involvement of retinoic acid-induced peroxiredoxin 6 expression in recovery of noise-induced temporary hearing threshold shifts.","23792233","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","24204796",2013,"All-trans retinoic acid modulates ORMDL3 expression via transcriptional regulation.","24204796","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","24994461",2014,"Retinoic acid acts as a selective human IgA switch factor.","24994461","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","25800721",2015,"RARγ is a negative regulator of osteoclastogenesis.","25800721","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin",{"$f":"C1667&\"_\"&D1667","v":"retinoic acid receptor alpha_ag"},"retinoic acid receptor alpha","ag","7934625",1994,"The prevention of adipose differentiation of 3T3-L1 cells caused by retinoic acid is elicited through retinoic acid receptor alpha.","7934625","Tretinoin","retinoic acid receptor alpha"]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  I1668,I1668)","v":"Tretinoin"},"retinoic acid receptor alpha_ag",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  J1668,J1668)","v":"retinoic acid receptor alpha"},"ag",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & H1668,H1668)","v":"8752277"},1996,"Two distinct actions of retinoid-receptor ligands.","8752277","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","8788040",1996,"Receptor-selective retinoids implicate retinoic acid receptor alpha and gamma in the regulation of bmp-2 and bmp-4 in F9 embryonal carcinoma cells.","8788040","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","9247151",1997,"9,13-di-cis-Retinoic acid induces the production of tPA and activation of latent TGF-beta via RAR alpha in a human liver stellate cell line, LI90.","9247151","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","9351827",1997,"Phosphorylation of activation functions AF-1 and AF-2 of RAR alpha and RAR gamma is indispensable for differentiation of F9 cells upon retinoic acid and cAMP treatment.","9351827","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","9436034",1997,"[Retinoic acid-induced cell growth inhibition and differentiation in testicular carcinoma cells in culture].","9436034","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha_antag","retinoic acid receptor alpha","antag","10684250",2000,"Regulation of skeletal progenitor differentiation by the BMP and retinoid signaling pathways.","10684250","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha_antag","retinoic acid receptor alpha","antag","11212271",2001,"Granulocytic differentiation of human NB4 promyelocytic leukemia cells induced by all-trans retinoic acid metabolites.","11212271","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha_antag","retinoic acid receptor alpha","antag","11778229",2000,"[Mechanism of retinoic acid receptor alpha-mediated growth inhibition of gastric cancer cells by all-trans retinoic acid].","11778229","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha_antag","retinoic acid receptor alpha","antag","11994980",2002,"all-trans-Retinoic acid-induced expression and regulation of retinoic acid 4-hydroxylase (CYP26) in human promyelocytic leukemia.","11994980","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha_antag","retinoic acid receptor alpha","antag","12935977",2003,"All-trans retinoic acid modulates microvascular endothelial cell hemostatic properties.","12935977","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha_antag","retinoic acid receptor alpha","antag","14613895",2004,"Retinoic acid inhibits rat XY gonad development by blocking mesonephric cell migration and decreasing the number of gonocytes.","14613895","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha_antag","retinoic acid receptor alpha","antag","16287870",2005,"Impaired retinoic acid (RA) signal leads to RARbeta2 epigenetic silencing and RA resistance.","16287870","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha_antag","retinoic acid receptor alpha","antag","16872382",2006,"Effect of all-trans-retinoic acid on the differentiation, maturation and functions of dendritic cells derived from cord blood monocytes.","16872382","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha_antag","retinoic acid receptor alpha","antag","18466769",2008,"Acyclic retinoid inhibits functional interaction of transcription factors Krüppel-like factor 5 and retinoic acid receptor-alpha.","18466769","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha_antag","retinoic acid receptor alpha","antag","18641199",2008,"Retinoic acid decreases adherence of murine myeloid dendritic cells and increases production of matrix metalloproteinase-9.","18641199","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha_antag","retinoic acid receptor alpha","antag","19279407",2009,"Mechanisms underlying the induction of the putative human tumor suppressor GPRC5A by retinoic acid.","19279407","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha_antag","retinoic acid receptor alpha","antag","19375825",2009,"Effect of conjugates of all-trans-retinoic acid and shorter polyene chain analogues with amino acids on prostate cancer cell growth.","19375825","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha_antag","retinoic acid receptor alpha","antag","19477911",2009,"All-trans retinoic acid down-regulates inflammatory responses by shifting the Treg/Th17 profile in human ulcerative and murine colitis.","19477911","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha_antag","retinoic acid receptor alpha","antag","21684744",2011,"A transcription factor hijacking to regulate RARα by using a chimeric molecule of retinoic acid and a DNA alkylator.","21684744","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha_antag","retinoic acid receptor alpha","antag","22982681",2012,"CAC1 negatively regulates RARα activity through cooperation with HDAC.","22982681","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha_antag","retinoic acid receptor alpha","antag","23102850",2013,"Retinoic acid signaling biomarkers after treatment with retinoic acid and retinoic acid receptor alpha antagonist (Ro 41-5253) in canine testis: an in vitro organ culture study.","23102850","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha_antag","retinoic acid receptor alpha","antag","23321499",2013,"Zyxin cooperates with PTOV1 to confer retinoic acid resistance by repressing RAR activity.","23321499","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha_antag","retinoic acid receptor alpha","antag","24495389",2014,"Effect of all-trans-retinoic acid on enterovirus 71 infection in vitro.","24495389","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha_antag","retinoic acid receptor alpha","antag","24608861",2014,"E2F1 impairs all-trans retinoic acid-induced osteogenic differentiation of osteosarcoma via promoting ubiquitination-mediated degradation of RARα.","24608861","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha_antag","retinoic acid receptor alpha","antag","24994461",2014,"Retinoic acid acts as a selective human IgA switch factor.","24994461","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha_antag","retinoic acid receptor alpha","antag","25800721",2015,"RARγ is a negative regulator of osteoclastogenesis.","25800721","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha_antag","retinoic acid receptor alpha","antag","7934625",1994,"The prevention of adipose differentiation of 3T3-L1 cells caused by retinoic acid is elicited through retinoic acid receptor alpha.","7934625","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha_antag","retinoic acid receptor alpha","antag","8695801",1996,"Stimulation of tissue-type plasminogen activator expression by retinoic acid in human endothelial cells requires retinoic acid receptor beta 2 induction.","8695801","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha_antag","retinoic acid receptor alpha","antag","8752277",1996,"Two distinct actions of retinoid-receptor ligands.","8752277","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha_antag","retinoic acid receptor alpha","antag","8788040",1996,"Receptor-selective retinoids implicate retinoic acid receptor alpha and gamma in the regulation of bmp-2 and bmp-4 in F9 embryonal carcinoma cells.","8788040","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha_antag","retinoic acid receptor alpha","antag","9153223",1997,"All-trans-retinoic acid increases transforming growth factor-beta2 and insulin-like growth factor binding protein-3 expression through a retinoic acid receptor-alpha-dependent signaling pathway.","9153223","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha_antag","retinoic acid receptor alpha","antag","9160665",1997,"Involvement of retinoic acid receptor-alpha-mediated signaling pathway in induction of CD38 cell-surface antigen.","9160665","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha_antag","retinoic acid receptor alpha","antag","9247151",1997,"9,13-di-cis-Retinoic acid induces the production of tPA and activation of latent TGF-beta via RAR alpha in a human liver stellate cell line, LI90.","9247151","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha_antag","retinoic acid receptor alpha","antag","9342185",1997,"Retinoid-mediated inhibition of cell growth with stimulation of apoptosis in aggressive B-cell lymphomas.","9342185","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor alpha_antag","retinoic acid receptor alpha","antag","9516856",1997,"Retinoids in neuroblastoma therapy: distinct biological properties of 9-cis- and all-trans-retinoic acid.","9516856","Tretinoin","retinoic acid receptor alpha"]
["Tretinoin","retinoic acid receptor beta_ag","retinoic acid receptor beta","ag","15161940",2004,"Non-genomic regulation of transmitter release by retinoic acid at developing motoneurons in Xenopus cell culture.","15161940","Tretinoin","retinoic acid receptor beta"]
["Tretinoin","retinoic acid receptor beta_ag","retinoic acid receptor beta","ag","16038797",2005,"Phosphorylation of the retinoid x receptor at the omega loop, modulates the expression of retinoic-acid-target genes with a promoter context specificity.","16038797","Tretinoin","retinoic acid receptor beta"]
["Tretinoin","retinoic acid receptor beta_ag","retinoic acid receptor beta","ag","19450544",2009,"The ATRA-dependent overexpression of the glutamate transporter EAAC1 requires RARbeta induction.","19450544","Tretinoin","retinoic acid receptor beta"]
["Tretinoin","retinoic acid receptor beta_ag","retinoic acid receptor beta","ag","8752277",1996,"Two distinct actions of retinoid-receptor ligands.","8752277","Tretinoin","retinoic acid receptor beta"]
["Tretinoin","retinoic acid receptor beta_antag","retinoic acid receptor beta","antag","10725232",2000,"Retinoid signaling is essential for patterning the endoderm of the third and fourth pharyngeal arches.","10725232","Tretinoin","retinoic acid receptor beta"]
["Tretinoin","retinoic acid receptor beta_antag","retinoic acid receptor beta","antag","11032179",2000,"Stage-dependent responses of the developing lung to retinoic acid signaling.","11032179","Tretinoin","retinoic acid receptor beta"]
["Tretinoin","retinoic acid receptor beta_antag","retinoic acid receptor beta","antag","11778229",2000,"[Mechanism of retinoic acid receptor alpha-mediated growth inhibition of gastric cancer cells by all-trans retinoic acid].","11778229","Tretinoin","retinoic acid receptor beta"]
["Tretinoin","retinoic acid receptor beta_antag","retinoic acid receptor beta","antag","16287870",2005,"Impaired retinoic acid (RA) signal leads to RARbeta2 epigenetic silencing and RA resistance.","16287870","Tretinoin","retinoic acid receptor beta"]
["Tretinoin","retinoic acid receptor beta_antag","retinoic acid receptor beta","antag","22418437",2012,"Naturally occurring eccentric cleavage products of provitamin A β-carotene function as antagonists of retinoic acid receptors.","22418437","Tretinoin","retinoic acid receptor beta"]
["Tretinoin","retinoic acid receptor beta_antag","retinoic acid receptor beta","antag","24720764",2014,"Retinoic acid reduces migration of human breast cancer cells: role of retinoic acid receptor beta.","24720764","Tretinoin","retinoic acid receptor beta"]
["Tretinoin","retinoic acid receptor beta_antag","retinoic acid receptor beta","antag","8662962",1996,"Inhibition of retinoic acid receptor function and retinoic acid-regulated gene expression in mouse melanoma cells by calreticulin. A potential pathway for cyclic AMP regulation of retinoid action.","8662962","Tretinoin","retinoic acid receptor beta"]
["Tretinoin","retinoic acid receptor beta_antag","retinoic acid receptor beta","antag","8695801",1996,"Stimulation of tissue-type plasminogen activator expression by retinoic acid in human endothelial cells requires retinoic acid receptor beta 2 induction.","8695801","Tretinoin","retinoic acid receptor beta"]
["Tretinoin","retinoic acid receptor beta_antag","retinoic acid receptor beta","antag","8752277",1996,"Two distinct actions of retinoid-receptor ligands.","8752277","Tretinoin","retinoic acid receptor beta"]
["Tretinoin","retinoic acid receptor beta_antag","retinoic acid receptor beta","antag","9160665",1997,"Involvement of retinoic acid receptor-alpha-mediated signaling pathway in induction of CD38 cell-surface antigen.","9160665","Tretinoin","retinoic acid receptor beta"]
["Tretinoin","retinoic acid receptor beta_antag","retinoic acid receptor beta","antag","9343411",1997,"Retinoid-induced chromatin structure alterations in the retinoic acid receptor beta2 promoter.","9343411","Tretinoin","retinoic acid receptor beta"]
["Tretinoin","retinoic acid receptor beta_antag","retinoic acid receptor beta","antag","9516856",1997,"Retinoids in neuroblastoma therapy: distinct biological properties of 9-cis- and all-trans-retinoic acid.","9516856","Tretinoin","retinoic acid receptor beta"]
["Tretinoin","retinoic acid receptor gamma_ag","retinoic acid receptor gamma","ag","15161940",2004,"Non-genomic regulation of transmitter release by retinoic acid at developing motoneurons in Xenopus cell culture.","15161940","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma_ag","retinoic acid receptor gamma","ag","16038797",2005,"Phosphorylation of the retinoid x receptor at the omega loop, modulates the expression of retinoic-acid-target genes with a promoter context specificity.","16038797","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma_ag","retinoic acid receptor gamma","ag","18703560",2008,"Retinoic acid receptor gamma-induced misregulation of chondrogenesis in the murine limb bud in vitro.","18703560","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma_ag","retinoic acid receptor gamma","ag","25800721",2015,"RARγ is a negative regulator of osteoclastogenesis.","25800721","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma_ag","retinoic acid receptor gamma","ag","8788040",1996,"Receptor-selective retinoids implicate retinoic acid receptor alpha and gamma in the regulation of bmp-2 and bmp-4 in F9 embryonal carcinoma cells.","8788040","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma_ag","retinoic acid receptor gamma","ag","9351827",1997,"Phosphorylation of activation functions AF-1 and AF-2 of RAR alpha and RAR gamma is indispensable for differentiation of F9 cells upon retinoic acid and cAMP treatment.","9351827","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma_antag","retinoic acid receptor gamma","antag","11032179",2000,"Stage-dependent responses of the developing lung to retinoic acid signaling.","11032179","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma_antag","retinoic acid receptor gamma","antag","11778229",2000,"[Mechanism of retinoic acid receptor alpha-mediated growth inhibition of gastric cancer cells by all-trans retinoic acid].","11778229","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma_antag","retinoic acid receptor gamma","antag","19279407",2009,"Mechanisms underlying the induction of the putative human tumor suppressor GPRC5A by retinoic acid.","19279407","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma_antag","retinoic acid receptor gamma","antag","25800721",2015,"RARγ is a negative regulator of osteoclastogenesis.","25800721","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma_antag","retinoic acid receptor gamma","antag","8788040",1996,"Receptor-selective retinoids implicate retinoic acid receptor alpha and gamma in the regulation of bmp-2 and bmp-4 in F9 embryonal carcinoma cells.","8788040","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin","retinoic acid receptor gamma_antag","retinoic acid receptor gamma","antag","9160665",1997,"Involvement of retinoic acid receptor-alpha-mediated signaling pathway in induction of CD38 cell-surface antigen.","9160665","Tretinoin","retinoic acid receptor gamma"]
["Tretinoin",{"$f":"C1731&\"_\"&D1731","v":"retinoic acid receptor, beta2, human_antag"},"retinoic acid receptor, beta2, human","antag","22659417",2012,"Epstein-Barr Virus latent membrane protein 1 overcomes all-trans retinoic acid-induced apoptosis by inhibiting retinoic acid receptor-β₂ expression.","22659417","Tretinoin","retinoic acid receptor, beta2, human"]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  I1732,I1732)","v":"Tretinoin"},"Retinoid X Receptor alpha_ag",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  J1732,J1732)","v":"Retinoid X Receptor alpha"},"ag",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & H1732,H1732)","v":"16038797"},2005,"Phosphorylation of the retinoid x receptor at the omega loop, modulates the expression of retinoic-acid-target genes with a promoter context specificity.","16038797","Tretinoin","Retinoid X Receptor alpha"]
["Tretinoin","Retinoid X Receptor alpha_ag","Retinoid X Receptor alpha","ag","18840407",2008,"9-cis retinoic acid induces retinoid X receptor localized to the mitochondria for mediation of mitochondrial transcription.","18840407","Tretinoin","Retinoid X Receptor alpha"]
["Tretinoin","Retinoid X Receptor alpha_ag","Retinoid X Receptor alpha","ag","20945395",2011,"Retinoic acid receptor-mediated signaling protects cardiomyocytes from hyperglycemia induced apoptosis: role of the renin-angiotensin system.","20945395","Tretinoin","Retinoid X Receptor alpha"]
["Tretinoin","Retinoid X Receptor alpha_antag","Retinoid X Receptor alpha","antag","16428452",2006,"TGIF inhibits retinoid signaling.","16428452","Tretinoin","Retinoid X Receptor alpha"]
["Tretinoin","Retinoid X Receptor alpha_antag","Retinoid X Receptor alpha","antag","18786169",2008,"Up-regulation of the SOX3 gene expression by retinoic acid: characterization of the novel promoter-response element and the retinoid receptors involved.","18786169","Tretinoin","Retinoid X Receptor alpha"]
["Tretinoin","Retinoid X Receptor alpha_antag","Retinoid X Receptor alpha","antag","23485459",2013,"Molecular mechanism of 9-cis-retinoic acid inhibition of adipogenesis in 3T3-L1 cells.","23485459","Tretinoin","Retinoid X Receptor alpha"]
["Tretinoin","Retinoid X Receptor alpha_antag","Retinoid X Receptor alpha","antag","26310807",2015,"9-cis-retinoic acid improves sensitivity to platelet-derived growth factor-BB via RXRα and SHP-1 in diabetic retinopathy.","26310807","Tretinoin","Retinoid X Receptor alpha"]
["Tretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","10585260",1999,"The expression and activity of D-type cyclins in F9 embryonal carcinoma cells: modulation of growth by RXR-selective retinoids.","10585260","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","10699977",2000,"Retinoic acid regulates the morphological development of sympathetic neurons.","10699977","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","11022230",2000,"Mechanisms of all-trans retinoic acid-induced differentiation of acute promyelocytic leukemia cells.","11022230","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","11201846",2000,"Thyroid hormone regulation of apoptosis induced by retinoic acid in promyeloleukemic HL-60 cells: studies with retinoic acid receptor-specific and retinoid x receptor-specific ligands.","11201846","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","11223164",2001,"Agonists of the retinoic acid- and retinoid X-receptors inhibit hepatocyte growth factor secretion and expression in U87 human astrocytoma cells.","11223164","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","11319133",2001,"Retinoid receptors involved in the effects of retinoic acid on rat testis development.","11319133","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","11397803",2001,"Regulation of stearoyl coenzyme A desaturase expression in human retinal pigment epithelial cells by retinoic acid.","11397803","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","11500296",2001,"Destabilization of TNF-alpha mRNA by retinoic acid in hepatic macrophages: implications for alcoholic liver disease.","11500296","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","11707111",2001,"Engineering orthogonal ligand-receptor pairs from \"near drugs\".","11707111","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","12006550",2002,"Nuclear receptor agonists as potential differentiation therapy agents for human osteosarcoma.","12006550","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","12169446",2002,"Enhancement of the inducible NO synthase activation by retinoic acid is mimicked by RARalpha agonist in vivo.","12169446","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","12882839",2003,"Retinoic acids exert direct effects on T cells to suppress Th1 development and enhance Th2 development via retinoic acid receptors.","12882839","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","12904083",2003,"Conformationally defined retinoic acid analogues. 5. Large-scale synthesis and mammary cancer chemopreventive activity for (2E,4E,6Z,8E)-8-(3',4'-dihydro-1'(2'H)-naphthalen-1'-ylidene)-3,7-dimethyl-2,4,6-octatrienoic acid (9cUAB30).","12904083","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","14668795",2003,"Retinoic acid receptor alpha and retinoid-X receptor-specific agonists synergistically target telomerase expression and induce tumor cell death.","14668795","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","14975592",2004,"Ligands for the peroxisome proliferator-activated receptor-gamma and the retinoid X receptor exert additive anti-inflammatory effects on experimental autoimmune encephalomyelitis.","14975592","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","15161940",2004,"Non-genomic regulation of transmitter release by retinoic acid at developing motoneurons in Xenopus cell culture.","15161940","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","15546741",2004,"9-cis-retinoic acid analogues with bulky hydrophobic rings: new RXR-selective agonists.","15546741","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","15949693",2005,"Effects of retinoic acid administration and dietary vitamin A supplementation on leptin expression in mice: lack of correlation with changes of adipose tissue mass and food intake.","15949693","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","16011254",2005,"[Advances in studies on selective RXR ligands].","16011254","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","16302920",2005,"Retinoic acid is a potential negative regulator for differentiation of human periodontal ligament cells.","16302920","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","16751185",2006,"Genetic and pharmacological evidence that a retinoic acid cannot be the RXR-activating ligand in mouse epidermis keratinocytes.","16751185","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","17869331",2007,"Retinoid receptor-specific agonists regulate bovine in vitro early embryonic development, differentiation and expression of genes related to cell cycle arrest and apoptosis.","17869331","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","18594976",2009,"Additive inhibitory effect of experimentally induced hepatic cirrhosis by agonists of peroxisome proliferator activator receptor gamma and retinoic acid receptor.","18594976","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","18755147",2008,"RXR agonists inhibit oxidative stress-induced apoptosis in H9c2 rat ventricular cells.","18755147","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","19007552",2008,"Development and quality of bovine morulae cultured in serum-free medium with specific retinoid receptor agonists.","19007552","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","19017957",2008,"Retinoic acids are potent inhibitors of spontaneous human eosinophil apoptosis.","19017957","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","19288012",2009,"Enhanced effects of PPARgamma ligands and RXR selective retinoids in combination to inhibit migration and invasiveness in cancer cells.","19288012","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","19409899",2009,"Placental steroidogenesis in rats is independent of signaling pathways induced by retinoic acids.","19409899","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","19644018",2009,"Combined low doses of PPARgamma and RXR ligands trigger an intrinsic apoptotic pathway in human breast cancer cells.","19644018","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","19678713",2009,"Alitretinoin: in severe chronic hand eczema.","19678713","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","19686701",2010,"Retinoids activate RXR/CAR-mediated pathway and induce CYP3A.","19686701","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","20417372",2010,"[Alitretinoin: Toctino].","20417372","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","20562004",2010,"All-trans retinoic acid enhances the transport of phase II metabolites of benzo[a]pyrene by inducing the Breast Cancer Resistance Protein expression in Caco-2 cells.","20562004","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","21489804",2011,"Replacement of the hydrophobic part of 9-cis-retinoic acid with cyclic terpenoid moiety results in RXR-selective agonistic activity.","21489804","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","22261616",2012,"Nuclear receptors agonists exert opposing effects on the inflammation dependent survival of breast cancer stem cells.","22261616","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","22353356",2012,"Retinoic acid receptor agonists regulate expression of ATP-binding cassette transporter G1 in macrophages.","22353356","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","23441952",2013,"Differential effects of retinoids and inhibitors of ERK and p38 signaling on adipogenic and myogenic differentiation of P19 stem cells.","23441952","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","23605322",2013,"Combinational effect of PPARγ agonist and RXR agonist on the growth of SGC7901 gastric carcinoma cells in vitro.","23605322","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","23992207",2013,"An in vitro model for the pro-fibrotic effects of retinoids: mechanisms of action.","23992207","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","25079278",2014,"Unexpected phenotypes of malformations induced in Xenopus tropicalis embryos by combined exposure to triphenyltin and 9-cis-retinoic acid.","25079278","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","25541638",2015,"RXR agonist modulates TR: corepressor dissociation upon 9-cis retinoic acid treatment.","25541638","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","25752819",2015,"Protein Kinase C Is Involved in the Induction of ATP-Binding Cassette Transporter A1 Expression by Liver X Receptor/Retinoid X Receptor Agonist in Human Macrophages.","25752819","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","7493627",1995,"Identification of a transposon-related RNA down-regulated by retinoic acid in embryonal carcinoma and embryonic stem cells.","7493627","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","7583541",1995,"Retinoids stimulate fibrinogen production both in vitro (hepatocytes) and in vivo. Induction requires activation of the retinoid X receptor.","7583541","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","7608895",1995,"Conformationally defined 6-s-trans-retinoic acid analogs. 2. Selective agonists for nuclear receptor binding and transcriptional activity.","7608895","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","7697779",1994,"Synthesis of 9E- and 9Z-locked retinoic acid analogs as ligands for RAR and RXR.","7697779","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","8752277",1996,"Two distinct actions of retinoid-receptor ligands.","8752277","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","8892963",1996,"9-cis-retinoic acid induces neuronal differentiation of retinoic acid-nonresponsive embryonal carcinoma cells.","8892963","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","9077483",1997,"The retinoid X receptor agonist 9-cis-retinoic acid and the 24-hydroxylase inhibitor ketoconazole increase activity of 1,25-dihydroxyvitamin D3 in human skin in vivo.","9077483","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","9392425",1997,"Mechanism of the slow induction of apolipoprotein A-I synthesis by retinoids in cynomolgus hepatocytes: involvement of retinoic acid and retinoid X receptors.","9392425","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","9816192",1996,"Initial clinical trial of the retinoid receptor pan agonist 9-cis retinoic acid.","9816192","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","9952315",1999,"Greater synergism of retinoic acid receptor (RAR) agonists with vitamin D3 than that of retinoid X receptor (RXR) agonists with regard to growth inhibition and differentiation induction in monoblastic leukemia cells.","9952315","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_antag","Retinoid X Receptors","antag","11278809",2001,"Selective roles of retinoic acid receptor and retinoid x receptor in the suppression of apoptosis by all-trans-retinoic acid.","11278809","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_antag","Retinoid X Receptors","antag","11319133",2001,"Retinoid receptors involved in the effects of retinoic acid on rat testis development.","11319133","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_antag","Retinoid X Receptors","antag","12807734",2003,"Molecular mechanism for growth suppression of human hepatocellular carcinoma cells by acyclic retinoid.","12807734","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_antag","Retinoid X Receptors","antag","12882839",2003,"Retinoic acids exert direct effects on T cells to suppress Th1 development and enhance Th2 development via retinoic acid receptors.","12882839","Tretinoin","Retinoid X Receptors"]
["Tretinoin",{"$f":"C1795&\"_\"&D1795","v":"Retinoid X Receptors_antag"},"Retinoid X Receptors","antag","20648638",2010,"Retinoic acid regulates myelin formation in the peripheral nervous system.","20648638","Tretinoin","Retinoid X Receptors"]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  I1796,I1796)","v":"Tretinoin"},"Retinoid X Receptors_antag",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  J1796,J1796)","v":"Retinoid X Receptors"},"antag",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & H1796,H1796)","v":"21654191"},2011,"Bid as a potential target of apoptotic effects exerted by low doses of PPARγ and RXR ligands in breast cancer cells.","21654191","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_antag","Retinoid X Receptors","antag","23441952",2013,"Differential effects of retinoids and inhibitors of ERK and p38 signaling on adipogenic and myogenic differentiation of P19 stem cells.","23441952","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_antag","Retinoid X Receptors","antag","23992207",2013,"An in vitro model for the pro-fibrotic effects of retinoids: mechanisms of action.","23992207","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_antag","Retinoid X Receptors","antag","24098526",2013,"Amplified inhibition of stellate cell activation pathways by PPAR-γ, RAR and RXR agonists.","24098526","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_antag","Retinoid X Receptors","antag","24371294",2014,"Retinoic acid induces changes in electrical properties of adult neurons in a dose- and isomer-dependent manner.","24371294","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_antag","Retinoid X Receptors","antag","7575611",1995,"Antagonism of COUP-TF and PPAR alpha/RXR alpha on the activation of the malic enzyme gene promoter: modulation by 9-cis RA.","7575611","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_antag","Retinoid X Receptors","antag","8274426",1993,"Mechanism of synergistic action of all-trans- or 9-cis-retinoic acid and interferons in breast cancer cells.","8274426","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_antag","Retinoid X Receptors","antag","8752277",1996,"Two distinct actions of retinoid-receptor ligands.","8752277","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_antag","Retinoid X Receptors","antag","9160665",1997,"Involvement of retinoic acid receptor-alpha-mediated signaling pathway in induction of CD38 cell-surface antigen.","9160665","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_antag","Retinoid X Receptors","antag","9165113",1997,"Retinoid signaling is required for the establishment of a ZPA and for the expression of Hoxb-8, a mediator of ZPA formation.","9165113","Tretinoin","Retinoid X Receptors"]
["Tretinoin","Retinoid X Receptors_antag","Retinoid X Receptors","antag","9952315",1999,"Greater synergism of retinoic acid receptor (RAR) agonists with vitamin D3 than that of retinoid X receptor (RXR) agonists with regard to growth inhibition and differentiation induction in monoblastic leukemia cells.","9952315","Tretinoin","Retinoid X Receptors"]
["Tretinoin","retinol dehydrogenase_antag","retinol dehydrogenase","antag","2660792",1989,"The molecular basis of retinoic acid induced night blindness.","2660792","Tretinoin","retinol dehydrogenase"]
["Tretinoin","Retinol-Binding Proteins_antag","Retinol-Binding Proteins","antag","8610177",1996,"Developmental abnormalities in cultured mouse embryos deprived of retinoic by inhibition of yolk-sac retinol binding protein synthesis.","8610177","Tretinoin","Retinol-Binding Proteins"]
["Tretinoin","thioretinaco_antag","thioretinaco","antag","15244035",2002,"Prevention of homocysteine thiolactone induced atherogenesis in rats.","15244035","Tretinoin","thioretinaco"]
["tributyltin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","9829560",1998,"Interaction of tributyltin with 3,3',4,4',5-pentachlorobiphenyl-induced ethoxyresorufin O-deethylase activity in rat hepatoma cells.","9829560","tributyltin","Cytochrome P-450 CYP1A1"]
["tributyltin","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","21219878",2011,"Tributyltin chloride induces ABCA1 expression and apolipoprotein A-I-mediated cellular cholesterol efflux by activating LXRα/RXR.","21219878","tributyltin","Receptors, Retinoic Acid"]
["tributyltin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","17291456",2007,"Tributyltin and triphenyltin inhibit osteoclast differentiation through a retinoic acid receptor-dependent signaling pathway.","17291456","tributyltin","Receptors, Retinoic Acid"]
["tributyltin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","18670157",2008,"Endocrine disruption induced by organotin compounds; organotins function as a powerful agonist for nuclear receptors rather than an aromatase inhibitor.","18670157","tributyltin","Retinoid X Receptors"]
["tributyltin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","24679120",2014,"Stimulation of estradiol biosynthesis by tributyltin in rat hippocampal slices.","24679120","tributyltin","Retinoid X Receptors"]
["tributyltin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","26090559",2015,"Effects of Tributyltin and Other Retinoid Receptor Agonists in Reproductive-Related Endpoints in the Zebrafish (Danio rerio).","26090559","tributyltin","Retinoid X Receptors"]
["Trichloroethylene","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","736791",1978,"Acetaldehyde level in the blood and liver aldehyde dehydrogenase activities in trichloroethylene-treated rats.","736791","Trichloroethylene","Aldehyde Oxidoreductases"]
["trichostatin A","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","10224119",1999,"Repression of dioxin signal transduction in fibroblasts. Identification Of a putative repressor associated with Arnt.","10224119","trichostatin A","Cytochrome P-450 CYP1A1"]
["Triclosan","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","8696774",1996,"Interaction of 2,4,4'-trichloro-2'-hydroxydiphenyl ether with microsomal cytochrome P450-dependent monooxygenases in rat liver.","8696774","Triclosan","Cytochrome P-450 CYP1A1"]
["trifluoroacetaldehyde hydrate","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","7163339",1982,"Reversible inhibitors of aldehyde dehydrogenase.","7163339","trifluoroacetaldehyde hydrate","Aldehyde Oxidoreductases"]
["Trimeprazine","retinyl esterase_antag","retinyl esterase","antag","16277768",2005,"A comparative study on the effects of oral amiodarone and trimeprazine, two in vitro retinyl ester hydrolase inhibitors, on the metabolic availability of vitamin A in rats.","16277768","Trimeprazine","retinyl esterase"]
["trimethyltin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","18801585",2008,"Acute trimethyltin exposure induces oxidative stress response and neuronal apoptosis in Sebastiscus marmoratus.","18801585","trimethyltin","Cytochrome P-450 CYP1A1"]
["triphenyl phosphate","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","25725299",2015,"Triphenyl phosphate-induced developmental toxicity in zebrafish: potential role of the retinoic acid receptor.","25725299","triphenyl phosphate","Receptors, Retinoic Acid"]
["triphenyltin","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","17291456",2007,"Tributyltin and triphenyltin inhibit osteoclast differentiation through a retinoic acid receptor-dependent signaling pathway.","17291456","triphenyltin","Receptors, Retinoic Acid"]
["triphenyltin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","18670157",2008,"Endocrine disruption induced by organotin compounds; organotins function as a powerful agonist for nuclear receptors rather than an aromatase inhibitor.","18670157","triphenyltin","Retinoid X Receptors"]
["triphenyltin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","23117067",2012,"Interaction of triphenyltin and an agonist of retinoid X receptor (LGD1069) in embryos of Xenopus tropicalis.","23117067","triphenyltin","Retinoid X Receptors"]
["triphenyltin","Retinoid X Receptors_ag","Retinoid X Receptors","ag","25079278",2014,"Unexpected phenotypes of malformations induced in Xenopus tropicalis embryos by combined exposure to triphenyltin and 9-cis-retinoic acid.","25079278","triphenyltin","Retinoid X Receptors"]
["troglitazone","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","10076998",1999,"A novel method for analysis of nuclear receptor function at natural promoters: peroxisome proliferator-activated receptor gamma agonist actions on aP2 gene expression detected using branched DNA messenger RNA quantitation.","10076998","troglitazone","Receptors, Retinoic Acid"]
["troglitazone","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","10936484",2000,"Peroxisome proliferator-activated receptor and retinoid X receptor ligands inhibit monocyte chemotactic protein-1-directed migration of monocytes.","10936484","troglitazone","Receptors, Retinoic Acid"]
["troglitazone","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","11357475",2001,"Peroxisome proliferator-activated receptor (PPAR) gamma and retinoid X receptor (RXR) agonists have complementary effects on glucose and lipid metabolism in human skeletal muscle.","11357475","troglitazone","Receptors, Retinoic Acid"]
["troglitazone","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","11476957",2001,"Combined treatment with specific ligands for PPARgamma:RXR nuclear receptor system markedly inhibits the expression of cytochrome P450arom in human granulosa cancer cells.","11476957","troglitazone","Receptors, Retinoic Acid"]
["troglitazone","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","11708867",2001,"Limited cooperation between peroxisome proliferator-activated receptors and retinoid X receptor agonists in sebocyte growth and development.","11708867","troglitazone","Receptors, Retinoic Acid"]
["troglitazone","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","12006550",2002,"Nuclear receptor agonists as potential differentiation therapy agents for human osteosarcoma.","12006550","troglitazone","Receptors, Retinoic Acid"]
["troglitazone","Retinoblastoma Protein_antag","Retinoblastoma Protein","antag","18355447",2008,"PPARgamma ligands suppress the feedback loop between E2F2 and cyclin-E1.","18355447","troglitazone","Retinoblastoma Protein"]
["troglitazone","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","10936484",2000,"Peroxisome proliferator-activated receptor and retinoid X receptor ligands inhibit monocyte chemotactic protein-1-directed migration of monocytes.","10936484","troglitazone","retinoic acid receptor alpha"]
["troglitazone","Retinoid X Receptors_ag","Retinoid X Receptors","ag","10076998",1999,"A novel method for analysis of nuclear receptor function at natural promoters: peroxisome proliferator-activated receptor gamma agonist actions on aP2 gene expression detected using branched DNA messenger RNA quantitation.","10076998","troglitazone","Retinoid X Receptors"]
["troglitazone","Retinoid X Receptors_ag","Retinoid X Receptors","ag","11357475",2001,"Peroxisome proliferator-activated receptor (PPAR) gamma and retinoid X receptor (RXR) agonists have complementary effects on glucose and lipid metabolism in human skeletal muscle.","11357475","troglitazone","Retinoid X Receptors"]
["troglitazone","Retinoid X Receptors_ag","Retinoid X Receptors","ag","11476957",2001,"Combined treatment with specific ligands for PPARgamma:RXR nuclear receptor system markedly inhibits the expression of cytochrome P450arom in human granulosa cancer cells.","11476957","troglitazone","Retinoid X Receptors"]
["troglitazone","Retinoid X Receptors_ag","Retinoid X Receptors","ag","11708867",2001,"Limited cooperation between peroxisome proliferator-activated receptors and retinoid X receptor agonists in sebocyte growth and development.","11708867","troglitazone","Retinoid X Receptors"]
["troglitazone","Retinoid X Receptors_ag","Retinoid X Receptors","ag","12006550",2002,"Nuclear receptor agonists as potential differentiation therapy agents for human osteosarcoma.","12006550","troglitazone","Retinoid X Receptors"]
["troglitazone","Retinoid X Receptors_ag","Retinoid X Receptors","ag","16525649",2006,"Effects of PPAR and RXR ligands in semaphorin 6B gene expression of human MCF-7 breast cancer cells.","16525649","troglitazone","Retinoid X Receptors"]
["troglitazone","Retinoid X Receptors_ag","Retinoid X Receptors","ag","23605322",2013,"Combinational effect of PPARγ agonist and RXR agonist on the growth of SGC7901 gastric carcinoma cells in vitro.","23605322","troglitazone","Retinoid X Receptors"]
["Troleandomycin","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","2395109",1990,"Inhibition of rat liver estrogen 2/4-hydroxylase activity by troleandomycin: comparison with erythromycin and roxithromycin.","2395109","Troleandomycin","Cytochrome P-450 CYP1A1"]
["tryolobibenzyl D","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","12240985",2002,"Structure of tyrolobibenzyl D and biological activity of tyrolobibenzyls from Scorzonera humilis.","12240985","tryolobibenzyl D","Cytochrome P-450 CYP1A1"]
["UAB 30","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","12904083",2003,"Conformationally defined retinoic acid analogues. 5. Large-scale synthesis and mammary cancer chemopreventive activity for (2E,4E,6Z,8E)-8-(3',4'-dihydro-1'(2'H)-naphthalen-1'-ylidene)-3,7-dimethyl-2,4,6-octatrienoic acid (9cUAB30).","12904083","UAB 30","Receptors, Retinoic Acid"]
["UAB 30","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","19197145",2009,"Prevention of KLF4-mediated tumor initiation and malignant transformation by UAB30 rexinoid.","19197145","UAB 30","Receptors, Retinoic Acid"]
["UAB 30","retinoic acid receptor gamma_ag","retinoic acid receptor gamma","ag","19197145",2009,"Prevention of KLF4-mediated tumor initiation and malignant transformation by UAB30 rexinoid.","19197145","UAB 30","retinoic acid receptor gamma"]
["UAB 30","Retinoid X Receptor alpha_ag","Retinoid X Receptor alpha","ag","19197145",2009,"Prevention of KLF4-mediated tumor initiation and malignant transformation by UAB30 rexinoid.","19197145","UAB 30","Retinoid X Receptor alpha"]
["UAB 30","Retinoid X Receptor alpha_ag","Retinoid X Receptor alpha","ag","24801499",2014,"Methyl substitution of a rexinoid agonist improves potency and reveals site of lipid toxicity.","24801499","UAB 30","Retinoid X Receptor alpha"]
["UAB 30","Retinoid X Receptors_ag","Retinoid X Receptors","ag","12904083",2003,"Conformationally defined retinoic acid analogues. 5. Large-scale synthesis and mammary cancer chemopreventive activity for (2E,4E,6Z,8E)-8-(3',4'-dihydro-1'(2'H)-naphthalen-1'-ylidene)-3,7-dimethyl-2,4,6-octatrienoic acid (9cUAB30).","12904083","UAB 30","Retinoid X Receptors"]
["UAB 30","Retinoid X Receptors_ag","Retinoid X Receptors","ag","20335511",2010,"Murine oncogenicity and pharmacokinetics studies of 9-cis-UAB30, an RXR agonist, for breast cancer chemoprevention.","20335511","UAB 30","Retinoid X Receptors"]
["UAB 30","Retinoid X Receptors_ag","Retinoid X Receptors","ag","23292798",2013,"Effects on gene expression in rat liver after administration of RXR agonists: UAB30, 4-methyl-UAB30, and Targretin (Bexarotene).","23292798","UAB 30","Retinoid X Receptors"]
["Ubiquinone","retinoid isomerohydrolase_antag","retinoid isomerohydrolase","antag","22843363",2012,"Coenzyme Q10 protects retinal cells from apoptosis induced by radiation in vitro and in vivo.","22843363","Ubiquinone","retinoid isomerohydrolase"]
["Uracil","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","8161345",1994,"5-ethynyl-2(1H)-pyrimidinone: aldehyde oxidase-activation to 5-ethynyluracil, a mechanism-based inactivator of dihydropyrimidine dehydrogenase.","8161345","Uracil","Aldehyde Oxidoreductases"]
["Urea","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","12547725",2003,"Retinal dehydrogenase-2 is inhibited by compounds that induce congenital diaphragmatic hernias in rodents.","12547725","Urea","Aldehyde Oxidoreductases"]
["Urea","Retinal Dehydrogenase_antag","Retinal Dehydrogenase","antag","12547725",2003,"Retinal dehydrogenase-2 is inhibited by compounds that induce congenital diaphragmatic hernias in rodents.","12547725","Urea","Retinal Dehydrogenase"]
["UVI 3003","Retinoid X Receptors_antag","Retinoid X Receptors","antag","24950139",2014,"Effects of antagonist of retinoid X receptor (UVI3003) on morphology and gene profile of Xenopus tropicalis embryos.","24950139","UVI 3003","Retinoid X Receptors"]
["UVI 3003","Retinoid X Receptors_antag","Retinoid X Receptors","antag","25186191",2015,"A representative retinoid X receptor antagonist UVI3003 induced teratogenesis in zebrafish embryos.","25186191","UVI 3003","Retinoid X Receptors"]
["Valproic Acid","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","376783",1979,"Di-n-propylacetate and GABA degradation. Preferential inhibition of succinic semialdehyde dehydrogenase and indirect inhibition of GABA-transaminase.","376783","Valproic Acid","Aldehyde Oxidoreductases"]
["Valproic Acid",{"$f":"C1859&\"_\"&D1859","v":"Aldehyde Oxidoreductases_antag"},"Aldehyde Oxidoreductases","antag","6094147",1984,"[Mechanisms of action and biochemical toxicology of valproic acid].","6094147","Valproic Acid","Aldehyde Oxidoreductases"]
[{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  I1860,I1860)","v":"Valproic Acid"},"Aldehyde Oxidoreductases_antag",{"$f":"HYPERLINK(\"https://meshb.nlm.nih.gov/#/fieldSearch?searchInField=allTerms&searchType=exactMatch&q=\" &  J1860,J1860)","v":"Aldehyde Oxidoreductases"},"antag",{"$f":"HYPERLINK(\"http://www.ncbi.nlm.nih.gov/pubmed/\" & H1860,H1860)","v":"6275228"},1981,"Central actions of valproic acid in man and in experimental models of epilepsy.","6275228","Valproic Acid","Aldehyde Oxidoreductases"]
["Valproic Acid","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","6405398",1983,"Isosterism and molecular modification in drug design: new n-dipropylacetate analogs as inhibitors of succinic semi aldehyde dehydrogenase.","6405398","Valproic Acid","Aldehyde Oxidoreductases"]
["Valproic Acid","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","6773525",1980,"Effects of benzodiazepines and valproic acid on brain aldehyde reductase and a proposed mechanism of anticonvulsant action.","6773525","Valproic Acid","Aldehyde Oxidoreductases"]
["Valproic Acid","Aldehyde Oxidoreductases_antag","Aldehyde Oxidoreductases","antag","6783097",1981,"Biogenic aldehyde metabolism in rat brain. Differential sensitivity of aldehyde reductase isoenzymes to sodium valproate.","6783097","Valproic Acid","Aldehyde Oxidoreductases"]
["Vitamin A","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","10462515",1999,"Inhibitory effects of vitamin A and vitamin K on rat cytochrome P4501A1-dependent monooxygenase activity.","10462515","Vitamin A","Cytochrome P-450 CYP1A1"]
["Vitamin A","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","15728703",2005,"Inhibitory effects of vitamin A on TCDD-induced cytochrome P-450 1A1 enzyme activity and expression.","15728703","Vitamin A","Cytochrome P-450 CYP1A1"]
["Vitamin A","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","10663782",2000,"[Inhibition of proliferation of retinal pigment epithelium in vitro: vitamin A pharmacodynamics I].","10663782","Vitamin A","Receptors, Retinoic Acid"]
["Vitamin A","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","11970994",2002,"Vitamin A enhances in vitro Th2 development via retinoid X receptor pathway.","11970994","Vitamin A","Receptors, Retinoic Acid"]
["Vitamin A","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","15949693",2005,"Effects of retinoic acid administration and dietary vitamin A supplementation on leptin expression in mice: lack of correlation with changes of adipose tissue mass and food intake.","15949693","Vitamin A","Receptors, Retinoic Acid"]
["Vitamin A","Receptors, Retinoic Acid_ag","Receptors, Retinoic Acid","ag","18511283",2008,"Synthesis and in vitro biological activity of retinyl retinoate, a novel hybrid retinoid derivative.","18511283","Vitamin A","Receptors, Retinoic Acid"]
["Vitamin A","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","10867750",2000,"Is autism a G-alpha protein defect reversible with natural vitamin A?","10867750","Vitamin A","Receptors, Retinoic Acid"]
["Vitamin A","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","20534877",2010,"Vitamin A upregulates matrix metalloproteinase-9 activity by murine myeloid dendritic cells through a nonclassical transcriptional mechanism.","20534877","Vitamin A","Receptors, Retinoic Acid"]
["Vitamin A","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","24340023",2013,"Vitamin a is a negative regulator of osteoblast mineralization.","24340023","Vitamin A","Receptors, Retinoic Acid"]
["Vitamin A","retinoic acid 4-hydroxylase_antag","retinoic acid 4-hydroxylase","antag","24340023",2013,"Vitamin a is a negative regulator of osteoblast mineralization.","24340023","Vitamin A","retinoic acid 4-hydroxylase"]
["Vitamin A","retinoic acid 4-hydroxylase_antag","retinoic acid 4-hydroxylase","antag","8757760",1996,"Liarozole inhibits human epidermal retinoic acid 4-hydroxylase activity and differentially augments human skin responses to retinoic acid and retinol in vivo.","8757760","Vitamin A","retinoic acid 4-hydroxylase"]
["Vitamin A","retinoic acid binding protein II, cellular_ag","retinoic acid binding protein II, cellular","ag","18511283",2008,"Synthesis and in vitro biological activity of retinyl retinoate, a novel hybrid retinoid derivative.","18511283","Vitamin A","retinoic acid binding protein II, cellular"]
["Vitamin A","retinoic acid receptor alpha_ag","retinoic acid receptor alpha","ag","15949693",2005,"Effects of retinoic acid administration and dietary vitamin A supplementation on leptin expression in mice: lack of correlation with changes of adipose tissue mass and food intake.","15949693","Vitamin A","retinoic acid receptor alpha"]
["Vitamin A","retinoic acid receptor alpha_antag","retinoic acid receptor alpha","antag","20534877",2010,"Vitamin A upregulates matrix metalloproteinase-9 activity by murine myeloid dendritic cells through a nonclassical transcriptional mechanism.","20534877","Vitamin A","retinoic acid receptor alpha"]
["Vitamin A","Retinoid X Receptors_ag","Retinoid X Receptors","ag","11970994",2002,"Vitamin A enhances in vitro Th2 development via retinoid X receptor pathway.","11970994","Vitamin A","Retinoid X Receptors"]
["Vitamin A","Retinoid X Receptors_ag","Retinoid X Receptors","ag","15949693",2005,"Effects of retinoic acid administration and dietary vitamin A supplementation on leptin expression in mice: lack of correlation with changes of adipose tissue mass and food intake.","15949693","Vitamin A","Retinoid X Receptors"]
["Vitamin A","retinol dehydratase_antag","retinol dehydratase","antag","15608121",2005,"The structures of the unique sulfotransferase retinol dehydratase with product and inhibitors provide insight into enzyme mechanism and inhibition.","15608121","Vitamin A","retinol dehydratase"]
["Vitamin B 12","N-homocysteine thiolactonyl retinamide_antag","N-homocysteine thiolactonyl retinamide","antag","15244035",2002,"Prevention of homocysteine thiolactone induced atherogenesis in rats.","15244035","Vitamin B 12","N-homocysteine thiolactonyl retinamide"]
["Vitamin B 12","thioretinaco_antag","thioretinaco","antag","15244035",2002,"Prevention of homocysteine thiolactone induced atherogenesis in rats.","15244035","Vitamin B 12","thioretinaco"]
["Vitamin E","retinol-palmitate esterase_antag","retinol-palmitate esterase","antag","6712231",1984,"Vitamin A metabolism: alpha-tocopherol modulates tissue retinol levels in vivo, and retinyl palmitate hydrolysis in vitro.","6712231","Vitamin E","retinol-palmitate esterase"]
["Vitamin E","retinyl esterase_antag","retinyl esterase","antag","6497842",1984,"Alpha-tocopherol and phylloquinone as non-competitive inhibitors of retinyl ester hydrolysis.","6497842","Vitamin E","retinyl esterase"]
["Vitamin K","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","10462515",1999,"Inhibitory effects of vitamin A and vitamin K on rat cytochrome P4501A1-dependent monooxygenase activity.","10462515","Vitamin K","Cytochrome P-450 CYP1A1"]
["Vitamin K 1","retinyl esterase_antag","retinyl esterase","antag","6497842",1984,"Alpha-tocopherol and phylloquinone as non-competitive inhibitors of retinyl ester hydrolysis.","6497842","Vitamin K 1","retinyl esterase"]
["WEB 2086","Receptors, Retinoic Acid_antag","Receptors, Retinoic Acid","antag","15674364",2005,"WEB-2086 and WEB-2170 trigger apoptosis in both ATRA-sensitive and -resistant promyelocytic leukemia cells and greatly enhance ATRA differentiation potential.","15674364","WEB 2086","Receptors, Retinoic Acid"]
["xanthohumol","Cytochrome P-450 CYP1A1_antag","Cytochrome P-450 CYP1A1","antag","10752639",2000,"In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops, Humulus lupulus.","10752639","xanthohumol","Cytochrome P-450 CYP1A1"]